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PR00543

Identifier
OESTROGENR  [View Relations]  [View Alignment]  
Accession
PR00543
No. of Motifs
8
Creation Date
08-JUN-1996  (UPDATE 08-JUL-2010)
Title
Oestrogen receptor signature
Database References
PRINTS; PR00398 STRDHORMONER
PFAM; PF02159 Oest_recep
INTERPRO; IPR001292
MIM; 133430; 601663
Literature References
1. NUCLEAR RECEPTORS NOMENCLATURE COMMITTEE
A unified nomenclature system for the nuclear receptor superfamily.
CELL 97 161-163 (1999).
 
2. NISHIKAWA, J-I., KITAURA, M., IMAGAWA, M. AND NISHIHARA, T.
Vitamin D receptor contains multiple dimerisation interfaces that
are functionally different.
NUCLEIC ACIDS RES. 23(4) 606-611 (1995).
 
3. DE VOS, P., SCHMITT, J., VERHOEVEN, G. AND STUNNENBERG, G.
Human androgen receptor expressed in HeLa cells activates transcription
in vitro.
NUCLEIC ACIDS RES. 22(7) 1161-1166 (1994).
 
4. DANIELIAN, P.S., WHITE, R., LEES, J.A. AND PARKER, M.G.
Identification of a conserved region required for hormone dependent
transcriptional activation by steroid hormone receptors.
EMBO J. 11 1025-1033 (1992).

Documentation
Steroid or nuclear hormone receptors (NRs) constitute an important super-
family of transcription regulators that are involved in widely diverse 
physiological functions, including control of embryonic development, cell
differentiation and homeostasis [1]. Members of the superfamily include the
steroid hormone receptors and receptors for thyroid hormone, retinoids, 
1,25-dihydroxy-vitamin D3 and a variety of other ligands. The proteins 
function as dimeric molecules in nuclei to regulate the transcription of 
target genes in a ligand-responsive manner [2,3]. In addition to C-terminal
ligand-binding domains, these nuclear receptors contain a highly-conserved,
N-terminal zinc-finger that mediates specific binding to target DNA 
sequences, termed ligand-responsive elements. In the absence of ligand,
steroid hormone receptors are thought to be weakly associated with nuclear
components; hormone binding greatly increases receptor affinity.
 
NRs are extremely important in medical research, a large number of them
being implicated in diseases such as cancer, diabetes, hormone resistance
syndromes, etc. [1]. While several NRs act as ligand-inducible transcription
factors, many do not yet have a defined ligand and are accordingly termed 
"orphan" receptors. During the last decade, more than 300 NRs have been
described, many of which are orphans, which cannot easily be named due to 
current nomenclature confusions in the literature. However, a new system 
has recently been introduced in an attempt to rationalise the increasingly 
complex set of names used to describe superfamily members [1].
 
The oestrogen receptor consists of 3 functional and structural domains:
an N-terminal (modulatory) domain; a DNA binding domain that mediates
specific binding to target DNA sequences, termed ligand-responsive
elements; and a hormone binding domain. The N-terminal domain is unique to
the oestrogen receptors and spans approximately the first 180 residues; the
highly-conserved DNA-binding domain is smaller (around 65 residues) and
occupies the central portion of the protein; and the hormone binding
domain lies at the receptor C-terminus. 
 
The oestrogen receptor [4] stimulates transcription via 2 distinct
transcriptional activation domains: TAF-1 in the N-terminal domain, and
TAF-2 in the hormone-binding domain. TAF-2 activity requires a region in
the C-terminus of the hormone-binding domain (between residues 538-552 in
the mouse oestrogen receptor) that is conserved in many nuclear hormone
receptors. It is therefore suggested that this region may be essential
for ligand-dependent transcriptional activation by other members of the
nuclear receptor family [3].
 
OESTROGENR is an 8-element fingerprint that provides a signature for the
oestrogen receptors. The fingerprint was derived from an initial alignment
of 4 sequences: the motifs span the N-terminal modulatory domain preceding
the highly-conserved zinc-binding region shared by the steroid hormone
receptor family. Two iterations on OWL28.0 were required to reach
convergence, at which point a true set comprising 8 sequences was
identified. A single partial match was also found (ORZMER), an oestrogen
receptor from the killifish that matches motifs 5 and 6.
 
