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PR00627

Identifier
GTPRANTC4  [View Relations]  [View Alignment]  
Accession
PR00627
No. of Motifs
5
Creation Date
07-DEC-1996  (UPDATE 07-JUN-1999)
Title
GTP-binding nuclear protein Ran/Tc4 family signature
Database References

PROSITE; PS01115 RAN
INTERPRO; IPR002041
Literature References
1. SCHEFFZEK, K., KLEBE, C., FRITZ-WOLF, K., KABSCH, W. AND WITTINGHOFER, A.
Crystal structure of the nuclear ras-related protein RAN in its GDP-
bound form. 
NATURE 374 378-381 (1995).
 
2. RUSH, M.G., DRIVAS, G. AND D'EUSTACHIO, P.
The small nuclear GTPase ran - how much does it run.
BIOESSAYS 18 103-112 (1996).
 
3. VALENCIA, A., CHARDIN, P., WITTINGHOFER, A. AND SANDER, C.
The RAS protein family - evolutionary tree and role of conserved
amino-acids.
BIOCHEMISTRY 30 4637-4648 (1991). 

Documentation
The small nuclear protein Ran (or TC4) binds and hydrolyses GTP, and has
been implicated in a large number of processes: e.g., nucleocytoplasmic
transport; RNA synthesis, processing and export; and cell cycle check-
point control [1,2].
 
Ran is a distant relative of the Ras superfamily of small GTP-binding
proteins [3]. It principally differs from the Ras family in bearing an
acidic C-terminus, rather than having C-terminal cysteine residues, which
in Ras are subject to prenylation. Nevertheless, in common with Ras
proteins, it requires a specific guanine nucleotide exchange factor and a
specific GTPase activating protein to stimulate overall GTPase activity.
 
GTPRANTC4 is a 5-element fingerprint that provides a signature for the
GTP-binding nuclear protein Ran/Tc4 family. The fingerprint was derived
from an initial alignment of 18 sequences: the motifs were drawn from
short conserved regions spanning virtually the full alignment length, motif
2 encompassing part of the GTP-binding B motif (cf. PROSITE pattern RAN
(PS01115)). Two iterations on OWL29.0 were required to reach convergence,
at which point a true set comprising 25 sequences was identified. Two
partial matches were also found, both of which are fragments: CEU66216
lacks the first motif, and ATTS1902 lacks motifs 4 and 5.
 
