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PR01459

Identifier
KCNQCHANNEL  [View Relations]  [View Alignment]  
Accession
PR01459
No. of Motifs
3
Creation Date
29-NOV-2000
Title
KCNQ voltage-gated potassium channel family signature
Database References
PRINTS; PR00169 KCHANNEL; PR01460 KCNQ1CHANNEL; PR01461 KCNQ2CHANNEL
PRINTS; PR01462 KCNQ3CHANNEL
Literature References
1. MILLER, C.
An overview of the potassium channel family.
GENOME BIOL. 1(4) 1-5 (2000).
 
2. ASHCROFT, F.M.
Voltage-gated K+ channels.
IN ION CHANNELS AND DISEASE, ACADEMIC PRESS, 2000, PP.111-116.
 
3. SANGUINETTI, M.C.
Maximal function of minimal K+ channel subunits.
TRENDS PHARMACOL.SCI. 21 199-201 (2000).
 
4. WANG, Q., CURRAN, M.E., SPLAWSKI, I., BURN, T.C., MILLHOLLAND, J.M.,
VANRAAY, T.J., SHEN, J., TIMOTHY, K.W., VINCENT, G.M., DE JAGER, T.,
SCHWARTZ, P.J., TOUBIN, J.A., MOSS, A.J., ATKINSON, D.L., LANDES, G.M.,
CONNORS, T.D. AND KEATING, M.T. 
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause
cardiac arrhythmias.
NAT.GENET. 12(1) 17-23 (1996).
 
5. BIERVERT, C., SCHROEDER, B.C., KUBISCH, C., BERKOVIC, S.F., PROPPING, P.,
JENTSCH, T.J. AND STEINLEIN, O.K. 
A potassium channel mutation in neonatal human epilepsy.
SCIENCE 279 403-406 (1998).

Documentation
Potassium ion (K+) channels are a structurally diverse group of proteins
that facilitate the flow of K+ ions across cell membranes. They are
ubiquitous, being present in virtually all cell types. Activation of K+
channels tends to hyperpolarise cells, reducing the membrane's electrical
resistance, dampening nervous activity. In eukaryotic cells, K+ channels
are involved in neural signalling and generation of the cardiac rhythm, and
act as effectors in signal transduction pathways involving G protein-
coupled receptors (GPCRs). In prokaryotic cells, they play a role in the
maintenance of ionic homeostasis [1].
 
Structurally, KCNQ channels belong to the subfamily of K+ channels whose
subunits contain 6 transmembrane (TM) domains: these are the voltage-gated
K+ channels, the KCNQ channels, the EAG-like K+ channels and 3 kinds of 
Ca2+-activated K+ channel (BK, IK and SK) [2]. All K+ channels share a
characteristic sequence feature: a TMxTVGYG motif that resides between
the 2 C-terminal membrane-spanning helices, and forms the K+-selective 
pore domain [1].
 
KCNQ channels differ from other voltage-gated 6 TM helix channels, chiefly 
in that they possess no tetramerisation domain. Consequently, they rely on
interaction with accessory subunits, or form heterotetramers with other
members of the family [3]. Currently, 5 members of the KCNQ family are 
known. These have been found to be widely distributed within the body,
having been shown to be expressed in the heart, brain, pancreas, lung,
placenta and ear. They were initially cloned as a result of a search for 
proteins involved in cardiac arhythmia. Subsequently, mutations in other 
KCNQ family members have been shown to be responsible for some forms of
hereditary deafness [4] and benign familial neonatal epilepsy [5].
 
