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PR01292

Identifier
RETNOICACIDR  [View Relations]  [View Alignment]  
Accession
PR01292
No. of Motifs
10
Creation Date
13-FEB-2000
Title
Retinoic acid receptor (1B nuclear receptor) signature
Database References

PDB; 3LBD; 4LBD
SCOP; 3LBD; 4LBD
CATH; 3LBD; 4LBD
Literature References
1. NUCLEAR RECEPTORS NOMENCLATURE COMMITTEE
A unified nomenclature system for the nuclear receptor superfamily.
CELL 97 161-163 (1999).
 
2. NISHIKAWA, J-I., KITAURA, M., IMAGAWA, M. AND NISHIHARA, T.
Vitamin D receptor contains multiple dimerisation interfaces that
are functionally different.
NUCLEIC ACIDS RES. 23(4) 606-611 (1995).
 
3. DE VOS, P., SCHMITT, J., VERHOEVEN, G. AND STUNNENBERG, G.
Human androgen receptor expressed in HeLa cells activates transcription
in vitro.
NUCLEIC ACIDS RES. 22(7) 1161-1166 (1994).
 
4. LEHMANN, J.M., HOFFMANN, B. AND PFAHL, M.
Genomic organization of the retinoic acid receptor gamma gene.
NUCLEIC ACIDS RES. 19 573-578 (1991). 
 
5. KRUST, A., KASTNER, P., PETKOVICH, M., ZELENT, A. AND CHAMBON, P.
A third human retinoic acid receptor, hRAR-gamma.
PROC.NATL.ACAD.SCI.U.S.A. 86 5310-5314 (1989). 
 
6. RENAUD, J.P., ROCHEL, N., RUFF, M., VIVAT, V., CHAMBON, P., 
GRONEMEYER, H. AND MORAS, D. 
Crystal structure of the RAR-gamma ligand-binding domain bound to 
all-trans retinoic acid.
NATURE 378 681-689 (1995). 

Documentation
Steroid or nuclear hormone receptors (NRs) constitute an important super-
family of transcription regulators that are involved in widely diverse 
physiological functions, including control of embryonic development, cell
differentiation and homeostasis [1]. Members of the superfamily include the
steroid hormone receptors and receptors for thyroid hormone, retinoids, 
1,25-dihydroxy-vitamin D3 and a variety of other ligands. The proteins 
function as dimeric molecules in nuclei to regulate the transcription of 
target genes in a ligand-responsive manner [2,3]. In addition to C-terminal
ligand-binding domains, these nuclear receptors contain a highly-conserved,
N-terminal zinc-finger that mediates specific binding to target DNA 
sequences, termed ligand-responsive elements. In the absence of ligand,
steroid hormone receptors are thought to be weakly associated with nuclear
components; hormone binding greatly increases receptor affinity.
 
NRs are extremely important in medical research, a large number of them
being implicated in diseases such as cancer, diabetes, hormone resistance
syndromes, etc. [1]. While several NRs act as ligand-inducible transcription
factors, many do not yet have a defined ligand and are accordingly termed 
"orphan" receptors. During the last decade, more than 300 NRs have been
described, many of which are orphans, which cannot easily be named due to 
current nomenclature confusions in the literature. However, a new system 
has recently been introduced in an attempt to rationalise the increasingly 
complex set of names used to describe superfamily members [1].
 
The retinoic acid receptors (RAR) belong to the large family of ligand 
responsive gene regulatory proteins that includes receptors for steroid and
thyroid hormones [4]. These proteins contain two highly conserved domains
that are involved in determining their DNA and ligand-binding activities [4].
Three distinct RARs have been identified (termed RAR alpha, beta, and gamma)
and are encoded by genes on separate chromosomes [4]. Additional isoforms
of the receptors have been described, all of which differ in the N-terminal
regions [4]. Comparison of the amino acid sequences of human and mouse RARs
indicates that interspecies conservation in members of the RAR subfamily 
(either alpha, beta or gamma) is much higher than conservation of the
receptors within species [5]. These observations indicate that RAR-alpha, 
-beta and -gamma may perform specific functions [5]. hRAR-gamma RNA has 
been shown to be the predominant RAR RNA species in human skin, suggesting
that hRAR-gamma mediates some of the retinoid effects in this tissue [4]. 
 
The crystal structure of the ligand-binding domain (LBD) of the hRAR-gamma
bound to all-trans retinoic acid has been determined to 2.0A resolution [6].
Overall, the fold is similar to that of the human RXR-alpha apo-LBD, except
for the C-terminal portion, which folds back towards the LBD core, 
contributing to the hydrophobic ligand pocket and `sealing' its entry site
[6]. A `mouse trap' mechanism is thus proposed, whereby a ligand-induced 
conformational transition re-positions the amphipathic alpha-helix of the
activating domain and forms a transcriptionally active receptor [6]. 
 
