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PR00645

Identifier
CXCCHMKINER4  [View Relations]  [View Alignment]  
Accession
PR00645
No. of Motifs
9
Creation Date
09-DEC-1996  (UPDATE 10-JUN-1999)
Title
C-X-C chemokine receptor type 4 signature
Database References
PRINTS; PR90007 7TM; PR90006 GPCRCLAN; PR00237 GPCRRHODOPSN

INTERPRO; IPR001277
Literature References
1. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994).
 
2. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
G protein-coupled receptor fingerprints.
7TM, VOLUME 2, EDS. G.VRIEND AND B.BYWATER (1993).
 
3. BIRNBAUMER, L.
G proteins in signal transduction.
ANNU.REV.PHARMACOL.TOXICOL. 30 675-705 (1990).
 
4. CASEY, P.J. AND GILMAN, A.G.
G protein involvement in receptor-effector coupling.
J.BIOL.CHEM. 263(6) 2577-2580 (1988).
 
5. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Design of a discriminating fingerprint for G protein-coupled receptors.
PROTEIN ENG. 6(2) 167-176 (1993).
 
6. WATSON, S. AND ARKINSTALL,
Orphan receptors.
IN THE G PROTEIN-LINKED RECEPTOR FACTSBOOK, ACADEMIC PRESS, pp223-230.
 
7. RIMLAND, J., XIN, W., SWEETNAM, P., SAIJOH, K., NESTLER, E.J. AND
DUMAN, R.S. 
Sequence and expression of a neuropeptide Y receptor cDNA.
MOL.PHARMACOL. 40 869-875 (1991).
 
8. JAZIN, E.E., YOO, H., BLOMQVIST, A.G., YEE, F., WENG, G., WALKER, M.W.,  
SALON, J., LARHAMMAR, D. AND WAHLESTEDT, C. 
A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human
homologue, confers neither NPY binding sites nor NPY responsiveness on
transfected cells. 
REGUL.PEPT. 47 247-258 (1993).

Documentation
G protein-coupled receptors (GPCRs) constitute a vast protein family that 
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the 
sequence level, on the basis of which they can be separated into distinct 
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship, 
but between which there is no statistically significant similarity in 
sequence [1]. The currently known clan members include the rhodopsin-like 
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
 
The rhodopsin-like GPCRs themselves represent a widespread protein family 
that includes hormone, neurotransmitter and light receptors, all of
which transduce extracellular signals through interaction with guanine
nucleotide-binding (G) proteins. Although their activating ligands vary 
widely in structure and character, the amino acid sequences of the 
receptors are very similar and are believed to adopt a common structural 
framework comprising 7 transmembrane (TM) helices [3-5]. 
 
Several 7TM receptors have been cloned but their endogenous ligands are
unknown; these have been termed orphan receptors. LCR1 was isolated from
a locus coeruleus library and its mRNA is also present in cerebellum, pons,
dorsal raphe, thalamus and substantia nigra [6,7]. It was originally thought
to encode a neuropeptide Y receptor (NPY3-R) [7], but this has been shown to
be incorrect [8], and it is now thought to be a type 4 C-X-C chemokine 
receptor.

CXCCHMKINER4 is a 9-element fingerprint that provides a signature for 
the type 4 C-X-C chemokine receptors. The fingerprint was derived from 
an initial alignment of 6 sequences: the motifs were drawn from conserved 
sections within either loop or N- and C-terminal regions, focusing on 
those areas of the alignment that characterise the type 4 C-X-C chemokine 
receptors but distinguish them from the rest of the rhodopsin-like super-
family - motifs 1 and 2 span the N-terminus, motif 2 leading into the 
N-terminal portion of TM domain 1; motif 3 spans the first cytoplasmic 
loop; motif 4 spans the first external loop; motif 5 lies in the second 
cytoplasmic loop; motif 6 lies in the second external loop; motif 7 spans
the third cytoplasmic loop; motif 8 spans the third external loop; and 
motif 9 resides at the C-terminus. A single iteration on OWL29.0 was 
required to reach convergence, no further sequences being identified beyond
the starting set. Several partial matches were also found: OAU38942 and 
MMLCR11 are N-terminal fragments lacking the last 3 and the last 4 motifs 
respectively; and the remaining matches are closely related members of the
rhodopsin superfamily, largely belonging to the chemokine and interleukin-8
receptor families.
  
