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PR00266

Identifier
INTERFERONAB  [View Relations]  [View Alignment]  
Accession
PR00266
No. of Motifs
3
Creation Date
15-JAN-1994  (UPDATE 07-JUN-1999)
Title
Interferon alpha and beta subunit signature
Database References

PROSITE; PS00252 INTERFERON_A_B_D
PFAM; PF00143 interferon
INTERPRO; IPR000471
PDB; 2HIE
SCOP; 2HIE
Literature References
1. HIMMLER, A., HAUPTMANN, R., ADOLF, G.R. AND SWETLY, P.
Molecular cloning and expression in Escherichia coli of equine type I
interferons.
DNA 5(5) 345-356 (1986).
 
2. LAWN, R.M., GROSS, M., HOUCK, C.M., FRANKE, A.E., GRAY, P.V. AND
GOEDDEL, D.V.
DNA sequence of a major human leukocyte interferon gene.
PROC.NATL.ACAD.SCI.U.S.A. 78(9) 5435-5439 (1981).

Documentation
Interferons produce antiviral and antiproliferative responses in cells, and
are defined by their ability to confer viral resistance to their target
cell [1]. Type I interferons can be divided into alpha, beta and omega
(alpha-II) subtypes, depending on their sequence: these sequence
differences may possibly cause different responses to various inducers, or 
result in the recognition of different target cell types [2]. The main
conserved structural feature of interferons is a disulphide bond that, 
except in mouse beta interferon, occurs in all alpha, beta and omega
sequences.
 
INTERFERONAB is a 3-element fingerprint that provides a signature for alpha,
beta and omega interferons. The fingerprint was derived from an initial 
alignment of 14 sequences: motifs 1 and 3 each contain one of the Cys
residues involved in disulphide bond formation, motif 3 including the
region encoded by PROSITE pattern INTERFERON_ALPHABETA (PS00252). Two
iterations on OWL22.1 were required to reach convergence, at which point a
true set comprising 93 sequences was identified.
 
An update on SPTR37_9f identified a true set of 92 sequences.
Summary Information
92 codes involving  3 elements
0 codes involving 2 elements
Composite Feature Index
3929292
2000
123
True Positives
INA1_BOVIN    INA1_HORSE    INA1_HUMAN    INA1_MOUSE    
INA1_PIG INA1_RAT INA2_HORSE INA2_HUMAN
INA2_MOUSE INA3_HORSE INA4_HORSE INA4_HUMAN
INA4_MOUSE INA5_HUMAN INA5_MOUSE INA6_HUMAN
INA6_MOUSE INA7_HUMAN INA7_MOUSE INA8_HUMAN
INA8_MOUSE INA9_MOUSE INAA_BOVIN INAA_HUMAN
INAB_BOVIN INAC_BOVIN INAD_BOVIN INAD_HUMAN
INAF_BOVIN INAF_HUMAN INAG_BOVIN INAG_HUMAN
INAH_BOVIN INAK_HUMAN INA_FELCA INB1_BOVIN
INB2_BOVIN INB3_BOVIN INB_HORSE INB_HUMAN
INB_MOUSE INB_RAT IND1_HUMAN INO1_BOVIN
INO1_HORSE INO1_HUMAN INO2_HORSE O46633
O77812 P28168 P28169 P28170
P28171 P28172 P81255 Q08053
Q08070 Q08071 Q08072 Q14605
Q14607 Q14608 Q14618 Q14639
Q15943 Q28126 Q28127 Q28191
Q28545 Q28561 Q28562 Q28594
Q28595 Q28843 Q28845 Q28847
Q29084 Q29085 Q29098 Q29114
Q29115 Q29412 Q29429 Q61716
Q61718 Q61719 Q64138 Q95187
TP11_BOVIN TP12_BOVIN TP13_BOVIN TP1_SHEEP
Sequence Titles
INA1_BOVIN  INTERFERON ALPHA-1 PRECURSOR - BOS TAURUS (BOVINE). 
INA1_HORSE INTERFERON ALPHA-1 PRECURSOR - EQUUS CABALLUS (HORSE).
INA1_HUMAN INTERFERON ALPHA-1/13 PRECURSOR (INTERFERON ALPHA-D) (LEIF D) - HOMO SAPIENS (HUMAN).
INA1_MOUSE INTERFERON ALPHA-1 PRECURSOR - MUS MUSCULUS (MOUSE).
INA1_PIG INTERFERON ALPHA-1 PRECURSOR (IFN-ALPHA-1) - SUS SCROFA (PIG).
INA1_RAT INTERFERON ALPHA-1 PRECURSOR - RATTUS NORVEGICUS (RAT).
INA2_HORSE INTERFERON ALPHA-2 PRECURSOR - EQUUS CABALLUS (HORSE).
INA2_HUMAN INTERFERON ALPHA-2 PRECURSOR (INTERFERON ALPHA-A) (LEIF A) - HOMO SAPIENS (HUMAN).
INA2_MOUSE INTERFERON ALPHA-2 PRECURSOR - MUS MUSCULUS (MOUSE).
INA3_HORSE INTERFERON ALPHA-3 PRECURSOR - EQUUS CABALLUS (HORSE).
INA4_HORSE INTERFERON ALPHA-4 PRECURSOR - EQUUS CABALLUS (HORSE).
