SPRINT Home UMBER Home Contents Standard Search Advanced Search Relation Search

==SPRINT==> PRINTS View



  selected as


PR00762

Identifier
CLCHANNEL  [View Relations]  [View Alignment]  
Accession
PR00762
No. of Motifs
7
Creation Date
24-AUG-1997  (UPDATE 23-SEP-1999)
Title
Chloride channel signature
Database References
PRINTS; PR01111 CLCHANNEL0; PR01112 CLCHANNEL1; PR01113 CLCHANNEL2
PRINTS; PR01114 CLCHANNEL3; PR01115 CLCHANNEL4; PR01116 CLCHANNEL5
PRINTS; PR01117 CLCHANNEL6; PR01118 CLCHANNEL7; PR01119 CLCHANNELKDY
PRINTS; PR01120 CLCHANNELPLT
PFAM; PF00654 voltage_CLC
INTERPRO; IPR001807
Literature References
1. JENTSCH, T.J. AND GUNTHER, W.
Chloride channels: an emerging molecular picture.
BIOESSAYS 19 117-126 (1997).
 
2. JENTSCH, T.J., STEINMEYER, K. AND SCHWARZ, G.
Primary structure of Torpedo marmorata chloride channel isolated by
expression cloning in Xenopus oocytes.
NATURE 348 510-514 (1990).
 
3. SCHMIDT-ROSE, T. AND JENTSCH, T.J.
Transmembrane topology of a CLC chloride channel.
PROC.NATL.ACAD.SCI.U.S.A. 94 7633-7638 (1997).
 
4. LEHMANN-HORN, F., MAILANDER, V., HEINE, R. AND GEORGE, A.L.
Myotonia levior is a chloride channel disorder.
HUM.MOL.GENET. 4 1397-1402 (1995).
 
5. LLOYD, S.E., PEARCE, S.H.S., FISHER, S.E., STEINMEYER, K.,
SCHWAPPACH, B., SCHEINMAN, S.J., HARDING, B., BOLINO, A., DEVOTO, M.,
GOODYER, P., RIGDEN, S.P.A., WRONG, O., JENTSCH, T.J., CRAIG, I.W. AND
THAKKER, R.V.
A common molecular basis for three inherited kidney stone diseases.
NATURE 379 445-449 (1996).

Documentation
Chloride channels (CLCs) constitute an evolutionarily well-conserved family
of voltage-gated channels that are structurally unrelated to the other
known voltage-gated channels. They are found in organisms ranging from
bacteria to yeasts and plants, and also to animals. Their functions in
higher animals likely include the regulation of cell volume, control of
electrical excitability and trans-epithelial transport [1].
 
The first member of the family (CLC-0) was expression-cloned from the
electric organ of Torpedo marmorata [2], and subsequently nine CLC-like
proteins have been cloned from mammals. They are thought to function as
multimers of two or more identical or similar subunits, and they have
varying tissue distributions and functional properties. To date, CLC-0, 
CLC-1, CLC-2, CLC-4 and CLC-5 have been demonstrated to form functional
Cl-channels; whether the remaining isoforms do so is either contested or 
unproven. One possible explanation for the difficulty in expressing 
activatable Cl- channels is that some of the isoforms may function as Cl- 
channels of intracellular compartments, rather than of the plasma membrane.
However, they are all thought to have a similar transmembrane (TM)
topology, initial hydropathy analysis suggesting 13 hydrophobic stretches
long enough to form putative TM domains [2]. Recently, the postulated TM
topology has been revised, and it now seems likely that the CLCs have 10
(or possibly 12) TM domains, with both N- and C-termini residing in the
cytoplasm [3].
 
A number of human disease-causing mutations have been identified in the
genes encoding CLCs. Mutations in CLCN1, the gene encoding CLC-1, the major
skeletal muscle Cl- channel, lead to both recessively and dominantly-
inherited forms of muscle stiffness or myotonia [4]. Similarly, mutations
in CLCN5, which encodes CLC-5, a renal Cl- channel, lead to several forms 
of inherited kidney stone disease [5]. These mutations have been
demonstrated to reduce or abolish CLC function.
 
CLCHANNEL is a 7-element fingerprint that provides a signature for the major
skeletal muscle chloride channel proteins. The fingerprint was derived from
an initial alignment of 15 sequences: the motifs were drawn from conserved
regions spanning the N-terminal half of the alignment: motif 1 lies between
putative TM regions 2 and 3; motifs 2-5 lie in the third, fifth, tenth and
eleventh TM regions; motif 6 includes part of the twelfth TM region; and 
motif 7 lies in the cytoplasmic domain preceding the final TM region. Three 
iterations on OWL29.4 were required to reach convergence, at which point a
true set comprising 46 sequences was identified. Several partial matches
were also found, all of which are fragments and family members that fail to
make significant matches with one or more motifs.
 
