SPRINT Home UMBER Home Contents Standard Search Advanced Search Relation Search

==SPRINT==> PRINTS View



  selected as


PR00534

Identifier
MCRFAMILY  [View Relations]  [View Alignment]  
Accession
PR00534
No. of Motifs
7
Creation Date
20-MAY-1996  (UPDATE 07-JUN-1999)
Title
Melanocortin receptor family signature
Database References
PRINTS; PR90007 7TM; PR90006 GPCRCLAN; PR00237 GPCRRHODOPSN
PRINTS; PR00520 ACTROPHINR; PR00535 MELNOCORTINR; PR00536 MELNOCYTESHR

INTERPRO; IPR001671
Literature References
1. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994).
 
2. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
G protein-coupled receptor fingerprints.
7TM, VOLUME 2, EDS. G.VRIEND AND B.BYWATER (1993).
 
3. BIRNBAUMER, L.
G proteins in signal transduction.
ANNU.REV.PHARMACOL.TOXICOL. 30 675-705 (1990).
 
4. CASEY, P.J. AND GILMAN, A.G.
G protein involvement in receptor-effector coupling.
J.BIOL.CHEM. 263(6) 2577-2580 (1988).
 
5. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Design of a discriminating fingerprint for G protein-coupled receptors.
PROTEIN ENG. 6(2) 167-176 (1993).
 
6. WATSON, S. AND ARKINSTALL, S.
Melanocortins.
IN THE G PROTEIN-LINKED RECEPTOR FACTSBOOK, ACADEMIC PRESS, 1994, PP.180-191.

Documentation
G protein-coupled receptors (GPCRs) constitute a vast protein family that 
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the 
sequence level, on the basis of which they can be separated into distinct 
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship, 
but between which there is no statistically significant similarity in 
sequence [1]. The currently known clan members include the rhodopsin-like 
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
 
The rhodopsin-like GPCRs themselves represent a widespread protein family 
that includes hormone, neurotransmitter and light receptors, all of
which transduce extracellular signals through interaction with guanine
nucleotide-binding (G) proteins. Although their activating ligands vary 
widely in structure and character, the amino acid sequences of the 
receptors are very similar and are believed to adopt a common structural 
framework comprising 7 transmembrane (TM) helices [3-5]. 
 
Adrenocorticotrophin (ACTH), melanocyte-stimulating hormones (MSH) and
beta-endorphin are peptide products of pituitary pro-opiomelanocortin.
ACTH regulates synthesis and release of glucocorticoids and aldosterone
in the adrenal cortex; it also has a trophic action on these cells [6]. 
ACTH and beta-endorphin are synthesised and released in response to 
corticotrophin-releasing factor at times of stress (heat, cold, infections,
etc.) - their release leads to increased metabolism and analgesia res..
MSH has a trophic action on melanocytes, and regulates pigment production
in fish and amphibia [6]. The ACTH receptor is found in high levels in
the adrenal cortex - binding sites are present in lower levels in the
CNS. The MSH receptor is expressed in high levels in melanocytes, 
melanomas and their derived cell lines [6]. Receptors are found in low
levels in the CNS. MSH regulates temperature control in the septal region
of the brain and releases prolactin from the pituitary.
 
MCRFAMILY is a 7-element fingerprint that provides a signature for the
melanocortin receptors. The fingerprint was derived from an initial
alignment of 6 sequences: the motifs were drawn from conserved sections   
within either loop or TM regions, focusing on those areas of the 
alignment that characterise the melanocortin receptors but distinguish them
from the rest of the rhodopsin-like superfamily - motif 1 spans the first
cytoplasmic loop; motif 2 spans part of the first external loop leading
into TM domain 3; motif 3 lies in the second cytoplasmic loop; motif 4
encodes the N-terminus of TM domain 6; motif 5 lies in the third external
loop; motif 6 was drawn from the N-terminus of TM domain 7; and motif 7
resides in the C-terminal region following TM domain 7. Two iterations on
OWL27.1 were required to reach convergence, at which point a true set
comprising 20 sequences was identfied. Several partial matches were also
found: those matching 4 or 5 motifs are largely melanocortin receptor
fragments; while those matching just 2 motifs are members of the wider
rhodopsin-like superfamily.
 
