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PR00853

Identifier
XPGRADSUPER  [View Relations]  [View Alignment]  
Accession
PR00853
No. of Motifs
5
Creation Date
08-MAR-1998  (UPDATE 27-JUN-1999)
Title
Xeroderma pigmentosum group G/yeast RAD superfamily signature
Database References
PRINTS; PR00066 XRODRMPGMNTG
PROSITE; PS00841 XPG_1; PS00842 XPG_2
PFAM; PF00752 XPG_N; PF00867 XPG_I
INTERPRO; IPR001532
Literature References
1. TANAKA, K. AND WOOD, R.D.
Xeroderma pigmentosum and nucleotide excision-repair of DNA.
TRENDS BIOCHEM.SCI. 19 83-86 (1994).
 
2. SCHERLY, D., NOUSPIKEL, T., CORLET, J., UCLA, C., BAIROCH, A.
AND CLARKSON, S.G.
Complementation of the DNA repair defect in xeroderma pigmentosum
group G cells by a human cDNA related to yeast RAD2.
NATURE 363 182-185 (1993).
 
3. CARR, A.M., SHELDRICK, K.S., MURRAY, J.M., AL-HARITHY, R., WATTS, F.Z.
AND LEHMANN, A.R.
Evolutionary conservation of excision repair in Schizosaccharomyces pombe - 
evidence for a family of sequences related to the Saccharomyces cerevisiae
rad2 gene.
NUCLEIC ACIDS RES. 21 1345-1349 (1993). 
 
4. O'DONOVAN, A., SCHERLY, D., CLARKSON, S.G. AND WOOD, R.D.
Isolation of active recombinant XPG protein, a human DNA repair
endonuclease.
J.BIOL.CHEM. 269 15965-15968 (1994).
 
5. O'DONOVAN, A., DAVIES, A.A., MOGGS, J.G., WEST, S.C. AND WOOD, R.D.
XPG endonuclease makes the 3' incision in human DNA nucleotide excision
repair.
NATURE 371 432-435 (1994).
 
6. HABRAKEN, Y., SUNG, P., PRAKASH, L. AND PRAKASH, S.
Yeast excision repair gene RAD2 encodes a single-stranded DNA endonuclease.
NATURE 366 365-368 (1993).

Documentation
Defects in DNA repair proteins can give rise, in humans, to the autosomal
recessive disorders xeroderma pigmentosum (XP) and Cockayne's syndrome [1,2].
XP is characterised by a high incidence of sunlight-induced skin cancer,
the effect of skin-cell hypersensitivity to UV resulting from defects in
the nucleotide excision pathway. Seven XP complementation groups have
been identified: XP-A to XP-G. 
 
XP-G is one of the most rare and phenotypically heterogeneous of XP, showing
anything from slight to extreme dysfunction in DNA excision repair [3,4].
XP-G can be corrected by a 133 Kd nuclear protein, XPGC [1]. XPGC is an 
acidic protein that confers normal UV resistance in expressing cells [4].
It is a magnesium-dependent, single-strand DNA endonuclease that makes
structure-specific endonucleolytic incisions in a DNA substrate containing
a duplex region and single-stranded arms [4,5]. XPGC cleaves one strand of
the duplex at the border with the single-stranded region [5].
 
XPG belongs to a family of proteins that includes RAD2 from budding yeast
and rad13 from fission yeast, which are single-stranded DNA endonucleases
[5,6]; mouse and human FEN-1, a structure-specific endonuclease; RAD2 from 
fission yeast and RAD27 from budding yeast; fission yeast exo1, a 5'->3'
double-stranded DNA exonuclease that may act in a pathway that corrects
mismatched base pairs; yeast DHS1, and yeast DIN7.
 
Sequence analysis reveals that similarities within the family are largely
confined to two well-conserved domains, the first of which is located at
the N-terminal extremity (the N-region), the second lying towards the 
C-terminus (the I-region). The I-region contains a perfectly conserved
hexapeptide, EAEAQC, the Glu and Cys residues of which may be involved in
the excision repair mechanism.
 