An update on SPTR37_9f identified a true set of 50 sequences, and 14
partial matches.
Summary Information
  50 codes involving  7 elements
0 codes involving 6 elements
2 codes involving 5 elements
1 codes involving 4 elements
8 codes involving 3 elements
3 codes involving 2 elements
Composite Feature Index
750505050505050
60000000
52222110
41111000
33885000
22300010
1234567
True Positives
CICH_TORCA    CICH_TORMA    CICK_HUMAN    CICK_RABIT    
CICK_RAT CICL_HUMAN CICL_RABIT CICL_RAT
CLC1_HUMAN CLC1_RAT CLC2_HUMAN CLC2_RABIT
CLC2_RAT CLC3_HUMAN CLC3_MOUSE CLC3_RAT
CLC4_HUMAN CLC4_MOUSE CLC4_RAT CLC5_HUMAN
CLC5_RAT CLC6_HUMAN CLC6_MOUSE CLC7_RAT
GEF1_YEAST O13080 O14864 O14918
O18894 O54821 O54822 O60159
O60958 O64990 O70496 O81491
P92941 P92942 P92943 P93567
P97274 Q17804 Q18368 Q19067
Q21791 Q22270 Q22833 Q40485
Q96282 Q96325
True Positive Partials
Codes involving 5 elements
P74477 YADQ_ECOLI
Codes involving 4 elements
O57747
Codes involving 3 elements
O28857 O54823 P73745 P76175
P77195 P96820 Q99428 Y305_METJA
Codes involving 2 elements
O66749 Q99427 Q99429
Sequence Titles
CICH_TORCA  CHLORIDE CHANNEL PROTEIN (CLC-0) - TORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY). 
CICH_TORMA CHLORIDE CHANNEL PROTEIN - TORPEDO MARMORATA (MARBLED ELECTRIC RAY).
CICK_HUMAN CHLORIDE CHANNEL PROTEIN CLC-KA (CLC-K1) - HOMO SAPIENS (HUMAN).
CICK_RABIT CHLORIDE CHANNEL PROTEIN CLC-K1 - ORYCTOLAGUS CUNICULUS (RABBIT).
CICK_RAT CHLORIDE CHANNEL PROTEIN CLC-K1 - RATTUS NORVEGICUS (RAT).
CICL_HUMAN CHLORIDE CHANNEL PROTEIN CLC-KB (CLC-K2) - HOMO SAPIENS (HUMAN).
CICL_RABIT CHLORIDE CHANNEL PROTEIN CLC-K2 - ORYCTOLAGUS CUNICULUS (RABBIT).
CICL_RAT CHLORIDE CHANNEL PROTEIN CLC-K2 - RATTUS NORVEGICUS (RAT).
CLC1_HUMAN CHLORIDE CHANNEL PROTEIN, SKELETAL MUSCLE (CHLORIDE CHANNEL PROTEIN 1) (CLC-1) - HOMO SAPIENS (HUMAN).
CLC1_RAT CHLORIDE CHANNEL PROTEIN, SKELETAL MUSCLE (CHLORIDE CHANNEL PROTEIN 1) (CLC-1) - RATTUS NORVEGICUS (RAT).
CLC2_HUMAN CHLORIDE CHANNEL PROTEIN 2 (CLC-2) - HOMO SAPIENS (HUMAN).
CLC2_RABIT CHLORIDE CHANNEL PROTEIN 2 (CLC-2) (PKA-ACTIVATED CHLORIDE CHANNEL) - ORYCTOLAGUS CUNICULUS (RABBIT).
CLC2_RAT CHLORIDE CHANNEL PROTEIN 2 (CLC-2) - RATTUS NORVEGICUS (RAT).
CLC3_HUMAN CHLORIDE CHANNEL PROTEIN 3 (CLC-3) - HOMO SAPIENS (HUMAN).
CLC3_MOUSE CHLORIDE CHANNEL PROTEIN 3 (CLC-3) - MUS MUSCULUS (MOUSE).
CLC3_RAT CHLORIDE CHANNEL PROTEIN 3 (CLC-3) - RATTUS NORVEGICUS (RAT).
CLC4_HUMAN CHLORIDE CHANNEL PROTEIN 4 (CLC-4) - HOMO SAPIENS (HUMAN).
CLC4_MOUSE CHLORIDE CHANNEL PROTEIN 4 (CLC-4) - MUS MUSCULUS (MOUSE).
CLC4_RAT CHLORIDE CHANNEL PROTEIN 4 (CLC-4) - RATTUS NORVEGICUS (RAT).
CLC5_HUMAN CHLORIDE CHANNEL PROTEIN 5 (CLC-5) - HOMO SAPIENS (HUMAN).
CLC5_RAT CHLORIDE CHANNEL PROTEIN 5 (CLC-5) - RATTUS NORVEGICUS (RAT).
CLC6_HUMAN CHLORIDE CHANNEL PROTEIN 6 (CLC-6) (KIAA0046) - HOMO SAPIENS (HUMAN).
CLC6_MOUSE CHLORIDE CHANNEL PROTEIN 6 (CLC-6) - MUS MUSCULUS (MOUSE).
CLC7_RAT CHLORIDE CHANNEL PROTEIN 7 (CLC-7) - RATTUS NORVEGICUS (RAT).
GEF1_YEAST GEF1 PROTEIN (VOLTAGE-GATED CHLORIDE CHANNEL) (CLC-Y1) (CLC-A) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
O13080 CHLORIDE CHANNEL CLC-5 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O14864 CHLORIDE CHANNEL PROTEIN - HOMO SAPIENS (HUMAN).
O14918 CHLORIDE CHANNEL PROTEIN 3 - HOMO SAPIENS (HUMAN).
O18894 CHLORIDE CHANNEL PROTEIN 3 - ORYCTOLAGUS CUNICULUS (RABBIT).
O54821 CHLORIDE CHANNEL 2 - RATTUS NORVEGICUS (RAT).
O54822 CHLORIDE CHANNEL 2 - RATTUS NORVEGICUS (RAT).
O60159 VOLTAGE-GATED CHLORIDE CHANNEL - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O60958 CCP - LEISHMANIA MAJOR.
O64990 ANION CHANNEL PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O70496 PUTATIVE CHLORIDE CHANNEL PROTEIN CLC7 - MUS MUSCULUS (MOUSE).
O81491 F9D12.10 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P92941 CLC-A CHLORIDE CHANNEL PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P92942 CLC-B CHLORIDE CHANNEL PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P92943 CLC-D CHLORIDE CHANNEL PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P93567 CHLORIDE CHANNEL STCLC1 - SOLANUM TUBEROSUM (POTATO).
P97274 VOLUME-REGULATED OUTWARDLY-RECTIFYING CHLORIDE CHANNEL - CAVIA PORCELLUS (GUINEA PIG).
Q17804 C07H4.2 PROTEIN - CAENORHABDITIS ELEGANS.
Q18368 B0491.8 PROTEIN - CAENORHABDITIS ELEGANS.
Q19067 SIMILAR TO T. MARMORATA CHLORIDE CHANNEL PROTEIN - CAENORHABDITIS ELEGANS.
Q21791 R07B7.1 PROTEIN - CAENORHABDITIS ELEGANS.
Q22270 SIMILAR TO CHLORIDE CHANNEL PROTEIN AND TO C. ELEGANS PROTEIN E04F6.11 - CAENORHABDITIS ELEGANS.
Q22833 T27D12.2 PROTEIN - CAENORHABDITIS ELEGANS.
Q40485 VOLTAGE-DEPENDENT CHLORIDE CHANNEL - NICOTIANA TABACUM (COMMON TOBACCO).
Q96282 CHLORIDE CHANNEL - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
Q96325 VOLTAGE-GATED CHLORIDE CHANNEL - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).

P74477 CHLORIDE CHANNEL PROTEIN - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
YADQ_ECOLI HYPOTHETICAL 46.0 KD PROTEIN IN HEML-PFS INTERGENIC REGION - ESCHERICHIA COLI.