INA4_HUMAN INTERFERON ALPHA-4 PRECURSOR (INTERFERON ALPHA-4B) (INTERFERON ALPHA-M1) (INTERFERON ALPHA-76) - HOMO SAPIENS (HUMAN).
INA4_MOUSE INTERFERON ALPHA-4 PRECURSOR - MUS MUSCULUS (MOUSE).
INA5_HUMAN INTERFERON ALPHA-5 PRECURSOR (INTERFERON ALPHA-G) (LEIF G) (INTERFERON ALPHA-61) - HOMO SAPIENS (HUMAN).
INA5_MOUSE INTERFERON ALPHA-5 PRECURSOR - MUS MUSCULUS (MOUSE).
INA6_HUMAN INTERFERON ALPHA-6 PRECURSOR (INTERFERON ALPHA-K) (LEIF K) (INTERFERON ALPHA-54) - HOMO SAPIENS (HUMAN).
INA6_MOUSE INTERFERON ALPHA-6 PRECURSOR - MUS MUSCULUS (MOUSE).
INA7_HUMAN INTERFERON ALPHA-7 PRECURSOR (INTERFERON ALPHA-J1) (INTERFERON ALPHA-J) (LEIF J) - HOMO SAPIENS (HUMAN).
INA7_MOUSE INTERFERON ALPHA-7 PRECURSOR - MUS MUSCULUS (MOUSE).
INA8_HUMAN INTERFERON ALPHA-8 PRECURSOR (INTERFERON ALPHA-B2) (INTERFERON ALPHA-B) (LEIF B) - HOMO SAPIENS (HUMAN).
INA8_MOUSE INTERFERON ALPHA-8 PRECURSOR - MUS MUSCULUS (MOUSE).
INA9_MOUSE INTERFERON ALPHA-9 PRECURSOR - MUS MUSCULUS (MOUSE).
INAA_BOVIN INTERFERON ALPHA-A PRECURSOR - BOS TAURUS (BOVINE).
INAA_HUMAN INTERFERON ALPHA-10 PRECURSOR (INTERFERON ALPHA-C) (LEIF C) (INTERFERON ALPHA-6L) - HOMO SAPIENS (HUMAN).
INAB_BOVIN INTERFERON ALPHA-B PRECURSOR - BOS TAURUS (BOVINE).
INAC_BOVIN INTERFERON ALPHA-C PRECURSOR - BOS TAURUS (BOVINE).
INAD_BOVIN INTERFERON ALPHA-D PRECURSOR - BOS TAURUS (BOVINE).
INAD_HUMAN INTERFERON ALPHA-14 PRECURSOR (INTERFERON ALPHA-H) (LEIF H) (INTERFERON LAMBDA-2-H) - HOMO SAPIENS (HUMAN).
INAF_BOVIN INTERFERON ALPHA-F PRECURSOR - BOS TAURUS (BOVINE).
INAF_HUMAN INTERFERON ALPHA-16 PRECURSOR (INTERFERON ALPHA-WA) - HOMO SAPIENS (HUMAN).
INAG_BOVIN INTERFERON ALPHA-G PRECURSOR - BOS TAURUS (BOVINE).
INAG_HUMAN INTERFERON ALPHA-17 PRECURSOR (INTERFERON ALPHA-I') (INTERFERON ALPHA-T) (INTERFERON ALPHA-88) - HOMO SAPIENS (HUMAN).
INAH_BOVIN INTERFERON ALPHA-H PRECURSOR - BOS TAURUS (BOVINE).
INAK_HUMAN INTERFERON ALPHA-21 PRECURSOR (INTERFERON ALPHA-F) (LEIF F) - HOMO SAPIENS (HUMAN).
INA_FELCA INTERFERON ALPHA PRECURSOR - FELIS SILVESTRIS CATUS (CAT).
INB1_BOVIN INTERFERON BETA-1 PRECURSOR - BOS TAURUS (BOVINE).
INB2_BOVIN INTERFERON BETA-2 PRECURSOR - BOS TAURUS (BOVINE).
INB3_BOVIN INTERFERON BETA-3 PRECURSOR - BOS TAURUS (BOVINE).
INB_HORSE INTERFERON BETA PRECURSOR (IFN-BETA) - EQUUS CABALLUS (HORSE).
INB_HUMAN INTERFERON BETA PRECURSOR (IFN-BETA) (FIBROBLAST INTERFERON) - HOMO SAPIENS (HUMAN).
INB_MOUSE INTERFERON BETA PRECURSOR (IFN-BETA) - MUS MUSCULUS (MOUSE).
INB_RAT INTERFERON BETA PRECURSOR (IFN-BETA) - RATTUS NORVEGICUS (RAT).
IND1_HUMAN INTERFERON DELTA-1 PRECURSOR - HOMO SAPIENS (HUMAN).
INO1_BOVIN INTERFERON OMEGA-1 PRECURSOR (INTERFERON ALPHA-II-1) - BOS TAURUS (BOVINE).
INO1_HORSE INTERFERON OMEGA-1 PRECURSOR (INTERFERON ALPHA-II-1) - EQUUS CABALLUS (HORSE).
INO1_HUMAN INTERFERON OMEGA-1 PRECURSOR (INTERFERON ALPHA-II-1) - HOMO SAPIENS (HUMAN).
INO2_HORSE INTERFERON OMEGA-2 PRECURSOR (INTERFERON ALPHA-II-2) - EQUUS CABALLUS (HORSE).
O46633 TROPHOBLAST INTERFERON PRECURSOR - CERVUS ELAPHUS (RED DEER).