An update on SPTR37_9f identified a true set of 12 sequences, and 19
Summary Information
  12 codes involving  9 elements
0 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
2 codes involving 4 elements
0 codes involving 3 elements
17 codes involving 2 elements
Composite Feature Index
9121212121212121212
8000000000
7000000000
6000000000
5000000000
4022220000
3000000000
204116130000
123456789
True Positives
CCR4_BOVIN    CCR4_CERTO    CCR4_FELCA    CCR4_HUMAN    
CCR4_MACFA CCR4_MACMU CCR4_MOUSE CCR4_PAPAN
CCR4_RAT O60835 O77488 Q62973
True Positive Partials
Codes involving 4 elements
O42445 O93247
Codes involving 2 elements
CKR2_MOUSE CKR4_HUMAN CKR4_MOUSE CKR5_CERAE
CKR5_CERTO CKR5_GORGO CKR5_MACMU CKR5_PANTR
CKR5_PAPHA CKR5_RAT CKR7_HUMAN IL8A_GORGO
IL8A_HUMAN IL8A_PANTR O00537 O00590
O09027
Sequence Titles
CCR4_BOVIN  C-X-C CHEMOKINE RECEPTOR TYPE 4 (CXC-R4) (CXCR-4) (SDF-1 RECEPTOR) (STROMAL CELL-DERIVED FACTOR 1 RECEPTOR) (FUSIN) (LEUKOCYTE-DERIVED SEVEN TRANSMEMBRANE DOMAIN RECEPTOR) (LESTR) (LCR1) - BOS TAURUS (BOVINE). 
CCR4_CERTO C-X-C CHEMOKINE RECEPTOR TYPE 4 (CXC-R4) (CXCR-4) (SDF-1 RECEPTOR) (STROMAL CELL-DERIVED FACTOR 1 RECEPTOR) (FUSIN) (LESTR) - CERCOCEBUS TORQUATUS ATYS (RED-CROWNED MANGABEY) (SOOTY MANGABEY).
CCR4_FELCA C-X-C CHEMOKINE RECEPTOR TYPE 4 (CXC-R4) (CXCR-4) (SDF-1 RECEPTOR) (STROMAL CELL-DERIVED FACTOR 1 RECEPTOR) (FUSIN) (LESTR) - FELIS SILVESTRIS CATUS (CAT).
CCR4_HUMAN C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD194 antigen) - Homo sapiens (Human).
CCR4_MACFA C-X-C CHEMOKINE RECEPTOR TYPE 4 (CXC-R4) (CXCR-4) (SDF-1 RECEPTOR) (STROMAL CELL-DERIVED FACTOR 1 RECEPTOR) (FUSIN) (LESTR) - MACACA FASCICULARIS (CRAB EATING MACAQUE) (CYNOMOLGUS MONKEY).
CCR4_MACMU C-X-C CHEMOKINE RECEPTOR TYPE 4 (CXC-R4) (CXCR-4) (SDF-1 RECEPTOR) (STROMAL CELL-DERIVED FACTOR 1 RECEPTOR) (FUSIN) (LESTR) - MACACA MULATTA (RHESUS MACAQUE).
CCR4_MOUSE C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (CD194 antigen) - Mus musculus (Mouse).
CCR4_PAPAN C-X-C CHEMOKINE RECEPTOR TYPE 4 (CXC-R4) (CXCR-4) (SDF-1 RECEPTOR) (STROMAL CELL-DERIVED FACTOR 1 RECEPTOR) (FUSIN) - PAPIO ANUBIS (OLIVE BABOON).
CCR4_RAT C-X-C CHEMOKINE RECEPTOR TYPE 4 (CXC-R4) (CXCR-4) (SDF-1 RECEPTOR) (STROMAL CELL-DERIVED FACTOR 1 RECEPTOR) (FUSIN) (LEUKOCYTE-DERIVED SEVEN TRANSMEMBRANE DOMAIN RECEPTOR) (LESTR) - RATTUS NORVEGICUS (RAT).
O60835 CXCR4 GENE ENCODING RECEPTOR CXCR4 - HOMO SAPIENS (HUMAN).
O77488 CXCR4 RECEPTOR - CERCOPITHECUS AETHIOPS (GREEN MONKEY) (GRIVET).
Q62973 CHEMOKINE RECEPTOR LCR1 - RATTUS NORVEGICUS (RAT).

