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PR00044

Identifier
LEUZIPPRMYC  [View Relations]  [View Alignment]  
Accession
PR00044
No. of Motifs
6
Creation Date
29-APR-1993  (UPDATE 28-JUL-1999)
Title
Myc proto-oncogene signature
Database References

PROSITE; PS00038 HELIX_LOOP_HELIX; PS00029 LEUCINE_ZIPPER
PFAM; PF01056 Myc_N_term
INTERPRO; IPR002418
Literature References
1. KAYE, F., BATTEY, Y., NAU, M., BROOKS, B., SEIFTER, E., DEGREVE, J., 
BIRRER, M., SAUSVILLE, E. AND MINNA, J.
Structure and expression of the human L-myc gene reveal a complex pattern
of alternative messenger RNA processing.
MOL.CELL.BIOL. 8(1) 186-195 (1988).
 
2. STEWART, M.A., FORREST, D., MCFARLANE, R., ONIONS, D., WILKIE, N. AND
NEIL, J.C.
Conservation of the C-myc coding sequence in transduced feline v-myc genes.
VIROLOGY 154(1) 121-134 (1986).
 
3. COLLUM, R.G., CLAYTON, D.F. AND ALT, F.W.
Structure and expression of canary myc family genes.
MOL.CELL.BIOL. 11(3) 1770-1776 (1991).

Documentation
The myc oncogene gene was first discovered in small-cell lung cancer cell 
lines where it is found to be deregulated [1]. Although the biochemical 
function of the gene product is unknown, as a nuclear protein with a 
short half-life it may play a direct or indirect role in controlling gene 
expression [2]. Three types of gene product have been identified, C-myc, 
L-myc and N-myc, C-myc being widely distributed and L-myc being expressed 
selectively in foetal lung, brain and kidney, and in adult lung. Temporal
and cell-specific expression of L-myc and N-myc is important in mammalian
development [2]. The myc gene product is found in high concentrations in
mammalian embryos, suggesting a role in embryogenesis. Sequence analysis
of N-myc has revealed 9 conserved regions with divergent intervening
sequences [3], 2 of the conserved motifs being specific to N-myc.
 
The myc oncogenes belong to a family of eukaryotic sequence-specific DNA-
binding proteins that share a conserved domain of around 50-60 amino acids.
This domain is thought to form a `helix-loop-helix' motif, in which 2
amphipathic helices are joined by a variable length linker. This putative
DNA-binding domain is immediately preceded by a short leucine zipper.
 
The `leucine zipper' is a structure that is believed to mediate the
function of several eukaryotic gene regulatory proteins. The zipper
consists of a periodic repetition of leucine residues at every seventh
position, and regions containing them appear to span 8 turns of alpha-
helix. The leucine side chains that extend from one helix interact with
those from a similar helix, hence facilitating dimerisation in the form
of a coiled-coil. Leucine zippers are present in many gene regulatory
proteins, including the CREB proteins, Jun/AP1 transcription factors,
fos oncogene and fos-related proteins, C-myc, L-myc and N-myc oncogenes,
and so on.
 
LEUZIPPRMYC is a 6-element fingerprint that provides a signature for the 
leucine zipper and putative helix-loop-helix DNA-binding domains of myc 
transforming proteins. The fingerprint was derived from an initial
alignment of 6 sequences: motif 5 encodes the leucine zipper region, while
motif 6 spans the helix-loop-helix domain (cf. PROSITE patterns LEUCINE_
ZIPPER (PS00029) and HELIX_LOOP_HELIX (PS00038)). Two iterations on OWL19.1
were required to reach convergence, at which point a true set comprising
40 sequences was identified. Six partial matches were also found: 4 of
these are myc proto-oncogene protein fragments; the other 2 are much
shorter, related sequences (MAX_HUMAN and MYN_MOUSE) that match motifs
5 and 6.
 