KCNQCHANNEL is a 3-element fingerprint that provides a signature for the
KCNQ voltage-gated potassium channel family. The fingerprint was derived
from an initial alignment of 25 sequences: the motifs were drawn from
conserved regions spanning the N-terminal third of the alignment, focusing
on those sections that characterise the KCNQ channels but distinguish them 
from other members of the K+ channel superfamily - motifs 1 and 2 span the
putative extracellular loop region between the putative TM domains 1 and 2;
and motif 3 spans the putative intracellular loop between TM domains 3 and
4. Two iterations on SPTR39_14f were required to reach convergence, at
which point a true set comprising 31 sequences was identified.
Summary Information
31 codes involving  3 elements
0 codes involving 2 elements
Composite Feature Index
3313131
2000
123
True Positives
CIK9_HUMAN    CIQ1_MOUSE    CIQ3_HUMAN    CIQ4_HUMAN    
O43526 O43796 O73925 O75580
O88943 O88944 O94787 O95845
Q18147 Q99454 Q9QWN9 Q9UMN8
Q9UMN9 Q9V5H7 Q9XWG9 Q9Z0N7
Q9Z240 Q9Z342 Q9Z343 Q9Z344
Q9Z345 Q9Z346 Q9Z347 Q9Z348
Q9Z349 Q9Z350 Q9Z351
Sequence Titles
CIK9_HUMAN  VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KQT-LIKE 1 (KV1.9) - HOMO SAPIENS (HUMAN). 
CIQ1_MOUSE VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KQT-LIKE 1 (KV1.9) - MUS MUSCULUS (MOUSE).
CIQ3_HUMAN VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KQT-LIKE 3 - Homo sapiens (Human).
CIQ4_HUMAN VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KQT-LIKE 4 - Homo sapiens (Human).
O43526 POTASSIUM CHANNEL - Homo sapiens (Human).
O43796 VOLTAGE GATED POTASSIUM CHANNEL - Homo sapiens (Human).
O73925 KVLQT POTASSIUM CHANNEL - Squalus acanthias (Spiny dogfish).
O75580 NEURONAL DELAYED-RECTIFIER VOLTAGE-GATED POTASSIUM CHANNEL SPLICE VARIANT - Homo sapiens (Human).
O88943 POTASSIUM CHANNEL - Rattus norvegicus (Rat).
O88944 POTASSIUM CHANNEL - Rattus norvegicus (Rat).
O94787 KVLQT1 ISOFORM1 PROTEIN - Homo sapiens (Human).
O95845 POTASSIUM CHANNEL - Homo sapiens (Human).
Q18147 HYPOTHETICAL 83.8 KDA PROTEIN C25B8.1 IN CHROMOSOME X - Caenorhabditis elegans.
Q99454 NEUROBLASTOMA-SPECIFIC POTASSIUM CHANNEL PROTEIN - Homo sapiens (Human).
Q9QWN9 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB000504 - Mus musculus (Mouse).
Q9UMN8 KVLQT1 PROTEIN - Homo sapiens (Human).
Q9UMN9 KVLQT1 PROTEIN - Homo sapiens (Human).
Q9V5H7 CG12215 PROTEIN - Drosophila melanogaster (Fruit fly).
Q9XWG9 Y54G9A.3 PROTEIN - Caenorhabditis elegans.
Q9Z0N7 KVLQT-1 POTASSIUM CHANNEL - Rattus norvegicus (Rat).
Q9Z240 POTASSIUM CHANNEL - Rattus norvegicus (Rat).
Q9Z342 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB000504 - Mus musculus (Mouse).
Q9Z343 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB000504 - Mus musculus (Mouse).
Q9Z344 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB000504 - Mus musculus (Mouse).
Q9Z345 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB000504 - Mus musculus (Mouse).
Q9Z346 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB000504 - Mus musculus (Mouse).
Q9Z347 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB000504 - Mus musculus (Mouse).
Q9Z348 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB000504 - Mus musculus (Mouse).
Q9Z349 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB000504 - Mus musculus (Mouse).
Q9Z350 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB000504 - Mus musculus (Mouse).
Q9Z351 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB000504 - Mus musculus (Mouse).
Scan History
SPTR39_14f 2  300  NSINGLE    
Initial Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
VFGVEYFVRIWAAGCCCRYR O43526 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z351 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z350 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z349 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z348 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z347 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z346 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z345 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z344 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z343 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z342 136 136 -
VFGVEYFVRIWAAGCCCRYR Q99454 136 136 -
VFGVEYFVRIWAAGCCCRYR O95845 136 136 -
VFGVEYFVRIWAAGCCCRYR O95845 136 136 -
VFGVEYFVRIWAAGCCCRYR O88943 136 136 -
VFGVEYFVRIWAAGCCCRYR O75580 136 136 -
VFGVEYFVRIWAAGCCCRYR O43796 136 136 -
VFGLEYIVRVWSAGCCCRYR CIQ4_HUMAN 142 142 -
IFGAEFALRIWAAGCCCRYK CIQ3_HUMAN 166 166 -
IFGAEFALRIWAAGCCCRYK O88944 167 167 -
IFGAEFALRIWAAGCCCRYK Q9Z240 129 129 -
FFGTEYIVRLWSAGCRSKYV O73925 159 159 -