RETNOICACIDR is a 10 element fingerprint that provides a signature for
retinoic acid (RAR) receptors. The fingerprint was derived from an initial
alignment of 12 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length, focusing on those sections
that characterise the retinoic acid receptors but distinguish them from
the rest of the steroid hormone receptor superfamily - motif 1 lies towards
the C-terminus of the modulating domain; motifs 2 and 3 lie immediately 
C-terminal to the zinc finger domain within the hinge region; and motifs
4-10 span the ligand-binding domain - motif 4 includes helix 2; motif 5
encodes helix 3; motif 6 spans strands 1-3 and helix 6; motif 7 spans the
C-terminal half of helix 8 and helix 9; motif 8 encodes helix 11; motif 9
encodes the C-terminus of helix 12; and motif 10 spans helix 13. Two
iterations on SPTR37_10f were required to reach convergence, at which
point a true set comprising 26 sequences was identified.
Summary Information
26 codes involving 10 elements
0 codes involving 9 elements
0 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
1026262626262626262626
90000000000
80000000000
70000000000
60000000000
50000000000
40000000000
30000000000
20000000000
12345678910
True Positives
P79878        P97513        Q15156        Q90271        
Q90272 Q90966 Q90967 Q90968
Q91155 Q92019 RRA1_HUMAN RRA_MOUSE
RRA_NOTVI RRA_XENLA RRB1_CHICK RRB2_CHICK
RRB2_HUMAN RRB_MOUSE RRD1_NOTVI RRD2_NOTVI
RRG1_HUMAN RRG1_MOUSE RRG1_XENLA RRG2_HUMAN
RRG2_MOUSE RRG2_XENLA
Sequence Titles
P79878      RETINOIC ACID RECEPTOR GAMMA ISOFORM 2.1 - XENOPUS LAEVIS (AFRICAN CLAWED FROG). 
P97513 RETINOIC ACID RECEPTOR-ALPHA - MUS SPRETUS (WESTERN WILD MOUSE).
Q15156 PML-RAR PROTEIN - HOMO SAPIENS (HUMAN).
Q90271 RETINOIC ACID RECEPTOR ALPHA-2.A - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
Q90272 RETINOIC ACID RECEPTOR ALPHA-2.B - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
Q90966 RETINOIC ACID RECEPTOR ALPHA 1 ISOFORM - GALLUS GALLUS (CHICKEN).
Q90967 RETINOIC ACID RECPTOR ALPHA ISOFORM 2-1 - GALLUS GALLUS (CHICKEN).
Q90968 RETINOIC ACID RECEPTOR GAMMA 2 ISOFORM - GALLUS GALLUS (CHICKEN).
Q91155 RETINOIC ACID RECEPTOR ALPHA 2 - NOTOPHTHALMUS VIRIDESCENS (EASTERN NEWT) (TRITU
Q92019 RETINOIC ACID RECEPTOR - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
RRA1_HUMAN RETINOIC ACID RECEPTOR ALPHA-1 (RAR-ALPHA-1) - HOMO SAPIENS (HUMAN).
RRA_MOUSE RETINOIC ACID RECEPTOR ALPHA (RAR-ALPHA) - MUS MUSCULUS (MOUSE).
RRA_NOTVI RETINOIC ACID RECEPTOR ALPHA (RAR-ALPHA) - NOTOPHTHALMUS VIRIDESCENS (EASTERN NE
RRA_XENLA RETINOIC ACID RECEPTOR ALPHA (RAR-ALPHA) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
RRB1_CHICK RETINOIC ACID RECEPTOR BETA-1 (RAR-BETA-1) - GALLUS GALLUS (CHICKEN).
RRB2_CHICK RETINOIC ACID RECEPTOR BETA-2 (RAR-BETA-2) - GALLUS GALLUS (CHICKEN).
RRB2_HUMAN RETINOIC ACID RECEPTOR BETA-2 (RAR-BETA-2) (RAR-EPSILON) - HOMO SAPIENS (HUMAN).
RRB_MOUSE RETINOIC ACID RECEPTOR BETA (RAR-BETA) - MUS MUSCULUS (MOUSE).
RRD1_NOTVI RETINOIC ACID RECEPTOR DELTA-1 (RAR-DELTA-1) - NOTOPHTHALMUS VIRIDESCENS (EASTER
RRD2_NOTVI RETINOIC ACID RECEPTOR DELTA-2 (RAR-DELTA-2) - NOTOPHTHALMUS VIRIDESCENS (EASTER
RRG1_HUMAN RETINOIC ACID RECEPTOR GAMMA-1 (RAR-GAMMA-1) - HOMO SAPIENS (HUMAN).
RRG1_MOUSE RETINOIC ACID RECEPTOR GAMMA-A (RAR-GAMMA-A) - MUS MUSCULUS (MOUSE).
RRG1_XENLA RETINOIC ACID RECEPTOR GAMMA-1 (RAR-GAMMA-1) - XENOPUS LAEVIS (AFRICAN CLAWED FR
RRG2_HUMAN RETINOIC ACID RECEPTOR GAMMA-2 (RAR-GAMMA-2) - HOMO SAPIENS (HUMAN).
RRG2_MOUSE RETINOIC ACID RECEPTOR GAMMA-B (RAR-GAMMA-B) - MUS MUSCULUS (MOUSE).
RRG2_XENLA RETINOIC ACID RECEPTOR GAMMA-2 (RAR-GAMMA-2) - XENOPUS LAEVIS (AFRICAN CLAWED FR
Scan History
SPTR37_10f 1  50   NSINGLE    
Initial Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
SVETQSTSSEEMVPSSPS RRG1_HUMAN 62 62 -
SVETQSTSSEEMVPSSPS RRG1_MOUSE 62 62 -
SVETQSTSSEEMVPSSPS RRG2_HUMAN 51 51 -
SVETQSTSSEEMVPSSPS RRG2_MOUSE 51 51 -
SVETQSTSSEEMVPSSPS RRD1_NOTVI 115 115 -
SVETQSTSSEEMVPSSPS RRD2_NOTVI 51 51 -
TVETQSTSSEEMVPSSPS RRG1_XENLA 82 82 -
SVETQSTSSEEMVPSSPS RRG2_XENLA 48 48 -
SIETQSTSSEELVPSPPS RRB2_HUMAN 53 53 -
TVETQSTSSEELVPSPPS RRB1_CHICK 60 60 -
TIETQSTSSEEIVPSPPS RRA_NOTVI 59 59 -
TIETQSSSSEEIVPSPPS RRA1_HUMAN 60 60 -