An update on SPTR37_9f identified a true set of 26 sequences.
Summary Information
26 codes involving  5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
52626262626
400000
300000
200000
12345
True Positives
GSP1_YEAST    GSP2_YEAST    O04148        O04664        
O17915 O22495 RAN1_ARATH RAN1_LYCES
RAN2_ARATH RAN2_LYCES RANA_TOBAC RANB_TOBAC
RANT_MOUSE RAN_BRARE RAN_BRUMA RAN_CHICK
RAN_DICDI RAN_GIALA RAN_HUMAN RAN_MOUSE
RAN_ONCVO RAN_PLAFA RAN_TETPY RAN_TETTH
RAN_VICFA SPI1_SCHPO
Sequence Titles
GSP1_YEAST  GTP-BINDING NUCLEAR PROTEIN GSP1/CNR1 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). 
GSP2_YEAST GTP-BINDING NUCLEAR PROTEIN GSP2/CNR2 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
O04148 ATRAN3 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O04664 SMALL RAS-LIKE GTP-BINDING PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O17915 K01G5.4 PROTEIN - CAENORHABDITIS ELEGANS.
O22495 SALT STRESS INDUCIBLE SMALL GTP BINDING PROTEIN RAN1 HOMOLOG - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
RAN1_ARATH GTP-BINDING NUCLEAR PROTEIN RAN-1 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
RAN1_LYCES GTP-BINDING NUCLEAR PROTEIN RAN1 - LYCOPERSICON ESCULENTUM (TOMATO).
RAN2_ARATH GTP-BINDING NUCLEAR PROTEIN RAN-2 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
RAN2_LYCES GTP-BINDING NUCLEAR PROTEIN RAN2 - LYCOPERSICON ESCULENTUM (TOMATO).
RANA_TOBAC GTP-BINDING NUCLEAR PROTEIN RAN-A1 - NICOTIANA TABACUM (COMMON TOBACCO).
RANB_TOBAC GTP-BINDING NUCLEAR PROTEIN RAN-B1 - NICOTIANA TABACUM (COMMON TOBACCO).
RANT_MOUSE GTP-BINDING NUCLEAR PROTEIN RAN, TESTIS-SPECIFIC ISOFORM - MUS MUSCULUS (MOUSE).
RAN_BRARE GTP-BINDING NUCLEAR PROTEIN RAN - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
RAN_BRUMA GTP-BINDING NUCLEAR PROTEIN RAN/TC4 - BRUGIA MALAYI.
RAN_CHICK GTP-BINDING NUCLEAR PROTEIN RAN (TC4) - GALLUS GALLUS (CHICKEN).
RAN_DICDI GTP-BINDING NUCLEAR PROTEIN RAN/TC4 - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).
RAN_GIALA GTP-BINDING NUCLEAR PROTEIN RAN/TC4 - GIARDIA LAMBLIA (GIARDIA INTESTINALIS).
RAN_HUMAN GTP-BINDING NUCLEAR PROTEIN RAN (TC4) - HOMO SAPIENS (HUMAN).
RAN_MOUSE GTP-BINDING NUCLEAR PROTEIN RAN (TC4) - MUS MUSCULUS (MOUSE), AND CANIS FAMILIARIS (DOG).
RAN_ONCVO GTP-BINDING NUCLEAR PROTEIN RAN/TC4 - ONCHOCERCA VOLVULUS.
RAN_PLAFA GTP-BINDING NUCLEAR PROTEIN RAN/TC4 - PLASMODIUM FALCIPARUM.
RAN_TETPY GTP-BINDING NUCLEAR PROTEIN RAN/TC4 - TETRAHYMENA PYRIFORMIS.
RAN_TETTH GTP-BINDING NUCLEAR PROTEIN RAN/TC4 - TETRAHYMENA THERMOPHILA.
RAN_VICFA GTP-BINDING NUCLEAR PROTEIN RAN/TC4 - VICIA FABA (BROAD BEAN).
SPI1_SCHPO GTP-BINDING NUCLEAR PROTEIN SPI1 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
Scan History
OWL28_3    2  100  NSINGLE    
SPTR37_9f 2 27 NSINGLE
Initial Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
TTFVKRHLTGEFEKK RANA_TOBAC 27 27 -
TTFVKRHLTGEFEKK RANB_TOBAC 27 27 -
TTFVKRHLTGEFEKK RAN_VICFA 27 27 -
TTFVKRHLTGEFEKK RAN1_LYCES 27 27 -
TTFVKRHLTGEFEKK RAN2_ARATH 9 9 -
TTFVKRHLTGEFEKK RAN2_LYCES 27 27 -
TTFVKRHLTGEFEKK RAN1_ARATH 27 27 -
TTFVKRHLTGEFEKK RAN_CHICK 24 24 -
TTFVKRHLTGEFEKK RAN_HUMAN 24 24 -
TTFVKRHLTGDFEKK RAN_BRUMA 23 23 -
TTFVKRHLTGDPEKK RAN_ONCVO 23 23 -
TTFVKRHLTGEFEKK RAN_PLAFA 23 23 -
TTFVTRHQTGEFEKR RAN_TETPY 25 25 -
TTFVTRHQTGEFEKR RAN_TETTH 25 25 -
TTFVQRHLTGEFEPR RAN_DICDI 20 20 -
TTFVTRHITGEFRKQ RAN_GIALA 20 20 -

