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PR00348

Identifier
UBIQUITIN  [View Relations]  [View Alignment]  
Accession
PR00348
No. of Motifs
3
Creation Date
08-JAN-1994  (UPDATE 25-JUN-1999)
Title
Ubiquitin signature
Database References

PROSITE; PS00299 UBIQUITIN
PFAM; PF00240 ubiquitin
INTERPRO; IPR000626
PDB; 1UBQ
SCOP; 1UBQ
CATH; 1UBQ
Literature References
1. WIBORG, O., PEDERSEN. M.S., WIND, A., BERGLUND, L.E., MARCKER, K.A. AND
VUUST, J.
The human ubiquitin multigene family - Some sequences contain multiple 
directly repeated ubiquitin coding sequences.
EMBO J. 4(3) 755-759 (1985).
 
2. SWINDLE, J., AJIOKA, J., EISEN, H., SANWAL, B., JACQUEMOT, C., BROWDER, 
Z. AND BUCK, G.
The genomic organization and transcription of the ubiquitin genes of
Trypanosoma cruzi.
EMBO J. 7(4) 1121-1127 (1988).
 
3. GRAHAM, R.W., JONES, D. AND CANDIDO, E.P.M.
UbiA, the major polyubiquitin locus in Caenorhabditis elegans, has unusual
structural features and is constitutively expressed.
MOL.CELL.BIOL. 9(1) 268-277 (1989).
 
4. VIJAY-KUMAR, S., BUGG, C.E., WILKINSON, K.D., VIERSTRA, R.D., HATFIELD,
P.M. AND COOK, W.J.
Comparison of the 3-dimensional structures of human, yeast, and oat
ubiquitin.
J.BIOL.CHEM. 262(13) 6396-6399 (1987).

Documentation
Ubiquitin, a small 76-residue protein present in all eukaryotic cells [1],
is highly conserved in nature, species as diverse as humans and insects
having identical sequences [1]. Ubiquitin is required for ATP-dependent
non-lysosomal intracellular protein degradation [1], sensitizing proteins
to attack by intracellular proteases [2]. The reaction involves covalent
bonding of ubiquitin to the protein to be degraded or `labelled', the bond
forming between the C-terminal Gly of ubiquitin (which extends from the
globular body of the peptide) and Lys side-chains of the target protein
[1]. Proteins degraded in such a manner include most defective intra-
cellular proteins and normal proteins with a rapid turnover rate. 
 
The most abundant form of ubiquitin is the histone 2A (H2A)-ubiquitin
conjugate found in the nucleus. The conjugate is usually found in actively
transcribed chromosomal regions, suggesting a possible role in either DNA
repair or gene expression [1,3]. All organisms possess a poly-ubiquitin
gene, with various numbers of tandem repeats (ranging from 3 in
Dictyostelium discoideum to 15 in Drosophila melanogaster): the polyprotein
is proteolytically cleaved to produce free ubiquitin [3]. Although mostly
present in the cytoplasm, the protein has also been found on the cell
surface, associated with various receptors, such as lymphocyte homing
receptor and platelet derived growth factor receptor [4]. 
 
UBIQUITIN is a 3-element fingerprint that provides a signature for ubiquitin
and ubiquitin-like proteins. The fingerprint was derived from an initial 
alignment of 10 sequences: the motifs span virtually the full alignment
length, motif 3 including most of the region encoded by PROSITE pattern
UBIQUITIN (PS00299), which contains the conserved C-terminal heptapeptide.
Two iterations on OWL22.1 were required to reach convergence, at which
point a true set comprising 105 sequences was identified. Five partial
matches were also found, all of which are ubiquitin-like proteins.
 
An update on SPTR37_9f identified a true set of 101 sequences, and 16
partial matches.
Summary Information
 101 codes involving  3 elements
16 codes involving 2 elements
Composite Feature Index
3101101101
28168
123
True Positives
NED8_HUMAN    NED8_MOUSE    O00945        O04829        
O13256 O13697 O14257 O14399
O15205 O24122 O35079 O35080
O42388 O44819 O46314 O46543
O49905 O49906 O49907 O59962
O59963 O59964 O60010 O60036
O65332 O65381 O74216 O74274
O74295 O74819 O80715 P90616
P93135 P93379 P93501 Q00811
Q01867 Q17000 Q17001 Q17033
Q24903 Q25400 Q25422 Q25426
Q27191 Q27192 Q27194 Q27195
Q27196 Q27935 Q38875 Q39256
Q39257 Q39926 Q40164 Q40596
Q40641 Q41067 Q41411 Q41570
Q41646 Q41751 Q41752 Q41753
Q41754 Q42397 Q42415 Q60507
Q62317 Q63429 Q63446 Q65815
Q90195 Q91889 Q91890 Q92332
Q93116 Q93725 Q95260 UBIL_NPVAC
UBIL_NPVOP UBIQ_ACACA UBIQ_ACECL UBIQ_AGLNE
UBIQ_CAEEL UBIQ_CHLRE UBIQ_COPCO UBIQ_DICDI
UBIQ_EIMBO UBIQ_EUPEU UBIQ_HUMAN UBIQ_LEIMA
UBIQ_LEITA UBIQ_NEUCR UBIQ_PHYIN UBIQ_SOYBN
UBIQ_STRPU UBIQ_TETPY UBIQ_TRYBB UBIQ_TRYCR
UBIQ_YEAST
True Positive Partials
Codes involving 2 elements
DSK2_YEAST O11993 O44820 O64736
P91057 Q03919 UBIL_CAEBR UBIL_CAEEL
UBIL_HUMAN UBIL_MOUSE UBIM_CRIGR UBIM_PIG
UBIM_RAT UCRP_HUMAN UCRP_MOUSE YAUG_SCHPO
Sequence Titles
NED8_HUMAN  UBIQUITIN-LIKE PROTEIN NEDD8 - HOMO SAPIENS (HUMAN). 