O77812 INTERFERON BETA - MACACA FASCICULARIS (CRAB EATING MACAQUE) (CYNOMOLGUS MONKEY).
P28168 TROPHOBLAST PROTEIN-1 - OVIS ARIES (SHEEP).
P28169 TROPHOBLAST PROTEIN-1 PRECURSOR (TP-1) (TROPHOBLASTIN) (VERSION 2) - OVIS ARIES (SHEEP).
P28170 INTERFERON OMEGA PRECURSOR - OVIS ARIES (SHEEP).
P28171 TROPHOBLAST PROTEIN-1 PRECURSOR (TP-1) (TROPHOBLASTIN) - CAPRA HIRCUS (GOAT).
P28172 TROPHOBLAST INTERFERON - OVIS MOSCHATUS.
P81255 INTERFERON ALPHA-1 PRECURSOR - CANIS FAMILIARIS (DOG).
Q08053 TROPHOBLAST PROTEIN-1 PRECURSOR (TP-02) (TROPHOBLASTIN) - OVIS ARIES (SHEEP).
Q08070 TROPHOBLAST PROTEIN-1 PRECURSOR (TP-010) (TROPHOBLASTIN) - OVIS ARIES (SHEEP).
Q08071 TROPHOBLAST PROTEIN-1 PRECURSOR (TP-07) (TROPHOBLASTIN) - OVIS ARIES (SHEEP).
Q08072 TROPHOBLAST PROTEIN-1 PRECURSOR (TP-08) (TROPHOBLASTIN) - OVIS ARIES (SHEEP).
Q14605 INTERFERON-ALPHA 13 PRECURSOR - HOMO SAPIENS (HUMAN).
Q14607 INTERFERON-ALPHA-J1 (IFN-ALPHA-J1) - HOMO SAPIENS (HUMAN).
Q14608 LEUKOCYTE INTERFERON-ALPHA - HOMO SAPIENS (HUMAN).
Q14618 INTERFERON ALPHA-N - HOMO SAPIENS (HUMAN).
Q14639 LEUCOCYTE INTERFERON PRECURSOR - HOMO SAPIENS (HUMAN).
Q15943 INTERFERON-BETA PRECURSOR - HOMO SAPIENS (HUMAN).
Q28126 INTERFERON ALPHA II - BOS TAURUS (BOVINE).
Q28127 INTERFERON-1 - BOS TAURUS (BOVINE).
Q28191 TROPHOBLAST TYPE I INTERFERON GENE PRECURSOR - BOS TAURUS (BOVINE).
Q28545 INTERFERON TYPE I PRECURSOR - OVIS ARIES (SHEEP).
Q28561 INTERFERON ALPHA PRECURSOR - OVIS ARIES (SHEEP).
Q28562 OVINE INTERFERON ALPHA PRECURSOR - OVIS ARIES (SHEEP).
Q28594 TROPHOBLAST PROTEIN-1 P3 PRECURSOR - OVIS ARIES (SHEEP).
Q28595 TROPHOBLAST PROTEIN-1 P5 PRECURSOR - OVIS ARIES (SHEEP).
Q28843 INTERFERON-OMEGA44 - ORYCTOLAGUS CUNICULUS (RABBIT).
Q28845 INTERFERON-OMEGA45 - ORYCTOLAGUS CUNICULUS (RABBIT).
Q28847 INTERFERON-OMEGA20 - ORYCTOLAGUS CUNICULUS (RABBIT).
Q29084 POIFN-ALPHA II-4 GENE PRECURSOR - SUS SCROFA (PIG).
Q29085 POIFN-ALPHA II-5 PRECURSOR - SUS SCROFA (PIG).
Q29098 POIFN-ALPHA II-3 PRECURSOR - SUS SCROFA (PIG).
Q29114 SHORT TYPE I INTERFERON PRECURSOR - SUS SCROFA (PIG).
Q29115 SHORT TYPE I INTERFERON PRECURSOR - SUS SCROFA (PIG).
Q29412 INTERFERON-BETA-1 PRECURSOR - SUS SCROFA (PIG).
Q29429 TROPHOBLAST PROTEIN-1 P6 PRECURSOR - OVIS ARIES (SHEEP).
Q61716 INTERFERON ALPHA FAMILY, PROTEIN 11 (ALPHA-INTERFERON) - MUS MUSCULUS (MOUSE).
Q61718 ALPHA-INTERFERON PRECURSOR - MUS MUSCULUS (MOUSE).
Q61719 INTERFERON ALPHA FAMILY, PROTEIN B PRECURSOR (INTERFERON ALPHA-B) - MUS MUSCULUS (MOUSE).
Q64138 INTERFERON-ALPHA 1 - CRICETIDAE SP. (HAMSTER).
Q95187 INTERFERON TAU - GIRAFFA CAMELOPARDALIS (GIRAFFE).
TP11_BOVIN TROPHOBLAST PROTEIN-1 PRECURSOR (TP-1) (CLONE PBTP159) - BOS TAURUS (BOVINE).
TP12_BOVIN TROPHOBLAST PROTEIN-1 PRECURSOR (TP-1) (CLONE LAMBDA-BTP517) - BOS TAURUS (BOVINE).
TP13_BOVIN TROPHOBLAST PROTEIN-1 PRECURSOR (TP-1) (CLONE LAMBDA-BTP509) - BOS TAURUS (BOVINE).
