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PR01243

Identifier
NUCDPKINASE  [View Relations]  [View Alignment]  
Accession
PR01243
No. of Motifs
5
Creation Date
15-OCT-1999
Title
Nucleoside diphosphate kinase signature
Database References

PROSITE; PS00469 NDP_KINASES
PFAM; PF00334 NDK
INTERPRO; IPR001564
PDB; 1NDK; 1NDL; 1NSQ
SCOP; 1NDK; 1NDL; 1NSQ
CATH; 1NDK; 1NDL; 1NSQ
Literature References
1. GILLES, A.M., PRESECAN, E., VONICA, A. AND LASCU, I.
Nucleoside diphosphate kinase from human erythrocytes. Structural
characterization of the two polypeptide chains responsible for
heterogeneity of the hexameric enzyme. 
J.BIOL.CHEM. 266 8784-8789 (1991).
 
2. BIGGS, J., HERSPERGER, E., STEEG, P.S., LIOTTA, L.A. AND SHEARN, A.
A Drosophila gene that is homologous to a mammalian gene associated with
tumor metastasis codes for a nucleoside diphosphate kinase. 
CELL 63 933-940 (1990).
 
3. DUMAS, C., LASCU, I., MORERA, S., GLASER, P., FOURME, R., WALLET, V.,
LACOMBE, M.L., VERON, M. AND JANIN, J.
X-ray structure of nucleoside diphosphate kinase.
EMBO J. 11 3203-3208 (1992). 

Documentation
Nucleoside diphosphate kinase (NDK) is a required enzyme for synthesis of
nucleoside triphosphates (NTP) other than ATP. The enzyme acts via a
ping-pong mechanism in which a histidine residue is phosphorylated, by
transfer of the terminal phosphate group from ATP. In the presence of
magnesium, the phosphoenzyme can transfer its phosphate group to any NDP,
to produce an NTP. The enzyme thus furnishes NTPs for nucleic acid synthesis,
CTP for lipid synthesis, UTP for polysaccharide synthesis and GTP for
protein elongation, signal transduction and microtubule polymerisation.
 
In eukaryotes, NDK belongs to a family of isozymes, each of which acts in 
a different subcellular compartment and/or has a distinct biological
function. The isozymes form hexamers of related chains, designated A and B
[1]. Different associations of these chains (e.g., A6, A5B...AB5, B6)
result in isoenzymes with different isoelectric points.
 
NDK isozymes have been sequenced from both prokaryotic and eukaryotic 
sources. Drosophila abnormal wing disc protein has been shown to be a  
microtubule-associated NDK [2]. Mammalian NDK is also known as metastasis 
inhibition factor nm23. NDKs are highly conserved 17Kd proteins. Each
contains a single conserved histidine residue that participates in the
catalytic mechanism [2].
 
The X-ray structure of NDK from Dictyostelium discoideum has been determined
to 2.2A resolution [3]. The enzyme is a hexamer of identical subunits, with
a novel mononucleotide binding fold [3]. Each subunit contains an alpha/beta
domain with a four-stranded, anti-parallel beta-sheet. The topology differs
from that of adenylate kinase, but is identical to the allosteric domain of
Escherichia coli ATCase regulatory subunits, which bind mononucleotides at
an equivalent position [3]. Dimer contacts between NDK subunits within the 
hexamer are similar to those in ATCase. 
 