An update on SPTR37_9f identified a true set of 32 sequences.
Summary Information
32 codes involving  7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
732323232323232
60000000
50000000
40000000
30000000
20000000
1234567
True Positives
ACTR_BOVIN    ACTR_HUMAN    ACTR_MESAU    ACTR_MOUSE    
MC3R_HUMAN MC3R_MOUSE MC3R_RAT MC4R_HUMAN
MC4R_RAT MC5R_BOVIN MC5R_HUMAN MC5R_MOUSE
MC5R_RAT MC5R_SHEEP MSHR_ALCAA MSHR_BOVIN
MSHR_CAPCA MSHR_CAPHI MSHR_CEREL MSHR_CHICK
MSHR_DAMDA MSHR_HUMAN MSHR_MOUSE MSHR_OVIMO
MSHR_RANTA MSHR_SHEEP MSHR_VULVU O57317
O73667 O73671 O77616 O93259
Sequence Titles
ACTR_BOVIN  ADRENOCORTICOTROPIC HORMONE RECEPTOR (ACTH-R) (MELANOCORTIN-2 RECEPTOR) (MC2-R) (ADRENOCORTICOTROPIN RECEPTOR) - BOS TAURUS (BOVINE). 
ACTR_HUMAN ADRENOCORTICOTROPIC HORMONE RECEPTOR (ACTH-R) (MELANOCORTIN-2 RECEPTOR) (MC2-R) (ADRENOCORTICOTROPIN RECEPTOR) - HOMO SAPIENS (HUMAN).
ACTR_MESAU ADRENOCORTICOTROPIC HORMONE RECEPTOR (ACTH-R) (MELANOCORTIN-2 RECEPTOR) (MC2-R) (ADRENOCORTICOTROPIN RECEPTOR) - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
ACTR_MOUSE ADRENOCORTICOTROPIC HORMONE RECEPTOR (ACTH-R) (MELANOCORTIN-2 RECEPTOR) (MC2-R) (ADRENOCORTICOTROPIN RECEPTOR) - MUS MUSCULUS (MOUSE).
MC3R_HUMAN Melanocortin receptor 3 (MC3-R) - Homo sapiens (Human).
MC3R_MOUSE Melanocortin receptor 3 (MC3-R) - Mus musculus (Mouse).
MC3R_RAT Melanocortin receptor 3 (MC3-R) - Rattus norvegicus (Rat).
MC4R_HUMAN Melanocortin receptor 4 (MC4-R) - Homo sapiens (Human).
MC4R_RAT Melanocortin receptor 4 (MC4-R) - Rattus norvegicus (Rat).
MC5R_BOVIN Melanocortin receptor 5 (MC5-R) - Bos taurus (Bovine).
MC5R_HUMAN Melanocortin receptor 5 (MC5-R) (MC-2) - Homo sapiens (Human).
MC5R_MOUSE Melanocortin receptor 5 (MC5-R) - Mus musculus (Mouse).
MC5R_RAT Melanocortin receptor 5 (MC5-R) - Rattus norvegicus (Rat).
MC5R_SHEEP Melanocortin receptor 5 (MC5-R) - Ovis aries (Sheep).
MSHR_ALCAA Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R) - Alces alces alces (European moose) (Elk).
MSHR_BOVIN Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R) (BDF3) - Bos taurus (Bovine).
MSHR_CAPCA Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R) - Capreolus capreolus (Roe deer).
MSHR_CAPHI Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R) - Capra hircus (Goat).
MSHR_CEREL Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R) - Cervus elaphus (Red deer).
MSHR_CHICK Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R) - Gallus gallus (Chicken).
MSHR_DAMDA Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R) - Dama dama (Fallow deer) (Cervus dama).
MSHR_HUMAN Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R) - Homo sapiens (Human).
MSHR_MOUSE Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R) - Mus musculus (Mouse).
MSHR_OVIMO Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R) - Ovibos moschatus (Muskox).
MSHR_RANTA Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R) - Rangifer tarandus (Reindeer) (Caribou).
MSHR_SHEEP Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R) - Ovis aries (Sheep).
MSHR_VULVU Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R) - Vulpes vulpes (Red fox).
O57317 MELANOCORTIN 2-RECEPTOR - GALLUS GALLUS (CHICKEN).
O73667 MELANOCORTIN 4-RECEPTOR - GALLUS GALLUS (CHICKEN).
O73671 MELANOCORTIN 5-RECEPTOR - GALLUS GALLUS (CHICKEN).
O77616 MELANOCORTIN 1 RECEPTOR - CANIS FAMILIARIS (DOG).
O93259 MELANOCORTIN 3-RECEPTOR - GALLUS GALLUS (CHICKEN).
Scan History
OWL27_1    2  100  NSINGLE    
SPTR37_9f 2 33 NSINGLE
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
KNKNLHSPMYFFI MC4R_HUMAN 71 71 -
KNRNLHSPMYCFI MSHR_HUMAN 65 65 -
RNGNLHSPMYFFL MC3R_HUMAN 102 102 -
KNKNLHSPMYFFV MC5R_HUMAN 63 63 -
KNKNLQAPMYFFI ACTR_HUMAN 51 51 -
KNKSLQSPMYFFI ACTR_BOVIN 51 51 -

