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PR00987

Identifier
TRNASYNTHGLU  [View Relations]  [View Alignment]  
Accession
PR00987
No. of Motifs
5
Creation Date
17-SEP-1998  (UPDATE 29-JUL-1999)
Title
Glutamyl-tRNA synthetase signature
Database References
PRINTS; PR90000 TRNASYNTH; PR90001 TRNASYNTHCLI
PROSITE; PS00178 AA_TRNA_LIGASE_I
PFAM; PF00749 TRNA-SYNT_1C
INTERPRO; IPR000924
PDB; 1GLN
SCOP; 1GLN
CATH; 1GLN
Literature References
1. LODISH, H., BALTIMORE, D., BERK, A., ZIPURSKY, S.L., MATSUDAIRA, P.
AND DARNELL, J.
Nucleic Acids, the Genetic Code, and Protein Synthesis. 
IN MOLECULAR CELL BIOLOGY, SCIENTIFIC AMERICAN BOOKS (NEW YORK), 1995,
PP.126-128
 
2. DELARUE, M.
Aminoacyl-tRNA synthetases.
CURR.OPIN.STRUCT.BIOL. 5 48-55 (1995).
 
3. PERONA, J.J., ROULD, M. AND STEITZ, T.A.
Structural Basis for Transfer RNA Aminoacylation by Escherichia coli
Glutaminyl-tRNA Synthetase.
BIOCHEMISTRY 32 8758-8771 (1993).

Documentation
Appropriate attachment of an amino acid to its cognate tRNA is the key to
faithful translation of the genetic code. The family of enzymes responsible
for this is the aminoacyl-tRNA synthetases (AATRSs) (EC 6.1.1.-).
 
AATRSs catalyse a two-step reaction:
 
(1) Enzyme + amino acid + ATP ---> Enzyme(aminoacyl-AMP) + PPi
 
(2) tRNA + Enzyme(aminoacyl-AMP) ---> aminoacyl-tRNA + AMP + Enzyme
 
In the first step, they form an aminoacyl-adenylate, in which the carboxyl
of the amino acid is linked to the alpha-phosphate of ATP, by displacing
the pyrophosphate. When the correct tRNA is bound, the aminoacyl group is
transferred to the 2'- or 3'-terminal OH of the tRNA at the expense of AMP
[1].
 
Based on structural and sequence comparisons, this group of at least 20
proteins (in prokaryotes there are approximately 20, but in eukaryotes
there are usually 2 forms for each amino acid; namely, the cytosolic and
mitochondrial forms) can be divided into two classes.
 
Class I AATRSs contain a characteristic Rossman fold and are mostly
monomeric. At the primary structure level, two highly-conserved motifs
are observed, `HIGH' and `KMSKS' [2,3]; these are associated with the ATP-
binding site.
 
Class II AATRSs share an anti-parallel beta-sheet formation, flanked by
alpha-helices [3], and are mostly dimeric or multimeric.
 
Further distinction between the two classes is evident when the reaction
mechanisms are investigated. In reactions catalysed by the class I AATRSs,
the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in
class II reactions, the 3'-hydroxyl site is preferred.
 
Glutamyl-tRNA synthetase (EC 6.1.1.11) is specific to glutamate and belongs
to class I.
 
TRNASYNTHGLU is a 5-element fingerprint that provides a signature for 
glutamyl-tRNA synthetases. The fingerprint was derived from an initial
alignment of 18 sequences: the motifs were drawn from conserved regions
within the C-terminal portion of the alignment - motif 1 spans the loop
between beta-strand 1 and alpha-helix 1, and is characterised by the `HIGH'
motif encoded by PROSITE pattern AA_TRNA_LIGASE_I (PS00178); motif 2 
includes helix 1; motif 3 spans strand 2; motif 4 includes helix 8, whose 
N-terminus denotes the boundary between domains 1 and 2; and motif 5 spans 
strand 8 and the N-terminus of helix 9. Two iterations on OWL30.2 were
required to reach convergence, at which point a true set comprising 36 
sequences was identified. Several partial matches were also found: most of
those matching three motifs are fragments, but some are glutaminyl-tRNA
synthetases and one is an arginyl-tRNA synthetase.
 