NUCDPKINASE is a 5-element fingerprint that provides a signature for 
nucleoside diphosphate kinases. The fingerprint was derived from an 
initial alignment of 11 sequences: the motifs were drawn from conserved
regions spanning the full alignment length - motif 1 spans the first beta-
strand and the first two alpha-helices; motif 2 spans helices 4 and 5; motif
3 encodes strand 3 and the N-terminal portion of helix 6; motif 4 spans
helices 7 and 8; and motif 5 spans strand 4 and helix 9. Two iterations on
SPTR37_10f were required to reach convergence, at which point a true set
comprising 62 sequences was identified. Several partial matches were also
found, all of which are related nucleoside diphosphate kinases that fail
to match one or more motifs.
Summary Information
  62 codes involving  5 elements
3 codes involving 4 elements
2 codes involving 3 elements
3 codes involving 2 elements
Composite Feature Index
56262626262
423313
321012
203003
12345
True Positives
NDK1_ARATH    NDK1_ORYSA    NDK1_PEA      NDK1_SACOF    
NDK1_SOYBN NDK1_SPIOL NDK2_ARATH NDK2_PEA
NDK2_SPIOL NDK3_HUMAN NDKA_BOVIN NDKA_DROME
NDKA_FLABI NDKA_HUMAN NDKA_MOUSE NDKA_RAT
NDKB_BOVIN NDKB_FLABI NDKB_HUMAN NDKB_MOUSE
NDKB_RAT NDKC_DICDI NDKM_DICDI NDKM_HUMAN
NDK_BACSU NDK_BRUMA NDK_COLLI NDK_ECOLI
NDK_HAEIN NDK_HELAN NDK_HELPY NDK_METJA
NDK_MYCTU NDK_MYXXA NDK_PSEAE NDK_RHOSU
NDK_SCHPO NDK_STAAU NDK_STRCO NDK_SYNP7
NDK_SYNY3 NDK_TREPA NDK_YEAST O26358
O29491 O42206 O49203 O57535
O57560 O58429 O65212 O81372
O84508 O85501 P70010 P70011
P70071 Q93576 Q9YI35 Q9Z7T5
Q9ZE91 Q9ZMN4
True Positive Partials
Codes involving 4 elements
NDK6_HUMAN NDK_AQUAE Q9ZFQ0
Codes involving 3 elements
O51419 P90666
Codes involving 2 elements
NDK5_HUMAN O75414 O88425
Sequence Titles
NDK1_ARATH  NUCLEOSIDE DIPHOSPHATE KINASE I (EC 2.7.4.6) (NDK I) (NDP KINASE I) - ARABIDOPSI 
NDK1_ORYSA NUCLEOSIDE DIPHOSPHATE KINASE I (EC 2.7.4.6) (NDK I) (NDP KINASE I) - ORYZA SATI
NDK1_PEA NUCLEOSIDE DIPHOSPHATE KINASE I (EC 2.7.4.6) (NDK I) (NDP KINASE I) (NDPK I) - P
NDK1_SACOF NUCLEOSIDE DIPHOSPHATE KINASE I (EC 2.7.4.6) (NDK I) (NDP KINASE I) (PP18) - SAC
NDK1_SOYBN NUCLEOSIDE DIPHOSPHATE KINASE I (EC 2.7.4.6) (NDK I) (NDP KINASE I) - GLYCINE MA
NDK1_SPIOL NUCLEOSIDE DIPHOSPHATE KINASE I (EC 2.7.4.6) (NDK I) (NDP KINASE I) - SPINACIA O
NDK2_ARATH NUCLEOSIDE DIPHOSPHATE KINASE II PRECURSOR (EC 2.7.4.6) (NDK II) (NDP KINASE II)
NDK2_PEA NUCLEOSIDE DIPHOSPHATE KINASE II PRECURSOR (EC 2.7.4.6) (NDK II) (NDP KINASE II)
NDK2_SPIOL NUCLEOSIDE DIPHOSPHATE KINASE II PRECURSOR (EC 2.7.4.6) (NDK II) (NDP KINASE II)
NDK3_HUMAN NUCLEOSIDE DIPHOSPHATE KINASE 3 (EC 2.7.4.6) (NDK 3) (NDP KINASE 3) (NM23-H4) (D
NDKA_BOVIN NUCLEOSIDE DIPHOSPHATE KINASE NBR-A (EC 2.7.4.6) (NDK NBR-A) (NDP KINASE NBR-A)
NDKA_DROME NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) (ABNORMAL WING DIS
NDKA_FLABI NUCLEOSIDE DIPHOSPHATE KINASE A (EC 2.7.4.6) (NDK A) (NDP KINASE A) - FLAVERIA B
NDKA_HUMAN NUCLEOSIDE DIPHOSPHATE KINASE A (EC 2.7.4.6) (NDK A) (NDP KINASE A) (TUMOR METAS
NDKA_MOUSE NUCLEOSIDE DIPHOSPHATE KINASE A (EC 2.7.4.6) (NDK A) (NDP KINASE A) (TUMOR METAS
NDKA_RAT NUCLEOSIDE DIPHOSPHATE KINASE A (EC 2.7.4.6) (NDK A) (NDP KINASE A) (TUMOR METAS
NDKB_BOVIN NUCLEOSIDE DIPHOSPHATE KINASE NBR-B (EC 2.7.4.6) (NDK NBR-B) (NDP KINASE NBR-B)
NDKB_FLABI NUCLEOSIDE DIPHOSPHATE KINASE B (EC 2.7.4.6) (NDK B) (NDP KINASE B) - FLAVERIA B
NDKB_HUMAN NUCLEOSIDE DIPHOSPHATE KINASE B (EC 2.7.4.6) (NDK B) (NDP KINASE B) (NM23-H2) (C
NDKB_MOUSE NUCLEOSIDE DIPHOSPHATE KINASE B (EC 2.7.4.6) (NDK B) (NDP KINASE B) (NM23-M2) (P
NDKB_RAT NUCLEOSIDE DIPHOSPHATE KINASE B (EC 2.7.4.6) (NDK B) (NDP KINASE B) (P18) - RATT
NDKC_DICDI NUCLEOSIDE DIPHOSPHATE KINASE, CYTOSOLIC (EC 2.7.4.6) (NDK) (NDP KINASE) - DICTY
NDKM_DICDI NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL PRECURSOR (EC 2.7.4.6) (NDK) (NDP K
NDKM_HUMAN NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL PRECURSOR (EC 2.7.4.6) (NDP KINASE,
NDK_BACSU NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - BACILLUS SUBTILI
NDK_BRUMA NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - BRUGIA MALAYI.
NDK_COLLI NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - COLUMBA LIVIA (D
NDK_ECOLI NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - ESCHERICHIA COLI
NDK_HAEIN NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - HAEMOPHILUS INFL
NDK_HELAN NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - HELIANTHUS ANNUU
NDK_HELPY NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - HELICOBACTER PYL
NDK_METJA NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - METHANOCOCCUS JA
NDK_MYCTU NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - MYCOBACTERIUM TU
NDK_MYXXA NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - MYXOCOCCUS XANTH
NDK_PSEAE NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - PSEUDOMONAS AERU
NDK_RHOSU NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - RHODOVULUM SULFI
NDK_SCHPO NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - SCHIZOSACCHAROMY
NDK_STAAU NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - STAPHYLOCOCCUS A
NDK_STRCO NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - STREPTOMYCES COE
NDK_SYNP7 NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - SYNECHOCOCCUS SP
NDK_SYNY3 NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - SYNECHOCYSTIS SP
NDK_TREPA NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - TREPONEMA PALLID
NDK_YEAST NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - SACCHAROMYCES CE
O26358 NUCLEOSIDE DIPHOSPHATE KINASE - METHANOBACTERIUM THERMOAUTOTROPHICUM.
O29491 NUCLEOSIDE DIPHOSPHATE KINASE (NDK) - ARCHAEOGLOBUS FULGIDUS.
O42206 NUCLEOSIDE DIPHOSPHATE KINASE - COLUMBA LIVIA (DOMESTIC PIGEON).
O49203 NUCLEOSIDE DIPHOSPHATE KINASE 3 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O57535 NUCLEOSIDE DIPHOSPHATE KINASE - GALLUS GALLUS (CHICKEN).
O57560 NUCLEOSIDE DIPHOSPHATE KINASE - SALMO SALAR (ATLANTIC SALMON).
O58429 160AA LONG HYPOTHETICAL NUCLEOSIDE-DIPHOSPHATE KINASE - PYROCOCCUS HORIKOSHII.
O65212 NUCLEOSIDE DIPHOSPHATE KINASE IA - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O81372 NUCLEOSIDE DIPHOSPHATE KINASE I (EC 2.7.4.6) - MESEMBRYANTHEMUM CRYSTALLINUM (CO
O84508 NUCLEOSIDE-2-P KINASE - CHLAMYDIA TRACHOMATIS.
O85501 NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) - MYCOBACTERIUM SMEGMATIS.
P70010 NM23/NUCLEOSIDE DIPHOSPHATE KINASE - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
P70011 NM23/NUCLEOSIDE DIPHOSPHATE KINASE - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
P70071 NM23/NUCLEOSIDE DIPHOSPHATE KINASE - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q93576 F25H2.5 PROTEIN - CAENORHABDITIS ELEGANS.
Q9YI35 NUCLEOSIDE DIPHOSPHATE KINASE - SCYLIORHINUS TORAZAME.
Q9Z7T5 NUCLEOSIDE-2-P KINASE - CHLAMYDIA PNEUMONIAE.
Q9ZE91 NUCLEOSIDE DIPHOSPHATE KINASE (NDK) - RICKETTSIA PROWAZEKII.
Q9ZMN4 NUCLEOSIDE DIPHOSPHATE KINASE - HELICOBACTER PYLORI J99.