O42445 CXC CHEMOKINE RECEPTOR - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI).
O93247 CXCR4 - CYPRINUS CARPIO (COMMON CARP).

CKR2_MOUSE C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR) - MUS MUSCULUS (MOUSE).
CKR4_HUMAN C-C CHEMOKINE RECEPTOR TYPE 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) - HOMO SAPIENS (HUMAN).
CKR4_MOUSE C-C CHEMOKINE RECEPTOR TYPE 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) - MUS MUSCULUS (MOUSE).
CKR5_CERAE C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) - CERCOPITHECUS AETHIOPS (GREEN MONKEY) (GRIVET).
CKR5_CERTO C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) - CERCOCEBUS TORQUATUS ATYS (RED-CROWNED MANGABEY) (SOOTY MANGABEY).
CKR5_GORGO C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) - GORILLA GORILLA GORILLA (LOWLAND GORILLA).
CKR5_MACMU C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) - MACACA MULATTA (RHESUS MACAQUE), MACACA FASCICULARIS (CRAB EATING MACAQUE) (CYNOMOLGUS MONKEY), AND MACACA NEMESTRINA (PIG-TAILED MACAQUE).
CKR5_PANTR C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) - PAN TROGLODYTES (CHIMPANZEE).
CKR5_PAPHA C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) - PAPIO HAMADRYAS (HAMADRYAS BABOON), AND PAPIO ANUBIS (OLIVE BABOON).
CKR5_RAT C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (MIP-1 ALPHA RECEPTOR) - RATTUS NORVEGICUS (RAT).
CKR7_HUMAN C-C CHEMOKINE RECEPTOR TYPE 7 PRECURSOR (C-C CKR-7) (CC-CKR-7) (CCR-7) (MIP-3 BETA RECEPTOR) (EBV-INDUCED G PROTEIN-COUPLED RECEPTOR 1) (EBI1) (BLR2) - HOMO SAPIENS (HUMAN).
IL8A_GORGO HIGH AFFINITY INTERLEUKIN-8 RECEPTOR A (IL-8R A) (IL-8 RECEPTOR TYPE 1) (CXCR-1) (CDW128) - GORILLA GORILLA GORILLA (LOWLAND GORILLA), AND PONGO PYGMAEUS (ORANGUTAN).
IL8A_HUMAN HIGH AFFINITY INTERLEUKIN-8 RECEPTOR A (IL-8R A) (IL-8 RECEPTOR TYPE 1) (CXCR-1) (CDW128) - HOMO SAPIENS (HUMAN).
IL8A_PANTR HIGH AFFINITY INTERLEUKIN-8 RECEPTOR A (IL-8R A) (IL-8 RECEPTOR TYPE 1) (CXCR-1) (CDW128) - PAN TROGLODYTES (CHIMPANZEE).
O00537 CHEMOKINE RECEPTOR CCR-9 - HOMO SAPIENS (HUMAN).
O00590 CC-CHEMOKINE RECEPTOR 10 - HOMO SAPIENS (HUMAN).
O09027 CCR10-RELATED RECEPTOR - RATTUS NORVEGICUS (RAT).
Scan History
OWL29_0    1  50   NSINGLE    
SPTR37_9f 2 58 NSINGLE
Initial Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
GSGDYDSNKEPCFRDEN MMLCR12 17 17 -
GSGDYDSNKEPCFRDEN MMU59760 19 19 -
GSGDYDSNKEPCFRDEN RNU54791 14 14 -
GSGDYDSMKEPCFREEN LCR1_BOVIN 18 18 -
GSGDYDSMKEPCFREEN LCR1_HUMAN 17 17 -
GSGDYDSIKEPCFREEN D86579 17 17 -

Motif 2 width=16
Element Seqn Id St Int Rpt
NVHFNRIFLPTIYFII MMLCR12 33 -1 -
NVHFNRIFLPTIYFII MMU59760 35 -1 -
NENFNRIFLPTIYFII RNU54791 30 -1 -
NAHFNRIFLPTVYSII LCR1_BOVIN 34 -1 -
NANFNKIFLPTIYSII LCR1_HUMAN 33 -1 -
NAHFNRIFLPTIYSII D86579 33 -1 -