Motif 2 width=15
Element Seqn Id St Int Rpt
DNVIDSVICSSLLAS MC4R_HUMAN 122 38 -
DNVIDVITCSSMLSS MSHR_HUMAN 117 39 -
DNIFDSMICISLVAS MC3R_HUMAN 154 39 -
DNVFDSMICISVVAS MC5R_HUMAN 115 39 -
DDIIDSLFVLSLLGS ACTR_HUMAN 103 39 -
DDVVDSLFILSLLGS ACTR_BOVIN 103 39 -

Motif 3 width=12
Element Seqn Id St Int Rpt
IFYALQYHNIMT MC4R_HUMAN 151 14 -
IFYALRYHSIVT MSHR_HUMAN 146 14 -
IFYALRYHSIMT MC3R_HUMAN 183 14 -
IFYALRYHHIMT MC5R_HUMAN 144 14 -
IFHALRYHSIVT ACTR_HUMAN 132 14 -
IFHALQYHRIMT ACTR_BOVIN 132 14 -

Motif 4 width=13
Element Seqn Id St Int Rpt
KGAITLTILIGVF MC4R_HUMAN 242 79 -
KGAVTLTILLGIF MSHR_HUMAN 238 80 -
KGAVTITILLGVF MC3R_HUMAN 276 81 -
QGAVTVTMLLGVF MC5R_HUMAN 235 79 -
KGAITLTILLGVF ACTR_HUMAN 216 72 -
RGAVTLTVLLGVF ACTR_BOVIN 216 72 -

Motif 5 width=18
Element Seqn Id St Int Rpt
FYISCPQNPYCVCFMSHF MC4R_HUMAN 267 12 -
LIVLCPEHPTCGCIFKNF MSHR_HUMAN 263 12 -
LIITCPTNPYCICYTAHF MC3R_HUMAN 301 12 -
LMLSCPQNLYCSRFMSHF MC5R_HUMAN 260 12 -
LMTFCPSNPYCACYMSLF ACTR_HUMAN 241 12 -
LMTFCPADPYCACYMSLF ACTR_BOVIN 241 12 -

Motif 6 width=12
Element Seqn Id St Int Rpt
LIMCNSIIDPLI MC4R_HUMAN 290 5 -
LIICNAIIDPLI MSHR_HUMAN 286 5 -
LIMCNSVIDPLI MC3R_HUMAN 324 5 -
LIMCNSVMDPLI MC5R_HUMAN 283 5 -
LIMCNAVIDPFI ACTR_HUMAN 264 5 -
LIMCNAIIDPFI ACTR_BOVIN 264 5 -