XPGRADSUPER is a 5-element fingerprint that provides a signature for the
XPG/RAD superfamily. The fingerprint was derived from an initial alignment
of 17 sequences: the motifs were drawn from short conserved regions within 
the N- and C-terminal portions of the alignment - motifs 1 and 2 lie within
the N-domain, motif 2 including the region encoded by PROSITE pattern XPG_1
(PS00841); and motifs 3-5 lie in the I domain, motif 3 including the region
encoded by PROSITE pattern XPG_2 (PS00842), which contains a putative
catalytic core pentapeptide. Two iterations on OWL30.0 were required to 
reach convergence, at which point a true set comprising 23 sequences was
identified. Several partial matches were also found: CELT12A25 is a
C.elegans sequence that fails to match the first 2 motifs; and YA31_SCHPO,
YEN1_YEAST and SCU13615 are yeast proteins that match only 2 motifs.
 
An update on SPTR37_9f identified a true set of 32 sequences, and 2
partial matches.
Summary Information
  32 codes involving  5 elements
0 codes involving 4 elements
0 codes involving 3 elements
2 codes involving 2 elements
Composite Feature Index
53232323232
400000
300000
200220
12345
True Positives
DIN7_YEAST    EXO1_SCHPO    EXO1_YEAST    FEN1_HUMAN    
FEN1_MOUSE O27670 O29975 O44737
O50123 O57351 O59728 O60545
O62245 O65251 O75214 O75466
P70040 P70054 Q22418 Q24557
Q24558 Q58839 Q61528 Q64248
RA13_SCHPO RA27_YEAST RAD2_SCHPO RAD2_YEAST
XPG_HUMAN XPG_MOUSE XPG_XENLA YA31_SCHPO
True Positive Partials
Codes involving 2 elements
Q02463 YEN1_YEAST
Sequence Titles
DIN7_YEAST  DNA-DAMAGE INDUCIBLE PROTEIN DIN7 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). 
EXO1_SCHPO EXONUCLEASE I (EXO I) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
EXO1_YEAST EXONUCLEASE I (EXO I) (DHS1 PROTEIN) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
FEN1_HUMAN FLAP ENDONUCLEASE-1 (MATURATION FACTOR 1) (MF1) - HOMO SAPIENS (HUMAN).
FEN1_MOUSE FLAP ENDONUCLEASE-1 - MUS MUSCULUS (MOUSE).
O27670 DNA REPAIR PROTEIN RAD2 - METHANOBACTERIUM THERMOAUTOTROPHICUM.
O29975 DNA REPAIR PROTEIN RAD2 (RAD2) - ARCHAEOGLOBUS FULGIDUS.
O44737 F57B10.6 PROTEIN - CAENORHABDITIS ELEGANS.
O50123 343AA LONG HYPOTHETICAL 5' NUCLEASE - PYROCOCCUS HORIKOSHII.
O57351 FLAP ENDONUCLEASE 1 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O59728 DNA REPAIR PROTEIN RAD13 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O60545 PUTATIVE 5'-3' EXONUCLEASE HEX1 - HOMO SAPIENS (HUMAN).
O62245 F45G2.3 PROTEIN - CAENORHABDITIS ELEGANS.
O65251 F21E10.3 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O75214 HEX1 - HOMO SAPIENS (HUMAN).
O75466 EXONUCLEASE I - HOMO SAPIENS (HUMAN).
P70040 5' NUCLEASE XFEN1A - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
P70054 XFEN1B - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q22418 SIMILAR TO S. CEREVISIAE DNA REPAIR PROTEIN RAD2 - CAENORHABDITIS ELEGANS.
Q24557 TOSCA - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q24558 TOSCA - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q58839 HYPOTHETICAL PROTEIN MJ1444 - METHANOCOCCUS JANNASCHII.
Q61528 DNA-REPAIR PROTEIN COMPLEMENTING XP-G CELLS HOMOLOG (XERODERMA PIGMENTOSUM GROUP G COMPLEMENTING PROTEIN HOMOLOG) (DNA EXCISION REPAIR PROTEIN ERCC-5) - MUS MUSCULUS (MOUSE).
Q64248 DNA-REPAIR PROTEIN COMPLEMENTING XP-G CELLS HOMOLOG (XERODERMA PIGMENTOSUM GROUP G COMPLEMENTING PROTEIN HOMOLOG) (DNA EXCISION REPAIR PROTEIN ERCC-5) - MUS MUSCULUS (MOUSE).
RA13_SCHPO DNA REPAIR PROTEIN RAD13 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
RA27_YEAST STRUCTURE SPECIFIC ENDONUCLEASE RAD27 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
RAD2_SCHPO DNA REPAIR PROTEIN RAD2 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
RAD2_YEAST DNA REPAIR PROTEIN RAD2 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
XPG_HUMAN DNA-REPAIR PROTEIN COMPLEMENTING XP-G CELLS (XERODERMA PIGMENTOSUM GROUP G COMPLEMENTING PROTEIN) (DNA EXCISION REPAIR PROTEIN ERCC-5) - HOMO SAPIENS (HUMAN).
XPG_MOUSE DNA-REPAIR PROTEIN COMPLEMENTING XP-G CELLS HOMOLOG (XERODERMA PIGMENTOSUM GROUP G COMPLEMENTING PROTEIN HOMOLOG) (DNA EXCISION REPAIR PROTEIN ERCC-5) - MUS MUSCULUS (MOUSE).
XPG_XENLA DNA-REPAIR PROTEIN COMPLEMENTING XP-G CELLS HOMOLOG (XERODERMA PIGMENTOSUM GROUP G COMPLEMENTING PROTEIN HOMOLOG) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
YA31_SCHPO HYPOTHETICAL 57.8 KD PROTEIN C18B11.01C IN CHROMOSOME I - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).