O57747 370AA LONG HYPOTHETICAL PROTEIN - PYROCOCCUS HORIKOSHII.

O28857 CHLORIDE CHANNEL, PUTATIVE - ARCHAEOGLOBUS FULGIDUS.
O54823 CHLORIDE CHANNEL 2 - RATTUS NORVEGICUS (RAT).
P73745 HYPOTHETICAL 48.4 KD PROTEIN - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
P76175 FROM BASES 1663181 TO 1676139 (SECTION 145 OF 400) OF THE COMPLETE GENOME (SECTION 145 OF 400) - ESCHERICHIA COLI.
P77195 SIMILAR TO - ESCHERICHIA COLI.
P96820 HYPOTHETICAL 50.8 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
Q99428 CHLORIDE CHANNEL - HOMO SAPIENS (HUMAN).
Y305_METJA HYPOTHETICAL PROTEIN MJ0305 - METHANOCOCCUS JANNASCHII.

O66749 HYPOTHETICAL 34.5 KD PROTEIN - AQUIFEX AEOLICUS.
Q99427 CLC-6 CHLORIDE CHANNEL - HOMO SAPIENS (HUMAN).
Q99429 CHLORIDE CHANNEL - HOMO SAPIENS (HUMAN).
Scan History
OWL29_4    3  100  NSINGLE    
SPTR37_9f 3 130 NSINGLE
Initial Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
PQAVGSGIPEMKTILRGV CLC2_RAT 163 163 -
PQAVGSGIPEMKTILRGV CLC2_RABIT 160 160 -
PQAVGSGIPEMKTILRGV CLC1_RAT 184 184 -
PQAVGSGIPEMKTILRGV CLC1_HUMAN 184 184 -
PVAAGSGIPEVKCYLNGV CLC6_HUMAN 152 152 -
PVAAGSGIPQIKCFLNGV CLC7_RAT 197 197 -
PVAAGSGIPQIKCFLNGV CLC7_HUMAN 183 183 -
PYACGSGIPEIKTILSGF CLC5_HUMAN 163 163 -
PYACGSGIPEIKTILSGF CLC5_RAT 163 163 -
PYACGSGIPEIKTILSGF CLC3_HUMAN 176 176 -
PYACGSGIPEIKTILSGF CLC3_RAT 176 176 -
PYACGSGIPEIKTILSGF CLC3_MOUSE 176 176 -
PYACGSGIPEIKTILSGF CLC4_RAT 163 163 -
PYRCGSGIPEIKTILSGF CLC4_HUMAN 176 176 -
PQAVGSGIPEMKTILRGV CLC2_HUMAN 157 157 -

Motif 2 width=20
Element Seqn Id St Int Rpt
KVIGLTCALGSGMPLGKEGP CLC2_RAT 194 13 -
KVVALTAGLGSGIPVGKEGP CLC1_RAT 215 13 -
KVVALTAGLGSGIPVGKEGP CLC1_HUMAN 215 13 -
KVLGVLFSVAGGLFVGKEGP CLC6_HUMAN 183 13 -
KVSGVILSVVGGLAVGKEGP CLC7_RAT 228 13 -
KVSGVILSVVGGLAVGKEGP CLC7_HUMAN 214 13 -
KTITLVLAVSSGLSLGKEGP CLC5_HUMAN 194 13 -
KTITLVLAVSSGLSLGKEGP CLC5_RAT 194 13 -
KTITLVLAVASGLSLGKEGP CLC3_HUMAN 207 13 -
KTITLVLAVASGLSLGKEGP CLC3_RAT 207 13 -
KTITLVLAVASGLSLGKEGP CLC3_MOUSE 207 13 -
KTVTLVLVVSSGLSLGKEGP CLC4_RAT 194 13 -
KTVTLVLVVSSGLSLGKEGP CLC4_HUMAN 207 13 -
KVIGLTCALGSGMPLGKEGP CLC2_HUMAN 188 13 -
KVIGLTCALGSGMPLGKEGP CLC2_RABIT 191 13 -

Motif 3 width=20
Element Seqn Id St Int Rpt
AVGVGCCFAAPIGGVLFSIE CLC2_RABIT 248 37 -
AVGVGCCFGTPLGGVLFSIE CLC1_HUMAN 272 37 -
AAGVSAAFGAPVGGVLFSLE CLC7_HUMAN 278 44 -
AAGVSAAFGAPVGGVLFSLE CLC7_RAT 292 44 -
AAGVAAAFGAPIGGTLFSLE CLC6_HUMAN 247 44 -
AAGVSVAFGAPIGGVLFSLE CLC5_HUMAN 248 34 -
AAGVSVAFGAPIGGVLFSLE CLC5_RAT 248 34 -
AAGVSVAFGAPIGGVLFSLE CLC3_HUMAN 261 34 -
AAGVSVAFGAPIGGVLFSLE CLC3_RAT 261 34 -
AAGVSVAFGAPIGGVLFSLE CLC3_MOUSE 261 34 -
AAGVSVAFGAPIGGVLFSLE CLC4_RAT 248 34 -
AAGVSVAFGAPIGGVLFSLE CLC4_HUMAN 261 34 -
AVGVGCCFAAPIGGVLFSIE CLC2_HUMAN 245 37 -
AVGVGCCFAAPIGGVLFSIE CLC2_RAT 251 37 -
AVGVGCCFGTPLGGVLFSIE CLC1_RAT 272 37 -

Motif 4 width=21
Element Seqn Id St Int Rpt
VPSGLFIPSMAIGAIAGRIVG CLC3_RAT 464 183 -
VSAGVFIPSLLIGAAWGRLFG CLC7_HUMAN 493 195 -
IPSGLFIPSMAVGAIAGRLLG CLC5_HUMAN 450 182 -
IPSGLFIPSMAVGAIAGRLLG CLC5_RAT 450 182 -
VPSGLFIPSMAIGAIAGRIVG CLC3_HUMAN 464 183 -
VPSGLFIPSMAIGAIAGRIVG CLC3_MOUSE 464 183 -
IPSGLFIPSMAVGAMAGRMVG CLC4_RAT 451 183 -
IPSGLFIPSMAVGAIAGRMVG CLC4_HUMAN 464 183 -
VPCGAFMPVFVIGAAFGRLVG CLC2_HUMAN 454 189 -
VPCGAFMPVFVIGAAFGRLVG CLC2_RAT 460 189 -
VPCGAFMPVFVIGAAFGRLVG CLC2_RABIT 457 189 -
IPCGGFMPVFVLGAAFGRLVG CLC1_RAT 479 187 -
IPCGGFMPVFVLGAAFGRLVG CLC1_HUMAN 479 187 -
VPSGLFVPSLLCGAAFGRLVA CLC6_HUMAN 484 217 -
VSAGVFIPSLLIGAAWGRLFG CLC7_RAT 507 195 -