NDK6_HUMAN PUTATIVE NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - HOMO SA
NDK_AQUAE NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6) (NDK) (NDP KINASE) - AQUIFEX AEOLICUS
Q9ZFQ0 NUCLEOSIDE DIPHOSPHATE KINASE - PSEUDOMONAS AERUGINOSA.

O51419 NUCLEOSIDE-DIPHOSPHATE KINASE (NDK) - BORRELIA BURGDORFERI (LYME DISEASE SPIROCH
P90666 INTERMEDIATE CHAIN 1 - ANTHOCIDARIS CRASSISPINA (SEA URCHIN).

NDK5_HUMAN NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5 (NDK-H 5) (NDP KINASE HOMOLOG 5) (NM23-H
O75414 TYPE 5 NUCLEOSIDE DIPHOSPHATE KINASE NM23-H5 (EC 2.7.4.6) - HOMO SAPIENS (HUMAN)
O88425 TYPE 5 NUCLEOSIDE DIPHOSPHATE KINASE NM23-M5 (EC 2.7.4.6) - MUS MUSCULUS (MOUSE)
Scan History
SPTR37_10f 2  100  NSINGLE    
Initial Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
TFIAIKPDGVQRGLVGEIIKRFE NDKA_RAT 7 7 -
TFIAIKPDGVQRGLVGEIIKRFE NDKA_HUMAN 7 7 -
TFIAIKPDGVQRGLVGEIIKRFE NDKB_HUMAN 7 7 -
TFIMIKPDGVQRGLVGEIIGRFE NDK_HELAN 4 4 -
TFIAIKPDGVQRGLVGEIIKRFE NDKA_MOUSE 7 7 -
TFIMIKPDGVQRGLIGEIISRFE NDK1_SOYBN 5 5 -
TFIMVKPDGVQRGLVGKIIERFE NDKA_DROME 8 8 -
TLSIIKPDGLEKGVIGKIISRFE NDK_MYXXA 5 5 -
TFVALKPDAVKRKLIGKIIERFE NDK_METJA 5 5 -
TLSIIKPDALKKKVVGKIIDRFE NDK_HELPY 5 5 -
TFSIIKPDATKRNLTGAINAKLE NDK_RHOSU 6 6 -

Motif 2 width=20
Element Seqn Id St Int Rpt
HYIDLKDRPFFSGLVKYMHS NDKA_RAT 51 21 -
HYVDLKDRPFFAGLVKYMHS NDKA_HUMAN 51 21 -
HYIDLKDRPFFPGLVKYMNS NDKB_HUMAN 51 21 -
HYADLSAKPFFNGLVEYIIS NDK_HELAN 48 21 -
HYTDLKDRPFFTGLVKYMHS NDKA_MOUSE 51 21 -
HYADLSAKPFFSGLVDYIIS NDK1_SOYBN 49 21 -
HYADLSARPFFPGLVNYMNS NDKA_DROME 52 21 -
FYAVHKARPFFKDLVQFMIS NDK_MYXXA 49 21 -
YYEEHKGKEFYERLINFMTS NDK_METJA 49 21 -
FYAIHRERPFFKDLIEFMVS NDK_HELPY 49 21 -
FYAVHKERPFYDELCEFMAS NDK_RHOSU 50 21 -