Motif 2 width=14
Element Seqn Id St Int Rpt
SKEAVRNDRNKKKK RRG1_HUMAN 156 76 -
SKEAVRNDRNKKKK RRG1_MOUSE 156 76 -
SKEAVRNDRNKKKK RRG2_HUMAN 145 76 -
SKEAVRNDRNKKKK RRG2_MOUSE 145 76 -
SKEAVRNDRNKKKK RRD1_NOTVI 209 76 -
SKEAVRNDRNKKKK RRD2_NOTVI 145 76 -
SKEAVRNDRNKKKK RRG1_XENLA 176 76 -
SKEAVRNDRNKKKK RRG2_XENLA 142 76 -
SKESVRNDRNKKKK RRB2_HUMAN 147 76 -
SKESVRNDRNKKKK RRB1_CHICK 154 76 -
SKESVRNDRNKKKK RRA_NOTVI 153 76 -
SKESVRNDRNKKKK RRA1_HUMAN 154 76 -

Motif 3 width=25
Element Seqn Id St Int Rpt
DSYELSPQLEELITKVSKAHQETFP RRG1_HUMAN 178 8 -
DSYELSPQLEELITKVSKAHQETFP RRG1_MOUSE 178 8 -
DSYELSPQLEELITKVSKAHQETFP RRG2_HUMAN 167 8 -
DSYELSPQLEELITKVSKAHQETFP RRG2_MOUSE 167 8 -
DSYEMPPEMEALIQKVSKAHQETFP RRD1_NOTVI 231 8 -
DSYEMPPEMEALIQKVSKAHQETFP RRD2_NOTVI 167 8 -
DSYEMPPEMEELIQKVSKAHQETFP RRG1_XENLA 199 9 -
DSYEMPPEMEELIQKVSKAHQETFP RRG2_XENLA 165 9 -
ESYEMTAELDDLTEKIRKAHQETFP RRB2_HUMAN 169 8 -
ENYEMTAELDDLTEKIRKAHQETFP RRB1_CHICK 176 8 -
ESYIITPEVEDLVEKVRKAHQETFP RRA_NOTVI 176 9 -
ESYTLTPEVGELIEKVRKAHQETFP RRA1_HUMAN 176 8 -

Motif 4 width=17
Element Seqn Id St Int Rpt
SLCQLGKYTTNSSADHR RRG1_HUMAN 203 0 -
SLCQLGKYTTNSSADHR RRG1_MOUSE 203 0 -
SLCQLGKYTTNSSADHR RRG2_HUMAN 192 0 -
SLCQLGKYTTNSSADHR RRG2_MOUSE 192 0 -
SLCQLGKYTTNSSADHR RRD1_NOTVI 256 0 -
SLCQLGKYTTNSSADHR RRD2_NOTVI 192 0 -
SLCQLGKYTTNSSADQR RRG1_XENLA 224 0 -
SLCQLGKYTTNSSADQR RRG2_XENLA 190 0 -
SLCQLGKYTTNSSADHR RRB2_HUMAN 194 0 -
SLCQLGKYTTNSSADHR RRB1_CHICK 201 0 -
ALCQLGKYTTNNSSEER RRA_NOTVI 201 0 -
ALCQLGKYTTNNSSEQR RRA1_HUMAN 201 0 -

