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PR00437

Identifier
SMALLCYTKCXC  [View Relations]  [View Alignment]  
Accession
PR00437
No. of Motifs
3
Creation Date
18-DEC-1995  (UPDATE 25-JUN-1999)
Title
Small CXC cytokine family signature
Database References
PRINTS; PR00436 INTERLEUKIN8
PROSITE; PS00471 SMALL_CYTOKINES_CXC
PFAM; PF00048 il8
INTERPRO; IPR001089
PDB; 1PLF
SCOP; 1PLF
Literature References
1. CLORE, G.M., APPELLA, E., YAMADA, M., MATSUSHIMA, K. AND GRONENBORN, A.M.
Three-dimensional structure of interleukin 8 in solution.
BIOCHEMISTRY 29 1689-1696 (1990).
 
2. STUCKEY, J.A., ST. CHARLES, R. AND EDWARDS, B.F.
A model of the platelet factor 4 complex with heparin.
PROTEINS 14 277-287 (1992).
 
3. BAGGIOLINI, M. AND CLARK-LEWIS, I.
Interleukin-8, a chemotactic and inflammatory cytokine.
FEBS LETT. 307 97-101 (1992).

Documentation
Certain cell types, such as fibroblasts, endothelial cells and macrophages,
secrete low molecular weight proteins in response to a variety of stimuli,
including viral transformation, interferons and growth factors [1-3]. Some
of these factors are structurally related, existing as either homodimers or
homotetramers: each monomer has a core fold comprising a 3-stranded anti-
parallel beta-sheet in a Greek-key arrangement [2], and a C-terminal alpha-
helix [1,2]. The structure is held together by 2 disulphide bridges [1,2].
 
All such cytokine proteins possess mitogenic, chemotactic or inflammatory
activities [1-3], and are referred to as chemokines or intercrines. The
family can be split into 2 groups, depending on the spacing of 2 N-terminal
Cys residues [1,2]: in one group (CxC), the cysteines are separated by a
single amino acid; in the second (CC), they are adjacent [1,2]. The CxC 
group includes such factors as interleukin-8, platelet factor 4, melanoma 
growth stimulatory activity protein, macrophage inflammatory protein 2, 
platelet basic protein, and several others.
 
SMALLCYTKCXC is a 3-element fingerprint that provides a signature for the
CxC family of chemokines. The fingerprint was derived from an initial 
alignment of 16 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length - motif 1 encodes the N-
terminal region containing the first 2 cysteines; motif 2 spans the first
2 beta-strands; and motif 3 spans the third strand and part of the C-
terminal helix (the motifs encompass the region encoded by PROSITE pattern
SMALL_CYTOKINES_CXC (PS00471), which describes a large portion of the active
protein). Two iterations on OWL26.3 were required to reach convergence, at
which point a true set comprising 49 sequences was identified.
 
An update on SPTR37_9f identified a true set of 48 sequences, and 1
partial match.
Summary Information
  48 codes involving  3 elements
1 codes involving 2 elements
Composite Feature Index
3484848
2011
123
True Positives
AMC2_PIG      EMF1_CHICK    EN78_HUMAN    GCP2_BOVIN    
GCP2_HUMAN GRO2_RABIT GROA_BOVIN GROB_BOVIN
GROG_BOVIN GRO_CAVPO GRO_CRIGR GRO_HUMAN
GRO_MOUSE GRO_RAT IL8_BOVIN IL8_CANFA
IL8_CAVPO IL8_CERTO IL8_HUMAN IL8_MACMU
IL8_PIG IL8_RABIT IL8_SHEEP INIG_HUMAN
INIG_MOUSE INIG_RAT LIX_MOUSE LIX_RAT
MI2A_HUMAN MI2A_RAT MI2B_HUMAN MI2B_RAT
MIG_HUMAN MIG_MOUSE MIP2_MOUSE MIP2_RAT
O43927 O46678 O73912 O93442
PF4L_HUMAN PF4L_PIG PLF4_BOVIN PLF4_HUMAN
PLF4_PIG PLF4_RAT PLF4_SHEEP PLFV_HUMAN
True Positive Partials
Codes involving 2 elements
O14625
Sequence Titles
AMC2_PIG    ALVEOLAR MACROPHAGE CHEMOTACTIC FACTOR II PRECURSOR (AMCF-II) - SUS SCROFA (PIG). 