Q02463 UNKNOWN ORF 3' TO GLN3 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
YEN1_YEAST HYPOTHETICAL 87.4 KD PROTEIN IN GLN3-SAH1 INTERGENIC REGION - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
Scan History
OWL30_0    2  50   NSINGLE    
SPTR37_9f 4 34 NSINGLE
Initial Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
GRKVAIDASMSLYQF RA27_YEAST 28 28 -
GRKVAIDASMSLYQF RAD2_SCHPO 28 28 -
GKILAVDISIWLNQA XPG_XENLA 24 24 -
GKILAVDISIWLNQA XPG_HUMAN 24 24 -
GKVLAVDISIWLNQA XPG_MOUSE 24 24 -
GRKVAIDASMSIYQF FEN1_HUMAN 28 28 -
GKILAVDISIWLNQA I58009 24 24 -
GKVLAVDISIWLNQA A57650 24 24 -
GKVLAVDISIWLNQA MMU40796 24 24 -
GRKVAVDASMCIYQF XLU68141 28 28 -
GKILAVDISIWLNQA A54439 24 24 -
GKKVAIDGMNALYQF C64480 21 21 -
YQTLAIDGYAWLHRA DIN7_YEAST 24 24 -
GEVLAIDGYAWLHRA EXO1_YEAST 24 24 -
GKTLGVDGYVWLHKA EXO1_SCHPO 24 24 -
DKRMAVDASIWIYQF RAD2_YEAST 24 24 -
NKRLAIDASIWIYQF RA13_SCHPO 24 24 -

Motif 2 width=20
Element Seqn Id St Int Rpt
PVYVFDGKPPQMKSGELAKR XLU68141 81 38 -
PIFVFDGDAPLLKKQTLVKR A54439 72 33 -
PIFVFDGDAPLLKKQTLVKR I58009 72 33 -
PIFVFDGDAPLLKKQTLAKR A57650 72 33 -
PIFVFDGDAPLLKKQTLAKR MMU40796 72 33 -
PIWVFDGEPPKLKEKTRKVR C64480 75 39 -
PVYVFDGKPPQLKSGELAKR FEN1_HUMAN 81 38 -
PIFVFDGDAPLLKKQTLAKR XPG_MOUSE 72 33 -
PIFVFDGDAPLLKKQTLVKR XPG_HUMAN 72 33 -
PIFVFDGEAPLLKRQTLAKR XPG_XENLA 72 33 -
PCFVFDGKPPTLKSGELAKR RAD2_SCHPO 82 39 -
PCYVFDGKPPDLKSHELTKR RA27_YEAST 82 39 -
PVFVFDGGAPSLKRQTIQKR RA13_SCHPO 72 33 -
PVFVFDGGVPVLKRETIRQR RAD2_YEAST 72 33 -
PLIVFDGGPLPCKASTEQKR EXO1_SCHPO 73 34 -
PYLVFDGDAIPVKKSTESKR EXO1_YEAST 73 34 -
PYIVFDGDSLFVKNHTETRR DIN7_YEAST 73 34 -