TP1_SHEEP TROPHOBLAST PROTEIN-1 PRECURSOR (TP-1) (TROPHOBLASTIN) - OVIS ARIES (SHEEP).
Scan History
OWL22_1    2  100  NSINGLE    
OWL26_0 1 120 NSINGLE
SPTR37_9f 2 95 NSINGLE
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
CLQDRNDFAFPQE INAC_BOVIN 52 52 -
CLKDRMNFDIPEE INB_HUMAN 52 52 -
CLEAKMDFQVPEE INB3_BOVIN 52 52 -
CLKDRHDFGFPEE INAM_HUMAN 52 52 -
CLKDRHDFEFPQE INAB_HUMAN 52 52 -
NLTYRADFKIPME INB_MOUSE 50 50 -
CLMDRHDFGFPQE INAD_HUMAN 52 52 -
CLKDRRDFRFPQE INO1_HUMAN 52 52 -
CLQDRKDFGLPQE TP1_SHEEP 52 52 -
CLQDRKDFGLPQE TP11_BOVIN 52 52 -
CLKDRNDFGFPQE INA2_HORSE 52 52 -
CLKDRKDFGFPQE INA9_MOUSE 52 52 -
CLQDRKDFGLPQE TP13_BOVIN 52 52 -
CLKDRKDFGFPQE INA5_MOUSE 52 52 -

Motif 2 width=28
Element Seqn Id St Int Rpt
VLHEVTQHTFQLFSTEGSATMWDESLLD INAC_BOVIN 79 14 -
VLHEMIQQTFNLFSTKDSSAALDETLLD INAB_HUMAN 79 14 -
VLHEMIQQTFNLFSTEDSSAAWEQSLLE INAM_HUMAN 79 14 -
VLHELIQQIFNLFTTKDSSAAWDEDLLD INAD_HUMAN 79 14 -
VLHEMLQQIFSLFHTERSSAAWNMTLLD INO1_HUMAN 79 14 -
VLYEMLQQSFNLFYTEHSSAAWDTTLLD TP1_SHEEP 79 14 -
VLHEMLQQCFNLFYTEHSSAAWNTTLLE TP11_BOVIN 79 14 -
AVHETIQQIFHLFSTDGSSAAWDESLLD INA2_HORSE 79 14 -
VLSELTQQILTLFTSKDSSAAWNATLLD INA9_MOUSE 79 14 -
VLHEMLQQCLNLFYTEHSSAAWNTTLLE TP13_BOVIN 79 14 -
VLSELTQQVLNIFTSKDSSAAWNATLLD INA5_MOUSE 79 14 -
TIYEMLQNIFAIFRQDSSSTGWNETIVE INB_HUMAN 79 14 -
VIYEMLQQIFNILTRDFSSTGWSETIIE INB3_BOVIN 79 14 -
AIQEMLQNVFLVFRNNFSSTGWNETIVV INB_MOUSE 75 12 -

Motif 3 width=19
Element Seqn Id St Int Rpt
YLESKEYNRCAWTVVRVQI INB3_BOVIN 152 45 -
YLKLMKYNSYAWMVVRAEI INB_MOUSE 148 45 -
YLTEKKYSPCAWEVVRAEI INAD_HUMAN 153 46 -
YLTEKKYSPCAWEVVRAEI INAM_HUMAN 153 46 -
YLKEKKYSDCAWEVVRMEI INO1_HUMAN 153 46 -
YLQEKGYSDCAWEIVRVEM TP1_SHEEP 153 46 -
YLKEKEYSDCAWEIIRMEM TP11_BOVIN 153 46 -
YLQEKKYSPCAWEIVRAEI INA2_HORSE 153 46 -
YLREKKHSPCAWEVVRAEV INA9_MOUSE 153 46 -
YLKEKEYSDCAWEIIRVEM TP13_BOVIN 153 46 -
YLREKKHSPCAWEVVRAEV INA5_MOUSE 153 46 -
YLQEKRHSPCAWEVVRAQV INAC_BOVIN 153 46 -
YLTEKKYSSCAWEVVRAEI INAB_HUMAN 153 46 -
YLKAKEYSHCAWTIVRVEI INB_HUMAN 153 46 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
CLKDRHDFGFPQE INA2_HUMAN 52 52 -
CLKDRHDFGFPQE INA5_HUMAN 52 52 -
CLKDRKDFGFPQE Q29085 52 52 -
CLKDRKDFGFPQE Q29084 52 52 -
CLKDRHDFGLPQE INAG_HUMAN 52 52 -
CLKDRHDFGLPQE Q14639 52 52 -
CLMDRHDFGFPQE INAD_HUMAN 52 52 -
CLKDRHDFGFPQE INAK_HUMAN 52 52 -
CLKDRHDFGFPQE Q14608 44 44 -
CLQDRKDFAFPQE Q28561 52 52 -
CLKDRRDFRFPQE INO1_HUMAN 52 52 -
CLKDRHDFGFPEE INA4_HUMAN 52 52 -
CLQDRKDFGLPQE Q08070 52 52 -
CLQDRKDFGLPQE P28169 52 52 -
CLQDRKDFAFPQE P28170 52 52 -
CLQDRKDFGLPQE Q08072 52 52 -