EMF1_CHICK EMBRYO FIBROBLAST PROTEIN 1 PRECURSOR (EMF-1) (9E3) (CEF-4) - GALLUS GALLUS (CHICKEN).
EN78_HUMAN NEUTROPHIL ACTIVATING PROTEIN ENA-78 PRECURSOR - HOMO SAPIENS (HUMAN).
GCP2_BOVIN GRANULOCYTE CHEMOTACTIC PROTEIN 2 (GCP-2) - BOS TAURUS (BOVINE).
GCP2_HUMAN GRANULOCYTE CHEMOTACTIC PROTEIN 2 PRECURSOR (GCP-2) - HOMO SAPIENS (HUMAN).
GRO2_RABIT GROWTH REGULATED PROTEIN HOMOLOG PRECURSOR (GRO HOMOLOG) - ORYCTOLAGUS CUNICULUS (RABBIT).
GROA_BOVIN GROWTH REGULATED PROTEIN HOMOLOG ALPHA PRECURSOR (GRO-ALPHA) - BOS TAURUS (BOVINE).
GROB_BOVIN GROWTH REGULATED PROTEIN HOMOLOG BETA PRECURSOR (GRO-BETA) - BOS TAURUS (BOVINE).
GROG_BOVIN GROWTH REGULATED PROTEIN HOMOLOG GAMMA PRECURSOR (GRO-GAMMA) - BOS TAURUS (BOVINE).
GRO_CAVPO GROWTH REGULATED PROTEIN PRECURSOR - CAVIA PORCELLUS (GUINEA PIG).
GRO_CRIGR GROWTH REGULATED PROTEIN PRECURSOR - CRICETULUS GRISEUS (CHINESE HAMSTER).
GRO_HUMAN GROWTH REGULATED PROTEIN PRECURSOR (MELANOMA GROWTH STIMULATORY ACTIVITY) (MGSA) (NEUTROPHIL-ACTIVATING PROTEIN 3) (NAP-3) - HOMO SAPIENS (HUMAN).
GRO_MOUSE GROWTH REGULATED PROTEIN PRECURSOR (PLATELET-DERIVED GROWTH FACTOR- INDUCIBLE PROTEIN KC) (SECRETORY PROTEIN N51) - MUS MUSCULUS (MOUSE).
GRO_RAT GROWTH REGULATED PROTEIN PRECURSOR (CYTOKINE-INDUCED NEUTROPHIL CHEMOATTRACTANT) (CINC-1) (PLATELET-DERIVED GROWTH FACTOR-INDUCIBLE PROTEIN KC) - RATTUS NORVEGICUS (RAT).
IL8_BOVIN INTERLEUKIN-8 PRECURSOR (IL-8) - BOS TAURUS (BOVINE).
IL8_CANFA INTERLEUKIN-8 PRECURSOR (IL-8) - CANIS FAMILIARIS (DOG).
IL8_CAVPO INTERLEUKIN-8 PRECURSOR (IL-8) (NEUTROPHIL ATTRACTANT PROTEIN 1) (NAP-1) - CAVIA PORCELLUS (GUINEA PIG).
IL8_CERTO INTERLEUKIN-8 PRECURSOR (IL-8) - CERCOCEBUS TORQUATUS ATYS (RED-CROWNED MANGABEY) (SOOTY MANGABEY).
IL8_HUMAN INTERLEUKIN-8 PRECURSOR (IL-8) (MONOCYTE-DERIVED NEUTROPHIL CHEMOTACTIC FACTOR) (MDNCF) (T-CELL CHEMOTACTIC FACTOR) (NEUTROPHIL- ACTIVATING PROTEIN 1) (NAP-1) (LYMPHOCYTE-DERIVED NEUTROPHIL- ACTIVATING FACTOR) (LYNAP) (PROTEIN 3-10C) (NEUTROPHIL-ACTIVATING FACTOR) (NAF) (GRANULOCYTE CHEMOTACTIC PROTEIN 1) (GCP-1) (EMOCTAKIN) - HOMO SAPIENS (HUMAN).
