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PR01680

Identifier
TNFACTORR6  [View Relations]  [View Alignment]  
Accession
PR01680
No. of Motifs
5
Creation Date
31-JAN-2002  (UPDATE 29-AUG-2008)
Title
Tumour necrosis factor receptor 6 signature
Database References

PDB; 1DDF; 1BZI
SCOP; 1DDF; 1BZI
CATH; 1DDF; 1BZI
Literature References
1. GOLDSBY, R.A., KINDT, T.J. AND OSBORNE, B.A.
Kuby immunology.
W.H.FREEMAN AND COMPANY, 2000, pp.260-261, 503-504.
 
2. WENZEL, J., SANZENBACHER, R., GHADIMI, M., ZHOU, Q., KAPLAN, D.R.,
KABELITZ, D., FELLER, S.M. AND JANSSEN, O.
Multiple interactions of the cytosolic polyproline region of the CD95 ligand: 
hints for the reverse signal tranduction capacity of a death factor.
FEBS LETT. 509 255-262 (2001).
 
3. YANKEE, T.M., DRAVES, K.E., EWINGS, M.K., CLARK, E.A. AND GRAVES, J.D.
CD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of 
antigen receptor signaling.
PROC.NATL.ACAD.SCI.U.S.A. 98 6789-6793 (2001).

Documentation
Like all apoptotic cell death, T cell receptor (TCR)-mediated death can be
divided into two phases: an inductive phase and an effector phase. The 
effector phase includes a sequence of steps that are common to apoptosis in
many cell types, which, if not interrupted, will lead to cell death. The
induction phase, which often requires the expression of new genes, consists
of a set of signals that activate the effector phase. Outside the thymus,
most, if not all, of the TCR-mediated apoptosis of mature T cells (sometimes
referred to as activation-induced cell death (AICD)) is induced through the
surface antigen Fas pathway: activation through the TCR induces expression
of the Fas (CD95) ligand (FasL); the expression of FasL on either a
neighbouring cell, or on the Fas-bearing cell, induces trimerisation of Fas,
which then initiates a signal-transduction cascade, leading to apoptosis of 
the Fas-bearing cell. This commitment stage requires the activation of key
death-inducing enzymes, termed caspases, which act by cleaving proteins that
are essential for cell survival and proliferation [1,2].
 
Fas is also known to be essential in the death of hyperactivated peripheral
CD4+ cells: in the absence of Fas, mature peripheral T cells do not die, but
the activated cells continue to proliferate, producing cytokines that lead
to grossly enlarged lymph nodes and spleen. Fas belongs to the tumour
necrosis factor receptor (TNFR) family of cysteine-rich type I membrane
receptors; its ligand (FasL) is expressed on activated lymphocytes, NK cells,
platelets, certain immune-privileged cells and some tumour cells [1,3].
 
Defects in the Fas-FasL system are associated with various disease syndromes.
Mice with non-functional Fas or FasL display characteristics of lympho-
proliferative disorder, such as lymphadenopathy, splenomegaly, and elevated 
secretion of IgM and IgG. These mice also secrete anti-DNA autoantibodies
and rheumatoid factor [3].
 
TNFACTORR6 (formerly FASRECEPTOR) is a 5-element fingerprint that provides
a signature for tumour necrosis factor 6 (FAS/CD95 receptor family). The
fingerprint was derived from an initial alignment of 6 sequences: the motifs
were drawn from conserved regions spanning virtually the full alignment
length - motif 3 spans alpha-helix 1 and beta-strand 1; and motif 4 
encompasses strand 2. Two iterations on SPTR39_17f were required to reach
convergence, at which point a true set comprising 18 sequences was
identified. Three partial matches were also found: Q9XS60 is a Fas antigen
263-residue splice variant that lacks motif 5; and Q14292 and Q16652 are
Fas soluble proteins that lack the region of sequence bearing motifs 4 and 5.
 