An update on SPTR37_9f identified a true set of 40 sequences, and 7
partial matches.
Summary Information
  40 codes involving  5 elements
0 codes involving 4 elements
1 codes involving 3 elements
6 codes involving 2 elements
Composite Feature Index
54040404040
400000
310110
261500
12345
True Positives
O13775        O25360        O33120        O44413        
O51345 O53241 O59314 O65253
O67271 O82462 O84451 O86528
P94662 Q23315 SYEC_YEAST SYEM_YEAST
SYEP_DROME SYEP_HUMAN SYE_ARCFU SYE_AZOBR
SYE_BACST SYE_BACSU SYE_ECOLI SYE_HAEIN
SYE_HELPY SYE_HORVU SYE_LACDE SYE_METJA
SYE_METTH SYE_METTM SYE_MYCGE SYE_MYCPN
SYE_MYCPU SYE_RHIME SYE_SULSO SYE_SYNY3
SYE_THETH SYE_TOBAC SYE_TREPA YADB_ECOLI
True Positive Partials
Codes involving 3 elements
SYQ_YEAST
Codes involving 2 elements
O62431 SYQ_ECOLI SYQ_HAEIN SYQ_HUMAN
SYQ_LUPLU SYR_HELPY
Sequence Titles
O13775      PUTATIVE GLUTAMYL-TRNA SYNTHETASE, CYTOPLASMIC (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST). 
O25360 GLUTAMYL-TRNA SYNTHETASE (GLTX) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O33120 GLUTAMYL-TRNA SYNTHASE - MYCOBACTERIUM LEPRAE.
O44413 T07A9.2 PROTEIN - CAENORHABDITIS ELEGANS.
O51345 GLUTAMYL-TRNA SYNTHETASE (GLTX) - BORRELIA BURGDORFERI (LYME DISEASE SPIROCHETE).
O53241 GLUTAMYL-TRNA SYNTHASE - MYCOBACTERIUM TUBERCULOSIS.
O59314 GLUTAMYL-TRNA SYNTHETASE - PYROCOCCUS HORIKOSHII.
O65253 F21E10.12 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O67271 GLUTAMYL-TRNA SYNTHETASE - AQUIFEX AEOLICUS.
O82462 GLUTAMYL-TRNA SYNTHETASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O84451 GLUTAMYL-TRNA SYNTHETASE - CHLAMYDIA TRACHOMATIS.
O86528 GLUTAMYL-TRNA SYNTHETASE - STREPTOMYCES COELICOLOR.
P94662 GLUTAMYL-TRNA SYNTHETASE HOMOLOG - CHLAMYDIA PSITTACI.
Q23315 ZC434.5 PROTEIN - CAENORHABDITIS ELEGANS.
SYEC_YEAST GLUTAMYL-TRNA SYNTHETASE, CYTOPLASMIC (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) (P85) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
SYEM_YEAST GLUTAMYL-TRNA SYNTHETASE, MITOCHONDRIAL (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
SYEP_DROME MULTIFUNCTIONAL AMINOACYL-TRNA SYNTHETASE [INCLUDES: GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE); PROLYL-TRNA SYNTHETASE (EC 6.1.1.15) (PROLINE--TRNA LIGASE)] - DROSOPHILA MELANOGASTER (FRUIT FLY).
SYEP_HUMAN MULTIFUNCTIONAL AMINOACYL-TRNA SYNTHETASE [INCLUDES: GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE); PROLYL-TRNA SYNTHETASE (EC 6.1.1.15) (PROLINE--TRNA LIGASE)] - HOMO SAPIENS (HUMAN).
SYE_ARCFU GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - ARCHAEOGLOBUS FULGIDUS.
SYE_AZOBR GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - AZOSPIRILLUM BRASILENSE.
SYE_BACST GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - BACILLUS STEAROTHERMOPHILUS.
SYE_BACSU GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - BACILLUS SUBTILIS.
SYE_ECOLI GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - ESCHERICHIA COLI.
SYE_HAEIN GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - HAEMOPHILUS INFLUENZAE.
SYE_HELPY GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
SYE_HORVU GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - HORDEUM VULGARE (BARLEY).
SYE_LACDE GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - LACTOBACILLUS DELBRUECKII (SUBSP. BULGARICUS).
SYE_METJA GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - METHANOCOCCUS JANNASCHII.
SYE_METTH GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - METHANOBACTERIUM THERMOAUTOTROPHICUM.
SYE_METTM GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - METHANOBACTERIUM THERMOAUTOTROPHICUM (STRAIN MARBURG / DSM 2133).
SYE_MYCGE GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - MYCOPLASMA GENITALIUM.
SYE_MYCPN GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - MYCOPLASMA PNEUMONIAE.
SYE_MYCPU GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - MYCOPLASMA PULMONIS.
SYE_RHIME GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - RHIZOBIUM MELILOTI.
SYE_SULSO GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - SULFOLOBUS SOLFATARICUS.
SYE_SYNY3 GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
SYE_THETH GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - THERMUS AQUATICUS (SUBSP. THERMOPHILUS).
SYE_TOBAC GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - NICOTIANA TABACUM (COMMON TOBACCO).
SYE_TREPA GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17) (GLUTAMATE--TRNA LIGASE) (GLURS) - TREPONEMA PALLIDUM.
YADB_ECOLI HYPOTHETICAL 34.9 KD PROTEIN IN PCNB-DKSA INTERGENIC REGION - ESCHERICHIA COLI.