An update on SPTR57.15_40.15f identified a true set of 46 sequences,
together with numerous partial matches, all of which are family members
that fail to match one or more motifs.
Summary Information
  46 codes involving  8 elements
3 codes involving 7 elements
3 codes involving 6 elements
2 codes involving 5 elements
2 codes involving 4 elements
0 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
84646464646464646
733333330
621312333
510012222
411002211
300000000
200000110
12345678
True Positives
A2TEV4_PIG    A8KAF4_HUMAN  A8QZK3_9SAUR  A8VFJ8_PLEWA  
B2NIY0_XENLA B2NIY1_XENLA B3VQI7_MOUSE B6CK15_PANPA
B6CK16_9PRIM B6CK17_PONPY B6CK18_HYLLA B6CK19_PAPAN
B6CK20_CERAE B6CK21_COLGU B6CK22_TRAOB B6CK23_ATEPA
B6CK24_CEBAP B6CZ21_9SAUR B6E1V9_9SAUR B6ZGU3_HUMAN
B6ZK18_9FALC B6ZK19_TORTR D0FYH4_RAT ESR1_BOVIN
ESR1_FELCA ESR1_HORSE ESR1_MESAU ESTR_CHICK
ESTR_HUMAN ESTR_MOUSE ESTR_PIG ESTR_RAT
P81559 Q0KKA1_9AMPH Q14267 Q14268
Q1EDB6_MICOH Q25C14_XENTR Q3LGB2_CRONI Q3UT58_MOUSE
Q5T5H7_HUMAN Q6W5G7_XENLA Q765N7_ALLMI Q8AYH0_COTJA
Q8UWB0_CAICR Q91250
True Positive Partials
Codes involving 7 elements
Q8UWA9_CNEUN Q9H2M1_HUMAN Q9H2M2_HUMAN
Codes involving 6 elements
B6F0Z4_PRODO B6F101_PROAN Q2HWK5_EUBMA
Codes involving 5 elements
B4E3R5_HUMAN Q6W5G9_XENTR
Codes involving 4 elements
B6F0Z7_ACISC B6F0Z9_9ACTI
Codes involving 2 elements
B6F0Z6_ACISC
Sequence Titles
A2TEV4_PIG  Estrogen receptor alpha - Sus scrofa          
A8KAF4_HUMAN cDNA FLJ77952, highly similar to Homo sapiens oestrogen receptor - Homo sapiens
A8QZK3_9SAUR Estrogen receptor alpha - Pseudemys nelsoni
A8VFJ8_PLEWA Estrogen receptor alpha - Pleurodeles waltlii
B2NIY0_XENLA Brain estrogen receptor alpha1 - Xenopus laevis
B2NIY1_XENLA Brain estrogen receptor alpha2 - Xenopus laevis
B3VQI7_MOUSE Estrogen receptor alpha variant U1 - Mus musculus
B6CK15_PANPA Estrogen receptor alpha - Pan paniscus
B6CK16_9PRIM Estrogen receptor alpha - Gorilla gorilla
B6CK17_PONPY Estrogen receptor alpha - Pongo pygmaeus
B6CK18_HYLLA Estrogen receptor alpha - Hylobates lar
B6CK19_PAPAN Estrogen receptor alpha - Papio anubis
B6CK20_CERAE Estrogen receptor alpha - Cercopithecus aethiops
B6CK21_COLGU Estrogen receptor alpha - Colobus guereza
B6CK22_TRAOB Estrogen receptor alpha - Trachypithecus obscurus
B6CK23_ATEPA Estrogen receptor alpha - Ateles paniscus
B6CK24_CEBAP Estrogen receptor alpha - Cebus apella
B6CZ21_9SAUR Estrogen receptor alpha - Lepidochelys olivacea
B6E1V9_9SAUR Estrogen receptor - Chrysemys picta
B6ZGU3_HUMAN Estrogen receptor 1 - Homo sapiens
B6ZK18_9FALC Estrogen receptor alpha - Gyps africanus
B6ZK19_TORTR Estrogen receptor alpha - Torgos tracheliotus
D0FYH4_RAT Estrogen receptor alpha - Rattus norvegicus
ESR1_BOVIN Estrogen receptor - Bos taurus
ESR1_FELCA Estrogen receptor - Felis catus
ESR1_HORSE Estrogen receptor - Equus caballus
ESR1_MESAU Estrogen receptor - Mesocricetus auratus
ESTR_CHICK ESTROGEN RECEPTOR (ER) (ESTRADIOL RECEPTOR) - GALLUS GALLUS (CHICKEN).
ESTR_HUMAN ESTROGEN RECEPTOR (ER) (ESTRADIOL RECEPTOR) - HOMO SAPIENS (HUMAN).
ESTR_MOUSE ESTROGEN RECEPTOR (ER) (ESTRADIOL RECEPTOR) - MUS MUSCULUS (MOUSE).
ESTR_PIG ESTROGEN RECEPTOR (ER) (ESTRADIOL RECEPTOR) - SUS SCROFA (PIG).
ESTR_RAT ESTROGEN RECEPTOR (ER) (ESTRADIOL RECEPTOR) - RATTUS NORVEGICUS (RAT).
P81559 ESTROGEN RECEPTOR (ER) (ESTRADIOL RECEPTOR) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q0KKA1_9AMPH Estrogen receptor alpha - Andrias japonicus
Q14267 ESTROGEN RECEPTOR-RELATED PROTEIN - HOMO SAPIENS (HUMAN).
Q14268 ESTROGEN RECEPTOR-RELATED PROTEIN - HOMO SAPIENS (HUMAN).
Q1EDB6_MICOH Estrogen receptor alpha - Microtus ochrogaster
Q25C14_XENTR Estrogen receptor alpha - Xenopus tropicalis
Q3LGB2_CRONI Estrogen receptor alpha - Crocodylus niloticus
Q3UT58_MOUSE Putative uncharacterized protein - Mus musculus
Q5T5H7_HUMAN Estrogen receptor 1 - Homo sapiens
Q6W5G7_XENLA Estrogen receptor alpha 1 - Xenopus laevis
Q765N7_ALLMI Estrogen receptor a - Alligator mississippiensis
Q8AYH0_COTJA Estrogen receptor alpha - Coturnix coturnix japonica
Q8UWB0_CAICR Estrogen receptor - Caiman crocodilus
Q91250 ESTROGEN RECEPTOR (ER) (ESTRADIOL RECEPTOR) - POEPHILA GUTTATA (ZEBRA FINCH) (TAENIOPYGIA GUTTATA).