NED8_MOUSE UBIQUITIN-LIKE PROTEIN NEDD8 - MUS MUSCULUS (MOUSE).
O00945 UBIQUITIN - TETRAHYMENA VORAX.
O04829 UBIQUITIN EXTENSION PROTEIN - SOLANUM TUBEROSUM (POTATO).
O13256 (2'-5')OLIGOADENYLATE SYNTHETASE (EC 2.7.7.-) ((2-5')OLIGO(A) SYNTHETASE) (2-5A SYNTHETASE) (2',5'-OLIGO ADENYLATE SYNTHETASE B) - GALLUS GALLUS (CHICKEN).
O13697 UBIQUITIN - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O14257 UBIQUITIN-LIKE PROTEIN C6G10.11C - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O14399 UBIQUITIN-LIKE PROTEIN - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O15205 DIUBIQUITIN - HOMO SAPIENS (HUMAN).
O24122 UBIQUITIN - NICOTIANA PLUMBAGINIFOLIA (LEADWORT-LEAVED TOBACCO).
O35079 POLYUBIQUITIN - CRICETULUS GRISEUS (CHINESE HAMSTER).
O35080 POLYUBIQUITIN - CRICETULUS GRISEUS (CHINESE HAMSTER).
O42388 UBIQUITIN-RIBOSOMAL PROTEIN FUSION PROTEIN - GALLUS GALLUS (CHICKEN).
O44819 F52C6.4 PROTEIN - CAENORHABDITIS ELEGANS.
O46314 POLYUBIQUITIN - AMOEBA PROTEUS (AMOEBA).
O46543 POLYUBIQUITIN - OVIS ARIES (SHEEP).
O49905 POLYUBIQUITIN - NICOTIANA TABACUM (COMMON TOBACCO).
O49906 UBIQUITIN EXTENSION PROTEIN - NICOTIANA TABACUM (COMMON TOBACCO).
O49907 POLYUBIQUITIN - NICOTIANA TABACUM (COMMON TOBACCO).
O59962 UBIQUITIN FUSION PROTEIN - MAGNAPORTHE GRISEA (RICE BLAST FUNGUS).
O59963 UBIQUITIN FUSION PROTEIN - MAGNAPORTHE GRISEA (RICE BLAST FUNGUS).
O59964 POLY-UBIQUITIN - MAGNAPORTHE GRISEA (RICE BLAST FUNGUS).
O60010 POLYUBIQUITIN - BOTRYTIS CINEREA (BOTRYOTINIA FUCKELIANA).
O60036 UBIQUITIN FUSION PROTEIN - CANDIDA ALBICANS (YEAST).
O65332 POLYUBIQUITIN - ELAEAGNUS UMBELLATA.
O65381 F12F1.15 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O74216 MONOUBIQUITIN/CARBOXY EXTENSION PROTEIN FUSION - BOTRYTIS CINEREA (BOTRYOTINIA FUCKELIANA).
O74274 POLYUBIQUITIN - CANDIDA ALBICANS (YEAST).
O74295 POLYUBIQUITIN - GIBBERELLA PULICARIS.
O74819 UBI4 - UBIQUITIN FAMILY PROTEIN - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O80715 UBIQUITIN EXTENSION PROTEIN (UBQ6) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P90616 POLYUBIQUITIN - TETRAHYMENA THERMOPHILA.
P93135 POLYUBIQUITIN - FRAGARIA ANANASSA (STRAWBERRY).
P93379 UBIQUITIN - NICOTIANA TABACUM (COMMON TOBACCO).
P93501 UBIQUITIN-LIKE PROTEIN - PHASEOLUS VULGARIS (KIDNEY BEAN) (FRENCH BEAN).
Q00811 POLYUBIQUITIN - CRYPTOCOCCUS NEOFORMANS (FILOBASIDIELLA NEOFORMANS).
Q01867 UBIQUITIN - PHANEROCHAETE CHRYSOSPORIUM.
Q17000 POLYUBIQUITIN - ARTEMIA SANFRANCISCANA (BRINE SHRIMP) (ARTEMIA FRANCISCANA).
Q17001 UBIQUITIN UNIT IV - ARTEMIA SANFRANCISCANA (BRINE SHRIMP) (ARTEMIA FRANCISCANA).
Q17033 POLYUBIQUITIN - ANOPHELES GAMBIAE (AFRICAN MALARIA MOSQUITO).
Q24903 UBIQUITIN - ECHINOCOCCUS MULTILOCULARIS.
Q25400 UBIQUITIN C-TERMINAL EXTENSION PROTEIN UBICEP86 - LITOMOSOIDES SIGMODONTIS.
Q25422 UBIQUITIN-FUSION PROTEIN - LEISHMANIA TARENTOLAE (SAUROLEISHMANIA TARENTOLAE).
Q25426 UBIQUITIN - LEISHMANIA TARENTOLAE (SAUROLEISHMANIA TARENTOLAE).
Q27191 UBIQUITIN - TETRAHYMENA PYRIFORMIS.
Q27192 UBIQUITIN - TETRAHYMENA PYRIFORMIS.
Q27194 UBIQUITIN - TETRAHYMENA PYRIFORMIS.
