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PR01271

Identifier
HISDACETLASE  [View Relations]  [View Alignment]  
Accession
PR01271
No. of Motifs
7
Creation Date
21-MAR-2000
Title
Histone deacetylase signature
Database References
PRINTS; PR01270 HDASUPER
PDB; 1C3P; 1C3R; 1C3S
SCOP; 1C3P; 1C3R; 1C3S
CATH; 1C3P; 1C3R; 1C3S
Literature References
1. LEIPE, D.D. AND LANDSMAN, D.
Histone deacetylases, acetoin utilisation proteins and acetylpolyamine
amidohydrolases are members of an ancient protein superfamily.
NUCLEIC ACIDS RES. 25 3693-3697 (1997).
 
2. JOHNSON, C.A. AND TURNER, B.M. 
Histone deacetylases: complex transducers of nuclear signals.
SEMIN.CELL DEV.BIOL. 10 179-188 (1999).
 
3. FINNIN, M.S., DONIGIAN J.R., COHEN, A., RICHON, V.M., RIFKIND, R.A.,
MARKS, P.A., BRESLOW, R. AND PAVLETICH, N.P.
Structures of a histone deacetylase homologue bound to the TSA and SAHA
inhibitors.
NATURE 401 188-193 (1999).
 
4. AYER, D.E.
Histone deacetylases: transcriptional repression with SINers and NuRDs.
TRENDS CELL BIOL. 9 193-198 (1999).
 
5. KOUZARIDES, T.
Histone acetylases and deacetylases in cell proliferation.
CURR.OPIN.GENET.DEV. 9 40-48 (1999).
 
6. ARCHER, S.Y. AND HODIN, R.A.
Histone acetylation and cancer.
CURR.OPIN.GENET.DEV. 9 171-174 (1999).

Documentation
Histone deacetylases (HDA), acetoin utilisation proteins (ACUC) and
acetylpolyamine amidohydrolases (APHA) form an ancient protein superfamily
and are all believed to catalyse the deacetylation of a substrate [1]. HDAs
are found in eukaryotes, from yeast to humans; ACUCs are found in 
eubacteria; and APHAs occur in archaeal bacteria, eubacteria and some
eukaryotic organisms [1]. HDA nomenclature is confusing: the family
can also be identified by the codes RPD, HOS, HD and HDAC, regardless of
specific sequence similarities [1]. HDAs may have evolved at least twice
from APHAs, the more recent gene duplication event resembling APHAs more 
closely [1].
 
Only the most highly conserved regions in the group of HDAs including RPD3
are similar to regions in the prokaryotic enzymes [2]. Many of the invariant
residues are histidine, glycine, cysteine, aspartic acid or glutamic acid,
and may be essential for maintaining structural integrity or catalytic
activity [1,2]. Histidines and acidic amino acids may be required for the
co-ordination of metal ion cofactors; APHA is known to contain one zinc ion
that is necessary for catalysis [2].
 
The crystal structure of a HDA homologue from the hyperthermophilic
bacterium Aquifex aeolicus has revealed that it has a single domain
structure belonging to the open alpha/beta class of folds [3]. It consists
of a central eight-stranded parallel beta-sheet and 16 alpha-helices [3].
Seven loops form an active site comprising a tubular pocket, a zinc-binding
site and two Asp-His charge relay systems; thus the active site has features
of metalloproteases and serine proteases [3].
 
HDAs function in multi-subunit complexes, reversing the acetylation of
histones by histone acetyltransferases [4,5], and are also believed to
deacetylate general transcription factors such as TFIIF and sequence-
specific transcription factors such as p53 [4]. Thus, HDAs contribute to 
the regulation of transcription, in particular transcriptional repression
[1-5]. At N-terminal tails of histones, removal of the acetyl group from
the epsilon-amino group of a lysine side chain will restore its positive
charge, which may stabilise the histone-DNA interaction and prevent
activating transcription factors binding to promoter elements [1]. HDAs
play important roles in the cell cycle and differentiation, and their
deregulation can contribute to the development of cancer [5,6].
 