Motif 5 width=17
Element Seqn Id St Int Rpt
GTFALIGAAAFLGGVVR CLC6_HUMAN 519 14 -
GKYALMGAAAQLGGIVR CLC7_HUMAN 529 15 -
GKYALMGAAAQLGGIVR CLC7_RAT 543 15 -
GLYAMVGAAACLGGVTR CLC5_HUMAN 500 29 -
GLYAMVGAAACLGGVTR CLC5_RAT 500 29 -
GLYAMVGAAACLGGVTR CLC3_HUMAN 514 29 -
GLYAMVGAAACLGGVTR CLC3_RAT 514 29 -
GLYAMVGAAACLGGVTR CLC3_MOUSE 514 29 -
GLYAMVGAAACLGGVTR CLC4_RAT 501 29 -
GLYAMVGAAACLGGVTR CLC4_HUMAN 514 29 -
GGYAVVGAAALAGAVTH CLC2_HUMAN 497 22 -
GGYAVVGAAALAGAVTH CLC2_RAT 503 22 -
GGYAVVGAAALAGAVTH CLC2_RABIT 500 22 -
GGYAVIGAAALTGAVSH CLC1_RAT 522 22 -
GGYAVIGAAALTGAVSH CLC1_HUMAN 522 22 -

Motif 6 width=20
Element Seqn Id St Int Rpt
TVSTAVICFELTGQIAHILP CLC1_RAT 539 0 -
TVSLVVIMFELTGGLEYIVP CLC5_HUMAN 518 1 -
TVSLVVIMFELTGGLEYIVP CLC5_RAT 518 1 -
TVSLVVIVFELTGGLEYIVP CLC3_HUMAN 532 1 -
TVSLVVIVFELTGGLEYIVP CLC3_RAT 532 1 -
TVSLVVIVFELTGGLEYIVP CLC3_MOUSE 532 1 -
TVSLVVIMFELTGGLEYIVP CLC4_RAT 519 1 -
TVSLVVIMFELTGGLEYIVP CLC4_HUMAN 532 1 -
TVSTAVIVFELTGQIAHILP CLC2_HUMAN 514 0 -
TVSTAVIVFELTGQIAHILP CLC2_RAT 520 0 -
TVSTAVIVFELTGQIAHILP CLC2_RABIT 517 0 -
TVSTAVICFELTGQIAHILP CLC1_HUMAN 539 0 -
TISLTVILIESTNEITYGLP CLC6_HUMAN 537 1 -
TLSLTVIMMEATSNVTYGFP CLC7_RAT 561 1 -
TLSLTVIMMEATSNVTYGFP CLC7_HUMAN 547 1 -

Motif 7 width=15
Element Seqn Id St Int Rpt
LYDSIIRIKKLPYLP CLC2_RABIT 555 18 -
LYDMHIQLQSVPFLH CLC7_RAT 599 18 -
IYDAHIRLNGYPFLE CLC5_HUMAN 557 19 -
LYDMHIQLQSVPFLH CLC7_HUMAN 585 18 -
LYDSIIQVKKLPYLP CLC1_RAT 577 18 -
IYDAHIRLNGYPFLE CLC5_RAT 557 19 -
IYEAHIRLNGYPFLD CLC3_HUMAN 571 19 -
IYEAHIRLNGYPFLD CLC3_RAT 571 19 -
IYDIHVGLRGVPLLE CLC6_HUMAN 575 18 -
IYEAHIRLNGYPFLD CLC3_MOUSE 571 19 -
IYEAHIHLNGYPFLD CLC4_RAT 558 19 -
IYEAHIHLNGYPFLD CLC4_HUMAN 571 19 -
LYDSIIQVKKLPYLP CLC1_HUMAN 577 18 -
LYDSIIRIKKLPYLP CLC2_HUMAN 552 18 -
LYDSIIRIKKLPYLP CLC2_RAT 558 18 -
Final Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
PYACGSGIPEIKTILSGF CLC5_HUMAN 163 163 -
PYACGSGIPEIKTILSGF CLC5_RAT 163 163 -
PYACGSGIPEIKTILSGF CLC3_HUMAN 176 176 -
PYACGSGIPEIKTILSGF O18894 234 234 -
PYACGSGIPEIKTILSGF O14918 234 234 -
PYACGSGIPEIKTILSGF CLC3_RAT 176 176 -
PYACGSGIPEIKTILSGF CLC3_MOUSE 176 176 -
PYACGSGIPEIKTILSGF CLC4_MOUSE 163 163 -
PYACGSGIPEIKTILSGF CLC4_RAT 163 163 -
PYACGSGIPEIKTILSGF O13080 225 225 -
PYRCGSGIPEIKTILSGF CLC4_HUMAN 176 176 -
PQAVGSGIPEMKTILRGV CLC2_HUMAN 157 157 -
PQAVGSGIPEMKTILRGV O54822 163 163 -
PQAVGSGIPEMKTILRGV O54821 163 163 -
PQAVGSGIPEMKTILRGV O14864 157 157 -
PQAVGSGIPEMKTILRGV CLC2_RAT 163 163 -
PQAVGSGIPEMKTILRGV CLC2_RABIT 160 160 -
PYACGSGIPEIKTILSGF P97274 176 176 -
PYACGSGIPEIKCILSGF Q17804 158 158 -
PQAIGSGIPEMKTILRGV Q19067 96 96 -
PQAVGSGIPEMKTILRGV CLC1_RAT 184 184 -
PQAVGSGIPEMKTILRGV CLC1_HUMAN 184 184 -
PQAVGSGIPELKTIIRGA CICH_TORMA 118 118 -
PQAVGSGIPELKTIIRGA CICH_TORCA 117 117 -
KQAVGSGIPEVKVIMHGF Q18368 120 120 -
PTAAGPGIPEIKAYLNGV P92942 154 154 -
PVAAGSGIPEIKCYLNGV CLC6_MOUSE 152 152 -
PVAAGSGIPEVKCYLNGV CLC6_HUMAN 152 152 -
PSSGGSGIPELKTMLAGV CICK_HUMAN 116 116 -
PFSGGSGIPELKTILSGV CICK_RABIT 116 116 -
PFSGGSGIPELKTILSGV CICL_RABIT 116 116 -
PAAAGSGIPEIKGYLNGI O81491 157 157 -
PAAAGSGIPEIKGYLNGI P92943 144 144 -
PTAAGPGIPEIKAYLNGI O64990 155 155 -
PTAAGPGIPEIKAYLNGI Q96325 155 155 -
PTAAGPGIPEIKAYLNGI P92941 155 155 -
PAAAGSGIPEVKAYLNGI Q40485 165 165 -
PLAAGSGISEIKCIISGF O60159 203 203 -
PFSGGSGLPELKTMLSGV CICK_RAT 116 116 -
PVAAGSGIPQIKCFLNGV O70496 197 197 -
PVAAGSGIPQIKCFLNGV CLC7_RAT 197 197 -
PIAGGSGIPQIKCYLNGI Q21791 196 196 -
PSSGGSGIPEVKTMLAGV CICL_HUMAN 116 116 -
PQAIGSGIPEMKTIIRGV Q22270 140 140 -
PSSGGSGIPEVKTILTGV CICL_RAT 116 116 -
PAAAGSGIPEVKAYLNGI P93567 150 150 -
PAAAGSGIPEVKAYLNGI Q96282 164 164 -
KQAVGSGIPEVKVIIHGF Q22833 173 173 -
PMATGSGISEIKVWVSGF GEF1_YEAST 181 181 -
PYASGGGIAEVKTIVSGH O60958 184 184 -