Motif 5 width=18
Element Seqn Id St Int Rpt
GLWDKFSELATKCIIKIV RRG1_HUMAN 225 5 -
GLWDKFSELATKCIIKIV RRG1_MOUSE 225 5 -
GLWDKFSELATKCIIKIV RRG2_HUMAN 214 5 -
GLWDKFSELATKCIIKIV RRG2_MOUSE 214 5 -
GLWHKFSELATKCIIKIV RRD1_NOTVI 278 5 -
GLWHKFSELATKCIIKIV RRD2_NOTVI 214 5 -
GLWDKFSELSTKCIIKIV RRG1_XENLA 246 5 -
GLWDKFSELSTKCIIKIV RRG2_XENLA 212 5 -
GLWDKFSELATKCIIKIV RRB2_HUMAN 216 5 -
GLWDKFSELATKCIIKIV RRB1_CHICK 223 5 -
DLWDKFSELSTKCIIKTV RRA_NOTVI 223 5 -
DLWDKFSELSTKCIIKTV RRA1_HUMAN 223 5 -

Motif 6 width=25
Element Seqn Id St Int Rpt
CTRYTPEQDTMTFSDGLTLNRTQMH RRG1_HUMAN 276 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRG1_MOUSE 276 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRG2_HUMAN 265 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRG2_MOUSE 265 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRD1_NOTVI 329 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRD2_NOTVI 265 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRG1_XENLA 297 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRG2_XENLA 263 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRB2_HUMAN 267 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRB1_CHICK 274 33 -
CTRYTPDQDTMTFSDGLTLNRTQMH RRA_NOTVI 274 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRA1_HUMAN 274 33 -

Motif 7 width=13
Element Seqn Id St Int Rpt
AFAGQLLPLEMDD RRG1_HUMAN 313 12 -
AFAGQLLPLEMDD RRG1_MOUSE 313 12 -
AFAGQLLPLEMDD RRG2_HUMAN 302 12 -
AFAGQLLPLEMDD RRG2_MOUSE 302 12 -
AFAEQLLPLEMDD RRD1_NOTVI 366 12 -
AFAEQLLPLEMDD RRD2_NOTVI 302 12 -
SFADQLLPLEMDD RRG1_XENLA 334 12 -
SFADQLLPLEMDD RRG2_XENLA 300 12 -
TFANQLLPLEMDD RRB2_HUMAN 304 12 -
TFANQLLPLEMDD RRB1_CHICK 311 12 -
AFANQLLPLEMDD RRA_NOTVI 311 12 -
AFANQLLPLEMDD RRA1_HUMAN 311 12 -

Motif 8 width=22
Element Seqn Id St Int Rpt
DLEEPEKVDKLQEPLLEALRLY RRG1_HUMAN 343 17 -
DLEEPEKVDKLQEPLLEALRLY RRG1_MOUSE 343 17 -
DLEEPEKVDKLQEPLLEALRLY RRG2_HUMAN 332 17 -
DLEEPEKVDKLQEPLLEALRLY RRG2_MOUSE 332 17 -
DLEEPEKVDKLQEPLLEALKIY RRD1_NOTVI 396 17 -
DLEEPEKVDKLQEPLLEALKIY RRD2_NOTVI 332 17 -
DLEEPEKVEKLQEPLLEALKFY RRG1_XENLA 364 17 -
DLEEPEKVEKLQEPLLEGLKFY RRG2_XENLA 330 17 -
DLEEPTKVDKLQEPLLEALKIY RRB2_HUMAN 334 17 -
DLEEPMKVDKLQEPLLEALKIY RRB1_CHICK 341 17 -
DLEQPDKVDKLQEPLLEALKIY RRA_NOTVI 341 17 -
DLEQPDRVDMLQEPLLEALKVY RRA1_HUMAN 341 17 -

Motif 9 width=16
Element Seqn Id St Int Rpt
RGISTKGAERAITLKM RRG1_HUMAN 387 22 -
RGISTKGAERAITLKM RRG1_MOUSE 387 22 -
RGISTKGAERAITLKM RRG2_HUMAN 376 22 -
RGISTKGAERAITLKM RRG2_MOUSE 376 22 -
RGISTKGAERAITLKM RRD1_NOTVI 440 22 -
RGISTKGAERAITLKM RRD2_NOTVI 376 22 -
RGISTKGAERAITLKL RRG1_XENLA 408 22 -
RGISTKGAERAITLKL RRG2_XENLA 374 22 -
RSISAKGAERVITLKM RRB2_HUMAN 378 22 -
RSISAKGAERVITLKM RRB1_CHICK 385 22 -
RSISAKGAERVITLKM RRA_NOTVI 385 22 -
RSISAKGAERVITLKM RRA1_HUMAN 385 22 -

