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PR00657

Identifier
CCCHEMOKINER  [View Relations]  [View Alignment]  
Accession
PR00657
No. of Motifs
7
Creation Date
22-FEB-1997  (UPDATE 10-JUN-1999)
Title
Chemokine receptor signature
Database References
PRINTS; PR90007 7TM; PR90006 GPCRCLAN; PR00237 GPCRRHODOPSN
PRINTS; PR01106 CHEMOKINER1; PR01557 CHEMOKINER10; PR01558 CHEMOKINER11
PRINTS; PR01107 CHEMOKINER2; PR01108 CHEMOKINER3; PR01109 CHEMOKINER4
PRINTS; PR01110 CHEMOKINER5; PR01529 CHEMOKINER6; PR00641 CHEMOKINER7
PRINTS; PR01530 CHEMOKINER8; PR01531 CHEMOKINER9; PR01532 CXCCHMKINER3
PRINTS; PR00564 CXCCHMKINER5; PR01105 CXCCHMKINER6
INTERPRO; IPR000355
Literature References
1. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994).
 
2. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
G protein-coupled receptor fingerprints.
7TM, VOLUME 2, EDS. G.VRIEND AND B.BYWATER (1993).
 
3. BIRNBAUMER, L.
G proteins in signal transduction.
ANNU.REV.PHARMACOL.TOXICOL. 30 675-705 (1990).
 
4. CASEY, P.J. AND GILMAN, A.G.
G protein involvement in receptor-effector coupling.
J.BIOL.CHEM. 263(6) 2577-2580 (1988).
 
5. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Design of a discriminating fingerprint for G protein-coupled receptors.
PROTEIN ENG. 6(2) 167-176 (1993).
 
6. WATSON, S. AND ARKINSTALL, S.
Chemokines.
IN THE G PROTEIN-LINKED RECEPTOR FACTSBOOK, ACADEMIC PRESS, 1994, PP.83-88.

Documentation
G protein-coupled receptors (GPCRs) constitute a vast protein family that 
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the 
sequence level, on the basis of which they can be separated into distinct 
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship, 
but between which there is no statistically significant similarity in 
sequence [1]. The currently known clan members include the rhodopsin-like 
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
 
The rhodopsin-like GPCRs themselves represent a widespread protein family 
that includes hormone, neurotransmitter and light receptors, all of
which transduce extracellular signals through interaction with guanine
nucleotide-binding (G) proteins. Although their activating ligands vary 
widely in structure and character, the amino acid sequences of the 
receptors are very similar and are believed to adopt a common structural 
framework comprising 7 transmembrane (TM) helices [3-5]. 
 
Chemokines are proteins that have important physiological and patho- 
physiological roles in a wide range of acute and chronic inflammatory
processes [6]. Their sequences are similar and are characterised by a 
4-cysteine motif: the family can be divided according to whether the
first 2 Cys residues are adjacent (the C-C family), or separated by an
intervening residue (the C-x-C family). C-C chemokines are chemoattractant
for monocytes but not for neutrophils. The C-C family includes human
monocyte chemotactic protein-1 (MCP-1), regulated on activation, normal
T cell expressed and secreted (RANTES), and macrophage inflammatory proteins
(MIP-1a and MIP-1b) [6].
 
C-C chemokine receptors are found in monocytes, lymphocytes, basophils and
eosinophils; mRNA is also found in some cell lines [6]. MCP-1 and MIP-1a
induce activation in low nanomolar concentrations and are highly selective
relative to C-x-C receptors. Calcium mobilisation has been demonstrated in
monocytes and in cells expressing the recombinant C-C receptor via an
uncharacterised G protein; pertussis toxin inhibits some of its actions [6].
 
CCCHEMOKINER is a 7-element fingerprint that provides a signature for the 
C-C chemokine receptors. The fingerprint was derived from an initial 
alignment of 11 sequences: the motifs were drawn from conserved sections 
within either loop or TM regions, focusing on those areas of the alignment 
that characterise the C-C chemokine receptors but distinguish them from the 
rest of the rhodopsin-like superfamily - motif 1 lies at the N-terminus, 
leading into TM domain 1; motif 2 spans the first cytoplasmic loop; motif 3 
lies in the first external loop; motif 4 lies in the N-terminal portion of 
TM domain 3; motif 5 spans the second cytoplasmic loop; motif 6 lies in the
N-terminal portion of TM domain 7; and motif 7 lies at the C-terminus. Two 
iterations on OWL29.1 were required to reach convergence, at which point a 
true set comprising 18 sequences was identified. Several partial matches 
were also found, all of which are closely related members of the superfamily
(most of these match motifs 3 and 7).
 