An update on SPTR55_38f identified a true set comprising 24 sequences,
together with 3 partial matches.
Summary Information
  24 codes involving  5 elements
3 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
52424242424
432331
300000
200000
12345
True Positives
A1Y9B2_MOUSE  A5D7R0_BOVIN  A8WA68_CALJA  A8WEX9_CALJA  
A9UJX4_HUMAN FASA_BOVIN FASA_HUMAN FASA_MOUSE
FASA_PIG FASA_RAT O97491 Q5T9P1_HUMAN
Q5T9P2_HUMAN Q6GT31_MOUSE Q9BDN0 Q9BDN4
Q9BDP0 Q9BDP2 Q9GK28 Q9GK36
Q9GL40 Q9TSN4 Q9TV79 Q9XS29
True Positive Partials
Codes involving 4 elements
Q5T9P3_HUMAN Q861W6_FELCA Q9XS60
Sequence Titles
A1Y9B2_MOUSE Fas - Mus musculus (Mouse).                   
A5D7R0_BOVIN TNFRSF6 protein - Bos taurus (Bovine).
A8WA68_CALJA FAS antigen CD95 - Callithrix jacchus (Common marmoset).
A8WEX9_CALJA FAS antigen CD95 - Callithrix jacchus (Common marmoset).
A9UJX4_HUMAN Fas AMA - Homo sapiens (Human).
FASA_BOVIN FASL RECEPTOR PRECURSOR (APOPTOSIS-MEDIATING SURFACE ANTIGEN FAS) (APO-1 ANTIGEN) (CD95) - Bos taurus (Bovine).
FASA_HUMAN FASL RECEPTOR PRECURSOR (APOPTOSIS-MEDIATING SURFACE ANTIGEN FAS) (APO-1 ANTIGEN) (CD95 ANTIGEN) - Homo sapiens (Human).
FASA_MOUSE FASL RECEPTOR PRECURSOR (APOPTOSIS-MEDIATING SURFACE ANTIGEN FAS) (APO-1 ANTIGEN) (CD95) - Mus musculus (Mouse).
FASA_PIG FASL RECEPTOR PRECURSOR (APOPTOSIS-MEDIATING SURFACE ANTIGEN FAS) (APO-1 ANTIGEN) (CD95) - Sus scrofa (Pig).
FASA_RAT FASL RECEPTOR PRECURSOR (APOPTOSIS-MEDIATING SURFACE ANTIGEN FAS) (APO-1 ANTIGEN) (CD95) - Rattus norvegicus (Rat).
O97491 FAS PROTEIN - Ovis aries (Sheep).
Q5T9P1_HUMAN Fas (TNF receptor superfamily, member 6) (Fas (TNF receptor superfamily, member 6), isoform CRA_e) (cDNA FLJ77106, highly similar to Homo sapiens Fas (TNF receptor superfamily, member 6) (FAS), transcript variant 1, mRNA) - Homo sapiens (Human).
Q5T9P2_HUMAN Fas (TNF receptor superfamily, member 6) - Homo sapiens (Human).
Q6GT31_MOUSE Fas (TNF receptor superfamily member 6) - Mus musculus (Mouse).
Q9BDN0 FAS ANTIGEN CD95 - Macaca nemestrina (Pig-tailed macaque).
Q9BDN4 FAS ANTIGEN CD95 - Cercocebus torquatus atys (Red-crowned mangabey) (Sooty mangabey).
Q9BDP0 FAS ANTIGEN CD95 - Aotus trivirgatus (Night monkey) (Douroucouli).
Q9BDP2 FAS ANTIGEN CD95 - Macaca mulatta (Rhesus macaque).
Q9GK28 FAS ANTIGEN APO-1/CD95 - Macaca arctoides (Stump-tailed macaque).
Q9GK36 FAS ANTIGEN APO-1/CD95 - Macaca assamensis (Assam's macaque) (Assam's monkey).
Q9GL40 FAS ANTIGEN - Macaca mulatta (Rhesus macaque).
Q9TSN4 DEATH RECEPTOR FAS (APO-1/CD95) - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
Q9TV79 B-TYPE FAS ANTIGEN - Oryctolagus cuniculus (Rabbit).
Q9XS29 C-TYPE FAS ANTIGEN - Oryctolagus cuniculus (Rabbit).

Q5T9P3_HUMAN Fas (TNF receptor superfamily, member 6) - Homo sapiens (Human).
Q861W6_FELCA Fas antigen - Felis silvestris catus (Cat).
Q9XS60 FAS ANTIGEN SPLICED VARIANT - Oryctolagus cuniculus (Rabbit).
Scan History
SPTR39_17f 2  100  NSINGLE    
SPTR55_38f 1 100 NSINGLE
Initial Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
PCPPGERKARDCTVN Q9BDN0 62 62 -
PCPPGERKARDCTVN Q9BDP2 62 62 -
PCPPGERKARDCTVN Q9TSN4 62 62 -
PCPPGERKARDCTVN Q9BDN4 62 62 -
PCPPGERKARDCTVN FASA_HUMAN 62 62 -
PCPPGKRKNGDCKRD FASA_BOVIN 59 59 -
PCPPGKRKHADCTSP FASA_PIG 60 60 -
PCQPGKKKVEDCKMN FASA_MOUSE 58 58 -
PCQPGERKVKDCTTS FASA_RAT 58 58 -