Motif 10 width=14
Element Seqn Id St Int Rpt
PLIREMLENPEMFE RRG1_HUMAN 410 7 -
PLIREMLENPEMFE RRG1_MOUSE 410 7 -
PLIREMLENPEMFE RRG2_HUMAN 399 7 -
PLIREMLENPEMFE RRG2_MOUSE 399 7 -
PLIREMLENPEAFE RRD1_NOTVI 463 7 -
PLIREMLENPEAFE RRD2_NOTVI 399 7 -
PLIREMLENPEAFE RRG1_XENLA 431 7 -
PLIREMLENPEAFE RRG2_XENLA 397 7 -
PLIQEMLENSEGHE RRB2_HUMAN 401 7 -
PLIQEMLENSEGHE RRB1_CHICK 408 7 -
PLIQEMLENSEGLD RRA_NOTVI 408 7 -
PLIQEMLENSEGLD RRA1_HUMAN 408 7 -
Final Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
SVETQSTSSEEMVPSSPS RRG1_HUMAN 62 62 -
SVETQSTSSEEMVPSSPS RRG1_MOUSE 62 62 -
SVETQSTSSEEMVPSSPS RRG2_HUMAN 51 51 -
SVETQSTSSEEMVPSSPS RRG2_MOUSE 51 51 -
SVETQSTSSEEMVPSSPS RRD1_NOTVI 115 115 -
SVETQSTSSEEMVPSSPS RRD2_NOTVI 51 51 -
SVETQSTSSEEMVPSSPS P79878 48 48 -
TVETQSTSSEEMVPSSPS RRG1_XENLA 82 82 -
SVETQSTSSEEMVPSSPS RRG2_XENLA 48 48 -
SIETQSTSSEELVPSPPS RRB2_HUMAN 53 53 -
SVETQSTSSEELVPSPPS RRB2_CHICK 53 53 -
TVETQSTSSEELVPSPPS RRB1_CHICK 60 60 -
AIETQSTSSEELVPSPPS RRB_MOUSE 87 87 -
SVETQSTSSEEIVPSPPS Q90967 53 53 -
SIETQSTSSEEIVPSPPS Q91155 53 53 -
TVETQSTSSEEIVPSPPS Q90966 60 60 -
TIETQSTSSEEIVPSPPS RRA_NOTVI 59 59 -
TIETQSSSSEEIVPSPPS P97513 60 60 -
TIETQSSSSEEIVPSPPS RRA_MOUSE 60 60 -
TIETQSSSSEEIVPSPPS RRA1_HUMAN 60 60 -
AIETQSSSSEEIVPSPPS Q15156 395 395 -
SIETQSTSSEEIVPSPPS Q92019 49 49 -
GAETQSSSSEEMVPNSPS Q90968 52 52 -
SVETQSTSSEEIVPSPPS Q90272 55 55 -
SIETQSTSSEEIVPSPPS Q90271 47 47 -
TIETQSTSSEEIVPSPPT RRA_XENLA 60 60 -

Motif 2 width=14
Element Seqn Id St Int Rpt
SKEAVRNDRNKKKK RRG1_HUMAN 156 76 -
SKEAVRNDRNKKKK RRG1_MOUSE 156 76 -
SKEAVRNDRNKKKK RRG2_HUMAN 145 76 -
SKEAVRNDRNKKKK RRG2_MOUSE 145 76 -
SKEAVRNDRNKKKK RRD1_NOTVI 209 76 -
SKEAVRNDRNKKKK RRD2_NOTVI 145 76 -
SKEAVRNDRNKKKK P79878 142 76 -
SKEAVRNDRNKKKK RRG1_XENLA 176 76 -
SKEAVRNDRNKKKK RRG2_XENLA 142 76 -
SKESVRNDRNKKKK RRB2_HUMAN 147 76 -
SKESVRNDRNKKKK RRB2_CHICK 147 76 -
SKESVRNDRNKKKK RRB1_CHICK 154 76 -
SKESVRNDRNKKKK RRB_MOUSE 181 76 -
SKESVRNDRNKKKK Q90967 147 76 -
SKESVRNDRNKKKK Q91155 147 76 -
SKESVRNDRNKKKK Q90966 154 76 -
SKESVRNDRNKKKK RRA_NOTVI 153 76 -
SKESVRNDRNKKKK P97513 154 76 -
SKESVRNDRNKKKK RRA_MOUSE 154 76 -
SKESVRNDRNKKKK RRA1_HUMAN 154 76 -
SKESVRNDRNKKKK Q15156 489 76 -
SKESVRNDRNKKKK Q92019 143 76 -
SKEAVRNDRNKKKK Q90968 146 76 -
SKESVRNDRNKRKK Q90272 149 76 -
SKESVRNDRNKKKK Q90271 141 76 -
SKESVRNDRNKKKK RRA_XENLA 154 76 -