SYQ_YEAST GLUTAMINYL-TRNA SYNTHETASE (EC 6.1.1.18) (GLUTAMINE--TRNA LIGASE) (GLNRS) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).

O62431 Y41E3.4 PROTEIN - CAENORHABDITIS ELEGANS.
SYQ_ECOLI GLUTAMINYL-TRNA SYNTHETASE (EC 6.1.1.18) (GLUTAMINE--TRNA LIGASE) (GLNRS) - ESCHERICHIA COLI.
SYQ_HAEIN GLUTAMINYL-TRNA SYNTHETASE (EC 6.1.1.18) (GLUTAMINE--TRNA LIGASE) (GLNRS) - HAEMOPHILUS INFLUENZAE.
SYQ_HUMAN GLUTAMINYL-TRNA SYNTHETASE (EC 6.1.1.18) (GLUTAMINE--TRNA LIGASE) (GLNRS) - HOMO SAPIENS (HUMAN).
SYQ_LUPLU GLUTAMINYL-TRNA SYNTHETASE (EC 6.1.1.18) (GLUTAMINE--TRNA LIGASE) (GLNRS) - LUPINUS LUTEUS (YELLOW LUPINE).
SYR_HELPY ARGINYL-TRNA SYNTHETASE (EC 6.1.1.19) (ARGININE--TRNA LIGASE) (ARGRS) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
Scan History
OWL30_2    2  100  NSINGLE    
SPTR37_9f 2 210 NSINGLE
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
RYAPSPTGYLHVG SYE_MYCPN 7 7 -
RIAPSPTGEPHVG SYE_RHIME 9 9 -
RFAPNPSGPLHIG SYE_METTH 99 99 -
RFAPNPDGPLHLG SYE_SULSO 105 105 -
RIAPSPTGDPHVG SYE_THETH 5 5 -
RFAPNPSGPLHIG SYE_METJA 95 95 -
RFAPSPTGLLHVG SYE_AZOBR 6 6 -
RFPPEASGYLHIG SYEP_HUMAN 129 129 -
RFAPNPNGPPTLG D69282 97 97 -
RFAPSPTGDMHIG C64600 3 3 -
RYAPSPTGHLHIG SYE_BACSU 8 8 -
RFAPSPTGYLHVG SYE_ECOLI 6 6 -
RYAPSPTGYLHIG SYE_MYCPU 7 7 -
GYAPSPTGHLHIG SYE_BACST 8 8 -
RIAPSPTGNLHIG SYE_SYNY3 6 6 -
RFAPSPTGYLHVG SYE_HAEIN 18 18 -
RFAPSPTGNLHVG SYE_TOBAC 59 59 -
RFAPSPTGYLHIG SYE_HELPY 7 7 -

