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PR00546

Identifier
THYROIDHORMR  [View Relations]  [View Alignment]  
Accession
PR00546
No. of Motifs
9
Creation Date
07-JUN-1996  (UPDATE 15-JUN-1999)
Title
Thyroid hormone receptor (1D nuclear receptor) signature
Database References
PRINTS; PR00398 STRDHORMONER
INTERPRO; IPR001728
Literature References
1. NUCLEAR RECEPTORS NOMENCLATURE COMMITTEE
A unified nomenclature system for the nuclear receptor superfamily.
CELL 97 161-163 (1999).
 
2. NISHIKAWA, J-I., KITAURA, M., IMAGAWA, M. AND NISHIHARA, T.
Vitamin D receptor contains multiple dimerisation interfaces that
are functionally different.
NUCLEIC ACIDS RES. 23(4) 606-611 (1995).
 
3. DE VOS, P., SCHMITT, J., VERHOEVEN, G. AND STUNNENBERG, G.
Human androgen receptor expressed in HeLa cells activates transcription
in vitro.
NUCLEIC ACIDS RES. 22(7) 1161-1166 (1994).
 
4. WAGNER, R.L., APRILETTI, J.W., MCGRATH, M.E., WEST, B.L., BAXTER, J.D.
AND FLETTERICK, R.J.
A structural role for hormone in the thyroid hormone receptor.
NATURE 378 690-697 (1995).
 
5. CHEN, J.D. AND EVANS, R.M.
A transcriptional co-repressor that interacts with nuclear hormone
receptors.
NATURE 377 454-457 (1995).

Documentation
Steroid or nuclear hormone receptors (NRs) constitute an important super-
family of transcription regulators that are involved in widely diverse 
physiological functions, including control of embryonic development, cell
differentiation and homeostasis [1]. Members of the superfamily include the
steroid hormone receptors and receptors for thyroid hormone, retinoids, 
1,25-dihydroxy-vitamin D3 and a variety of other ligands. The proteins 
function as dimeric molecules in nuclei to regulate the transcription of 
target genes in a ligand-responsive manner [1,2]. In addition to C-terminal
ligand-binding domains, these nuclear receptors contain a highly-conserved,
N-terminal zinc-finger that mediates specific binding to target DNA 
sequences, termed ligand-responsive elements. In the absence of ligand,
steroid hormone receptors are thought to be weakly associated with nuclear
components; hormone binding greatly increases receptor affinity.
 
NRs are extremely important in medical research, a large number of them
being implicated in diseases such as cancer, diabetes, hormone resistance
syndromes, etc. [1]. While several NRs act as ligand-inducible transcription
factors, many do not yet have a defined ligand and are accordingly termed 
"orphan" receptors. During the last decade, more than 300 NRs have been
described, many of which are orphans, which cannot easily be named due to 
current nomenclature confusions in the literature. However, a new system 
has recently been introduced in an attempt to rationalise the increasingly 
complex set of names used to describe superfamily members [1].
 
In common with other members of the steroid hormone receptor family, thyroid
hormone receptors (TRs) contain 2 major highly-conserved domains, involved
in DNA- and ligand-binding respectively. Except for a conserved 12-residue
motif adjacent to the DNA-binding domain, the N-terminal domains are 
divergent between alpha- and beta-TR isoforms (but are conserved within
isoforms). The DNA-binding domain is the most highly conserved feature of
the family; it contains 2 zinc-binding modules (zinc fingers). The ligand-
binding domain [4] includes a number of conserved motifs, parts of which
are thought to be involved in dimerisation. The hinge region between these
2 domains [5] is thought to contain the binding site for transcriptional
co-repressor proteins that mediate the transcriptional repression function
of unliganded receptors: for more information see the TRR resource at
http://xanadu.mgh.harvard.edu//receptor/trrfront.html. 
 
THYROIDHORMR is a 9-element fingerprint that provides a signature for the
thyroid hormone receptors. The fingerprint was derived from an initial
alignment of 17 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length, focusing on those areas of
the alignment that characterise the TRs but distinguish them from the
rest of the steroid hormone receptor family - motif 1 lies at the
N-terminus just prior to the DNA-binding domain; and motifs 2-9 span the
hinge and ligand-binding regions. Two iterations on OWL28.0 were required
to reach convergence, at which point a true set comprising 40 sequences
was identified. Three partial matches were also found (RATERBAA2, JC4014
and MMU9419), all of which are steroid hormone receptor family members.
 