HISDACETLASE is a 7-element fingerprint that provides a signature for
histone deacetylases. The fingerprint was derived from an initial alignment
of 11 sequences: the motifs were drawn from conserved regions spanning 
virtually the full alignment length, focusing on those sections that
characterise the HDAs but distinguish them from the rest of the HDA
superfamily. Three iterations on SPTR37_10f were required to reach 
convergence, at which point a true set comprising 26 sequences was
identified. Two partial matches were also found, both of which are members
of the HDA superfamily that match 2 motifs.
Summary Information
  26 codes involving  7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
2 codes involving 2 elements
Composite Feature Index
726262626262626
60000000
50000000
40000000
30000000
21210000
1234567
True Positives
HD11_XENLA    HD12_XENLA    HDA1_CAEEL    HDA1_CHICK    
HDA1_HUMAN HDA1_MOUSE HDA1_STRPU HDA2_CAEEL
HDA2_CHICK HDA2_HUMAN HDA2_MOUSE HDA3_CHICK
HDA3_HUMAN HDAC_ARATH HDAC_DROME HDAC_MAIZE
HOS2_YEAST O43268 O59702 O62339
O77213 O88895 O96519 PHD1_SCHPO
Q9ZTP8 RPD3_YEAST
True Positive Partials
Codes involving 2 elements
HOS1_YEAST O88896
Sequence Titles
HD11_XENLA  PROBABLE HISTONE DEACETYLASE 1-1 (HD1) (MATERNALLY-EXPRESSED HISTONE DEACETYLASE) (HDM) (AB21) - XENOPUS LAEVIS (AFRICAN CLAWED FROG). 
HD12_XENLA PROBABLE HISTONE DEACETYLASE 1-2 (HD1) (RPD3 HOMOLOG) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
HDA1_CAEEL PROBABLE HISTONE DEACETYLASE 1 - CAENORHABDITIS ELEGANS.
HDA1_CHICK HISTONE DEACETYLASE 1 (HD1) - GALLUS GALLUS (CHICKEN).
HDA1_HUMAN HISTONE DEACETYLASE 1 (HD1) - HOMO SAPIENS (HUMAN).
HDA1_MOUSE HISTONE DEACETYLASE 1 (HD1) - MUS MUSCULUS (MOUSE).
HDA1_STRPU HISTONE DEACETYLASE 1 (HD1) - STRONGYLOCENTROTUS PURPURATUS (PURPLE SEA URCHIN).
HDA2_CAEEL PUTATIVE HISTONE DEACETYLASE C08B11.2 - CAENORHABDITIS ELEGANS.
HDA2_CHICK HISTONE DEACETYLASE 2 (HD2) - GALLUS GALLUS (CHICKEN).
HDA2_HUMAN HISTONE DEACETYLASE 2 (HD2) - HOMO SAPIENS (HUMAN).
HDA2_MOUSE HISTONE DEACETYLASE 2 (HD2) (YY1 TRANSCRIPTION FACTOR BINDING PROTEIN) - MUS MUSCULUS (MOUSE).
HDA3_CHICK HISTONE DEACETYLASE 3 (HD3) - GALLUS GALLUS (CHICKEN).
HDA3_HUMAN HISTONE DEACETYLASE 3 (HD3) - HOMO SAPIENS (HUMAN).
HDAC_ARATH HISTONE DEACETYLASE (HD) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
HDAC_DROME PROBABLE HISTONE DEACETYLASE (HD) (DRPD3) - DROSOPHILA MELANOGASTER (FRUIT FLY).
HDAC_MAIZE PROBABLE HISTONE DEACETYLASE (RPD3 HOMOLOG) - ZEA MAYS (MAIZE).
HOS2_YEAST PROBABLE HISTONE DEACETYLASE HOS2 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
O43268 RPD3-2A - HOMO SAPIENS (HUMAN).
O59702 HISTONE DEACETYLASE - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O62339 R06C1.1 PROTEIN - CAENORHABDITIS ELEGANS.
O77213 PUTATIVE HISTONE DEACETYLASE - DROSOPHILA MELANOGASTER (FRUIT FLY).
O88895 HISTONE DEACETYLASE 3 - MUS MUSCULUS (MOUSE).
O96519 HISTONE DEACETYLASE DHDAC3 - DROSOPHILA MELANOGASTER (FRUIT FLY).
PHD1_SCHPO PROBABLE HISTONE DEACETYLASE PHD1 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
Q9ZTP8 HISTONE DEACETYLASE - ZEA MAYS (MAIZE).
RPD3_YEAST HISTONE DEACETYLASE RPD3 (TRANSCRIPTIONAL REGULATORY PROTEIN RPD3) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).