Motif 2 width=12
Element Seqn Id St Int Rpt
AYIALFNYLFAK SYE_RHIME 23 1 -
ARSAILSYEYAK SYE_SULSO 119 1 -
AYIALFNYAWAR SYE_THETH 19 1 -
LRAAIFNYIVAK C64600 17 1 -
ARGIIVNGEYAK D69282 111 1 -
AKAALLNQHYQV SYEP_HUMAN 143 1 -
VRLALVNWLFAR SYE_AZOBR 20 1 -
ARAAVLNDYFVK SYE_METJA 109 1 -
ARTALFNYLFAR SYE_BACSU 22 1 -
ARTALYSWLFAR SYE_ECOLI 20 1 -
ARTALFNYLLAK SYE_MYCPU 21 1 -
ARTALFNYLFAR SYE_BACST 22 1 -
ARTAVFNWLFAR SYE_SYNY3 20 1 -
ARTALYSWLYAK SYE_HAEIN 32 1 -
ARTALFNYLYAR SYE_TOBAC 73 1 -
LRTAIFNYLFAR SYE_HELPY 21 1 -
ARTAIFNFLLAK SYE_MYCPN 21 1 -
ARAAILNHEYAR SYE_METTH 113 1 -

Motif 3 width=14
Element Seqn Id St Int Rpt
GNFLLRLDDTDEER SYE_AZOBR 35 3 -
GKYIIRFDDTDPRT D69282 126 3 -
KPFLIRIEDTDKER C64600 32 3 -
GKFIIRVEDTDKKR SYE_BACSU 37 3 -
GEFVLRIEDTDLER SYE_ECOLI 35 3 -
GDFIIRIEDTDVKR SYE_MYCPU 36 3 -
GKMIVRIEDTDIER SYE_BACST 37 3 -
GTFILRVEDTDLER SYE_SYNY3 35 3 -
GEFVLRIEDTDLER SYE_HAEIN 47 3 -
GKFILRIEDTDLER SYE_TOBAC 88 3 -
GKFFLRIEDTDLSR SYE_HELPY 36 3 -
GEFIIRIEDTDTER SYE_MYCPN 36 3 -
GKFILRIEDTDATR SYE_RHIME 38 3 -
GKLILRIEDTDPRR SYE_METTH 128 3 -
GKFILRFDDTDPKV SYE_SULSO 134 3 -
GRFIVRIEDTDRAR SYE_THETH 34 3 -
GKLILRLEDTDPKR SYE_METJA 124 3 -
GKLIMRFDDTNPEK SYEP_HUMAN 158 3 -

Motif 4 width=11
Element Seqn Id St Int Rpt
PLYTLTSVVDD SYE_AZOBR 182 133 -
PTYDFACPIVD SYEP_HUMAN 303 131 -
PTLDFESAIED D69282 273 133 -
PTYNFAVAIDD SYE_BACSU 194 143 -
PTYNFCVVVDD SYE_ECOLI 179 130 -
PTYNFACACDD C64600 172 126 -
PTYNFAVVIDD SYE_MYCPU 194 144 -
PTYNFAVVIDD SYE_BACST 195 144 -
PLYNLAVVVDD SYE_SYNY3 192 143 -
PTYNFCVVVDD SYE_HAEIN 190 129 -
PVYNFCVTVDD SYE_TOBAC 245 143 -
PTYNFVVTIDD SYE_HELPY 180 130 -
ATYNFAVVIDD SYE_MYCPN 193 143 -
PTYHMANVVDD SYE_RHIME 195 143 -
PMMNFSVAVDD SYE_METTH 271 129 -
PTYNFASIIDD SYE_SULSO 289 141 -
PTYHLANVVDD SYE_THETH 185 137 -
PLMNFSVPVDD SYE_METJA 267 129 -