CLQDRKDFGLPQE Q28594 52 52 -
CLQDRKDFGLPQE TP1_SHEEP 52 52 -
CLKDRKDFGFPQE Q29098 52 52 -
CLMDRHDFGFPQE INA1_HUMAN 52 52 -
CLMDRHDFGFPQE Q14605 52 52 -
CLQDRKDFGLPQE Q08071 52 52 -
CLQDRKDFGLPQE Q28595 52 52 -
CLQDRKDFGLPQE P28168 52 52 -
CLQDRKDFGLPQE Q08053 52 52 -
CLKDRHDFEFPQE INA8_HUMAN 52 52 -
CLQDRKDFAFPQE INO1_BOVIN 52 52 -
CLQDRKDFGLPQE Q29429 52 52 -
CLQDRKDFALPQE IND1_HUMAN 52 52 -
CLKDRYDFGFPQE INAF_HUMAN 52 52 -
CLKDRYDFGFPQE Q14618 52 52 -
CLKDRHDFRFPQE INA6_HUMAN 52 52 -
CLKDRKDFRFPQD INO2_HORSE 52 52 -
CLQDRKDFGLPQE O46633 52 52 -
CLQDRKDFGLPQE Q28126 52 52 -
CLQDRKDFGLPQE TP11_BOVIN 52 52 -
CLQDRKDFGLPQE Q28191 52 52 -
CLKDRNDFGFPQE INA1_HORSE 52 52 -
CLKDRNDFGFPQE INA2_HORSE 52 52 -
CLKDRNDFGFPQE INA3_HORSE 52 52 -
CLKDRNDFGFPQE INA4_HORSE 52 52 -
CLKDRKDFGFPQE INA9_MOUSE 52 52 -
CLKDRKDFGFPQE INA1_MOUSE 52 52 -
CLQDRKDFGLPQE Q28127 52 52 -
CLQDRKDFGLPQE TP13_BOVIN 52 52 -
CLKDRKDFGFPQE INA5_MOUSE 52 52 -
CLKDRKDFGFPQE Q61719 52 52 -
CLQDRKDFGLPQE TP12_BOVIN 52 52 -
CLKDRHDFRIPQE INAA_HUMAN 52 52 -
CQQDRKDFGLPQE P28171 52 52 -
CLKDRHEFRFPEE Q14607 52 52 -
CLKDRHEFRFPEE INA7_HUMAN 52 52 -
CLKDRKDFGFPQE INA8_MOUSE 52 52 -
CLKDRKDFGFPQE INA6_MOUSE 52 52 -
CQQDRKDFGLPQE P28172 52 52 -
CLKDRKDFRFPQE Q61718 52 52 -
CLQDRKDFGLPRK Q95187 52 52 -
CLKDRRDFQFPRE Q28545 52 52 -
CLKDRRDFQFPRE Q28562 52 52 -
CLKDRRDFQFPRE Q28845 52 52 -
CLKDRRDFQFPRE Q28847 52 52 -
CLKDRRDFQFPRE Q28843 52 52 -
CLKDRQDFGFPLE INA2_MOUSE 52 52 -
CLKDRKDFGFPQA INA7_MOUSE 52 52 -
CLKHRTDFRFPQE INO1_HORSE 52 52 -
CLQDRNDFAFPQE INAH_BOVIN 52 52 -
CLQDRNDFAFPQE INAB_BOVIN 52 52 -
CLKDRQDFGFPLE Q61716 52 52 -
CLQDRNDFAFPQE INA1_BOVIN 52 52 -
CLQDRNDFAFPQE INAC_BOVIN 52 52 -
CLQDRNDFAFPQE INAD_BOVIN 52 52 -
CLQDRNDFAFPQE INAG_BOVIN 52 52 -
CLKDRRDFAFPLE Q64138 52 52 -
CLQDRNDFEFLQE INAA_BOVIN 52 52 -
CLQDRNDFALPQE INAF_BOVIN 52 52 -
CLKDRKYFGFPLE INA1_RAT 52 52 -
CLKDRKDFGFPLE INA4_MOUSE 53 53 -
CLDHRRDFGSPHE INA1_PIG 52 52 -
CLKDRIDFKFPWK Q29115 51 51 -
CLKDRIDFKFPWK Q29114 51 51 -
CQKDRNDFAFPQD INA_FELCA 52 52 -
CLKDRMNFDIPEE INB_HUMAN 52 52 -
CLKDRMNFDIPEE O77812 52 52 -
CLKDRRNFDIPEE Q15943 52 52 -
CDHYTNDFAFPKE P81255 52 52 -
CLEARMDFQMPEE INB2_BOVIN 52 52 -
CLEDRMNFEVPEE Q29412 52 52 -
CLEAKMDFQVPEE INB3_BOVIN 52 52 -
CLEARMDFQMPEE INB1_BOVIN 52 52 -
NLSYRTDFKIPME INB_RAT 50 50 -
CPEDTMNFQVPEE INB_HORSE 52 52 -
NLTYRADFKIPME INB_MOUSE 50 50 -

Motif 2 width=28
Element Seqn Id St Int Rpt
VLHEMIQQIFNLFSTKDSSAAWDETLLD INA2_HUMAN 78 13 -
VLHEMIQQTFNLFSTKDSSATWDETLLD INA5_HUMAN 79 14 -
VLHEMLQQTFLLFHTERSSAAWDSTLLD Q29085 79 14 -