Motif 3 width=18
Element Seqn Id St Int Rpt
GPVVAMVWEGLNVVKTGR NDKA_RAT 71 0 -
GPVVAMVWEGLNVVKTGR NDKA_HUMAN 71 0 -
GPVVAMVWEGLNVVKTGR NDKB_HUMAN 71 0 -
GPVVAMVWEGKNVVTTGR NDK_HELAN 68 0 -
GPVVAMVWEGLNVVKTGR NDKA_MOUSE 71 0 -
GPVVAMIWEGKNVVTTGR NDK1_SOYBN 69 0 -
GPVVPMVWEGLNVVKTGR NDKA_DROME 72 0 -
GPVVLMVLEGENAVLANR NDK_MYXXA 69 0 -
GRMIVMVVEGENAISVVR NDK_METJA 69 0 -
GPVVVMVLEGKDAVAKNR NDK_HELPY 69 0 -
EPIVVQVLEGEDAIAKNR NDK_RHOSU 70 0 -

Motif 4 width=17
Element Seqn Id St Int Rpt
GETNPADSKPGTIRGDF NDKA_RAT 92 3 -
GETNPADSKPGTIRGDF NDKA_HUMAN 92 3 -
GETNPADSKPGTIRGDF NDKB_HUMAN 92 3 -
GATNPAESPPGTIRGDF NDK_HELAN 89 3 -
GETNPADSKPGTIRGDF NDKA_MOUSE 92 3 -
GATNPAQSEPGTIRGDF NDK1_SOYBN 90 3 -
GATNPADSLPGTIRGDF NDKA_DROME 93 3 -
GATNPAQAAEGTIRKDF NDK_MYXXA 90 3 -
GKTNPAEAEPGTIRGDF NDK_METJA 90 3 -
GATDPKLAQKGTIRADF NDK_HELPY 90 3 -
GATNPAEAAEGTIRKEF NDK_RHOSU 91 3 -

Motif 5 width=20
Element Seqn Id St Int Rpt
NIIHGSDSVESAEKEISLWF NDKA_RAT 115 6 -
NIIHGSDSVESAEKEIGLWF NDKA_HUMAN 115 6 -
NIIHGSDSVKSAEKEISLWF NDKB_HUMAN 115 6 -
NVIHGSDAVESAKKEIGLWF NDK_HELAN 112 6 -
NIIHGSDSVKSAEKEISLWF NDKA_MOUSE 115 6 -
NVIHGSDAVESANKEIALWF NDK1_SOYBN 113 6 -
NIIHGSDAVESAEKEIALWF NDKA_DROME 116 6 -
NTVHGSDSLENAKIEIAYFF NDK_MYXXA 113 6 -
NIIHASDSKESAEREIKLFF NDK_METJA 113 6 -
NAVHGSDSLENAHNEIAFFF NDK_HELPY 113 6 -
NSVHGSDAEDTAKEEIAYFF NDK_RHOSU 114 6 -
Final Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
TFIAIKPDGVQRGLVGEIIKRFE NDKB_RAT 7 7 -
TFIAIKPDGVQRGLIGEIIKRFE NDKA_BOVIN 6 6 -
TFIAIKPDGVQRGLVGEIIKRFE NDKB_MOUSE 7 7 -
TFIAIKPDGVQRGLVGEIIKRFE NDKA_RAT 7 7 -
TFIAIKPDGVQRGLMGEIIKRFE NDKB_BOVIN 6 6 -
TFIAIKPDGVQRGLVGEIIKRFE NDKA_HUMAN 7 7 -
TFIMIKPDGVQRGLVGEIIGRFE NDKB_FLABI 4 4 -
TFIAIKPDGVQRGLVGEIIKRFE NDKB_HUMAN 7 7 -
TFIAIKPDGVQRGLVGEIIKRFE O57535 8 8 -
TFIMIKPDGVQRGLVGEIIGRFE NDK_HELAN 4 4 -
TFIAIKPDGVQRGLVGEIIKRFE NDKA_MOUSE 7 7 -
TFIAIKPDGVQRRLVGDIIKRFE O57560 7 7 -
TFIAIKPDGVQRGLIGDIIKRFE P70071 8 8 -
TFIMIKPDGVQRGLVGEIISRFE O81372 4 4 -
TFIAIKPDGVQRGLVGEIIKRFE NDK_COLLI 8 8 -
TFIMIKPDGVQRGLVGEIISRFE NDK1_PEA 5 5 -
TFIAIKPDGVQRGLMGDIIKRFE P70010 8 8 -
TFIMIKPDGVQRGLIGEIISRFE NDK1_SOYBN 5 5 -
TFIMIKPDGVQRGLVGEIISRFE NDK1_SPIOL 4 4 -
TFIMIKPDGVQRGLIGEIISRFE NDK1_SACOF 4 4 -
TFIMVKPDGVQRGLVGKIIERFE NDKA_DROME 8 8 -
TFIMIKPDGVQSGLVGEIIGRFE NDKA_FLABI 4 4 -
TFIAIKPDGVQRGLMGDIIKRFE P70011 8 8 -
TFIMIKPDGVQRGLIGEVICRFE NDK1_ARATH 4 4 -
SFIMIKPDGVQRGLIGDIISRFE NDK1_ORYSA 4 4 -
TFIAIKPDGVHRGLVGKIIARFE Q93576 7 7 -
TFLAVKPDGVQRRLVGEIVRRFE NDK3_HUMAN 24 24 -
TFLAVKPDGVARGLVGEIIARYE NDKC_DICDI 11 11 -
TFIAIKPDGVQRGLVGTIIGRFE NDK_SYNP7 6 6 -
TFVMVKPDGVQRGLVGEVIGRLE O29491 4 4 -
TFICIKPDAVQRGLIGKIFERFE NDK_BRUMA 8 8 -
TFIMVKPDGVQRQLIGDILSRFE NDK_BACSU 5 5 -
TFIMIKPDGVQRQLIGEIVGRFE NDK_SYNY3 4 4 -
TFIAIKPDGVQRGLISEIISRFE O49203 91 91 -
TFIAVKPDAVQRGLIGYIISKFE NDK_SCHPO 6 6 -
AYIMVKPDGVQRGLVGEIISRFE NDK2_PEA 85 85 -
TFIAVKPDGVQRGLVSQILSRFE NDK_YEAST 8 8 -
TLVAVKPDGVQRRLVGDVIQRFE NDKM_HUMAN 40 40 -
TLIAVKSDGVQRGLIGEIIKRFE Q9YI35 4 4 -
TYIMVKPDGIQRGLVGEIISRFE O65212 7 7 -
TYIMIKPDGVQRGLVGEIISRFE NDK2_SPIOL 88 88 -
SFIAIKWNSTQRRLIGEIIARFE NDKM_DICDI 75 75 -
TYIMVKPDGIQRGLVGEIISRFE NDK2_ARATH 86 86 -
TLVIIKPDAVVRGLIGEIISRFE O58429 10 10 -
SFVMLKPDAVKRRLAGRIIARFE O26358 5 5 -
TFLMIKPDAVQRNLIGEVISRIE NDK_STAAU 4 4 -
TLSIIKPDGLEKGVIGKIISRFE NDK_MYXXA 5 5 -
TLVLVKPDAVQRRLVGNVIQRFE O42206 35 35 -
TLVLIKPDGIERQLIGEIISRIE NDK_MYCTU 5 5 -
TLVLIKPDGVKRQLVGEILSRIE O85501 5 5 -
TFVALKPDAVKRKLIGKIIERFE NDK_METJA 5 5 -
SLVLLKPDAVRRGLTGEIISRIE NDK_STRCO 5 5 -
TLSIIKPDALKKKVVGKIIDRFE NDK_HELPY 5 5 -
TLSIIKPDALKKKVVGKIIDRFE Q9ZMN4 5 5 -
TLSIIKPDAVSKNVIGEILTRFE NDK_PSEAE 6 6 -
TFSIIKPNAVAKNVIGNIFARFE NDK_ECOLI 5 5 -
TFSIIKPDVVKRNLIGAILTRFE NDK_HAEIN 6 6 -
TLSIIKPDSVSKAHIGEILSIFE Q9Z7T5 4 4 -
TFVMLKPGVLQRRLVGEVLSRFE NDK_TREPA 6 6 -
TLSIIKPDSVGKAHIGEIIAIFE O84508 4 4 -
TFSMIKPDVIKRNKIGQVNTYLE Q9ZE91 6 6 -
TFSIIKPDATKRNLTGAINAKLE NDK_RHOSU 6 6 -