Motif 3 width=25
Element Seqn Id St Int Rpt
DSYELSPQLEELITKVSKAHQETFP RRG1_HUMAN 178 8 -
DSYELSPQLEELITKVSKAHQETFP RRG1_MOUSE 178 8 -
DSYELSPQLEELITKVSKAHQETFP RRG2_HUMAN 167 8 -
DSYELSPQLEELITKVSKAHQETFP RRG2_MOUSE 167 8 -
DSYEMPPEMEALIQKVSKAHQETFP RRD1_NOTVI 231 8 -
DSYEMPPEMEALIQKVSKAHQETFP RRD2_NOTVI 167 8 -
DSYEMPPEMEELIQKVSKAHQETFP P79878 165 9 -
DSYEMPPEMEELIQKVSKAHQETFP RRG1_XENLA 199 9 -
DSYEMPPEMEELIQKVSKAHQETFP RRG2_XENLA 165 9 -
ESYEMTAELDDLTEKIRKAHQETFP RRB2_HUMAN 169 8 -
ENYEMTAELDDLTEKIRKAHQETFP RRB2_CHICK 169 8 -
ENYEMTAELDDLTEKIRKAHQETFP RRB1_CHICK 176 8 -
ESYEMTAELDDLTEKIRKAHQETFP RRB_MOUSE 203 8 -
ESYIVTPEVEELIEKVRKAHQETFP Q90967 169 8 -
ESYIITPEVEDLVEKVRKAHQETFP Q91155 170 9 -
ESYIVTPEVEELIEKVRKAHQETFP Q90966 176 8 -
ESYIITPEVEDLVEKVRKAHQETFP RRA_NOTVI 176 9 -
ESYTLTPEVGELIEKVRKAHQETFP P97513 176 8 -
ESYTLTPEVGELIEKVRKAHQETFP RRA_MOUSE 176 8 -
ESYTLTPEVGELIEKVRKAHQETFP RRA1_HUMAN 176 8 -
ESYTLTPEVGELIEKVRKAHQETFP Q15156 511 8 -
ESYVLSPETQDLIEKVRKAHKETFP Q92019 165 8 -
DSPELSPALEELIQKVSRAHQETFP Q90968 167 7 -
ENYVLSPDTEKMIEQVRKAHQETFP Q90272 171 8 -
ENYTLSPDTEQMIDRVRKAHQETFP Q90271 163 8 -
ESYILSPETQDLIEKVQKAHQETFP RRA_XENLA 176 8 -

Motif 4 width=17
Element Seqn Id St Int Rpt
SLCQLGKYTTNSSADHR RRG1_HUMAN 203 0 -
SLCQLGKYTTNSSADHR RRG1_MOUSE 203 0 -
SLCQLGKYTTNSSADHR RRG2_HUMAN 192 0 -
SLCQLGKYTTNSSADHR RRG2_MOUSE 192 0 -
SLCQLGKYTTNSSADHR RRD1_NOTVI 256 0 -
SLCQLGKYTTNSSADHR RRD2_NOTVI 192 0 -
SLCQLGKYTTNSSADQR P79878 190 0 -
SLCQLGKYTTNSSADQR RRG1_XENLA 224 0 -
SLCQLGKYTTNSSADQR RRG2_XENLA 190 0 -
SLCQLGKYTTNSSADHR RRB2_HUMAN 194 0 -
SLCQLGKYTTNSSADHR RRB2_CHICK 194 0 -
SLCQLGKYTTNSSADHR RRB1_CHICK 201 0 -
SLCQLGKYTTNSSADHR RRB_MOUSE 228 0 -
ALCQLGKYTTNNSSEQR Q90967 194 0 -
ALCQLGKYTTNNSSEER Q91155 195 0 -
ALCQLGKYTTNNSSEQR Q90966 201 0 -
ALCQLGKYTTNNSSEER RRA_NOTVI 201 0 -
ALCQLGKYTTNNSSEQR P97513 201 0 -
ALCQLGKYTTNNSSEQR RRA_MOUSE 201 0 -
ALCQLGKYTTNNSSEQR RRA1_HUMAN 201 0 -
ALCQLGKYTTNNSSEQR Q15156 536 0 -
ALCQLGKYTTNFSSEER Q92019 190 0 -
SLCQLGKYTMSSSAQHR Q90968 192 0 -
SLCQLGKYTTNNSADHR Q90272 196 0 -
SLCQLGKYTTSNSSERR Q90271 188 0 -
ALCQLGKYTTSFSSEQR RRA_XENLA 201 0 -

Motif 5 width=18
Element Seqn Id St Int Rpt
GLWDKFSELATKCIIKIV RRG1_HUMAN 225 5 -
GLWDKFSELATKCIIKIV RRG1_MOUSE 225 5 -
GLWDKFSELATKCIIKIV RRG2_HUMAN 214 5 -
GLWDKFSELATKCIIKIV RRG2_MOUSE 214 5 -
GLWHKFSELATKCIIKIV RRD1_NOTVI 278 5 -
GLWHKFSELATKCIIKIV RRD2_NOTVI 214 5 -
GLWDKFSELSTKCIIKIV P79878 212 5 -
GLWDKFSELSTKCIIKIV RRG1_XENLA 246 5 -
GLWDKFSELSTKCIIKIV RRG2_XENLA 212 5 -
GLWDKFSELATKCIIKIV RRB2_HUMAN 216 5 -
GLWDKFSELATKCIIKIV RRB2_CHICK 216 5 -
GLWDKFSELATKCIIKIV RRB1_CHICK 223 5 -
GLWDKFSELATKCIIKIV RRB_MOUSE 250 5 -
DLWDKFSELSTKCIIKTV Q90967 216 5 -
DLWDKFSELSTKCIIKTV Q91155 217 5 -
DLWDKFSELSTKCIIKTV Q90966 223 5 -
DLWDKFSELSTKCIIKTV RRA_NOTVI 223 5 -
DLWDKFSELSTKCIIKTV P97513 223 5 -
DLWDKFSELSTKCIIKTV RRA_MOUSE 223 5 -
DLWDKFSELSTKCIIKTV RRA1_HUMAN 223 5 -
DLWDKFSELSTKCIIKTV Q15156 558 5 -
DLWDKFSELSTKCIIKTV Q92019 212 5 -
GLWDKFSELATKCIIKIV Q90968 214 5 -
DLWDKFSELSTKCIIKTV Q90272 218 5 -
DLWDKFSELSTKCIIKTV Q90271 210 5 -
DLWDKFSELSTKCIIKTV RRA_XENLA 223 5 -