Motif 2 width=20
Element Seqn Id St Int Rpt
KTITLVLAVSSGLSLGKEGP CLC5_HUMAN 194 13 -
KTITLVLAVSSGLSLGKEGP CLC5_RAT 194 13 -
KTITLVLAVASGLSLGKEGP CLC3_HUMAN 207 13 -
KTITLVLAVASGLSLGKEGP O18894 265 13 -
KTITLVLAVASGLSLGKEGP O14918 265 13 -
KTITLVLAVASGLSLGKEGP CLC3_RAT 207 13 -
KTITLVLAVASGLSLGKEGP CLC3_MOUSE 207 13 -
KTVTLVLVVSSGLSLGKEGP CLC4_MOUSE 194 13 -
KTVTLVLVVSSGLSLGKEGP CLC4_RAT 194 13 -
KTMTLVLAVSSGLSLGKEGP O13080 256 13 -
KTVTLVLVVSSGLSLGKEGP CLC4_HUMAN 207 13 -
KVIGLTCALGSGMPLGKEGP CLC2_HUMAN 188 13 -
KVIGLTCALGSGMPLGKEGP O54822 194 13 -
KVIGLTCALGSGMPLGKEGP O54821 194 13 -
KVIGLTCALGSGMPLGKEGP O14864 188 13 -
KVIGLTCALGSGMPLGKEGP CLC2_RAT 194 13 -
KVIGLTCALGSGMPLGKEGP CLC2_RABIT 191 13 -
KTITLVLAVASGLSLGKEGP P97274 207 13 -
KSVGLILSSASGLSLGKEGP Q17804 189 13 -
KMIGLTLSLGSGLPMGKEGP Q19067 127 13 -
KVVALTAGLGSGIPVGKEGP CLC1_RAT 215 13 -
KVVALTAGLGSGIPVGKEGP CLC1_HUMAN 215 13 -
KTVGLTVALSAGFPLGKEGP CICH_TORMA 149 13 -
KTVGLTVALSAGFPLGKEGP CICH_TORCA 148 13 -
KMVGLTLAMGGGLPIGKEGP Q18368 151 13 -
KIVGSIGAVAAGLDLGKEGP P92942 185 13 -
KVFGVLFSVSGGLFVGKEGP CLC6_MOUSE 183 13 -
KVLGVLFSVAGGLFVGKEGP CLC6_HUMAN 183 13 -
VGLSCTLATGSTLFLGKVGP CICK_HUMAN 149 15 -
VGLSCTLATGSTLFLGKVGP CICK_RABIT 149 15 -
VGLSCTLATGSTLFLGKVGP CICL_RABIT 149 15 -
KIFGSIGSVGGGLALGKEGP O81491 188 13 -
KIFGSIGSVGGGLALGKEGP P92943 175 13 -
KIVGSIGAVAAGLDLGKEGP O64990 186 13 -
KIVGSIGAVAAGLDLGKEGP Q96325 186 13 -
KIVGSIGAVAAGLDLGKEGP P92941 186 13 -
KIFGSALGVSAGFVVGKEGP Q40485 196 13 -
KCVGLPLAIASGLSVGKEGP O60159 234 13 -
VGLSCTLATGSTIFLGKVGP CICK_RAT 149 15 -
KVSGVILSVVGGLAVGKEGP O70496 228 13 -
KVSGVILSVVGGLAVGKEGP CLC7_RAT 228 13 -
KAVGVACSVGGGLCAGKEGP Q21791 227 13 -
VGLSCTLACGSTLFLGKVGP CICL_HUMAN 149 15 -
KIFGVAMALGSGVPIGKMGP Q22270 171 13 -
VGLSCTLATGSTIFLGKLGP CICL_RAT 149 15 -
KIFGSILGVSAGFVVGKEGP P93567 181 13 -
KIFGSIFGVAAGFVVGKEGP Q96282 195 13 -
KMIGLTLTIGSGLPVGKEGP Q22833 204 13 -
KSVALPLAISSGLSVGKEGP GEF1_YEAST 213 14 -
KVVGMCFSTGSGLTVGKEGP O60958 215 13 -