Motif 2 width=20
Element Seqn Id St Int Rpt
HYIDLKDRPFFPGLVKYMNS NDKB_RAT 51 21 -
HYIDLKDRPFFAGLVKYMHS NDKA_BOVIN 50 21 -
HYIDLKDRPFFPGLVKYMNS NDKB_MOUSE 51 21 -
HYIDLKDRPFFSGLVKYMHS NDKA_RAT 51 21 -
HYIDLKDRPFFAGLVKYMHS NDKB_BOVIN 50 21 -
HYVDLKDRPFFAGLVKYMHS NDKA_HUMAN 51 21 -
HYADLSAKPFFNGLVEYIIS NDKB_FLABI 48 21 -
HYIDLKDRPFFPGLVKYMNS NDKB_HUMAN 51 21 -
HYIDLKDRPFYPGLVKYMNS O57535 52 21 -
HYADLSAKPFFNGLVEYIIS NDK_HELAN 48 21 -
HYTDLKDRPFFTGLVKYMHS NDKA_MOUSE 51 21 -
HYADLKDRPFFPGLVSYMTS O57560 51 21 -
HYIDLKDRPFYPGLVEYMSS P70071 52 21 -
HYADLSAKPFFNGLVEYIVS O81372 48 21 -
HYIDLKDRPFYPGLVKYMNS NDK_COLLI 52 21 -
HYADLSAKPFFSGLVDYIIS NDK1_PEA 49 21 -
HYIDLKDRPFYPGLVEYMSS P70010 52 21 -
HYADLSAKPFFSGLVDYIIS NDK1_SOYBN 49 21 -
HYADLSAKPFFNGLVEYIVS NDK1_SPIOL 48 21 -
HYADLSSKPFFQGLVDYIIS NDK1_SACOF 48 21 -
HYADLSARPFFPGLVNYMNS NDKA_DROME 52 21 -
HYADLSSKPFFNGLVEYIVS NDKA_FLABI 48 21 -
HYIDLKDRPFYPGLVEYMNS P70011 52 21 -
HYEDLSSKSFFSGLVDYIVS NDK1_ARATH 48 21 -
HYADLSDKPFFPGLVEYIIS NDK1_ORYSA 48 21 -
HYQDLKDKPFFPSLIEYMSS Q93576 51 21 -
HYAELRERPFYGRLVKYMAS NDK3_HUMAN 68 21 -
HYAEHKERPFFGGLVSFITS NDKC_DICDI 55 21 -
HYAVHRERPFFNGLVEFITS NDK_SYNP7 50 21 -
HYAEHREKPFFSALVDYITS O29491 48 21 -
HYQELQGKPFFNDLVGYMSS NDK_BRUMA 52 21 -
HYAEHQGKPFFGELVEFITS NDK_BACSU 49 21 -
HYEALNDKPFFSGLVNFICS NDK_SYNY3 48 21 -
HYHDLKERPFFNGLCDFLSS O49203 135 21 -
HYAEHKGKPFYEKLVGFMAS NDK_SCHPO 50 21 -
HYKHLNQKSFFPKLIEYITS NDK2_PEA 129 21 -
HYAEHVGKPFFPKMVSFMKS NDK_YEAST 52 21 -
HYQDLRRKPFYPALIRYMSS NDKM_HUMAN 84 21 -
HYIDLKDKPFYAGLCKFTSA Q9YI35 48 21 -
HYKDLSAKSFFPNLIEYITS O65212 51 21 -
HYKDLKAKSFYQKLIDYITS NDK2_SPIOL 132 21 -
HYEDLNKKPFFNGLVKFFSS NDKM_DICDI 119 21 -
HYKELSAKSFFLTLIEYITS NDK2_ARATH 130 21 -
HYEEHREKPFFKALIDYITK O58429 54 21 -
HYQEHREKPFFRDLVDYITS O26358 49 21 -
HYGEHQGKPFYNDLISFITS NDK_STAAU 48 21 -
FYAVHKARPFFKDLVQFMIS NDK_MYXXA 49 21 -
HYQQLRQKPFYPALLAYMTS O42206 79 21 -
HYAEHEGKPFFGSLLEFITS NDK_MYCTU 49 21 -
HYAEHADKPFFGSLLEFITS O85501 49 21 -
YYEEHKGKEFYERLINFMTS NDK_METJA 49 21 -
HYGEHKGKPFYEPLVEFMAS NDK_STRCO 50 22 -
FYAIHRERPFFKDLIEFMVS NDK_HELPY 49 21 -
FYAIHRERPFFKDLIEFMVS Q9ZMN4 49 21 -
FYAEHKARPFFKDLVSFMTS NDK_PSEAE 50 21 -
FYAEHDGKPFFDGLVEFMTS NDK_ECOLI 49 21 -
FYAEHQGKEFFVPLVEYMMS NDK_HAEIN 50 21 -
FYFVHRERPFFQELVDFMVS Q9Z7T5 48 21 -
HYAEHREKPFYPSLIAYITS NDK_TREPA 50 21 -
FYVVHKERPFFQELVDFMIS O84508 48 21 -
FYDEHRARSFFNSLVEYITS Q9ZE91 50 21 -
FYAVHKERPFYDELCEFMAS NDK_RHOSU 50 21 -

