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PR01270

Identifier
HDASUPER  [View Relations]  [View Alignment]  
Accession
PR01270
No. of Motifs
3
Creation Date
16-FEB-2000
Title
Histone deacetylase superfamily signature
Database References
PRINTS; PR01272 ACUCPROTEIN; PR01271 HISDACETLASE
PFAM; PF00850 Hist_deacetyl
PDB; 1C3P; 1C3R; 1C3S
SCOP; 1C3P; 1C3R; 1C3S
CATH; 1C3P; 1C3R; 1C3S
Literature References
1. LEIPE, D.D. AND LANDSMAN, D.
Histone deacetylases, acetoin utilisation proteins and acetylpolyamine
amidohydrolases are members of an ancient protein superfamily.
NUCLEIC ACIDS RES. 25 3693-3697 (1997).
 
2. JOHNSON, C.A. AND TURNER, B.M.
Histone deacetylases: complex transducers of nuclear signals.
SEMIN.CELL DEV.BIOL. 10 179-188 (1999).
 
3. FINNIN, M.S., DONIGIAN J.R., COHEN, A., RICHON, V.M., RIFKIND, R.A.,
MARKS, P.A., BRESLOW, R. AND PAVLETICH, N.P.
Structures of a histone deacetylase homologue bound to the TSA and SAHA
inhibitors.
NATURE 401 188-193 (1999).
 
4. AYER, D.E.
Histone deacetylases: transcriptional repression with SINers and NuRDs.
TRENDS CELL BIOL. 9 193-198 (1999).
 
5. KOUZARIDES, T.
Histone acetylases and deacetylases in cell proliferation.
CURR.OPIN.GENET.DEV. 9 40-48 (1999).
 
6. ARCHER, S.Y. AND HODIN, R.A.
Histone acetylation and cancer.
CURR.OPIN.GENET.DEV. 9 171-174 (1999).

Documentation
Histone deacetylases (HDA), acetoin utilisation proteins (ACUC) and
acetylpolyamine amidohydrolases (APHA) form an ancient protein superfamily
and are all believed to catalyse the deacetylation of a substrate [1]. HDAs
are found in eukaryotes, from yeast to humans; ACUCs are found in 
eubacteria; and APHAs occur in archaeal bacteria, eubacteria and some
eukaryotic organisms [1]. HDA nomenclature is confusing: the family
can also be identified by the codes RPD, HOS, HD and HDAC, regardless of
specific sequence similarities [1]. HDAs may have evolved at least twice
from APHAs, the more recent gene duplication event resembling APHAs more 
closely [1].
 
Only the most highly conserved regions in the group of HDAs including RPD3
are similar to regions in the prokaryotic enzymes [2]. Many of the invariant
residues are histidine, glycine, cysteine, aspartic acid or glutamic acid,
and may be essential for maintaining structural integrity or catalytic
activity [1,2]. Histidines and acidic amino acids may be required for the
co-ordination of metal ion cofactors; APHA is known to contain one zinc ion
that is necessary for catalysis [2].
 
The crystal structure of a HDA homologue from the hyperthermophilic
bacterium Aquifex aeolicus has revealed that it has a single domain
structure belonging to the open alpha/beta class of folds [3]. It consists
of a central eight-stranded parallel beta-sheet and 16 alpha-helices [3].
Seven loops form an active site comprising a tubular pocket, a zinc-binding
site and two Asp-His charge relay systems; thus the active site has features
of metalloproteases and serine proteases [3].
 
