AMYB_SOYBN.di:

10617198| Many genes encode predicted proteins that are homologous to human and Caenorhabditis elegans proteins.
9677422| This suggests that the binding site of the cyclodextrins is important for its holding of a cleaved substrate, which enablesthe multiple attack mechanism of beta-amylase.
9461215| Other interesting features were found, such as the sequence of a disease-resistance gene locus, the distribution ofretroelements, the frequent occurrence of clustered gene families, and the sequence of several classes of genes not previouslyencountered in plants.

ANXB_HUMAN.di:

7508441| Anti-56K autoantibodies are present in sera from patients with various autoimmune diseases, predominantly in sera frompatients with rheumatoid arthritis, systemic lupus erythematosus, or Sjogren's syndrome. 
7508441| Patients' sera recognize preferentially the N-terminal region of the protein, which is specific for 56K/annexin XI and notshared by other annexins, indicating that the autoimmune response to 56K/annexin XI in these patients is specific for thisannexin family member.
7508441| The in vitro translated protein is recognized by all anti-56K positive patient sera tested.
12477932| The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify andsequence a cDNA clone containing a complete ORF for each human and mouse gene.
8938449| Knowledge of the mouse cDNA sequence and genetic map location will assist in the analysis of genomic organization andexpression and provide a useful animal model to investigate gene function and hereditary phenotype for annexin XI.

BRS3_HUMAN.di:

8131855| This subtype of bombesin receptor is expressed in the pregnant uterus and in two human tumour cell lines, T47D (ductalbreast carcinoma) and A431 (epidermal carcinoma).
8383682| The bombesin (BN)-like peptides mediate a diverse spectrum of biological activities and have been implicated as autocrinegrowth factors in the pathogenesis and progression of some human small cell lung carcinoma tumors.
8383682| These results suggest a role for BN-like peptides and their receptors in mammalian reproductive physiology and also indicatethat BRS-3 could serve as a potential therapeutic target for human lung carcinoma.
8383682| BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. (title)
8383682| In contrast, BRS-3 mRNA is widely expressed in a panel of human cell lines from all histological types of lung carcinoma.
9573346| Nothing is known about mechanisms regulating BRS-3 gene expression and possible association with disease.

CB2R_HUMAN.di:

7689702| Marijuana, and delta 9-THC, also exert a wide range of other effects including analgesia, anti-inflammation,immunosuppression, anticonvulsion, alleviation of intraocular pressure in glaucoma, and attenuation of vomiting.
9261404| In addition, proviral integrations were demonstrated within the 3' untranslated region of Cnr2 in five independent newlyderived CasBrM-MuLV (mouse murine leukemia virus) tumors, CSL13, CSL14, CSL16, CSL27, and CSL97.
7689702| The clinical application of cannabinoids has, however, been limited by their psychoactive effects, and this has led tointerest in the biochemical bases of their action.
12477932| The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify andsequence a cDNA clone containing a complete ORF for each human and mouse gene.
9261404| A new common region of virus integration, Evi11, has been identified in two retrovirally induced murine myeloid leukemiacell lines, NFS107 and NFS78.

DVL3_MOUSE.di:

11354832| Furthermore, DVL-1 is involved in the Notch signalling system, which plays a role in the disorder cerebral autosomaldominant arteriopathy with subcortical infarcts and leukoencephalopathy, the symptoms of, which include ischaemicstroke.
8644734| Deletions of 22q11 have also been reported with patients with the velocardio-facial syndrome and familial conotruncalheart defects. 
8644734| DiGeorge syndrome (DGS) is a developmental defect of some of the neural crest derivatives. 
8644734| Since DGS may be due to perturbation of differentiation mechanisms at decisive embryological stages, a Dsh-like gene in thesmall-region overlap (SRO) might be a candidate for the pathogenesis of this disorder.
8644734| Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome. (title)
8149913| Here, we show that loss of dishevelled function in clones, in double heterozygotes with wingless mutants and in flies bearinga weak dishevelled transgene leads to patterning defects which phenocopy defects observed in wingless mutants alone.
9344861| cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas.(title)
11354832| Mapping and sequencing rat dishevelled-1: a candidate gene for cerebral ischaemic insult in a rat model of stroke.(title)
11354832| A quantitative trait locus on chromosome 5 in the rat is linked to sensitivity to brain ischemia in the stroke-pronespontaneously hypertensive rat (SHRSP).
11354832| Our results essentially exclude the DVL-1 gene as the cause for sensitivity to cerebral ischaemic insult in this ratmodel of stroke.
8644734| Most DGS patients show haploinsufficiency due to interstitial deletions of the proximal long arm of chromosome 22.
8644734| Sequences homologous to the 3' UTR of these transcripts (DVL-22) were positioned within the DGS critical region and werefound to be deleted in DGS patients.
8887313| We have developed an assay for dsh function in fly embryos, and show that Dvl2 can partially rescue the segmentationdefects of embryos devoid of dsh.
8149913| Further, polarized cells in all body segments require dishevelled function to establish planar cell polarity, and somewingless alleles and dishevelled; wingless double heterozygotes exhibit bristle polarity defects identical to those seen indishevelled alone.
9298901| Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1. (title)
9298901| Thus, Dvl1 mutants may provide a model for aspects of several human psychiatric disorders.
9344861| DVL-3 mRNA was detected in normal human breast tissues (n = 4) and tumours (n = 25).
9344861| Statistically, there was no difference in DVL-3 mRNA level between normal breast tissues and tumours.
9344861| In human colorectal samples, DVL-3 was expressed equally in matched normal tissues, polyps and tumours.
7958461| While no functional motifs were identified, one region of Dvl-1 was found to be similar to a domain of discs large-1 (dlg), aDrosophila tumor suppressor gene.
8922524| The region of highest conservation between all three Dvl coding regions, at 97% identity, is noted at the PDZ domain (alsotermed the DHR domain or GLGF motif), a motif of 60 amino acids present in all dishevelled encoded proteins and first describedin the Drosophila discs large (dlg) tumor suppressor gene.
8817329| Although the precise role of these genes in embryogenesis is only conjectural at present, the structural and evolutionarycharacteristics suggest that mutations at their loci may be involved in neural and heart developmental defects.
9192851| Two of these regions do not exhibit significant sequence similarity with other known proteins; the third is similar to thediscs-large homology region, which was first found in a Drosophila Discs-large tumor suppressor protein (also known as GLGF orPDZ domain).
12477932| The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify andsequence a cDNA clone containing a complete ORF for each human and mouse gene.

ELIA_PHYCP.di:

8994969| These proteins induce leaf necrosis in infected plants and elicit an incompatible hypersensitive-like reaction, leading tothe development of a systemic acquired resistance against a range of fungal and bacterial plant pathogens.
2583277| The phytopathogenic fungi Phytophthora cinnamomi cause systemic leaf necrosis on its non-host tobacco; in culture, itsecretes a protein, called cinnamomin, which elicits leaf necrosis and protects tobacco against the pathogen Phytophthoranicotianoe, in a way similar to cryptogein and different from capsicein, elicitins of known amino acid sequences.
2776750| In addition, both proteins protect tobacco against invasion by the pathogen Phytophthora nicotianac, the agent of thetobacco black shank, that is unable to produce such an elicitor.
2776750| Secondary structure predictions, hydropathy and flexibility profiles differ only around position 15 and at the C-terminus;these modifications could play a role in the modulation of their biological activities.
9385630| Elicitins are necrotic and signaling proteins secreted by Phytophthora spp. responsible for the incompatible reaction andsystemic hypersensitive-like necroses of diverse plant species leading to resistance against fungal or bacterial plantpathogens.
8664508| Involvement of elicitins in plant-pathogen interactions is discussed.
8031752| Capsicein belongs to the elicitin family, elicitor molecules having toxic and signaling properties that are secreted byPhytophthora fungi, responsible for the incompatible hypersensitive reaction of diverse plant species leading to resistanceagainst fungal or bacterial plant pathogens.
8994969| RESULTS: The structure of CRY was determined using the multiwavelength anomalous diffraction technique and refined to 2.2 Aresolution.
8994969| CONCLUSIONS: The determination of the crystal structure of a member of the elicitin family may make it possible to separatethe activity that causes leaf necrosis from that inducing systemic acquired resistance to pathogens, making it feasible toengineer a non-toxic elicitin that only elicits plant defences.

FLGK_ECOLI.di:

11677608| Salmonella enterica serovar Typhi (S. typhi) is the aetiological agent of typhoid fever, a serious invasive bacterialdisease of humans with an annual global burden of approximately 16 million cases, leading to 600,000 fatalities. 
11677609| Salmonella enterica subspecies I, serovar Typhimurium (S. typhimurium), is a leading cause of human gastroenteritis, andis used as a mouse model of human typhoid fever.
11677609| The 352 gene homologues of S. typhimurium LT2 confined to subspecies I of S. enterica-containing most mammalian and birdpathogens-are useful for studies of epidemiology, host specificity and pathogenesis.
12644504| We present the 4.8-Mb complete genome sequence of Salmonella enterica serovar Typhi strain Ty2, a human-specific pathogencausing typhoid fever.
11677608| CT18 harbours a 218,150-bp multiple-drug-resistance incH1 plasmid (pHCM1), and a 106,516-bp cryptic plasmid (pHCM2),which shows recent common ancestry with a virulence plasmid of Yersinia pestis.
11677609| The incidence of non-typhoid salmonellosis is increasing worldwide, causing millions of infections and many deaths in thehuman population each year.
11677609| Here we sequenced the 4,857-kilobase (kb) chromosome and 94-kb virulence plasmid of S. typhimurium strain LT2.
11677609| Most of these homologues were previously unknown, and 50 may be exported to the periplasm or outer membrane, rendering themaccessible as therapeutic or vaccine targets.
8158647| Two mutants with defects in hook-associated protein 3 (HAP3) were isolated that exhibit impaired swimming only when theyinteract with a solid surface or a semisolid matrix.
12644504| While CT18 carries two plasmids, one conferring multiple drug resistance, Ty2 has no plasmids and is sensitive toantibiotics.
2193164| Together, these observations suggest that the axial proteins may have amphipathic alpha-helical structure at their N and Ctermini.
11677608| Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18. (title)
11677608| Here we have sequenced the 4,809,037-base pair (bp) genome of a S. typhi (CT18) that is resistant to multiple drugs,revealing the presence of hundreds of insertions and deletions compared with the Escherichia coli genome, ranging in size fromsingle genes to large islands.
11677608| Notably, the genome sequence identifies over two hundred pseudogenes, several corresponding to genes that are known tocontribute to virulence in Salmonella typhimurium.

GAA6_CHICK.di:

8388764| The locus order was further confirmed by DNA hybridization analysis of two patients, one with Angelman syndrome and onewith Prader-Willi syndrome, with different unbalanced translocations and molecular extents of deletion. 
11992121| Although many genes that predispose for epilepsy in humans have been determined, those that underlie the classicalsyndromes of idiopathic generalized epilepsy (IGE) have yet to be identified.
11326274| Generalized epilepsy with febrile seizures plus (GEFS+), benign familial neonatal convulsions and nocturnal frontal lobeepilepsy, three autosomal dominant idiopathic epilepsies, result from mutations affecting voltage-gated sodium andpotassium channels, and nicotinic acetylcholine receptors, respectively.
10602120| Rett syndrome (RTT) is an X-linked dominant neurodevelopmental disorder that affects females. 
8388764| FISH ordering of reference markers and of the gene for the alpha 5 subunit of the gamma-aminobutyric acid receptor (GABRA5)within the Angelman and Prader-Willi syndrome chromosomal regions. (title) 
11992121| Our results confirm that mutation of GABRA1 predisposes towards a common idiopathic generalized epilepsy syndrome inhumans.
11326274| 8), an autosomal dominant disorder associating febrile seizures and generalized epilepsy previously linked tomutations in sodium channel genes.
10602120| Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq. (title) 
10602120| The genomic characterization of GLUR3 and GABRA3 will allow mutational analysis of these genes as candidates for otherX-linked neurological disorders mapping to Xq25-Xq26 and Xq28. 
9527017| Gamma-aminobutyric acid (GABA)A receptors are the sites of action for many antiepileptic drugs such as benzodiazepinesand barbiturates. 
11992121| Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy. (title)
11326274| First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene. (title)
11326274| Major advances in the identification of genes implicated in idiopathic epilepsy have been made.
11326274| We thus provide the first genetic evidence that a GABA(A) receptor is directly involved in human idiopathic epilepsy.
2165521| By their allosteric, drug-induced modulation, they serve as control elements for the regulation of anxiety, vigilance,and epileptiform activity.
11992121| We report that an Ala322Asp mutation in GABRA1, encoding the alpha1 subunit of the gamma-aminobutyric acid receptor subtypeA (GABA(A)), is found in affected individuals of a large French Canadian family with juvenile myoclonic epilepsy.
10602120| No disease-causing mutations were found, but several single-nucleotide polymorphisms (SNPs) were detected.
10602120| These SNPs will be useful in future linkage analysis and whole-genome association studies for other diseases.
9339354| The GABRE gene extends over 14 kb and is clustered together with the alpha 3 and the putative beta 4 GABAA receptor subunitgenes in an approximately 0.8-Mb interval in chromosome band Xq28, located in the candidate regions of two different neurologicdiseases.
1660002| The gamma 3-subunit could functionally replace the gamma 2-subunit with regard to the bi-directional allosteric drugmodulation.
2842688| Neurotransmitter action at the GABAA receptor is potentiated by both benzodiazepines and barbiturates which aretherapeutically useful drugs (reviewed in ref.
7607683| Moreover, if duplication of the alpha gene occurred before duplication of the ancestral gene cluster, then a heretoforeundiscovered subtype of alpha subunit should be located on human chromosome 15q11-q13 within an alpha 5-alpha x-beta 3-gamma 3gene cluster at the locus for Angelman and Prader-Willi syndromes.
9039914| At concentrations relevant to clinical anaesthesia, these agents cause a dramatic stimulation of the chloride currents thatare evoked by the binding of the natural ligand, GABA.
8388764| Our results provide a framework map of chromosome 15q11-q13 into which additional markers can be oriented and allow a furtherdifferentiation of the critical genetic regions of the two syndromes.
2167378| This action is potentiated by both benzodiazepine and barbiturate drugs.
11003197| We previously identified a QTL on mouse Chromosome 11 that affects genetic predisposition to acute alcohol withdrawal.
11003197| RESULTS: Allelic variation in Gabrg2 is correlated genetically with predisposition to acute alcohol withdrawal and mayunderlie the Alcw3 locus.
11326274| Disruption of GABAergic neurotransmission mediated by gamma-aminobutyric acid (GABA) has been implicated in epilepsy formany decades.
12477932| The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify andsequence a cDNA clone containing a complete ORF for each human and mouse gene.
11326275| Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. (title)
11326275| We have found a mutation in a gene encoding a GABA(A) receptor subunit in a large family with epilepsy.
11326275| The two main phenotypes were childhood absence epilepsy (CAE) and febrile seizures (FS).
11326275| There is a recognized genetic relationship between FS and CAE, yet the two syndromes have different ages of onset, andthe physiology of absences and convulsions is distinct.
11326275| This suggests the mutation has age-dependent effects on different neuronal networks that influence the expression of theseclinically distinct, but genetically related, epilepsy phenotypes.
2170110| When co-expressed with alpha and beta subunits in Xenopus oocytes and mammalian cells, the gamma variants mediate thepotentiation of GABA evoked currents by benzodiazepines and help generate high-affinity binding sites for these drugs.