HOS1_YEAST HOS1 PROTEIN - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
O88896 HISTONE DEACETYLASE 3 - MUS MUSCULUS (MOUSE).
Scan History
SPTR37_10f 3  40   NSINGLE    
Initial Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
MKPHRIRMTHNLLLNYGL HDA1_CHICK 30 30 -
MKPHRIRMTHNLLLNYGL HDA1_HUMAN 30 30 -
MKPHRIRMTHNLLLNYGL HDA2_CHICK 31 31 -
MKPHRIRMTHNLLLNYGL HDA2_MOUSE 31 31 -
MKPHRIRMTHNLILNYGL HDA1_STRPU 29 29 -
MKPHRIRMTHNLLLNYGL HDA2_HUMAN 31 31 -
MKPHRIRMTHHLVLNYGL HDA1_CAEEL 34 34 -
MKPHRIRMTHALLAHYGL HDAC_ARATH 38 38 -
MKPHRLALTHSLVLHYGL HDA3_CHICK 24 24 -
MKPHRLALTHSLVLHYGL HDA3_HUMAN 24 24 -
MKPQRLVVCNDLVVSYEM HDA2_CAEEL 50 50 -

Motif 2 width=19
Element Seqn Id St Int Rpt
EMTKYHSDDYIKFLRSIRP HDA1_CHICK 63 15 -
EMTKYHSDDYIKFLRSIRP HDA1_HUMAN 63 15 -
EMTKYHSDEYIKFLRSIRP HDA2_CHICK 64 15 -
EMTKYHSDEYIKFLRSIRP HDA2_MOUSE 64 15 -
EMTKYHSDDYVKFLRTIRP HDA1_STRPU 62 15 -
EMTKYHSDEYIKFLRSIRP HDA2_HUMAN 64 15 -
DMTRFHSDEYMTFLKSANP HDA1_CAEEL 67 15 -
DLCRFHADDYVSFLRSITP HDAC_ARATH 71 15 -
DMCRFHSEDYIDFLQRVSP HDA3_CHICK 57 15 -
DMCRFHSEDYIDFLQRVSP HDA3_HUMAN 57 15 -
DISVFHTEDYVNFLQTVTP HDA2_CAEEL 83 15 -

Motif 3 width=18
Element Seqn Id St Int Rpt
FNVGEDCPVFDGLFEFCQ HDA1_CHICK 94 12 -
FNVGEDCPVFDGLFEFCQ HDA1_HUMAN 94 12 -
FNVGEDCPVFDGLFEFCQ HDA2_CHICK 95 12 -
FNVGEDCPVFDGLFEFCQ HDA2_MOUSE 95 12 -
FNVGEDCPVFDGLYEFCQ HDA1_STRPU 93 12 -
FNVGEDCPAFDGLFEFCQ HDA2_HUMAN 95 12 -
FNVGEDCPLFDGLYEFCQ HDA1_CAEEL 98 12 -
FNVGEDCPVFDGLYSFCQ HDAC_ARATH 102 12 -
FNVGDDCPVFPGLFEFCS HDA3_CHICK 88 12 -
FNVGDDCPVFPGLFEFCS HDA3_HUMAN 88 12 -
FNIGEDCPIFAGLWDYCT HDA2_CAEEL 115 13 -

Motif 4 width=21
Element Seqn Id St Int Rpt
GGSVASAVKLNKQQTDIAVNW HDA1_CHICK 115 3 -
GGSVASAVKLNKQQTDIAVNW HDA1_HUMAN 115 3 -
GGSVAGAVKLNRQQTDMAVNW HDA2_CHICK 116 3 -
GGSVAGAVKLNRQQTDMAVNW HDA2_MOUSE 116 3 -
GGSVAGAVKLNKQQTDIAINW HDA1_STRPU 114 3 -
GGSVAGAVKLNRQQTDMAVNW HDA2_HUMAN 116 3 -
GGSLAAATKLNKQKVDIAINW HDA1_CAEEL 119 3 -
GGSVGGSVKLNHGLCDIAINW HDAC_ARATH 123 3 -
GASLQGATQLNNKICDIAINW HDA3_CHICK 109 3 -
GASLQGATQLNNKICDIAINW HDA3_HUMAN 109 3 -
GGSVEGARRLNHKMNDIVINW HDA2_CAEEL 136 3 -

