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PR01047

Identifier
TRNASYNTHTHR  [View Relations]  [View Alignment]  
Accession
PR01047
No. of Motifs
5
Creation Date
21-DEC-1998  (UPDATE 07-JUN-1999)
Title
Threonyl-tRNA synthetase signature
Database References
PRINTS; PR90000 TRNASYNTH; PR90002 TRNASYNTHCLII
PROSITE; PS00179 AA_TRNA_LIGASE_II_1; PS00339 AA_TRNA_LIGASE_II_2
INTERPRO; IPR002320
Literature References
1. LODISH, H., BALTIMORE, D., BERK, A., ZIPURSKY, S.L., MATSUDAIRA, P.
AND DARNELL, J.
Nucleic Acids, the Genetic Code, and Protein Synthesis. 
IN MOLECULAR CELL BIOLOGY, SCIENTIFIC AMERICAN BOOKS (NEW YORK), 1995,
PP.126-128.
 
2. DELARUE, M.
Aminoacyl-tRNA synthetases.
CURR.OPIN.STRUCT.BIOL. 5 48-55 (1995).
 
3. PERONA, J.J., ROULD, M. AND STEITZ, T.A.
Structural Basis for Transfer RNA Aminoacylation by Escherichia coli
Glutaminyl-tRNA Synthetase.
BIOCHEMISTRY 32 8758-8771 (1993).

Documentation
Appropriate attachment of an amino acid to its cognate tRNA is the key to
faithful translation of the genetic code. The family of enzymes responsible
for this is the aminoacyl-tRNA synthetases (AATRSs) (EC 6.1.1.-).
     
AATRSs catalyse a two-step reaction:
    
(1) Enzyme + amino acid + ATP ---> Enzyme(aminoacyl-AMP) + PPi
    
(2) tRNA + Enzyme(aminoacyl-AMP) ---> aminoacyl-tRNA + AMP + Enzyme
 
In the first step, they form an aminoacyl-adenylate, in which the carboxyl
of the amino acid is linked to the alpha-phosphate of ATP, by displacing
the pyrophosphate. When the correct tRNA is bound, the aminoacyl group is
transferred to the 2'- or 3'-terminal OH of the tRNA at the expense of AMP
[1].
 
Based on structural and sequence comparisons, this group of at least 20
proteins (in prokaryotes there are approximately 20, but in eukaryotes
there are usually 2 forms for each amino acid; namely, the cytosolic and
mitochondrial forms) can be divided into two classes.
 
Class I AATRSs contain a characteristic Rossman fold and are mostly
monomeric. At the primary structure level, two highly-conserved motifs
are observed, `HIGH' and `KMSKS' [2,3]; these are associated with the ATP-
binding site.
 
Class II AATRSs share an anti-parallel beta-sheet formation, flanked by
alpha-helices [3], and are mostly dimeric or multimeric.
 
Further distinction between the two classes is evident when the reaction
mechanisms are investigated. In reactions catalysed by the class I AATRSs,
the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in
class II reactions, the 3'-hydroxyl site is preferred.
 
Threonyl-tRNA synthetase (EC 6.1.1.3) is specific to threonine and belongs
to class II.
 
TRNASYNTHTHR is a 5-element fingerprint that provides a signature for the
threonyl-tRNA synthetase. The fingerprint was derived from an initial
alignment of 13 sequences: the motifs were drawn from conserved regions
spanning the C-terminal portion of the alignment - motifs 2 and 4 include
the regions encoded by PROSITE patterns AA_TRNA_LIGASE_II_1 (PS00179) and 
AA_TRNA_LIGASE_II_2 (PS00339) respectively. Two iterations on OWL31.1 were
required to reach convergence, at which point a true set comprising 29 
sequences was identified. Several partial matches were also found: SYT_PSESY
is a threonyl-tRNA synthetase fragment lacking motifs 1 and 2; and F71359 
and A70150 are prolyl tRNA-synthetases.
 
