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PR01042

Identifier
TRNASYNTHASP  [View Relations]  [View Alignment]  
Accession
PR01042
No. of Motifs
4
Creation Date
11-DEC-1998  (UPDATE 28-JUN-1999)
Title
Aspartyl-tRNA synthetase signature
Database References
PRINTS; PR90000 TRNASYNTH; PR90002 TRNASYNTHCLII
PROSITE; PS00179 AA_TRNA_LIGASE_II_1; PS00339 AA_TRNA_LIGASE_II_2
PFAM; PF01336 Aspartyl_tRNA_N
INTERPRO; IPR002312
PDB; 1ASY; 1ASZ
SCOP; 1ASY; 1ASZ
CATH; 1ASY
Literature References
1. LODISH, H., BALTIMORE, D., BERK, A., ZIPURSKY, S.L., MATSUDAIRA, P.
AND DARNELL, J.
Nucleic Acids, the Genetic Code, and Protein Synthesis. 
IN MOLECULAR CELL BIOLOGY, SCIENTIFIC AMERICAN BOOKS (NEW YORK), 1995,
PP.126-128.
 
2. DELARUE, M.
Aminoacyl-tRNA synthetases.
CURR.OPIN.STRUCT.BIOL. 5 48-55 (1995).
 
3. PERONA, J.J., ROULD, M. AND STEITZ, T.A.
Structural Basis for Transfer RNA Aminoacylation by Escherichia coli
Glutaminyl-tRNA Synthetase.
BIOCHEMISTRY 32 8758-8771 (1993).

Documentation
Appropriate attachment of an amino acid to its cognate tRNA is the key to
faithful translation of the genetic code. The family of enzymes responsible
for this is the aminoacyl-tRNA synthetases (AATRSs) (EC 6.1.1.-).
 
AATRSs catalyse a two-step reaction:
 
(1) Enzyme + amino acid + ATP ---> Enzyme(aminoacyl-AMP) + PPi
 
(2) tRNA + Enzyme(aminoacyl-AMP) ---> aminoacyl-tRNA + AMP + Enzyme
 
In the first step, they form an aminoacyl-adenylate, in which the carboxyl
of the amino acid is linked to the alpha-phosphate of ATP, by displacing
the pyrophosphate. When the correct tRNA is bound, the aminoacyl group is
transferred to the 2'- or 3'-terminal OH of the tRNA at the expense of AMP
[1].
 
Based on structural and sequence comparisons, this group of at least 20
proteins (in prokaryotes there are approximately 20, but in eukaryotes
there are usually 2 forms for each amino acid; namely, the cytosolic and
mitochondrial forms) can be divided into two classes.
 
Class I AATRSs contain a characteristic Rossman fold and are mostly
monomeric. At the primary structure level, two highly-conserved motifs
are observed, `HIGH' and `KMSKS' [2,3]; these are associated with the ATP-
binding site.
 
Class II AATRSs share an anti-parallel beta-sheet formation, flanked by
alpha-helices [3], and are mostly dimeric or multimeric.
 
Further distinction between the two classes is evident when the reaction
mechanisms are investigated. In reactions catalysed by the class I AATRSs,
the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in
class II reactions, the 3'-hydroxyl site is preferred.
 
Aspartyl-tRNA synthetase (EC 6.1.1.12) is specific to aspartate and belongs
to class II.
 
TRNASYNTHASP is a 4-element fingerprint that provides a signature for the
aspartyl-tRNA synthetase family. The fingerprint was derived from an initial
alignment of 6 sequences: the motifs were drawn from conserved regions
spanning the full alignment length - motif 1 includes helix 8; motifs 2 and
3 span the region encoded by PROSITE pattern AA_TRNA_LIGASE_II_1 (PS00179),
motif 2 including beta-strand 11 and motif 3 including strands 15 and 16;
and motif 4 spans the C-terminus of helix 14 and the N-terminus of strand
17. Three iterations on OWL31.1 were required to reach convergence, at which
point a true set comprising 34 sequences was identified. A single partial
match was found, SYD_PSEAE, a fragment that lacks the portion of sequence
bearing motifs 1 and 2.
 