IL8_MACMU INTERLEUKIN-8 PRECURSOR (IL-8) - MACACA MULATTA (RHESUS MACAQUE), AND MACACA NEMESTRINA (PIG-TAILED MACAQUE).
IL8_PIG INTERLEUKIN-8 PRECURSOR (IL-8) (ALVEOLAR MACROPHAGE CHEMOTACTIC FACTOR I) (AMCF-I) - SUS SCROFA (PIG).
IL8_RABIT INTERLEUKIN-8 PRECURSOR (IL-8) (NEUTROPHIL ATTRACTANT/ACTIVATION PROTEIN-1) (NAP-1) (PERMEABILITY FACTOR 1) (RPF1) - ORYCTOLAGUS CUNICULUS (RABBIT).
IL8_SHEEP INTERLEUKIN-8 PRECURSOR (IL-8) - OVIS ARIES (SHEEP).
INIG_HUMAN INTERFERON-GAMMA INDUCED PROTEIN PRECURSOR (GAMMA-IP10) - HOMO SAPIENS (HUMAN).
INIG_MOUSE INTERFERON-GAMMA INDUCED PROTEIN CRG-2 PRECURSOR (GAMMA-IP10) (IP-10) (C7) - MUS MUSCULUS (MOUSE).
INIG_RAT MOB-1 PROTEIN PRECURSOR (INTERFERON INDUCIBLE PROTEIN 10) (IP-10) - RATTUS NORVEGICUS (RAT).
LIX_MOUSE CYTOKINE LIX PRECURSOR - MUS MUSCULUS (MOUSE).
LIX_RAT CYTOKINE LIX PRECURSOR - RATTUS NORVEGICUS (RAT).
MI2A_HUMAN MACROPHAGE INFLAMMATORY PROTEIN-2-ALPHA PRECURSOR (MIP2-ALPHA) (GROWTH REGULATED PROTEIN BETA) (GRO-BETA) - HOMO SAPIENS (HUMAN).
MI2A_RAT MACROPHAGE INFLAMMATORY PROTEIN-2-ALPHA (MIP2-ALPHA) (CINC-2-ALPHA) - RATTUS NORVEGICUS (RAT).
MI2B_HUMAN MACROPHAGE INFLAMMATORY PROTEIN-2-BETA PRECURSOR (MIP2-BETA) (GROWTH REGULATED PROTEIN GAMMA) (GRO-GAMMA) - HOMO SAPIENS (HUMAN).
MI2B_RAT MACROPHAGE INFLAMMATORY PROTEIN-2-BETA PRECURSOR (MIP2-BETA) (CINC- 2-BETA) - RATTUS NORVEGICUS (RAT).
MIG_HUMAN GAMMA INTERFERON INDUCED MONOKINE PRECURSOR (MIG) - HOMO SAPIENS (HUMAN).
MIG_MOUSE GAMMA INTERFERON INDUCED MONOKINE PRECURSOR (MIG) (M119) - MUS MUSCULUS (MOUSE).
MIP2_MOUSE MACROPHAGE INFLAMMATORY PROTEIN 2 PRECURSOR (MIP2) - MUS MUSCULUS (MOUSE).
MIP2_RAT MACROPHAGE INFLAMMATORY PROTEIN 2 PRECURSOR (MIP2) (CINC-3) - RATTUS NORVEGICUS (RAT).
O43927 CXC CHEMOKINE PRECURSOR - HOMO SAPIENS (HUMAN).
O46678 GRO - OVIS ARIES (SHEEP).
O73912 K60 PROTEIN PRECURSOR - GALLUS GALLUS (CHICKEN).
O93442 LFCA-1 PROTEIN PRECURSOR - LAMPETRA FLUVIATILIS (RIVER LAMPREY).
PF4L_HUMAN PLATELET BASIC PROTEIN PRECURSOR (PBP) [CONTAINS: CONNECTIVE-TISSUE ACTIVATING PEPTIDE III (CTAP-III); LOW-AFFINITY PLATELET FACTOR IV (LA-PF4); BETA-THROMBOGLOBULIN (BETA-TG); NEUTROPHIL-ACTIVATING PEPTIDE 2 (NAP-2)] - HOMO SAPIENS (HUMAN).