An update on SPTR37_9f identified a true set of 31 sequences, and 48
partial matches.
Summary Information
  31 codes involving  7 elements
0 codes involving 6 elements
4 codes involving 5 elements
7 codes involving 4 elements
4 codes involving 3 elements
33 codes involving 2 elements
Composite Feature Index
731313131313131
60000000
52323433
47374043
32330022
20133110318
1234567
True Positives
CKR1_HUMAN    CKR1_MACMU    CKR1_MOUSE    CKR2_HUMAN    
CKR2_MOUSE CKR3_CERAE CKR3_HUMAN CKR3_MACMU
CKR3_MOUSE CKR4_HUMAN CKR4_MOUSE CKR5_CERAE
CKR5_CERTO CKR5_GORGO CKR5_HUMAN CKR5_MACMU
CKR5_MOUSE CKR5_PANTR CKR5_PAPHA CKR5_RAT
CKRV_MOUSE GPRD_HUMAN GPRD_RAT O00421
O18793 O54814 O55169 O55193
O75307 O77776 O77833
True Positive Partials
Codes involving 5 elements
CKR8_HUMAN CKR8_MOUSE O75303 Q89609
Codes involving 4 elements
CKR6_HUMAN CKR7_HUMAN CKR7_MOUSE O00537
O00590 O08707 O09027
Codes involving 3 elements
GC96_HUMAN O35457 O42444 O70171
Codes involving 2 elements
AG2R_BOVIN AG2R_CANFA AG2R_HUMAN AG2R_MERUN
AG2R_MOUSE AG2R_PIG AG2R_RABIT AG2R_RAT
AG2R_XENLA AG2S_HUMAN AG2S_MOUSE AG2S_RAT
AG2S_XENLA CCR4_BOVIN CCR4_CERTO CCR4_FELCA
CCR4_HUMAN CCR4_MACMU CCR4_MOUSE CCR4_PAPAN
CCR4_RAT GPR5_HUMAN GUSB_BOVIN IL8A_RAT
O42445 O54689 O60835 O77488
PAFR_CAVPO PAFR_HUMAN PAFR_MOUSE PAFR_RAT
VK02_SPVKA
Sequence Titles
CKR1_HUMAN  C-C CHEMOKINE RECEPTOR TYPE 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA RECEPTOR) (MIP-1ALPHA-R) (RANTES-R) (HM145) (LD78 RECEPTOR) - HOMO SAPIENS (HUMAN). 
CKR1_MACMU C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) - Macaca mulatta (Rhesus macaque).
CKR1_MOUSE C-C CHEMOKINE RECEPTOR TYPE 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA RECEPTOR) (MIP-1ALPHA-R) (RANTES-R) - MUS MUSCULUS (MOUSE).
CKR2_HUMAN C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (MONOCYTE CHEMOATTRACTANT PROTEIN 1 RECEPTOR) (MCP-1-R) (CCR2) - HOMO SAPIENS (HUMAN).
CKR2_MOUSE C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR) - MUS MUSCULUS (MOUSE).
CKR3_CERAE C-C CHEMOKINE RECEPTOR TYPE 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) - CERCOPITHECUS AETHIOPS (GREEN MONKEY) (GRIVET).
CKR3_HUMAN C-C CHEMOKINE RECEPTOR TYPE 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (EOSINOPHIL EOTAXIN RECEPTOR) - HOMO SAPIENS (HUMAN).
CKR3_MACMU C-C CHEMOKINE RECEPTOR TYPE 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) - MACACA MULATTA (RHESUS MACAQUE).
CKR3_MOUSE PROBABLE C-C CHEMOKINE RECEPTOR TYPE 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA RECEPTOR-LIKE 2) (MIP- 1 ALPHA RL2) - MUS MUSCULUS (MOUSE).
CKR4_HUMAN C-C CHEMOKINE RECEPTOR TYPE 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) - HOMO SAPIENS (HUMAN).
CKR4_MOUSE C-C CHEMOKINE RECEPTOR TYPE 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) - MUS MUSCULUS (MOUSE).
CKR5_CERAE C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) - CERCOPITHECUS AETHIOPS (GREEN MONKEY) (GRIVET).
CKR5_CERTO C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) - CERCOCEBUS TORQUATUS ATYS (RED-CROWNED MANGABEY) (SOOTY MANGABEY).
CKR5_GORGO C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) - GORILLA GORILLA GORILLA (LOWLAND GORILLA).
CKR5_HUMAN C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (HIV-1 FUSION CO-RECEPTOR) (CHEMR13) - HOMO SAPIENS (HUMAN).
CKR5_MACMU C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) - MACACA MULATTA (RHESUS MACAQUE), MACACA FASCICULARIS (CRAB EATING MACAQUE) (CYNOMOLGUS MONKEY), AND MACACA NEMESTRINA (PIG-TAILED MACAQUE).
CKR5_MOUSE C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (MIP-1 ALPHA RECEPTOR) - MUS MUSCULUS (MOUSE).
CKR5_PANTR C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) - PAN TROGLODYTES (CHIMPANZEE).
CKR5_PAPHA C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) - PAPIO HAMADRYAS (HAMADRYAS BABOON), AND PAPIO ANUBIS (OLIVE BABOON).
CKR5_RAT C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (MIP-1 ALPHA RECEPTOR) - RATTUS NORVEGICUS (RAT).
CKRV_MOUSE C-C CHEMOKINE RECEPTOR (MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA RECEPTOR-LIKE 1) - MUS MUSCULUS (MOUSE).
GPRD_HUMAN PROBABLE G PROTEIN-COUPLED RECEPTOR GPR13 (V28) (BETA CHEMOKINE RECEPTOR-LIKE 1) (CMK-BRL-1) (CMKBLR1) - HOMO SAPIENS (HUMAN).
GPRD_RAT PROBABLE G PROTEIN-COUPLED RECEPTOR GPR13 (RBS11) - RATTUS NORVEGICUS (RAT).
O00421 CCR6 - HOMO SAPIENS (HUMAN).
O18793 CHEMOKINE RECEPTOR - MACACA MULATTA (RHESUS MACAQUE).
O54814 C-C CHEMOKINE RECEPTOR TYPE 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR3) - RATTUS NORVEGICUS (RAT).
O55169 C-C CHEMOKINE RECEPTOR TYPE 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR3) - RATTUS NORVEGICUS (RAT).
O55193 C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) - RATTUS NORVEGICUS (RAT).
O75307 PUTATIVE CHEMOKINE RECEPTOR - HOMO SAPIENS (HUMAN).
O77776 CHEMOKINE RECEPTOR CCR5 - CERCOCEBUS TORQUATUS TORQUATUS.
O77833 CHEMOKINE RECEPTOR CCR5 - CERCOCEBUS TORQUATUS TORQUATUS.