An update on SPTR37_9f identified a true set of 44 sequences, and 20
partial matches.
Summary Information
  44 codes involving  4 elements
1 codes involving 3 elements
19 codes involving 2 elements
Composite Feature Index
444444444
31011
2019019
1234
True Positives
O57980        O58776        O74407        O81892        
O84546 P90831 SYDC_YEAST SYDM_YEAST
SYD_AQUAE SYD_ARCFU SYD_BACSU SYD_BORBU
SYD_BUCAP SYD_CAEEL SYD_ECOLI SYD_HAEIN
SYD_HALSA SYD_HELPY SYD_HUMAN SYD_METJA
SYD_METTH SYD_MYCGE SYD_MYCLE SYD_MYCPN
SYD_MYCTU SYD_PYRKO SYD_RAT SYD_SYNY3
SYD_THETH SYD_TREPA SYNC_YEAST SYNM_YEAST
SYN_BACSU SYN_BORBU SYN_CAEEL SYN_ECOLI
SYN_HAEIN SYN_HUMAN SYN_LACDE SYN_MYCGE
SYN_MYCPN SYN_SYNY3 SYN_THETH SYN_TREPA
True Positive Partials
Codes involving 3 elements
SYN_BRUMA
Codes involving 2 elements
O84786 O87821 SYK2_ECOLI SYKC_YEAST
SYKM_YEAST SYK_ACICA SYK_BACSU SYK_CAEEL
SYK_CAMJE SYK_CRILO SYK_HUMAN SYK_LYCES
SYK_MYCFE SYK_MYCHO SYK_MYCTU SYK_STAAU
SYK_SULSO SYK_SYNY3 SYK_THETH
Sequence Titles
O57980      434AA LONG HYPOTHETICAL ASPARAGINYL-TRNA SYNTHETASE - PYROCOCCUS HORIKOSHII. 
O58776 438AA LONG HYPOTHETICAL ASPARTYL-TRNA SYNTHETASE - PYROCOCCUS HORIKOSHII.
O74407 ASPARTYL-TRNA SYNTHETASE - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O81892 PUTATIVE ASPARTATE--TRNA LIGASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O84546 ASPARTYL TRNA SYNTHETASE - CHLAMYDIA TRACHOMATIS.
P90831 HYPOTHETICAL PROTEIN F10C2.6 - CAENORHABDITIS ELEGANS.
SYDC_YEAST ASPARTYL-TRNA SYNTHETASE, CYTOPLASMIC (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
SYDM_YEAST ASPARTYL-TRNA SYNTHETASE, MITOCHONDRIAL (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
SYD_AQUAE ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - AQUIFEX AEOLICUS.
SYD_ARCFU ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - ARCHAEOGLOBUS FULGIDUS.
SYD_BACSU ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - BACILLUS SUBTILIS.
SYD_BORBU ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - BORRELIA BURGDORFERI (LYME DISEASE SPIROCHETE).
SYD_BUCAP ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - BUCHNERA APHIDICOLA.
SYD_CAEEL PROBABLE ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - CAENORHABDITIS ELEGANS.
SYD_ECOLI ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - ESCHERICHIA COLI.
SYD_HAEIN ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - HAEMOPHILUS INFLUENZAE.
SYD_HALSA ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - HALOBACTERIUM SALINARIUM.
SYD_HELPY ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
SYD_HUMAN ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - HOMO SAPIENS (HUMAN).
SYD_METJA ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - METHANOCOCCUS JANNASCHII.