An update on SPTR37_9f identified a true set of 28 sequences.
Summary Information
28 codes involving  5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
52828282828
400000
300000
200000
12345
True Positives
O51662        O58430        O67583        O81907        
O84585 SYT1_BACSU SYT2_BACSU SYTC_ARATH
SYTC_CAEEL SYTC_HUMAN SYTC_SCHPO SYTC_YEAST
SYTM_SCHPO SYTM_YEAST SYT_ARCFU SYT_BUCAP
SYT_ECOLI SYT_HAEIN SYT_HELPY SYT_METJA
SYT_METTH SYT_MYCGE SYT_MYCLE SYT_MYCPN
SYT_MYCTU SYT_RICPR SYT_SYNY3 SYT_TREPA
Sequence Titles
O51662      THREONYL-TRNA SYNTHETASE (THRZ) - BORRELIA BURGDORFERI (LYME DISEASE SPIROCHETE). 
O58430 625AA LONG HYPOTHETICAL THREONYL-TRNA SYNTHETASE - PYROCOCCUS HORIKOSHII.
O67583 THREONYL-TRNA SYNTHETASE - AQUIFEX AEOLICUS.
O81907 THREONYL-TRNA SYNTHETASE (EC 6.1.1.3) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O84585 THREONYL TRNA SYNTHETASE - CHLAMYDIA TRACHOMATIS.
SYT1_BACSU THREONYL-TRNA SYNTHETASE 1 (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - BACILLUS SUBTILIS.
SYT2_BACSU THREONYL-TRNA SYNTHETASE 2 (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - BACILLUS SUBTILIS.
SYTC_ARATH PROBABLE THREONYL-TRNA SYNTHETASE, CYTOPLASMIC (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
SYTC_CAEEL PROBABLE THREONYL-TRNA SYNTHETASE, CYTOPLASMIC (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - CAENORHABDITIS ELEGANS.
SYTC_HUMAN THREONYL-TRNA SYNTHETASE, CYTOPLASMIC (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - HOMO SAPIENS (HUMAN).
SYTC_SCHPO THREONYL-TRNA SYNTHETASE, CYTOPLASMIC (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
SYTC_YEAST THREONYL-TRNA SYNTHETASE, CYTOPLASMIC (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
SYTM_SCHPO PROBABLE THREONYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
SYTM_YEAST THREONYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
SYT_ARCFU THREONYL-TRNA SYNTHETASE (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - ARCHAEOGLOBUS FULGIDUS.
SYT_BUCAP THREONYL-TRNA SYNTHETASE (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - BUCHNERA APHIDICOLA.
SYT_ECOLI THREONYL-TRNA SYNTHETASE (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - ESCHERICHIA COLI.
SYT_HAEIN THREONYL-TRNA SYNTHETASE (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - HAEMOPHILUS INFLUENZAE.
SYT_HELPY THREONYL-TRNA SYNTHETASE (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
SYT_METJA THREONYL-TRNA SYNTHETASE (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - METHANOCOCCUS JANNASCHII.
SYT_METTH THREONYL-TRNA SYNTHETASE (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - METHANOBACTERIUM THERMOAUTOTROPHICUM.
SYT_MYCGE THREONYL-TRNA SYNTHETASE (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - MYCOPLASMA GENITALIUM.
SYT_MYCLE THREONYL-TRNA SYNTHETASE (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - MYCOBACTERIUM LEPRAE.
SYT_MYCPN THREONYL-TRNA SYNTHETASE (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - MYCOPLASMA PNEUMONIAE.
SYT_MYCTU THREONYL-TRNA SYNTHETASE (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - MYCOBACTERIUM TUBERCULOSIS.
SYT_RICPR THREONYL-TRNA SYNTHETASE (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - RICKETTSIA PROWAZEKII.
SYT_SYNY3 THREONYL-TRNA SYNTHETASE (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
SYT_TREPA THREONYL-TRNA SYNTHETASE (EC 6.1.1.3) (THREONINE--TRNA LIGASE) (THRRS) - TREPONEMA PALLIDUM.
Scan History
OWL31_1    2  100  NSINGLE    
SPTR37_9f 2 31 NSINGLE
Initial Motifs
Motif 1  width=29
Element Seqn Id St Int Rpt
LKPMNCPGHCLMFKSRERSYRELPWRVAD SYTC_YEAST 415 415 -
LKPMNCPGHSLMFDHRPRSWRELPLRLAD SYTC_HUMAN 396 396 -
LKPMNCPMHCLIFRARGRSYRELPLRLFE SYT_MYCTU 369 369 -
LKPMNCPGHCLIFQHRVRSYRELPMRLAD SYTC_ARATH 382 382 -
IKPMNCPGHVQIFNQGLKSYRDLPLRMAE SYT_ECOLI 329 329 -
IKPMNCPGHVQIFNQGLKSYRDLPIRMAE SYT_HAEIN 329 329 -
IKPMNCPGHVQIFNCGLKSYRDLPIRMAE SYT_BUCAP 329 329 -
LKPMNCPGHCLIFGKKDRSYNELPLRFSD SYTM_YEAST 128 128 -
LKPMNCPCHVQIFKQGIKSYRDLPLRMSE SYT_RICPR 328 328 -
LKPMNCPFHIQIYKSELRSYRDLPLRLAE SYT_SYNY3 291 291 -
IKPMNCVGHIKVYQSALHSYRDLPLRFYE SYT_HELPY 305 305 -
LRFAACFGQFLMLSSSTITYRNLPLKIYE SYT_ARCFU 283 283 -
LRYACCFGAFRILSDSFLTWKNLPASIYE SYT_METTH 280 280 -