An update on SPTR37_9f identified a true set of 29 sequences, and 1
partial match.
Summary Information
  29 codes involving  9 elements
0 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
1 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
9292929292929292929
8000000000
7000000000
6000000000
5000000000
4000000000
3101000100
2000000000
123456789
True Positives
ERBA_AVIER    Q13986        Q64895        Q91911        
THA1_BRARE THA1_HUMAN THA1_MOUSE THA1_SHEEP
THA2_HUMAN THA2_RAT THAA_PAROL THAA_XENLA
THAB_PAROL THAB_XENLA THA_CHICK THA_RANCA
THB1_HUMAN THB1_MOUSE THB1_RAT THB1_XENLA
THB2_HUMAN THB2_MOUSE THB2_RAT THB5_XENLA
THB6_XENLA THB7_XENLA THB_CHICK THB_PAROL
THB_RANCA
True Positive Partials
Codes involving 3 elements
O77154
Sequence Titles
ERBA_AVIER  ERBA ONCOGENE PROTEIN - AVIAN ERYTHROBLASTOSIS VIRUS (STRAIN ES4). 
Q13986 C-ERBA - HOMO SAPIENS (HUMAN).
Q64895 GAG GENE - AVIAN ERYTHROBLASTOSIS VIRUS (STRAIN TS167).
Q91911 THYROID HORMONE RECEPTOR ALPHA-B - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
THA1_BRARE THYROID HORMONE RECEPTOR ALPHA 1 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
THA1_HUMAN THYROID HORMONE RECEPTOR ALPHA-1 (EAR-7-1) (C-ERBA-ALPHA-1) - HOMO SAPIENS (HUMAN).
THA1_MOUSE THYROID HORMONE RECEPTOR ALPHA-1 - MUS MUSCULUS (MOUSE), AND RATTUS NORVEGICUS (RAT).
THA1_SHEEP THYROID HORMONE RECEPTOR ALPHA-1 - OVIS ARIES (SHEEP).
THA2_HUMAN THYROID HORMONE RECEPTOR ALPHA-2 (EAR-7-2) (C-ERBA-ALPHA-2) - HOMO SAPIENS (HUMAN).
THA2_RAT THYROID HORMONE RECEPTOR ALPHA-2 - RATTUS NORVEGICUS (RAT).
THAA_PAROL THYROID HORMONE RECEPTOR ALPHA A (THR-ALPHA-A) - PARALICHTHYS OLIVACEUS (FLOUNDE
THAA_XENLA THYROID HORMONE RECEPTOR ALPHA-A - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
THAB_PAROL THYROID HORMONE RECEPTOR ALPHA B (THR-ALPHA-B) - PARALICHTHYS OLIVACEUS (FLOUNDE
THAB_XENLA THYROID HORMONE RECEPTOR ALPHA-B - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
THA_CHICK THYROID HORMONE RECEPTOR ALPHA - GALLUS GALLUS (CHICKEN).
THA_RANCA THYROID HORMONE RECEPTOR ALPHA - RANA CATESBEIANA (BULL FROG).
THB1_HUMAN THYROID HORMONE RECEPTOR BETA-1 - HOMO SAPIENS (HUMAN).
THB1_MOUSE THYROID HORMONE RECEPTOR BETA-1 - MUS MUSCULUS (MOUSE).
THB1_RAT THYROID HORMONE RECEPTOR BETA-1 - RATTUS NORVEGICUS (RAT).
THB1_XENLA THYROID HORMONE RECEPTOR BETA-A - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
THB2_HUMAN THYROID HORMONE RECEPTOR BETA-2 - HOMO SAPIENS (HUMAN).
THB2_MOUSE THYROID HORMONE RECEPTOR BETA-2 - MUS MUSCULUS (MOUSE).
THB2_RAT THYROID HORMONE RECEPTOR BETA-2 - RATTUS NORVEGICUS (RAT).
THB5_XENLA
THB6_XENLA THYROID HORMONE RECEPTOR BETA-B - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
THB7_XENLA
THB_CHICK THYROID HORMONE RECEPTOR BETA - GALLUS GALLUS (CHICKEN), AND CAIRINA MOSCHATA (MUSCOVY DUCK).
THB_PAROL THYROID HORMONE RECEPTOR BETA (THR-BETA) - PARALICHTHYS OLIVACEUS (FLOUNDER).
THB_RANCA THYROID HORMONE RECEPTOR BETA - RANA CATESBEIANA (BULL FROG).

O77154 NUCLEAR RECEPTOR 1 - CIONA INTESTINALIS.
Scan History
OWL28_0    2  50   NSINGLE    
SPTR37_9f 2 30 NSINGLE
Initial Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
GYIPSYLDKDEQCVV THA_CHICK 39 39 -
GYIPSYLTKDEPCVV THA_RANCA 49 49 -
GYIPSYLDKDEPCVV THAA_XENLA 49 49 -
GYIPSYLDKDEPCVV THAB_XENLA 49 49 -
GYIPSYLDKDEQCVV THA2_RAT 41 41 -
GYIPSYLDKDEQCVV THA1_MOUSE 41 41 -
GYIPSYLDKDEQCVV THA2_HUMAN 41 41 -
GYIPSYLDKDEQCVV THA1_HUMAN 41 41 -
GYIPSYLDKDEQCVV THA1_RAT 41 41 -
GYIPSYLDKDELCVV THB1_HUMAN 95 95 -
GYIPSYLDKDELCVV THB_CHICK 3 3 -
GYIPSYLDKDELCVV THB2_HUMAN 110 110 -
GYIPSYLDKDELCVV THB1_MOUSE 95 95 -
GYIPSYLDKDELCVV THB1_RAT 95 95 -
GYIPSYLDKDELCVV THB2_MOUSE 109 109 -
GYIPSYLDKDELCVV THB2_RAT 148 148 -
GYIPSYLDKDELCVV THB6_XENLA 7 7 -