Motif 2 width=19
Element Seqn Id St Int Rpt
KFGGLRDGYYIHGQCAIIM RANA_TOBAC 74 32 -
KFGGLRDGYYIHGQCAIIM RANB_TOBAC 74 32 -
KFGGLRDGYYIHGQCAIIM RAN_VICFA 74 32 -
KFGGLRDGYYIHGQCAIIM RAN1_LYCES 74 32 -
KFGGLRDGYYIHGQCAIIM RAN2_ARATH 56 32 -
KFGGLRDGYYIHGQCAIIM RAN2_LYCES 74 32 -
KFGGLRDGYYIHGQCAIIM RAN1_ARATH 74 32 -
KFGGLRDGYYIQAQCAIIM RAN_CHICK 71 32 -
KFGGLRDGYYIQAQCAIIM RAN_HUMAN 71 32 -
KFGGLRDGYYIQGQCAFNM RAN_BRUMA 70 32 -
KFGGLRDGYYIQGQCAIIM RAN_ONCVO 70 32 -
KFGGLRDGYYIKSDCAIIM RAN_PLAFA 70 32 -
KLGGLREGYYIGADAAIMM RAN_TETPY 72 32 -
KLGGLREGYYIGANAAIMM RAN_TETTH 72 32 -
KFGGLRDGYYIQGNCAIIM RAN_DICDI 67 32 -
KFGGLRDGYYVDSDACLLF RAN_GIALA 73 38 -

Motif 3 width=22
Element Seqn Id St Int Rpt
DVTARLTYKNVPTWHRDLCRVC RANA_TOBAC 94 1 -
DVTARLTYKNVPTWHRDLCRVC RANB_TOBAC 94 1 -
DVTARLTYKNVPTWHRDLCRVC RAN_VICFA 94 1 -
DVTARLTYKNVPTWHRDLCRVC RAN1_LYCES 94 1 -
DVTARLTYKNVPTWHRDLCRVC RAN2_ARATH 76 1 -
DVTARLTYKNVPTWHRDLCRVC RAN2_LYCES 94 1 -
DVTARLTYKNVPTWHRDLCRVC RAN1_ARATH 94 1 -
DVTSRVTYKNVPNWHRDLVRVC RAN_CHICK 91 1 -
DVTSRVTYKNVPNWHRDLVRVC RAN_HUMAN 91 1 -
DVTARVTYKNVPNWHRDLVRVC RAN_BRUMA 90 1 -
DVTARVTYKNVPNWHRDLARVC RAN_ONCVO 90 1 -
DVSSRITYKNVPNWYRDITRVC RAN_PLAFA 90 1 -
DVTSRITYKNIPKWHKDLTRIC RAN_TETPY 92 1 -
DVTSRITYKNIPKWHKDLTRIC RAN_TETTH 92 1 -
DVTSRISYKNVPNWHSDLTRVC RAN_DICDI 87 1 -
DVTNRVTYKNVESWYRDVFRIC RAN_GIALA 93 1 -

Motif 4 width=19
Element Seqn Id St Int Rpt
KNRQVKAKQVTFHRKKNLQ RANA_TOBAC 130 14 -
KNRQVKAKQVTFHRKKNLQ RANB_TOBAC 130 14 -
KNRQVKAKQVTFHRKKNLQ RAN_VICFA 130 14 -
KNRQVKAKQVTFHRKKNLQ RAN1_LYCES 130 14 -
KNRQVKAKQVTFHRKKNLQ RAN2_ARATH 112 14 -
KNRQVKAKQVTFHRKKNLQ RAN2_LYCES 130 14 -
KNRQVKAKQVTFHRKKNLQ RAN1_ARATH 130 14 -
KDRKVKAKSIVFHRKKNLQ RAN_CHICK 127 14 -
KDSKVKAKSIVFHRKKNLQ RAN_HUMAN 127 14 -
KDRKVKAKTITFHRKKNLQ RAN_BRUMA 126 14 -
KDRKVKAKTITFHRKKNLQ RAN_ONCVO 126 14 -
KDRQVKSRQIQFHRKRNLQ RAN_PLAFA 126 14 -
KDSKVKARQITFHRKRSLQ RAN_TETPY 128 14 -
KDRKVKARQITFHRKRSLQ RAN_TETTH 128 14 -
KDRKVKPSQIVFHRRYNLS RAN_DICDI 123 14 -
KDREIRTQTVKFHRSKNIP RAN_GIALA 140 25 -