Motif 3 width=20
Element Seqn Id St Int Rpt
AAGVSVAFGAPIGGVLFSLE CLC5_HUMAN 248 34 -
AAGVSVAFGAPIGGVLFSLE CLC5_RAT 248 34 -
AAGVSVAFGAPIGGVLFSLE CLC3_HUMAN 261 34 -
AAGVSVAFGAPIGGVLFSLE O18894 319 34 -
AAGVSVAFGAPIGGVLFSLE O14918 319 34 -
AAGVSVAFGAPIGGVLFSLE CLC3_RAT 261 34 -
AAGVSVAFGAPIGGVLFSLE CLC3_MOUSE 261 34 -
AAGVSVAFGAPIGGVLFSLE CLC4_MOUSE 248 34 -
AAGVSVAFGAPIGGVLFSLE CLC4_RAT 248 34 -
AAGVSVAFGAPIGGVLFSLE O13080 310 34 -
AAGVSVAFGAPIGGVLFSLE CLC4_HUMAN 261 34 -
AVGVGCCFAAPIGGVLFSIE CLC2_HUMAN 245 37 -
AVGVGCCFAAPIGGVLFSIE O54822 251 37 -
AVGVGCCFAAPIGGVLFSIE O54821 251 37 -
AVGVGCCFAAPIGGVLFSIE O14864 245 37 -
AVGVGCCFAAPIGGVLFSIE CLC2_RAT 251 37 -
AVGVGCCFAAPIGGVLFSIE CLC2_RABIT 248 37 -
AAGVSVAFGAPIGGVLFSLE P97274 261 34 -
AAGVSVAFGAPIGGVLFSLE Q17804 243 34 -
AVGVACTFSAPIGGVLFSIE Q19067 185 38 -
AVGVGCCFGTPLGGVLFSIE CLC1_RAT 272 37 -
AVGVGCCFGTPLGGVLFSIE CLC1_HUMAN 272 37 -
ALGISCCFGTPLAGVLFSIE CICH_TORMA 207 38 -
ALGISCCFGTPLAGVLFSIE CICH_TORCA 206 38 -
AVGIACTFSAPIGAVLYAIE Q18368 210 39 -
AAGVCAAFRSPVGGVLFALE P92942 249 44 -
AAGVAAAFGAPIGGTLFSLE CLC6_MOUSE 247 44 -
AAGVAAAFGAPIGGTLFSLE CLC6_HUMAN 247 44 -
AVGVATVFAAPFSGVLFSIE CICK_HUMAN 206 37 -
AVGVATVFAAPFSGVLFCIE CICK_RABIT 206 37 -
AVGVATVFAAPFSGVLFCIE CICL_RABIT 206 37 -
AAGVAAAFRAPVGGVLFALE O81491 252 44 -
AAGVAAAFRAPVGGVLFALE P92943 239 44 -
ASGVCAAFRSPVGGVLFALE O64990 250 44 -
ASGVCAAFRSPVGGVLFALE Q96325 250 44 -
ASGVCAAFRSPVGGVLFALE P92941 250 44 -
AAGVAAAFRAPVGGVLFALE Q40485 260 44 -
ASGVAVAFGSPIGGVLFGIE O60159 288 34 -
AVGVATVFAAPFSGVLFSIE CICK_RAT 206 37 -
AAGVSAAFGAPVGGVLFSLE O70496 292 44 -
AAGVSAAFGAPVGGVLFSLE CLC7_RAT 292 44 -
AAGVAAAFGAPIGGVLFSLE Q21791 291 44 -
AVGVATVFGAPFSGVLFSIE CICL_HUMAN 206 37 -
AVGVACTFSSPVGGVLFSIE Q22270 228 37 -
AVGVATVFAAPISGVLFSIE CICL_RAT 206 37 -
AAGVAAAFRAPVGGVLFALE P93567 245 44 -
AAGVAAAFRAPVGGVLFALE Q96282 259 44 -
AVGIACTFSAPMGAVLYGIE Q22833 263 39 -
GAGVAVAFGAPIGGVLFGLE GEF1_YEAST 267 34 -
GGGMAVAFGAPVGGVIFALE O60958 268 33 -

Motif 4 width=21
Element Seqn Id St Int Rpt
IPSGLFIPSMAVGAIAGRLLG CLC5_HUMAN 450 182 -
IPSGLFIPSMAVGAIAGRLLG CLC5_RAT 450 182 -
VPSGLFIPSMAIGAIAGRIVG CLC3_HUMAN 464 183 -
VPSGLFIPSMAIGAIAGRIVG O18894 522 183 -
VPSGLFIPSMAIGAIAGRIVG O14918 522 183 -
VPSGLFIPSMAIGAIAGRIVG CLC3_RAT 464 183 -
VPSGLFIPSMAIGAIAGRIVG CLC3_MOUSE 464 183 -
IPSGLFIPSMAVGAMAGRMVG CLC4_MOUSE 451 183 -
IPSGLFIPSMAVGAMAGRMVG CLC4_RAT 451 183 -
VPSGLFIPSMAVGAIMGRLLG O13080 512 182 -
IPSGLFIPSMAVGAIAGRMVG CLC4_HUMAN 464 183 -
VPCGAFMPVFVIGAAFGRLVG CLC2_HUMAN 454 189 -
VPCGAFMPVFVIGAAFGRLVG O54822 460 189 -
VPCGAFMPVFVIGAAFGRLVG O54821 460 189 -
VPCGAFMPVFVIGAAFGRLVG O14864 454 189 -
VPCGAFMPVFVIGAAFGRLVG CLC2_RAT 460 189 -
VPCGAFMPVFVIGAAFGRLVG CLC2_RABIT 457 189 -
VPSGLFIPSMAIGAIAGRIVG P97274 464 183 -
VPCGLFVPSIGMGAIAGRILG Q17804 430 167 -
VPSGIFMPVFVLGAAFGRLVG Q19067 407 202 -
IPCGGFMPVFVLGAAFGRLVG CLC1_RAT 479 187 -
IPCGGFMPVFVLGAAFGRLVG CLC1_HUMAN 479 187 -
VPCGAFVPVFNLGAVLGRFVG CICH_TORMA 413 186 -
VPCGAFVPVFNLGAVLGRFVG CICH_TORCA 412 186 -
VPAGVFVPSFIIGAAGGRLMG Q18368 421 191 -
TPSGLFLPIILMGAAYGRMLG P92942 474 205 -
VPSGLFVPSLLCGAAFGRLVA CLC6_MOUSE 485 218 -
VPSGLFVPSLLCGAAFGRLVA CLC6_HUMAN 484 217 -
MPAGYFMPIFILGAAIGRLLG CICK_HUMAN 421 195 -
MPAGYFLPIFIIGAAIGRLLG CICK_RABIT 421 195 -
MPAGYFLPIFIIGAAIGRLLG CICL_RABIT 421 195 -
VPAGQFVPGIMIGSTYGRLVG O81491 483 211 -
VPAGQFVPGIMIGSTYGRLVG P92943 470 211 -
TPSGLFLPIILMGSAYGRMLG O64990 475 205 -
TPSGLFLPIILMGSAYGRMLG Q96325 473 203 -
TPSGLFLPIILMGSAYGRMLG P92941 475 205 -
IPSGLFIPVILAGASYGRFVG Q40485 485 205 -
VPAGIFVPSMAVGASFGYMIG O60159 487 179 -
MPAGYFMPIFIIGAAIGRLLG CICK_RAT 421 195 -
VSAGVFIPSLLIGAAWGRLFG O70496 507 195 -
VSAGVFIPSLLIGAAWGRLFG CLC7_RAT 507 195 -
VPSGVFIPAILTGAAWGRLFG Q21791 507 196 -
MPAGYFMPIFVYGAAIGRLFG CICL_HUMAN 421 195 -
VPSGVFLPVFVLGAAIGRFYG Q22270 436 188 -
IPAGYFLPIFVYGAAIGRLFG CICL_RAT 421 195 -
IPSGLFIPVILAGASYGRIFG P93567 470 205 -
IPSGLFIPVILAGASYGRLVG Q96282 485 206 -
IPSGIFVPCFVIGACGGRIFG Q22833 476 193 -
VPAGIFVPSMAVGATFGRAVS GEF1_YEAST 463 176 -
LPAGILVPSLTIGALYGRAFG O60958 450 162 -