HDASUPER is a 3-element fingerprint that provides a signature for the
histone deacetylase superfamily. The fingerprint was derived from an initial
alignment of 13 sequences: the motifs were drawn from conserved regions
spanning the C-terminal portion of the alignment - motif 1 encodes the loop
between beta-strand 3 and alpha-helix 9; motif 2 spans strand 4 and the
following loop; and motif 3 includes strand 7 and part of the loop between
this and helix 13. Two iterations on SPTR37_10f were required to reach
convergence, at which point a true set comprising 52 sequences was
identified. 
Summary Information
52 codes involving  3 elements
0 codes involving 2 elements
Composite Feature Index
3525252
2000
123
True Positives
ACUC_BACSU    ACUC_STAXY    APHA_MYCRA    HD11_XENLA    
HD12_XENLA HDA1_CAEEL HDA1_CHICK HDA1_HUMAN
HDA1_MOUSE HDA1_SCHPO HDA1_STRPU HDA1_YEAST
HDA2_CAEEL HDA2_CHICK HDA2_HUMAN HDA2_MOUSE
HDA3_CHICK HDA3_HUMAN HDAC_ARATH HDAC_DROME
HDAC_MAIZE HOS1_YEAST HOS2_YEAST HOS3_YEAST
O17323 O27994 O28982 O29567
O43268 O58986 O59702 O62339
O67135 O67877 O77213 O88895
O94975 O96519 PHD1_SCHPO Q20373
Q44173 Q9Z2V5 Q9Z2V6 Q9ZTP8
RPD3_YEAST Y130_ARCFU Y245_SYNY3 Y288_HUMAN
Y535_METJA YB94_METTH YGLA_SYNP2 YLFN_CAEEL
Sequence Titles
ACUC_BACSU  ACETOIN UTILIZATION ACUC PROTEIN - BACILLUS SUBTILIS. 
ACUC_STAXY ACETOIN UTILIZATION ACUC PROTEIN - STAPHYLOCOCCUS XYLOSUS.
APHA_MYCRA ACETYLPOLYAMINE AMINOHYDROLASE - MYCOPLANA RAMOSA (MYCOPLANA BULLATA).
HD11_XENLA PROBABLE HISTONE DEACETYLASE 1-1 (HD1) (MATERNALLY-EXPRESSED HISTONE DEACETYLASE) (HDM) (AB21) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
HD12_XENLA PROBABLE HISTONE DEACETYLASE 1-2 (HD1) (RPD3 HOMOLOG) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
HDA1_CAEEL PROBABLE HISTONE DEACETYLASE 1 - CAENORHABDITIS ELEGANS.
HDA1_CHICK HISTONE DEACETYLASE 1 (HD1) - GALLUS GALLUS (CHICKEN).
HDA1_HUMAN HISTONE DEACETYLASE 1 (HD1) - HOMO SAPIENS (HUMAN).
HDA1_MOUSE HISTONE DEACETYLASE 1 (HD1) - MUS MUSCULUS (MOUSE).
HDA1_SCHPO HYPOTHETICAL 76.8 KD PROTEIN IN CHROMOSOME II - SCHIZOSACCHAROMYCES POMBE (FISSI
HDA1_STRPU HISTONE DEACETYLASE 1 (HD1) - STRONGYLOCENTROTUS PURPURATUS (PURPLE SEA URCHIN).
HDA1_YEAST HISTONE DEACETYLASE HDA1 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HDA2_CAEEL PUTATIVE HISTONE DEACETYLASE C08B11.2 - CAENORHABDITIS ELEGANS.
HDA2_CHICK HISTONE DEACETYLASE 2 (HD2) - GALLUS GALLUS (CHICKEN).
HDA2_HUMAN HISTONE DEACETYLASE 2 (HD2) - HOMO SAPIENS (HUMAN).
HDA2_MOUSE HISTONE DEACETYLASE 2 (HD2) (YY1 TRANSCRIPTION FACTOR BINDING PROTEIN) - MUS MUSCULUS (MOUSE).
HDA3_CHICK HISTONE DEACETYLASE 3 (HD3) - GALLUS GALLUS (CHICKEN).
HDA3_HUMAN HISTONE DEACETYLASE 3 (HD3) - HOMO SAPIENS (HUMAN).
HDAC_ARATH HISTONE DEACETYLASE (HD) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
HDAC_DROME PROBABLE HISTONE DEACETYLASE (HD) (DRPD3) - DROSOPHILA MELANOGASTER (FRUIT FLY).