Q8UWA9_CNEUN Estrogen receptor - Cnemidophorus uniparens
Q9H2M1_HUMAN Estrogen receptor 1 - Homo sapiens
Q9H2M2_HUMAN Estrogen receptor alpha - Homo sapiens

B6F0Z4_PRODO Estrogen receptor alpha - Protopterus dolloi
B6F101_PROAN Estrogen receptor alpha - Protopterus annectens
Q2HWK5_EUBMA Estrogen receptor alpha - Eublepharis macularius

B4E3R5_HUMAN cDNA FLJ51616, highly similar to Estrogen receptor - Homo sapiens
Q6W5G9_XENTR Estrogen receptor alpha - Xenopus tropicalis

B6F0Z7_ACISC Estrogen receptor alpha2 - Acipenser schrenckii
B6F0Z9_9ACTI Estrogen receptor alpha - Atractosteus tropicus

B6F0Z6_ACISC Estrogen receptor alpha1 - Acipenser schrenckii
Scan History
OWL28_0    2  100  NSINGLE    
SPTR37_9f 2 11 NSINGLE
SPTR57.15_40.15f 3 300 NSINGLE
Initial Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
HTKASGMALLHQIQGNELE ESTR_HUMAN 6 6 -
HTKASGMALLHQIQGNELE ESTR_MOUSE 6 6 -
HTKASGMALLHQIQGNELE ESTR_RAT 6 6 -
HTKASGVTLLHQIQGTELE ESTR_CHICK 6 6 -