Motif 3 width=18
Element Seqn Id St Int Rpt
LSLMGIPYLDAPSEAEAS FEN1_HUMAN 145 44 -
LSLMGIPYVEAPSEGEAQ C64480 139 44 -
LSLMGIPYVDAPCEAEAT XLU68141 145 44 -
LRLFGVPYIQAPMEAEAQ MMU40796 775 683 -
LRLFGVPYIQAPMEAEAQ A57650 775 683 -
LRLFGIPYIQAPMEAEAQ I58009 776 684 -
LRLFGIPYIQAPMEAEAQ A54439 776 684 -
CKLHSIPYIVAPFEADPQ DIN7_YEAST 137 44 -
CKLNGIRYIVAPFEADSQ EXO1_YEAST 137 44 -
LREHGIESIVAPYEADAQ EXO1_SCHPO 137 44 -
LSRFGIPYITAPMEAEAQ RAD2_YEAST 779 687 -
LRLFGLPYIVAPQEAEAQ RA13_SCHPO 765 673 -
LGLMGIPYIIAPTEAEAQ RA27_YEAST 143 41 -
LELMGIPFVNAPCEAEAQ RAD2_SCHPO 146 44 -
LQLFGIPYIVAPMEAEAQ XPG_XENLA 809 717 -
LRLFGIPYIQAPMEAEAQ XPG_HUMAN 776 684 -
LRLFGVPYIQAPMEAEAQ XPG_MOUSE 789 697 -

Motif 4 width=21
Element Seqn Id St Int Rpt
LEQKNIVQGIISEDSDLLVFG EXO1_YEAST 158 3 -
LVKAGKVYAAATEDMDCLTFG FEN1_HUMAN 166 3 -
LDLSDQTSGTITDDSDIWLFG XPG_MOUSE 810 3 -
LDLTDQTSGTITDDSDIWLFG XPG_HUMAN 797 3 -
LDLTDQTSGTITDDSDIWLFG XPG_XENLA 830 3 -
LARSGKVYAAASEDMDTLCFQ RAD2_SCHPO 167 3 -
LAKKGKVYAAASEDMDTLCYR RA27_YEAST 164 3 -
LLELKLVDGIVTDDSDVFLFG RA13_SCHPO 786 3 -
LLQLNLVDGIITDDSDVFLFG RAD2_YEAST 800 3 -
LEKENIIDGIITEDSDMLVFG EXO1_SCHPO 158 3 -
LDLTDQTSGTITDDSDIWLFG A54439 797 3 -
LEKMGLIQGIISEDSDLLVFG DIN7_YEAST 158 3 -
MAKKGDVWAVVSQDYDALLYG C64480 160 3 -
LVKAGKVYAAATEDMDALTFG XLU68141 166 3 -
LDLSDQTSGTITDDSDIWLFG MMU40796 796 3 -
LDLSDQTSGTITDDSDIWLFG A57650 796 3 -
LDLTDQTSGTITDDSDIWLFG I58009 797 3 -