An update on SPTR37_9f identified a true set of 45 sequences, and 12
partial matches.
Summary Information
  45 codes involving  6 elements
2 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
10 codes involving 2 elements
Composite Feature Index
6454545454545
5121222
4000000
3000000
2220088
123456
True Positives
MYC1_CYPCA    MYC1_XENLA    MYC2_CYPCA    MYC2_MARMO    
MYC2_SPEBE MYC2_XENLA MYCL_HUMAN MYCL_MOUSE
MYCL_XENLA MYCM_HUMAN MYCM_XENLA MYCN_CHICK
MYCN_HUMAN MYCN_MARMO MYCN_MOUSE MYCN_RAT
MYCN_SERCA MYCN_XENLA MYCS_RAT MYC_AVIM2
MYC_AVIMC MYC_AVIMD MYC_AVIME MYC_AVIOK
MYC_BRARE MYC_CALJA MYC_CANFA MYC_CARAU
MYC_CHICK MYC_FELCA MYC_FLVTT MYC_HUMAN
MYC_HYLLA MYC_MARMO MYC_MOUSE MYC_PANTR
MYC_PIG MYC_RAT MYC_SHEEP O43372
O56221 Q85456 Q85523 Q91421
Q98927
True Positive Partials
Codes involving 5 elements
Q26649 Q67004
Codes involving 2 elements
MAX_BRARE MAX_CHICK MAX_HUMAN MAX_MOUSE
MAX_RAT MAX_XENLA P91664 Q14803
Q14897 Q14900
Sequence Titles
MYC1_CYPCA  MYC I PROTEIN (C-MYC I) - CYPRINUS CARPIO (COMMON CARP). 
MYC1_XENLA MYC I PROTEIN (C-MYC I) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
MYC2_CYPCA MYC II PROTEIN (C-MYC II) - CYPRINUS CARPIO (COMMON CARP).
MYC2_MARMO N-MYC 2 PROTO-ONCOGENE PROTEIN - MARMOTA MONAX (WOODCHUCK).
MYC2_SPEBE N-MYC 2 PROTO-ONCOGENE PROTEIN - SPERMOPHILUS BEECHEYI (BEECHEY GROUND SQUIRREL).
MYC2_XENLA MYC II PROTEIN (C-MYC II) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
MYCL_HUMAN L-MYC-1 PROTO-ONCOGENE PROTEIN - HOMO SAPIENS (HUMAN).
MYCL_MOUSE L-MYC PROTO-ONCOGENE PROTEIN - MUS MUSCULUS (MOUSE).
MYCL_XENLA L-MYC 1 PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
MYCM_HUMAN L-MYC-2 PROTEIN - HOMO SAPIENS (HUMAN).
MYCM_XENLA L-MYC 2 PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
MYCN_CHICK N-MYC PROTO-ONCOGENE PROTEIN - GALLUS GALLUS (CHICKEN).
MYCN_HUMAN N-MYC PROTO-ONCOGENE PROTEIN - HOMO SAPIENS (HUMAN).
MYCN_MARMO N-MYC PROTO-ONCOGENE PROTEIN (N-MYC1) - MARMOTA MONAX (WOODCHUCK).
MYCN_MOUSE N-MYC PROTO-ONCOGENE PROTEIN - MUS MUSCULUS (MOUSE).
MYCN_RAT N-MYC PROTO-ONCOGENE PROTEIN - RATTUS NORVEGICUS (RAT).
MYCN_SERCA N-MYC PROTO-ONCOGENE PROTEIN - SERINUS CANARIA (CANARY).
MYCN_XENLA N-MYC PROTO-ONCOGENE PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
MYCS_RAT S-MYC PROTO-ONCOGENE PROTEIN - RATTUS NORVEGICUS (RAT).
MYC_AVIM2 MYC TRANSFORMING PROTEIN - AVIAN MYELOCYTOMATOSIS VIRUS CMII.
MYC_AVIMC MYC TRANSFORMING PROTEIN - AVIAN MYELOCYTOMATOSIS VIRUS MC29.
MYC_AVIMD MYC TRANSFORMING PROTEIN - AVIAN MYELOCYTOMATOSIS VIRUS HBI.
MYC_AVIME MYC TRANSFORMING PROTEIN - AVIAN RETROVIRUS MH2E21.
MYC_AVIOK MYC TRANSFORMING PROTEIN - AVIAN RETROVIRUS OK10.
MYC_BRARE MYC PROTEIN (C-MYC) - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
MYC_CALJA MYC PROTO-ONCOGENE PROTEIN (C-MYC) - CALLITHRIX JACCHUS (COMMON MARMOSET).
MYC_CANFA MYC PROTO-ONCOGENE PROTEIN (C-MYC) - CANIS FAMILIARIS (DOG).
MYC_CARAU MYC PROTEIN (C-MYC) - CARASSIUS AURATUS (GOLDFISH).
MYC_CHICK MYC PROTO-ONCOGENE PROTEIN (C-MYC) - GALLUS GALLUS (CHICKEN).
MYC_FELCA MYC PROTO-ONCOGENE PROTEIN (C-MYC) - FELIS SILVESTRIS CATUS (CAT), AND FELINE LEUKEMIA VIRUS.
MYC_FLVTT MYC TRANSFORMING PROTEIN - FELINE LEUKEMIA PROVIRUS FTT.
MYC_HUMAN MYC PROTO-ONCOGENE PROTEIN (C-MYC) - HOMO SAPIENS (HUMAN).
MYC_HYLLA MYC PROTO-ONCOGENE PROTEIN (C-MYC) - HYLOBATES LAR (COMMON GIBBON).
MYC_MARMO MYC PROTO-ONCOGENE PROTEIN (C-MYC) - MARMOTA MONAX (WOODCHUCK).
MYC_MOUSE MYC PROTO-ONCOGENE PROTEIN (C-MYC) - MUS MUSCULUS (MOUSE).
MYC_PANTR MYC PROTO-ONCOGENE PROTEIN (C-MYC) - PAN TROGLODYTES (CHIMPANZEE).
MYC_PIG MYC PROTO-ONCOGENE PROTEIN (C-MYC) - SUS SCROFA (PIG).
MYC_RAT MYC PROTO-ONCOGENE PROTEIN (C-MYC) - RATTUS NORVEGICUS (RAT).
MYC_SHEEP MYC PROTO-ONCOGENE PROTEIN (C-MYC) - OVIS ARIES (SHEEP).
O43372 PAC CLONE DJ0320J15 FROM XQ23, COMPLETE SEQUENCE - HOMO SAPIENS (HUMAN).
O56221 P110 - AVIAN MYELOCYTOMATOSIS VIRUS.
Q85456 AVIAN PROVIRAL RETROVIRUS MYC PROTEIN - AVIAN CARCINOMA VIRUS.
Q85523 V-MYC GENE - FELINE LEUKEMIA VIRUS.
Q91421 MYC HOMOLOG - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI).
Q98927 AVIAN MYELOCYTOMATOSIS VIRUS MC29 (PROVIRAL), COMPLETE P96 POLYPROTEIN CODING SEQUENCE AND 5' LTR - GALLUS GALLUS (CHICKEN).