Motif 3 width=18
Element Seqn Id St Int Rpt
GPVVAMVWEGLNVVKTGR NDKB_RAT 71 0 -
GPVVAMVWEGLNVVKTGR NDKA_BOVIN 70 0 -
GPVVAMVWEGLNVVKTGR NDKB_MOUSE 71 0 -
GPVVAMVWEGLNVVKTGR NDKA_RAT 71 0 -
GPVVAMVWEGLNVVKTGR NDKB_BOVIN 70 0 -
GPVVAMVWEGLNVVKTGR NDKA_HUMAN 71 0 -
GPVVAMVWEGKNVVTTGR NDKB_FLABI 68 0 -
GPVVAMVWEGLNVVKTGR NDKB_HUMAN 71 0 -
GPVVAMVWEGLNVVKTGR O57535 72 0 -
GPVVAMVWEGKNVVTTGR NDK_HELAN 68 0 -
GPVVAMVWEGLNVVKTGR NDKA_MOUSE 71 0 -
GPVVAMVWEGFNVVKTGR O57560 71 0 -
GPVLAMVWEGLNVVKTGR P70071 72 0 -
GPVVAMVWEGKGVVLTGR O81372 68 0 -
GPIVAMVWEGLNVVKTGR NDK_COLLI 72 0 -
GPVVAMIWEGKNVVTTGR NDK1_PEA 69 0 -
GPVLAMVWEGLNVVKTGR P70010 72 0 -
GPVVAMIWEGKNVVTTGR NDK1_SOYBN 69 0 -
GPVVAMVWEGKGVVATGR NDK1_SPIOL 68 0 -
GPVVAMVWEGKSVVTTGR NDK1_SACOF 68 0 -
GPVVPMVWEGLNVVKTGR NDKA_DROME 72 0 -
GPVVAMVWEGKNVVTTGR NDKA_FLABI 68 0 -
GPVLAMVWEGLNVVKTGR P70011 72 0 -
GPVVAMIWEGKNVVLTGR NDK1_ARATH 68 0 -
GPVVAMVWEGKDVVATGR NDK1_ORYSA 68 0 -
GPVVAMVWQGLDVVKQGR Q93576 71 0 -
GPVVAMVWQGLDVVRTSR NDK3_HUMAN 88 0 -
GPVVAMVFEGKGVVASAR NDKC_DICDI 75 0 -
GPIVAIVLEGEGVVAAAR NDK_SYNP7 70 0 -
GPVVAMVVEGKNAIKVVR O29491 68 0 -
GPVIAMVWEGLDVVKQAR NDK_BRUMA 72 0 -
GPVFAMVWEGENVIEVTR NDK_BACSU 69 0 -
SPVVAMVWEGNSIVSTSR NDK_SYNY3 68 0 -
GPVIAMVWEGDGVIRYGR O49203 155 0 -
GPVCAMIWEGKQAVKTGR NDK_SCHPO 70 0 -
GPVVSMAWEGVGVVPSAR NDK2_PEA 149 0 -
GPILATVWEGKDVVRQGR NDK_YEAST 72 0 -
GPVVAMVWEGYNVVRASR NDKM_HUMAN 104 0 -
GPFVAMCWEGQNIVKMGR Q9YI35 68 0 -
GPVVCMAWEGVGVVASAR O65212 71 0 -
GPVVCMAWEGVGVVASSR NDK2_SPIOL 152 0 -
GAVVAMVFEGKDVVRTGR NDKM_DICDI 139 0 -
GPVVCMAWEGVGVVASAR NDK2_ARATH 150 0 -
TPVVVMVLEGRYAVEVVR O58429 74 0 -
APVIAMVIEGKDCISLIR O26358 69 0 -
APVFAMVVEGEDAVNVSR NDK_STAAU 68 0 -
GPVVLMVLEGENAVLANR NDK_MYXXA 69 0 -
GPLVAMVWEGYNVVRSTR O42206 99 0 -
GPVVAAIVEGTRAIAAVR NDK_MYCTU 69 0 -
GPLVAAIVEGPRAVAAFR O85501 69 0 -
GRMIVMVVEGENAISVVR NDK_METJA 69 0 -
GPVVAMVVEGERVIEGVR NDK_STRCO 70 0 -
GPVVVMVLEGKDAVAKNR NDK_HELPY 69 0 -
GPVVVMVLEGKDAVAKNR Q9ZMN4 69 0 -
GPVVVQVLEGEDAIAKNR NDK_PSEAE 70 0 -
GPIVVSVLEGENAVQRHR NDK_ECOLI 69 0 -
SPIVVSVLEKENAVKDYR NDK_HAEIN 70 0 -
GPVVVLVLEGANAVSRNR Q9Z7T5 68 0 -
APVVALAFKGENAISLVR NDK_TREPA 70 0 -
GPVVVMVLQGENAVDRNR O84508 68 0 -
GAVVLQVLKGEDAITLNR Q9ZE91 70 0 -
EPIVVQVLEGEDAIAKNR NDK_RHOSU 70 0 -