VLHEMLQQTFLLLHTERSSAAWDSTLLD Q29084 79 14 -
VLHEMIQQTFNLFSTEDSSAAWEQSLLE INAG_HUMAN 79 14 -
VLHEMIQQTFNLFSTEDSSAAWEQSLLE Q14639 79 14 -
VLHELIQQIFNLFTTKDSSAAWDEDLLD INAD_HUMAN 79 14 -
VLHEMIQQTFNLFSTKDSSATWEQSLLE INAK_HUMAN 79 14 -
VLHEMIQQTFNLFSTKDSSATWEQSLLE Q14608 71 14 -
VLHEMLQQSFNLFHTEHSSAAWDTTLLE Q28561 79 14 -
VLHEMLQQIFSLFHTERSSAAWNMTLLD INO1_HUMAN 79 14 -
VLHEMIQQTFNLFSTEDSSAAWEQSLLE INA4_HUMAN 79 14 -
VLYEMLQQTFNLFHTEHSSAAWDTTLLE Q08070 79 14 -
VLYEMLQQSFNLFHTERSSAAWNTTLLE P28169 79 14 -
VLHEMLQQSFNLFHTERSSAAWNTTLLK P28170 79 14 -
VLYEMLQQSFNLFYTEHSSAAWDTTLLD Q08072 79 14 -
VLYEMLQQSFNLFYTEHSSAAWDTTLLD Q28594 79 14 -
VLYEMLQQSFNLFYTEHSSAAWDTTLLD TP1_SHEEP 79 14 -
VLHEMLQQTFLLLHTERSSAAWDSTLLD Q29098 79 14 -
VLHELIQQIFNLFTTKDSSAAWDEDLLD INA1_HUMAN 79 14 -
VLHELIQQIFNLFTTKDSSAAWDEDLLD Q14605 79 14 -
VLYEMLQQSFNLFYTEHSSAAWDTTLLE Q08071 79 14 -
VLYEMLQQSFNLFYTEHSSAAWDTTLLE Q28595 79 14 -
VLYEMLQQSFNLFHTERSSAAWNTTLLE P28168 79 14 -
VLYEMLQQSFNLFHTERSSAAWNTTLLE Q08053 79 14 -
VLHEMIQQTFNLFSTKDSSAALDETLLD INA8_HUMAN 79 14 -
VLHEMLQQSFNLFHKERSSAAWDTTLLE INO1_BOVIN 79 14 -
VLYEMLQQSFNVFHTERSSAAWNTTLLE Q29429 79 14 -
VLHEMLQQSFNLFHTEHSSAAWDTTLLE IND1_HUMAN 79 14 -
AFHEMIQQTFNLFSTKDSSAAWDETLLD INAF_HUMAN 79 14 -
AFHEMIQQTFNLFSTKDSSAAWDETLLD Q14618 79 14 -
VLHEVIQQTFNLFSTKDSSVAWDERLLD INA6_HUMAN 79 14 -
VLHEMLQQIFSLFHTERSSAAWNTTLLD INO2_HORSE 79 14 -
VLHEMLQQCFNLFHTERSSAAWDTTLLE O46633 79 14 -
VLHEMLQQCFNLFYTEHSSAAWNTTLLE Q28126 79 14 -
VLHEMLQQCFNLFYTEHSSAAWNTTLLE TP11_BOVIN 79 14 -
VLHEMLQQCFNLFYTEHSSAAWNTTLLE Q28191 79 14 -
AVHETIQQIFHLFSTDGSSAAWDESLLD INA1_HORSE 79 14 -
AVHETIQQIFHLFSTDGSSAAWDESLLD INA2_HORSE 79 14 -
AVHETIQQIFHLFSTDGSSAAWDESLLD INA3_HORSE 79 14 -
AVHETIQQIFHLFSTDGSSAAWDESLLD INA4_HORSE 79 14 -
VLSELTQQILTLFTSKDSSAAWNATLLD INA9_MOUSE 79 14 -
VLSELTQQILNIFTSKDSSAAWNATLLD INA1_MOUSE 79 14 -
VLHEMLQQCLNLFYTEHSSAAWNTTLLE Q28127 79 14 -
VLHEMLQQCLNLFYTEHSSAAWNTTLLE TP13_BOVIN 79 14 -
VLSELTQQVLNIFTSKDSSAAWNATLLD INA5_MOUSE 79 14 -
VLTELTQQMLTLFTSKASSAAWNATLLD Q61719 79 14 -
LLHEMLQQCFNLFYTEHSSAAWNTTLLE TP12_BOVIN 79 14 -
VLHEMIQQTFNLFSTEDSSAAWEQSLLE INAA_HUMAN 79 14 -
VLYEMLQQSFNLFYTEHSSAAWDTTLLD P28171 79 14 -
VLHEMIQQTFNLFSTEDSSAAWEQSLLE Q14607 79 14 -
VLHEMIQQTFNLFSTEDSSAAWEQSLLE INA7_HUMAN 79 14 -
VLTELTQQILALFTSKDSSAAWNATLLD INA8_MOUSE 79 14 -
VLTELTQQILTLFTSKDSSAAWNATLLD INA6_MOUSE 79 14 -
VLYEMLQQRFNLFHTEHSCAAWNTTLLE P28172 79 14 -
VLQELTQQVLNIFTSKDSSAAWDASLLD Q61718 79 14 -
VLHEMLQQCFNLFHTERSSAAWDNTLLE Q95187 79 14 -
VLHEMLQQIFNLLHTARSSAAWNNTLLE Q28545 79 14 -