Motif 5 width=9
Element Seqn Id St Int Rpt
TDVIRAEEW SYE_THETH 201 5 -
THVIRGEDH SYE_AZOBR 198 5 -
THALRTTEY SYEP_HUMAN 319 5 -
THVLRGEDH SYE_BACSU 210 5 -
SLIIRGEDH C64600 188 5 -
THIIRGKDL D69282 289 5 -
THVIRGEDH SYE_ECOLI 195 5 -
SHILRGEEH SYE_MYCPU 210 5 -
SHVFRGEEH SYE_BACST 211 5 -
THVIRGEDH SYE_SYNY3 208 5 -
THVVRGEDH SYE_HAEIN 206 5 -
SHVIRAEEH SYE_TOBAC 261 5 -
TDVIRGDDH SYE_HELPY 196 5 -
TDVLRGAEH SYE_MYCPN 209 5 -
THVARGEEW SYE_RHIME 211 5 -
THVLRGKDH SYE_METTH 287 5 -
THVLRAKEH SYE_SULSO 305 5 -
THVLRGKDH SYE_METJA 283 5 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
RYAPSPTGHLHIG SYE_BACSU 8 8 -
RFAPSPTGYLHLG O67271 7 7 -
RFAPSPTGYLHVG SYE_ECOLI 6 6 -
RYAPSPTGYLHIG SYE_MYCPU 7 7 -
GYAPSPTGHLHIG SYE_BACST 8 8 -
RIAPSPTGNLHIG SYE_SYNY3 6 6 -
RYAPSPTGHLHIG SYE_LACDE 9 9 -
RFAPSPTGYLHVG SYE_HAEIN 18 18 -
RFAPSPTGNLHVG SYE_TOBAC 59 59 -
RFAPSPTGNLHVG SYE_HORVU 47 47 -
RFAPSPTGYLHIG SYE_HELPY 7 7 -
RVAPSPTGDPHVG P94662 9 9 -
RVAPSPTGDPHVG O84451 9 9 -
RYAPSPTGYLHVG SYE_MYCPN 7 7 -
RIAPSPTGEPHVG SYE_RHIME 9 9 -
RFAPSPTGFLHLG SYEM_YEAST 48 48 -
RFAPSPTGHLHIG O44413 14 14 -
RYAPSPTGLQHIG O51345 6 6 -
RYAPSPTGYLHVG SYE_MYCGE 7 7 -
RYAPSPTGLQHIG SYE_TREPA 6 6 -
RFAPNPSGPLHIG SYE_METTM 99 99 -
RFAPNPSGPLHIG SYE_METTH 99 99 -
RFCPSPTGNPHVG O86528 12 12 -
RFCPSPTGVPHVG O33120 18 18 -
RFAPNPDGPLHLG SYE_SULSO 105 105 -
RIAPSPTGDPHVG SYE_THETH 5 5 -
RFAPNPSGPLHIG SYE_METJA 95 95 -
RFCPSPTGTPHVG O53241 10 10 -
RFAPSPTGLLHVG SYE_AZOBR 6 6 -
RFAPNPDGAFHLG O59314 102 102 -
RFAPSPTGDMHIG O25360 3 3 -
RFPPEPSGYLHIG O13775 210 210 -
RFPPEPSGYLHIG SYEC_YEAST 221 221 -
RFAPEPSGYLHIG O65253 226 226 -
RFAPEPSGYLHIG O82462 217 217 -
RFPPEASGYLHIG SYEP_DROME 207 207 -
RFPPEASGYLHIG SYEP_HUMAN 129 129 -
RFPPEASGYLHIG Q23315 197 197 -
RFAPSPSGELHFG YADB_ECOLI 19 19 -
RFAPNPNGPPTLG SYE_ARCFU 97 97 -

Motif 2 width=12
Element Seqn Id St Int Rpt
ARTALFNYLFAR SYE_BACSU 22 1 -
ARTAIFSYLFAR O67271 21 1 -
ARTALYSWLFAR SYE_ECOLI 20 1 -
ARTALFNYLLAK SYE_MYCPU 21 1 -
ARTALFNYLFAR SYE_BACST 22 1 -
ARTAVFNWLFAR SYE_SYNY3 20 1 -
ARTALFNYLFAR SYE_LACDE 23 1 -
ARTALYSWLYAK SYE_HAEIN 32 1 -
ARTALFNYLYAR SYE_TOBAC 73 1 -
ARTALFNYLFAR SYE_HORVU 61 1 -
LRTAIFNYLFAR SYE_HELPY 21 1 -
AYMALFNEIFAK P94662 23 1 -
AYMALFNEVFAR O84451 23 1 -
ARTAIFNFLLAK SYE_MYCPN 21 1 -
AYIALFNYLFAK SYE_RHIME 23 1 -
LRTALYNYLLAR SYEM_YEAST 62 1 -
LRTAFFNYLFAK O44413 28 1 -
IRTALFNYFFAK O51345 20 1 -
TRTAIFNFLLAK SYE_MYCGE 21 1 -
IRTALFNFLFAR SYE_TREPA 20 1 -
ARAAILNHEYAR SYE_METTM 113 1 -
ARAAILNHEYAR SYE_METTH 113 1 -
VRTALFNWAFAR O86528 26 1 -
VRTALFNWAYAR O33120 32 1 -
ARSAILSYEYAK SYE_SULSO 119 1 -
AYIALFNYAWAR SYE_THETH 19 1 -
ARAAVLNDYFVK SYE_METJA 109 1 -
VRTALFNWAYAR O53241 24 1 -
VRLALVNWLFAR SYE_AZOBR 20 1 -
ARAAILSYEYAK O59314 116 1 -
LRAAIFNYIVAK O25360 17 1 -
AKAALLNQYFAN O13775 224 1 -
AKAALLNQYFAQ SYEC_YEAST 235 1 -
AKAALLNKYFAE O65253 240 1 -
AKAALLNKYFAE O82462 231 1 -
AKAALLNQYYAL SYEP_DROME 221 1 -
AKAALLNQHYQV SYEP_HUMAN 143 1 -
AKAALLNQYYQQ Q23315 211 1 -
LIAALGSYLQAR YADB_ECOLI 33 1 -
ARGIIVNGEYAK SYE_ARCFU 111 1 -