Q26649 MYC PROTEIN - STRONGYLOCENTROTUS PURPURATUS (PURPLE SEA URCHIN).
Q67004 MYC MUTANT (V-MYC) - FELINE LEUKEMIA VIRUS.

MAX_BRARE MAX PROTEIN - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
MAX_CHICK MAX PROTEIN - GALLUS GALLUS (CHICKEN).
MAX_HUMAN MAX PROTEIN - HOMO SAPIENS (HUMAN), AND FELIS SILVESTRIS CATUS (CAT).
MAX_MOUSE MAX PROTEIN (MYN PROTEIN) (MYC-BINDING NOVEL HLH/LZ PROTEIN) - MUS MUSCULUS (MOUSE).
MAX_RAT MAX PROTEIN - RATTUS NORVEGICUS (RAT).
MAX_XENLA MAX PROTEIN (XMAX) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
P91664 TRANSCRIPTION FACTOR DMAX - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q14803 MAX GENE - HOMO SAPIENS (HUMAN).
Q14897 L-MYC PROTEIN - HOMO SAPIENS (HUMAN).
Q14900 TRUNCATED C-MYC-P64 PROTEIN - HOMO SAPIENS (HUMAN).
Scan History
OWL19_1    2  100  NSINGLE    
OWL26_0 1 150 NSINGLE
SPTR37_9f 3 100 NSINGLE
Initial Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
PSEDIWKKFELLPTPPLSP MYC_PANTR 45 45 -
PSEDIWKKFELLPTPPLSP MYC_FELCA 45 45 -
PGEDIWKKFELLPTPPLSP MYCN_CHICK 37 37 -
PGEDIWKKFELLPTPPLSP MYCN_SERCA 37 37 -
PSEDIWKKFELVPSPPTSP MYCL_HUMAN 25 25 -
PGEDIWKKFELLPTPRLSP MYCS_RAT 45 45 -

Motif 2 width=16
Element Seqn Id St Int Rpt
IIIQDCMWSGFSAAAK MYC_PANTR 128 64 -
IIIQDCMWSGFSAAAK MYC_FELCA 128 64 -
IIIQDCMWSAFSAREK MYCN_CHICK 124 68 -
IIIQDCMWSGFSAREK MYCN_SERCA 122 66 -
IIRRDCMWSGFSARER MYCL_HUMAN 89 45 -
VVLQDCMWSGFSSREK MYCS_RAT 112 48 -