Motif 5 width=17
Element Seqn Id St Int Rpt
IVLAILELLKYHQRVLY HDA1_CHICK 156 20 -
IVLAILELLKYHQRVLY HDA1_HUMAN 156 20 -
IVLAILELLKYHQRVLY HDA2_CHICK 157 20 -
IVLAILELLKYHQRVLY HDA2_MOUSE 157 20 -
IVLAILELLKYHQRVLY HDA1_STRPU 155 20 -
IVLAILELLKYHQRVLY HDA2_HUMAN 157 20 -
IVLGILELLKYHKRVLY HDA1_CAEEL 160 20 -
IVLAILELLKQHERVLY HDAC_ARATH 164 20 -
IVIGILELLKYHPRVLY HDA3_CHICK 150 20 -
IVIGILELLKYHPRVLY HDA3_HUMAN 150 20 -
IVLGILELLKYHKRVLY HDA2_CAEEL 177 20 -

Motif 6 width=14
Element Seqn Id St Int Rpt
GAGKGKYYAVNYPL HDA1_CHICK 215 42 -
GAGKGKYYAVNYPL HDA1_HUMAN 215 42 -
GAGKGKYYAVNFPM HDA2_CHICK 216 42 -
GAGKGKYYAVNFPM HDA2_MOUSE 216 42 -
GAGKGKYYAVNFPL HDA1_STRPU 214 42 -
GAGKGKYYAVNFPM HDA2_HUMAN 216 42 -
GAGKGKLYSVNVPL HDA1_CAEEL 219 42 -
GYGSGKYYSLNVPL HDAC_ARATH 223 42 -
GAESGRYYALNVPL HDA3_CHICK 210 43 -
GAESGRYYCLNVPL HDA3_HUMAN 210 43 -
GVGPGKYFAINVPL HDA2_CAEEL 236 42 -

Motif 7 width=19
Element Seqn Id St Int Rpt
IDDESYEAIFKPVISKVME HDA1_CHICK 232 3 -
IDDESYEAIFKPVMSKVME HDA1_HUMAN 232 3 -
IDDESYGQIFKPIISKVME HDA2_CHICK 233 3 -
IDDESYGQIFKPIISKVME HDA2_MOUSE 233 3 -
IDDESYDKIFKPIMCKVME HDA1_STRPU 231 3 -
IDDESYGQIFKPIISKVME HDA2_HUMAN 233 3 -
ITDVSYQSIFKPIMTKVME HDA1_CAEEL 236 3 -
IDDESYHLLFKPIMGKVME HDAC_ARATH 240 3 -
IDDQSYKHLFQPVINQVVD HDA3_CHICK 227 3 -
IDDQSYKHLFQPVINQVVD HDA3_HUMAN 227 3 -
IRDEPYLKLFESVISGVEE HDA2_CAEEL 253 3 -
Final Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
MKPHRIRMTHNLLLNYGL HDA1_CHICK 30 30 -
MKPHRIRMTHNLLLNYGL HDA1_HUMAN 30 30 -
MKPHRIRMTHNLLLNYGL HDA1_MOUSE 30 30 -
MKPHRIRMTHNLLLNYGL HDA2_CHICK 31 31 -
MKPHRIRMTHNLLLNYGL HDA2_MOUSE 31 31 -
MKPHRIRMTHNLILNYGL HDA1_STRPU 29 29 -
MKPHRIRMTHNLLLNYGL HD12_XENLA 30 30 -
MKPHRIRMTHNLLLNYGL HDA2_HUMAN 31 31 -
MKPHRIRMTHNLLLNYGL HD11_XENLA 30 30 -
MKPHRIRMTHNLLLNYGL O77213 28 28 -
MKPHRIRMTHNLLLNYGL HDAC_DROME 28 28 -
MKPHRIRMTHHLVLNYGL HDA1_CAEEL 34 34 -
MKPHRIRMTHALLAHYGL HDAC_ARATH 38 38 -
MKPHRLALTHSLVLHYGL HDA3_CHICK 24 24 -
MKPHRLALTHSLVLHYGL O88895 24 24 -
MKPHRLALTHSLVLHYGL HDA3_HUMAN 24 24 -
MKPHRLALTHSLVLHYGL O43268 25 25 -
MKPHRVRMTHSLIVNYGL O62339 29 29 -
MKPHRVRMVHNLVVNYNL O59702 27 27 -
MKPQRLAVTHSLVMNYGL O96519 25 25 -
MKPHRIRMAHSLVVHYGL Q9ZTP8 43 43 -
MKPHRIRMTHSLLARYGL HDAC_MAIZE 44 44 -
MKPHRIRMAHSLIMNYGL RPD3_YEAST 40 40 -
MKPHRITITNHLVMGYGL PHD1_SCHPO 47 47 -
MKPQRLVVCNDLVVSYEM HDA2_CAEEL 50 50 -
MKPFRLMLTDHLVSSYGL HOS2_YEAST 47 47 -