HDAC_MAIZE PROBABLE HISTONE DEACETYLASE (RPD3 HOMOLOG) - ZEA MAYS (MAIZE).
HOS1_YEAST HOS1 PROTEIN - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HOS2_YEAST PROBABLE HISTONE DEACETYLASE HOS2 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HOS3_YEAST HOS3 PROTEIN - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
O17323 C10E2.3 PROTEIN - CAENORHABDITIS ELEGANS.
O27994 ACETYLPOLYAMINE AMINOHYDROLASE, PUTATIVE - ARCHAEOGLOBUS FULGIDUS.
O28982 ACETOIN UTILIZATION PROTEIN, PUTATIVE - ARCHAEOGLOBUS FULGIDUS.
O29567 HYPOTHETICAL 28.9 KD PROTEIN - ARCHAEOGLOBUS FULGIDUS.
O43268 RPD3-2A - HOMO SAPIENS (HUMAN).
O58986 335AA LONG HYPOTHETICAL PROTEIN - PYROCOCCUS HORIKOSHII.
O59702 HISTONE DEACETYLASE - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O62339 R06C1.1 PROTEIN - CAENORHABDITIS ELEGANS.
O67135 ACETOIN UTILIZATION PROTEIN - AQUIFEX AEOLICUS.
O67877 ACETOIN UTILIZATION PROTEIN - AQUIFEX AEOLICUS.
O77213 PUTATIVE HISTONE DEACETYLASE - DROSOPHILA MELANOGASTER (FRUIT FLY).
O88895 HISTONE DEACETYLASE 3 - MUS MUSCULUS (MOUSE).
O94975 KIAA0901 PROTEIN - HOMO SAPIENS (HUMAN).
O96519 HISTONE DEACETYLASE DHDAC3 - DROSOPHILA MELANOGASTER (FRUIT FLY).
PHD1_SCHPO PROBABLE HISTONE DEACETYLASE PHD1 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
Q20373 F43G6.4 PROTEIN - CAENORHABDITIS ELEGANS.
Q44173 HYPOTHETICAL 33.0 KD PROTEIN - SYNECHOCOCCUS SP. (STRAIN PCC 7002) (AGMENELLUM Q
Q9Z2V5 HISTONE DEACETYLASE MHDA2 - MUS MUSCULUS (MOUSE).
Q9Z2V6 HISTONE DEACETYLASE MHDA1 - MUS MUSCULUS (MOUSE).
Q9ZTP8 HISTONE DEACETYLASE - ZEA MAYS (MAIZE).
RPD3_YEAST HISTONE DEACETYLASE RPD3 (TRANSCRIPTIONAL REGULATORY PROTEIN RPD3) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
Y130_ARCFU HYPOTHETICAL PROTEIN AF0130 - ARCHAEOGLOBUS FULGIDUS.
Y245_SYNY3 HYPOTHETICAL 33.6 KD PROTEIN SLR0245 - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
Y288_HUMAN HYPOTHETICAL PROTEIN KIAA0288 (HA6116) - HOMO SAPIENS (HUMAN).
Y535_METJA HYPOTHETICAL PROTEIN MJ0535 - METHANOCOCCUS JANNASCHII.
YB94_METTH HYPOTHETICAL PROTEIN MTH1194 - METHANOBACTERIUM THERMOAUTOTROPHICUM.
YGLA_SYNP2 HYPOTHETICAL 34.1 KD PROTEIN IN GLNA 3'REGION - SYNECHOCOCCUS SP. (STRAIN PCC 70
YLFN_CAEEL HYPOTHETICAL 89.8 KD PROTEIN F41H10.6 IN CHROMOSOME IV - CAENORHABDITIS ELEGANS.
Scan History
SPTR37_10f 2  264  NSINGLE    
Initial Motifs
Motif 1  width=24
Element Seqn Id St Int Rpt
GGLHHAKKFEASGFCYVNDIVIGI HDA3_HUMAN 131 131 -
GGLHHGFRGRASGFCIYNDSAVAI ACUC_BACSU 129 129 -
PPGHHASASKSSGFCIFNNVAVAA YLFN_CAEEL 557 557 -
PPGHHAEPHKPGGFCLFNNVSVTA HDA1_SCHPO 191 191 -
PPGHHAEESTAMGFCFFNSVAITA Q9Z2V6 698 698 -
GGMHHAFKSRANGFCYINDPAVGI O67135 128 128 -
GGRHHAFKQRASGFCYINDVVLLI HOS1_YEAST 207 207 -
PPGHHAEESTPMGFCYFNSVAVAA Y288_HUMAN 682 682 -
GGLHHSLPGRANGFCIYNDVAITI ACUC_STAXY 133 133 -
GGTHHAFPGYGSGFCILNDLAIAT YGLA_SYNP2 127 127 -
PPGHHAIRNTGMGFCLLNNVAIAA Y245_SYNY3 122 122 -
PPGHHAKPYIGAGFCYLNNMAIMV Y130_ARCFU 122 122 -
AGGHHAGRDYFWGYCCFNDVVLAI O28982 16 16 -