Motif 6 width=25
Element Seqn Id St Int Rpt
CTRYTPEQDTMTFSDGLTLNRTQMH RRG1_HUMAN 276 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRG1_MOUSE 276 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRG2_HUMAN 265 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRG2_MOUSE 265 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRD1_NOTVI 329 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRD2_NOTVI 265 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH P79878 263 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRG1_XENLA 297 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRG2_XENLA 263 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRB2_HUMAN 267 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRB2_CHICK 267 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRB1_CHICK 274 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRB_MOUSE 301 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH Q90967 267 33 -
CTRYTPDQDTMTFSDGLTLNRTQMH Q91155 268 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH Q90966 274 33 -
CTRYTPDQDTMTFSDGLTLNRTQMH RRA_NOTVI 274 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH P97513 274 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRA_MOUSE 274 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH RRA1_HUMAN 274 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH Q15156 609 33 -
CTRYTPDQDTMTFSDGLTLNRTQMH Q92019 263 33 -
CTRYTLEQDTMTFSDGLTLNRTQMH Q90968 265 33 -
CTRYTPDQDTMTFSDGLTLNRTQMH Q90272 269 33 -
CTRYTPEQDTMTFSDGLTLNRTQMH Q90271 261 33 -
CTRYTPDQDTMTFSDGLTLNRTQMH RRA_XENLA 274 33 -

Motif 7 width=13
Element Seqn Id St Int Rpt
AFAGQLLPLEMDD RRG1_HUMAN 313 12 -
AFAGQLLPLEMDD RRG1_MOUSE 313 12 -
AFAGQLLPLEMDD RRG2_HUMAN 302 12 -
AFAGQLLPLEMDD RRG2_MOUSE 302 12 -
AFAEQLLPLEMDD RRD1_NOTVI 366 12 -
AFAEQLLPLEMDD RRD2_NOTVI 302 12 -
SFADQLLPLEMDD P79878 300 12 -
SFADQLLPLEMDD RRG1_XENLA 334 12 -
SFADQLLPLEMDD RRG2_XENLA 300 12 -
TFANQLLPLEMDD RRB2_HUMAN 304 12 -
TFANQLLPLEMDD RRB2_CHICK 304 12 -
TFANQLLPLEMDD RRB1_CHICK 311 12 -
TFANQLLPLEMDD RRB_MOUSE 338 12 -
AFANQLLPLEMDD Q90967 304 12 -
AFANQLLPLEMDD Q91155 305 12 -
AFANQLLPLEMDD Q90966 311 12 -
AFANQLLPLEMDD RRA_NOTVI 311 12 -
AFANQLLPLEMDD P97513 311 12 -
AFANQLLPLEMDD RRA_MOUSE 311 12 -
AFANQLLPLEMDD RRA1_HUMAN 311 12 -
AFANQLLPLEMDD Q15156 646 12 -
AFANQLLPLEMDD Q92019 300 12 -
AFAGQLLPLEMDD Q90968 302 12 -
AFANQLLPLEMDD Q90272 306 12 -
AFANQLLPLEMDD Q90271 298 12 -
AFANQPVPLEMDD RRA_XENLA 311 12 -

