Links
Useful Databases
InterPro protein domain and family database
IntAct interaction database at the EBI
PDB Protein Data Bank
HIC-Up Hetero-compound Information Centre - Uppsala University
CCDC Cambridge Crystallographic Data Centre
PDBbind Binding affinity data for protein-ligand complexes in the PDB
BindingDB Binding affinities, mainly for interactions of potential drug-targets with small, drug-like molecules.
PubChem at the NCBI.
Tools
FingerPRINTScan from PRINTS
Motif3D for visualising motifs on 3D structures.
Phosphatase Reviews
Protein tyrosine phosphatases: functional inferences from mouse models and human diseases.
Hendriks WJ, Elson A, Harroch S, Stoker AW.
FEBS J. 2008 Mar;275(5):816-30.
Abstract
Protein tyrosine phosphatases: regulatory mechanisms.
den Hertog J, Ostman A, Böhmer FD.
FEBS J. 2008 Mar;275(5):831-47.
Abstract
Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease.
Pulido R, van Huijsduijnen RH.
FEBS J. 2008 Mar;275(5):848-66.
Abstract
Protein tyrosine phosphatases: structure-function relationships.
Tabernero L, Aricescu AR, Jones EY, Szedlacsek SE.
FEBS J. 2008 Mar;275(5):867-82.
Abstract
A brief introduction to the protein phosphatase families.
Mustelin T.
Methods Mol Biol. 2007;365:9-22.
Abstract
Role of mitogen-activated protein kinase phosphatases (MKPs) in cancer.
Wu GS.
Cancer Metastasis Rev. 2007 Dec;26(3-4):579-85.
Abstract
The TriTryp phosphatome: analysis of the protein phosphatase catalytic domains.
Brenchley R, Tariq H, McElhinney H, Szoor B, Huxley-Jones J, Stevens R, Matthews K, Tabernero L.
BMC Genomics. 2007 Nov 26;8:434.
Abstract
Protein tyrosine phosphatase PTPN22 in human autoimmunity.
Vang T, Miletic AV, Bottini N, Mustelin T.
Autoimmunity. 2007 Sep;40(6):453-61.
Abstract
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases.
Owens DM, Keyse SM.
Oncogene. 2007 May 14;26(22):3203-13.
Abstract
Proteomic approaches to studying protein tyrosine phosphatases.
Liang F, Kumar S, Zhang ZY.
Mol Biosyst. 2007 May;3(5):308-16. Epub 2007 Mar 21.
Abstract
Role of receptor and nonreceptor protein tyrosine kinases in H2O2-induced PKB and ERK1/2 signaling.
Mehdi MZ, Azar ZM, Srivastava AK.
Cell Biochem Biophys. 2007;47(1):1-10.
Abstract
MAPK phosphatases--regulating the immune response.
Liu Y, Shepherd EG, Nelin LD.
Nat Rev Immunol. 2007 Mar;7(3):202-12.
Abstract
Structure-based drug design of new leads for phosphatase research.
Combs AP.
IDrugs. 2007 Feb;10(2):112-5.
Abstract
Protein tyrosine phosphatases and cancer
Ostman A, Hellberg C, Böhmer FD.
Nat. Rev. Cancer, 2006. 6(4):307-320
Abstract
Protein Tyrosine Phosphatases in the Human Genome
Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T
Cell, 2004. 117:699-711
Abstract
A genomic perspective on protein tyrosine phosphatases: gene structure,pseudogenes, and genetic disease linkage
Andersen JN, Jansen PG, Echwald SM, Mortensen OH, Fukada T, Del Vecchio R, Tonks NK, Moller NPH
FASEB J., 2004. 18:8-30
Abstract
Recent Relevant Publications
Molecular analysis of receptor protein tyrosine phosphatase mu mediated cell adhesion
Aricescu AR, Hon WC, Siebold C, Lu W, van der Merwe PA, Jones EY.
EMBO J., 2006. 25(4):701-712
Abstract