SYD_METTH ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - METHANOBACTERIUM THERMOAUTOTROPHICUM.
SYD_MYCGE ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - MYCOPLASMA GENITALIUM.
SYD_MYCLE ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) (ANTIGEN T5) - MYCOBACTERIUM LEPRAE.
SYD_MYCPN ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - MYCOPLASMA PNEUMONIAE.
SYD_MYCTU ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - MYCOBACTERIUM TUBERCULOSIS.
SYD_PYRKO ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - PYROCOCCUS KODAKARAENSIS.
SYD_RAT ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - RATTUS NORVEGICUS (RAT).
SYD_SYNY3 ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
SYD_THETH ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - THERMUS AQUATICUS (SUBSP. THERMOPHILUS).
SYD_TREPA ASPARTYL-TRNA SYNTHETASE (EC 6.1.1.12) (ASPARTATE--TRNA LIGASE) (ASPRS) - TREPONEMA PALLIDUM.
SYNC_YEAST ASPARAGINYL-TRNA SYNTHETASE, CYTOPLASMIC (EC 6.1.1.22) (ASPARAGINE-- TRNA LIGASE) (ASNRS) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
SYNM_YEAST ASPARAGINYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR (EC 6.1.1.22) (ASPARAGINE--TRNA LIGASE) (ASNRS) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
SYN_BACSU ASPARAGINYL-TRNA SYNTHETASE (EC 6.1.1.22) (ASPARAGINE--TRNA LIGASE) (ASNRS) - BACILLUS SUBTILIS.
SYN_BORBU ASPARAGINYL-TRNA SYNTHETASE (EC 6.1.1.22) (ASPARAGINE--TRNA LIGASE) (ASNRS) - BORRELIA BURGDORFERI (LYME DISEASE SPIROCHETE).
SYN_CAEEL PROBABLE ASPARAGINYL-TRNA SYNTHETASE, CYTOPLASMIC (EC 6.1.1.22) (ASPARAGINE--TRNA LIGASE) (ASNRS) - CAENORHABDITIS ELEGANS.
SYN_ECOLI ASPARAGINYL-TRNA SYNTHETASE (EC 6.1.1.22) (ASPARAGINE--TRNA LIGASE) (ASNRS) - ESCHERICHIA COLI.
SYN_HAEIN ASPARAGINYL-TRNA SYNTHETASE (EC 6.1.1.22) (ASPARAGINE--TRNA LIGASE) (ASNRS) - HAEMOPHILUS INFLUENZAE.
SYN_HUMAN ASPARAGINYL-TRNA SYNTHETASE, CYTOPLASMIC (EC 6.1.1.22) (ASPARAGINE-- TRNA LIGASE) (ASNRS) - HOMO SAPIENS (HUMAN).
SYN_LACDE ASPARAGINYL-TRNA SYNTHETASE (EC 6.1.1.22) (ASPARAGINE--TRNA LIGASE) (ASNRS) - LACTOBACILLUS DELBRUECKII (SUBSP. BULGARICUS).
SYN_MYCGE ASPARAGINYL-TRNA SYNTHETASE (EC 6.1.1.22) (ASPARAGINE--TRNA LIGASE) (ASNRS) - MYCOPLASMA GENITALIUM.
SYN_MYCPN ASPARAGINYL-TRNA SYNTHETASE (EC 6.1.1.22) (ASPARAGINE--TRNA LIGASE) (ASNRS) - MYCOPLASMA PNEUMONIAE.
SYN_SYNY3 PROBABLE ASPARAGINYL-TRNA SYNTHETASE (EC 6.1.1.22) (ASPARAGINE--TRNA LIGASE) (ASNRS) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
SYN_THETH ASPARAGINYL-TRNA SYNTHETASE (EC 6.1.1.22) (ASPARAGINE--TRNA LIGASE) (ASNRS) - THERMUS AQUATICUS (SUBSP. THERMOPHILUS).
SYN_TREPA ASPARAGINYL-TRNA SYNTHETASE (EC 6.1.1.22) (ASPARAGINE--TRNA LIGASE) (ASNRS) - TREPONEMA PALLIDUM.