Motif 2 width=16
Element Seqn Id St Int Rpt
RVLYIDIDIHHGDGVQ HDA3_HUMAN 163 8 -
RVLYIDTDAHHGDGVQ ACUC_BACSU 162 9 -
RVLILDWDVHHGNGTQ YLFN_CAEEL 591 10 -
RVLIVDWDIHHGNGTQ HDA1_SCHPO 227 12 -
KVLIVDWDIHHGNGTQ Q9Z2V6 732 10 -
RILYIDLDAHHCDGVQ O67135 161 9 -
KITYVDFDLHHGDGVE HOS1_YEAST 240 9 -
KILIVDWDVHHGNGTQ Y288_HUMAN 716 10 -
RVLCIDTDAHHGDGTQ ACUC_STAXY 166 9 -
RILIVDLDVHQGDGTA YGLA_SYNP2 161 10 -
RVAILDWDVHHGNGTE Y245_SYNY3 156 10 -
RIAILDWDAHHGDGTQ Y130_ARCFU 155 9 -
RVAIIDTDAHHGDGTR O28982 50 10 -

Motif 3 width=11
Element Seqn Id St Int Rpt
PTCIVLQCGAD HDA3_HUMAN 249 70 -
PDVIISQNGAD ACUC_BACSU 248 70 -
PDLVLISAGFD YLFN_CAEEL 681 74 -
PDLVIVSCGFD HDA1_SCHPO 317 74 -
PDVVLVSAGFD Q9Z2V6 823 75 -
PEVYLLQLGTD O67135 248 71 -
PEALIIECGGD HOS1_YEAST 323 67 -
PDVVLVSSGFD Y288_HUMAN 807 75 -
PDIIVSVHGVD ACUC_STAXY 252 70 -
PDLVFYDAGVD YGLA_SYNP2 235 58 -
PDLLLVSAGYD Y245_SYNY3 237 65 -
PQFIAISAGQD Y130_ARCFU 239 68 -
PDILFWYFGHD O28982 118 52 -
Final Motifs
Motif 1  width=24
Element Seqn Id St Int Rpt
GGLHHAKKSEASGFCYVNDIVLAI HDA2_CHICK 138 138 -
GGLHHAKKSEASGFCYVNDIVLAI HDA2_MOUSE 138 138 -
GGLHHAKKYEASGFCYVNDIVLAI HDA2_HUMAN 138 138 -
GGLHHAKKSEASGFCYSNDIVLAI O62339 136 136 -
GGLHHAKKSEASGFCYVNDIVLAI HDA1_CHICK 137 137 -
GGLHHAKKSEASGFCYVNDIVLAI HDA1_MOUSE 137 137 -
GGLHHAKKSEASGFCYVNDIVLAI HDA1_HUMAN 137 137 -
GGLHHAKKSEASGFCYVNDIVLAI HD11_XENLA 137 137 -
GGLHHAKKSEASGFCYVNDIVLAI HD12_XENLA 137 137 -
GGLHHAKKSEASGFCYVNDIVLGI HDAC_DROME 134 134 -
GGLHHAKKSEASGFCYVNDIVLGI O77213 135 135 -
GGLHHAKKSEASGFCYVNDIVLAI Q9ZTP8 150 150 -
GGLHHAKKCEASGFCYVNDIVLAI HDAC_ARATH 145 145 -
GGLHHAKKCEASGFCYVNDIVLAI HDAC_MAIZE 150 150 -