Q27195 UBIQUITIN - TETRAHYMENA PYRIFORMIS.
Q27196 UBIQUITIN - TETRAHYMENA PYRIFORMIS.
Q27935 UBIQUITIN - ENTAMOEBA HISTOLYTICA.
Q38875 POLYUBIQUITIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
Q39256 POLYUBIQUITIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
Q39257 POLYUBIQUITIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS), AND PISUM SATIVUM (GARDEN PEA).
Q39926 POLYUBIQUITIN - GRACILARIA VERRUCOSA.
Q40164 UBIQUITIN - LYCOPERSICON ESCULENTUM (TOMATO).
Q40596 PENTAMERIC POLYUBIQUITIN - NICOTIANA TABACUM (COMMON TOBACCO).
Q40641 POLYUBIQUITIN - ORYZA SATIVA (RICE).
Q41067 POLYUBIQUITIN - PINUS SYLVESTRIS (SCOTS PINE).
Q41411 POLYUBIQUITIN - SACCHARUM HYBRID (SUGARCANE).
Q41570 UBIQUITIN - TRITICUM AESTIVUM (WHEAT).
Q41646 POLYUBIQUITIN - VOLVOX CARTERI.
Q41751 POLYUBIQUITIN - ZEA MAYS (MAIZE).
Q41752 UBIQUITIN - ZEA MAYS (MAIZE).
Q41753 UBIQUITIN FUSION PROTEIN - ZEA MAYS (MAIZE).
Q41754 UBIQUITIN - ZEA MAYS (MAIZE).
Q42397 HEXAUBIQUITIN PROTEIN - HELIANTHUS ANNUUS (COMMON SUNFLOWER).
Q42415 POLYUBIQUITIN - ZEA MAYS (MAIZE).
Q60507 POLYUBIQUITIN - CRICETULUS GRISEUS (CHINESE HAMSTER).
Q62317 UBIQUITIN C (TI-225) (UBIQUITIN C) (POLYUBIQUITIN) - MUS MUSCULUS (MOUSE).
Q63429 POLYUBIQUITIN - RATTUS NORVEGICUS (RAT).
Q63446 POLYUBIQUITIN - RATTUS NORVEGICUS (RAT).
Q65815 POLYPROTEIN - MUCOSAL DISEASE VIRUS.
Q90195 VIRAL UBIQUITIN PROTEIN - SPODOPTERA EXIGUA NUCLEOPOLYHEDROVIRUS.
Q91889 UBIQUITIN-LIKE FUSION PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q91890 UBIQUITIN-LIKE FUSION PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q92332 POLYUBIQUITIN - SCHIZOPHYLLUM COMMUNE (BRACKET FUNGUS).
Q93116 UB52 - ACROPORA MILLEPORA.
Q93725 F45H11.2 PROTEIN - CAENORHABDITIS ELEGANS.
Q95260 UBIQUITIN/RIBOSOMAL FUSION PROTEIN - SUS SCROFA (PIG).
UBIL_NPVAC UBIQUITIN-LIKE PROTEIN - AUTOGRAPHA CALIFORNICA NUCLEAR POLYHEDROSIS VIRUS (ACMNPV).
UBIL_NPVOP UBIQUITIN-LIKE PROTEIN - ORGYIA PSEUDOTSUGATA MULTICAPSID POLYHEDROSIS VIRUS (OPMNPV).
UBIQ_ACACA UBIQUITIN - ACANTHAMOEBA CASTELLANII (AMOEBA).
UBIQ_ACECL UBIQUITIN - ACETABULARIA CLIFTONII.
UBIQ_AGLNE UBIQUITIN - AGLAOTHAMNION NEGLECTUM.
UBIQ_CAEEL UBIQUITIN - CAENORHABDITIS ELEGANS, AND GEODIA CYDONIUM (SPONGE).
UBIQ_CHLRE UBIQUITIN - CHLAMYDOMONAS REINHARDTII.
UBIQ_COPCO UBIQUITIN - COPRINUS CONGREGATUS (INKY CAP FUNGUS).
UBIQ_DICDI UBIQUITIN - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).
UBIQ_EIMBO UBIQUITIN - EIMERIA BOVIS.
UBIQ_EUPEU UBIQUITIN - EUPLOTES EURYSTOMUS.
UBIQ_HUMAN UBIQUITIN - HOMO SAPIENS (HUMAN), BOS TAURUS (BOVINE), SUS SCROFA (PIG), CAVIA PORCELLUS (GUINEA PIG), CRICETULUS GRISEUS (CHINESE HAMSTER), CRICETULUS LONGICAUDATUS (LONG-TAILED HAMSTER) (CHINESE HAMSTER), RATTUS NORVEGICUS (RAT), MUS MUSCULUS (MOUSE), ORYCTOLAGUS CUNICULUS (RABBIT), GALLUS GALLUS (CHICKEN), XENOPUS LAEVIS (AFRICAN CLAWED FROG), DROSOPHILA MELANOGASTER (FRUIT FLY), CERATITIS CAPITATA (MEDITERRANEAN FRUIT FLY), SPODOPTERA FRUGIPERDA (FALL ARMYWORM), AND MANDUCA SEXTA (TOBACCO HAWKMOTH) (TOBACCO HORNWORM).
UBIQ_LEIMA UBIQUITIN - LEISHMANIA MAJOR.
UBIQ_LEITA UBIQUITIN - LEISHMANIA TARENTOLAE (SAUROLEISHMANIA TARENTOLAE).
UBIQ_NEUCR UBIQUITIN - NEUROSPORA CRASSA.