Motif 2 width=24
Element Seqn Id St Int Rpt
HRNEFSGALSGLTRVRRFQQDDAH SYTC_YEAST 448 4 -
HRNELSGALTGLTRVRRFQQDDAH SYTC_HUMAN 429 4 -
YRYEKSGVVHGLTRVRGLTMDDAH SYT_MYCTU 402 4 -
HRNEASGALSGLTRVRRFQQDDAH SYTC_ARATH 415 4 -
HRNEPSGSLHGLMRVRGFTQDDAH SYT_ECOLI 362 4 -
HRNEPSGSLHGLMRVRGFTQDDAH SYT_HAEIN 362 4 -
HRNESSGSLHGLMRIRNFTQDDAH SYT_BUCAP 362 4 -
HRNEASGALSGLTRLRKFHQDDGH SYTM_YEAST 161 4 -
HRNEASGALHGLMRVRSLVQDDAH SYT_RICPR 361 4 -
YRYEQSGELGGLTRVRGFTVDDSH SYT_SYNY3 324 4 -
HRHEKSGVLHGLLRVREFTQDDAH SYT_HELPY 338 4 -
FRKEQRGELVGLRRLRAFTMPDMH SYT_ARCFU 317 5 -
FRLEKKGEVVGLKRLRGFTMPDLH SYT_METTH 314 5 -