Motif 2 width=12
Element Seqn Id St Int Rpt
RTIQKNLHPTYS THA_CHICK 77 23 -
RTIQKNLHPSYS THAA_XENLA 87 23 -
RTIQKNLHPSYS THAB_XENLA 87 23 -
RTIQKNLHPTYS THA2_RAT 79 23 -
RTIQKNLHPTYS THA1_MOUSE 79 23 -
RTIQKNLHPTYS THA2_HUMAN 79 23 -
RTIQKNLHPTYS THA1_HUMAN 79 23 -
RTIQKNLHPTYS THA1_RAT 79 23 -
RTIQKNLHPSYS THB1_HUMAN 133 23 -
RTIQKNLHPTYS THB_CHICK 41 23 -
RTIQKNLHPSYS THB2_HUMAN 148 23 -
RTIQKSLHPSYS THB1_MOUSE 133 23 -
RTIQKSLHPSYS THB1_RAT 133 23 -
RTIQKSLHPSYS THB2_MOUSE 147 23 -
RTIQKSLHPSYS THB2_RAT 186 23 -
RTIQKNLHPSYS THB6_XENLA 45 23 -
RTIQKNLHPSYS THA_RANCA 87 23 -

Motif 3 width=17
Element Seqn Id St Int Rpt
VGMAMDLVLDDSKRVAK THA_RANCA 126 27 -
VGMAMDLDLDDSKRVAK THAB_XENLA 126 27 -
VGMAMDLVLDDSKRVAK THA2_RAT 118 27 -
VGMAMDLVLDDSKRVAK THA1_MOUSE 118 27 -
VGMAMDLVLDDSKRVAK THA2_HUMAN 118 27 -
VGMAMDLVLDDSKRVAK THA1_HUMAN 118 27 -
VGMAMDLVLDDSKRVAK THA1_RAT 118 27 -
VGMATDLVLDDSKRLAK THB1_HUMAN 172 27 -
VGMATDLVLDDSKRLAK THB_CHICK 80 27 -
VGMATDLVLDDSKRLAK THB2_HUMAN 187 27 -
VGMATDLVLDDSKRLAK THB1_MOUSE 172 27 -
VGMATDLVLDDSKRLAK THB1_RAT 172 27 -
VGMATDLVLDDSKRLAK THB2_MOUSE 186 27 -
VGMATDLVLDDSKRLAK THB2_RAT 225 27 -
VGMATDLVLDDSKRLAK THB6_XENLA 84 27 -
VGMAMDLVLDDSKRVAK THA_CHICK 116 27 -
VGMAMDLVLDDGKRVAK THAA_XENLA 126 27 -

Motif 4 width=19
Element Seqn Id St Int Rpt
RKLIEENRQRRRKEEMIKT THAA_XENLA 143 0 -
RKLIEQNRERRRKEEMIRS THA2_RAT 135 0 -
RKLIEQNRERRRKEEMIRS THA1_RAT 135 0 -
RKLIEQNRERRRKEEMIRS THA1_HUMAN 135 0 -
RKLIEQNRERRRKEEMIRS THA2_HUMAN 135 0 -
RKLIEQNRERRRKEEMIRS THA1_MOUSE 135 0 -
RKLIEENREKRRREELQKS THB1_HUMAN 189 0 -
RKLIEENREKRRREELQKT THB_CHICK 97 0 -
RKLIEENREKRRREELQKS THB2_HUMAN 204 0 -
RKLIEENREKRRREELQKS THB1_MOUSE 189 0 -
RKLIEENREKRRREELQKS THB1_RAT 189 0 -
RKLIEENREKRRREELQKS THB2_MOUSE 203 0 -
RKLIEENREKRRREELQKS THB2_RAT 242 0 -
RKLIEENREKRRKDEIQKS THB6_XENLA 101 0 -
RKLIEENRERRRKEEMIKS THA_CHICK 133 0 -
RKLIEENRERRRKEEMIKT THA_RANCA 143 0 -
RKLIEEDRVRRRKEEMIKT THAB_XENLA 143 0 -

Motif 5 width=18
Element Seqn Id St Int Rpt
PEPTDEEWELIKTVTEAH THB1_MOUSE 212 4 -
PEPTPEEWDLIHVATEAH THA1_RAT 158 4 -
PEPTDEEWELIKTVTEAH THB1_HUMAN 212 4 -
PEPTDEEWELIKIVTEAH THB_CHICK 120 4 -
PEPTDEEWELIKTVTEAH THB2_HUMAN 227 4 -
PEPTDEEWELIKTVTEAH THB1_RAT 212 4 -
PEPTDEEWELIKTVTEAH THB2_MOUSE 226 4 -
PEPTDEEWELIKTVTEAH THB2_RAT 265 4 -
PEPTQEEWELIQVVTEAH THB6_XENLA 124 4 -
PSPSAEEWELIHVVTEAH THA_CHICK 156 4 -
PEPSSEEWELIRIVTEAH THA_RANCA 166 4 -
PEPSSEEWELIRIVTEAH THAA_XENLA 166 4 -
PEPSSEEWELIRIVTEAH THAB_XENLA 166 4 -
PEPTPEEWDLIHVATEAH THA2_RAT 158 4 -
PEPTPEEWDLIHVATEAH THA1_MOUSE 158 4 -
PEPTPEEWDLIHIATEAH THA2_HUMAN 158 4 -
PEPTPEEWDLIHIATEAH THA1_HUMAN 158 4 -