Motif 3 width=14
Element Seqn Id St Int Rpt
GKFIIRVEDTDKKR SYE_BACSU 37 3 -
GGFVLRIEDTDPER O67271 36 3 -
GEFVLRIEDTDLER SYE_ECOLI 35 3 -
GDFIIRIEDTDVKR SYE_MYCPU 36 3 -
GKMIVRIEDTDIER SYE_BACST 37 3 -
GTFILRVEDTDLER SYE_SYNY3 35 3 -
GTLVLRIEDADTER SYE_LACDE 38 3 -
GEFVLRIEDTDLER SYE_HAEIN 47 3 -
GKFILRIEDTDLER SYE_TOBAC 88 3 -
GKFVLRVEDTDLER SYE_HORVU 76 3 -
GKFFLRIEDTDLSR SYE_HELPY 36 3 -
GKMILRIEDTDQTR P94662 38 3 -
GQMILRIEDTDQTR O84451 38 3 -
GEFIIRIEDTDTER SYE_MYCPN 36 3 -
GKFILRIEDTDATR SYE_RHIME 38 3 -
GQFLLRLEDTDQKR SYEM_YEAST 77 3 -
GDFILRIEDTDRTR O44413 43 3 -
GKFLLRIEDTDQSR O51345 35 3 -
GEFIIRIEDTDTER SYE_MYCGE 36 3 -
GVFVLRVEDTDRSR SYE_TREPA 35 3 -
GKLILRIEDTDPRR SYE_METTM 128 3 -
GKLILRIEDTDPRR SYE_METTH 128 3 -
GTLVFRIEDTDAAR O86528 41 3 -
GTFVLRIEDTDADR O33120 47 3 -
GKFILRFDDTDPKV SYE_SULSO 134 3 -
GRFIVRIEDTDRAR SYE_THETH 34 3 -
GKLILRLEDTDPKR SYE_METJA 124 3 -
GTFVFRIEDTDAQR O53241 39 3 -
GNFLLRLDDTDEER SYE_AZOBR 35 3 -
GKFILRFDDTDPKV O59314 131 3 -
KPFLIRIEDTDKER O25360 32 3 -
GKLIVRFDDTNPSK O13775 239 3 -
GKLIIRFDDTNPSK SYEC_YEAST 250 3 -
GEVIVRFDDTNPAK O65253 255 3 -
GEVIVRFDDTNPAK O82462 246 3 -
GTLIMRFDDTNPAK SYEP_DROME 236 3 -
GKLIMRFDDTNPEK SYEP_HUMAN 158 3 -
GQLIMRFDDTNPAK Q23315 226 3 -
GRWLVRIEDIDPPR YADB_ECOLI 48 3 -
GKYIIRFDDTDPRT SYE_ARCFU 126 3 -