Motif 2 width=18
Element Seqn Id St Int Rpt
LNRPQLKIPLERPLGEVY ESTR_HUMAN 26 1 -
LNRPQLKMPMERALGEVY ESTR_MOUSE 26 1 -
LNRPQLKMPMERALGEVY ESTR_RAT 26 1 -
LSRPQLKIPLERSLSDMY ESTR_CHICK 26 1 -

Motif 3 width=18
Element Seqn Id St Int Rpt
DSSKPAVYNYPEGAAYEF ESTR_HUMAN 45 1 -
DNSKPTVFNYPEGAAYEF ESTR_MOUSE 45 1 -
DNSKPAVFNYPEGAAYEF ESTR_RAT 45 1 -
ESNKTGVFNYPEGATYDF ESTR_CHICK 45 1 -

Motif 4 width=16
Element Seqn Id St Int Rpt
AQVYGQTGLPYGPGSE ESTR_HUMAN 70 7 -
APVYGQSGIAYGPGSE ESTR_MOUSE 74 11 -
APVYGQSSITYGPGSE ESTR_RAT 75 12 -
APVYGSTTLSYAPTSE ESTR_CHICK 66 3 -

Motif 5 width=15
Element Seqn Id St Int Rpt
FPPLNSVSPSPLMLL ESTR_HUMAN 97 11 -
FPQLNSVSPSPLMLL ESTR_MOUSE 101 11 -
FPQLNSVSPSPLMLL ESTR_RAT 102 11 -
FHSLNNVPPSPVVFL ESTR_CHICK 91 9 -

Motif 6 width=17
Element Seqn Id St Int Rpt
PQLSPFLQPHGQQVPYY ESTR_HUMAN 115 3 -
PQLSPFLHPHGQQVPYY ESTR_MOUSE 119 3 -
PHVSPFLHPHGHQVPYY ESTR_RAT 120 3 -
PQLSPFIHHHSQQVPYY ESTR_CHICK 109 3 -

Motif 7 width=20
Element Seqn Id St Int Rpt
LENEPSGYTVREAGPPAFYR ESTR_HUMAN 132 0 -
LENEPSAYAVRDTGPPAFYR ESTR_MOUSE 136 0 -
LENEPSAYAVRDTGPPAFYR ESTR_RAT 137 0 -
LENEQGSFGMREAAPPAFYR ESTR_CHICK 126 0 -