Motif 2 width=11
Element Seqn Id St Int Rpt
DEPDCVPCQEG Q9BDN0 78 1 -
DEPDCVPCQEG Q9BDP2 78 1 -
DEPDCVPCQEG Q9TSN4 78 1 -
DEPDCVPCQEG Q9BDN4 78 1 -
DEPDCVPCQEG FASA_HUMAN 78 1 -
DTPECVLCSEG FASA_BOVIN 75 1 -
GAPQCVPCSEG FASA_PIG 76 1 -
GTPTCAPCTEG FASA_MOUSE 74 1 -
GAPTCHPCTEG FASA_RAT 74 1 -

Motif 3 width=17
Element Seqn Id St Int Rpt
KCRRCRLCDEGHGLEVE Q9BDN0 100 11 -
KCRRCRLCDEGHGLEVE Q9BDP2 100 11 -
KCRRCRLCDEGHGLEVE Q9TSN4 100 11 -
KCRRCRLCDEGHGLEVE Q9BDN4 100 11 -
KCRRCRLCDEGHGLEVE FASA_HUMAN 100 11 -
KCIRCSICDEEHGLEVE FASA_BOVIN 97 11 -
KCRRCRVCDGEHGLEVE FASA_PIG 98 11 -
KCRRCTLCDEEHGLEVE FASA_MOUSE 96 11 -
KCRRCAFCDEGHGLEVE FASA_RAT 96 11 -

Motif 4 width=28
Element Seqn Id St Int Rpt
NCTRTQNTKCRCKPNFFCNSAVCEHCDP Q9BDN0 118 1 -
NCTRTQNTKCRCKPNFFCNSAVCEHCDP Q9BDP2 118 1 -
NCTRTQNTKCRCKPNFFCNSAVCEHCDP Q9TSN4 118 1 -
NCTRTQNTKCRCKPNFFCNSAVCEHCDP Q9BDN4 118 1 -
NCTRTQNTKCRCKPNFFCNSTVCEHCDP FASA_HUMAN 118 1 -
NCTRTRNTKCRCKSNFFCNSSPCEHCNP FASA_BOVIN 115 1 -
NCTRTQNTKCRCKPNFFCHTSQCEHCNP FASA_PIG 116 1 -
NCTLTQNTKCKCKPDFYCDSPGCEHCVR FASA_MOUSE 114 1 -
NCTRTQNTKCRCKENFYCNASLCDHCYH FASA_RAT 114 1 -

Motif 5 width=16
Element Seqn Id St Int Rpt
NLSDVDLSKYITTIAG Q9BDN0 219 73 -
NLSDVDLSKYITTIAG Q9BDP2 221 75 -
NLSDVDLSKYITTIAG Q9TSN4 219 73 -
NLSDVDLSKYITTIAG Q9BDN4 219 73 -
NLSDVDLSKYITTIAG FASA_HUMAN 223 77 -
NLTDVDLGKYIPSIAE FASA_BOVIN 215 72 -
MIKDVDLGKYITRIAE FASA_PIG 220 76 -
NASNLSLSKYIPRIAE FASA_MOUSE 215 73 -
NVSDVNLNKYIWRTAE FASA_RAT 212 70 -
Final Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
PCPPGERKARDCTVN Q9GK28 62 62 -
PCPPGERKARDCTVN Q9BDN0 62 62 -
PCPPGERKARDCTVN Q9BDP2 62 62 -
PCPPGERKARDCTVN Q9TSN4 62 62 -
PCPPGERKARDCTVN Q9BDN4 62 62 -
PCPPGERKARDCTVN Q9GK36 62 62 -
PCPPGERKARDCTVN A9UJX4_HUMAN 62 62 -
PCPPGERKARDCTVN FASA_HUMAN 62 62 -
PCPPGERKARDCTVN Q5T9P2_HUMAN 62 62 -
PCPPGERKARDCTVN Q5T9P1_HUMAN 62 62 -
PCPPGERKARDCTVN Q9GL40 62 62 -
PCSPGEKKARDCTVD Q9BDP0 61 61 -
PCGPGEKKARECTVD A8WEX9_CALJA 61 61 -
PCGPGEKKARECTVD A8WA68_CALJA 61 61 -
PCPPGKRKNGDCKRD O97491 61 61 -
LCPPGTKKKADCTSN Q9TV79 47 47 -
LCPPGTKKKADCTSN Q9XS29 47 47 -
PCPPGKRKNGDCKRD A5D7R0_BOVIN 59 59 -
PCPPGKRKNGDCKRD FASA_BOVIN 59 59 -
PCPPGKRKHADCTSP FASA_PIG 60 60 -
PCQPGKKKVEDCKMN Q6GT31_MOUSE 58 58 -
PCQPGKKKVEDCKMN FASA_MOUSE 58 58 -
PCQPGERKVKDCTTS FASA_RAT 58 58 -
LCSPGEKKVEDCKTN A1Y9B2_MOUSE 58 58 -