Motif 3 width=17
Element Seqn Id St Int Rpt
MGYQKKLRSMTDKYRLH MMLCR12 63 14 -
MGYQKKLRSMTDKYRLH MMU59760 65 14 -
MGYQKKLRSMTDKYRLH RNU54791 60 14 -
MGYQKKLRSMTDKYRLH LCR1_BOVIN 64 14 -
MGYQKKLRSMTDKYRLH LCR1_HUMAN 63 14 -
MGYQKKLRSMTDKYRLH D86579 63 14 -

Motif 4 width=16
Element Seqn Id St Int Rpt
ADWYFGKFLCKAVHII MMLCR12 100 20 -
ADWYFGKFLCKAVHII MMU59760 102 20 -
ADWYFGKFLCKAVHII RNU54791 95 18 -
ANWYFGKFLCKAVHVI LCR1_BOVIN 101 20 -
ANWYFGNFLCKAVHVI LCR1_HUMAN 100 20 -
ANWYFGNFLCKAVHVI D86579 100 20 -

Motif 5 width=12
Element Seqn Id St Int Rpt
LAIVHATNSQRP MMLCR12 136 20 -
LAIVHATNSQRP MMU59760 138 20 -
LAIVHATNSQSA RNU54791 131 20 -
LAIVHATNSQKP LCR1_BOVIN 137 20 -
LAIVHATNSQRP LCR1_HUMAN 136 20 -
LAIVHATNSQRP D86579 136 20 -

Motif 6 width=21
Element Seqn Id St Int Rpt
DDRYICDRLYPDSLWMVVFQF MMLCR12 186 38 -
DDRYICDRLYPDSLWMVVFQF MMU59760 188 38 -
DGRYICDRLYPDSLWMVVFQF RNU54791 161 18 -
DERYICDRFYPSDLWLVVFQF LCR1_BOVIN 182 33 -
DDRYICDRFYPNDLWVVVFQF LCR1_HUMAN 181 33 -
DDRYICDRFYPNDLWVVVFQF D86579 181 33 -

Motif 7 width=18
Element Seqn Id St Int Rpt
SKLSHSKGHQKRKALKTT MMLCR12 229 22 -
SKLSHSKGHQKRKALKTT MMU59760 231 22 -
SKLSHSKGHQKRKALKTT RNU54791 204 22 -
SKLSHSKGYQKRKALKTT LCR1_BOVIN 225 22 -
SKLSHSKGHQKRKALKTT LCR1_HUMAN 224 22 -
SKLSHSKGHQKRKALKTT D86579 224 22 -

Motif 8 width=15
Element Seqn Id St Int Rpt
IKQGCDFESIVHKWI MMLCR12 275 28 -
IKQGCDFESIVHKWI MMU59760 277 28 -
IKQGCEFESVVHKWI RNU54791 250 28 -
IQQGCEFESTVHKWI LCR1_BOVIN 271 28 -
IKQGCEFENTVHKWI LCR1_HUMAN 270 28 -
IKQGCEFENTVHKWI D86579 270 28 -

Motif 9 width=19
Element Seqn Id St Int Rpt
RGSSLKILSKGKRGGHSSV MMLCR12 327 37 -
RGSSLKILSKGKRGGHSSV MMU59760 329 37 -
RGSSLKILSKGKRGGHSSV RNU54791 302 37 -
RGSSLKILSKGKRGGHSSV LCR1_BOVIN 323 37 -
RGSSLKILSKGKRGGHSSV LCR1_HUMAN 322 37 -
RGSSLKILSKGKRGGHSSV D86579 322 37 -
Final Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
GSGDYDSIKEPCFREEN CCR4_MACFA 17 17 -
GSGDYDSIKEPCFREEN O77488 17 17 -
GSGDYDSIKEPCFREEN CCR4_PAPAN 17 17 -
GSGDYDSIKEPCFREEN CCR4_MACMU 17 17 -
GSGDYDSMKEPCFREEN CCR4_HUMAN 17 17 -
GSGDYDSMKEPCFREEN O60835 25 25 -
GSGDYDSIKEPCFREKN CCR4_CERTO 17 17 -
GSGDYDSMKEPCFREEN CCR4_FELCA 18 18 -
GSGDYDSMKEPCFREEN CCR4_BOVIN 18 18 -
GSGDYDSNKEPCFRDEN CCR4_MOUSE 19 19 -
GSGDYDSNKEPCFRDEN CCR4_RAT 14 14 -
GSGDYDSNKEPCFRDEN Q62973 14 14 -