CKR8_HUMAN C-C CHEMOKINE RECEPTOR TYPE 8 (C-C CKR-8) (CC-CKR-8) (CCR-8) (GPR-CY6) (GPRCY6) (CHEMOKINE RECEPTOR-LIKE 1) (CKR-L1) (TER1) (CMKBRL2) (CC- CHEMOKINE RECEPTOR CHEMR1) - Homo sapiens (Human).
CKR8_MOUSE C-C CHEMOKINE RECEPTOR TYPE 8 (C-C CKR-8) (CC-CKR-8) (CCR-8) - Mus musculus (Mouse).
O75303 CC-CHEMOKINE RECEPTOR - HOMO SAPIENS (HUMAN).
Q89609 G PROTEIN-COUPLED RECEPTOR - EQUINE HERPESVIRUS 2.

CKR6_HUMAN C-C CHEMOKINE RECEPTOR TYPE 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (LARC RECEPTOR) (GPR-CY4) (GPRCY4) (CHEMOKINE RECEPTOR-LIKE 3) (CKR-L3) (DRY6) - Homo sapiens (Human).
CKR7_HUMAN C-C CHEMOKINE RECEPTOR TYPE 7 PRECURSOR (C-C CKR-7) (CC-CKR-7) (CCR-7) (MIP-3 BETA RECEPTOR) (EBV-INDUCED G PROTEIN-COUPLED RECEPTOR 1) (EBI1) (BLR2) - HOMO SAPIENS (HUMAN).
CKR7_MOUSE C-C CHEMOKINE RECEPTOR TYPE 7 PRECURSOR (C-C CKR-7) (CC-CKR-7) (CCR-7) (MIP-3 BETA RECEPTOR) (EBV-INDUCED G PROTEIN-COUPLED RECEPTOR 1) (EBI1) - MUS MUSCULUS (MOUSE).
O00537 CHEMOKINE RECEPTOR CCR-9 - HOMO SAPIENS (HUMAN).
O00590 CC-CHEMOKINE RECEPTOR 10 - HOMO SAPIENS (HUMAN).
O08707 CHEMOKINE (C-C) RECEPTOR 9 (BETA-CHEMOKINE RECEPTOR D6) - MUS MUSCULUS (MOUSE).
O09027 CCR10-RELATED RECEPTOR - RATTUS NORVEGICUS (RAT).

GC96_HUMAN PROBABLE G PROTEIN-COUPLED RECEPTOR GPR-9-6 - HOMO SAPIENS (HUMAN).
O35457 PUTATIVE BETA CHEMOKINE RECEPTOR - MUS MUSCULUS (MOUSE).
O42444 INTERLEUKIN-8-LIKE RECEPTOR - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI).
O70171 L-CCR - MUS MUSCULUS (MOUSE).