Motif 2 width=20
Element Seqn Id St Int Rpt
GWRGRLKFARKPFCVIDIMV O43526 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z351 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z350 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z349 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z348 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z347 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z346 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z345 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z344 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z343 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z342 156 0 -
GWRGRLKFARKPFCVIDIMV Q99454 156 0 -
GWRGRLKFARKPFCVIDIMV O95845 156 0 -
GWRGRLKFARKPFCVIDIMV O95845 156 0 -
GWRGRLKFARKPFCVIDIMV O88943 156 0 -
GWRGRLKFARKPFCVIDIMV O75580 156 0 -
GWRGRLKFARKPFCVIDIMV O43796 156 0 -
GWQGRFRFARKPFCVIDFIV CIQ4_HUMAN 162 0 -
GWRGRLKFARKPLCMLDIFV CIQ3_HUMAN 186 0 -
GWRGRLKFARKPLCMLDIFV O88944 187 0 -
GWRGRLKFARKPLCMLDIFV Q9Z240 149 0 -
GFWGRLRFARKPISIIDLIV O73925 179 0 -

Motif 3 width=20
Element Seqn Id St Int Rpt
WKLLGSVVYAHSKELVTAWY O43526 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z351 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z350 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z349 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z348 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z347 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z346 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z345 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z344 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z343 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z342 218 42 -
WKLLGSVVYAHSKELVTAWY Q99454 218 42 -
WKLLGSVVYAHSKELVTAWY O95845 218 42 -
WKLLGSVVYAHSKELVTAWY O95845 218 42 -
WKLLGSVVYAHSKELVTAWY O88943 218 42 -
WKLLGSVVYAHSKELVTAWY O75580 218 42 -
WKLLGSVVYAHSKELVTAWY O43796 218 42 -
WKLLGSVVYAHSKELITAWY CIQ4_HUMAN 224 42 -
WKLLGSAICAHSKELITAWY CIQ3_HUMAN 247 41 -
WKLLGSAICAHSKELITAWY O88944 248 41 -
WKLLGSAICAHSKELITAWY Q9Z240 210 41 -
WRLLGSVVFIHRQELITTLY O73925 241 42 -
Final Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
VFGVEYFVRIWAAGCCCRYR O43526 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z351 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z350 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z349 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z348 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z347 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z346 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z345 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z344 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z343 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9Z342 136 136 -
VFGVEYFVRIWAAGCCCRYR Q9QWN9 136 136 -
VFGVEYFVRIWAAGCCCRYR Q99454 136 136 -
VFGVEYFVRIWAAGCCCRYR O95845 136 136 -
VFGVEYFVRIWAAGCCCRYR O95845 136 136 -
VFGVEYFVRIWAAGCCCRYR O88943 136 136 -
VFGVEYFVRIWAAGCCCRYR O75580 136 136 -
VFGVEYFVRIWAAGCCCRYR O43796 136 136 -
VFGLEYIVRVWSAGCCCRYR CIQ4_HUMAN 142 142 -
IFGAEFALRIWAAGCCCRYK CIQ3_HUMAN 166 166 -
IFGAEFALRIWAAGCCCRYK O88944 167 167 -
IFGAEFALRIWAAGCCCRYK Q9Z240 129 129 -
FFGTEYVVRLWSAGCRSKYV CIK9_HUMAN 166 166 -
FFGTEYVVRLWSAGCRSKYV O94787 166 166 -
FFGTEYVVRLWSAGCRSKYV CIQ1_MOUSE 101 101 -
FFGTEYVVRLWSAGCRSKYV Q9Z0N7 166 166 -
FFGTEYIVRLWSAGCRSKYV O73925 159 159 -
FFXTEYVVRLWSAGCRSKYV Q9UMN8 39 39 -
FFXTEYVVRLWSAGCRSKYV Q9UMN9 166 166 -
WLATEYICRVWSAGCRSRYR Q18147 168 168 -
WFTMEFGARLWSSGCRSRYQ Q9V5H7 83 83 -
FFSVEFIVRLWSAGCRSKYI Q9XWG9 63 63 -