Motif 2 width=16
Element Seqn Id St Int Rpt
NAHFNRIFLPTIYSII CCR4_MACFA 33 -1 -
NAHFNRIFLPTIYSII O77488 33 -1 -
NAHFNRIFLPTIYSII CCR4_PAPAN 33 -1 -
NAHFNRIFLPTIYSII CCR4_MACMU 33 -1 -
NANFNKIFLPTIYSII CCR4_HUMAN 33 -1 -
NANFNKIFLPTIYSII O60835 41 -1 -
NAHFNRIFLPTIYSII CCR4_CERTO 33 -1 -
NAHFNRIFLPTVYSII CCR4_FELCA 34 -1 -
NAHFNRIFLPTVYSII CCR4_BOVIN 34 -1 -
NVHFNRIFLPTIYFII CCR4_MOUSE 35 -1 -
NENFNRIFLPTIYFII CCR4_RAT 30 -1 -
NENFNRIFLPTIYFII Q62973 30 -1 -

Motif 3 width=17
Element Seqn Id St Int Rpt
MGYQKKLRSMTDKYRLH CCR4_MACFA 63 14 -
MGYQKKLRSMTDKYRLH O77488 63 14 -
MGYQKKLRSMTDKYRLH CCR4_PAPAN 63 14 -
MGYQKKLRSMTDKYRLH CCR4_MACMU 63 14 -
MGYQKKLRSMTDKYRLH CCR4_HUMAN 63 14 -
MGYQKKLRSMTDKYRLH O60835 71 14 -
MGYQKKLRSMTDKYRLH CCR4_CERTO 63 14 -
MGYQKKLRSMTDKYRLH CCR4_FELCA 64 14 -
MGYQKKLRSMTDKYRLH CCR4_BOVIN 64 14 -
MGYQKKLRSMTDKYRLH CCR4_MOUSE 65 14 -
MGYQKKLRSMTDKYRLH CCR4_RAT 60 14 -
MGYQKKLRSMTDKYRLH Q62973 60 14 -

Motif 4 width=16
Element Seqn Id St Int Rpt
ANWYFGNFLCKAVHVI CCR4_MACFA 100 20 -
ANWYFGNFLCKAVHVI O77488 100 20 -
ANWYFGNFLCKAVHVI CCR4_PAPAN 100 20 -
ANWYFGNFLCKAVHVI CCR4_MACMU 100 20 -
ANWYFGNFLCKAVHVI CCR4_HUMAN 100 20 -
ANWYFGNFLCKAVHVI O60835 108 20 -
ANWYFGNFLCKAVHVI CCR4_CERTO 100 20 -
ANWYFGKFLCKAVHVI CCR4_FELCA 101 20 -
ANWYFGKFLCKAVHVI CCR4_BOVIN 101 20 -
ADWYFGKFLCKAVHII CCR4_MOUSE 102 20 -
ADWYFGKFLCKAVHII CCR4_RAT 97 20 -
ADWYFGKFLCKAVHII Q62973 95 18 -

Motif 5 width=12
Element Seqn Id St Int Rpt
LAIVHATNSQRP CCR4_MACFA 136 20 -
LAIVHATNSQRP O77488 136 20 -
LAIVHATNSQRP CCR4_PAPAN 136 20 -
LAIVHATNSQKP CCR4_MACMU 136 20 -
LAIVHATNSQRP CCR4_HUMAN 136 20 -
LAIVHATNSQRP O60835 144 20 -
LAIVHATNSQKP CCR4_CERTO 136 20 -
LAIVHATNSQRP CCR4_FELCA 137 20 -
LAIVHATNSQKP CCR4_BOVIN 137 20 -
LAIVHATNSQRP CCR4_MOUSE 138 20 -
LAIVHATNSQSA CCR4_RAT 133 20 -
LAIVHATNSQSA Q62973 131 20 -