AG2R_BOVIN TYPE-1 ANGIOTENSIN II RECEPTOR (AT1) - BOS TAURUS (BOVINE).
AG2R_CANFA TYPE-1 ANGIOTENSIN II RECEPTOR (AT1) - CANIS FAMILIARIS (DOG).
AG2R_HUMAN TYPE-1A ANGIOTENSIN II RECEPTOR (AT1A) (AT1AR) - HOMO SAPIENS (HUMAN).
AG2R_MERUN TYPE-1 ANGIOTENSIN II RECEPTOR (AT1) (GKAT1) - MERIONES UNGUICULATUS (MONGOLIAN JIRD).
AG2R_MOUSE TYPE-1A ANGIOTENSIN II RECEPTOR (AT1A) - MUS MUSCULUS (MOUSE).
AG2R_PIG TYPE-1 ANGIOTENSIN II RECEPTOR (AT1) - SUS SCROFA (PIG).
AG2R_RABIT TYPE-1 ANGIOTENSIN II RECEPTOR (AT1) - ORYCTOLAGUS CUNICULUS (RABBIT).
AG2R_RAT TYPE-1A ANGIOTENSIN II RECEPTOR (AT1A) - RATTUS NORVEGICUS (RAT).
AG2R_XENLA TYPE-1-LIKE ANGIOTENSIN II RECEPTOR 1 (AT1) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
AG2S_HUMAN TYPE-1B ANGIOTENSIN II RECEPTOR (AT1B) (AT1BR) - HOMO SAPIENS (HUMAN).
AG2S_MOUSE TYPE-1B ANGIOTENSIN II RECEPTOR (AT1B) (AT3) - MUS MUSCULUS (MOUSE).
AG2S_RAT TYPE-1B ANGIOTENSIN II RECEPTOR (AT1B) (AT3) - RATTUS NORVEGICUS (RAT).
AG2S_XENLA TYPE-1-LIKE ANGIOTENSIN II RECEPTOR 2 (AT1) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
CCR4_BOVIN C-X-C CHEMOKINE RECEPTOR TYPE 4 (CXC-R4) (CXCR-4) (SDF-1 RECEPTOR) (STROMAL CELL-DERIVED FACTOR 1 RECEPTOR) (FUSIN) (LEUKOCYTE-DERIVED SEVEN TRANSMEMBRANE DOMAIN RECEPTOR) (LESTR) (LCR1) - BOS TAURUS (BOVINE).
CCR4_CERTO C-X-C CHEMOKINE RECEPTOR TYPE 4 (CXC-R4) (CXCR-4) (SDF-1 RECEPTOR) (STROMAL CELL-DERIVED FACTOR 1 RECEPTOR) (FUSIN) (LESTR) - CERCOCEBUS TORQUATUS ATYS (RED-CROWNED MANGABEY) (SOOTY MANGABEY).
CCR4_FELCA C-X-C CHEMOKINE RECEPTOR TYPE 4 (CXC-R4) (CXCR-4) (SDF-1 RECEPTOR) (STROMAL CELL-DERIVED FACTOR 1 RECEPTOR) (FUSIN) (LESTR) - FELIS SILVESTRIS CATUS (CAT).
CCR4_HUMAN C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD194 antigen) - Homo sapiens (Human).
CCR4_MACMU C-X-C CHEMOKINE RECEPTOR TYPE 4 (CXC-R4) (CXCR-4) (SDF-1 RECEPTOR) (STROMAL CELL-DERIVED FACTOR 1 RECEPTOR) (FUSIN) (LESTR) - MACACA MULATTA (RHESUS MACAQUE).
CCR4_MOUSE C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (CD194 antigen) - Mus musculus (Mouse).
CCR4_PAPAN C-X-C CHEMOKINE RECEPTOR TYPE 4 (CXC-R4) (CXCR-4) (SDF-1 RECEPTOR) (STROMAL CELL-DERIVED FACTOR 1 RECEPTOR) (FUSIN) - PAPIO ANUBIS (OLIVE BABOON).
CCR4_RAT C-X-C CHEMOKINE RECEPTOR TYPE 4 (CXC-R4) (CXCR-4) (SDF-1 RECEPTOR) (STROMAL CELL-DERIVED FACTOR 1 RECEPTOR) (FUSIN) (LEUKOCYTE-DERIVED SEVEN TRANSMEMBRANE DOMAIN RECEPTOR) (LESTR) - RATTUS NORVEGICUS (RAT).
GPR5_HUMAN PROBABLE G PROTEIN-COUPLED RECEPTOR GPR5 - HOMO SAPIENS (HUMAN).
GUSB_BOVIN POSSIBLE GUSTATORY RECEPTOR TYPE B (PPR1 PROTEIN) - BOS TAURUS (BOVINE).
IL8A_RAT HIGH AFFINITY INTERLEUKIN-8 RECEPTOR A (IL-8R A) (CXCR-1) - RATTUS NORVEGICUS (RAT).
O42445 CXC CHEMOKINE RECEPTOR - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI).
O54689 G PROTEIN-COUPLED RECEPTOR KY411 - MUS MUSCULUS (MOUSE).
O60835 CXCR4 GENE ENCODING RECEPTOR CXCR4 - HOMO SAPIENS (HUMAN).
O77488 CXCR4 RECEPTOR - CERCOPITHECUS AETHIOPS (GREEN MONKEY) (GRIVET).
PAFR_CAVPO PLATELET ACTIVATING FACTOR RECEPTOR (PAF-R) - CAVIA PORCELLUS (GUINEA PIG).
PAFR_HUMAN PLATELET ACTIVATING FACTOR RECEPTOR (PAF-R) - HOMO SAPIENS (HUMAN).
PAFR_MOUSE PLATELET ACTIVATING FACTOR RECEPTOR (PAF-R) - MUS MUSCULUS (MOUSE).
PAFR_RAT PLATELET ACTIVATING FACTOR RECEPTOR (PAF-R) - RATTUS NORVEGICUS (RAT).
VK02_SPVKA G-PROTEIN COUPLED RECEPTOR HOMOLOG K2 - SWINEPOX VIRUS (STRAIN KASZA) (SPV).
Scan History
OWL29_1    2  75   NSINGLE    
SPTR37_9f 2 100 NSINGLE
Initial Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
CHKFDVKQIGAQLLPPLYS CKR2_HUMAN 32 32 -
CQKTAVRAFGAGLLPPLYS CKR1_MOUSE 24 24 -
CEKVRIKELGSWLLPPLYS CKR3_MOUSE 28 28 -
CTKEGIKAFGEVFLPPLYS CKR4_MOUSE 29 29 -
CTKEGIKAFGELFLPPLYS CKR4_HUMAN 29 29 -
CFSINVRAFGITVPTPLYS CKRV_MOUSE 25 25 -
CHKTSVKQIGAWILPPLYS CKRY_MOUSE 45 45 -
CQKINVKQIAARLLPPLYS CKR5_HUMAN 20 20 -
CQKINVKQIAAQLLPPLYS CKR5_MOUSE 22 22 -
CQKVNERAFGAQLLPPLYS CKR1_HUMAN 24 24 -
CEKADTRALMAQFVPPLYS CKR3_HUMAN 24 24 -