Motif 5 width=16
Element Seqn Id St Int Rpt
LIDIAIFMGTDYNPGG C64480 214 33 -
FRNLVCLAGCDYTSGI DIN7_YEAST 217 38 -
IITMVCLSGCDYTNGI EXO1_YEAST 217 38 -
LRHMAIFSGCDYTDGV EXO1_SCHPO 215 36 -
MIELAQLLGSDYTNGL RAD2_YEAST 854 33 -
LIKLAHLLGSDYTMGL RA13_SCHPO 840 33 -
FVDLCIMLGCDYCESI RA27_YEAST 221 36 -
FVDLCILLGCDYCEPI RAD2_SCHPO 224 36 -
LINLAYLLGSDYTEGI XPG_XENLA 884 33 -
LINLAYLLGSDYTEGI XPG_HUMAN 851 33 -
LINLAYLLGSDYTEGI XPG_MOUSE 864 33 -
FVDLCILLGSDYCESI FEN1_HUMAN 223 36 -
LINLAYLLGSDYTEGI A54439 851 33 -
LINLAYLLGSDYTGNT I58009 851 33 -
LINLAYLLGSDYTEGI A57650 850 33 -
LINLAYLLGSDYTEGI MMU40796 850 33 -
FVDLCILLGSDYCETI XLU68141 223 36 -
Final Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
GRKVAIDASMSIYQF FEN1_HUMAN 28 28 -
GRKVAIDASMSIYQF FEN1_MOUSE 28 28 -
GRKVAVDASMCIYQF P70054 28 28 -
GRKVAVDASMCIYQF P70040 28 28 -
GKVLAVDISIWLNQA Q61528 24 24 -
GKVLAVDISIWLNQA Q64248 24 24 -
GKVLAVDISIWLNQA XPG_MOUSE 24 24 -
GRKVAIDASMCIYQF O57351 28 28 -
GKILAVDISIWLNQA XPG_HUMAN 24 24 -
GKILAVDISIWLNQA XPG_XENLA 24 24 -
GRKVAIDASMSLYQF RAD2_SCHPO 28 28 -
GRKIAVDASMSIYQF O65251 28 28 -
GRKVAIDASMSLYQF RA27_YEAST 28 28 -
NKRLAIDASIWIYQF O59728 24 24 -
NKRLAIDASIWIYQF RA13_SCHPO 24 24 -
DKRMAVDASIWIYQF RAD2_YEAST 24 24 -
GKKIAIDALNAIYQF O50123 21 21 -
GQVVAVDTYCWLHKG O60545 24 24 -
GQVVAVDTYCWLHKG O75214 24 24 -
GQVVAVDTYCWLHKG O75466 24 24 -
GKKIAVDAFNTLYQF O29975 21 21 -
GKKVAIDGMNALYQF Q58839 21 21 -
GKTLGVDGYVWLHKA EXO1_SCHPO 24 24 -
GSTVAVDTYCWLHKG Q24557 24 24 -
GSTVAVDTYCWLHKG Q24558 24 24 -
GEVLAIDGYAWLHRA EXO1_YEAST 24 24 -
GRTVAVDAANTLYQF O27670 21 21 -
YQTLAIDGYAWLHRA DIN7_YEAST 24 24 -
GKKLAIDVSIWIYQA O44737 24 24 -
GKSVAIDVSCLLHRG O62245 672 672 -
DKTLSIDGHIWLYES Q22418 24 24 -
YPVLAVDGNLLLYRF YA31_SCHPO 30 30 -

Motif 2 width=20
Element Seqn Id St Int Rpt
PVYVFDGKPPQLKSGELAKR FEN1_HUMAN 81 38 -
PVYVFDGKPPQLKSGELAKR FEN1_MOUSE 79 36 -
PVYVFDGKPPQMKSGELAKR P70054 81 38 -
PVYVFDGKPPQMKSGELAKR P70040 81 38 -
PIFVFDGDAPLLKKQTLAKR Q61528 72 33 -
PIFVFDGDAPLLKKQTLAKR Q64248 72 33 -
PIFVFDGDAPLLKKQTLAKR XPG_MOUSE 72 33 -
PVYVFDGKPPQMKSGELAKR O57351 81 38 -
PIFVFDGDAPLLKKQTLVKR XPG_HUMAN 72 33 -
PIFVFDGEAPLLKRQTLAKR XPG_XENLA 72 33 -
PCFVFDGKPPTLKSGELAKR RAD2_SCHPO 82 39 -
PVYVFDGKPPELKRQELAKR O65251 115 72 -
PCYVFDGKPPDLKSHELTKR RA27_YEAST 82 39 -
PVFVFDGGAPSLKRQTIQKR O59728 72 33 -
PVFVFDGGAPSLKRQTIQKR RA13_SCHPO 72 33 -
PVFVFDGGVPVLKRETIRQR RAD2_YEAST 72 33 -
PAYVFDGKPPEFKRKELEKR O50123 75 39 -
PILVFDGCTLPSKKEVERSR O60545 73 34 -
PILVFDGCTLPSKKEVERSR O75214 73 34 -
PILVFDGCTLPSKKEVERSR O75466 73 34 -
PVFVFDGEPPEFKKAEIEER O29975 75 39 -
PIWVFDGEPPKLKEKTRKVR Q58839 75 39 -
PLIVFDGGPLPCKASTEQKR EXO1_SCHPO 73 34 -
PILVFDGQHLPAKALTEKRR Q24557 73 34 -
PILVFDGQHLPAKALTEKRR Q24558 73 34 -
PYLVFDGDAIPVKKSTESKR EXO1_YEAST 73 34 -
VIYVFDGRSHHLKGETVSRR O27670 75 39 -
PYIVFDGDSLFVKNHTETRR DIN7_YEAST 73 34 -
PVFVFDGPQVPPLKRQVLEA O44737 68 29 -
VVMVFDGRPLPAKKGTNEER O62245 721 34 -
PIVVFDNINASSSAHESKDQ Q22418 71 32 -
PIVVFDNLKPNDFKAEEHEK YA31_SCHPO 76 31 -