Motif 5 width=23
Element Seqn Id St Int Rpt
ARKLAGDPNLHFVESPALAPPEV RANA_TOBAC 168 19 -
ARKLAGDANLHFVESPALAPPEV RANB_TOBAC 168 19 -
ARKLAGDANLHFVESPALAPPEV RAN_VICFA 168 19 -
ARKLAGDGNLHFVESPALAPPEV RAN1_LYCES 168 19 -
ARKLAGDQNLHFVESPALAPPEV RAN2_ARATH 150 19 -
ARKLAGDGNLHFVESPALAPPEV RAN2_LYCES 168 19 -
ARKLAGDQNLHFVETPALAPPEV RAN1_ARATH 168 19 -
ARKLIGDPNLEFVAMPALAPPEV RAN_CHICK 165 19 -
ARKLIGDPNLEFVAMPALAPPEV RAN_HUMAN 165 19 -
ARKLLGDPNLEFVAMPALAPPEV RAN_BRUMA 164 19 -
VRKLLGDPNLEFVAMPALAPPEV RAN_ONCVO 164 19 -
ARRLSNQPNLVFVGEHAKAPEFQ RAN_PLAFA 164 19 -
LRKLTGDPNLNLVEGIALAPVDI RAN_TETPY 166 19 -
LRKLTGDPTLNLVEGIALVAPDT RAN_TETTH 166 19 -
TSKLLGNKAVTLVQQPTLKLPET RAN_DICDI 161 19 -
LRTLLNDPTIQFSQAPALLPADI RAN_GIALA 178 19 -
Final Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
TTFVKRHLTGEFEKK RANA_TOBAC 27 27 -
TTFVKRHLTGEFEKK O04664 27 27 -
TTFVKRHLTGEFEKK RANB_TOBAC 27 27 -
TTFVKRHLTGEFEKK RAN_VICFA 27 27 -
TTFVKRHLTGEFEKK RAN1_LYCES 27 27 -
TTFVKRHLTGEFEKK RAN2_ARATH 9 9 -
TTFVKRHLTGEFEKK RAN2_LYCES 27 27 -
TTFVKRHLTGEFEKK O17915 23 23 -
TTFVKRHLTGEFEKK RAN1_ARATH 27 27 -
TTFVKRHLTGEFEKK RAN_CHICK 24 24 -
TTFVKRHLTGEFEKK RAN_MOUSE 24 24 -
TTFVKRHLTGEPEKK O04148 27 27 -
TTFVKRHLTGEFEKK RAN_BRARE 23 23 -
TTFVKRHLTGEFEKK RAN_HUMAN 24 24 -
TTFVKRHLTGEFEKK GSP1_YEAST 26 26 -
TTFVKRHLTGEFEKK GSP2_YEAST 27 27 -
TTFVKRHLTGEFEKK O22495 27 27 -
TTFVKRHLTGDFEKK RAN_BRUMA 23 23 -
TTFVKRHLTGDPEKK RAN_ONCVO 23 23 -
TTFVKRHLTGEFEKK SPI1_SCHPO 23 23 -
TTFMKRHLTGEFEKE RANT_MOUSE 24 24 -
TTFVKRHLTGEFEKK RAN_PLAFA 23 23 -
TTFVTRHQTGEFEKR RAN_TETPY 25 25 -
TTFVTRHQTGEFEKR RAN_TETTH 25 25 -
TTFVQRHLTGEFEPR RAN_DICDI 20 20 -
TTFVTRHITGEFRKQ RAN_GIALA 20 20 -