UBIQ_PHYIN UBIQUITIN - PHYTOPHTHORA INFESTANS (POTATO LATE BLIGHT FUNGUS).
UBIQ_SOYBN UBIQUITIN - GLYCINE MAX (SOYBEAN), PISUM SATIVUM (GARDEN PEA), AVENA SATIVA (OAT), AVENA FATUA, HORDEUM VULGARE (BARLEY), TRITICUM AESTIVUM (WHEAT), ZEA MAYS (MAIZE), HELIANTHUS ANNUUS (COMMON SUNFLOWER), ARABIDOPSIS THALIANA (MOUSE-EAR CRESS), LUPINUS ALBUS (WHITE LUPINE), LUPINUS POLYPHYLLUS (LARGE-LEAVED LUPINE), LYCOPERSICON ESCULENTUM (TOMATO), SOLANUM TUBEROSUM (POTATO), LINUM USITATISSIMUM (FLAX) (LINSEED), NICOTIANA SYLVESTRIS (WOOD TOBACCO), ASPARAGUS OFFICINALIS (GARDEN ASPARAGUS), ORYZA SATIVA (RICE), PETROSELINUM CRISPUM (PARSLEY) (PETROSELINUM HORTENSE), AND BRASSICA RAPA (TURNIP).
UBIQ_STRPU UBIQUITIN - STRONGYLOCENTROTUS PURPURATUS (PURPLE SEA URCHIN).
UBIQ_TETPY UBIQUITIN - TETRAHYMENA PYRIFORMIS.
UBIQ_TRYBB UBIQUITIN - TRYPANOSOMA BRUCEI BRUCEI.
UBIQ_TRYCR UBIQUITIN - TRYPANOSOMA CRUZI.
UBIQ_YEAST UBIQUITIN - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST), CANDIDA ALBICANS (YEAST), AND CRYPTOCOCCUS NEOFORMANS (FILOBASIDIELLA NEOFORMANS).

DSK2_YEAST UBIQUITIN-LIKE PROTEIN DSK2 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
O11993 CYTOPATHIC GENOMIC RNA, COMPLETE GENOME - MUCOSAL DISEASE VIRUS.
O44820 F52C6.3 PROTEIN - CAENORHABDITIS ELEGANS.
O64736 T27E13.16 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P91057 SIMILARITY TO UBIQUITIN - CAENORHABDITIS ELEGANS.
Q03919 HYPOTHETICAL 8.7 KD PROTEIN - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
UBIL_CAEBR UBIQUITIN-LIKE PROTEIN UBL - CAENORHABDITIS BRIGGSAE.
UBIL_CAEEL UBIQUITIN-LIKE PROTEIN UBL - CAENORHABDITIS ELEGANS.
UBIL_HUMAN UBIQUITIN-LIKE PROTEIN GDX - HOMO SAPIENS (HUMAN).
UBIL_MOUSE UBIQUITIN-LIKE PROTEIN GDX - MUS MUSCULUS (MOUSE).
UBIM_CRIGR UBIQUITIN-LIKE PROTEIN FUBI (ARSENITE-RESISTANCE PROTEIN) - CRICETULUS GRISEUS (CHINESE HAMSTER).
UBIM_PIG UBIQUITIN-LIKE/S30 RIBOSOMAL FUSION PROTEIN - SUS SCROFA (PIG).
UBIM_RAT UBIQUITIN-LIKE PROTEIN FUBI - RATTUS NORVEGICUS (RAT).
UCRP_HUMAN UBIQUITIN CROSS-REACTIVE PROTEIN (INTERFERON-INDUCED 17 KD PROTEIN) [CONTAINS: INTERFERON-INDUCED 15 KD PROTEIN] - HOMO SAPIENS (HUMAN).
UCRP_MOUSE UBIQUITIN CROSS-REACTIVE PROTEIN (INTERFERON-STIMULATED PROTEIN 15) - MUS MUSCULUS (MOUSE).