Motif 3 width=10
Element Seqn Id St Int Rpt
THQHNYAAPP MYC_PANTR 304 160 -
THQHNYAAPP MYC_FELCA 304 160 -
HQQHNYAAPS MYCN_CHICK 305 165 -
HQQHNYAAPS MYCN_SERCA 289 151 -
QQQHNYAARF MYCL_HUMAN 209 104 -
QEQHNYAAPP MYCS_RAT 292 164 -

Motif 4 width=17
Element Seqn Id St Int Rpt
SSDTEENDKRRTHNVLE MYC_PANTR 347 33 -
SSDTEENDKRRTHNVLE MYC_FELCA 347 33 -
NSDSEDSERRRNHNILE MYCN_CHICK 351 36 -
NSDSEDSERRRNHNILE MYCN_SERCA 335 36 -
SSDTEDVTKRKNHNFLE MYCL_HUMAN 274 55 -
NSDLEDIERRRNHNRME MYCS_RAT 339 37 -

Motif 5 width=16
Element Seqn Id St Int Rpt
RQRRNELKRSFFALRD MYC_PANTR 364 0 -
RQRRNELKRSFFALRD MYC_FELCA 364 0 -
RQRRNDLRSSFLTLRD MYCN_CHICK 368 0 -
RQRANDLRSSFLTLRD MYCN_SERCA 352 0 -
RKRRNDLRSRFLALRD MYCL_HUMAN 291 0 -
RQRRDIMRSSFLNLRD MYCS_RAT 356 0 -

Motif 6 width=14
Element Seqn Id St Int Rpt
KAPKVVILKKATAY MYC_PANTR 389 9 -
KAPKVVILKKATAY MYC_FELCA 389 9 -
KAAKVVILKKATEY MYCN_CHICK 393 9 -
KAAKVVILKKATEY MYCN_SERCA 378 10 -
KAPKVVILSKALEY MYCL_HUMAN 316 9 -
KAAKVVILKKATEY MYCS_RAT 381 9 -
Final Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
PSEDIWKKFELLPTPPLSP MYC_CHICK 48 48 -
PSEDIWKKFELLPTPPLSP MYC_AVIM2 53 53 -
PSEDIWKKFELLPTPPLSP MYC_CANFA 45 45 -
PSEDIWKKFELLPTPPLSP Q85523 45 45 -
PSEDIWKKFELLPTPPLSP MYC_SHEEP 45 45 -
PSEDIWKKFELLPTPPLSP MYC_RAT 45 45 -
PSEDIWKKFELLPTPPLSP MYC_PANTR 45 45 -
PSEDIWKKFELLPTPPLSP MYC_MOUSE 45 45 -
PSEDIWKKFELLPTPPLSP MYC_HYLLA 45 45 -
PSEDIWKKFELLPTPPLSP MYC_FELCA 45 45 -
PSEDIWKKFELLPTPPLSP MYC_CALJA 45 45 -
PSEDIWKKFELLPTPPLSP MYC_HUMAN 45 45 -
PSEDIWKKFELLPAPPLSP MYC_AVIOK 48 48 -
PSEDIWKKFELLPTPPLSP MYC_PIG 45 45 -
PSEDIWKKFELLPTPPLSP MYC_MARMO 45 45 -
PSEDIWKKFELLPTPPLSP MYC_FLVTT 45 45 -
PSEDIWKKFELLPMPPLSP Q98927 507 507 -
PSEDIWKKFELLPMPPLSP O56221 507 507 -
PSEDIWKKFELLPMPPLSP MYC_AVIMC 54 54 -
PSEDIWKKFELLPTPPLSP MYC2_XENLA 42 42 -
PSEDIWKKFELLPTPPLSP MYC1_CYPCA 45 45 -
PSEDIWKKFELLPTPPLSP MYC2_CYPCA 45 45 -
PSEDIWKKFELLPTPPLSP MYC_BRARE 45 45 -
PSEDIWKKFELLPTPPLSP MYC_CARAU 45 45 -
PSEDIWKKFELLPAPPLSP MYC_AVIME 59 59 -
PSEDIWKKFELLPAPPLSP Q85456 59 59 -
PSEDIWKKFELLPTPPLSP MYC1_XENLA 42 42 -
PSEDIWKKFELLPMPPLSP MYC_AVIMD 54 54 -
PGEDIWKKFELLPTPPLSP MYCN_XENLA 37 37 -
PGEDIWKKFELLPTPPLSP MYCN_CHICK 37 37 -
PGEDIWKKFELLPTPPLSP MYCN_SERCA 37 37 -
PGEDIWKKFELLPTPPLSP MYCN_RAT 45 45 -
PGEDIWKKFELLPTPPLSP MYCN_MOUSE 45 45 -
PGEDIWKKFELLPTPPLSP MYCN_MARMO 45 45 -
PGEDIWKKFELLPTPPLSP MYCN_HUMAN 45 45 -
PGEDIWKKFELLPTPPLSP MYC2_SPEBE 45 45 -
PGEDIWKKFELLPTPPLSP MYC2_MARMO 45 45 -
PSEDIWKKFELVPSPPTSP MYCL_MOUSE 25 25 -
PSEDIWKKFELVPSPPTSP MYCL_HUMAN 25 25 -
PGEDIWKKFELLPTPRLSP MYCS_RAT 45 45 -
PSEDISKKFELLSTPPLSP Q91421 43 43 -
PSEDIWKKFELVPGFPLSS MYCM_XENLA 26 26 -
PSEDIWKKFELVPGFPLSP MYCL_XENLA 26 26 -
PSEDIWKKFELVPPPWTWV MYCM_HUMAN 25 25 -
PSEDIWKKFELVPPPWDLG O43372 25 25 -