SYN_BRUMA ASPARAGINYL-TRNA SYNTHETASE, CYTOPLASMIC (EC 6.1.1.22) (ASPARAGINE-- TRNA LIGASE) (ASNRS) (POTENTIALLY PROTECTIVE 63 KD ANTIGEN) - BRUGIA MALAYI.

O84786 LYSYL TRNA SYNTHETASE - CHLAMYDIA TRACHOMATIS.
O87821 LYSYL-TRNA SYNTHETASE - SINORHIZOBIUM MELILOTI.
SYK2_ECOLI LYSYL-TRNA SYNTHETASE, HEAT INDUCIBLE (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - ESCHERICHIA COLI.
SYKC_YEAST LYSYL-TRNA SYNTHETASE, CYTOPLASMIC (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
SYKM_YEAST LYSYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
SYK_ACICA LYSYL-TRNA SYNTHETASE (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - ACINETOBACTER CALCOACETICUS.
SYK_BACSU LYSYL-TRNA SYNTHETASE (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - BACILLUS SUBTILIS.
SYK_CAEEL PROBABLE LYSYL-TRNA SYNTHETASE (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - CAENORHABDITIS ELEGANS.
SYK_CAMJE LYSYL-TRNA SYNTHETASE (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - CAMPYLOBACTER JEJUNI.
SYK_CRILO LYSYL-TRNA SYNTHETASE (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - CRICETULUS LONGICAUDATUS (LONG-TAILED HAMSTER) (CHINESE HAMSTER).
SYK_HUMAN LYSYL-TRNA SYNTHETASE (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) (KIAA0070) - HOMO SAPIENS (HUMAN).
SYK_LYCES LYSYL-TRNA SYNTHETASE (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - LYCOPERSICON ESCULENTUM (TOMATO).
SYK_MYCFE LYSYL-TRNA SYNTHETASE (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - MYCOPLASMA FERMENTANS.
SYK_MYCHO LYSYL-TRNA SYNTHETASE (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - MYCOPLASMA HOMINIS.
SYK_MYCTU LYSYL-TRNA SYNTHETASE (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - MYCOBACTERIUM TUBERCULOSIS.
SYK_STAAU LYSYL-TRNA SYNTHETASE (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - STAPHYLOCOCCUS AUREUS.
SYK_SULSO LYSYL-TRNA SYNTHETASE (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - SULFOLOBUS SOLFATARICUS.
SYK_SYNY3 LYSYL-TRNA SYNTHETASE (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
SYK_THETH LYSYL-TRNA SYNTHETASE (EC 6.1.1.6) (LYSINE--TRNA LIGASE) (LYSRS) - THERMUS AQUATICUS (SUBSP. THERMOPHILUS).
Scan History
OWL31_1    3  38   NSINGLE    
SPTR37_9f 4 70 NSINGLE
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
LPQSPQLFKQLLM SYD_MYCLE 189 189 -
LAQSPQLYKQMAI SYD_CAEEL 276 276 -
LPQSPQLFKQLLM SYD_MYCCA 147 147 -
LAQSPQLYKQMCI SYD_HUMAN 245 245 -
LPQSPQLFKQLLM SYD_ECOLI 190 190 -
LPQSPQLFKQLLM SYD_HAEIN 191 191 -

Motif 2 width=14
Element Seqn Id St Int Rpt
EKVYTIGPVFRAED SYD_CAEEL 293 4 -
DRYYQIVRCFRDED SYD_MYCCA 164 4 -
DRYYQIVKCFRDED SYD_ECOLI 207 4 -
DRYYQIVKCFRDED SYD_HAEIN 208 4 -
ERYYQIAHCYRDED SYD_MYCLE 206 4 -
EKVFSIGPVFRAED SYD_HUMAN 262 4 -

Motif 3 width=17
Element Seqn Id St Int Rpt
YDLVMNGFEIGGGSQRI SYD_MYCCA 423 245 -
YDMVINGYEVGGGSVRI SYD_ECOLI 474 253 -
YDMVINGYEVGGGSVRI SYD_HAEIN 475 253 -
YDIVCNGHEIGSGSVRI SYD_MYCLE 474 254 -
YDMFMRGEEILSGAQRI SYD_CAEEL 446 139 -
YDMFMRGEEILSGAQRI SYD_HUMAN 415 139 -