Motif 3 width=18
Element Seqn Id St Int Rpt
LSLMGIPYLDAPSEAEAS FEN1_HUMAN 145 44 -
LSLMGIPYLDAPSEAEAS FEN1_MOUSE 143 44 -
LSLMGIPYVDAPCEAEAT P70054 145 44 -
LTLMGIPYVDAPCEAEAT P70040 145 44 -
LRLFGVPYIQAPMEAEAQ Q61528 775 683 -
LRLFGVPYIQAPMEAEAQ Q64248 775 683 -
LRLFGVPYIQAPMEAEAQ XPG_MOUSE 789 697 -
LTLMGIPYVDAPCEAEAT O57351 145 44 -
LRLFGIPYIQAPMEAEAQ XPG_HUMAN 776 684 -
LQLFGIPYIVAPMEAEAQ XPG_XENLA 809 717 -
LELMGIPFVNAPCEAEAQ RAD2_SCHPO 146 44 -
LRLMGVPVVEATSEAEAQ O65251 179 44 -
LGLMGIPYIIAPTEAEAQ RA27_YEAST 143 41 -
LRLFGLPYIVAPQEAEAQ O59728 764 672 -
LRLFGLPYIVAPQEAEAQ RA13_SCHPO 765 673 -
LSRFGIPYITAPMEAEAQ RAD2_YEAST 779 687 -
LQLMGIPIIQAPSEGEAQ O50123 139 44 -
ARSQGVDCLVAPYEADAQ O60545 137 44 -
ARSQGVDCLVAPYEADAQ O75214 137 44 -
ARSQGVDCLVAPYEADAQ O75466 137 44 -
LSYMGIPFVDAPSEGEAQ O29975 138 43 -
LSLMGIPYVEAPSEGEAQ Q58839 139 44 -
LREHGIESIVAPYEADAQ EXO1_SCHPO 137 44 -
CRSRNVDCIVAPYEADAQ Q24557 137 44 -
CRSRNVDCIVAPYEADAQ Q24558 137 44 -
CKLNGIRYIVAPFEADSQ EXO1_YEAST 137 44 -
LELLGIPYVQAPGEGEAQ O27670 139 44 -
CKLHSIPYIVAPFEADPQ DIN7_YEAST 137 44 -
LTNAGIPWIESPGEAEAQ O44737 485 397 -
RSMTNVDIVVAPYEADAQ O62245 786 45 -
LTELGIKVIIAPGDGEAQ Q22418 120 29 -
LKILGIPASFSPIGVEAE YA31_SCHPO 285 189 -