GGLHHAKRGEASGFCYVNDIVLAI PHD1_SCHPO 154 154 -
GGLHHAKKSEASGFCYLNDIVLGI RPD3_YEAST 147 147 -
GGLHHAKKSEASGFCYTNDIVLGI HDA1_CAEEL 141 141 -
GGLHHAKKSEASGFCYVNDIVLGI HDA2_CAEEL 158 158 -
GGLHHAKKSEASGFCYVNDIVLAI HDA1_STRPU 136 136 -
GGLHHAKKFEASGFCYVNDIVIGI HDA3_CHICK 131 131 -
GGLHHAKKFEASGFCYVNDIVIGI O88895 131 131 -
GGLHHAKKFEASGFCYVNDIVIGI O43268 132 132 -
GGLHHAKKFEASGFCYVNDIVIGI HDA3_HUMAN 131 131 -
GGLHHAKKFEASGFCYVDDIVIGI O96519 136 136 -
GGLHHAKKREASGFCYVNDIALAA O59702 134 134 -
GGLHHAKKNSPSGFCYVNDIVLSI HOS2_YEAST 155 155 -
GGLHHGFRGRASGFCIYNDSAVAI ACUC_BACSU 129 129 -
PPGHHASASKSSGFCIFNNVAVAA YLFN_CAEEL 557 557 -
PPGHHAEPHKPGGFCLFNNVSVTA HDA1_SCHPO 191 191 -
PPGHHAEQDAACGFCFFNSVAVAA O94975 607 607 -
PPGHHAEPNAACGFCFFNSVAVAA Q9Z2V5 552 552 -
PPGHHAEESTAMGFCFFNSVAITA Q9Z2V6 698 698 -
GGMHHAFKSRANGFCYINDPAVGI O67135 128 128 -
GGRHHAFKQRASGFCYINDVVLLI HOS1_YEAST 207 207 -
PPGHHAEESTPMGFCYFNSVAVAA Y288_HUMAN 682 682 -
GGLHHSLPGRANGFCIYNDVAITI ACUC_STAXY 133 133 -
PPGHHAEYAKAMGFCIFNNVAIGA O67877 121 121 -
PPGHHAEHEQAMGFCFFNNVAVAV O17323 534 534 -
PPGHHATYDRSMGFCIFNNIAIAI YB94_METTH 114 114 -
PPGHHAEPQAAGGFCLFSNVAVAA HDA1_YEAST 202 202 -
GGTHHAFPGYGSGFCILNDLAIAT Q44173 117 117 -
GGTHHAFPGYGSGFCILNDLAIAT YGLA_SYNP2 127 127 -
PPGHHAIRNTGMGFCLLNNVAIAA Y245_SYNY3 122 122 -
GISGRALGAMSNGFCIFNNIAGAA Y535_METJA 126 126 -
PPGHHAKPYIGAGFCYLNNMAIMV Y130_ARCFU 122 122 -
AGGHHAGRDYFWGYCCFNDVVLAI O28982 16 16 -
PPGHHCHYGTPSGFCLLNNAHVAI HOS3_YEAST 192 192 -
GRRGRALGAPTLGFCIFNNSAMAA O58986 124 124 -
PPGHHSYGKVAQGYCIFNNVAIAA Q20373 404 404 -
PPGHHASPDSSWGFCYFNNIAIAV O27994 38 38 -
PPGHHAGIDMFGGYCFINNAAVAA APHA_MYCRA 155 155 -
TAGHLAEQSRMRGYCLLNGLAIAV O29567 91 91 -