Motif 2 width=20
Element Seqn Id St Int Rpt
GWRGRLKFARKPFCVIDIMV O43526 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z351 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z350 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z349 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z348 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z347 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z346 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z345 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z344 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z343 156 0 -
GWRGRLKFARKPFCVIDIMV Q9Z342 156 0 -
GWRGRLKFARKPFCVIDIMV Q9QWN9 156 0 -
GWRGRLKFARKPFCVIDIMV Q99454 156 0 -
GWRGRLKFARKPFCVIDIMV O95845 156 0 -
GWRGRLKFARKPFCVIDIMV O95845 156 0 -
GWRGRLKFARKPFCVIDIMV O88943 156 0 -
GWRGRLKFARKPFCVIDIMV O75580 156 0 -
GWRGRLKFARKPFCVIDIMV O43796 156 0 -
GWQGRFRFARKPFCVIDFIV CIQ4_HUMAN 162 0 -
GWRGRLKFARKPLCMLDIFV CIQ3_HUMAN 186 0 -
GWRGRLKFARKPLCMLDIFV O88944 187 0 -
GWRGRLKFARKPLCMLDIFV Q9Z240 149 0 -
GLWGRLRFARKPISIIDLIV CIK9_HUMAN 186 0 -
GLWGRLRFARKPISIIDLIV O94787 186 0 -
GIWGRLRFARKPISIIDLIV CIQ1_MOUSE 121 0 -
GIWGRLRFARKPISIIDLIV Q9Z0N7 186 0 -
GFWGRLRFARKPISIIDLIV O73925 179 0 -
GLWGRLRFARKPISIIDLIV Q9UMN8 59 0 -
GLWGRLRFARKPISIIDLIV Q9UMN9 186 0 -
GISGRIRFATSAYCVIDIIV Q18147 188 0 -
GCLGRLKFVKRPFCIIDIVT Q9V5H7 103 0 -
GVYGRLKFVRKPITLIGRFG Q9XWG9 83 0 -

Motif 3 width=20
Element Seqn Id St Int Rpt
WKLLGSVVYAHSKELVTAWY O43526 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z351 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z350 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z349 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z348 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z347 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z346 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z345 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z344 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z343 218 42 -
WKLLGSVVYAHSKELVTAWY Q9Z342 218 42 -
WKLLGSVVYAHSKELVTAWY Q9QWN9 218 42 -
WKLLGSVVYAHSKELVTAWY Q99454 218 42 -
WKLLGSVVYAHSKELVTAWY O95845 218 42 -
WKLLGSVVYAHSKELVTAWY O95845 218 42 -
WKLLGSVVYAHSKELVTAWY O88943 218 42 -
WKLLGSVVYAHSKELVTAWY O75580 218 42 -
WKLLGSVVYAHSKELVTAWY O43796 218 42 -
WKLLGSVVYAHSKELITAWY CIQ4_HUMAN 224 42 -
WKLLGSAICAHSKELITAWY CIQ3_HUMAN 247 41 -
WKLLGSAICAHSKELITAWY O88944 248 41 -
WKLLGSAICAHSKELITAWY Q9Z240 210 41 -
WRLLGSVVFIHRQELITTLY CIK9_HUMAN 248 42 -
WRLLGSVVFIHRQELITTLY O94787 248 42 -
WRLLGSVVFIHRQELITTLY CIQ1_MOUSE 183 42 -
WRLLGSVVFIHRQELITTLY Q9Z0N7 248 42 -
WRLLGSVVFIHRQELITTLY O73925 241 42 -
WRLLGSVVFIHRQELITTLY Q9UMN8 121 42 -
WRLLGSVVFIHRQELITTLY Q9UMN9 248 42 -
WKLLGSVVWAHRQELLTTVY Q18147 250 42 -
WKLLGSVVYAHRQQELITTM Q9V5H7 165 42 -
RRLLGSVVFIHRQELITTLY Q9XWG9 226 123 -