Motif 6 width=21
Element Seqn Id St Int Rpt
DDRYICDRFYPNDLWVVVFQF CCR4_MACFA 181 33 -
DDRYICDRFYPNDLWVVVFQF O77488 181 33 -
DDRYICDRFYPNDLWVVVFQF CCR4_PAPAN 181 33 -
DDRYICDRFYPNDLWVVVFQF CCR4_MACMU 181 33 -
DDRYICDRFYPNDLWVVVFQF CCR4_HUMAN 181 33 -
DDRYICDRFYPNDLWVVVFQF O60835 189 33 -
DDRFICDRFYPNDLWVVVFQF CCR4_CERTO 181 33 -
DGRYICDRFYPSDSWLVVFQF CCR4_FELCA 182 33 -
DERYICDRFYPSDLWLVVFQF CCR4_BOVIN 182 33 -
DDRYICDRLYPDSLWMVVFQF CCR4_MOUSE 188 38 -
DGRYICDRLYPDSLWMVVFQF CCR4_RAT 178 33 -
DGRYICDRLYPDSLWMVVFQF Q62973 161 18 -

Motif 7 width=18
Element Seqn Id St Int Rpt
SKLSHSKGHQKRKALKTT CCR4_MACFA 224 22 -
SKLSHSKGHQKRKALKTT O77488 224 22 -
SKLSHSKGHQKRKALKTT CCR4_PAPAN 224 22 -
SKLSHSKGHQKRKALKTT CCR4_MACMU 224 22 -
SKLSHSKGHQKRKALKTT CCR4_HUMAN 224 22 -
SKLSHSKGHQKRKALKTT O60835 232 22 -
SKLSHSKGHQKRKALKTT CCR4_CERTO 224 22 -
SKLSHSKGYQKRKALKTT CCR4_FELCA 225 22 -
SKLSHSKGYQKRKALKTT CCR4_BOVIN 225 22 -
SKLSHSKGHQKRKALKTT CCR4_MOUSE 231 22 -
SKLSHSKGHQKRKALKTT CCR4_RAT 221 22 -
SKLSHSKGHQKRKALKTT Q62973 204 22 -

Motif 8 width=15
Element Seqn Id St Int Rpt
IKQGCEFENTVHKWI CCR4_MACFA 270 28 -
IKQGCEFENTVHKWI O77488 270 28 -
IKQGCEFENTVHKWI CCR4_PAPAN 270 28 -
IKQGCEFENTVHKWI CCR4_MACMU 270 28 -
IKQGCEFENTVHKWI CCR4_HUMAN 270 28 -
IKQGCEFENTVHKWI O60835 278 28 -
IKQGCEFENTVHKWI CCR4_CERTO 270 28 -
IKQGCEFESTVHKWI CCR4_FELCA 271 28 -
IQQGCEFESTVHKWI CCR4_BOVIN 271 28 -
IKQGCDFESIVHKWI CCR4_MOUSE 277 28 -
IKQGCEFESVVHKWI CCR4_RAT 267 28 -
IKQGCEFESVVHKWI Q62973 250 28 -

Motif 9 width=19
Element Seqn Id St Int Rpt
RGSSLKILSKGKRGGHSSV CCR4_MACFA 322 37 -
RGSSLKILSKGKRGGHSSV O77488 322 37 -
RGSSLKILSKGKRGGHSSV CCR4_PAPAN 322 37 -
RGSSLKILSKGKRGGHSSV CCR4_MACMU 322 37 -
RGSSLKILSKGKRGGHSSV CCR4_HUMAN 322 37 -
RGSSLKILSKGKRGGHSSV O60835 330 37 -
RGSSLKILSKGKRGGHSSV CCR4_CERTO 322 37 -
RGSSLKILSKGKRGGHSSV CCR4_FELCA 323 37 -
RGSSLKILSKGKRGGHSSV CCR4_BOVIN 323 37 -
RGSSLKILSKGKRGGHSSV CCR4_MOUSE 329 37 -
RGSSLKILSKGKRGGHSSV CCR4_RAT 319 37 -
RGSSLKILSKGKRGGHSSV Q62973 302 37 -