Motif 5 width=17
Element Seqn Id St Int Rpt
GLYAMVGAAACLGGVTR CLC5_HUMAN 500 29 -
GLYAMVGAAACLGGVTR CLC5_RAT 500 29 -
GLYAMVGAAACLGGVTR CLC3_HUMAN 514 29 -
GLYAMVGAAACLGGVTR O18894 572 29 -
GLYAMVGAAACLGGVTR O14918 572 29 -
GLYAMVGAAACLGGVTR CLC3_RAT 514 29 -
GLYAMVGAAACLGGVTR CLC3_MOUSE 514 29 -
GLYAMVGAAACLGGVTR CLC4_MOUSE 501 29 -
GLYAMVGAAACLGGVTR CLC4_RAT 501 29 -
GLYAMVGAAACLGGATR O13080 562 29 -
GLYAMVGAAACLGGVTR CLC4_HUMAN 514 29 -
GGYAVVGAAALAGAVTH CLC2_HUMAN 497 22 -
GGYAVVGAAALAGAVTH O54822 503 22 -
GGYAVVGAAALAGAVTH O54821 503 22 -
GGYAVVGAAALAGAVTH O14864 497 22 -
GGYAVVGAAALAGAVTH CLC2_RAT 503 22 -
GGYAVVGAAALAGAVTH CLC2_RABIT 500 22 -
GLYAMVGAAACLSGVTR P97274 514 29 -
GLYAMVGAAAVLGGVTR Q17804 482 31 -
GVYAVVGAAAFCGAVTH Q19067 429 1 -
GGYAVIGAAALTGAVSH CLC1_RAT 522 22 -
GGYAVIGAAALTGAVSH CLC1_HUMAN 522 22 -
GEYAVIGAAAMTGAVTH CICH_TORMA 456 22 -
GEYAVIGAAAMTGAVTH CICH_TORCA 455 22 -
GLYAVVGAAAYTGAVTH Q18368 463 21 -
GLYAVLGAAALMAGSMR P92942 506 11 -
GTFALIGAAAFLGGVVR CLC6_MOUSE 520 14 -
GTFALIGAAAFLGGVVR CLC6_HUMAN 519 14 -
GGYALAGAAAFSGAVTH CICK_HUMAN 464 22 -
GGYALAGAAAFSGAVTH CICK_RABIT 464 22 -
GGYALAGAAAFSGAVTH CICL_RABIT 464 22 -
GTYALLGAASFLGGSMR O81491 518 14 -
GTYALLGAASFLGGSMR P92943 505 14 -
GLYAVLGAASLMAGSMR O64990 507 11 -
GLYAVLGAASLMAGSMR Q96325 505 11 -
GLYAVLGAASLMAGSMR P92941 507 11 -
GLFALLGAASFLGGTMR Q40485 517 11 -
GTYALLGAAASLSGIMH O60159 536 28 -
GGYALAGAAAFSGAVTH CICK_RAT 464 22 -
GKYALMGAAAQLGGIVR O70496 543 15 -
GKYALMGAAAQLGGIVR CLC7_RAT 543 15 -
GKYALAGAAAQLGGVVR Q21791 543 15 -
GGYALAGAAAFSGAVTH CICL_HUMAN 464 22 -
GIYAIVGAAAFSASVTH Q22270 472 15 -
GAYALAGAAAFSGAVTH CICL_RAT 464 22 -
GLFSLLGAASFLGGTMR P93567 502 11 -
GLFSLLGAASFLGGTMR Q96282 517 11 -
GLYAVVGAASFTGSVTH Q22833 518 21 -
GAYAFLGAAATLSGITN GEF1_YEAST 499 15 -
GVYAIVGAAAMLTGVTH O60958 499 28 -