Motif 4 width=21
Element Seqn Id St Int Rpt
LVKAGKVYAAATEDMDCLTFG FEN1_HUMAN 166 3 -
LAKAGKVYAAATEDMDCLTFG FEN1_MOUSE 164 3 -
LVKAGKVYAAATEDMDALTFG P70054 166 3 -
LVKAGKVYAAATEDMDALTFG P70040 166 3 -
LDLSDQTSGTITDDSDIWLFG Q61528 796 3 -
LDLSDQTSGTITDDSDIWLFG Q64248 796 3 -
LDLSDQTSGTITDDSDIWLFG XPG_MOUSE 810 3 -
LVKAGKVYAAATEDMDALTFG O57351 166 3 -
LDLTDQTSGTITDDSDIWLFG XPG_HUMAN 797 3 -
LDLTDQTSGTITDDSDIWLFG XPG_XENLA 830 3 -
LARSGKVYAAASEDMDTLCFQ RAD2_SCHPO 167 3 -
LCKSGKVYGVASEDMDSLTFG O65251 200 3 -
LAKKGKVYAAASEDMDTLCYR RA27_YEAST 164 3 -
LLELKLVDGIVTDDSDVFLFG O59728 785 3 -
LLELKLVDGIVTDDSDVFLFG RA13_SCHPO 786 3 -
LLQLNLVDGIITDDSDVFLFG RAD2_YEAST 800 3 -
MASKGDVYASASQDYDSLLFG O50123 160 3 -
LNKAGIVQAIITEDSDLLAFG O60545 158 3 -
LNKAGIVQAIITEDSDLLAFG O75214 158 3 -
LNKAGIVQAIITEDSDLLAFG O75466 158 3 -
MAAKGDVEYTGSQDYDSLLFG O29975 159 3 -
MAKKGDVWAVVSQDYDALLYG Q58839 160 3 -
LEKENIIDGIITEDSDMLVFG EXO1_SCHPO 158 3 -
LNRADVAQYIITEDSDLTLFG Q24557 158 3 -
LNRADVAQYIITEDSDLTLFG Q24558 158 3 -
LEQKNIVQGIISEDSDLLVFG EXO1_YEAST 158 3 -
MVKMGDAWAVASQDYDCLLFG O27670 160 3 -
LEKMGLIQGIISEDSDLLVFG DIN7_YEAST 158 3 -
LERLGLVDGVVSDDSDVWAFG O44737 506 3 -
LVQEKLVDAVITEDSDLIVFG O62245 807 3 -
LEDLGVTSGCITTDFDYFLFG Q22418 141 3 -
ISQNNLAYAVATQDTDVLLLG YA31_SCHPO 308 5 -

Motif 5 width=16
Element Seqn Id St Int Rpt
FVDLCILLGSDYCESI FEN1_HUMAN 223 36 -
FVDLCILLGSDYCESI FEN1_MOUSE 221 36 -
FVDLCILLGSDYCETI P70054 223 36 -
FVDLCILLGSDYCETI P70040 223 36 -
LINLAYLLGSDYTEGI Q61528 850 33 -
LINLAYLLGSDYTEGI Q64248 850 33 -
LINLAYLLGSDYTEGI XPG_MOUSE 864 33 -
FVDLCILLGSDYCETI O57351 223 36 -
LINLAYLLGSDYTEGI XPG_HUMAN 851 33 -
LINLAYLLGSDYTEGI XPG_XENLA 884 33 -
FVDLCILLGCDYCEPI RAD2_SCHPO 224 36 -
FIDLCILSGCDYCDSI O65251 257 36 -
FVDLCIMLGCDYCESI RA27_YEAST 221 36 -
LIKLAHLLGSDYTMGL O59728 839 33 -
LIKLAHLLGSDYTMGL RA13_SCHPO 840 33 -
MIELAQLLGSDYTNGL RAD2_YEAST 854 33 -
LIELAILVGTDYNPGG O50123 226 45 -
FRYMCILSGCDYLSSL O60545 215 36 -
FRYMCILSGCDYLSSL O75214 215 36 -
FRYMCILSGCDYLSSL O75466 215 36 -
LIDIAILVGTDYNEGV O29975 225 45 -
LIDIAIFMGTDYNPGG Q58839 214 33 -
LRHMAIFSGCDYTDGV EXO1_SCHPO 215 36 -
FRRMCILSGCDYLDSL Q24557 216 37 -
FRRMCILSGCDYLDSL Q24558 216 37 -
IITMVCLSGCDYTNGI EXO1_YEAST 217 38 -
LVDMALLVGTDFNEGV O27670 216 35 -
FRNLVCLAGCDYTSGI DIN7_YEAST 217 38 -
YISIALLSGGDYCAGL O44737 565 38 -
FRRICILSGCDYLQAG O62245 868 40 -
LISTAILLGCDYFQRG Q22418 202 40 -
FQDYCLMCGTDFTSRI YA31_SCHPO 365 36 -