Motif 7 width=14
Element Seqn Id St Int Rpt
SQELRKTFKEIICC MC4R_HUMAN 306 4 -
SQELRRTLKEVLTC MSHR_HUMAN 302 4 -
SLELRNTFREILCG MC3R_HUMAN 340 4 -
SQEMRKTFKEIICC MC5R_HUMAN 299 4 -
SPELRDAFKKMIFC ACTR_HUMAN 280 4 -
SPELRVAFKKMVIC ACTR_BOVIN 280 4 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
KNRNLHSPMYYFI MSHR_ALCAA 65 65 -
KNRNLHSPMYYFI MSHR_BOVIN 65 65 -
KNRNLHSPMYYFI MSHR_DAMDA 65 65 -
KNRNLHSPMYYFI MSHR_CAPHI 65 65 -
KNRNLHSPMYYFI MSHR_SHEEP 65 65 -
KNRNLHSPMYYFI MSHR_CAPCA 65 65 -
KNSNLHSPMYYFI MSHR_RANTA 65 65 -
KNRNLHSPMYYFV MSHR_OVIMO 65 65 -
KNRNLQSPMYYFI MSHR_CEREL 65 65 -
KNKNLHSPMYFFV O73671 63 63 -
KNKNLHSPMYFFI MC4R_HUMAN 71 71 -
KNRNLHSPMYYFI MSHR_VULVU 65 65 -
KNRNLHSPMYYFI O77616 65 65 -
KNKNLHSPMYFFI O73667 70 70 -
KNRNLHSPMYCFI MSHR_HUMAN 65 65 -
KNGNLHSPMYFFL O93259 65 65 -
KNKNLHSPMYFFI MC4R_RAT 71 71 -
KNKNLHSPMYFFV MC5R_MOUSE 63 63 -
KNKNLHSPMYFFV MC5R_RAT 63 63 -
KNRNLHSPTYYFI MSHR_CHICK 63 63 -
KNRNLHSPMYYFI MSHR_MOUSE 63 63 -
RNGNLHSPMYFFL MC3R_MOUSE 65 65 -
RNGNLHSPMYFFL MC3R_RAT 65 65 -
RNGNLHSPMYFFL MC3R_HUMAN 102 102 -
KNKNLHSPMYFFV MC5R_HUMAN 63 63 -
RNRNLHTPMYFFV MC5R_BOVIN 63 63 -
RNRNLHIPMYFFV MC5R_SHEEP 63 63 -
KNKNLQAPMYFFI ACTR_HUMAN 51 51 -
KNKNLQSPMYFFI ACTR_MOUSE 51 51 -
RNKNLHLPMYFFI O57317 66 66 -
KNKNLQCPMYFFI ACTR_MESAU 51 51 -
KNKSLQSPMYFFI ACTR_BOVIN 51 51 -

Motif 2 width=15
Element Seqn Id St Int Rpt
DNVIDVLICGSMVSS MSHR_ALCAA 117 39 -
DNVIDVLICGSMVSS MSHR_BOVIN 117 39 -
DNVIDVLICGSMVSS MSHR_DAMDA 117 39 -
DNVIDVLICSSMVSS MSHR_CAPHI 117 39 -
DNVIDVLICSSMVSS MSHR_SHEEP 117 39 -
DNVIDMLICGSMVSS MSHR_CAPCA 117 39 -
DNVIDVLICGSMVSS MSHR_RANTA 117 39 -
DNVIDVLICSSMVSS MSHR_OVIMO 117 39 -
DNVIDVLICGSMVSS MSHR_CEREL 117 39 -
DNVFDSLICISVVAS O73671 115 39 -
DNVIDSVICSSLLAS MC4R_HUMAN 122 38 -
DDIIDVLICGSMVSS MSHR_VULVU 117 39 -
DDIIDVLICGSMVSS O77616 117 39 -
DNVIDSVICSSLLAS O73667 121 38 -
DNVIDVITCSSMLSS MSHR_HUMAN 117 39 -
DNVFDSMICISLVAS O93259 117 39 -
DNVIDSVICSSLLAS MC4R_RAT 122 38 -
DNVFDSMICISVVAS MC5R_MOUSE 115 39 -
DNVFDSMICISVVAS MC5R_RAT 115 39 -
DNVIDMLICSSVVSS MSHR_CHICK 115 39 -
DNLIDVLICGSMVSS MSHR_MOUSE 115 39 -
DNIFDSMICISLVAS MC3R_MOUSE 117 39 -
DNIFDSMICISLVAS MC3R_RAT 117 39 -
DNIFDSMICISLVAS MC3R_HUMAN 154 39 -
DNVFDSMICISVVAS MC5R_HUMAN 115 39 -
DNVFDSMICISVVAS MC5R_BOVIN 115 39 -
DNVFDSMICISVVAS MC5R_SHEEP 115 39 -
DDIIDSLFVLSLLGS ACTR_HUMAN 103 39 -
DDIIDCMFILSLLGS ACTR_MOUSE 103 39 -
DDAMDSMFILSLLGS O57317 118 39 -
DDIIDCMFILSLLGS ACTR_MESAU 103 39 -
DDVVDSLFILSLLGS ACTR_BOVIN 103 39 -