YAUG_SCHPO HYPOTHETICAL 36.8 KD PROTEIN C26A3.16 IN CHROMOSOME I - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
Scan History
OWL22_1    2  250  NSINGLE    
OWL26_0 1 250 NSINGLE
SPTR37_9f 3 500 NSINGLE
Initial Motifs
Motif 1  width=21
Element Seqn Id St Int Rpt
KTITLDVEPSDSIDNVKQKIQ UBIQ_PHYIN 11 11 -
KTITAETEPEETVADLKQKIA UBIL_NPVAC 11 11 -
KTITLEVEPSDTIENVKAKIQ NRL_1UBQ 11 11 -
KTITLEVESSDTIDNVKAKIQ UBIQ_COPCO 11 11 -
KTITLEVEPSDTIENVKAKIQ UBIQ_HUMAN 11 11 -
KTITLEVESSDTIDNVKAKIQ UBIQ_SOYBN 11 11 -
KTITLEVEASDTIENVKAKIQ UBIQ_CAEEL 11 11 -
KTITLEVESSDTIDNVKSKIQ UBIQ_YEAST 11 11 -
KTITLEVEPSDSIENVKAKIQ UBIQ_STRPU 11 11 -
KTITLEVEGSDNIENVKAKIQ UBIQ_DICDI 11 11 -

Motif 2 width=21
Element Seqn Id St Int Rpt
DKEGIPPDQQRLIFAGKQLED UBIQ_CAEEL 32 0 -
DKEGIPPDQQRLIFAGKQLED NRL_1UBQ 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_COPCO 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_HUMAN 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_SOYBN 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_YEAST 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_STRPU 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_DICDI 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_PHYIN 32 0 -
DKEGVPVDQQRLIFAGKQLED UBIL_NPVAC 32 0 -

Motif 3 width=22
Element Seqn Id St Int Rpt
SKTMADYNIQKESTLHMVLRLR UBIL_NPVAC 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_COPCO 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_HUMAN 53 0 -
GRTLADYNIQKESTLHLVLRLR UBIQ_SOYBN 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_CAEEL 53 0 -
GRTLSDYNIQKESTLHLVLRLR NRL_1UBQ 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_YEAST 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_STRPU 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_DICDI 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_PHYIN 53 0 -
Final Motifs
Motif 1  width=21
Element Seqn Id St Int Rpt
KTITLEVESSDTIDNVKAKIQ O60010 11 11 -
KTITLEVESSDTIDNVKAKIQ UBIQ_COPCO 11 11 -
KTITLEVESSDTIDNVKAKIQ Q92332 11 11 -
KTITLEVESSDTIDNVKAKIQ Q01867 11 11 -
KTITLEVESSDTIDNVKAKIQ Q00811 11 11 -
KTITLEVESSDTIDNVKAKIQ O74216 11 11 -
KTITLEVESSDTIENVKAKIQ Q41646 11 11 -
KTITLEVESSDTIENVKAKIQ UBIQ_CHLRE 11 11 -
KTITLEVEPSDTIENVKAKIQ O35079 11 11 -
KTITLEVEPSDTIENVKAKIQ UBIQ_HUMAN 11 11 -
KTITLEVEPSDTIENVKAKIQ Q95260 11 11 -
KTITLEVEPSDTIENVKAKIQ Q63446 11 11 -
KTITLEVEPSDTIENVKAKIQ Q63429 11 11 -
KTITLEVEPSDTIENVKAKIQ Q62317 11 11 -
KTITLEVEPSDTIENVKAKIQ Q60507 11 11 -
KTITLEVEPSDTIENVKAKIQ Q17033 11 11 -
KTITLEVEPSDTIENVKAKIQ Q17000 11 11 -
KTITLEVEPSDTIENVKAKIQ O46543 87 87 -
KTITLEVEPSDTIENVKAKIQ O35080 11 11 -
KTITLEVESSDTIDNVKAKIQ O04829 11 11 -
KTITLEVESSDTIDNVKAKIQ UBIQ_SOYBN 11 11 -
KTITLEVESSDTIDNVKAKIQ Q42415 11 11 -
KTITLEVESSDTIDNVKAKIQ Q42397 11 11 -
KTITLEVESSDTIDNVKAKIQ Q41754 11 11 -
KTITLEVESSDTIDNVKAKIQ Q41753 11 11 -
KTITLEVESSDTIDNVKAKIQ Q41752 11 11 -
KTITLEVESSDTIDNVKAKIQ Q41751 11 11 -
KTITLEVESSDTIDNVKAKIQ Q41570 11 11 -
KTITLEVESSDTIDNVKAKIQ Q41411 11 11 -
KTITLEVESSDTIDNVKAKIQ Q41067 11 11 -
KTITLEVESSDTIDNVKAKIQ Q40641 11 11 -
KTITLEVESSDTIDNVKAKIQ Q40596 11 11 -
KTITLEVESSDTIDNVKAKIQ Q40164 11 11 -
KTITLEVESSDTIDNVKAKIQ Q39257 11 11 -
KTITLEVESSDTIDNVKAKIQ Q38875 11 11 -
KTITLEVESSDTIDNVKAKIQ P93501 113 113 -
KTITLEVESSDTIDNVKAKIQ P93135 11 11 -
KTITLEVESSDTIDNVKAKIQ O80715 11 11 -
KTITLEVESSDTIDNVKAKIQ O65332 11 11 -
KTITLEVESSDTIDNVKAKIQ O49906 11 11 -
KTITLEVESSDTIDNVKAKIQ O24122 11 11 -
KTITLEVEASDTIENVKAKIQ UBIQ_CAEEL 11 11 -
KTITLEVESSDTIDNVKSKIQ O13697 11 11 -
KTITLEVESSDTIDNVKSKIQ UBIQ_YEAST 11 11 -
KTITLEVESSDTIDNVKSKIQ O74819 11 11 -