Motif 8 width=20
Element Seqn Id St Int Rpt
NSDNRRQGGRERLASTNDKG ESTR_HUMAN 153 1 -
NSDNRRQNGRERLSSSNEKG ESTR_MOUSE 157 1 -
NSDNRRQNGRERLSSSSEKG ESTR_RAT 158 1 -
SSDNRRHSIRERMSSTNEKG ESTR_CHICK 147 1 -
Final Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
HTKASGMALLHQIQGNELE A8KAF4_HUMAN 6 6 -
HTKASGMALLHQIQGNELE Q5T5H7_HUMAN 6 6 -
HTKASGMALLHQIQGNELE Q14268 6 6 -
HTKASGMALLHQIQGNELE Q14267 6 6 -
HTKASGMALLHQIQGNELE ESTR_HUMAN 6 6 -
HTKASGMALLHQIQGNELE B6ZGU3_HUMAN 6 6 -
HTKASGMALLHQIQGNELE B6CK22_TRAOB 6 6 -
HTKASGMALLHQIQGNELE B6CK20_CERAE 6 6 -
HTKASGMALLHQIQGNELE B6CK18_HYLLA 6 6 -
HTKASGMALLHQIQGNELE B6CK17_PONPY 6 6 -
HTKASGMALLHQIQGNELE B6CK16_9PRIM 6 6 -
HTKASGMALLHQIQGNELE B6CK15_PANPA 6 6 -
HTKASGMALLHQIQGNELE B6CK21_COLGU 6 6 -
HTKASGMALLHQIQGNELE B6CK19_PAPAN 6 6 -
HTKASGMALLHQIQANELE A2TEV4_PIG 6 6 -
HTKASGMALLHQIQANELE ESTR_PIG 6 6 -
HTKASGMALLHQIQGNELE B6CK23_ATEPA 6 6 -
HTKASGMALLHQIQGNELE B6CK24_CEBAP 6 6 -
HTKASGMALLHQIQGNELE ESR1_FELCA 6 6 -
HTKASGMALLHQIQANELE ESR1_BOVIN 6 6 -
HTKASGMALLHQIQGNELE B3VQI7_MOUSE 6 6 -
HTKASGMALLHQIQGNELE Q3UT58_MOUSE 6 6 -
HTKASGMALLHQIQGNELE ESTR_MOUSE 6 6 -
HTKASGMALLHQIQGNELE ESR1_MESAU 6 6 -
HTKASGMALLHQIQGNELE D0FYH4_RAT 6 6 -
HTKASGMALLHQIQGNELE ESTR_RAT 6 6 -
HTKASGMALLHQIQGNELE ESR1_HORSE 6 6 -
HTKTSGVALLHQIQGTELE A8QZK3_9SAUR 6 6 -
HTKTSGVALLHQIQGTELE B6E1V9_9SAUR 6 6 -
HTKASGVTLLHQIQGTELE ESTR_CHICK 6 6 -
HTKTSGVTLLHQIQGTELE B6ZK18_9FALC 4 4 -
HTKTSGVTLLHQIQGTELE B6ZK19_TORTR 4 4 -
HTKASGMALLHQIQGNELE Q1EDB6_MICOH 6 6 -
HTKASGVTLLHQIQGTELE Q8AYH0_COTJA 6 6 -
HTKNSGVALLHQIQSTELE B6CZ21_9SAUR 6 6 -
HTKTSGVTLLHQIQGTELE Q3LGB2_CRONI 6 6 -
HTKTSGVTLLHQIQGTELE Q91250 4 4 -
HTKTSGVTLLHQIQGTELE Q765N7_ALLMI 6 6 -
HNKTTGVTLLHQIQSSELE B2NIY0_XENLA 6 6 -
HNKTTGVTLLHQIQSSELE B2NIY1_XENLA 6 6 -
HTKTSGVTLLHQIQGTELE Q8UWB0_CAICR 6 6 -
HNKTTGVTLLHQIQSSELE Q25C14_XENTR 6 6 -
PNKTTGVTFLHQIQSSELE P81559 6 6 -
PNKTTGVTFLHQIQSSELE Q6W5G7_XENLA 6 6 -
HSKIPGVTLLHQIQATELE Q0KKA1_9AMPH 4 4 -
HSKTPGVALLHQIQATELE A8VFJ8_PLEWA 4 4 -