Motif 3 width=12
Element Seqn Id St Int Rpt
IFYALRYHSVVT MSHR_ALCAA 146 14 -
IFYALRYHSVVT MSHR_BOVIN 146 14 -
IFYALRYHSVVT MSHR_DAMDA 146 14 -
IFYALRYHSVVT MSHR_CAPHI 146 14 -
IFYALRYHSVVT MSHR_SHEEP 146 14 -
IFYALRYHSVVT MSHR_CAPCA 146 14 -
IFYALRYHSVVT MSHR_RANTA 146 14 -
IFYALRYHSVVT MSHR_OVIMO 146 14 -
IFYALRYHSVVT MSHR_CEREL 146 14 -
IFYALRYHNIMT O73671 144 14 -
IFYALQYHNIMT MC4R_HUMAN 151 14 -
IFYALRYHSIVT MSHR_VULVU 146 14 -
IFYALRYHSIVT O77616 146 14 -
IFYALQYHNIMT O73667 150 14 -
IFYALRYHSIVT MSHR_HUMAN 146 14 -
IFYALLYHSIMT O93259 146 14 -
IFYALQYHNIMT MC4R_RAT 151 14 -
IFYALRYHHIMT MC5R_MOUSE 144 14 -
IFYALRYHHIMT MC5R_RAT 144 14 -
IFYALRYHSIMT MSHR_CHICK 144 14 -
IFYALRYHSIVT MSHR_MOUSE 144 14 -
IFYALRYHSIMT MC3R_MOUSE 146 14 -
IFYALRYHSIMT MC3R_RAT 146 14 -
IFYALRYHSIMT MC3R_HUMAN 183 14 -
IFYALRYHHIMT MC5R_HUMAN 144 14 -
IFCALRYQRIMT MC5R_BOVIN 144 14 -
IFCRLRYQRIMT MC5R_SHEEP 144 14 -
IFHALRYHSIVT ACTR_HUMAN 132 14 -
IFHALQYHSIVT ACTR_MOUSE 132 14 -
IFYALRYHNIMT O57317 147 14 -
IFHALQYHSIVT ACTR_MESAU 132 14 -
IFHALQYHRIMT ACTR_BOVIN 132 14 -

Motif 4 width=13
Element Seqn Id St Int Rpt
KGAATLTILLGVF MSHR_ALCAA 238 80 -
KGAATLTILLGVF MSHR_BOVIN 238 80 -
KGAATLTILLGVF MSHR_DAMDA 238 80 -
KGAATLTILLGVF MSHR_CAPHI 238 80 -
KGAATLTILLGVF MSHR_SHEEP 238 80 -
KGAATLTILLGVF MSHR_CAPCA 238 80 -
KGAATLTILLGVF MSHR_RANTA 238 80 -
KGAATLTILLGVF MSHR_OVIMO 238 80 -
KGAATLTILLGVF MSHR_CEREL 238 80 -
KGAITLTMLLGIF O73671 235 79 -
KGAITLTILIGVF MC4R_HUMAN 242 79 -
KGAATLTILLGIF MSHR_VULVU 238 80 -
KGAATLTILLGIF O77616 238 80 -
KGAITLTILIGVF O73667 241 79 -
KGAVTLTILLGIF MSHR_HUMAN 238 80 -
KGAITITILLGVF O93259 237 79 -
KGAITLTILIGVF MC4R_RAT 242 79 -
KGAITLTMLLGIF MC5R_MOUSE 235 79 -
KGAITLTMLLGIF MC5R_RAT 235 79 -
KGAVTLTILLGVF MSHR_CHICK 235 79 -
KGAATLTILLGIF MSHR_MOUSE 236 80 -
KGAVTITILLGVF MC3R_MOUSE 239 81 -
KGAVTITILLGVF MC3R_RAT 239 81 -
KGAVTITILLGVF MC3R_HUMAN 276 81 -
QGAVTVTMLLGVF MC5R_HUMAN 235 79 -
KGAITLAMLLGVF MC5R_BOVIN 235 79 -
KGAITLAMLLGVF MC5R_SHEEP 235 79 -
KGAITLTILLGVF ACTR_HUMAN 216 72 -
KGAMTLTILLGVF ACTR_MOUSE 216 72 -
KGAITLTIFLGVF O57317 237 78 -
KGAITLTILLGVF ACTR_MESAU 216 72 -
RGAVTLTVLLGVF ACTR_BOVIN 216 72 -