KTITLEVESSDTIDNVKSKIQ O74295 11 11 -
KTITLEVESSDTIDNVKSKIQ O74274 11 11 -
KTITLEVESSDTIDNVKSKIQ O60036 11 11 -
KTITLEVESSDTIDNVKSKIQ O59964 11 11 -
KTITLEVESSDTIDNVKSKIQ O59963 11 11 -
KTITLEVESSDTIDNVKSKIQ O59962 11 11 -
KTITLEVESSDTIDNVKSKIQ O49905 11 11 -
KTITLEVESSDTIDNVKSKIQ O14257 11 11 -
KTITLEVESSDTIDNVKQKIQ UBIQ_NEUCR 11 11 -
KTITLEVESSDTIENVKTKIQ Q39926 11 11 -
KTITLEVESSDTIENVKTKIQ UBIQ_AGLNE 11 11 -
KTITLEVESSDTIENVKQKIQ O49907 11 11 -
KTITLEVESSDTIENVKQKIQ UBIQ_ACACA 11 11 -
KTITLEVDSSDTIENVKAKIQ Q25400 11 11 -
KTITLDVEPSDTIENVKAKIQ UBIQ_EIMBO 11 11 -
KTIALEVESSDTIENVKAKIQ UBIQ_TRYCR 11 11 -
KTITLEVEPSDSIENVKAKIQ UBIQ_STRPU 11 11 -
KTITLEVEPSDTIENVKAKIQ Q17001 11 11 -
KTITLEVESSDTIDNVKAKIQ P93379 11 11 -
KTITLEVEPNDTIENVKAKIQ O42388 11 11 -
KTITLDVEASDTIENVKAKIQ UBIQ_TETPY 11 11 -
KTITLDVEASDTIENVKAKIQ P90616 11 11 -
KTITLDVEASDTIENVKAKIQ O00945 87 87 -
KTITLEVEGSDNIENVKAKIQ UBIQ_DICDI 11 11 -
KTITLEVESSDTVENVKSKIQ UBIQ_ACECL 11 11 -
KTITLEVEPSDSIENVKTKIQ Q93116 11 11 -
KTITLEVEPSDSIENVKAKIQ Q24903 11 11 -
KTIALEVEPSDTIENVKAKIQ Q25422 11 11 -
KTIALEVEPSDTIENVKAKIQ Q25426 11 11 -
KTIALEVEPSDTIENVKAKIQ UBIQ_LEIMA 11 11 -
RTITLEVEPSDTIENVKAKIQ Q65815 1601 1601 -
KTITLDVEQSDTIDNVKTKIQ UBIQ_EUPEU 11 11 -
KTIALEVEASDTIENVKAKIQ UBIQ_TRYBB 11 11 -
KTITLDVEPSDSIDNVKQKIQ UBIQ_PHYIN 11 11 -
KTITLDVDSSDNIENVKAKIQ Q27191 239 239 -
KTITLEVDSSDNIENVKAKIQ Q27196 87 87 -
KTITLEVEPGDSIDNVKQKIQ O46314 11 11 -
TTIALEVEPSDTIENVKAKIQ UBIQ_LEITA 11 11 -
KTITLEVKSSDTIDNVKAKIQ Q39256 89 89 -
KTITLDVDSSDNIENVKAKIQ Q27192 239 239 -
KTITLEVEPNDSIDAIKAKIQ Q27935 11 11 -
KTITLDVAQTDNIENIKAKIQ Q27194 87 87 -
KTVTVEVESTDTVEQVKQKIT Q90195 11 11 -
KTITVETEPGDTVGQVKQKIA UBIL_NPVOP 11 11 -
KTITAETEPEETVADLKQKIA UBIL_NPVAC 11 11 -
KTITLDVTSSNTINDIKSMIS Q27195 87 87 -
KEIELDIEPNDRVERIKEKVE Q93725 11 11 -
KEIEIDIEPTDKVERIKERVE NED8_MOUSE 11 11 -
KEIEIDIEPTDKVERIKERVE NED8_HUMAN 11 11 -
KQIDIEIELTDTIERIKERIE O65381 11 11 -
KTIPISIKNTDTVETLKFKVQ O44819 171 171 -
KEIELDIDPNDKVSRIKERVE O14399 11 11 -
TCFELRVSPYETVTSVKSKIQ Q91890 38 38 -
TCFELRVSPYETVTSVKSKIQ Q91889 38 38 -
KTTVYTVRPTDTVKQLKQQIY O13256 400 400 -
KRHLLQVRRSSSVAQVKAMIE O15205 100 100 -

Motif 2 width=21
Element Seqn Id St Int Rpt
DKEGIPPDQQRLIFAGKQLED O60010 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_COPCO 32 0 -
DKEGIPPDQQRLIFAGKQLED Q92332 32 0 -
DKEGIPPDQQRLIFAGKQLED Q01867 32 0 -
DKEGIPPDQQRLIFAGKQLED Q00811 32 0 -
DKEGIPPDQQRLIFAGKQLED O74216 32 0 -
DKEGIPPDQQRLIFAGKQLED Q41646 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_CHLRE 32 0 -
DKEGIPPDQQRLIFAGKQLED O35079 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_HUMAN 32 0 -
DKEGIPPDQQRLIFAGKQLED Q95260 32 0 -
DKEGIPPDQQRLIFAGKQLED Q63446 32 0 -
DKEGIPPDQQRLIFAGKQLED Q63429 32 0 -
DKEGIPPDQQRLIFAGKQLED Q62317 32 0 -
DKEGIPPDQQRLIFAGKQLED Q60507 32 0 -
DKEGIPPDQQRLIFAGKQLED Q17033 32 0 -
DKEGIPPDQQRLIFAGKQLED Q17000 32 0 -
DKEGIPPDQQRLIFAGKQLED O46543 108 0 -
DKEGIPPDQQRLIFAGKQLED O35080 32 0 -
DKEGIPPDQQRLIFAGKQLED O04829 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_SOYBN 32 0 -
DKEGIPPDQQRLIFAGKQLED Q42415 32 0 -
DKEGIPPDQQRLIFAGKQLED Q42397 32 0 -
DKEGIPPDQQRLIFAGKQLED Q41754 32 0 -
DKEGIPPDQQRLIFAGKQLED Q41753 32 0 -
DKEGIPPDQQRLIFAGKQLED Q41752 32 0 -
DKEGIPPDQQRLIFAGKQLED Q41751 32 0 -
DKEGIPPDQQRLIFAGKQLED Q41570 32 0 -
DKEGIPPDQQRLIFAGKQLED Q41411 32 0 -
DKEGIPPDQQRLIFAGKQLED Q41067 32 0 -
DKEGIPPDQQRLIFAGKQLED Q40641 32 0 -
DKEGIPPDQQRLIFAGKQLED Q40596 32 0 -
DKEGIPPDQQRLIFAGKQLED Q40164 32 0 -
DKEGIPPDQQRLIFAGKQLED Q39257 32 0 -
DKEGIPPDQQRLIFAGKQLED Q38875 32 0 -