Motif 2 width=16
Element Seqn Id St Int Rpt
IIIQDCMWSGFSAAAK MYC_CHICK 114 47 -
IIIQDCMWSGFSAAAK MYC_AVIM2 119 47 -
IIIQDCMWSGFSAAAK MYC_CANFA 128 64 -
IIIQDCMWSGFSAAAK Q85523 128 64 -
IIIQDCMWSGFSAAAK MYC_SHEEP 128 64 -
IIIQDCMWSGFSAAAK MYC_RAT 129 65 -
IIIQDCMWSGFSAAAK MYC_PANTR 128 64 -
IIIQDCMWSGFSAAAK MYC_MOUSE 129 65 -
IIIQDCMWSGFSAAAK MYC_HYLLA 128 64 -
IIIQDCMWSGFSAAAK MYC_FELCA 128 64 -
IIIQDCMWSGFSAAAK MYC_CALJA 128 64 -
IIIQDCMWSGFSAAAK MYC_HUMAN 128 64 -
IIIQDCMWSGFSAAAK MYC_AVIOK 114 47 -
IIIQDCMWSGFSAAAK MYC_PIG 128 64 -
IIIQDCMWSGFSAAAK MYC_MARMO 128 64 -
IIIQDCMWSGFSAAAK MYC_FLVTT 128 64 -
IIIQDCMWSGFSAAAK Q98927 573 47 -
IIIQDCMWSGFSAAAK O56221 573 47 -
IIIQDCMWSGFSAAAK MYC_AVIMC 120 47 -
IVIQDCMWSGFSAAAK MYC2_XENLA 106 45 -
IIIQDCMWSGFSAAAK MYC1_CYPCA 105 41 -
IIIQDCMWSGFSAAAK MYC2_CYPCA 105 41 -
IIIQDCMWSGFSAAAK MYC_BRARE 106 42 -
IIIQDCMWSGFSAAAK MYC_CARAU 105 41 -
IIIRDCMWSGFSAAAK MYC_AVIME 125 47 -
IIIRDCMWSGFSAAAK Q85456 125 47 -
IVIQDCMWSGFSAAAK MYC1_XENLA 106 45 -
IIIQDCMWSGFSAAAK MYC_AVIMD 120 47 -
IIIQDCMWSGFSAREK MYCN_XENLA 111 55 -
IIIQDCMWSAFSAREK MYCN_CHICK 124 68 -
IIIQDCMWSGFSAREK MYCN_SERCA 122 66 -
VILQDCMWSGFSAREK MYCN_RAT 111 47 -
VILQDCMWSGFSAREK MYCN_MOUSE 111 47 -
VILQDCMWSGFSAREK MYCN_MARMO 111 47 -
VILQDCMWSGFSAREK MYCN_HUMAN 110 46 -
VILRDCMWSGFSAREK MYC2_SPEBE 111 47 -
VILRDCMWSGFSAREK MYC2_MARMO 111 47 -
IIRRDCMWSGFSARER MYCL_MOUSE 89 45 -
IIRRDCMWSGFSARER MYCL_HUMAN 89 45 -
VVLQDCMWSGFSSREK MYCS_RAT 112 48 -
IIIQDCMWSGFSAAAK Q91421 108 46 -
VLLRDCMWSGFSTRER MYCM_XENLA 77 32 -
VLLRDCMWSGFSTRER MYCL_XENLA 77 32 -
LIRRDCMWSGFSTQEP MYCM_HUMAN 83 39 -
LIRRDCMWSGFSTQEP O43372 84 40 -