Motif 3 width=29
Element Seqn Id St Int Rpt
PKIDIMISDALRRWHQCATIQLDFQLPNR SYTC_YEAST 549 77 -
PKIDIQIKDAIGRYHQCATIQLDFQLPIR SYTC_HUMAN 530 77 -
PKISVQVKDALGRTWQMSTIQLDFNFPER SYT_MYCTU 505 79 -
PKIDITVSDAMNRKFQCATLQLDFQLPIR SYTC_ARATH 516 77 -
PKIEFTLYDCLDRAWQCGTVQLDFSLPSR SYT_ECOLI 464 78 -
PKIEFALRDCLGREWQCGTVQLDFALPGR SYT_HAEIN 464 78 -
PKIEFVLQDSLDRNWQCGTIQLDFYLPIR SYT_BUCAP 464 78 -
PKLDIMVTDHLRKTHQVATIQLDFQLPER SYTM_YEAST 272 87 -
PKIEFVLTDAIGRQWQCGTLQMDFVLPER SYT_RICPR 463 78 -
PKLDFIFQDALEREWQLGTVQVDYNLPER SYT_SYNY3 429 81 -
PKIDIKITDALKRKWQCGTIQVDMNLPER SYT_HELPY 439 77 -
LKFEFNFVDALDKASALSTVQIDVENAER SYT_ARCFU 417 76 -
AKMDFAAIDYLGRPIENPTVQIDVESGER SYT_METTH 411 73 -

Motif 4 width=14
Element Seqn Id St Int Rpt
PVMIHRAILGSVER SYTC_YEAST 595 17 -
PVIVHRAILGSVER SYTC_HUMAN 574 15 -
PVMIHRALFGSIER SYT_MYCTU 548 14 -
PVMIHRAVLGSVER SYTC_ARATH 560 15 -
PVMIHRAILGSMER SYT_ECOLI 507 14 -
PVMIHRAILGSIER SYT_HAEIN 507 14 -
PIIIHRAILGSIER SYT_BUCAP 507 14 -
PIMIHRATFGSIER SYTM_YEAST 315 14 -
PVMLHRAILGSLER SYT_RICPR 506 14 -
PVMIHRAPFGSLER SYT_SYNY3 472 14 -
PVMIHRAILGSFER SYT_HELPY 482 14 -
PYILHCSVSGAVER SYT_ARCFU 460 14 -
PIILHCSPTGSIER SYT_METTH 454 14 -

Motif 5 width=13
Element Seqn Id St Int Rpt
PFWLSPRQVLVVP SYTC_YEAST 622 13 -
PFWLSPRQVMVVP SYTC_HUMAN 602 14 -
PAWLAPVQVVGIP SYT_MYCTU 575 13 -
PFWISPRQAIVCP SYTC_ARATH 587 13 -
PTWLAPVQVVIMN SYT_ECOLI 534 13 -
PAWLAPTQAVVMN SYT_HAEIN 534 13 -
PTWLSPIQVVILS SYT_BUCAP 533 12 -
PFWLNPYQAVIIP SYTM_YEAST 342 13 -
PIWLAPVQVAIAT SYT_RICPR 533 13 -
PLWLAPIQVRLLA SYT_SYNY3 499 13 -
PFFVAPTQIALIP SYT_HELPY 509 13 -
PVWLSPTQVRVIP SYT_ARCFU 495 21 -
PLWLSPTQVRVLP SYT_METTH 488 20 -
Final Motifs
Motif 1  width=29
Element Seqn Id St Int Rpt
LKPMNCPGHCLMFKSRERSYRELPWRVAD SYTC_YEAST 415 415 -
LKPMNCPGHCVMFKSRDRSYRDLPWRVAD SYTC_SCHPO 376 376 -
LKPMNCPGHSLMFDHRPRSWRELPLRLAD SYTC_HUMAN 396 396 -
LKPMNCPGHCLIFQHRVRSYRELPLRLAD O81907 402 402 -
LKPMNCPMHCLIFRARGRSYRELPLRLFE SYT_MYCTU 369 369 -
LKPMNCPGHCLIFQHRVRSYRELPMRLAD SYTC_ARATH 382 382 -
IKPMNCPGHVQIFNQGLKSYRDLPLRMAE SYT_ECOLI 329 329 -
IKPMNCPGHVQIFNQGLKSYRDLPIRMAE SYT_HAEIN 329 329 -
LKPMNCPMHTLIFSSRGRSYRELPLRLFE SYT_MYCLE 379 379 -
VKPMNCPFHIAIYKSRTRSYKELPLKLFE O67583 331 331 -
LKPMNCPFHIAIYNTGKHSYRDLPFRWAE O51662 273 273 -
LKPMNCPGHCLMFGHMPHTYNELPFRFAD SYTC_CAEEL 407 407 -
IKPMNCPGHVQIFNCGLKSYRDLPIRMAE SYT_BUCAP 329 329 -
LKPMNCPGHCLIFGKKDRSYNELPLRFSD SYTM_YEAST 128 128 -
MKPMNCPGHMLIFKNSLYSYRDLPIRMAE SYT2_BACSU 331 331 -
LKPMNCPCHVQIFKQGIKSYRDLPLRMSE SYT_RICPR 328 328 -
LKPMNCPGHCIVYASTERSYKELPLRFAD SYTM_SCHPO 141 141 -
LKPMNCPFHIQIYKSELRSYRDLPLRLAE SYT_SYNY3 291 291 -
IKPMNCPGCMLYYKTQLHSYREFPLRIAE O84585 348 348 -
LKPMNCPGHVEIFKQKTRSYRDLPLRLSE SYT_TREPA 279 279 -
IKPMNCVGHIKVYQSALHSYRDLPLRFYE SYT_HELPY 305 305 -
LRPMTCPHHCLIFKHKRRSYKELPQRFCE SYT_MYCPN 255 255 -
LRPMNCPHHMMIYKQDIHSYRELPIRIAE SYT1_BACSU 333 333 -
LRPMTCPHHCLIFKQKRYSYKKMPQRFSE SYT_MYCGE 255 255 -
LRFAACFGQFLISKDAVISYRHLPLRMYE O58430 293 293 -
LRFAACFGQFMMKKDMYLLPRYLPLKLYE SYT_METJA 288 288 -
LRFAACFGQFLMLSSSTITYRNLPLKIYE SYT_ARCFU 283 283 -
LRYACCFGAFRILSDSFLTWKNLPASIYE SYT_METTH 280 280 -