Motif 4 width=17
Element Seqn Id St Int Rpt
GETNPADSKPGTIRGDF NDKB_RAT 92 3 -
GETNPADSKPGTIRGDF NDKA_BOVIN 91 3 -
GETNPADSKPGTIRGDF NDKB_MOUSE 92 3 -
GETNPADSKPGTIRGDF NDKA_RAT 92 3 -
GETNPADSKPGTIRGDF NDKB_BOVIN 91 3 -
GETNPADSKPGTIRGDF NDKA_HUMAN 92 3 -
GATNPAESAPGTIRGDF NDKB_FLABI 89 3 -
GETNPADSKPGTIRGDF NDKB_HUMAN 92 3 -
GETNPADSKPGTIRGDF O57535 93 3 -
GATNPAESPPGTIRGDF NDK_HELAN 89 3 -
GETNPADSKPGTIRGDF NDKA_MOUSE 92 3 -
GETNPADSKPGTIRGDF O57560 92 3 -
GETNPADSKPGTIRGDF P70071 93 3 -
GATNPLASEPGTIRGDF O81372 89 3 -
GETNPADSKPGTIRGDF NDK_COLLI 93 3 -
GATNPAQSEPGTIRGDF NDK1_PEA 90 3 -
GETNPADSKPGTIRGDF P70010 93 3 -
GATNPAQSEPGTIRGDF NDK1_SOYBN 90 3 -
GATNPLASEPGTIRGDF NDK1_SPIOL 89 3 -
GATNPLVSEPGTIRGDF NDK1_SACOF 89 3 -
GATNPADSLPGTIRGDF NDKA_DROME 93 3 -
GATNPAESAPGTIRGDF NDKA_FLABI 89 3 -
GETNPADSKPGTIRGDL P70011 93 3 -
GATNPAASEPGTIRGDF NDK1_ARATH 89 3 -
GATRPWEAAPGTIRADY NDK1_ORYSA 89 3 -
GATNPLASAPGTIRGDF Q93576 92 3 -
GATNPADAPPGTIRGDF NDK3_HUMAN 109 3 -
GVTNPLASAPGSIRGDF NDKC_DICDI 96 3 -
GATNPLTAEPGTIRGDF NDK_SYNP7 91 3 -
GATNPAEAAPGTIRGDF O29491 89 3 -
GATNPLNSMPGTIRGDF NDK_BRUMA 93 3 -
GKTNPKEALPGTIRGDY NDK_BACSU 90 3 -
GATDPHAAAPGTIRGDY NDK_SYNY3 89 3 -
GATDPQKSEPGTIRGDL O49203 176 3 -
GASNPLDSAPGTIRGDY NDK_SCHPO 91 3 -
GATDPLQAEPGTIRGDF NDK2_PEA 170 3 -
GATNPLGSAPGTIRGDF NDK_YEAST 93 3 -
GHTDSAEAAPGTIRGDF NDKM_HUMAN 125 3 -
GETNPADSKPGTIRGDL Q9YI35 89 3 -
GKTDPLQAEPGTIRGDL O65212 92 3 -
GATDPLQAEPGTIRGDL NDK2_SPIOL 173 3 -
GATVPSQSAPGTIRFDL NDKM_DICDI 160 3 -
GKTDPLQAEPGTIRGDL NDK2_ARATH 171 3 -
GATDPKDAAPGTIRGDF O58429 95 3 -
GATNPAEADLGTIRGDF O26358 90 3 -
GSTNPSEASPGSIRGDL NDK_STAAU 89 3 -
GATNPAQAAEGTIRKDF NDK_MYXXA 90 3 -
GDTDSAVAAAGTIRGDF O42206 120 3 -
GTDPVQAAAPGTIRGDF NDK_MYCTU 91 4 -
GTDPVEKAVPGTIRGDF O85501 91 4 -
GKTNPAEAEPGTIRGDF NDK_METJA 90 3 -
GPTDPIAAAPGSIRGDY NDK_STRCO 91 3 -
GATDPKLAQKGTIRADF NDK_HELPY 90 3 -
GATDPKLAQKGTIRADF Q9ZMN4 90 3 -
GATDPKKADAGTIRADF NDK_PSEAE 91 3 -
GATNPANALAGTLRADY NDK_ECOLI 90 3 -
GTTNPETAAEGTIRKDF NDK_HAEIN 91 3 -
GATNPAEAASGTIRAKF Q9Z7T5 89 3 -
GSTRVEHAQPGTIRGDF NDK_TREPA 91 3 -
GATNPKEAAEGSIRALF O84508 89 3 -
GATNPAEAKEGTIRKDL Q9ZE91 91 3 -
GATNPAEAAEGTIRKEF NDK_RHOSU 91 3 -