Motif 6 width=20
Element Seqn Id St Int Rpt
QGSHWKQRRKFLPDDIGQSP THA1_MOUSE 181 5 -
QGSHWKQRRKFLPDDIGQSP THA1_RAT 181 5 -
QGSHWKQRRKFLPDDIGQSP THA1_HUMAN 181 5 -
QGSHWKQRRKFLPDDIGQSP THA2_HUMAN 181 5 -
QGSHWKQKRKFLPEDIGQAP THB1_HUMAN 235 5 -
QGSHWKQKRKFLPEDIGQAP THB_CHICK 143 5 -
QGSHWKQKPKFLPEDIGQAP THB2_HUMAN 250 5 -
QGSHWKQKRKFLPEDIGQAP THB1_MOUSE 235 5 -
QGSHWKQKRKFLPEDIGQAP THB1_RAT 235 5 -
QGSHWKQKRKFLPEDIGQAP THB2_MOUSE 249 5 -
QGSHWKQKRKFLPEDIGQAP THB2_RAT 288 5 -
QGSHWKQKRKFLPEDIGQAP THB6_XENLA 147 5 -
QGSHWKQKRKFLPEDIGQSP THA_CHICK 179 5 -
QGSHWKQRRKFLPEDIGQNP THA_RANCA 189 5 -
QGSHWKQRRKFLPEDIGQSP THAA_XENLA 189 5 -
QGSHWKQRRKFLPEDIGQSP THAB_XENLA 189 5 -
QGSHWKQRRKFLPDDIGQSP THA2_RAT 181 5 -

Motif 7 width=22
Element Seqn Id St Int Rpt
FTKIITPAITRVVDFAKKLPMF THB2_RAT 325 17 -
FTKIITPAITRVVDFAKKLPMF THB1_HUMAN 272 17 -
FTKIITPAITRVVDFAKKLPMF THB_CHICK 180 17 -
FTKIITPAITRVVDFAKKLPMF THB2_HUMAN 287 17 -
FTKIITPAITRVVDFAKKLPMF THB1_MOUSE 272 17 -
FTKIITPAITRVVDFAKKLPMF THB1_RAT 272 17 -
FTKIITPAITRVVDFAKKLPMF THB2_MOUSE 286 17 -
FTKIITPAITRVVDFAKKLPMF THB6_XENLA 184 17 -
FTKIITPAITRVVDFAKKLPMF THA_CHICK 216 17 -
FTKIITPAITRVVDFAKKLPMF THA_RANCA 226 17 -
FTKIITPAITRVVDFAKKLPMF THAA_XENLA 226 17 -
FTKIITPAITRVVDFAKKLPMF THAB_XENLA 226 17 -
FTKIITPAITRVVDFAKKLPMF THA2_RAT 218 17 -
FTKIITPAITRVVDFAKKLPMF THA1_MOUSE 218 17 -
FTKIITPAITRVVDFAKKLPMF THA2_HUMAN 218 17 -
FTKIITPAITRVVDFAKKLPMF THA1_HUMAN 218 17 -
FTKIITPAITRVVDFAKKLPMF THA1_RAT 218 17 -

Motif 8 width=20
Element Seqn Id St Int Rpt
CEDQIILLKGCCMEIMSLRA THA1_HUMAN 244 4 -
CEDQIILLKGCCMEIMSLRA THB1_HUMAN 298 4 -
CEDQIILLKGCCMEIMSLRA THB_CHICK 206 4 -
CEDQIILLKGCCMEIMSLRA THB2_HUMAN 313 4 -
CEDQIILLKGCCMEIMSLRA THB1_MOUSE 298 4 -
CEDQIILLKGCCMEIMSLRA THA1_RAT 244 4 -
CEDQIILLKGCCMEIMSLRA THB1_RAT 298 4 -
CEDQIILLKGCCMEIMSLRA THB2_MOUSE 312 4 -
CEDQIILLKGCCMEIMSLRA THB2_RAT 351 4 -
CEDQIILLKGCCMEIMSLRA THB6_XENLA 210 4 -
CEDQIILLKGCCMEIMSLRA THA_CHICK 242 4 -
CEDQIILLKGCCMEIMSLRA THA_RANCA 252 4 -
CEDQIILLKGCCMEIMSLRA THAA_XENLA 252 4 -
CEDQIILLKGCCMEIMSLRA THAB_XENLA 252 4 -
CEDQIILLKGCCMEIMSLRA THA2_RAT 244 4 -
CEDQIILLKGCCMEIMSLRA THA1_MOUSE 244 4 -
CEDQIILLKGCCMEIMSLRA THA2_HUMAN 244 4 -