Motif 2 width=19
Element Seqn Id St Int Rpt
EMTKYHSDDYIKFLRSIRP HDA1_CHICK 63 15 -
EMTKYHSDDYIKFLRSIRP HDA1_HUMAN 63 15 -
EMTKYHSDDYIKFLRSIRP HDA1_MOUSE 63 15 -
EMTKYHSDEYIKFLRSIRP HDA2_CHICK 64 15 -
EMTKYHSDEYIKFLRSIRP HDA2_MOUSE 64 15 -
EMTKYHSDDYVKFLRTIRP HDA1_STRPU 62 15 -
EMTKYHSDDYIKFLRSIRP HD12_XENLA 63 15 -
EMTKYHSDEYIKFLRSIRP HDA2_HUMAN 64 15 -
DMTKYHSDDYIKFLRSIRP HD11_XENLA 63 15 -
EMTKFHSDEYVRFLRSIRP O77213 61 15 -
EMTKFHCDEYVRFLRSIRP HDAC_DROME 60 14 -
DMTRFHSDEYMTFLKSANP HDA1_CAEEL 67 15 -
DLCRFHADDYVSFLRSITP HDAC_ARATH 71 15 -
DMCRFHSEDYIDFLQRVSP HDA3_CHICK 57 15 -
DMCRFHSEDYIDFLQRVSP O88895 57 15 -
DMCRFHSEDYIDFLQRVSP HDA3_HUMAN 57 15 -
DMCRFHSEDYIDFLQRVSP O43268 58 15 -
EITRYHSDDYINFLRNVKS O62339 62 15 -
DMTRCHTDEYIEFLWRVTP O59702 60 15 -
DMLRFHSDEYIAYLQQVTP O96519 58 15 -
DIRRFHSDDYVAFLASATG Q9ZTP8 76 15 -
ELCRFHAEEYINFLRSVTP HDAC_MAIZE 77 15 -
EMCQFHTDEYIDFLSRVTP RPD3_YEAST 73 15 -
EMSEFHREDYLDFLKRVTP PHD1_SCHPO 80 15 -
DISVFHTEDYVNFLQTVTP HDA2_CAEEL 83 15 -
ELLQFHSEDYVNFLSKVSP HOS2_YEAST 80 15 -

Motif 3 width=18
Element Seqn Id St Int Rpt
FNVGEDCPVFDGLFEFCQ HDA1_CHICK 94 12 -
FNVGEDCPVFDGLFEFCQ HDA1_HUMAN 94 12 -
FNVGEDCPVFDGLFEFCQ HDA1_MOUSE 94 12 -
FNVGEDCPVFDGLFEFCQ HDA2_CHICK 95 12 -
FNVGEDCPVFDGLFEFCQ HDA2_MOUSE 95 12 -
FNVGEDCPVFDGLYEFCQ HDA1_STRPU 93 12 -
FNVGEDCPVFDGLFEFCQ HD12_XENLA 94 12 -
FNVGEDCPAFDGLFEFCQ HDA2_HUMAN 95 12 -
FNVGEDCPVFDGLFEFCQ HD11_XENLA 94 12 -
FNVGEDCPVFDGLYEFCQ O77213 92 12 -
FNVGEDCPVFDGLYEFCQ HDAC_DROME 91 12 -
FNVGEDCPLFDGLYEFCQ HDA1_CAEEL 98 12 -
FNVGEDCPVFDGLYSFCQ HDAC_ARATH 102 12 -
FNVGDDCPVFPGLFEFCS HDA3_CHICK 88 12 -
FNVGDDCPVFPGLFEFCS O88895 88 12 -
FNVGDDCPVFPGLFEFCS HDA3_HUMAN 88 12 -
FNVGDDCPVFPGLFEFCS O43268 89 12 -
FSVGEDCPVFDGMYEFCQ O62339 93 12 -
FNVGDDCPVFDGLYEFCS O59702 91 12 -
FSVGEDCPVFDGLFDFCA O96519 93 16 -
FNVGEDCPVFDGLFPFCQ Q9ZTP8 107 12 -
FNVGEECPVLDGLYSFCQ HDAC_MAIZE 108 12 -
FNVGDDCPVFDGLYEYCS RPD3_YEAST 104 12 -
FNIGDDCPVFDGTYEFSQ PHD1_SCHPO 111 12 -
FNIGEDCPIFAGLWDYCT HDA2_CAEEL 115 13 -
FNIGDDCPIFQNLYDYTT HOS2_YEAST 112 13 -