Motif 2 width=24
Element Seqn Id St Int Rpt
HRNEFSGALSGLTRVRRFQQDDAH SYTC_YEAST 448 4 -
HRNEFSGALSGLTRVRRFQQDDAH SYTC_SCHPO 409 4 -
HRNELSGALTGLTRVRRFQQDDAH SYTC_HUMAN 429 4 -
HRNEASGALSGLTRVRRFQQDDAH O81907 435 4 -
YRYEKSGVVHGLTRVRGLTMDDAH SYT_MYCTU 402 4 -
HRNEASGALSGLTRVRRFQQDDAH SYTC_ARATH 415 4 -
HRNEPSGSLHGLMRVRGFTQDDAH SYT_ECOLI 362 4 -
HRNEPSGSLHGLMRVRGFTQDDAH SYT_HAEIN 362 4 -
YRYEKSGVVHGLTRARGFTMDDSH SYT_MYCLE 412 4 -
YRYELSGVLHGLLRVRGFTQDDAH O67583 364 4 -
YRYEKIGALHGMMRARGFTQDDAH O51662 306 4 -
HRNEMSGALTGLTRVRRFQQDDAH SYTC_CAEEL 440 4 -
HRNESSGSLHGLMRIRNFTQDDAH SYT_BUCAP 362 4 -
HRNEASGALSGLTRLRKFHQDDGH SYTM_YEAST 161 4 -
HRHEYSGALNGMLRVRTFCQDDAH SYT2_BACSU 364 4 -
HRNEASGALHGLMRVRSLVQDDAH SYT_RICPR 361 4 -
HRNEASGALSGLTRLRCFHQDDGH SYTM_SCHPO 174 4 -
YRYEQSGELGGLTRVRGFTVDDSH SYT_SYNY3 324 4 -
HRHELSGALSGLMRVRTFHQDDAH O84585 381 4 -
TRNEPSGSLHGVMRVRGFVQDDAH SYT_TREPA 312 4 -
HRHEKSGVLHGLLRVREFTQDDAH SYT_HELPY 338 4 -
HRFEASGGLTGLERVRCMTLLDNH SYT_MYCPN 288 4 -
HRYEMSGALSGLQRVRGMTLNDAH SYT1_BACSU 366 4 -
HRFEASGGLIGLERVRCMTLLDNH SYT_MYCGE 288 4 -
FRREKRGELSGLRRLRAFTMPDMH O58430 327 5 -
FRYEQRGELVGLKRLRCFTMPDMH SYT_METJA 322 5 -
FRKEQRGELVGLRRLRAFTMPDMH SYT_ARCFU 317 5 -
FRLEKKGEVVGLKRLRGFTMPDLH SYT_METTH 314 5 -

