1. HIMMLER, A., HAUPTMANN, R., ADOLF, G.R. AND SWETLY, P.
Molecular cloning and expression in Escherichia coli of equine type I
DNA 5(5) 345-356 (1986).
2. LAWN, R.M., GROSS, M., HOUCK, C.M., FRANKE, A.E., GRAY, P.V. AND
DNA sequence of a major human leukocyte interferon gene.
PROC.NATL.ACAD.SCI.U.S.A. 78(9) 5435-5439 (1981).
Interferons produce antiviral and antiproliferative responses in cells, and
are defined by their ability to confer viral resistance to their target
cell . Type I interferons can be divided into alpha, beta and omega
(alpha-II) subtypes, depending on their sequence: these sequence
differences may possibly cause different responses to various inducers, or
result in the recognition of different target cell types . The main
conserved structural feature of interferons is a disulphide bond that,
except in mouse beta interferon, occurs in all alpha, beta and omega
INTERFERONAB is a 3-element fingerprint that provides a signature for alpha,
beta and omega interferons. The fingerprint was derived from an initial
alignment of 14 sequences: motifs 1 and 3 each contain one of the Cys
residues involved in disulphide bond formation, motif 3 including the
region encoded by PROSITE pattern INTERFERON_ALPHABETA (PS00252). Two
iterations on OWL22.1 were required to reach convergence, at which point a
true set comprising 93 sequences was identified.
An update on SPTR37_9f identified a true set of 92 sequences.