VLHEMLQQIFNLLHTARSSAAWNNTLLE Q28562 79 14 -
VLHEMLQQIFNLLHTARSSAAWNNTLLE Q28845 79 14 -
VLHEMLQQIFNLLHTARSSAAWNNTLLE Q28847 79 14 -
VLHEMLQQLFNLLHTARSSAAWNNTLLE Q28843 79 14 -
VLRDLTQQTLNLFTSKASSAAWNATLLD INA2_MOUSE 79 14 -
VLSELTQQILNIFTSKDSSAAWNATLLD INA7_MOUSE 79 14 -
VLQEMLQQIVSLFHTERSSAAWNTTLLD INO1_HORSE 79 14 -
VLHEVTQHTFQLFSTEGSAAAWDESLLD INAH_BOVIN 79 14 -
VLHEVTQHTFQLFSTEGSATTWDESLLD INAB_BOVIN 79 14 -
VLRDLTQQILNLFTSKASSAAWNATLLD Q61716 79 14 -
VLHEVTQHTFQLFSTEGSAAVWDESLLD INA1_BOVIN 79 14 -
VLHEVTQHTFQLFSTEGSATMWDESLLD INAC_BOVIN 79 14 -
VLHEVTQHTFQLSSTEGSAAVWDESLLD INAD_BOVIN 79 14 -
VLHEVTQHTFQFFSVEGSAVVWDESLLD INAG_BOVIN 79 14 -
LLQELTQQVLILFSSKDSSAAWETTLLD Q64138 79 14 -
VLHEVTQHTFQLFSTEGSPATWDKSLLD INAA_BOVIN 79 14 -
VLHEVTQHTSQLFSTEGFGAVWDESLLD INAF_BOVIN 79 14 -
VLHELTQQILSLFTSKESSTAWDATLLD INA1_RAT 79 14 -
VLRDLTQQILNLFTSKDLSATWNATLLD INA4_MOUSE 80 14 -
LVHEMLQQTFQLFSTEGSAAAWNESLLH INA1_PIG 79 14 -
YCYLMLQQISGVFSKKDSRAAWNTTLLD Q29115 78 14 -
YCYLMLQQISSVFSKKDSRAAWNNTLLD Q29114 78 14 -
VVHVTNQKIFHFFCTEASSSAAWNTTLL INA_FELCA 79 14 -
TIYEMLQNIFAIFRQDSSSTGWNETIVE INB_HUMAN 79 14 -
TIYEMLQNIYAIFRQDLSSTGWNETIVE O77812 79 14 -
TIYEMLQNIFAIFRQDSSSTGWNETIVE Q15943 79 14 -
VVHVMTQKVFHLFCPDTSSAPWNMTLLE P81255 79 14 -
VIYEMLQQIFNILTRDFSSTGWSETIIE INB2_BOVIN 79 14 -
IIHEMLQQIFGILRRNFSSTGWNETVIK Q29412 79 14 -
VIYEMLQQIFNILTRDFSSTGWSETIIE INB3_BOVIN 79 14 -
VMYEVLQHIFGILTRDFSSTGWSETIIE INB1_BOVIN 79 14 -
AIQVMLQNVFLVFRSNFSSTGWNETIVE INB_RAT 77 14 -
VIYEMLQHTWRIFRRNFASTGWNETIVK INB_HORSE 79 14 -
AIQEMLQNVFLVFRNNFSSTGWNETIVV INB_MOUSE 75 12 -

Motif 3 width=19
Element Seqn Id St Int Rpt
YLKEKKYSPCAWEVVRAEI INA2_HUMAN 152 46 -
YLTEKKYSPCAWEVVRAEI INA5_HUMAN 153 46 -
YLKEKKYSDCAWETVRVEI Q29085 148 41 -
YLKEKKYSDCAWEIVRVEI Q29084 148 41 -
YLTEKKYSPCAWEVVRAEI INAG_HUMAN 153 46 -
YLTEKKYSPCAWEVVRAEI Q14639 153 46 -
YLTEKKYSPCAWEVVRAEI INAD_HUMAN 153 46 -
YLTEKKYSPCAWEVVRAEI INAK_HUMAN 153 46 -
YLTEKKYSPCAWEVVRAEI Q14608 145 46 -
YLKEKGYSDCAWEIVRLEI Q28561 153 46 -
YLKEKKYSDCAWEVVRMEI INO1_HUMAN 153 46 -
YLTEKKYSPCAWEVVRAEI INA4_HUMAN 153 46 -
YLQEKGYSDCAWEIVRVEM Q08070 153 46 -
YLKEKEYSDCAWEIVRVEM P28169 153 46 -
YLKEKGYSDCAWETVRVEI P28170 153 46 -
YLQEKGYSDCAWEIVRVEM Q08072 153 46 -
YLQEKGYSDCAWEIVRVEM Q28594 153 46 -
YLQEKGYSDCAWEIVRVEM TP1_SHEEP 153 46 -
YLKEKIYSDCAWETVRVEI Q29098 148 41 -
YLTEKKYSPCAWEVVRAEI INA1_HUMAN 153 46 -
YLTEKKYSPCAWEVVRAEI Q14605 153 46 -
YLQEKGYSDCAWEIVRVEM Q08071 153 46 -
YLQEKGYSDCAWEIVRVEM Q28595 153 46 -
YLQEKGYSDCAWETVRVEM P28168 153 46 -
YLQEKGYSDCAWETVRVEM Q08053 153 46 -