Motif 3 width=10
Element Seqn Id St Int Rpt
IHQHNYAAPP MYC_CHICK 281 151 -
IHQHNYAAPP MYC_AVIM2 286 151 -
THQHNYAAPP MYC_CANFA 304 160 -
THQHNYAAPP Q85523 306 162 -
THQHNYAAPP MYC_SHEEP 304 160 -
THQHNYAAPP MYC_RAT 304 159 -
THQHNYAAPP MYC_PANTR 304 160 -
THQHNYAAPP MYC_MOUSE 304 159 -
THQHNYAAPP MYC_HYLLA 304 160 -
THQHNYAAPP MYC_FELCA 304 160 -
THQHNYAAPP MYC_CALJA 303 159 -
THQHNYAAPP MYC_HUMAN 304 160 -
IHQHNYAAPP MYC_AVIOK 281 151 -
THQHNYAAPP MYC_PIG 304 160 -
THQHNYAAPP MYC_MARMO 304 160 -
THQHNYAAPP MYC_FLVTT 304 160 -
IHQHNYAAPP Q98927 740 151 -
IHQHNYAAPP O56221 740 151 -
IHQHNYAAPP MYC_AVIMC 287 151 -
IHQHNYAASP MYC2_XENLA 285 163 -
THQHNYAAHP MYC1_CYPCA 259 138 -
THQHNYAAHP MYC2_CYPCA 263 142 -
THQHNYAAHP MYC_BRARE 264 142 -
THQHNYAAHP MYC_CARAU 266 145 -
IHQHNYAAPP MYC_AVIME 288 147 -
IHQHNYAAPP Q85456 288 147 -
IHQHNYAASP MYC1_XENLA 284 162 -
IHQHNYAAPP MYC_AVIMD 287 151 -
HQQHNYAAPS MYCN_XENLA 300 173 -
HQQHNYAAPS MYCN_CHICK 305 165 -
HQQHNYAAPS MYCN_SERCA 289 151 -
HQQHNYAAPS MYCN_RAT 325 198 -
HQQHNYAAPS MYCN_MOUSE 325 198 -
HQQHNYAAPS MYCN_MARMO 323 196 -
HQQHNYAAPS MYCN_HUMAN 327 201 -
YQQHNYAAPS MYC2_SPEBE 317 190 -
YQQHNYAAPS MYC2_MARMO 317 190 -
QQQHNYAARF MYCL_MOUSE 209 104 -
QQQHNYAARF MYCL_HUMAN 209 104 -
QEQHNYAAPP MYCS_RAT 292 164 -
THQHNYAAHP Q91421 254 130 -
QQQHNYAARL MYCM_XENLA 199 106 -
QQQHNYAARL MYCL_XENLA 199 106 -
QQQHNYAAPF MYCM_HUMAN 202 103 -
QQQHNYAAPF O43372 203 103 -