Motif 2 width=14
Element Seqn Id St Int Rpt
LINCKKLKCLTDIY CKR2_HUMAN 67 16 -
LIKYRKLQIMTNIY CKR3_MOUSE 63 16 -
LFKYKRLKSMTDVY CKR4_MOUSE 64 16 -
LFKYKRLRSMTDVY CKR4_HUMAN 64 16 -
LIQHKRLRNMTSIY CKRV_MOUSE 60 16 -
LIGCKKLKSMTDIY CKRY_MOUSE 80 16 -
LINCKRLKSMTDIY CKR5_HUMAN 55 16 -
LISCKKLKSVTDIY CKR5_MOUSE 57 16 -
LVQYKRLKNMTSIY CKR1_HUMAN 59 16 -
LIKYRRLRIMTNIY CKR3_HUMAN 59 16 -
LMQHRRLQSMTSIY CKR1_MOUSE 59 16 -

Motif 3 width=11
Element Seqn Id St Int Rpt
FLFTLPFWIDY CKR1_MOUSE 83 10 -
FVLSLPFWGYY CKR4_MOUSE 88 10 -
FLLTLPFWAHY CKRY_MOUSE 104 10 -
FLSTLPFWVDY CKRV_MOUSE 84 10 -
FVFSLPFWGYY CKR4_HUMAN 88 10 -
FLLTVPFWAHY CKR5_HUMAN 79 10 -
FLLTLPFWAHY CKR5_MOUSE 81 10 -
FLFTLPFWIDY CKR1_HUMAN 83 10 -
FLVTLPFWIHY CKR3_HUMAN 83 10 -
FLITLPLWAHS CKR2_HUMAN 91 10 -
FLFTVPFWIHY CKR3_MOUSE 87 10 -

Motif 4 width=14
Element Seqn Id St Int Rpt
TGLYHIGYFGGIFF CKR5_MOUSE 107 15 -
TGLYHIGYFGGIFF CKRY_MOUSE 130 15 -
TGLYFIGFFSGIFF CKR5_HUMAN 105 15 -
SGFYYTGLYSEIFF CKR1_HUMAN 110 16 -
SGFYHTGLYSEIFF CKR3_HUMAN 110 16 -
TGLYHIGYFGGIFF CKR2_HUMAN 117 15 -
SGFYYLGLYSEIFF CKR1_MOUSE 110 16 -
SGFYYLALYSEIFF CKR3_MOUSE 114 16 -
SWMYLVGFYSGIFF CKR4_MOUSE 114 15 -
SWMYLVGFYSGIFF CKR4_HUMAN 114 15 -
SGFYYLGLYSDMFF CKRV_MOUSE 111 16 -

Motif 5 width=18
Element Seqn Id St Int Rpt
HAVFSLRARTLTYGVITS CKR4_HUMAN 141 13 -
HVVFALRARTVTFGIISS CKRV_MOUSE 138 13 -
HAVFALKVRTVNFGVITS CKR5_MOUSE 134 13 -
HAVFALKARTVTFGVVTS CKR5_HUMAN 132 13 -
HAVFALRARTVTFGVITS CKR1_HUMAN 137 13 -
HAVFALKARTVTFGVITS CKRY_MOUSE 157 13 -
HAVFALRARTVTFGVITS CKR3_HUMAN 137 13 -
HAVFALKARTVTFGVVTS CKR2_HUMAN 144 13 -
HAVFALRARTVTLGIITS CKR1_MOUSE 137 13 -
HAVFALRARTVTFATITS CKR3_MOUSE 141 13 -
HAVFSLKARTLTYGVITS CKR4_MOUSE 141 13 -

Motif 6 width=15
Element Seqn Id St Int Rpt
LDYAIQATETLAFVH CKR4_HUMAN 282 123 -
LDQAMQVTETLGMTH CKRY_MOUSE 296 121 -
LDQAMQVTETLGMTH CKR5_HUMAN 275 125 -
LDQAMQATETLGMTH CKR5_MOUSE 277 125 -
LDLAVQVTEVIAYTH CKR1_HUMAN 279 124 -
LDLVMLVTEVIAYSH CKR3_HUMAN 279 124 -
LDQATQVTETLGMTH CKR2_HUMAN 283 121 -
LDLAMQVTEVIAYTH CKR1_MOUSE 279 124 -
LDLAMQVTEVIAYTH CKR3_MOUSE 283 124 -
LDYAIQATETLGFIH CKR4_MOUSE 282 123 -
VDLSLMITEALAYTH CKRV_MOUSE 280 124 -