Motif 9 width=23
Element Seqn Id St Int Rpt
FNLDDTEVALLQAVLLMSSDRTG THA_CHICK 307 45 -
FNLDDTEVALLQAVLLMSSDRTG THAA_XENLA 317 45 -
FNLDDTEVALLQAVLLMSTDRSG THA1_HUMAN 309 45 -
FNLDDTEVALLQAVLLMSTDRSG THA2_HUMAN 309 45 -
FNLDDTEVALLQAVLLMSSDRPG THB1_HUMAN 363 45 -
FNLDDTEVALLQAVLLMSTDRSG THA1_RAT 309 45 -
FNLDDTEVALLQAVLLMSSDRTG THAB_XENLA 317 45 -
FNLDDTEVALLQAVLLMSSDRPG THB_CHICK 271 45 -
FNLDDTEVALLQAVLLMSSDRPG THB2_HUMAN 378 45 -
FNLDDTEVALLQAVLLMSTDRSG THA2_RAT 309 45 -
FNLDDTEVALLQAVLLMSSDRPG THB1_MOUSE 363 45 -
FNLDDTEVALLQAVLLMSTDRSG THA1_MOUSE 309 45 -
FNLDDTEVALLQAVLLMSSDRPG THB1_RAT 363 45 -
FNLDDTEVALLQAVLLMSSDRPG THB2_MOUSE 377 45 -
FNLDDTEVALLQAVLLMSSDRPG THB2_RAT 416 45 -
FSLDDTEVALLQAVLLMSSDRPG THB6_XENLA 275 45 -
FNLDDTEVALLQAVLLMSSDRTG THA_RANCA 317 45 -
Final Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
GYIPSYLDKDELCVV THB1_HUMAN 95 95 -
GYIPSYLDKDELCVV THB_RANCA 7 7 -
GYIPSYLDKDELCVV THB_CHICK 3 3 -
GYIPSYLDKDELCVV THB2_HUMAN 110 110 -
GYIPSYLDKDELCVV Q13986 90 90 -
GYIPSYLDKDELCVV THB1_MOUSE 95 95 -
GYIPSYLDKDELCVV THB1_RAT 95 95 -
GYIPSYLDKDELCVV THB2_MOUSE 109 109 -
GYIPSYLDKDELCVV THB2_RAT 148 148 -
GYIPSYLDKDELCVV THB7_XENLA 48 48 -
GYIPSYLDKDELCVV THB6_XENLA 7 7 -
GYIPSYLDKDEQCVV THA_CHICK 39 39 -
GYIPSYLDKDELCVV THB1_XENLA 3 3 -
GYIPSYLDKDELCVV THB5_XENLA 7 7 -
GYIPSYLDKDEPCVV Q91911 49 49 -
GYIPSYLTKDEPCVV THA_RANCA 49 49 -
GYIPSYLDKDEPCVV THAA_XENLA 49 49 -
GYIPSYLDKDEPCVV THAB_XENLA 49 49 -
GYIPSYLDKDEQCVV THA2_RAT 41 41 -
GYIPSYLDKDEQCVV THA1_SHEEP 41 41 -
GYIPSYLDKDEQCVV THA1_MOUSE 41 41 -
GYIPSYLDKDEQCVV THA2_HUMAN 41 41 -
GYIPSYLDKDEQCVV THA1_HUMAN 41 41 -
GYIPSCLDKDEQCVV ERBA_AVIER 25 25 -
GYIPSCLDKDEQCVV Q64895 57 57 -
GYVPSYLEKDEPCVV THA1_BRARE 45 45 -
GYIPSYLEKDEPCVV THAB_PAROL 21 21 -
GYIPSYLEKDEPCVV THAA_PAROL 47 47 -
GYIPSYLDKDELCVV THB_PAROL 20 20 -

Motif 2 width=12
Element Seqn Id St Int Rpt
RTIQKNLHPSYS THB1_HUMAN 133 23 -
RTIQKNLHPSYS THB_RANCA 45 23 -
RTIQKNLHPTYS THB_CHICK 41 23 -
RTIQKNLHPSYS THB2_HUMAN 148 23 -
RTIQKNLHPSYS Q13986 128 23 -
RTIQKSLHPSYS THB1_MOUSE 133 23 -
RTIQKSLHPSYS THB1_RAT 133 23 -
RTIQKSLHPSYS THB2_MOUSE 147 23 -
RTIQKSLHPSYS THB2_RAT 186 23 -
RTIQKNLHPSYS THB7_XENLA 86 23 -
RTIQKNLHPSYS THB6_XENLA 45 23 -
RTIQKNLHPTYS THA_CHICK 77 23 -
RTIQKNLHPSYS THB1_XENLA 41 23 -
RTIQKNLHPSYS THB5_XENLA 45 23 -
RTIQKNLHPSYS Q91911 87 23 -
RTIQKNLHPSYS THA_RANCA 87 23 -
RTIQKNLHPSYS THAA_XENLA 87 23 -
RTIQKNLHPSYS THAB_XENLA 87 23 -
RTIQKNLHPTYS THA2_RAT 79 23 -
RTIQKNLHPTYS THA1_SHEEP 79 23 -
RTIQKNLHPTYS THA1_MOUSE 79 23 -
RTIQKNLHPTYS THA2_HUMAN 79 23 -
RTIQKNLHPTYS THA1_HUMAN 79 23 -
RTIQKNLHPTYS ERBA_AVIER 63 23 -
RTIQKNLHPTYS Q64895 95 23 -
RTIQKNLHPSYS THA1_BRARE 83 23 -
RTIQKNLHPSYS THAB_PAROL 59 23 -
RTIQKNLHPSYS THAA_PAROL 85 23 -
RTIQKNLNPTYA THB_PAROL 58 23 -