Motif 4 width=21
Element Seqn Id St Int Rpt
GGSVASAVKLNKQQTDIAVNW HDA1_CHICK 115 3 -
GGSVASAVKLNKQQTDIAVNW HDA1_HUMAN 115 3 -
GGSVASAVKLNKQQTDIAVNW HDA1_MOUSE 115 3 -
GGSVAGAVKLNRQQTDMAVNW HDA2_CHICK 116 3 -
GGSVAGAVKLNRQQTDMAVNW HDA2_MOUSE 116 3 -
GGSVAGAVKLNKQQTDIAINW HDA1_STRPU 114 3 -
GGSVASAVKLNKQQTDISVNW HD12_XENLA 115 3 -
GGSVAGAVKLNRQQTDMAVNW HDA2_HUMAN 116 3 -
GGSVASAVKLNKQQTDISVNW HD11_XENLA 115 3 -
GGSVAAAVKLNKQASEICINW O77213 113 3 -
GGSVAAAVKLNKQASEICINW HDAC_DROME 112 3 -
GGSLAAATKLNKQKVDIAINW HDA1_CAEEL 119 3 -
GGSVGGSVKLNHGLCDIAINW HDAC_ARATH 123 3 -
GASLQGATQLNNKICDIAINW HDA3_CHICK 109 3 -
GASLQGATQLNNKICDIAINW O88895 109 3 -
GASLQGATQLNNKICDIAINW HDA3_HUMAN 109 3 -
GASLQGATQLNNKICDIAINW O43268 110 3 -
GGSLAAAARLNRQESEIAINW O62339 114 3 -
GGSIGAAQELNSGNAEIAINW O59702 112 3 -
GASLEGAQKLNHNHSDICINW O96519 114 3 -
GGSIGAAVKLNRGDADITVNW Q9ZTP8 128 3 -
GASVGGAVKFNHGHDIAINWS HDAC_MAIZE 129 3 -
GGSMEGAARLNRGKCDVAVNY RPD3_YEAST 125 3 -
GASLDASRKLVQGQTDIAINW PHD1_SCHPO 132 3 -
GGSVEGARRLNHKMNDIVINW HDA2_CAEEL 136 3 -
GASLDATRKLINNQSDIAINW HOS2_YEAST 133 3 -

Motif 5 width=17
Element Seqn Id St Int Rpt
IVLAILELLKYHQRVLY HDA1_CHICK 156 20 -
IVLAILELLKYHQRVLY HDA1_HUMAN 156 20 -
IVLAILELLKYHQRVLY HDA1_MOUSE 156 20 -
IVLAILELLKYHQRVLY HDA2_CHICK 157 20 -
IVLAILELLKYHQRVLY HDA2_MOUSE 157 20 -
IVLAILELLKYHQRVLY HDA1_STRPU 155 20 -
IVLAILELLKYHQRVVY HD12_XENLA 156 20 -
IVLAILELLKYHQRVLY HDA2_HUMAN 157 20 -
IVLAILELLKYHQRVVY HD11_XENLA 156 20 -
IVLGILELLKYHQRVLY O77213 154 20 -
IVLGILELLKYHQRVLY HDAC_DROME 153 20 -
IVLGILELLKYHKRVLY HDA1_CAEEL 160 20 -
IVLAILELLKQHERVLY HDAC_ARATH 164 20 -
IVIGILELLKYHPRVLY HDA3_CHICK 150 20 -
IVIGILELLKYHPRVLY O88895 150 20 -
IVIGILELLKYHPRVLY HDA3_HUMAN 150 20 -
IVIGILELLKYHPRVLY O43268 151 20 -
IVLAILELLKHHKRVLY O62339 155 20 -
IALAALELLKYHQRVLY O59702 153 20 -
IVIGILELLKYHPRVLY O96519 155 20 -
IVLAILELLKFHRRVLY Q9ZTP8 169 20 -
IVLAILELLKHHERVLY HDAC_MAIZE 169 19 -
IVLGIIELLRYHPRVLY RPD3_YEAST 166 20 -
IVLAILNMLRFFPRVLY PHD1_SCHPO 173 20 -
IVLGILELLKYHKRVLY HDA2_CAEEL 177 20 -
IVLSILNLLRYHPRILY HOS2_YEAST 174 20 -