PF4L_PIG PLATELET BASIC PROTEIN PRECURSOR (PBP) - SUS SCROFA (PIG).
PLF4_BOVIN PLATELET FACTOR 4 (PF-4) - BOS TAURUS (BOVINE).
PLF4_HUMAN PLATELET FACTOR 4 PRECURSOR (PF-4) (ONCOSTATIN A) (IROPLACT) - HOMO SAPIENS (HUMAN).
PLF4_PIG PLATELET FACTOR 4 (PF-4) - SUS SCROFA (PIG).
PLF4_RAT PLATELET FACTOR 4 PRECURSOR (PF-4) - RATTUS NORVEGICUS (RAT).
PLF4_SHEEP PLATELET FACTOR 4 (PF-4) - OVIS ARIES (SHEEP).
PLFV_HUMAN PLATELET FACTOR 4 VARIANT PRECURSOR (PF4VAR1) - HOMO SAPIENS (HUMAN).

O14625 PUTATIVE ALPHA CHEMOKINE - HOMO SAPIENS (HUMAN).
Scan History
OWL26_3    2  100  NSINGLE    
SPTR37_9f 2 90 NSINGLE
Initial Motifs
Motif 1  width=9
Element Seqn Id St Int Rpt
RCQCIKTHS IL8_CANFA 33 33 -
RCQCIKTHS IL8_RABIT 33 33 -
SCVCVKTSS PLF4_RAT 43 43 -
RCTCLRVTL GCP2_HUMAN 11 11 -
QCVCLKTTS PLF4_BOVIN 24 24 -
QCVCLKTTS NRL_1PLFA 2 2 -
RCTCIDFHE RRU17035 29 29 -
RCQCINTHS AMC1_PIG 33 33 -
RCQCISTHS EMFI_CHICK 32 32 -
RCNCIHIDD INIG_MOUSE 29 29 -
RCTCISISN INIG_HUMAN 29 29 -
RCSCISTSR MIG_MOUSE 29 29 -
RCQCLQTMT GRO_CRIGR 36 36 -
RCQCLTTLP MIP2_RAT 35 35 -
RCQCLQTLQ MI2B_HUMAN 42 42 -
RCMCIKTTS PF4L_HUMAN 62 62 -

Motif 2 width=22
Element Seqn Id St Int Rpt
ITSLEVIKAGPHCAVPQLIATL PLF4_RAT 59 7 -
IQDVKLTPSGPHCKNVEIIATL EMFI_CHICK 48 7 -
IKELRVIESGPHCENSEIIVKL AMC1_PIG 49 7 -
ISSLEVIGAGLHCPSPQLIATL NRL_1PLFA 17 6 -
IGKLEIIPASLSCPHVEIIATM RRU17035 45 7 -
IQSLKVTPPGPHCTQTEVIATL GRO_CRIGR 51 6 -
IQSLTVTPPGPHCAQTEVIATL MIP2_RAT 50 6 -
IQSVNVRSPGPHCAQTEVIATL MI2B_HUMAN 57 6 -
IQSLEVIGKGTHCNQVEVIATL PF4L_HUMAN 77 6 -
IKELRVIDSGPHCENSEIIVKL IL8_CANFA 49 7 -
IKELRVIESGPHCANSEIIVKL IL8_RABIT 49 7 -
IGKLQVFPAGPQCSKVEVVASL GCP2_HUMAN 26 6 -
ISSLEVIGAGTHCPSPQLLATK PLF4_BOVIN 39 6 -
LKDLKQFAPSPNCNKTEIIATL MIG_MOUSE 45 7 -
LEKLEIIPASQFCPRVEIIATM INIG_HUMAN 45 7 -
IGKLEIIPASLSCPRVEIIATM INIG_MOUSE 45 7 -

Motif 3 width=19
Element Seqn Id St Int Rpt
KTGRKICLDQQRPLYKKIL PLF4_BOVIN 61 0 -