Motif 2 width=11
Element Seqn Id St Int Rpt
DEPDCVPCQEG Q9GK28 78 1 -
DEPDCVPCQEG Q9BDN0 78 1 -
DEPDCVPCQEG Q9BDP2 78 1 -
DEPDCVPCQEG Q9TSN4 78 1 -
DEPDCVPCQEG Q9BDN4 78 1 -
DEPDCVPCQEG Q9GK36 78 1 -
DEPDCVPCQEG A9UJX4_HUMAN 78 1 -
DEPDCVPCQEG FASA_HUMAN 78 1 -
DEPDCVPCQEG Q5T9P2_HUMAN 78 1 -
DEPDCVPCQEG Q5T9P1_HUMAN 78 1 -
DEPDCVPCQEG Q9GL40 78 1 -
DEPDCVPCQEG Q9BDP0 77 1 -
DEPDCVPCQEG A8WEX9_CALJA 77 1 -
DEPDCVPYQEG A8WA68_CALJA 77 1 -
DMPECVLCSEG O97491 77 1 -
GKPDCEPCQEG Q9TV79 63 1 -
GKPDCEPCQEG Q9XS29 63 1 -
DTPECVLCSEG A5D7R0_BOVIN 75 1 -
DTPECVLCSEG FASA_BOVIN 75 1 -
GAPQCVPCSEG FASA_PIG 76 1 -
GTPTCAPCTEG Q6GT31_MOUSE 74 1 -
GTPTCAPCTEG FASA_MOUSE 74 1 -
GAPTCHPCTEG FASA_RAT 74 1 -
GKPICTSCTEG A1Y9B2_MOUSE 74 1 -

Motif 3 width=17
Element Seqn Id St Int Rpt
KCRRCRLCDEGHGLEVE Q9GK28 100 11 -
KCRRCRLCDEGHGLEVE Q9BDN0 100 11 -
KCRRCRLCDEGHGLEVE Q9BDP2 100 11 -
KCRRCRLCDEGHGLEVE Q9TSN4 100 11 -
KCRRCRLCDEGHGLEVE Q9BDN4 100 11 -
KCRRCRLCDEGHGLEVE Q9GK36 100 11 -
KCRRCRLCDEGHGLEVE A9UJX4_HUMAN 100 11 -
KCRRCRLCDEGHGLEVE FASA_HUMAN 100 11 -
KCRRCRLCDEGHGLEVE Q5T9P2_HUMAN 100 11 -
KCRRCRLCDEGHGLEVE Q5T9P1_HUMAN 100 11 -
KCRRCRLCDEGHGLEVE Q9GL40 100 11 -
KCRRCRLCDEGHGLEVE Q9BDP0 99 11 -
KCRRCRLCDEGRGLEVE A8WEX9_CALJA 99 11 -
KCRRCRLCDEGHGLEVE A8WA68_CALJA 99 11 -
KCIRCSVCDEEHGLEVE O97491 99 11 -
KCRRCSLCDGEHGLEVE Q9TV79 85 11 -
KCRRCSLCDGEHGLEVE Q9XS29 85 11 -
KCIRCSICDEEHGLEVE A5D7R0_BOVIN 97 11 -
KCIRCSICDEEHGLEVE FASA_BOVIN 97 11 -
KCRRCRVCDGEHGLEVE FASA_PIG 98 11 -
KCRRCTLCDEEHGLEVE Q6GT31_MOUSE 96 11 -
KCRRCTLCDEEHGLEVE FASA_MOUSE 96 11 -
KCRRCAFCDEGHGLEVE FASA_RAT 96 11 -
KCRRCTLCDEEHGLEVE A1Y9B2_MOUSE 96 11 -