Motif 4 width=17
Element Seqn Id St Int Rpt
TSDSEENDKRRTHNVLE MYC_CHICK 324 33 -
TSDSEENDKRRTHNVLE MYC_AVIM2 329 33 -
SSDTEENDKRRTHNVLE MYC_CANFA 347 33 -
SSDTEENDKRRTHNVLE Q85523 349 33 -
SSDTEENDKRRTHNVLE MYC_SHEEP 347 33 -
SSDTEENDKRRTHNVLE MYC_RAT 347 33 -
SSDTEENDKRRTHNVLE MYC_PANTR 347 33 -
SSDTEENDKRRTHNVLE MYC_MOUSE 347 33 -
SSDTEENDKRRTHNVLE MYC_HYLLA 347 33 -
SSDTEENDKRRTHNVLE MYC_FELCA 347 33 -
SSDTEENDKRRTHNVLE MYC_CALJA 346 33 -
SSDTEENVKRRTHNVLE MYC_HUMAN 347 33 -
TSDSEENDKRRMHNVLE MYC_AVIOK 324 33 -
SSDTEENDKRRTHNVLE MYC_PIG 347 33 -
SSDTEENDKRRTHNVLE MYC_MARMO 347 33 -
SSDTEENDKRRTDNVLE MYC_FLVTT 347 33 -
TLDSEENDKRRTHNVLE Q98927 783 33 -
TLDSEENDKRRTHNVLE O56221 783 33 -
TLDSEENDKRRTHNVLE MYC_AVIMC 330 33 -
SSDSEENDKRRTHNVLE MYC2_XENLA 329 34 -
TSDSEDNDKRRTHNVLE MYC1_CYPCA 303 34 -
TSDSEDNDKRRTHNVLE MYC2_CYPCA 310 37 -
TSDSEDNDKRRTHNVLE MYC_BRARE 315 41 -
TSDSEDNDKRRTHNVLE MYC_CARAU 308 32 -
TSDSEVNDKRRTHNVLE MYC_AVIME 331 33 -
TSDSEVNDKRRTHNVLE Q85456 331 33 -
SSDSEENDKRKTHNVLE MYC1_XENLA 328 34 -
TLDSEENDKRRTHNVLE MYC_AVIMD 330 33 -
NYDSEDSERRRNHNILE MYCN_XENLA 347 37 -
NSDSEDSERRRNHNILE MYCN_CHICK 351 36 -
NSDSEDSERRRNHNILE MYCN_SERCA 335 36 -
NSDSEDSERRRNHNILE MYCN_RAT 372 37 -
NSDSEDSERRRNHNILE MYCN_MOUSE 372 37 -
NSDSEDSERRRNHNILE MYCN_MARMO 370 37 -
NSDSEDSERRRNHNILE MYCN_HUMAN 374 37 -
KSDSEDSVRRRNHNILE MYC2_SPEBE 364 37 -
KSDSEDSVRRRNHNILE MYC2_MARMO 364 37 -
SSDTEDVTKRKNHNFLE MYCL_MOUSE 278 59 -
SSDTEDVTKRKNHNFLE MYCL_HUMAN 274 55 -
NSDLEDIERRRNHNRME MYCS_RAT 339 37 -
RQITEDYVKRRTHYVLE Q91421 303 39 -
SSDSEDLAKRKNHNYLE MYCM_XENLA 254 45 -
SSDSEDIVKKKNHNYLE MYCL_XENLA 254 45 -
HYDTENWTKKKYHSYLE MYCM_HUMAN 267 55 -
HYDTENWTKKKYHSYLE O43372 268 55 -

Motif 5 width=16
Element Seqn Id St Int Rpt
RQRRNELKLSFFALRD MYC_CHICK 341 0 -
RQRRNELKLSFFALRD MYC_AVIM2 346 0 -
RQRRNELKRSFFALRD MYC_CANFA 364 0 -
RQRRNELKRSFFALRD Q85523 366 0 -
RQRRNELKRSFFALRD MYC_SHEEP 364 0 -
RQRRNELKRSFFALRD MYC_RAT 364 0 -
RQRRNELKRSFFALRD MYC_PANTR 364 0 -
RQRRNELKRSFFALRD MYC_MOUSE 364 0 -
RQRRNELKRSFFALRD MYC_HYLLA 364 0 -
RQRRNELKRSFFALRD MYC_FELCA 364 0 -
RQRRNELKRSFFALRD MYC_CALJA 363 0 -
RQRRNELKRSFFALRD MYC_HUMAN 364 0 -
RQRRNELKLSFFALRD MYC_AVIOK 341 0 -
RQRRNELKRSFFARRD MYC_PIG 364 0 -
RQRRNELKRSFFALRD MYC_MARMO 364 0 -
RQRRNELKRSFFALRD MYC_FLVTT 364 0 -
RQRRNELKLRFFALRD Q98927 800 0 -
RQRRNELKLRFFALRD O56221 800 0 -
RQRRNELKLRFFALRD MYC_AVIMC 347 0 -
RQRRNELKLSFFALRD MYC2_XENLA 346 0 -
RQRRNELKLSFFALRD MYC1_CYPCA 320 0 -
RQRRNELKLSFFALRD MYC2_CYPCA 327 0 -
RQRRNELKLSFFALRD MYC_BRARE 332 0 -
RQRRNELKLSFFALRD MYC_CARAU 325 0 -
RQRRNELKLSFFALRD MYC_AVIME 348 0 -
RQRRNELKLSFFALRD Q85456 348 0 -
RQRRNELKLSFFALRD MYC1_XENLA 345 0 -
RQRRNELKLRFFALRD MYC_AVIMD 347 0 -
RQRRNDLRSSFLTLRD MYCN_XENLA 364 0 -
RQRRNDLRSSFLTLRD MYCN_CHICK 368 0 -
RQRANDLRSSFLTLRD MYCN_SERCA 352 0 -
RQRRNDLRSSFLTLRD MYCN_RAT 389 0 -
RQRRNDLRSSFLTLRD MYCN_MOUSE 389 0 -
RQRRNDLRSSFLTLRD MYCN_MARMO 387 0 -
RQRRNDLRSSFLTLRD MYCN_HUMAN 391 0 -
RQRRNDLRSSFTTLRD MYC2_SPEBE 381 0 -
RQRRNDLRSSFTTLRD MYC2_MARMO 381 0 -
RKRRNDLRSRFLALRD MYCL_MOUSE 295 0 -
RKRRNDLRSRFLALRD MYCL_HUMAN 291 0 -
RQRRDIMRSSFLNLRD MYCS_RAT 356 0 -
RQRRSEVKLNFFLSLR Q91421 320 0 -
RKRRNDLRSRFLALRE MYCM_XENLA 271 0 -
RKRRNDLRSRFLALRE MYCL_XENLA 271 0 -
RKRRNDQRSRFLALRD MYCM_HUMAN 284 0 -
RKRRNDQRSRFLALRD O43372 285 0 -