Motif 4 width=11
Element Seqn Id St Int Rpt
PTYNFAVAIDD SYE_BACSU 194 143 -
PTYNFVVVVDD O67271 184 134 -
PTYNFCVVVDD SYE_ECOLI 179 130 -
PTYNFAVVIDD SYE_MYCPU 194 144 -
PTYNFAVVIDD SYE_BACST 195 144 -
PLYNLAVVVDD SYE_SYNY3 192 143 -
PTYNFAVVIDD SYE_LACDE 200 148 -
PTYNFCVVVDD SYE_HAEIN 190 129 -
PVYNFCVTVDD SYE_TOBAC 245 143 -
PVYNFCVTVDD SYE_HORVU 233 143 -
PTYNFVVTIDD SYE_HELPY 180 130 -
PTYHFANVVDD P94662 195 143 -
PTYHFANVVDD O84451 195 143 -
ATYNFAVVIDD SYE_MYCPN 193 143 -
PTYHMANVVDD SYE_RHIME 195 143 -
PTYHLANVVDD SYEM_YEAST 233 142 -
PTYHLANVIDD O44413 191 134 -
PTYHLANVVDD O51345 193 144 -
ATYNFAVVIDD SYE_MYCGE 193 143 -
PTYHLANVVDD SYE_TREPA 212 163 -
PMMNFSVAVDD SYE_METTM 271 129 -
PMMNFSVAVDD SYE_METTH 271 129 -
PLYTLVNPVDD O86528 197 142 -
PLYTLVNPCDD O33120 202 141 -
PTYNFASIIDD SYE_SULSO 289 141 -
PTYHLANVVDD SYE_THETH 185 137 -
PLMNFSVPVDD SYE_METJA 267 129 -
PLYTLVNPCDD O53241 194 141 -
PLYTLTSVVDD SYE_AZOBR 182 133 -
PLYNFASAIDD O59314 279 134 -
PTYNFACACDD O25360 172 126 -
PTYDFACPIVD O13775 384 131 -
PTYDFCVPIVD SYEC_YEAST 396 132 -
PTYDFACPFVD O65253 400 131 -
PTYDFACPFVD O82462 391 131 -
PTYDFACPIVD SYEP_DROME 381 131 -
PTYDFACPIVD SYEP_HUMAN 303 131 -
PTYDFTCPIVD Q23315 371 131 -
FAYNLAVVVDD YADB_ECOLI 180 118 -
PTLDFESAIED SYE_ARCFU 273 133 -

Motif 5 width=9
Element Seqn Id St Int Rpt
THVLRGEDH SYE_BACSU 210 5 -
THVIRGEDH O67271 200 5 -
THVIRGEDH SYE_ECOLI 195 5 -
SHILRGEEH SYE_MYCPU 210 5 -
SHVFRGEEH SYE_BACST 211 5 -
THVIRGEDH SYE_SYNY3 208 5 -
SHVLRGDDH SYE_LACDE 216 5 -
THVVRGEDH SYE_HAEIN 206 5 -
SHVIRAEEH SYE_TOBAC 261 5 -
SHVIRAEEH SYE_HORVU 249 5 -
TDVIRGDDH SYE_HELPY 196 5 -
THVLRGEEW P94662 211 5 -
THVLRGEEW O84451 211 5 -
TDVLRGAEH SYE_MYCPN 209 5 -
THVARGEEW SYE_RHIME 211 5 -
THVIRGEEW SYEM_YEAST 249 5 -
SHVIRGMEW O44413 207 5 -
THVLRAQEW O51345 209 5 -
TDVLRGAEH SYE_MYCGE 209 5 -
THVLRAQEW SYE_TREPA 228 5 -
THVLRGKDH SYE_METTM 287 5 -
THVLRGKDH SYE_METTH 287 5 -
THVLRGEDL O86528 213 5 -
THVLRGEDL O33120 218 5 -
THVLRAKEH SYE_SULSO 305 5 -
TDVIRAEEW SYE_THETH 201 5 -
THVLRGKDH SYE_METJA 283 5 -
THVLRGEDL O53241 210 5 -
THVIRGEDH SYE_AZOBR 198 5 -
THIFRGQEH O59314 295 5 -
SLIIRGEDH O25360 188 5 -
THALRTTEY O13775 400 5 -
THALRTIEY SYEC_YEAST 412 5 -
THALRSSEY O65253 416 5 -
THALRSSEY O82462 407 5 -
THTLRTTEY SYEP_DROME 397 5 -
THALRTTEY SYEP_HUMAN 319 5 -
THALRTTEY Q23315 387 5 -
TEIVRGADL YADB_ECOLI 196 5 -
THIIRGKDL SYE_ARCFU 289 5 -