Motif 4 width=15
Element Seqn Id St Int Rpt
IDSFKYGCPPHAGGG SYD_CAEEL 486 23 -
IDSFRFGAPPHAGGG SYD_HUMAN 455 23 -
LDALKYGTPPHAGLA SYD_ECOLI 518 27 -
MNAYKYGAPYHAGIA SYD_MYCCA 467 27 -
LDALKFGTPPHAGLA SYD_HAEIN 519 27 -
LEAFTFGAPPHGGIA SYD_MYCLE 518 27 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
LPQSPQLFKQLLM SYD_SYNY3 197 197 -
LPQSPQLFKQLLM SYD_BACSU 196 196 -
LPQSPQLFKQMLM SYD_THETH 196 196 -
LPQSPQLFKQLLM SYD_HELPY 190 190 -
LPQSPQLFKQILM SYD_AQUAE 201 201 -
LPQSPQLFKQMLM O81892 248 248 -
LPQSPQLFKQILM SYD_BUCAP 188 188 -
LPQSPQLFKQLLM SYD_ECOLI 190 190 -
LPQSPQLFKQILM O84546 196 196 -
LPQSPQLFKQLLM SYD_MYCTU 194 194 -
LPQSPQLFKQLLM SYD_HAEIN 191 191 -
LPQSPQLYKQLLM SYD_TREPA 210 210 -
LPQSPQLFKQLLM SYD_MYCLE 189 189 -
LPQSPQLYKQLIM SYD_BORBU 111 111 -
LGQSPQLYKQMLM SYD_METJA 193 193 -
LAQSPQLYKQIMM SYD_PYRKO 187 187 -
LAQSPQLYKQMMM O58776 187 187 -
LAQSPQLYKQMAI SYD_CAEEL 276 276 -
LPQSPQQFKQLLM P90831 186 186 -
LDQSPQQYKQLLM SYDM_YEAST 221 221 -
LVQSPQIYKQLLM SYD_MYCGE 181 181 -
LNQSPQLYKQVLM SYD_ARCFU 185 185 -
LSQSPQLYKQMLI O74407 304 304 -
LAQSPQLYKQMCI SYD_HUMAN 245 245 -
LAQSPQLYKQMCI SYD_RAT 246 246 -
LPQSPQIYKQLLM SYD_MYCPN 187 187 -
LGQSPQLYKQIMM SYD_METTH 192 192 -
LSQSPQLYKQILV SYD_HALSA 186 186 -
LAQSPQFNKQQLI SYDC_YEAST 297 297 -
LSQSGQLYAEAGA SYN_THETH 182 182 -
LTVSGQLEAEVMA SYN_SYNY3 255 255 -
LSQSGQLYMEAAA SYN_BACSU 180 180 -
LSQSGQLYGEVGA SYN_LACDE 182 182 -
LTQSSQLYLETCL SYNC_YEAST 301 301 -
LTVSGQLNGETYA SYN_HAEIN 219 219 -
LTVSGQLNGETYA SYN_ECOLI 207 207 -
LTVSGQLQGEAYA SYN_TREPA 239 239 -
LSQSAQLYLEAAI O57980 185 185 -
LTQSSQLYLETCL SYN_HUMAN 296 296 -
LTQSSQLYLETCN SYN_CAEEL 292 292 -
LSVTGQLHGEAYA SYN_BORBU 208 208 -
LTVSTQLHLEILA SYNM_YEAST 213 213 -
LTVSGQFGAEAFA SYN_MYCGE 191 191 -
LTVSGQFGAECYA SYN_MYCPN 190 190 -