Motif 6 width=20
Element Seqn Id St Int Rpt
TVSLVVIMFELTGGLEYIVP CLC5_HUMAN 518 1 -
TVSLVVIMFELTGGLEYIVP CLC5_RAT 518 1 -
TVSLVVIVFELTGGLEYIVP CLC3_HUMAN 532 1 -
TVSLVVIVFELTGGLEYIVP O18894 590 1 -
TVSLVVIVFELTGGLEYIVP O14918 590 1 -
TVSLVVIVFELTGGLEYIVP CLC3_RAT 532 1 -
TVSLVVIVFELTGGLEYIVP CLC3_MOUSE 532 1 -
TVSLVVIMFELTGGLEYIVP CLC4_MOUSE 519 1 -
TVSLVVIMFELTGGLEYIVP CLC4_RAT 519 1 -
TVSLVVIMFEITGGLEYIVP O13080 580 1 -
TVSLVVIMFELTGGLEYIVP CLC4_HUMAN 532 1 -
TVSTAVIVFELTGQIAHILP CLC2_HUMAN 514 0 -
TVSTAVIVFELTGQIAHILP O54822 520 0 -
TVSTAVIVFELTGQIAHILP O54821 520 0 -
TVSTAVIVFELTGQIAHILP O14864 514 0 -
TVSTAVIVFELTGQIAHILP CLC2_RAT 520 0 -
TVSTAVIVFELTGQIAHILP CLC2_RABIT 517 0 -
TVSLVVIVFELTGGLEYIVP P97274 532 1 -
TVSLVVIMFELTGSLEFIVP Q17804 500 1 -
TVSVAVIVFELTGQLCHLLP Q19067 446 0 -
TVSTAVICFELTGQIAHILP CLC1_RAT 539 0 -
TVSTAVICFELTGQIAHILP CLC1_HUMAN 539 0 -
AVSTAVICFELTGQISHVLP CICH_TORMA 473 0 -
AVSTAVICFELTGQISHVLP CICH_TORCA 472 0 -
TLSVSVIICELTGQLSPILP Q18368 480 0 -
TVSLCVIFLELTNNLLLLPI P92942 524 1 -
TISLTVILIESTNEITYGLP CLC6_MOUSE 538 1 -
TISLTVILIESTNEITYGLP CLC6_HUMAN 537 1 -
TISTALLAFELTGQIVHALP CICK_HUMAN 481 0 -
SISTALLAFELTGQIVHALP CICK_RABIT 481 0 -
SISTALLAFELTGQIVHALP CICL_RABIT 481 0 -
TVSLCVIMVEITNNLKLLPL O81491 536 1 -
TVSLCVIMVEITNNLKLLPL P92943 523 1 -
TVSLCVIFLELTNNLLLLPI O64990 525 1 -
TVSLCVIFLELTNNLLLLPI Q96325 523 1 -
TVSLCVIFLELTNNLLLLPI P92941 525 1 -
TVSICVILLELTDDLLMLPL Q40485 535 1 -
TVTIVVIMFELTGALNFILP O60159 554 1 -
TISTALLAFELTGQIVHALP CICK_RAT 481 0 -
TLSLTVIMMEATSNVTYGFP O70496 561 1 -
TLSLTVIMMEATSNVTYGFP CLC7_RAT 561 1 -
TISLTAIIMEATKDITFGLP Q21791 561 1 -
TISTALLAFEVTGQIVHALP CICL_HUMAN 481 0 -
TVSVSVMIFEITGQLHFILP Q22270 489 0 -
TLSTALLAFEVSGQIVHALP CICL_RAT 481 0 -
TVSICVILLELTNNLLMLPL P93567 520 1 -
TVSLCVILLELTNNLLMLPL Q96282 535 1 -
SLSIALIVCETTGQLCALLP Q22833 535 0 -
TLTVVVIMFELTGAFMYIIP GEF1_YEAST 517 1 -
TICLAIIMFELTGSLEYMVP O60958 517 1 -

Motif 7 width=15
Element Seqn Id St Int Rpt
IYDAHIRLNGYPFLE CLC5_HUMAN 557 19 -
IYDAHIRLNGYPFLE CLC5_RAT 557 19 -
IYEAHIRLNGYPFLD CLC3_HUMAN 571 19 -
IYEAHIRLNGYPFLD O18894 629 19 -
IYEAHIRLNGYPFLD O14918 629 19 -
IYEAHIRLNGYPFLD CLC3_RAT 571 19 -
IYEAHIRLNGYPFLD CLC3_MOUSE 571 19 -
IYEAHIHLNGYPFLD CLC4_MOUSE 558 19 -
IYEAHIHLNGYPFLD CLC4_RAT 558 19 -
IYDAHIHLNGYPFLE O13080 619 19 -
IYEAHIHLNGYPFLD CLC4_HUMAN 571 19 -
LYDSIIRIKKLPYLP CLC2_HUMAN 552 18 -
LYDSIIRIKKLPYLP O54822 558 18 -
LYDSIIRIKKLPYLP O54821 558 18 -
LYDSIIRIKKLPYLP O14864 552 18 -
LYDSIIRIKKLPYLP CLC2_RAT 558 18 -
LYDSIIRIKKLPYLP CLC2_RABIT 555 18 -
IYEAHIRLNGYPSWD P97274 571 19 -
IYEAHIELNGYPFLD Q17804 539 19 -
IYDSIIRIKNLPYLP Q19067 484 18 -
LYDSIIQVKKLPYLP CLC1_RAT 577 18 -
LYDSIIQVKKLPYLP CLC1_HUMAN 577 18 -
LYDSIIQIKKLPYLP CICH_TORMA 511 18 -
LYDSIIQIKKLPYLP CICH_TORCA 510 18 -
IYESIIRVKKYPYLP Q18368 518 18 -
IYDIILHLKGLPFLE P92942 562 18 -
IYDVHIGLRGVPLLE CLC6_MOUSE 576 18 -
IYDIHVGLRGVPLLE CLC6_HUMAN 575 18 -
FYDGTIIVKKLPYLP CICK_HUMAN 519 18 -
FYDGTIMVKKLPYLP CICK_RABIT 519 18 -
FYDGTIMVKKLPYLP CICL_RABIT 519 18 -
LYEVQARLKGIPLLE O81491 574 18 -
LYEVQARLKGIPLLE P92943 561 18 -
IYEIILHLKGLPFLE O64990 563 18 -
IYEIILHLKGLPFLE Q96325 561 18 -
IYEIILHLKGLPFLE P92941 563 18 -
VYDQIVKMKGLPYLE Q40485 573 18 -
IADRSIEINGLPLLE O60159 593 19 -
FYDGTIMAKKLPYLP CICK_RAT 519 18 -
LYDMHIQLQSVPFLH O70496 599 18 -
LYDMHIQLQSVPFLH CLC7_RAT 599 18 -
LYDAHIDLAEVPILG Q21791 599 18 -
FYDGTVIVKKLPYLP CICL_HUMAN 519 18 -
FFDTIIKIKHLPFLP Q22270 527 18 -
FYDGTIIVKKLPYLP CICL_RAT 519 18 -
VYDQIVKMKGLPFLE P93567 558 18 -
VYDQIVTMKGLPYME Q96282 573 18 -
IYDSIIKINGYPYLA Q22833 573 18 -
IADQMIMVNGFPYLE GEF1_YEAST 557 20 -
TYEIGIEENKLPYLD O60958 556 19 -