Motif 7 width=15
Element Seqn Id St Int Rpt
FVGERFRKHLRLFFH CKR3_MOUSE 307 9 -
FLGEKFRKYILQLFK CKR4_HUMAN 306 9 -
FVGKRFRKYLWQLFR CKRV_MOUSE 304 9 -
FVGEKFRNYLLVFFQ CKR5_HUMAN 299 9 -
FVGEKFRRYLSIFFR CKRY_MOUSE 320 9 -
FVGEKFRSYLSVFFR CKR5_MOUSE 301 9 -
FVGERFRKYLRQLFH CKR1_HUMAN 303 9 -
FVGERFRKYLRHFFH CKR3_HUMAN 303 9 -
FVGEKFRSLFHIALG CKR2_HUMAN 307 9 -
FVGERFWKYLRQLFQ CKR1_MOUSE 303 9 -
FLGEKFRKYITQLFR CKR4_MOUSE 306 9 -
Final Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
CQKINVKQIAARLLPPLYS CKR5_CERAE 20 20 -
CQKINVKQIAARLLPPLYS CKR5_CERTO 20 20 -
CQKINVKQIAARLLPPLYS CKR5_HUMAN 20 20 -
CQKINVKQIAARLLPPLYS CKR5_MACMU 20 20 -
CQKINVKQIAARLLPPLYS CKR5_PANTR 20 20 -
CQKINVKQIAARLLPPLYS CKR5_PAPHA 20 20 -
CQKINVKQIAARLLPPLYS O77776 20 20 -
CQKTNVKQIAARLLPPLYS CKR5_GORGO 20 20 -
CQKINVKQIAARLLPPLYS O77833 20 20 -
CHKTSVKQIGAWILPPLYS O55193 45 45 -
CHKTSVKQIGAWILPPLYS CKR2_MOUSE 45 45 -
CQKVNVKQIAAQLLPPLYS CKR5_RAT 22 22 -
CQKINVKQIAAQLLPPLYS CKR5_MOUSE 22 22 -
CHKFDVKQIGAQLLPPLYS O18793 32 32 -
CQKVNERAFGAQLLPPLYS CKR1_HUMAN 24 24 -
CEKADTRALMAQFVPPLYS CKR3_HUMAN 24 24 -
CHKFDVKQIGAQLLPPLYS CKR2_HUMAN 32 32 -
CEKADVGALIAQFVPPLYS CKR3_MACMU 24 24 -
CQKTAVRAFGAGLLPPLYS CKR1_MOUSE 24 24 -
CEKVRIKELGSWLLPPLYS CKR3_MOUSE 28 28 -
CEKADVGALIAQFVPPLYS CKR3_CERAE 24 24 -
CHKVNERAILAQLLPPLYS CKR1_MACMU 24 24 -
CEKVSIRELGSWLLPPLYS O54814 28 28 -
CEKVSIRELGSWLLPPLYS O55169 28 28 -
CTKEGIKAFGEVFLPPLYS CKR4_MOUSE 29 29 -
CTKEGIKAFGELFLPPLYS CKR4_HUMAN 29 29 -
CFSINVRAFGITVPTPLYS CKRV_MOUSE 25 25 -
CYLGDIVAFGTIFLSIFYS GPRD_RAT 22 22 -
CYIGDIVVFGTVFLSIFYS GPRD_HUMAN 21 21 -
CDKYDAQALSAQLVPSLCS O00421 28 28 -
CDKYDAQALSAQLVPSLCS O75307 40 40 -

Motif 2 width=14
Element Seqn Id St Int Rpt
LINCKRLKSMTDIY CKR5_CERAE 55 16 -
LINCKRLKSMTDIY CKR5_CERTO 55 16 -
LINCKRLKSMTDIY CKR5_HUMAN 55 16 -
LINCKRLKSMTDIY CKR5_MACMU 55 16 -
LINCKRLKSMTDIY CKR5_PANTR 55 16 -
LINCKRLKSMTDIY CKR5_PAPHA 55 16 -
LINCKRLKSMTDIY O77776 55 16 -
LINCKRLKSMTDIY CKR5_GORGO 55 16 -
LINCKRLKSMTDIY O77833 55 16 -
LISCKKLKSMTDIY O55193 80 16 -
LIGCKKLKSMTDIY CKR2_MOUSE 80 16 -
LISCKKLKSMTDIY CKR5_RAT 57 16 -
LISCKKLKSVTDIY CKR5_MOUSE 57 16 -
LINCKKLKSLTDIY O18793 67 16 -
LVQYKRLKNMTSIY CKR1_HUMAN 59 16 -
LIKYRRLRIMTNIY CKR3_HUMAN 59 16 -
LINCKKLKCLTDIY CKR2_HUMAN 67 16 -
LIKYRRLRIMTNIY CKR3_MACMU 59 16 -
LMQHRRLQSMTSIY CKR1_MOUSE 59 16 -
LIKYRKLQIMTNIY CKR3_MOUSE 63 16 -
LIKYRRLRIMTNIY CKR3_CERAE 59 16 -
LVQYKRLKNMTNIY CKR1_MACMU 59 16 -
LIKYRKLQIMTNIY O54814 63 16 -
LIKYRKLQIMTNIY O55169 63 16 -
LFKYKRLKSMTDVY CKR4_MOUSE 64 16 -
LFKYKRLRSMTDVY CKR4_HUMAN 64 16 -
LIQHKRLRNMTSIY CKRV_MOUSE 60 16 -
LTNSRKSKSITDIY GPRD_RAT 57 16 -
LTNSKKPKSVTDIY GPRD_HUMAN 56 16 -
LVKYKGLKRVENIY O00421 63 16 -
LVKYKGLKRVENIY O75307 75 16 -