Motif 3 width=17
Element Seqn Id St Int Rpt
VGMATDLVLDDSKRLAK THB1_HUMAN 172 27 -
VGMATDLVLDDSKRLAK THB_RANCA 84 27 -
VGMATDLVLDDSKRLAK THB_CHICK 80 27 -
VGMATDLVLDDSKRLAK THB2_HUMAN 187 27 -
VGMATDLVLDDSKRLAK Q13986 167 27 -
VGMATDLVLDDSKRLAK THB1_MOUSE 172 27 -
VGMATDLVLDDSKRLAK THB1_RAT 172 27 -
VGMATDLVLDDSKRLAK THB2_MOUSE 186 27 -
VGMATDLVLDDSKRLAK THB2_RAT 225 27 -
VGMATDLVLDDSKRLAK THB7_XENLA 125 27 -
VGMATDLVLDDSKRLAK THB6_XENLA 84 27 -
VGMAMDLVLDDSKRVAK THA_CHICK 116 27 -
VGMATDLVLDDNKRLAK THB1_XENLA 80 27 -
VGMATDLVLDDNKRLAK THB5_XENLA 84 27 -
VGMAMDLVLDDSKRVAK Q91911 126 27 -
VGMAMDLVLDDSKRVAK THA_RANCA 126 27 -
VGMAMDLVLDDGKRVAK THAA_XENLA 126 27 -
VGMAMDLDLDDSKRVAK THAB_XENLA 126 27 -
VGMAMDLVLDDSKRVAK THA2_RAT 118 27 -
VGMAMDLVLDDSKRVAK THA1_SHEEP 118 27 -
VGMAMDLVLDDSKRVAK THA1_MOUSE 118 27 -
VGMAMDLVLDDSKRVAK THA2_HUMAN 118 27 -
VGMAMDLVLDDSKRVAK THA1_HUMAN 118 27 -
VGMAMDLVLDDSKRVAK ERBA_AVIER 102 27 -
VGMAMDLVLDDSKRVAK Q64895 134 27 -
VGMAMDLVLDDSKRVAK THA1_BRARE 122 27 -
VGMAMDLVLDDSKRVAK THAB_PAROL 98 27 -
VGMAMDLVLDDSKRVAK THAA_PAROL 124 27 -
VGMATDLVLDDSKRLAK THB_PAROL 97 27 -

Motif 4 width=19
Element Seqn Id St Int Rpt
RKLIEENREKRRREELQKS THB1_HUMAN 189 0 -
RKLIEENREKRRKDELQKT THB_RANCA 101 0 -
RKLIEENREKRRREELQKT THB_CHICK 97 0 -
RKLIEENREKRRREELQKS THB2_HUMAN 204 0 -
RKLIEENREKRRREELQKS Q13986 184 0 -
RKLIEENREKRRREELQKS THB1_MOUSE 189 0 -
RKLIEENREKRRREELQKS THB1_RAT 189 0 -
RKLIEENREKRRREELQKS THB2_MOUSE 203 0 -
RKLIEENREKRRREELQKS THB2_RAT 242 0 -
RKLIEENREKRRKDEIQKS THB7_XENLA 142 0 -
RKLIEENREKRRKDEIQKS THB6_XENLA 101 0 -
RKLIEENRERRRKEEMIKS THA_CHICK 133 0 -
RKLIEENREKRRKDEIQKS THB1_XENLA 97 0 -
RKLIEENREKRRKDEIQKS THB5_XENLA 101 0 -
RKLIEENRVRRRKEEMIKT Q91911 143 0 -
RKLIEENRERRRKEEMIKT THA_RANCA 143 0 -
RKLIEENRQRRRKEEMIKT THAA_XENLA 143 0 -
RKLIEEDRVRRRKEEMIKT THAB_XENLA 143 0 -
RKLIEQNRERRRKEEMIRS THA2_RAT 135 0 -
RKLIEQNRERRRKEEMIRS THA1_SHEEP 135 0 -
RKLIEQNRERRRKEEMIRS THA1_MOUSE 135 0 -
RKLIEQNRERRRKEEMIRS THA2_HUMAN 135 0 -
RKLIEQNRERRRKEEMIRS THA1_HUMAN 135 0 -
RKLIEENRERRRKEEMIKS ERBA_AVIER 119 0 -
RKLIEENRERRRKEEMIKS Q64895 151 0 -
RRLIEENREKRKKEEIVKT THA1_BRARE 139 0 -
RRLIEENRERRKKEEIVKT THAB_PAROL 115 0 -
RRLIEENREKRKREEMVRT THAA_PAROL 141 0 -
RKLIEENRERRRKEELQKT THB_PAROL 114 0 -

Motif 5 width=18
Element Seqn Id St Int Rpt
PEPTDEEWELIKTVTEAH THB1_HUMAN 212 4 -
PEPTPEEWELIQVVTEAH THB_RANCA 124 4 -
PEPTDEEWELIKIVTEAH THB_CHICK 120 4 -
PEPTDEEWELIKTVTEAH THB2_HUMAN 227 4 -
PEPTDEEWELIKTVTEAH Q13986 207 4 -
PEPTDEEWELIKTVTEAH THB1_MOUSE 212 4 -
PEPTDEEWELIKTVTEAH THB1_RAT 212 4 -
PEPTDEEWELIKTVTEAH THB2_MOUSE 226 4 -
PEPTDEEWELIKTVTEAH THB2_RAT 265 4 -
PEPTQEEWELIQVVTEAH THB7_XENLA 165 4 -
PEPTQEEWELIQVVTEAH THB6_XENLA 124 4 -
PSPSAEEWELIHVVTEAH THA_CHICK 156 4 -
PEPTQEEWELIQVVTEAH THB1_XENLA 120 4 -
PEPTQEEWELIQVVTEAH THB5_XENLA 124 4 -
PEPSSEEWELIRIVTEAH Q91911 166 4 -
PEPSSEEWELIRIVTEAH THA_RANCA 166 4 -
PEPSSEEWELIRIVTEAH THAA_XENLA 166 4 -
PEPSSEEWELIRIVTEAH THAB_XENLA 166 4 -
PEPTPEEWDLIHVATEAH THA2_RAT 158 4 -
PEPTPEEWDLIHVATEAH THA1_SHEEP 158 4 -
PEPTPEEWDLIHVATEAH THA1_MOUSE 158 4 -
PEPTPEEWDLIHIATEAH THA2_HUMAN 158 4 -
PEPTPEEWDLIHIATEAH THA1_HUMAN 158 4 -
PSPSAEEWELIHVVTEAH ERBA_AVIER 142 4 -
PSPSAEEWELIHVVTEAH Q64895 174 4 -
PEPTVSEWELIRMVTEAH THA1_BRARE 162 4 -
PEPTGAEWELIRMVTEAH THAB_PAROL 138 4 -
PEPDTAEWELIRMATDAH THAA_PAROL 164 4 -
LEPTQEEWDLIRMVTEAH THB_PAROL 137 4 -