DKEGIPPDQQRLIFAGKQLED P93501 134 0 -
DKEGIPPDQQRLIFAGKQLED P93135 32 0 -
DKEGIPPDQQRLIFAGKQLED O80715 32 0 -
DKEGIPPDQQRLIFAGKQLED O65332 32 0 -
DKEGIPPDQQRLIFAGKQLED O49906 32 0 -
DKEGIPPDQQRLIFAGKQLED O24122 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_CAEEL 32 0 -
DKEGIPPDQQRLIFAGKQLED O13697 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_YEAST 32 0 -
DKEGIPPDQQRLIFAGKQLED O74819 32 0 -
DKEGIPPDQQRLIFAGKQLED O74295 32 0 -
DKEGIPPDQQRLIFAGKQLED O74274 32 0 -
DKEGIPPDQQRLIFAGKQLED O60036 32 0 -
DKEGIPPDQQRLIFAGKQLED O59964 32 0 -
DKEGIPPDQQRLIFAGKQLED O59963 32 0 -
DKEGIPPDQQRLIFAGKQLED O59962 32 0 -
DKEGIPPDQQRLIFAGKQLED O49905 32 0 -
DKEGIPPDQQRLIFAGKQLED O14257 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_NEUCR 32 0 -
DKEGIPPDQQRLIFAGKQLED Q39926 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_AGLNE 32 0 -
DKEGIPPDQQRLIFAGKQLED O49907 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_ACACA 32 0 -
DKEGIPPDQQRLIFAGKQLED Q25400 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_EIMBO 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_TRYCR 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_STRPU 32 0 -
DKQGIPPDQQRLIFAGKQLED Q17001 32 0 -
DKEGIPPDQQRLIFAGKQLED P93379 32 0 -
DKEGIPPDQQRLIFAGKQLED O42388 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_TETPY 32 0 -
DKEGIPPDQQRLIFAGKQLED P90616 32 0 -
DKEGIPPDQQRLIFAGKQLED O00945 108 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_DICDI 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_ACECL 32 0 -
DKEGIPPDQQRLIFAGKQLED Q93116 32 0 -
DKEGIPPDQQRLIFAGKQLED Q24903 32 0 -
DKEGIPPDQQRLIFAGKQLEE Q25422 32 0 -
DKEGIPPDQQRLIFAGKQLEE Q25426 32 0 -
DKEGIPPDQQRLIFAGKQLEE UBIQ_LEIMA 32 0 -
DKEGIPPDQQRLIFAGKQLED Q65815 1622 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_EUPEU 32 0 -
DKEGIPPDQQRLIFAGKQLEE UBIQ_TRYBB 32 0 -
DKEGIPPDQQRLIFAGKQLED UBIQ_PHYIN 32 0 -
DKEGIPPDQQRLIFAGKQLED Q27191 260 0 -
DKEGIPPDQQRLIFAGKQLED Q27196 108 0 -
DKEGIPPDQQRLIFAGKQLED O46314 32 0 -
DKEGIPPDQQRLIFADKQLEE UBIQ_LEITA 32 0 -
DKEGILPRQQRLIFAGKQLED Q39256 110 0 -
DKEGIPSDQQRLIFAGKQLED Q27192 260 0 -
EKEGIPPDQQRLIFAGKQLEE Q27935 32 0 -
DKEGIPSDQQRLIFAGKQLED Q27194 108 0 -
DKEGIPPDQQRLIYAGKQLED Q90195 32 0 -
DKEGVPVDQQRLIYAGKQLED UBIL_NPVOP 32 0 -
DKEGVPVDQQRLIFAGKQLED UBIL_NPVAC 32 0 -
DKESIPPDELRFIFAGKFLEE Q27195 108 0 -
EKEGIPPPQQRLIFAGKQMND Q93725 32 0 -
EKEGIPPQQQRLIYSGKQMND NED8_MOUSE 32 0 -
EKEGIPPQQQRLIYSGKQMND NED8_HUMAN 32 0 -
EKEGIPPVHQRIVYTGKQLAD O65381 32 0 -
NKHGVPPDQQRLIFGRAQLEN O44819 192 0 -
EKEGIPPSQQRLIYAGKQMAD O14399 32 0 -
RLEGIPVAQQHLIWNNMELED Q91890 59 0 -
RLEGIPVAQQHLIRNNMELED Q91889 59 0 -
ARQHVPVEQQRLTYETKELEN O13256 421 0 -
TKTGIIPETQIVTCNGKRLED O15205 121 0 -

Motif 3 width=22
Element Seqn Id St Int Rpt
GRTLSDYNIQKESTLHLVLRLR O60010 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_COPCO 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q92332 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q01867 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q00811 53 0 -
GRTLSDYNIQKESTLHLVLRLR O74216 53 0 -
GRTLADYNIQKESTLHLVLRLR Q41646 53 0 -
GRTLADYNIQKESTLHLVLRLR UBIQ_CHLRE 53 0 -
GRTLSDYNIQKESTLHLVLRLR O35079 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_HUMAN 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q95260 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q63446 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q63429 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q62317 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q60507 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q17033 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q17000 53 0 -