Motif 2 width=14
Element Seqn Id St Int Rpt
DRYYQIARCFRDED SYD_SYNY3 214 4 -
ERYYQIARCFRDED SYD_BACSU 213 4 -
DRYFQIARCFRDED SYD_THETH 213 4 -
DRYFQIARCFRDED SYD_HELPY 207 4 -
DRYFQIVKCFRDED SYD_AQUAE 218 4 -
DKYYQIARCFRDED O81892 265 4 -
DKYYQIVKCFRDED SYD_BUCAP 205 4 -
DRYYQIVKCFRDED SYD_ECOLI 207 4 -
DRYFQIATCFRDED O84546 213 4 -
ERYYQIARCYRDED SYD_MYCTU 211 4 -
DRYYQIVKCFRDED SYD_HAEIN 208 4 -
DRYFQLARCYRDED SYD_TREPA 227 4 -
ERYYQIAHCYRDED SYD_MYCLE 206 4 -
DKYFQIARCYRDED SYD_BORBU 128 4 -
DRVFEIAPIFRAEE SYD_METJA 210 4 -
DRVYEIAPIFRAEE SYD_PYRKO 204 4 -
DKVFEIAPIFRAEE O58776 204 4 -
EKVYTIGPVFRAED SYD_CAEEL 293 4 -
DRYFQIARCYRDEG P90831 203 4 -
NKYYQMARCFRDED SYDM_YEAST 238 4 -
EKYFQIARVYRDED SYD_MYCGE 198 4 -
EKVFEIGPIFRAEE SYD_ARCFU 202 4 -
ERVFEIGPVFRAED O74407 321 4 -
EKVFSIGPVFRAED SYD_HUMAN 262 4 -
EKVFCIGPVFRAED SYD_RAT 263 4 -
EKYFQIAHVYRDED SYD_MYCPN 204 4 -
DRVYEIAPIFRAEE SYD_METTH 209 4 -
DRLFEVGHAFRAED SYD_HALSA 203 4 -
ERVYEIGPVFRAEN SYDC_YEAST 314 4 -
AKVYTFGPTFRAER SYN_THETH 198 3 -
QNVYTFGPTFRAEN SYN_SYNY3 271 3 -
GKVFSFGPTFRAEK SYN_BACSU 196 3 -
GKIFTFGPTFRAEA SYN_LACDE 198 3 -
GDVYTIQESFRAEK SYNC_YEAST 317 3 -
SKIYTFGPTFRAEN SYN_HAEIN 235 3 -
SKIYTFGPTFRAEN SYN_ECOLI 223 3 -
TRIYTFGPTFRAEN SYN_TREPA 255 3 -
EKVWSLTPSFRAEK O57980 201 3 -
GDVFCIAQSYRAEQ SYN_HUMAN 312 3 -
GDVYCISQSYRAEK SYN_CAEEL 308 3 -
SKIYTFGPTFRAEN SYN_BORBU 224 3 -
SRCWTLSPCFRAEK SYNM_YEAST 229 3 -
KKVFTFGPTFRAEK SYN_MYCGE 207 3 -
KKVFTFGPTFRAEK SYN_MYCPN 206 3 -

Motif 3 width=17
Element Seqn Id St Int Rpt
YDLVMNGVEIGGGSLRI SYD_SYNY3 480 252 -
YDLVLNGYELGGGSIRI SYD_BACSU 477 250 -
YDLVLNGVEVGGGSIRI SYD_THETH 468 241 -
YDVVLNGVELGGGSIRI SYD_HELPY 466 245 -
YDMVLNGEEIGGGSIRI SYD_AQUAE 492 260 -
YDMVYNGVEIGGGSLRI O81892 526 247 -
YDLVINGYEIGGGSVRI SYD_BUCAP 472 253 -
YDMVINGYEVGGGSVRI SYD_ECOLI 474 253 -
YDLVLNGYEIASGSQRI O84546 473 246 -
YDIVCNGHEIGGGSVRI SYD_MYCTU 479 254 -
YDMVINGYEVGGGSVRI SYD_HAEIN 475 253 -
YDLVLNGYELASGSIRI SYD_TREPA 491 250 -
YDIVCNGHEIGSGSVRI SYD_MYCLE 474 254 -
YDLVLNGVELGSGSIRI SYD_BORBU 392 250 -
FDLMYKDLEISSGAQRI SYD_METJA 353 129 -
FDLEYRGVEISSGGQRE SYD_PYRKO 353 135 -
FDLEYRGVEISSGGQRE O58776 353 135 -
YDMFMRGEEILSGAQRI SYD_CAEEL 446 139 -
YDLVINGVEMGGGSIRI P90831 454 237 -
YDLVVNGVELGGGSTRI SYDM_YEAST 545 293 -
FDLVLNGFEIGSGSIRI SYD_MYCGE 443 231 -
FDLMHGWLELSSGAQRI SYD_ARCFU 345 129 -
YDFFMKGQEIMSGAQRI O74407 494 159 -
YDMFMRGEEILSGAQRI SYD_HUMAN 415 139 -
YDMFMRGEEILSGAQRI SYD_RAT 416 139 -
YDLVLNGFELGSGSIRI SYD_MYCPN 449 231 -
FDLMYRDLEISSGAMRV SYD_METTH 352 129 -
FDLLYRGQELSSGGQRE SYD_HALSA 351 134 -
YDFFMRGEEILSGAQRI SYDC_YEAST 469 141 -
LLRPEGYGEIIGGSQRI SYN_THETH 353 141 -
DILAPKIGEIIGGSQRE SYN_SYNY3 428 143 -
LIAPEGYGEIIGGSERI SYN_BACSU 345 135 -
VEAPEGYGEIMGGSERE SYN_LACDE 347 135 -
DVLMPNVGEITGGSMRI SYNC_YEAST 469 138 -
DVLAPGIGEIIGGSQRE SYN_HAEIN 392 143 -
DVLAPGIGEIIGGSQRE SYN_ECOLI 380 143 -
DLLVPGLGEIMGGSERE SYN_TREPA 438 169 -
MLAPEGYGEIIGGSQRE O57980 349 134 -
DVLMPNVGEIVGGSMRI SYN_HUMAN 463 137 -
DLLMPGVGEIVGGSMRI SYN_CAEEL 460 138 -
DILVPKIGEIIGGSERE SYN_BORBU 381 143 -
DLLVPGMGEIIGGSLRE SYNM_YEAST 405 162 -
DLLLPKIGEICGGSERE SYN_MYCGE 371 150 -
DLLFPQIGEICGGSERE SYN_MYCPN 370 150 -