Motif 6 width=20
Element Seqn Id St Int Rpt
QGSHWKQKRKFLPEDIGQAP THB1_HUMAN 235 5 -
QGSHWKQKRKFLPEDIGQAP THB_RANCA 147 5 -
QGSHWKQKRKFLPEDIGQAP THB_CHICK 143 5 -
QGSHWKQKPKFLPEDIGQAP THB2_HUMAN 250 5 -
QGSHWKQKPKFLPEDIGQAP Q13986 230 5 -
QGSHWKQKRKFLPEDIGQAP THB1_MOUSE 235 5 -
QGSHWKQKRKFLPEDIGQAP THB1_RAT 235 5 -
QGSHWKQKRKFLPEDIGQAP THB2_MOUSE 249 5 -
QGSHWKQKRKFLPEDIGQAP THB2_RAT 288 5 -
QGSHWKQKRKFLPEDIGQAP THB7_XENLA 188 5 -
QGSHWKQKRKFLPEDIGQAP THB6_XENLA 147 5 -
QGSHWKQKRKFLPEDIGQSP THA_CHICK 179 5 -
QGSHWKQKRKFLPEDIGQAP THB1_XENLA 143 5 -
QGSHWKQKRKFLPEDIGQAP THB5_XENLA 147 5 -
QGSHWKQRRKFLPEDIGQSP Q91911 189 5 -
QGSHWKQRRKFLPEDIGQNP THA_RANCA 189 5 -
QGSHWKQRRKFLPEDIGQSP THAA_XENLA 189 5 -
QGSHWKQRRKFLPEDIGQSP THAB_XENLA 189 5 -
QGSHWKQRRKFLPDDIGQSP THA2_RAT 181 5 -
QGSHWKQRRKFLPDDIGQSP THA1_SHEEP 181 5 -
QGSHWKQRRKFLPDDIGQSP THA1_MOUSE 181 5 -
QGSHWKQRRKFLPDDIGQSP THA2_HUMAN 181 5 -
QGSHWKQRRKFLPDDIGQSP THA1_HUMAN 181 5 -
QGSHWKQRRKFLLEDIGQSP ERBA_AVIER 165 5 -
QGSHWKQRRKFLLEDIGQSP Q64895 197 5 -
QGPHWKQKRKFLPEDIGQSP THA1_BRARE 185 5 -
QGAQWKQKRKFLPDKIGQSP THAB_PAROL 161 5 -
QGSSWKQKRKFLSDDIGQSP THAA_PAROL 187 5 -
QGNHWKQKRKFLSAAGVKED THB_PAROL 160 5 -

Motif 7 width=22
Element Seqn Id St Int Rpt
FTKIITPAITRVVDFAKKLPMF THB1_HUMAN 272 17 -
FTKIITPAITRVVDFAKKLPMF THB_RANCA 184 17 -
FTKIITPAITRVVDFAKKLPMF THB_CHICK 180 17 -
FTKIITPAITRVVDFAKKLPMF THB2_HUMAN 287 17 -
FTKIITPAITRVVDFAKKLPMF Q13986 267 17 -
FTKIITPAITRVVDFAKKLPMF THB1_MOUSE 272 17 -
FTKIITPAITRVVDFAKKLPMF THB1_RAT 272 17 -
FTKIITPAITRVVDFAKKLPMF THB2_MOUSE 286 17 -
FTKIITPAITRVVDFAKKLPMF THB2_RAT 325 17 -
FTKIITPAITRVVDFAKKLPMF THB7_XENLA 225 17 -
FTKIITPAITRVVDFAKKLPMF THB6_XENLA 184 17 -
FTKIITPAITRVVDFAKKLPMF THA_CHICK 216 17 -
FTKIITPAITRVVDFAKKLPMF THB1_XENLA 180 17 -
FTKIITPAITRVVDFAKKLPMF THB5_XENLA 184 17 -
FTKIITPAITRVVDFAKKLPMF Q91911 226 17 -
FTKIITPAITRVVDFAKKLPMF THA_RANCA 226 17 -
FTKIITPAITRVVDFAKKLPMF THAA_XENLA 226 17 -
FTKIITPAITRVVDFAKKLPMF THAB_XENLA 226 17 -
FTKIITPAITRVVDFAKKLPMF THA2_RAT 218 17 -
FTKIITPAITRVVDFAKKLPMF THA1_SHEEP 218 17 -
FTKIITPAITRVVDFAKKLPMF THA1_MOUSE 218 17 -
FTKIITPAITRVVDFAKKLPMF THA2_HUMAN 218 17 -
FTKIITPAITRVVDFAKKLPMF THA1_HUMAN 218 17 -
FTKIITPAITRVVDFAKNLPMF ERBA_AVIER 202 17 -
FTKIITPAITRVVDFAKNLPMF Q64895 234 17 -
FTKIITPAITRVVDFAKKLPMF THA1_BRARE 221 16 -
FTKIITPAITRVVDFAKKLPMF THAB_PAROL 198 17 -
FTKIMTPAITRVVDFAKKLPMF THAA_PAROL 224 17 -
FTKIITPAITRVVDFAKKLPMF THB_PAROL 206 26 -