Motif 5 width=18
Element Seqn Id St Int Rpt
LIVLCPQHPTCGCIFKNF MSHR_ALCAA 263 12 -
LIVLCPQHPTCGCIFKNF MSHR_BOVIN 263 12 -
LIVLCPQHPTCGCIFKNF MSHR_DAMDA 263 12 -
LIVLCPQHPTCGCIFKNF MSHR_CAPHI 263 12 -
LIVLCPQHPTCGCIFKNF MSHR_SHEEP 263 12 -
LIVLCPQHPTCGCIFKNF MSHR_CAPCA 263 12 -
LIVLCPQHPTCGCIFKNF MSHR_RANTA 263 12 -
LIVLCPQHPTCGCIFKNF MSHR_OVIMO 263 12 -
LIVLCPQHPTCGCIFKNF MSHR_CEREL 263 12 -
LMISCPQNLYCVCFMSHF O73671 260 12 -
FYISCPQNPYCVCFMSHF MC4R_HUMAN 267 12 -
LMVLCPQHPICGCVFQNF MSHR_VULVU 263 12 -
LMVLCPQHPICGCVFQNF O77616 263 12 -
FYISCPYNPYCVCFMSHF O73667 266 12 -
LIVLCPEHPTCGCIFKNF MSHR_HUMAN 263 12 -
LIISCPMNPYCVCYTSHF O93259 262 12 -
FYISCPQNPYCVCFMSHF MC4R_RAT 267 12 -
LMISCPQNVYCSCFMSYF MC5R_MOUSE 260 12 -
LMISCPQNVYCACFMSYF MC5R_RAT 260 12 -
LIVTCPTNPFCTCFFSYF MSHR_CHICK 260 12 -
LIVLCPQHPTCSCIFKNF MSHR_MOUSE 261 12 -
LIITCPTNPYCICYTAHF MC3R_MOUSE 264 12 -
LIITCPTNPYCICYTAHF MC3R_RAT 264 12 -
LIITCPTNPYCICYTAHF MC3R_HUMAN 301 12 -
LMLSCPQNLYCSRFMSHF MC5R_HUMAN 260 12 -
LMISCPHNLYCSCFMSHF MC5R_BOVIN 260 12 -
LMISCPQNLYCSCFMSHF MC5R_SHEEP 260 12 -
LMTFCPSNPYCACYMSLF ACTR_HUMAN 241 12 -
LMTFCPNNPYCVCYMSLF ACTR_MOUSE 241 12 -
LARFCPHNPYCACYMSIF O57317 262 12 -
LMTFCPNNPYCVCYMSLF ACTR_MESAU 241 12 -
LMTFCPADPYCACYMSLF ACTR_BOVIN 241 12 -