Motif 5 width=20
Element Seqn Id St Int Rpt
NIIHGSDSVESAEKEIGLWF NDKB_RAT 115 6 -
NIIHGSDSVESAEKEIALWF NDKA_BOVIN 114 6 -
NIIHGSDSVESAEKEIHLWF NDKB_MOUSE 115 6 -
NIIHGSDSVESAEKEISLWF NDKA_RAT 115 6 -
NIIHGSDSVESAEKEIALWF NDKB_BOVIN 114 6 -
NIIHGSDSVESAEKEIGLWF NDKA_HUMAN 115 6 -
NVIHGSDAVESAKKEIALWF NDKB_FLABI 112 6 -
NIIHGSDSVKSAEKEISLWF NDKB_HUMAN 115 6 -
NIIHGSDSVESAQKEISLWF O57535 116 6 -
NVIHGSDAVESAKKEIGLWF NDK_HELAN 112 6 -
NIIHGSDSVKSAEKEISLWF NDKA_MOUSE 115 6 -
NIIHGSDSVESANTEINLWF O57560 115 6 -
NIIHGSDSVESANKEIALWF P70071 116 6 -
NVIHGSDAVESATKEIALWF O81372 112 6 -
NIIHGSDSVESAQKEINLWF NDK_COLLI 116 6 -
NVIHGSDAVESANKEIALWF NDK1_PEA 113 6 -
NIIHGSDSVESANKEIALWF P70010 116 6 -
NVIHGSDAVESANKEIALWF NDK1_SOYBN 113 6 -
NVIHGSDAVDSATKEIALWF NDK1_SPIOL 112 6 -
NVIHGSDSIESANKEIALWF NDK1_SACOF 112 6 -
NIIHGSDAVESAEKEIALWF NDKA_DROME 116 6 -
NVIHGSDAVESARKVIGLWF NDKA_FLABI 112 6 -
NIIHGSDSVDSANKEIALWF P70011 116 6 -
NVIHGSDSVESARKEIALWF NDK1_ARATH 112 6 -
NVIHGSDSVDNGKKEIALWF NDK1_ORYSA 112 6 -
NICHGSDAVDSANREIAHWF Q93576 115 6 -
NLIHGSDSVESARREIALWF NDK3_HUMAN 131 5 -
NIIHGSDSVESANREIALWF NDKC_DICDI 119 6 -
NIIHGSDAIETAQQEIALWF NDK_SYNP7 114 6 -
NVVHASDSPQSAEREISLFF O29491 112 6 -
NIVHGSDSLPSAEREITHWF NDK_BRUMA 116 6 -
NIIHGSDSLESAEREINIFF NDK_BACSU 113 6 -
NIIHGSDAIETAKREISLWF NDK_SYNY3 112 6 -
NIIHGSDGPETAKDEISLWF O49203 199 6 -
NVCHGSDSIESANREIKLWF NDK_SCHPO 114 6 -
NIIHGSDSPENGEREIALWF NDK2_PEA 193 6 -
NVCHGSDSVDSAEREINLWF NDK_YEAST 116 6 -
NVIHASDSVEGAQREIQLWF NDKM_HUMAN 148 6 -
NIIHGSDSLETAKKEVALWF Q9YI35 112 6 -
NIVHGSDSPENGKREIGLWF O65212 115 6 -
NVVHGSDSPDNGKREIGLWF NDK2_SPIOL 196 6 -
NIIHGSDSNESAAHEIALWF NDKM_DICDI 183 6 -
NIVHGSDSPENGKREIGLWF NDK2_ARATH 194 6 -
NVIHASDSKESAEREISLFF O58429 121 9 -
NIIHASDSPESAEREIKLFF O26358 113 6 -
NIIHGSDSLESAEREINLWF NDK_STAAU 112 6 -
NTVHGSDSLENAKIEIAYFF NDK_MYXXA 113 6 -
NVVHASDSVETAQREIGFWF O42206 143 6 -
NLVHGSDSAESAQREIALWF NDK_MYCTU 114 6 -
NLVHGSDSPESAAREIALWF O85501 114 6 -
NIIHASDSKESAEREIKLFF NDK_METJA 113 6 -
NLIHASDSEESAERELKIFF NDK_STRCO 114 6 -
NAVHGSDSLENAHNEIAFFF NDK_HELPY 113 6 -
NAVHGSDSLENAHNEIAFFF Q9ZMN4 113 6 -
NAVHGSDSEASAAREIVYFF NDK_PSEAE 114 6 -
NGTHGSDSVESAAREIAYFF NDK_ECOLI 113 6 -
NSVHGSDSIESANREIAYFF NDK_HAEIN 114 6 -
NAVHGSDTLENAAVEIAYFF Q9Z7T5 112 6 -
NIVHASDSPESAARELALYF NDK_TREPA 114 6 -
NAVHGSDSLENAAIEVSYFF O84508 112 6 -
NSIHGSDSENSAKREIKFFF Q9ZE91 114 6 -
NSVHGSDAEDTAKEEIAYFF NDK_RHOSU 114 6 -