KNGDQTCLDPDSANVKKLM MIG_MOUSE 67 0 -
KKGEKRCLNPESKAIKNLL INIG_HUMAN 68 1 -
KNDEQRCLNPESKTIKNLM INIG_MOUSE 68 1 -
KNGQEACLNPEAPMVQKIV GRO_CRIGR 73 0 -
KNNEKRCLNPESEAIKSLL RRU17035 68 1 -
KTGRKICLDQQNPLYKKII NRL_1PLFA 39 0 -
VNGKEVCLDPKEKWVQKVV AMC1_PIG 71 0 -
KDGHEVCLNPEAPLVQRIV MIP2_RAT 72 0 -
KNGKKACLNPASPMVQKII MI2B_HUMAN 79 0 -
KDGRKICLDPDAPRIKKIV PF4L_HUMAN 99 0 -
FNGNEVCLDPKEKWVQKVV IL8_CANFA 71 0 -
VDGRELCLDPKEKWVQKVV IL8_RABIT 71 0 -
KNGSKICLDRQVPLYKKII PLF4_RAT 81 0 -
KDGREVCLDPTAPWVQLIV EMFI_CHICK 70 0 -
KNGKQVCLDPEAPFLKKVI GCP2_HUMAN 48 0 -
Final Motifs
Motif 1  width=9
Element Seqn Id St Int Rpt
RCQCLKTLP MIP2_MOUSE 35 35 -
RCQCLQTVA GRO_RAT 32 32 -
RCQCLQTMA GRO_MOUSE 32 32 -
RCQCLKTLP MI2A_RAT 4 4 -
RCQCLKTLP MI2B_RAT 36 36 -
RCQCLQTLQ GROG_BOVIN 38 38 -
RCQCLQTMT GRO_CRIGR 36 36 -
RCQCLQTLQ GROA_BOVIN 39 39 -
RCQCLQTLQ GROB_BOVIN 39 39 -
RCQCLTTLP MIP2_RAT 35 35 -
RCQCLQTLQ GRO2_RABIT 39 39 -
RCQCLQTLQ MI2A_HUMAN 42 42 -
RCQCLQTVQ O46678 38 38 -
RCQCLQTLQ GRO_HUMAN 42 42 -
RCQCLQTLQ MI2B_HUMAN 42 42 -
RCMCIKTTS PF4L_HUMAN 62 62 -
RCQCIETHS O73912 33 33 -
RCQCISTHS EMF1_CHICK 32 32 -
RCMCLTTTP AMC2_PIG 51 51 -
RCVCLTTTP GCP2_BOVIN 11 11 -
RCQCIKTHS IL8_SHEEP 33 33 -
RCLCLNTVS PF4L_PIG 53 53 -
RCQCIKTHS IL8_CANFA 33 33 -
RCQCIKTHS IL8_RABIT 33 33 -
RCQCIKTHS IL8_BOVIN 33 33 -
RCQCINTHS IL8_PIG 33 33 -
RCQCIKTYS IL8_HUMAN 33 33 -
RCECIKTYS IL8_MACMU 33 33 -
RCLCIKTYS IL8_CERTO 33 33 -
RCVCLQTTQ EN78_HUMAN 48 48 -
RCVCLTVTP LIX_MOUSE 52 52 -
RCVCVKTIS PLF4_PIG 24 24 -
QCLCVKTTS PLF4_HUMAN 40 40 -
RCRCLRPVR GRO_CAVPO 39 39 -
QCVCLKTTS PLF4_SHEEP 24 24 -
QCLCVKTTS PLFV_HUMAN 43 43 -
SCVCVKTSS PLF4_RAT 43 43 -
RCVCLTLAP LIX_RAT 49 49 -
RCTCLRVTL GCP2_HUMAN 11 11 -
QCVCLKTTS PLF4_BOVIN 24 24 -
RCQCIKIHT IL8_CAVPO 33 33 -
RCSCISTSR MIG_MOUSE 29 29 -
RCSCISTNQ MIG_HUMAN 30 30 -
RCQCVHVIS O93442 30 30 -
RCTCIDFHE INIG_RAT 29 29 -
RCTCISISN INIG_HUMAN 29 29 -
RCNCIHIDD INIG_MOUSE 29 29 -