Motif 2 width=16
Element Seqn Id St Int Rpt
RVLYIDIDIHHGDGVE HDA2_CHICK 170 8 -
RVLYIDIDIHHGDGVE HDA2_MOUSE 170 8 -
RVLYIDIDIHHGDGVE HDA2_HUMAN 170 8 -
RVLYIDIDVHHGDGVE O62339 168 8 -
RVLYIDIDIHHGDGVE HDA1_CHICK 169 8 -
RVLYIDIDIHHGDGVE HDA1_MOUSE 169 8 -
RVLYIDIDIHHGDGVE HDA1_HUMAN 169 8 -
RVVYIDIDIHHGDGVE HD11_XENLA 169 8 -
RVVYIDIDIHHGDGVE HD12_XENLA 169 8 -
RVLYIDIDVHHGDGVE HDAC_DROME 166 8 -
RVLYIDIDVHHGDGVE O77213 167 8 -
RVLYVDIDVHHGDGVE Q9ZTP8 182 8 -
RVLYVDIDIHHGDGVE HDAC_ARATH 177 8 -
RVLYVDIDIHHGDGVE HDAC_MAIZE 182 8 -
RVLYIDIDIHHGDGVQ PHD1_SCHPO 186 8 -
RVLYIDIDVHHGDGVE RPD3_YEAST 179 8 -
RVLYVDIDVHHGDGVE HDA1_CAEEL 173 8 -
RVLYIDIDIHHGDGVQ HDA2_CAEEL 190 8 -
RVLYIDIDIHHGDGVE HDA1_STRPU 168 8 -
RVLYIDIDIHHGDGVQ HDA3_CHICK 163 8 -
RVLYIDIDIHHGDGVQ O88895 163 8 -
RVLYIDIDIHHGDGVQ O43268 164 8 -
RVLYIDIDIHHGDGVQ HDA3_HUMAN 163 8 -
RVLYIDIDVHHGDGVQ O96519 168 8 -
RVLYIDIDVHHGDGVE O59702 166 8 -
RILYIDIDLHHGDGVQ HOS2_YEAST 187 8 -
RVLYIDTDAHHGDGVQ ACUC_BACSU 162 9 -
RVLILDWDVHHGNGTQ YLFN_CAEEL 591 10 -
RVLIVDWDIHHGNGTQ HDA1_SCHPO 227 12 -
RILIVDWDVHHGNGTQ O94975 642 11 -
RILIVDWDVHHGNGTQ Q9Z2V5 587 11 -
KVLIVDWDIHHGNGTQ Q9Z2V6 732 10 -
RILYIDLDAHHCDGVQ O67135 161 9 -
KITYVDFDLHHGDGVE HOS1_YEAST 240 9 -
KILIVDWDVHHGNGTQ Y288_HUMAN 716 10 -
RVLCIDTDAHHGDGTQ ACUC_STAXY 166 9 -
KVFIIDFDAHHGNGTQ O67877 155 10 -
KIAIIDWDVHHGNGTQ O17323 570 12 -
RPLVLDFDVHHGNGTS YB94_METTH 148 10 -
RIMILDWDIHHGNGTQ HDA1_YEAST 238 12 -
RILIVDLDVHQGDGTA Q44173 151 10 -
RILIVDLDVHQGDGTA YGLA_SYNP2 161 10 -
RVAILDWDVHHGNGTE Y245_SYNY3 156 10 -
KVIIIDFDVHHGNGTQ Y535_METJA 158 8 -
RIAILDWDAHHGDGTQ Y130_ARCFU 155 9 -
RVAIIDTDAHHGDGTR O28982 50 10 -
HVVVLDFDLHHGDGTQ HOS3_YEAST 226 10 -
EALIIDFDAHHGNGTQ O58986 156 8 -
KVAIVDFDYHAGNGTY Q20373 438 10 -
KAVIVDFDLHFGDGTA O27994 72 10 -
KIAILDVDFHHGNGTQ APHA_MYCRA 188 9 -
RIAVIETDAHHGKASI O29567 122 7 -