Motif 4 width=28
Element Seqn Id St Int Rpt
NCTRTQNTKCRCKPNFFCNSAVCEHCDP Q9GK28 118 1 -
NCTRTQNTKCRCKPNFFCNSAVCEHCDP Q9BDN0 118 1 -
NCTRTQNTKCRCKPNFFCNSAVCEHCDP Q9BDP2 118 1 -
NCTRTQNTKCRCKPNFFCNSAVCEHCDP Q9TSN4 118 1 -
NCTRTQNTKCRCKPNFFCNSAVCEHCDP Q9BDN4 118 1 -
NCTRTQNTKCRCKPNFFCNSAVCEHCDP Q9GK36 118 1 -
NCTRTQNTKCRCKPNFFCNSTVCEHCDP A9UJX4_HUMAN 118 1 -
NCTRTQNTKCRCKPNFFCNSTVCEHCDP FASA_HUMAN 118 1 -
NCTRTQNTKCRCKPNFFCNSTVCEHCDP Q5T9P2_HUMAN 118 1 -
NCTRTQNTKCRCKPNFFCNSTVCEHCDP Q5T9P1_HUMAN 118 1 -
NCTRTQNTRCRCKPNFFCNSAVCEHCDP Q9GL40 118 1 -
NCTRTQNTKCRCKPNFFCNSAVCEHCDP Q9BDP0 117 1 -
NCTRTQNTKCRCKPNFFCNSAVCEHCDP A8WEX9_CALJA 117 1 -
NCTRTQNTKCRCKPNFFCNSAVCEHCDP A8WA68_CALJA 117 1 -
NCTRTQNTKCRCKSNFFCNSSPCEHCNP O97491 117 1 -
DCTTIQNTKCRCKSNFFCNALKCEHCDP Q9TV79 103 1 -
DCTTIQNTKCRCKSNFFCNALKCEHCDP Q9XS29 103 1 -
NCTRTRNTKCRCKSNFFCNSSPCEHCNP A5D7R0_BOVIN 115 1 -
NCTRTRNTKCRCKSNFFCNSSPCEHCNP FASA_BOVIN 115 1 -
NCTRTQNTKCRCKPNFFCHTSQCEHCNP FASA_PIG 116 1 -
NCTLTQNTKCKCKPDFYCDSPGCEHCVR Q6GT31_MOUSE 114 1 -
NCTLTQNTKCKCKPDFYCDSPGCEHCVR FASA_MOUSE 114 1 -
NCTRTQNTKCRCKENFYCNASLCDHCYH FASA_RAT 114 1 -
NCTPTQNTKCKCKPDFYCDSSGCEHCVR A1Y9B2_MOUSE 114 1 -

Motif 5 width=16
Element Seqn Id St Int Rpt
NLSDVDLSKYITTIAG Q9GK28 198 52 -
NLSDVDLSKYITTIAG Q9BDN0 219 73 -
NLSDVDLSKYITTIAG Q9BDP2 221 75 -
NLSDVDLSKYITTIAG Q9TSN4 219 73 -
NLSDVDLSKYITTIAG Q9BDN4 219 73 -
NLSDVDLSKYITTIAG Q9GK36 219 73 -
NLSDVDLSKYITTIAG A9UJX4_HUMAN 223 77 -
NLSDVDLSKYITTIAG FASA_HUMAN 223 77 -
NLSDVDLSKYITTIAG Q5T9P2_HUMAN 202 56 -
NLSDVDLSKYITTIAG Q5T9P1_HUMAN 223 77 -
NLSDVDLSKYITTIAG Q9GL40 222 76 -
NLSDVDLSKYITVIAE Q9BDP0 218 73 -
NLPDVDLSKYITVIAE A8WEX9_CALJA 216 71 -
NLPDVDLSKYITVIAE A8WA68_CALJA 216 71 -
NLTDVDLGKYIPSIAE O97491 219 74 -
NFSDVDISKYIPTIAE Q9TV79 205 74 -
NFSDVDISKYIPTIAE Q9XS29 206 75 -
NLTDVDLGKYIPSIAE A5D7R0_BOVIN 215 72 -
NLTDVDLGKYIPSIAE FASA_BOVIN 215 72 -
MIKDVDLGKYITRIAE FASA_PIG 220 76 -
NASNLSLSKYIPRIAE Q6GT31_MOUSE 215 73 -
NASNLSLSKYIPRIAE FASA_MOUSE 215 73 -
NVSDVNLNKYIWRTAE FASA_RAT 212 70 -
NASNLSLSKYIPRIAE A1Y9B2_MOUSE 215 73 -