RCRCVQESS O43927 32 32 -

Motif 2 width=22
Element Seqn Id St Int Rpt
IQSLSVTPPGPHCAQTEVIATL MIP2_MOUSE 50 6 -
IQSLKVMPPGPHCTQTEVIATL GRO_RAT 47 6 -
IQSLKVLPSGPHCTQTEVIATL GRO_MOUSE 47 6 -
IQSLTVTPPGPHCTQTEVIATL MI2A_RAT 19 6 -
IQSLTVTPPGPHCTQTEVIATL MI2B_RAT 51 6 -
IQSVKVTTPGPHCDQTEVIATL GROG_BOVIN 53 6 -
IQSLKVTPPGPHCTQTEVIATL GRO_CRIGR 51 6 -
IQSVKVTTPGPHCDQTEVIASL GROA_BOVIN 54 6 -
IQSVKVTTPGPHCDQTEVIASL GROB_BOVIN 54 6 -
IQSLTVTPPGPHCAQTEVIATL MIP2_RAT 50 6 -
IQSVKVTTPGPHCDQTEVIASL GRO2_RABIT 54 6 -
IQSVKVKSPGPHCAQTEVIATL MI2A_HUMAN 57 6 -
MQSVKVTPPGPHCGQTEVIATL O46678 53 6 -
IQSVNVKSPGPHCAQTEVIATL GRO_HUMAN 57 6 -
IQSVNVRSPGPHCAQTEVIATL MI2B_HUMAN 57 6 -
IQSLEVIGKGTHCNQVEVIATL PF4L_HUMAN 77 6 -
IQNVNLTPSGPHCKNVEVIATL O73912 49 7 -
IQDVKLTPSGPHCKNVEIIATL EMF1_CHICK 48 7 -
ISDLQVIPAGPQCSKAEVIATL AMC2_PIG 66 6 -
VSDLQVIAAGPQCSKVEVIATL GCP2_BOVIN 26 6 -
IKELRVIESGPHCENSEIIVKL IL8_SHEEP 49 7 -
IQSLEVIRAGAHCAKVEVIATL PF4L_PIG 68 6 -
IKELRVIDSGPHCENSEIIVKL IL8_CANFA 49 7 -
IKELRVIESGPHCANSEIIVKL IL8_RABIT 49 7 -
IKELRVIESGPHCENSEIIVKL IL8_BOVIN 49 7 -
IKELRVIESGPHCENSEIIVKL IL8_PIG 49 7 -
IKELRVIESGPHCANTEIIVKL IL8_HUMAN 49 7 -
IKELRVIESGPHCANTEIIVKL IL8_MACMU 49 7 -
IKELRVIESGPHCVNTEIIVKL IL8_CERTO 49 7 -
ISNLQVFAIGPQCSKVEVVASL EN78_HUMAN 63 6 -
IANLEVIPAGPQCPTVEVIAKL LIX_MOUSE 67 6 -
ISSLEVIGAGPHCPSPQLIATL PLF4_PIG 39 6 -
ITSLEVIKAGPHCPTAQLIATL PLF4_HUMAN 55 6 -
IQSVAVTAPGPHCHQTEVLATL GRO_CAVPO 54 6 -
ISSLEVIGAGLHCPSPQLIATL PLF4_SHEEP 39 6 -
ITSLEVIKAGPHCPTAQLIATL PLFV_HUMAN 58 6 -
ITSLEVIKAGPHCAVPQLIATL PLF4_RAT 59 7 -
IANLEVIPAGPHCPKVEVIAKL LIX_RAT 64 6 -
IGKLQVFPAGPQCSKVEVVASL GCP2_HUMAN 26 6 -
ISSLEVIGAGTHCPSPQLLATK PLF4_BOVIN 39 6 -
IKELKVIESGPRCANSEIIVKL IL8_CAVPO 49 7 -
LKDLKQFAPSPNCNKTEIIATL MIG_MOUSE 45 7 -
LKDLKQFAPSPSCEKIEIIATL MIG_HUMAN 46 7 -
FQTMEVIPQSSNCKNVEIIVTM O93442 46 7 -
IGKLEIIPASLSCPHVEIIATM INIG_RAT 45 7 -
LEKLEIIPASQFCPRVEIIATM INIG_HUMAN 45 7 -