Motif 6 width=14
Element Seqn Id St Int Rpt
KAPKVVILKKATEY MYC_CHICK 366 9 -
KAPKVVILKKATEY MYC_AVIM2 371 9 -
KAPKVVILKKATAY MYC_CANFA 389 9 -
KAPKVVILKKATAY Q85523 391 9 -
KAPKVVILKKATAY MYC_SHEEP 389 9 -
KAPKVVILKKATAY MYC_RAT 389 9 -
KAPKVVILKKATAY MYC_PANTR 389 9 -
KAPKVVILKKATAY MYC_MOUSE 389 9 -
KAPKVVILKKATAY MYC_HYLLA 389 9 -
KAPKVVILKKATAY MYC_FELCA 389 9 -
KAPKVVILKKATTY MYC_CALJA 388 9 -
KAPKVVILKKATAY MYC_HUMAN 389 9 -
KAPKVVILKKATEY MYC_AVIOK 366 9 -
KAPKVVILKKATAY MYC_PIG 389 9 -
KAPKVIILKKATAY MYC_MARMO 389 9 -
KAPKVVILKKATAY MYC_FLVTT 389 9 -
KAPKVVILKKATEY Q98927 825 9 -
KAPKVVILKKATEY O56221 825 9 -
KAPKVVILKKATEY MYC_AVIMC 372 9 -
KAPKVVILKKATEY MYC2_XENLA 371 9 -
KAAKVVILKKATEC MYC1_CYPCA 345 9 -
KAAKVVILKKATEC MYC2_CYPCA 352 9 -
KAAKVVILKKATEC MYC_BRARE 357 9 -
KAAKVVILKKATEC MYC_CARAU 350 9 -
KAPKVVILKRATEY MYC_AVIME 373 9 -
KAPKVVILKRATEY Q85456 373 9 -
KAPKVVILKKATEY MYC1_XENLA 370 9 -
KAPKVGILKKATEY MYC_AVIMD 372 9 -
KAAKVVILKKATEY MYCN_XENLA 389 9 -
KAAKVVILKKATEY MYCN_CHICK 393 9 -
KAAKVVILKKATEY MYCN_SERCA 378 10 -
KAAKVVILKKATEY MYCN_RAT 414 9 -
KAAKVVILKKATEY MYCN_MOUSE 414 9 -
KAAKVVILKKATEY MYCN_MARMO 412 9 -
KAAKVVILKKATEY MYCN_HUMAN 416 9 -
KAAKVVILKKACEY MYC2_SPEBE 406 9 -
KAAKVVILKKACEY MYC2_MARMO 406 9 -
KAPKVVILSKALEY MYCL_MOUSE 320 9 -
KAPKVVILSKALEY MYCL_HUMAN 316 9 -
KAAKVVILKKATEY MYCS_RAT 381 9 -
KASKVVILEKAIEC Q91421 346 10 -
KTPKVVVLSKATEF MYCM_XENLA 296 9 -
KTPKVVVLSKATEF MYCL_XENLA 296 9 -
RVSKVMILVKATEY MYCM_HUMAN 309 9 -
RVSKVMILVKATEY O43372 310 9 -