Motif 4 width=15
Element Seqn Id St Int Rpt
LDAFEYGTPPHGGIA SYD_SYNY3 524 27 -
LEAFEYGAPPHGGIA SYD_BACSU 521 27 -
LEALEYGAPPHGGIA SYD_THETH 512 27 -
LEALKFGAPPHGGFA SYD_HELPY 510 27 -
LEALKYGAPPHGGLA SYD_AQUAE 536 27 -
LEALDMGAPPHGGIA O81892 570 27 -
IEALKYGPPPHAGIA SYD_BUCAP 516 27 -
LDALKYGTPPHAGLA SYD_ECOLI 518 27 -
IDALSFGTPPHLGIA O84546 517 27 -
LEAFMFGAPPHGGIA SYD_MYCTU 523 27 -
LDALKFGTPPHAGLA SYD_HAEIN 519 27 -
TEAFKYGAPPHGGIA SYD_TREPA 535 27 -
LEAFTFGAPPHGGIA SYD_MYCLE 518 27 -
LKALEYGAPNHGGIA SYD_BORBU 436 27 -
LEAFKYGMPPHAGWG SYD_METJA 393 23 -
LKAFRYGMPPHGGFG SYD_PYRKO 393 23 -
LKAFEYGMPPHGGFG O58776 393 23 -
IDSFKYGCPPHAGGG SYD_CAEEL 486 23 -
LNALSHGAPPHGGFA P90831 494 23 -
LNAFDMGTPPHAGFA SYDM_YEAST 588 26 -
LEAYQYGAPVHGGMG SYD_MYCGE 483 23 -
LEAFRYGMPPHAGWG SYD_ARCFU 385 23 -
IDAFAIGCPPHAGGG O74407 535 24 -
IDSFRFGAPPHAGGG SYD_HUMAN 455 23 -
IDSFRFGAPPHAGGG SYD_RAT 456 23 -
MEAYQYGAPVHAGMG SYD_MYCPN 489 23 -
LSAFEYGMPPHAGWG SYD_METTH 392 23 -
LDAFRYGVPPHGGYG SYD_HALSA 391 23 -
CDGFSYGCPPHAGGG SYDC_YEAST 511 25 -
LDLRRFGSVPHSGFG SYN_THETH 393 23 -
LDLRRYGSVPHAGFG SYN_SYNY3 468 23 -
AELRKYGSVPHSGFG SYN_BACSU 385 23 -
LDLRKYGSVPHSGFG SYN_LACDE 387 23 -
IDQRKYGTCPHGGYG SYNC_YEAST 509 23 -
RDLRKYGSVPHSGFG SYN_HAEIN 432 23 -
RDLRRYGTVPHSGFG SYN_ECOLI 420 23 -
TDLRRFGTAPHAGFG SYN_TREPA 478 23 -
LDLRRYGSVPHSGFG O57980 389 23 -
TDQRKYGTCPHGGYG SYN_HUMAN 503 23 -
MDQRKYGSVPHGGYG SYN_CAEEL 500 23 -
LDLRRFGSAPHSGFG SYN_BORBU 421 23 -
VSLRKEGSAPHGGFG SYNM_YEAST 446 24 -
LDMRKWGYFASAGFG SYN_MYCGE 411 23 -
LDMRKWGYFASAGFG SYN_MYCPN 410 23 -