YLTEKKYSSCAWEVVRAEI INA8_HUMAN 153 46 -
YLQEKGYSDCAWEIVRLEI INO1_BOVIN 153 46 -
YLQEKGYSDCAWEIVRVEM Q29429 153 46 -
YLKEKGYSDCAWETVRLEI IND1_HUMAN 153 46 -
YLMGKKYSPCAWEVVRAEI INAF_HUMAN 153 46 -
YLMGKKYSPCAWEVVRAEI Q14618 153 46 -
YLTEKKYSPCAWEVVRAEI INA6_HUMAN 153 46 -
YLKEKKYSDCAWEIVRMEI INO2_HORSE 153 46 -
YLQEKEYSDCAWEIVQVEM O46633 153 46 -
YLKEKEYSDCAWEIIRMEM Q28126 153 46 -
YLKEKEYSDCAWEIIRMEM TP11_BOVIN 153 46 -
YLKEKEYSDCAWEIIRMEM Q28191 153 46 -
YLQEKKYSPCAWEIVRAEI INA1_HORSE 153 46 -
YLQEKKYSPCAWEIVRAEI INA2_HORSE 153 46 -
YLQEKKYSPCAWEIVRAEI INA3_HORSE 153 46 -
YLQEKKYSPCAWEIVRAEI INA4_HORSE 153 46 -
YLREKKHSPCAWEVVRAEV INA9_MOUSE 153 46 -
YLREKKHSPCAWEVVRAEV INA1_MOUSE 153 46 -
YLKEKEYSDCAWEIIRVEM Q28127 153 46 -
YLKEKEYSDCAWEIIRVEM TP13_BOVIN 153 46 -
YLREKKHSPCAWEVVRAEV INA5_MOUSE 153 46 -
YLREKKHSPCAWEVVRAEV Q61719 153 46 -
YLKEKEYSDCAWEIIRMEM TP12_BOVIN 153 46 -
YLIERKYSPCAWEVVRAEI INAA_HUMAN 153 46 -
YLQEKGYSDCAWETVRVEM P28171 153 46 -
YLTEKKYSPCAWEVVRAEI Q14607 153 46 -
YLMEKKYSPCAWEVVRAEI INA7_HUMAN 153 46 -
FLREKKHSPCAWEVVRAEV INA8_MOUSE 153 46 -
FLREKKHSPCAWEVVRAEV INA6_MOUSE 153 46 -
YLQEKGYSDCAWEIVRVEM P28172 153 46 -
YLREKKHSPCAWEVVRAEV Q61718 153 46 -
YLKEKKYSDCAWEVIRVEM Q95187 153 46 -
YLDEKKHSGCAWELVRMEI Q28545 153 46 -
YLDEKKHSGCAWELVRMEI Q28562 153 46 -
YLDEKKHSGCAWELVRMEI Q28845 153 46 -
YLDEKKHSGCAWELVRMEI Q28847 153 46 -
YLDEKKHSGCAWELVRMEI Q28843 153 46 -
YLREKKHSPCAWEVVRAEV INA2_MOUSE 153 46 -
FLREKKHSPCAWEVVRAEI INA7_MOUSE 153 46 -
YLTEKKYSDCAWEIVRVDI INO1_HORSE 153 46 -
YLREKRHNPCAWEVVRAEV INAH_BOVIN 153 46 -
YLQEKRHSPCAWEVVRAEV INAB_BOVIN 153 46 -
FLREKKHSPCAWEVVRAEV Q61716 153 46 -
YLQEKRHSPCAWEVVRAQV INA1_BOVIN 153 46 -
YLQEKRHSPCAWEVVRAQV INAC_BOVIN 153 46 -
YLQEKRHSPCAWEVVRAQV INAD_BOVIN 153 46 -
YLQEKRHSPCAWEVVRAEV INAG_BOVIN 153 46 -
YLREKNHSPCAWEVVRTEV Q64138 153 46 -
YLQEKRHSPCAWEVVRAEV INAA_BOVIN 153 46 -
YLQEKRHSPCAWEVVRAEV INAF_BOVIN 153 46 -
YLRENKHSPCAWEVVKAEV INA1_RAT 153 46 -
YLRKKKHSLCAWEVIRAEV INA4_MOUSE 149 41 -
YLQEKSYSPCAWEIVRAEV INA1_PIG 153 46 -
YLKEKKYSPCAWEIVRVEI Q29115 145 39 -
YLKEKKYSPCAWEIVRVEI Q29114 145 39 -
YLQEKKYSPCAWEIVRAEI INA_FELCA 157 50 -
YLKAKEYSHCAWTIVRVEI INB_HUMAN 153 46 -
YLKAKEYSHCAWTIVRVEI O77812 153 46 -
YLKAKEDSHCAWTIVRVEI Q15943 153 46 -
YLQDRNHSPCAWEMVRAEI P81255 151 44 -
YLKSKEYNRCAWTVVRVQI INB2_BOVIN 152 45 -
YLKSKEYRSCAWTVVQVEI Q29412 152 45 -
YLESKEYNRCAWTVVRVQI INB3_BOVIN 152 45 -
YLESKEYDRCAWTVVQVQI INB1_BOVIN 152 45 -
YLKDKKYNSYAWMVVRAEV INB_RAT 150 45 -
YLKAKKYSHCAWTVVQAEM INB_HORSE 152 45 -
YLKLMKYNSYAWMVVRAEI INB_MOUSE 148 45 -