GRTLSDYNIQKESTLHLVLRLR O46543 129 0 -
GRTLSDYNIQKESTLHLVLRLR O35080 53 0 -
GRTLADYNIQKESTLHLVLRLR O04829 53 0 -
GRTLADYNIQKESTLHLVLRLR UBIQ_SOYBN 53 0 -
GRTLADYNIQKESTLHLVLRLR Q42415 53 0 -
GRTLADYNIQKESTLHLVLRLR Q42397 53 0 -
GRTLADYNIQKESTLHLVLRLR Q41754 53 0 -
GRTLADYNIQKESTLHLVLRLR Q41753 53 0 -
GRTLADYNIQKESTLHLVLRLR Q41752 53 0 -
GRTLADYNIQKESTLHLVLRLR Q41751 53 0 -
GRTLADYNIQKESTLHLVLRLR Q41570 53 0 -
GRTLADYNIQKESTLHLVLRLR Q41411 53 0 -
GRTLADYNIQKESTLHLVLRLR Q41067 53 0 -
GRTLADYNIQKESTLHLVLRLR Q40641 53 0 -
GRTLADYNIQKESTLHLVLRLR Q40596 53 0 -
GRTLADYNIQKESTLHLVLRLR Q40164 53 0 -
GRTLADYNIQKESTLHLVLRLR Q39257 53 0 -
GRTLADYNIQKESTLHLVLRLR Q38875 53 0 -
GRTLADYNIQKESTLHLVLRLR P93501 155 0 -
GRTLADYNIQKESTLHLVLRLR P93135 53 0 -
GRTLADYNIQKESTLHLVLRLR O80715 53 0 -
GRTLADYNIQKESTLHLVLRLR O65332 53 0 -
GRTLADYNIQKESTLHLVLRLR O49906 53 0 -
GRTLADYNIQKESTLHLVLRLR O24122 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_CAEEL 53 0 -
GRTLSDYNIQKESTLHLVLRLR O13697 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_YEAST 53 0 -
GRTLSDYNIQKESTLHLVLRLR O74819 53 0 -
GRTLSDYNIQKESTLHLVLRLR O74295 53 0 -
GRTLSDYNIQKESTLHLVLRLR O74274 53 0 -
GRTLSDYNIQKESTLHLVLRLR O60036 53 0 -
GRTLSDYNIQKESTLHLVLRLR O59964 53 0 -
GRTLSDYNIQKESTLHLVLRLR O59963 53 0 -
GRTLSDYNIQKESTLHLVLRLR O59962 53 0 -
GRTLSDYNIQKESTLHLVLRLR O49905 53 0 -
GRTLSDYNIQKESTLHLVLRLR O14257 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_NEUCR 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q39926 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_AGLNE 53 0 -
GRTLADYNIQKESTLHLVLRLR O49907 53 0 -
GRTLADYNIQKESTLHLVLRLR UBIQ_ACACA 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q25400 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_EIMBO 53 0 -
GRTLADYNIQKESTLHLVLRLR UBIQ_TRYCR 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_STRPU 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q17001 53 0 -
GRTLADYNIQKESTRHLVLRLR P93379 53 0 -
GRTLADYNIQKESTLHLVLRLR O42388 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_TETPY 53 0 -
GRTLSDYNIQKESTLHLVLRLR P90616 53 0 -
GRTLSDYNIQKESTLHLVLRLR O00945 129 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_DICDI 53 0 -
GRTLADYNIQKESTLHLVLRLR UBIQ_ACECL 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q93116 53 0 -
RRTLSDYNIQKESTLHLVLRLR Q24903 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q25422 53 0 -
GRTLSDYNIQKESTLHLVLRLR Q25426 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_LEIMA 53 0 -
GRSLSDYNIQKESTLHLVLRLR Q65815 1643 0 -
GRTLADYNIQKESTLHLVLRLR UBIQ_EUPEU 53 0 -
GRTLADYNIQKESTLHLVLRLR UBIQ_TRYBB 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_PHYIN 53 0 -
GRTVSDYNIQKESTLHLVLRLR Q27191 281 0 -
GRTISDYNIQKESTLHLVLRLR Q27196 129 0 -
GRSLSDYNIQKESTLHLVLRLR O46314 53 0 -
GRTLSDYNIQKESTLHLVLRLR UBIQ_LEITA 53 0 -
GRTLADYNIQKESTLHLVLRLC Q39256 131 0 -
GRTVSDYNIQKESTLHLVLRLR Q27192 281 0 -
GKTLSDYNIQKESTLHLVLRLR Q27935 53 0 -
ERTVSDYNIQKESTLHLVLRLR Q27194 129 0 -
TRTMSDYNIQKESTIHLVLRLR Q90195 53 0 -
AQTLADYNIQKESTLHMVLRLR UBIL_NPVOP 53 0 -
SKTMADYNIQKESTLHMVLRLR UBIL_NPVAC 53 0 -
ERTLSDLNIQKENTLHLVLIRV Q27195 129 0 -
DKTAADYKVLGGSVLHLVLALR Q93725 53 0 -
EKTAADYKILGGSVLHLVLALR NED8_MOUSE 53 0 -
EKTAADYKILGGSVLHLVLALR NED8_HUMAN 53 0 -
DLTAKHYNLERGSVLHLVLALR O65381 53 0 -
DRALFAYNIRDEDIIHLVSRHR O44819 213 0 -
DKNAESYHLEGGSVLHLVLALR O14399 53 0 -
ECSLSDYNISEGCTLKMVLAMR Q91890 80 0 -
ECSLSGYNISEGCTLKMVLAMR Q91889 80 0 -
HHTLEHYHVQPRSTIYLLLRLR O13256 442 0 -
GKMMADYGIRKGNLLFLASYCI O15205 142 0 -