HH1R_BOVIN.di:
MID 12142541:  Hrh1-/- mice are protected from VAASH, which can be restored by genetic complementation with a susceptible Bphs/Hrh1allele, and experimental allergic encephalomyelitis and autoimmune orchitis due to immune deviation.
12142541| Identification of Bphs, an autoimmune disease locus, as histamine receptor H1. (title)
1722337| This investigation discloses the molecular nature of the H1 receptor--a receptor that mediates diverse neuronal andperipheral actions of histamine and that may be of therapeutic importance in allergy.
8917588| In brains of homozygous mutant mice, no specific binding of (3H)pyrilamine was seen. (3H)Doxepin has two saturable bindingsites with higher and lower affinities in brains of wild-type mice, but H1R-deficient mice showed only the weak labeling of(3H)doxepin that corresponds to lower-affinity binding sites.
12142541| Thus, natural alleles of Hrh1 control both the autoimmune T cell and vascular responses regulated by histamine after PTXsensitization.
8280179| Binding studies with (3H)pyrilamine on membranes from transfected cells revealed saturable specific binding with a KD of1.2 nM and a Bmax of 3400 fmol/mg protein.
8280179| In transfected COS-7 cells, histamine induced inositol phosphate formation, that was inhibitable by pyrilamine.

HUGA_VESVU.di:

8828537| Yellow jacket venom allergens, hyaluronidase and phospholipase: sequence similarity and antigenic cross-reactivity with theirhornet and wasp homologs and possible implications for clinical allergy. (title)
8828537| The low degree of cross-reactivity of the immunodominant discontinuous B-cell epitopes of vespid allergens should be takeninto consideration in selection of venoms for immunotherapy of patients with sensitivity to multiple vespids. 
10998264| N-Glycan analysis by matrix-assisted laser desorption/ionization mass spectrometry of electrophoretically separatednonmammalian proteins: application to peanut allergen Ara h 1 and olive pollen allergen Ole e 1. (title)
7876212| Sequence identity and antigenic cross-reactivity of white face hornet venom allergen, also a hyaluronidase, with otherproteins. (title)
7876212| Dol m 2 has 56% sequence identity with the honey bee venom allergen hyaluronidase and 27% identity with PH-20, a humansperm protein with hyaluronidase activity.
7876212| These findings are relevant to some patients' multiple sensitivity to hornet and bee stings.