Motif 3 width=11
Element Seqn Id St Int Rpt
FLLTVPFWAHY CKR5_CERAE 79 10 -
FLLTVPFWAHY CKR5_CERTO 79 10 -
FLLTVPFWAHY CKR5_HUMAN 79 10 -
FLLTVPFWAHY CKR5_MACMU 79 10 -
FLLTVPFWAHY CKR5_PANTR 79 10 -
FLLTVPFWAHY CKR5_PAPHA 79 10 -
FLLTVPFWAHY O77776 79 10 -
FLLTVPFWAHY CKR5_GORGO 79 10 -
FLLTVPFWAHY O77833 79 10 -
FLLTLPFWAHY O55193 104 10 -
FLLTLPFWAHY CKR2_MOUSE 104 10 -
FLLTLPFWAHY CKR5_RAT 81 10 -
FLLTLPFWAHY CKR5_MOUSE 81 10 -
FLITLPLWAHS O18793 91 10 -
FLFTLPFWIDY CKR1_HUMAN 83 10 -
FLVTLPFWIHY CKR3_HUMAN 83 10 -
FLITLPLWAHS CKR2_HUMAN 91 10 -
FLFTLPFWIHY CKR3_MACMU 83 10 -
FLFTLPFWIDY CKR1_MOUSE 83 10 -
FLFTVPFWIHY CKR3_MOUSE 87 10 -
FLFTLPFWIHY CKR3_CERAE 83 10 -
FLFTLPFLIYY CKR1_MACMU 83 10 -
FLFTVPFWIHY O54814 87 10 -
FLFTVPFWIHY O55169 87 10 -
FVLSLPFWGYY CKR4_MOUSE 88 10 -
FVFSLPFWGYY CKR4_HUMAN 88 10 -
FLSTLPFWVDY CKRV_MOUSE 84 10 -
FVATLPFWTHY GPRD_RAT 81 10 -
FVATLPFWTHY GPRD_HUMAN 80 10 -
FLLTLPFWAHA O00421 87 10 -
FLLTLPFWAHA O75307 99 10 -

Motif 4 width=14
Element Seqn Id St Int Rpt
TGLYFIGFFSGIFF CKR5_CERAE 105 15 -
TGLYFIGFFSGIFF CKR5_CERTO 105 15 -
TGLYFIGFFSGIFF CKR5_HUMAN 105 15 -
TGLYFIGFFSGIFF CKR5_MACMU 105 15 -
TGLYFIGFFSGIFF CKR5_PANTR 105 15 -
TGLYFIGFFSGIFF CKR5_PAPHA 105 15 -
TGLYFIGFFSGIFF O77776 105 15 -
TGLYFIGFFSGIFF CKR5_GORGO 105 15 -
TGLYFIGFFSGIFF O77833 105 15 -
TGLYHIGYFGGIFF O55193 130 15 -
TGLYHIGYFGGIFF CKR2_MOUSE 130 15 -
TGIYHIGYFGGIFF CKR5_RAT 107 15 -
TGLYHIGYFGGIFF CKR5_MOUSE 107 15 -
TGLYHIGYLGGIFF O18793 117 15 -
SGFYYTGLYSEIFF CKR1_HUMAN 110 16 -
SGFYHTGLYSEIFF CKR3_HUMAN 110 16 -
TGLYHIGYFGGIFF CKR2_HUMAN 117 15 -
SGFYHTGLYSEIFF CKR3_MACMU 110 16 -
SGFYYLGLYSEIFF CKR1_MOUSE 110 16 -
SGFYYLALYSEIFF CKR3_MOUSE 114 16 -
SGFYHTGLYSEIFF CKR3_CERAE 110 16 -
SGFYYTGLYSEIFF CKR1_MACMU 110 16 -
SGLYYLALYSEIFF O54814 114 16 -
SGLYYLALYSEIFF O55169 114 16 -
SWMYLVGFYSGIFF CKR4_MOUSE 114 15 -
SWMYLVGFYSGIFF CKR4_HUMAN 114 15 -
SGFYYLGLYSDMFF CKRV_MOUSE 111 16 -
TAFFFIGFFGGIFF GPRD_RAT 107 15 -
TAFFFIGFFGSIFF GPRD_HUMAN 106 15 -
IGLYFVGLYSETFF O00421 107 9 -
IGLYFVGLYSETFF O75307 119 9 -

Motif 5 width=18
Element Seqn Id St Int Rpt
HAVFALKARTVTFGVVTS CKR5_CERAE 132 13 -
HAVFALKARTVTFGVVTS CKR5_CERTO 132 13 -
HAVFALKARTVTFGVVTS CKR5_HUMAN 132 13 -
HAVFALKARTVTFGVVTS CKR5_MACMU 132 13 -
HAVFALKARTVTFGVVTS CKR5_PANTR 132 13 -
HAVFALKARTVTFGVVTS CKR5_PAPHA 132 13 -
HAVFALKARTVTFGVVTS O77776 132 13 -
HAVFALKARTVTFGVVTS CKR5_GORGO 132 13 -
HAVFALKARTVTFGVVAV O77833 132 13 -
HAVFALKARTVTFGVITS O55193 157 13 -
HAVFALKARTVTFGVITS CKR2_MOUSE 157 13 -
HAVFAIKARTVNFGVITS CKR5_RAT 134 13 -
HAVFALKVRTVNFGVITS CKR5_MOUSE 134 13 -
HAVFALKARTVTFGVVTS O18793 144 13 -
HAVFALRARTVTFGVITS CKR1_HUMAN 137 13 -
HAVFALRARTVTFGVITS CKR3_HUMAN 137 13 -
HAVFALKARTVTFGVVTS CKR2_HUMAN 144 13 -
HAVFALRARTVTFGVITS CKR3_MACMU 137 13 -
HAVFALRARTVTLGIITS CKR1_MOUSE 137 13 -
HAVFALRARTVTFATITS CKR3_MOUSE 141 13 -
HAVFALRARTVTFGVITS CKR3_CERAE 137 13 -
HAVFALRARTVTFGVITS CKR1_MACMU 137 13 -
HAVLALRARTVTFATITS O54814 141 13 -
HAVLALRARTVTFATITS O55169 141 13 -
HAVFSLKARTLTYGVITS CKR4_MOUSE 141 13 -
HAVFSLRARTLTYGVITS CKR4_HUMAN 141 13 -
HVVFALRARTVTFGIISS CKRV_MOUSE 138 13 -
LAANSMNNRTVQHGVTIS GPRD_RAT 134 13 -
LAANSMNNRTVQHGVTIS GPRD_HUMAN 133 13 -
KGNFFSARRRVPCGIITS O00421 135 14 -
KGNFFSARRRVPCGIITS O75307 147 14 -