Motif 3 width=29
Element Seqn Id St Int Rpt
PKIDIMISDALRRWHQCATIQLDFQLPNR SYTC_YEAST 549 77 -
PKIDITVFDALKRQHQCATIQLDFQLPER SYTC_SCHPO 511 78 -
PKIDIQIKDAIGRYHQCATIQLDFQLPIR SYTC_HUMAN 530 77 -
PKIDITVSDAMNRKFQCATLQLDFQLPIR O81907 536 77 -
PKISVQVKDALGRTWQMSTIQLDFNFPER SYT_MYCTU 505 79 -
PKIDITVSDAMNRKFQCATLQLDFQLPIR SYTC_ARATH 516 77 -
PKIEFTLYDCLDRAWQCGTVQLDFSLPSR SYT_ECOLI 464 78 -
PKIEFALRDCLGREWQCGTVQLDFALPGR SYT_HAEIN 464 78 -
PKISVQVRDALGRSWQMSTIQVDFNFPER SYT_MYCLE 515 79 -
PKIDVKIRDAIGRMWQLSTIQFDFNLPER O67583 466 78 -
PKIDLKIVDSLEREWQMSTIQFDFNLPER O51662 408 78 -
PKIDITIQDALKRNFQCATIQLDFQLPNQ SYTC_CAEEL 542 78 -
PKIEFVLQDSLDRNWQCGTIQLDFYLPIR SYT_BUCAP 464 78 -
PKLDIMVTDHLRKTHQVATIQLDFQLPER SYTM_YEAST 272 87 -
PKIDFHIKDALKRSHQCATIQLDFQMPEK SYT2_BACSU 465 77 -
PKIEFVLTDAIGRQWQCGTLQMDFVLPER SYT_RICPR 463 78 -
PKIDVMVADARGKWHQTATIQLDFNLPQR SYTM_SCHPO 276 78 -
PKLDFIFQDALEREWQLGTVQVDYNLPER SYT_SYNY3 429 81 -
PKIDIHVKDAINRTWQCGTIQLDMFLPER O84585 483 78 -
PKLEFALIDTLEREWQCGTIQVDYQLPSC SYT_TREPA 416 80 -
PKIDIKITDALKRKWQCGTIQVDMNLPER SYT_HELPY 439 77 -
PKIDFQFKTALNKMITIATIQLDFLLPER SYT_MYCPN 394 82 -
PKLDVQVKTAIGKEETLSTVQLDFLLPER SYT1_BACSU 472 82 -
PKIDFQFKTIFKKMITIATIQLDFLLPEK SYT_MYCGE 394 82 -
LKFEFNFVDNLDKAAALSTVQIDVENAER O58430 427 76 -
GKVDIAVIDSLGRPIENPTVQIDVESAKR SYT_METJA 423 77 -
LKFEFNFVDALDKASALSTVQIDVENAER SYT_ARCFU 417 76 -
AKMDFAAIDYLGRPIENPTVQIDVESGER SYT_METTH 411 73 -