Motif 3 width=11
Element Seqn Id St Int Rpt
PSAVVLQCGAD HDA2_CHICK 255 69 -
PSAVVLQCGAD HDA2_MOUSE 255 69 -
PSAVVLQCGAD HDA2_HUMAN 255 69 -
PEAVVLQCGAD O62339 253 69 -
PSAVVLQCGSD HDA1_CHICK 254 69 -
PSAVVLQCGSD HDA1_MOUSE 254 69 -
PSAVVLQCGSD HDA1_HUMAN 254 69 -
PSAVVLQCGAD HD11_XENLA 254 69 -
PSAVVLQCGAD HD12_XENLA 254 69 -
PAAVVLQCGAD HDAC_DROME 251 69 -
PAAVVLQCGAD O77213 252 69 -
PDVVVLQCGAD Q9ZTP8 267 69 -
PGAVVLQCGAD HDAC_ARATH 262 69 -
PGAVVLQCGAD HDAC_MAIZE 267 69 -
PSAIVLQCGAD PHD1_SCHPO 272 70 -
PSAVVLQCGGD RPD3_YEAST 264 69 -
PCAVVLQCGAD HDA1_CAEEL 258 69 -
PEAIVLQCGSD HDA2_CAEEL 275 69 -
PSAICLQCGAD HDA1_STRPU 253 69 -
PTCIVLQCGAD HDA3_CHICK 249 70 -
PTCIVLQCGAD O88895 249 70 -
PTCIVLQCGAD O43268 250 70 -
PTCIVLQCGAD HDA3_HUMAN 249 70 -
PTAIVLQCGAD O96519 254 70 -
PEAVILQCGTD O59702 251 69 -
PTLIVQQCGAD HOS2_YEAST 273 70 -
PDVIISQNGAD ACUC_BACSU 248 70 -
PDLVLISAGFD YLFN_CAEEL 681 74 -
PDLVIVSCGFD HDA1_SCHPO 317 74 -
PELVLVSAGFD O94975 732 74 -
PELVLISAGFD Q9Z2V5 677 74 -
PDVVLVSAGFD Q9Z2V6 823 75 -
PEVYLLQLGTD O67135 248 71 -
PEALIIECGGD HOS1_YEAST 323 67 -
PDVVLVSSGFD Y288_HUMAN 807 75 -
PDIIVSVHGVD ACUC_STAXY 252 70 -
PDFVLVSAGYD O67877 239 68 -
PDFIIVSAGFD O17323 658 72 -
PDMIFVSAGFD YB94_METTH 234 70 -
PDLVIISSGFD HDA1_YEAST 328 74 -
PDLVFYDAGVD Q44173 225 58 -
PDLVFYDAGVD YGLA_SYNP2 235 58 -
PDLLLVSAGYD Y245_SYNY3 237 65 -
PDTVLVSAGFD Y535_METJA 242 68 -
PQFIAISAGQD Y130_ARCFU 239 68 -
PDILFWYFGHD O28982 118 52 -
KGLVVISAGFD HOS3_YEAST 360 118 -
PKVIIVSAGFD O58986 240 68 -
PELILISAGFD Q20373 523 69 -
YDIVAVSAGFD O27994 118 30 -
AEAIVVSLGVD APHA_MYCRA 274 70 -
PNLVIWYLGLD O29567 187 49 -