Motif 6 width=14
Element Seqn Id St Int Rpt
GAGKGKYYAVNYPL HDA1_CHICK 215 42 -
GAGKGKYYAVNYPL HDA1_HUMAN 215 42 -
GAGKGKYYAVNYPL HDA1_MOUSE 215 42 -
GAGKGKYYAVNFPM HDA2_CHICK 216 42 -
GAGKGKYYAVNFPM HDA2_MOUSE 216 42 -
GAGKGKYYAVNFPL HDA1_STRPU 214 42 -
GAGKGKYYAVNYPL HD12_XENLA 215 42 -
GAGKGKYYAVNFPM HDA2_HUMAN 216 42 -
GAGKGKYYAVNYAL HD11_XENLA 215 42 -
GAGKGKYYAVNIPL O77213 213 42 -
GAGKGKYYAVNIPL HDAC_DROME 212 42 -
GAGKGKLYSVNVPL HDA1_CAEEL 219 42 -
GYGSGKYYSLNVPL HDAC_ARATH 223 42 -
GAESGRYYALNVPL HDA3_CHICK 210 43 -
GAESGRYYCLNVPL O88895 210 43 -
GAESGRYYCLNVPL HDA3_HUMAN 210 43 -
GAESGRYYCLNVPL O43268 211 43 -
GAGSGKYYALNVPL O62339 214 42 -
GIGTGKNYAVNVPL O59702 212 42 -
GAESGRYYSVNVPL O96519 215 43 -
GAAEGKHYALNVPL Q9ZTP8 228 42 -
GHSKGKYYSLNVPL HDAC_MAIZE 228 42 -
GVGAGKNYAVNVPL RPD3_YEAST 225 42 -
GVKGGKYFALNVPL PHD1_SCHPO 233 43 -
GVGPGKYFAINVPL HDA2_CAEEL 236 42 -
GCDKGKHFALNVPL HOS2_YEAST 234 43 -

Motif 7 width=19
Element Seqn Id St Int Rpt
IDDESYEAIFKPVISKVME HDA1_CHICK 232 3 -
IDDESYEAIFKPVMSKVME HDA1_HUMAN 232 3 -
IDDESYEAIFKPVMSKVME HDA1_MOUSE 232 3 -
IDDESYGQIFKPIISKVME HDA2_CHICK 233 3 -
IDDESYGQIFKPIISKVME HDA2_MOUSE 233 3 -
IDDESYDKIFKPIMCKVME HDA1_STRPU 231 3 -
IDDESYEAIFKPVMTKVME HD12_XENLA 232 3 -
IDDESYGQIFKPIISKVME HDA2_HUMAN 233 3 -
IDDESYEAIFKPVMSKVME HD11_XENLA 232 3 -
MDDDAYESIFVPIISKVME O77213 230 3 -
MDDDAYESIFVPIISKVME HDAC_DROME 229 3 -
ITDVSYQSIFKPIMTKVME HDA1_CAEEL 236 3 -
IDDESYHLLFKPIMGKVME HDAC_ARATH 240 3 -
IDDQSYKHLFQPVINQVVD HDA3_CHICK 227 3 -
IDDQSYKHLFQPVISQVVD O88895 227 3 -
IDDQSYKHLFQPVINQVVD HDA3_HUMAN 227 3 -
IDDQSYKHLFQPVINQVVD O43268 228 3 -
VDDVTYERIFRTIMGEVMA O62339 231 3 -
IDDESYESVFKPVISHIMQ O59702 229 3 -
IDDQSYFQVFKPIISAIMD O96519 232 3 -
IDDTTFRGLFQCIIKKVME Q9ZTP8 245 3 -
IDDESYQSLFKPIMGKVME HDAC_MAIZE 245 3 -
IDDATYRSVFEPVIKKIME RPD3_YEAST 242 3 -
IGDEQYTSLFKSIIEPTIN PHD1_SCHPO 250 3 -
IRDEPYLKLFESVISGVEE HDA2_CAEEL 253 3 -
IDDDSYINLFKSIVDPLIM HOS2_YEAST 251 3 -