Motif 8 width=22
Element Seqn Id St Int Rpt
DLEEPEKVDKLQEPLLEALRLY RRG1_HUMAN 343 17 -
DLEEPEKVDKLQEPLLEALRLY RRG1_MOUSE 343 17 -
DLEEPEKVDKLQEPLLEALRLY RRG2_HUMAN 332 17 -
DLEEPEKVDKLQEPLLEALRLY RRG2_MOUSE 332 17 -
DLEEPEKVDKLQEPLLEALKIY RRD1_NOTVI 396 17 -
DLEEPEKVDKLQEPLLEALKIY RRD2_NOTVI 332 17 -
DLEEPEKVEKLQEPLLEALKFY P79878 330 17 -
DLEEPEKVEKLQEPLLEALKFY RRG1_XENLA 364 17 -
DLEEPEKVEKLQEPLLEGLKFY RRG2_XENLA 330 17 -
DLEEPTKVDKLQEPLLEALKIY RRB2_HUMAN 334 17 -
DLEEPMKVDKLQEPLLEALKIY RRB2_CHICK 334 17 -
DLEEPMKVDKLQEPLLEALKIY RRB1_CHICK 341 17 -
DLEEPTKVDKLQEPLLEALKIY RRB_MOUSE 368 17 -
DLEQPDKVDKLQEPLLEALKIY Q90967 334 17 -
DLEQPDKVDKLQEPLLEALKIY Q91155 335 17 -
DLEQPDKVDKLQEPLLEALKIY Q90966 341 17 -
DLEQPDKVDKLQEPLLEALKIY RRA_NOTVI 341 17 -
DLEQPDKVDMLQEPLLEALKVY P97513 341 17 -
DLEQPDKVDMLQEPLLEALKVY RRA_MOUSE 341 17 -
DLEQPDRVDMLQEPLLEALKVY RRA1_HUMAN 341 17 -
DLEQPDRVDMLQEPLLEALKVY Q15156 676 17 -
DLEQPDKVDKLQEPLLEALKIY Q92019 330 17 -
DLEEPEQVERLQEPLLEALRVY Q90968 332 17 -
DLEQSDKVDELQEPLLEALKIY Q90272 336 17 -
DLEQADKVDVLQEPLLEALKIY Q90271 328 17 -
DLEQPDKVDKLQEPLLEALKIY RRA_XENLA 341 17 -

Motif 9 width=16
Element Seqn Id St Int Rpt
RGISTKGAERAITLKM RRG1_HUMAN 387 22 -
RGISTKGAERAITLKM RRG1_MOUSE 387 22 -
RGISTKGAERAITLKM RRG2_HUMAN 376 22 -
RGISTKGAERAITLKM RRG2_MOUSE 376 22 -
RGISTKGAERAITLKM RRD1_NOTVI 440 22 -
RGISTKGAERAITLKM RRD2_NOTVI 376 22 -
RGISTKGAERAITLKL P79878 374 22 -
RGISTKGAERAITLKL RRG1_XENLA 408 22 -
RGISTKGAERAITLKL RRG2_XENLA 374 22 -
RSISAKGAERVITLKM RRB2_HUMAN 378 22 -
RSISAKGAERVITLKM RRB2_CHICK 378 22 -
RSISAKGAERVITLKM RRB1_CHICK 385 22 -
RSISAKGAERVITLKM RRB_MOUSE 412 22 -
RSISAKGAERVITLKM Q90967 378 22 -
RSISAKGAERVITLKM Q91155 379 22 -
RSISAKGAERVITLKM Q90966 385 22 -
RSISAKGAERVITLKM RRA_NOTVI 385 22 -
RSISAKGAERVITLKM P97513 385 22 -
RSISAKGAERVITLKM RRA_MOUSE 385 22 -
RSISAKGAERVITLKM RRA1_HUMAN 385 22 -
RSISAKGAERVITLKM Q15156 720 22 -
RSISAKGAERVITLKM Q92019 374 22 -
RGISTKGAERAITLKM Q90968 376 22 -
RSISAKGAERVITLKM Q90272 380 22 -
RSISAKGAELLITLKM Q90271 372 22 -
RTVSAKGAERVITLKM RRA_XENLA 385 22 -

Motif 10 width=14
Element Seqn Id St Int Rpt
PLIREMLENPEMFE RRG1_HUMAN 410 7 -
PLIREMLENPEMFE RRG1_MOUSE 410 7 -
PLIREMLENPEMFE RRG2_HUMAN 399 7 -
PLIREMLENPEMFE RRG2_MOUSE 399 7 -
PLIREMLENPEAFE RRD1_NOTVI 463 7 -
PLIREMLENPEAFE RRD2_NOTVI 399 7 -
PLIREMLENPEAFE P79878 397 7 -
PLIREMLENPEAFE RRG1_XENLA 431 7 -
PLIREMLENPEAFE RRG2_XENLA 397 7 -
PLIQEMLENSEGHE RRB2_HUMAN 401 7 -
PLIQEMLENSEGHE RRB2_CHICK 401 7 -
PLIQEMLENSEGHE RRB1_CHICK 408 7 -
PLIQEMLENSEGHE RRB_MOUSE 435 7 -
PLIQEMLENSEGMD Q90967 401 7 -
PLIQEMLENSEGLD Q91155 402 7 -
PLIQEMLENSEGMD Q90966 408 7 -
PLIQEMLENSEGLD RRA_NOTVI 408 7 -
PLIQEMLENSEGLD P97513 408 7 -
PLIQEMLENSEGLD RRA_MOUSE 408 7 -
PLIQEMLENSEGLD RRA1_HUMAN 408 7 -
PLIQEMLENSEGLD Q15156 743 7 -
PLIQEMLENSEGLD Q92019 397 7 -
PLIREMLENPEMFE Q90968 399 7 -
PLIQEMLENSEGLE Q90272 403 7 -
PLIQEMLENSEGLE Q90271 395 7 -
PLIQEMLENSEGLD RRA_XENLA 407 6 -