Motif 2 width=19
Element Seqn Id St Int Rpt
KFGGLRDGYYIHGQCAIIM RANA_TOBAC 74 32 -
KFGGLRDGYYIHGQCAIIM O04664 74 32 -
KFGGLRDGYYIHGQCAIIM RANB_TOBAC 74 32 -
KFGGLRDGYYIHGQCAIIM RAN_VICFA 74 32 -
KFGGLRDGYYIHGQCAIIM RAN1_LYCES 74 32 -
KFGGLRDGYYIHGQCAIIM RAN2_ARATH 56 32 -
KFGGLRDGYYIHGQCAIIM RAN2_LYCES 74 32 -
KFGGLRDGYYIQGQCAIIM O17915 70 32 -
KFGGLRDGYYIHGQCAIIM RAN1_ARATH 74 32 -
KFGGLRDGYYIQAQCAIIM RAN_CHICK 71 32 -
KFGGLRDGYYIQAQCAIIM RAN_MOUSE 71 32 -
KFGGLRDGYYIHGQCAIIM O04148 74 32 -
KFGGLRDGYYIQAQCAIIM RAN_BRARE 70 32 -
KFGGLRDGYYIQAQCAIIM RAN_HUMAN 71 32 -
KFGGLRDGYYINAQCAIIM GSP1_YEAST 73 32 -
KFGGLRDGYYINAQCAIIM GSP2_YEAST 74 32 -
KFGGLRDGYYIHGQCAIIM O22495 74 32 -
KFGGLRDGYYIQGQCAFNM RAN_BRUMA 70 32 -
KFGGLRDGYYIQGQCAIIM RAN_ONCVO 70 32 -
KLGGLRDGYYIQGQCGIIM SPI1_SCHPO 70 32 -
KFGGLRDGYYIQAQCAIIM RANT_MOUSE 71 32 -
KFGGLRDGYYIKSDCAIIM RAN_PLAFA 70 32 -
KLGGLREGYYIGADAAIMM RAN_TETPY 72 32 -
KLGGLREGYYIGANAAIMM RAN_TETTH 72 32 -
KFGGLRDGYYIQGNCAIIM RAN_DICDI 67 32 -
KFGGLRDGYYVDSDACLLF RAN_GIALA 73 38 -

Motif 3 width=22
Element Seqn Id St Int Rpt
DVTARLTYKNVPTWHRDLCRVC RANA_TOBAC 94 1 -
DVTARLTYKNVPTWHRDLCRVC O04664 94 1 -
DVTARLTYKNVPTWHRDLCRVC RANB_TOBAC 94 1 -
DVTARLTYKNVPTWHRDLCRVC RAN_VICFA 94 1 -
DVTARLTYKNVPTWHRDLCRVC RAN1_LYCES 94 1 -
DVTARLTYKNVPTWHRDLCRVC RAN2_ARATH 76 1 -
DVTARLTYKNVPTWHRDLCRVC RAN2_LYCES 94 1 -
DVTARVTYKNVPNWHRDLARVC O17915 90 1 -
DVTARLTYKNVPTWHRDLCRVC RAN1_ARATH 94 1 -
DVTSRVTYKNVPNWHRDLVRVC RAN_CHICK 91 1 -
DVTSRVTYKNVPNWHRDLVRVC RAN_MOUSE 91 1 -
DVTARLTYKNVPTWHRDLCRVC O04148 94 1 -
DVTSRVTYKNVPNWHRDLVRVC RAN_BRARE 90 1 -
DVTSRVTYKNVPNWHRDLVRVC RAN_HUMAN 91 1 -
DVTSRITYKNVPNWHRDLVRVC GSP1_YEAST 93 1 -
DVTSRITYKNVPNWHRDLVRVC GSP2_YEAST 94 1 -
DVTARLTYRNVPTWHRDLCRVC O22495 94 1 -
DVTARVTYKNVPNWHRDLVRVC RAN_BRUMA 90 1 -
DVTARVTYKNVPNWHRDLARVC RAN_ONCVO 90 1 -
DVTSRITYKNVPHWWRDLVRVC SPI1_SCHPO 90 1 -
DVTSRVTYKNVPSWHKDLVRVC RANT_MOUSE 91 1 -
DVSSRITYKNVPNWYRDITRVC RAN_PLAFA 90 1 -
DVTSRITYKNIPKWHKDLTRIC RAN_TETPY 92 1 -
DVTSRITYKNIPKWHKDLTRIC RAN_TETTH 92 1 -
DVTSRISYKNVPNWHSDLTRVC RAN_DICDI 87 1 -
DVTNRVTYKNVESWYRDVFRIC RAN_GIALA 93 1 -