IGKLEIIPASLSCPRVEIIATM INIG_MOUSE 45 7 -
IDRIQILPRGNGCPRKEIIVWK O43927 48 7 -

Motif 3 width=19
Element Seqn Id St Int Rpt
KGGQKVCLDPEAPLVQKII MIP2_MOUSE 72 0 -
KNGREACLDPEAPMVQKIV GRO_RAT 69 0 -
KNGREACLDPEAPLVQKIV GRO_MOUSE 69 0 -
KDGQEVCLNPQAPRLQKII MI2A_RAT 41 0 -
KDGQEVCLNPQAPRLQKII MI2B_RAT 73 0 -
KTGQEVCLNPAAPMVKKII GROG_BOVIN 75 0 -
KNGQEACLNPEAPMVQKIV GRO_CRIGR 73 0 -
KTGQEVCLNPTAPMVKKII GROA_BOVIN 76 0 -
KTGQEVCLNPTAPMVKKII GROB_BOVIN 76 0 -
KDGHEVCLNPEAPLVQRIV MIP2_RAT 72 0 -
KTGQEVCLNPTAPVVKKII GRO2_RABIT 76 0 -
KNGQKACLNPASPMVKKII MI2A_HUMAN 79 0 -
KTGQEVCLNPAAPMVKKII O46678 75 0 -
KNGRKACLNPASPIVKKII GRO_HUMAN 79 0 -
KNGKKACLNPASPMVQKII MI2B_HUMAN 79 0 -
KDGRKICLDPDAPRIKKIV PF4L_HUMAN 99 0 -
KDGREVCLDPTAPWVKLII O73912 71 0 -
KDGREVCLDPTAPWVQLIV EMF1_CHICK 70 0 -
KNGKEVCLDPKAPLIKKIV AMC2_PIG 88 0 -
KNGREVCLDPEAPLIKKIV GCP2_BOVIN 48 0 -
TNGKEVCLDPKEKWVQKVV IL8_SHEEP 71 0 -
KNDKKICLDPEAPRIKKIV PF4L_PIG 90 0 -
FNGNEVCLDPKEKWVQKVV IL8_CANFA 71 0 -
VDGRELCLDPKEKWVQKVV IL8_RABIT 71 0 -
TNGNEVCLNPKEKWVQKVV IL8_BOVIN 71 0 -
VNGKEVCLDPKEKWVQKVV IL8_PIG 71 0 -
SDGRELCLDPKENWVQRVV IL8_HUMAN 71 0 -
SDGRELCLDPKEPWVQRVV IL8_MACMU 71 0 -
SDGRELCLDPKEPWVQRVV IL8_CERTO 71 0 -
KNGKEICLDPEAPFLKKVI EN78_HUMAN 85 0 -
KNQKEVCLDPEAPVIKKII LIX_MOUSE 89 0 -
KKGHKICLDPQNLLYKKII PLF4_PIG 61 0 -
KNGRKICLDLQAPLYKKII PLF4_HUMAN 77 0 -
KDGREACLDPEAPMVQKVL GRO_CAVPO 76 0 -
KTGRKICLDQQNPLYKKII PLF4_SHEEP 61 0 -
KNGRKICLDLQALLYKKII PLFV_HUMAN 80 0 -
KNGSKICLDRQVPLYKKII PLF4_RAT 81 0 -
NQKDNVCLDPQAPLIKKVI LIX_RAT 87 1 -
KNGKQVCLDPEAPFLKKVI GCP2_HUMAN 48 0 -
KTGRKICLDQQRPLYKKIL PLF4_BOVIN 61 0 -
SDNRQLCLDPKKKWVQDVV IL8_CAVPO 71 0 -
KNGDQTCLDPDSANVKKLM MIG_MOUSE 67 0 -
KNGVQTCLNPDSADVKELI MIG_HUMAN 68 0 -
STNNQICLNPDAPWVRKVI O93442 69 1 -
KNNEKRCLNPESEAIKSLL INIG_RAT 68 1 -
KKGEKRCLNPESKAIKNLL INIG_HUMAN 68 1 -
KNDEQRCLNPESKTIKNLM INIG_MOUSE 68 1 -
KNKSIVCVDPQAEWIQRMM O43927 70 0 -