Motif 6 width=12
Element Seqn Id St Int Rpt
LIICNAIVDPLI MSHR_ALCAA 286 5 -
LIICNAIVDPLI MSHR_BOVIN 286 5 -
LIICNAIVDPLI MSHR_DAMDA 286 5 -
LIICNAIVDPLI MSHR_CAPHI 286 5 -
LIICNAIVDPLI MSHR_SHEEP 286 5 -
LIICNAIVDPLI MSHR_CAPCA 286 5 -
LIICNAIVDPLI MSHR_RANTA 286 5 -
LIICNAIVDPLI MSHR_OVIMO 286 5 -
LIICNAIVDPLI MSHR_CEREL 286 5 -
LIMCNSVIDPLI O73671 283 5 -
LIMCNSIIDPLI MC4R_HUMAN 290 5 -
LIICNSIIDPFI MSHR_VULVU 286 5 -
LIICNSIIDPFI O77616 286 5 -
LIMCNSIIDPLI O73667 289 5 -
LIICNAIIDPLI MSHR_HUMAN 286 5 -
LIMCNSVIDPLI O93259 285 5 -
LIMCNAVIDPLI MC4R_RAT 290 5 -
LIMCNSVIDPLI MC5R_MOUSE 283 5 -
LIMCNSVIDPLI MC5R_RAT 283 5 -
LIICNSVVDPLI MSHR_CHICK 283 5 -
LIVLSSTVDPLI MSHR_MOUSE 284 5 -
LIMCNSVIDPLI MC3R_MOUSE 287 5 -
LIMCNSVIDPLI MC3R_RAT 287 5 -
LIMCNSVIDPLI MC3R_HUMAN 324 5 -
LIMCNSVMDPLI MC5R_HUMAN 283 5 -
LIMCNSVIDPLI MC5R_BOVIN 283 5 -
LIMCNSVIDPLI MC5R_SHEEP 283 5 -
LIMCNAVIDPFI ACTR_HUMAN 264 5 -
LIMCNAVIDPFI ACTR_MOUSE 264 5 -
LIMCNAIIDPMI O57317 285 5 -
LIMCNAVIDPFI ACTR_MESAU 264 5 -
LIMCNAIIDPFI ACTR_BOVIN 264 5 -

Motif 7 width=14
Element Seqn Id St Int Rpt
SQELRKTLQEVLQC MSHR_ALCAA 302 4 -
SQELRKTLQEVLQC MSHR_BOVIN 302 4 -
SQELRKTLQEVLQC MSHR_DAMDA 302 4 -
SQELRKTLQEVLQC MSHR_CAPHI 302 4 -
SQELRKTLQEVLQC MSHR_SHEEP 302 4 -
SQELRKTLQEVLQC MSHR_CAPCA 302 4 -
SQELRKTLQEVLQC MSHR_RANTA 302 4 -
SQELRKTLQEVLQC MSHR_OVIMO 302 4 -
SQELRKTLQEVLQC MSHR_CEREL 302 4 -
SQEMRKTFKEIICC O73671 299 4 -
SQELRKTFKEIICC MC4R_HUMAN 306 4 -
SQELRKTLQEVVLC MSHR_VULVU 302 4 -
SQELRKTLQEVVLC O77616 302 4 -
SQELRKTFKEIICC O73667 305 4 -
SQELRRTLKEVLTC MSHR_HUMAN 302 4 -
SLEMRKTFKEIVCC O93259 301 4 -
SQELRKTFKEIICF MC4R_RAT 306 4 -
SQEMRRTFKEIVCC MC5R_MOUSE 299 4 -
SQEMRRTFKEIICC MC5R_RAT 299 4 -
SQELRRTLREVVLC MSHR_CHICK 299 4 -
SQELRMTLKEVLLC MSHR_MOUSE 300 4 -
SLELRNTFKEILCG MC3R_MOUSE 303 4 -
SLELRNTFKEILCG MC3R_RAT 303 4 -
SLELRNTFREILCG MC3R_HUMAN 340 4 -
SQEMRKTFKEIICC MC5R_HUMAN 299 4 -
SQEMRKTFKEIVCF MC5R_BOVIN 299 4 -
SQEMRKTFKEIVCF MC5R_SHEEP 299 4 -
SPELRDAFKKMIFC ACTR_HUMAN 280 4 -
SPELRDAFKRMLFC ACTR_MOUSE 280 4 -
SPELRSTFKKMFCC O57317 301 4 -
SPELRDAFKKMFSC ACTR_MESAU 280 4 -
SPELRVAFKKMVIC ACTR_BOVIN 280 4 -