Motif 6 width=15
Element Seqn Id St Int Rpt
LDQAMQVTETLGMTH CKR5_CERAE 275 125 -
LDQAMQVTETLGMTH CKR5_CERTO 275 125 -
LDQAMQVTETLGMTH CKR5_HUMAN 275 125 -
LDQAMQVTETLGMTH CKR5_MACMU 275 125 -
LDQAMQVTETLGMTH CKR5_PANTR 275 125 -
LDQAMQVTETLGMTH CKR5_PAPHA 275 125 -
LDQAMQVTETLGMTH O77776 275 125 -
LDQAMQVTETLGMTH CKR5_GORGO 275 125 -
LDQAMQVTETLGMTH O77833 267 117 -
LDQAMQVTETLGMTH O55193 296 121 -
LDQAMQVTETLGMTH CKR2_MOUSE 296 121 -
LDQAMQVTETLGMTH CKR5_RAT 277 125 -
LDQAMQATETLGMTH CKR5_MOUSE 277 125 -
LDQATQVTETLGMTH O18793 283 121 -
LDLAVQVTEVIAYTH CKR1_HUMAN 279 124 -
LDLVMLVTEVIAYSH CKR3_HUMAN 279 124 -
LDQATQVTETLGMTH CKR2_HUMAN 283 121 -
LDLFVLATEVIAYSH CKR3_MACMU 279 124 -
LDLAMQVTEVIAYTH CKR1_MOUSE 279 124 -
LDLAMQVTEVIAYTH CKR3_MOUSE 283 124 -
VDLVVLVTEVIAYSH CKR3_CERAE 279 124 -
LDLAMEVTEVIANMH CKR1_MACMU 279 124 -
LDLAMQVTEVITHTH O54814 283 124 -
LDLAMQVTEVITHTH O55169 283 124 -
LDYAIQATETLGFIH CKR4_MOUSE 282 123 -
LDYAIQATETLAFVH CKR4_HUMAN 282 123 -
VDLSLMITEALAYTH CKRV_MOUSE 280 124 -
LRWALSVTETVAFSH GPRD_RAT 272 120 -
LRLALSVTETVAFSH GPRD_HUMAN 271 120 -
LDKSVHITKLIATTH O00421 278 125 -
LDKSVHITKLIATTH O75307 290 125 -

Motif 7 width=15
Element Seqn Id St Int Rpt
FVGEKFRNYLLVFFQ CKR5_CERAE 299 9 -
FVGEKFRNYLLVFFQ CKR5_CERTO 299 9 -
FVGEKFRNYLLVFFQ CKR5_HUMAN 299 9 -
FVGEKFRNYLLVFFQ CKR5_MACMU 299 9 -
FVGEKFRNYLLVFFQ CKR5_PANTR 299 9 -
FVGEKFRNYLLVFFQ CKR5_PAPHA 299 9 -
FVGEKFRNYLLVFFQ O77776 299 9 -
FVGEKFRNYLLVFFQ CKR5_GORGO 299 9 -
FVGEKFRNYLLVFFQ O77833 291 9 -
FVGEKFRRYLSIFFR O55193 320 9 -
FVGEKFRRYLSIFFR CKR2_MOUSE 320 9 -
FVGEKFRNYLSVFFR CKR5_RAT 301 9 -
FVGEKFRSYLSVFFR CKR5_MOUSE 301 9 -
FVGEKFRRYLSMFFR O18793 307 9 -
FVGERFRKYLRQLFH CKR1_HUMAN 303 9 -
FVGERFRKYLRHFFH CKR3_HUMAN 303 9 -
FVGEKFRSLFHIALG CKR2_HUMAN 307 9 -
FVGERFRKYLRHFFH CKR3_MACMU 303 9 -
FVGERFWKYLRQLFQ CKR1_MOUSE 303 9 -
FVGERFRKHLRLFFH CKR3_MOUSE 307 9 -
FVGERFRKYLRHFFH CKR3_CERAE 303 9 -
FAGERFRKYLRQLFH CKR1_MACMU 303 9 -
FVGERFRKHLRLFFH O54814 307 9 -
FVGERFRKHLRLFFH O55169 307 9 -
FLGEKFRKYITQLFR CKR4_MOUSE 306 9 -
FLGEKFRKYILQLFK CKR4_HUMAN 306 9 -
FVGKRFRKYLWQLFR CKRV_MOUSE 304 9 -
FAGEKFRRYLRHLYN GPRD_RAT 296 9 -
FAGEKFRRYLYHLYG GPRD_HUMAN 295 9 -
FLDGTFSKYLCRCFH O00421 302 9 -
FLDGTFSKYLCRCFH O75307 314 9 -