Motif 4 width=14
Element Seqn Id St Int Rpt
PVMIHRAILGSVER SYTC_YEAST 595 17 -
PVMVHRAILGSLER SYTC_SCHPO 565 25 -
PVIVHRAILGSVER SYTC_HUMAN 574 15 -
PVMIHRAVLGSVER O81907 580 15 -
PVMIHRALFGSIER SYT_MYCTU 548 14 -
PVMIHRAVLGSVER SYTC_ARATH 560 15 -
PVMIHRAILGSMER SYT_ECOLI 507 14 -
PVMIHRAILGSIER SYT_HAEIN 507 14 -
PVMIHRALFGSIER SYT_MYCLE 558 14 -
PYMIHRALLGSIER O67583 509 14 -
PFMIHRALLGSIER O51662 451 14 -
PVMIHRAVLGSVER SYTC_CAEEL 585 14 -
PIIIHRAILGSIER SYT_BUCAP 507 14 -
PIMIHRATFGSIER SYTM_YEAST 315 14 -
PVVIHRAVFGSIDR SYT2_BACSU 508 14 -
PVMLHRAILGSLER SYT_RICPR 506 14 -
PVMIHRAIFGSLER SYTM_SCHPO 326 21 -
PVMIHRAPFGSLER SYT_SYNY3 472 14 -
PIMLHRALFGSIER O84585 526 14 -
PVILHRTVIGSLER SYT_TREPA 461 16 -
PVMIHRAILGSFER SYT_HELPY 482 14 -
PVIIHVGIVGTYER SYT_MYCPN 437 14 -
PVVIHRGVVSTMER SYT1_BACSU 515 14 -
PVIIHVGIIGTYER SYT_MYCGE 437 14 -
PLILHCSPSGAIER O58430 470 14 -
PIILHCSPTGSIER SYT_METJA 465 13 -
PYILHCSVSGAVER SYT_ARCFU 460 14 -
PIILHCSPTGSIER SYT_METTH 454 14 -

Motif 5 width=13
Element Seqn Id St Int Rpt
PFWLSPRQVLVVP SYTC_YEAST 622 13 -
PFWMSPRQVCIIP SYTC_SCHPO 592 13 -
PFWLSPRQVMVVP SYTC_HUMAN 602 14 -
PFWISPRQAIVCP O81907 607 13 -
PAWLAPVQVVGIP SYT_MYCTU 575 13 -
PFWISPRQAIVCP SYTC_ARATH 587 13 -
PTWLAPVQVVIMN SYT_ECOLI 534 13 -
PAWLAPTQAVVMN SYT_HAEIN 534 13 -
PAWLAPIQVVGIP SYT_MYCLE 585 13 -
PIWLSPTQVMIIP O67583 536 13 -
PLWLSPVQVVIIP O51662 478 13 -
PFWLSPRQCKIIT SYTC_CAEEL 612 13 -
PTWLSPIQVVILS SYT_BUCAP 533 12 -
PFWLNPYQAVIIP SYTM_YEAST 342 13 -
PVWLAPIQVQIIP SYT2_BACSU 535 13 -
PIWLAPVQVAIAT SYT_RICPR 533 13 -
PFWLSPRHAVILP SYTM_SCHPO 353 13 -
PLWLAPIQVRLLA SYT_SYNY3 499 13 -
PLWLSPEHVRIIT O84585 553 13 -
PPWLAPVQAVVIP SYT_TREPA 488 13 -
PFFVAPTQIALIP SYT_HELPY 509 13 -
PLWMAPVQVVVIP SYT_MYCPN 464 13 -
PTWLAPVQFQVIP SYT1_BACSU 542 13 -
PLWLAPVQAVIIP SYT_MYCGE 464 13 -
PLWLSPIQVRVIP O58430 505 21 -
PVWLSPIQVRVIP SYT_METJA 500 21 -
PVWLSPTQVRVIP SYT_ARCFU 495 21 -
PLWLSPTQVRVLP SYT_METTH 488 20 -