Motif 8 width=20
Element Seqn Id St Int Rpt
CEDQIILLKGCCMEIMSLRA THB1_HUMAN 298 4 -
CEDQIILLKGCCMEIMSLRA THB_RANCA 210 4 -
CEDQIILLKGCCMEIMSLRA THB_CHICK 206 4 -
CEDQIILLKGCCMEIMSLRA THB2_HUMAN 313 4 -
CEDQIILLKGCCMEIMSLRA Q13986 293 4 -
CEDQIILLKGCCMEIMSLRA THB1_MOUSE 298 4 -
CEDQIILLKGCCMEIMSLRA THB1_RAT 298 4 -
CEDQIILLKGCCMEIMSLRA THB2_MOUSE 312 4 -
CEDQIILLKGCCMEIMSLRA THB2_RAT 351 4 -
CEDQIILLKGCCMEIMSLRA THB7_XENLA 251 4 -
CEDQIILLKGCCMEIMSLRA THB6_XENLA 210 4 -
CEDQIILLKGCCMEIMSLRA THA_CHICK 242 4 -
CEDQIILLKGCCMEIMSLRA THB1_XENLA 206 4 -
CEDQIILLKGCCMEIMSLRA THB5_XENLA 210 4 -
CEDQIILLKGCCMEIMSLRA Q91911 252 4 -
CEDQIILLKGCCMEIMSLRA THA_RANCA 252 4 -
CEDQIILLKGCCMEIMSLRA THAA_XENLA 252 4 -
CEDQIILLKGCCMEIMSLRA THAB_XENLA 252 4 -
CEDQIILLKGCCMEIMSLRA THA2_RAT 244 4 -
CEDQIILLKGCCMEIMSLRA THA1_SHEEP 244 4 -
CEDQIILLKGCCMEIMSLRA THA1_MOUSE 244 4 -
CEDQIILLKGCCMEIMSLRA THA2_HUMAN 244 4 -
CEDQIILLKGCCMEIMSLRA THA1_HUMAN 244 4 -
CEDQIILLKGCCMEIMSLRA ERBA_AVIER 228 4 -
CEDQIILLKGCCMEIMSLRA Q64895 260 4 -
CEDQIILLKGCCMEIMSLRA THA1_BRARE 247 4 -
CEDQIILLKGCCMEIMSLRA THAB_PAROL 225 5 -
CEDQIILLKGCCMEIMSLRA THAA_PAROL 250 4 -
CEDQIILLKGCCMEIMSLRA THB_PAROL 232 4 -

Motif 9 width=23
Element Seqn Id St Int Rpt
FNLDDTEVALLQAVLLMSSDRPG THB1_HUMAN 363 45 -
FNLDDTEVALLQAVLLMSSDRPG THB_RANCA 275 45 -
FNLDDTEVALLQAVLLMSSDRPG THB_CHICK 271 45 -
FNLDDTEVALLQAVLLMSSDRPG THB2_HUMAN 378 45 -
FNLDDTEVALLQAVLLMSSDRPG Q13986 358 45 -
FNLDDTEVALLQAVLLMSSDRPG THB1_MOUSE 363 45 -
FNLDDTEVALLQAVLLMSSDRPG THB1_RAT 363 45 -
FNLDDTEVALLQAVLLMSSDRPG THB2_MOUSE 377 45 -
FNLDDTEVALLQAVLLMSSDRPG THB2_RAT 416 45 -
FSLDDTEVALLQAVLLMSSDRPG THB7_XENLA 316 45 -
FSLDDTEVALLQAVLLMSSDRPG THB6_XENLA 275 45 -
FNLDDTEVALLQAVLLMSSDRTG THA_CHICK 307 45 -
FSLDDTEVALLQAVLLMSSDRPG THB1_XENLA 271 45 -
FSLDDTEVALLQAVLLMSSDRPG THB5_XENLA 275 45 -
FNLDDTEVALLQAVLLMSSDRTG Q91911 317 45 -
FNLDDTEVALLQAVLLMSSDRTG THA_RANCA 317 45 -
FNLDDTEVALLQAVLLMSSDRTG THAA_XENLA 317 45 -
FNLDDTEVALLQAVLLMSSDRTG THAB_XENLA 317 45 -
FNLDDTEVALLQAVLLMSTDRSG THA2_RAT 309 45 -
FNLDDTEVALLQAVLLMSTDRSG THA1_SHEEP 309 45 -
FNLDDTEVALLQAVLLMSTDRSG THA1_MOUSE 309 45 -
FNLDDTEVALLQAVLLMSTDRSG THA2_HUMAN 309 45 -
FNLDDTEVALLQAVLLMSTDRSG THA1_HUMAN 309 45 -
FNLDDTEVALLQAVLLMSSDRTG ERBA_AVIER 293 45 -
FNLDDTEVALLQAVLLMSSDRTG Q64895 325 45 -
FNLDDSEVALLQAVLLMSSDRSG THA1_BRARE 312 45 -
FNLDDTEVALLQAVLLMSSDRSG THAB_PAROL 290 45 -
FNLDDTEVALMQAVLLMSSDRSG THAA_PAROL 315 45 -
FNLDDSEVALLQAVILLSSDRPG THB_PAROL 297 45 -