Motif 4 width=19
Element Seqn Id St Int Rpt
KNRQVKAKQVTFHRKKNLQ RANA_TOBAC 130 14 -
KNRQVKAKQVTFHRKKNLQ O04664 130 14 -
KNRQVKAKQVTFHRKKNLQ RANB_TOBAC 130 14 -
KNRQVKAKQVTFHRKKNLQ RAN_VICFA 130 14 -
KNRQVKAKQVTFHRKKNLQ RAN1_LYCES 130 14 -
KNRQVKAKQVTFHRKKNLQ RAN2_ARATH 112 14 -
KNRQVKAKQVTFHRKKNLQ RAN2_LYCES 130 14 -
KDRKVKAKTITFHRKKNLQ O17915 126 14 -
KNRQVKAKQVTFHRKKNLQ RAN1_ARATH 130 14 -
KDRKVKAKSIVFHRKKNLQ RAN_CHICK 127 14 -
KDRKVKAKSIVFHRKKNLQ RAN_MOUSE 127 14 -
KNRQVKAKQVTFHRKKNLQ O04148 130 14 -
KDRKVKAKSIVFHRKKNLQ RAN_BRARE 126 14 -
KDSKVKAKSIVFHRKKNLQ RAN_HUMAN 127 14 -
KERKVKAKTITFHRKKNLQ GSP1_YEAST 129 14 -
KERKVKAKTITFHRKKNLQ GSP2_YEAST 130 14 -
KNRQVKAKQVTFHRKEELQ O22495 130 14 -
KDRKVKAKTITFHRKKNLQ RAN_BRUMA 126 14 -
KDRKVKAKTITFHRKKNLQ RAN_ONCVO 126 14 -
KERKVKAKAITFHRKKNLQ SPI1_SCHPO 126 14 -
KDMKVKAKPILFHRKKNLQ RANT_MOUSE 127 14 -
KDRQVKSRQIQFHRKRNLQ RAN_PLAFA 126 14 -
KDSKVKARQITFHRKRSLQ RAN_TETPY 128 14 -
KDRKVKARQITFHRKRSLQ RAN_TETTH 128 14 -
KDRKVKPSQIVFHRRYNLS RAN_DICDI 123 14 -
KDREIRTQTVKFHRSKNIP RAN_GIALA 140 25 -

Motif 5 width=23
Element Seqn Id St Int Rpt
ARKLAGDPNLHFVESPALAPPEV RANA_TOBAC 168 19 -
ARKLAGDANLHFVESPALAPPEV O04664 168 19 -
ARKLAGDANLHFVESPALAPPEV RANB_TOBAC 168 19 -
ARKLAGDANLHFVESPALAPPEV RAN_VICFA 168 19 -
ARKLAGDGNLHFVESPALAPPEV RAN1_LYCES 168 19 -
ARKLAGDQNLHFVESPALAPPEV RAN2_ARATH 150 19 -
ARKLAGDGNLHFVESPALAPPEV RAN2_LYCES 168 19 -
ARKLLGDPNLEFVAMPALAPPEV O17915 164 19 -
ARKLAGDQNLHFVETPALAPPEV RAN1_ARATH 168 19 -
ARKLIGDPNLEFVAMPALAPPEV RAN_CHICK 165 19 -
ARKLIGDPNLEFVAMPALAPPEV RAN_MOUSE 165 19 -
ARKLAGDANLHFVESPALAPPEV O04148 168 19 -
ARKLIGDPNLEFVEMPALAPPEI RAN_BRARE 164 19 -
ARKLIGDPNLEFVAMPALAPPEV RAN_HUMAN 165 19 -
ARKLAGNPQLEFVASPALAPPEV GSP1_YEAST 167 19 -
ARKLAGNPQLEFVASPALAPPEV GSP2_YEAST 168 19 -
ARKLAGDANLHFVESPALAPPEV O22495 168 19 -
ARKLLGDPNLEFVAMPALAPPEV RAN_BRUMA 164 19 -
VRKLLGDPNLEFVAMPALAPPEV RAN_ONCVO 164 19 -
ARKLVGNPNLEFVASPALAPPEV SPI1_SCHPO 164 19 -
ARKLIGDPNLEFVAMPALAPPEV RANT_MOUSE 165 19 -
ARRLSNQPNLVFVGEHAKAPEFQ RAN_PLAFA 164 19 -
LRKLTGDPNLNLVEGIALAPVDI RAN_TETPY 166 19 -
LRKLTGDPTLNLVEGIALVAPDT RAN_TETTH 166 19 -
TSKLLGNKAVTLVQQPTLKLPET RAN_DICDI 161 19 -
LRTLLNDPTIQFSQAPALLPADI RAN_GIALA 178 19 -