KBF2_HUMAN.di:

8036016| Rearrangement of the NFKB-2 gene was also detected in DNA from two patients with CTCL. 
1531086| Transient-transfection experiments in embryonal carcinoma cells demonstrate a functional cooperation between p50B andRelB or p65 in transactivation of a reporter plasmid dependent on a kappa B site.
9384558| BACKGROUND: Members of the rel/NFkappaB family of transcription factors play a vital role in the regulation of rapid cellularresponses, such as those required to fight infection or react to cellular stress.
11239468| Further, a natural mutation of the gene encoding NIK in alymphoplasia (aly) mice cripples the function of NIK in p100processing, causing a severe defect in p52 production.
9950430| Furthermore, kinase-inactive TPL-2 blocks the degradation of p105 induced by tumour-necrosis factor-alpha.
1992489| Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbolester or tumor necrosis factor alpha. (title)
1992489| The DNA binding subunit of nuclear factor kappa B (NF-kappa B), a B-cell protein that interacts with the immunoglobulin kappalight-chain gene enhancer, has been purified from nuclei of human HL-60 cells stimulated with tumor necrosis factor alpha (TNFalpha), and internal peptide sequences were obtained.
8036016| Rearrangement and altered expression of the NFKB-2 gene in human cutaneous T-lymphoma cells. (title)
8036016| We have identified a rearrangement of the NFKB-2 gene in the HUT 78 human cutaneous T-cell leukemia (CTCL) line, cDNA andgenomic DNA sequence predicted the presence of a truncated 80 kD NFKB-2 precursor protein (p80HT), instead of the normal p100protein.
7969113| NF-kappa B is an inducible transcription factor complex which regulates the expression of a variety of genes which areinvolved in the immune, inflammatory, and acute-phase responses.
7969113| The genomic structure and sequence of NF-kappa B2 revealed the presence of two promoters and at least four kappa B regulatoryelements, which mediate responsiveness to phorbol myristate acetate and tumor necrosis factor alpha.
8087845| These inhibitors also block the activation of NF-kappa B and the rapid degradation of I kappa B alpha induced by tumornecrosis factor alpha.
12477932| The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify andsequence a cDNA clone containing a complete ORF for each human and mouse gene.
11297557| Tumor necrosis factor alpha (TNFalpha) and interleukin-1alpha (IL-1alpha) stimulate p105 degradation, releasingassociated Rel subunits to translocate into the nucleus.
11297557| By using knockout embryonic fibroblasts, it was first established that the IkappaB kinase (IKK) complex is essential forthese pro-inflammatory cytokines to trigger efficiently p105 degradation.

OTX2_BRARE.di:

7720578| Various treatments of early embryos cause a general reorganization of Xotx2 expression.
7720578| In particular, retinoic acid treatment essentially abolishes Xotx2 expression in neuroectoderm.
12477932| The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify andsequence a cDNA clone containing a complete ORF for each human and mouse gene.

PENK_XENLA.di:

1721992| The expression of the fusion gene constructs were detected and could be induced 10- to 30-fold upon treatment withforskolin.(ABSTRACT TRUNCATED AT 250 WORDS)
12477932| The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify andsequence a cDNA clone containing a complete ORF for each human and mouse gene.

PRO2_HUMAN.di:

7601111| Profilin II binds actin with a similar affinity to that of profilin I, although it inhibits actin polymerization morestrongly than profilin I under non-equilibrium conditions.
12477932| The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify andsequence a cDNA clone containing a complete ORF for each human and mouse gene.

RBS_TOBAC.di:

8425051| The three genes, designated rbcS1, -2 and -3A are similarly expressed in cotyledons of dark-grown seedlings, in immaturetomato fruit, and in leaves under conditions of water stress.

SEP7_HUMAN.di:

11511094| Interestingly, this brain-specific Bradeion gene is also expressed in two human cancers, colorectal cancer andmalignant melanoma. 
12747765| In the current study, ninety-four distinct antigens reactive with serum IgG from breast cancer patients were identifiedby immunoscreening breast cancer-derived cDNA expression libraries (SEREX). 
12747765| This study adds to the growing list of breast cancer antigens defined by SEREX and to the ultimate objective ofidentifying the complete repertoire of immunogenic gene products in human cancer (the cancer immunome). 
12747765| MAGE-3, MAGE-6, NY-ESO-1, Her2neu and p53, as well as newly-defined breast cancer antigens, e.g. kinesin 2, TATAelement modulatory factor 1, tumor protein D52 and MAGE D, and novel gene products, e.g. 
12747765| In addition, mRNA encoding tumor protein D52 was overexpressed in 60% of breast cancer specimens, while transcriptsencoding SNT-1 signal adaptor protein were downregulated in 70% of these cases. 
11511094| Ectopic expression of normal Bradeion alpha and beta transcripts were confirmed both in patients' tumor samples and inin vitro cultured human cancer cell lines.
12747765| Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (title) 
12747765| With regard to expression profiles, two of the novel gene products, NY-BR-62 and NY-BR-85, were characterized by a highlevel of testicular mRNA expression, and were overexpressed in 60% and 90% of breast cancers, respectively. 
9889007| Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene.(title) 
9889007| We assigned two human expressed sequence tags (ESTs), WI-15444 and SGC32067, homologous to mouse brain protein h5, to thecritical region for Meckel syndrome (MKS) on 17q22-q23. 
9385360| A human gene similar to Drosophila melanogaster peanut maps to the DiGeorge syndrome region of 22q11. (title) 
9385360| The mouse homologue, Pnutl1, maps to MMU16 adding to the growing number of genes from the DiGeorge syndrome region thatmap to this chromosome. 
11322766| Interestingly, MSF the closest paralog of septin 3 is a fusion partner in a therapy-related acute myeloid leukemia.
11859360| Fifty genes have significant similarity with human disease genes; half of these are cancer related.
12747765| The ability of the immune system to recognize structurally altered, amplified or aberrantly expressed proteins can be usedto identify molecules of etiologic relevance to cancer and to define targets for cancer immunotherapy.
12747765| A serological profile was generated for each antigen on the basis of reactivity with allogeneic sera from normalindividuals and cancer patients, and mRNA expression profiles for coding sequences were assembled based upon the tissuedistribution of expressed sequence tags, Northern blots and real-time RT-PCR.
12747765| Forty antigens reacted exclusively with sera from cancer patients.
10731132| The genome encodes approximately 13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but withcomparable functional diversity.
9520435| Data analysis using cDNA/genomic DNA alignments and bio-informatic algorithms revealed 12 different predicted proteins, mostof which are absent from bacterial databases, half of which are absent from Saccharomyces cerevisiae, and nearly all of whichhave relatives in Caenorhabditis elegans and Homo sapiens.
9520435| We conclude that industrially scaled robogenomics in model organisms will have great impact if it can be realistically linkedto epigenetic analyses of human variation and to phenotypic analyses of human diseases in different genetic backgrounds.
8152419| Morphogenesis in Candida albicans, a major fungal pathogen of humans, consists of both budding and the formation of hyphae.
8152419| The latter is thought to be related to the pathogenesis and invasiveness of C. albicans.
8152419| Both C. albicans genes are capable of complementing defects in the respective S. cerevisiae genes.
11322766| An expression sequence tag identified in a screen for genes upregulated by retinoic acid induced neuronal differentiationof the human teratocarcinoma cell line Ntera2/D1 was found in close genomic proximity to a region of high sequence homology tothe septin subfamily of GTPase genes.
11322766| We present the genomic localization and organization on chromosome 22q13.2, a chromosomal hot spot for translocationsimplicated in leukemia.
12747765| These included well-characterized tumor antigens, e.g.
9889007| For the sequence analyses in MKS patients, we isolated the corresponding human gene, PNUTL2, by analyzing an Image cDNAclone that contained these ESTs.
9889007| Mutation analysis using sequencing of RT-PCR products and Northern blot analysis in MKS patients exclude PNUTL2 as the genefor MKS.
12477932| The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify andsequence a cDNA clone containing a complete ORF for each human and mouse gene.
9385360| The gene, which we call PNUTL1, maps to the region of 22q11.2 frequently deleted in DiGeorge and velo-cardio-facialsyndromes and is particularly highly expressed in the brain.
11511094| Expression changes in subsets of genes occur in the course of altering cell fates, i.e., aging, cell death, andcarcinogenesis.
11511094| These changes simultaneously provide the good candidate as a biomarker for monitoring cancer.
11511094| Thus the Bradeion provides valuable tools as a tumor-specific and selective marker.

STRP_STREQ.di:

11296296| Consistent with the observation that S. pyogenes is responsible for a wider variety of human disease than any otherbacterial species, more than 40 putative virulence-associated genes have been identified.
11296296| Additional genes have been identified that encode proteins likely associated with microbial "molecular mimicry"of host characteristics and involved in rheumatic fever or acute glomerulonephritis.
11296296| The 1,852,442-bp sequence of an M1 strain of Streptococcus pyogenes, a Gram-positive pathogen, has been determined andcontains 1,752 predicted protein-encoding genes.
11296296| These prophage-associated genes encode at least six potential virulence factors, emphasizing the importance ofbacteriophages in horizontal gene transfer and a possible mechanism for generating new strains with increased pathogenicpotential.

TGR3_RAT.di:

9245986| To identify mutations that cause hereditary hemorrhagic telangiectasia (HHT, or Rendu-Osler-Weber syndrome),clinical evaluations and genetic studies were performed on 32 families. 
10625079| Hereditary hemorrhagic telangiectasia (HHT) is a dominantly inherited vascular disorder that is heterogeneous interms of age of onset and clinical manifestations.
7894484| Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by multisystemic vasculardysplasia and recurrent haemorrhage.
9157574| Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by multisystem vasculardysplasia and recurrent hemorrhage.
9554745| Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant disorder characterized by multisystemic vasculardysplasia and recurrent hemorrhage from the sites of vascular lesions.
10545596| ENDOGLIN codes for a homodimeric membrane glycoprotein that interacts with receptors for members of the TGF-betasuperfamily and is the gene mutated in the autosomal dominant vascular disorder hereditary hemorrhagic telangiectasia type1 (HHT1).
9157574| We examined the endoglin gene in a Japanese patient with HHT and her family members. 
10625079| We report the analysis of umbilical vein endothelial cells in 28 newborns from 24 families with a clinical diagnosis ofHHT.
8294451| Antibodies, raised against a peptide corresponding to the intracellular domain of porcine endoglin, immunoprecipitated an84-kDa protein under reducing condition and a 130-kDa protein under nonreducing condition in porcine aortic endothelialcells.
9245986| Furthermore, because the clinical manifestation of disease in these eight families was similar, we hypothesize thatphenotypic variation of HHT is not related to a particular ENG mutation.
8194490| After chemical cross-linking with (125I)TGF beta 1 and immunoprecipitation with the polyclonal antihuman endoglin serum, aradiolabeled band of mol wt 180,000 corresponding to dimeric endoglin was observed under nonreducing conditions, whereas asingle band of mol wt 90,000 was seen under reducing conditions.
9554745| The type and location of most of the previously described mutations in the endoglin (ENG) gene suggested a dominant-negativemodel of receptor-complex dysfunction for the molecular basis of this disorder.
9554745| These combined data suggest that the nature of most ENG mutations is to create a null (nonfunctional) allele, and that thereis no requirement for the synthesis of a truncated endoglin protein in the pathogenesis of HHT.
10545596| Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism forhereditary hemorrhagic telangiectasia type 1. (title)
10545596| We recently demonstrated that functional endoglin was expressed at half levels on human umbilical vein endothelial cells(HUVECs) and peripheral blood activated monocytes from HHT1 patients.
10545596| Two types of mutant protein were previously analyzed, the product of an exon 3 skip which was expressed as a transientintracellular species and prematurely truncated proteins that were undetectable in patient samples.
10545596| Metabolic labeling of activated monocytes from confirmed, clinically affected patients revealed reduced expression offully processed normal endoglin in all cases.
10625079| Identification of hereditary hemorrhagic telangiectasia type 1 in newborns by protein expression and mutation analysis ofendoglin. (title)
10625079| Our data confirm that endoglin levels correlate with the presence or absence of mutation in HHT1 families, allowing theearly identification of affected newborns that should be screened clinically to avoid serious complications of this disorder,such as cerebral arteriovenous malformations.
7894484| Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1.(title)
7894484| In the present study, endoglin, a transforming growth factor beta (TGF-beta) binding protein, was analysed as a candidategene for the disorder based on chromosomal location, expression pattern and function.
7894484| We have identified endoglin as the HHT gene mapping to 9q3 and have established HHT as the first human disease defined by amutation in a member of the TGF-beta receptor complex.
9245986| Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia. (title)
9157574| A novel missense mutation in the endoglin gene in hereditary hemorrhagic telangiectasia. (title)
9554745| Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles. (title)

VFUS_VACCC.di:

2389560| In this investigation we show that acid pH treatment of wild-type vaccinia virus-infected cells triggers strong fusionof cells in culture, with an optimum at pH 4.8. 
2033392| The occurrence of the TAAAT sequence upstream from the initiation codon indicates that the sequence is likely to betranscribed late in infection.
1856205| Antiserum to the purified recombinant protein, expressed in bacteria, reacted specifically with a Mr 35,000 polypeptide thatwas detected starting 2 h after virus infection and that co-sedimented with RNA polymerase purified from virions.
8384129| Analysis of variola virus nucleotide sequence revealed proteins belonging to several families which provide the virus withthe possibility of overcoming the barriers of specific and non-specific host defence against viral infection.
2822962| The 14-kilodalton protein appears to play an important role in virus penetration at the level of cell fusion; it also elicitsneutralizing antibodies, and it forms covalently linked trimers on the surface of virions and in infected cells (Rodriguez etal., J.

VGLG_IHNV.di:

3005478| Treatment of nude mice with anti-asialo-GM1 allowed BHK cells persistently infected with wild-type VSV to form tumours,and BHK cells persistently infected with VSV-P were resistant to natural killer (NK) cells in vitro; this implicates NK cellsin the in vivo rejection of persistently infected tumours and in the selection of the VSV-P variant. 
3005478| BHK-21 cells readily produce tumours in athymic nude mice, but BHK-21 cells persistently infected with wild-typevesicular stomatitis virus (VSV) do not. 
1736537| A human strain isolated on cell culture from the saliva of a patient with clinical rabies had only five amino aciddifferences with the canine isolate, an indication of their close relatedness. 
3005478| However, rare persistently infected virus-shedding tumours (VSV-P tumour cells) were independently derived by in vivoselection on three different occasions.
3005478| Cloned viruses isolated from each of these (VSV-P virus mutants) carried mutations determining the VSV-P phenotype becausethey all allowed growth of virus-shedding tumours in nude mice when they were used to persistently infect normal (unselected)BHK-21 cells.
3005478| In this paper, we have sequenced the glycoprotein (G protein), matrix (M) and non-structural (NS) proteins of threeindependently derived VSV-P type mutants to find mutations associated with in vivo passage of persistently infected nude mousetumours and with resistance to NK cells.
2822842| Sigma virus, the hereditary agent of a CO2-induced paralysis of Drosophila, is classified as a rhabdovirus on a molecularbasis.
2741347| However, unlike its vesicular stomatitis virus (Indiana serotype) counterpart, the Chandipura G protein has no potentialpalmitate-accepting cysteine residue within its cytoplasmic domain.
1413521| The genome of bovine ephemeral fever rhabdovirus contains two related glycoprotein genes. (title)
1413521| A 3789 nucleotide region of the bovine ephemeral fever virus (BEFV) genome, located 1.65 kb downstream of the N gene, hasbeen cloned and sequenced.
1413521| The second ORF encodes a polypeptide of 586 amino acids which also has characteristics of a rhabdovirus glycoprotein,including putative signal and transmembrane domains and eight potential glycosylation sites, and appears to correspond to a90-kDa nonstructural glycoprotein (GNS) identified in BEFV-infected cells (Walker et al. (1991) J.
1413521| Highest homology scores for each protein were with sigma virus and vesicular stomatitis virus serotypes.
3459163| Start and stop transcription signals located at the border of each gene encoding a protein have been identified and aresimilar to the corresponding signals from vesicular stomatitis virus (VSV) and Sendai virus.
6268840| Nucleotide sequences of the mRNA's encoding the vesicular stomatitis virus G and M proteins determined from cDNA clonescontaining the complete coding regions. (title)
6268840| The complete nucleotide sequences of the vesicular stomatitis virus mRNA's encoding the glycoprotein (G) and the matrixprotein (M) have been determined from cDNA clones that contain the complete coding sequences from each mRNA.
6268840| The mRNA encoding the vesicular stomatitis virus M protein is 831 nucleotides long, excluding polyadenylic acid, andencodes a protein of 229 amino acids.
6298453| Nucleotide sequence of a cDNA clone encoding the entire glycoprotein from the New Jersey serotype of vesicular stomatitisvirus. (title)
6298453| The nucleotide sequence of the mRNA encoding the glycoprotein from the New Jersey serotype of vesicular stomatitis virus(VSV) was determined from a cDNA clone containing the entire coding region.
3005478| Evolution of vesicular stomatitis virus in athymic nude mice: mutations associated with natural killer cell selection.(title)
3005478| This suggests but does not prove a role for the G protein in NK cell killing of infected cells.
2822842| Rhabdovirus sigma, the hereditary CO2 sensitivity agent of Drosophila: nucleotide sequence of a cDNA clone encoding theglycoprotein. (title)
2822842| We have purified its genome which after 32P-labelling was used as a probe to detect mRNAs in infected cells.
2985803| DNA sequences were determined for three cDNA clones encoding vesicular stomatitis virus glycoproteins from the tsO45 mutant(which encodes a glycoprotein that exhibits temperature-sensitive cell-surface transport), the wild-type parent strain, and aspontaneous revertant of tsO45.
2985803| The DNA sequence analysis showed that as many as three amino acid changes could be responsible for the transport defect.
2985803| Comparison of the predicted glycoprotein sequences from two vesicular stomatitis virus strains suggests a possible basisfor the differential carbohydrate requirement in transport of the two glycoproteins.
3033264| The predicted amino acid sequence was compared with that of the glycoprotein of the Indiana and New Jersey serotypes ofvesicular stomatitis virus and with the glycoprotein of rabies virus, using a computer program which determined optimalalignment.
3033264| An amino acid identity of approximately 20% was found between infectious hematopoietic necrosis virus and the two vesicularstomatitis virus serotypes and between infectious hematopoietic necrosis virus and rabies virus.
1736537| This equilibrium could be rapidly displaced, giving the virus the capacity to adapt easily to new environmental conditions.
2168974| Polymerase errors accumulating during natural evolution of the glycoprotein gene of vesicular stomatitis virus Indianaserotype isolates. (title)
2168974| We report the entire glycoprotein (G) gene nucleotide sequences of 26 vesicular stomatitis virus Indiana serotype (VSV IND)type 1 isolates from North and Central America.
2168974| A high degree of VSV genetic diversity was found in Central America, with several virus subtypes of both VSV IND and NJserotypes existing in this mainly enzootic disease region.