Motif 2 width=18
Element Seqn Id St Int Rpt
LNRPQLKIPLERPLGEVY A8KAF4_HUMAN 26 1 -
LNRPQLKIPLERPLGEVY Q5T5H7_HUMAN 26 1 -
LNRPQLKIPLERPLGEVY Q14268 26 1 -
LNRPQLKIPLERPLGEVY Q14267 26 1 -
LNRPQLKIPLERPLGEVY ESTR_HUMAN 26 1 -
LNRPQLKIPLERPLGEVY B6ZGU3_HUMAN 26 1 -
LNRPQLKIPLERPLGEVY B6CK22_TRAOB 26 1 -
LNRPQLKIPLERPLGEVY B6CK20_CERAE 26 1 -
LNRPQLKIPLERPLGEVY B6CK18_HYLLA 26 1 -
LNRPQLKIPLERPLGEVY B6CK17_PONPY 26 1 -
LNRPQLKIPLERPLGEVY B6CK16_9PRIM 26 1 -
LNRPQLKIPLERPLGEVY B6CK15_PANPA 26 1 -
LNRPQLKIPLERPLGEVY B6CK21_COLGU 26 1 -
LNRPQLKIPLERPLGEVY B6CK19_PAPAN 26 1 -
LNRPQLKIPLERPLGEVY A2TEV4_PIG 26 1 -
LNRPQLKIPLERPLGEVY ESTR_PIG 26 1 -
LNRPQLKIPLERPLGEVY B6CK23_ATEPA 26 1 -
LNRPQLKIPLERPLGEVY B6CK24_CEBAP 26 1 -
LNRPQLKIPLERPLGEVY ESR1_FELCA 26 1 -
LNRPQLKIPLERPLGEVY ESR1_BOVIN 26 1 -
LNRPQLKMPMERALGEVY B3VQI7_MOUSE 26 1 -
LNRPQLKMPMERALGEVY Q3UT58_MOUSE 26 1 -
LNRPQLKMPMERALGEVY ESTR_MOUSE 26 1 -
LSRPQLKMPLERALSEVY ESR1_MESAU 26 1 -
LNRPQLKMPMERALGEVY D0FYH4_RAT 26 1 -
LNRPQLKMPMERALGEVY ESTR_RAT 26 1 -
LNLPQFKIPLERPLGEVY ESR1_HORSE 26 1 -
LSRPQLKIPLDRSLSEMY A8QZK3_9SAUR 26 1 -
LSRPQLKIPLDRSLSEMY B6E1V9_9SAUR 26 1 -
LSRPQLKIPLERSLSDMY ESTR_CHICK 26 1 -
LSRPQLKIPLERSLSDMY B6ZK18_9FALC 24 1 -
LSRPQLKIPLERSLSDMY B6ZK19_TORTR 24 1 -
LNRPQLKMPLERALGEVY Q1EDB6_MICOH 26 1 -
LSRPQLKIPLERSLSDMY Q8AYH0_COTJA 26 1 -
LSRPQLKIPLDRSLSEMY B6CZ21_9SAUR 26 1 -
LSRPQLKIPLDRSLTEMY Q3LGB2_CRONI 26 1 -
LSRPQLKIPLERSLSDMY Q91250 24 1 -
LSRPQLKIPLDRSLSEMY Q765N7_ALLMI 26 1 -
LSRPPLKIPLERPLGEMC B2NIY0_XENLA 26 1 -
LSRPPLKIPLERPLGEMC B2NIY1_XENLA 26 1 -
LSRPQLKIPLDRSLSEMY Q8UWB0_CAICR 26 1 -
LSRPPLKIPLERPLSEMY Q25C14_XENTR 26 1 -
LTRPPLKISLERPLGEMY P81559 26 1 -
LTRPPLKISLERPLGEMY Q6W5G7_XENLA 26 1 -
LGRPALKIPLDRPLSDMY Q0KKA1_9AMPH 24 1 -
RGRPPLKLPLDRSLGEMY A8VFJ8_PLEWA 24 1 -

Motif 3 width=18
Element Seqn Id St Int Rpt
DSSKPAVYNYPEGAAYEF A8KAF4_HUMAN 45 1 -
DSSKPAVYNYPEGAAYEF Q5T5H7_HUMAN 45 1 -
DSSKPAVYNYPEGAAYEF Q14268 45 1 -
DSSKPAVYNYPEGAAYEF Q14267 45 1 -
DSSKPAVYNYPEGAAYEF ESTR_HUMAN 45 1 -
DSSKPAVYNYPEGAAYEF B6ZGU3_HUMAN 45 1 -
DSSKPAVYNYPEGAAYEF B6CK22_TRAOB 45 1 -
DSSKPAVYNYPEGAAYEF B6CK20_CERAE 45 1 -
DSSKPAVYNYPEGAAYEF B6CK18_HYLLA 45 1 -
DSSKPAVYNYPEGAAYEF B6CK17_PONPY 45 1 -
DSSKPAVYNYPEGAAYEF B6CK16_9PRIM 45 1 -
NSSKPAVYNYPEGAAYEF B6CK15_PANPA 45 1 -
DSSKPAVYNYPEGAAYEF B6CK21_COLGU 45 1 -
DSSKPAVYSYPEGAAYEF B6CK19_PAPAN 45 1 -
DSSKPAVYNYPEGAAYDF A2TEV4_PIG 45 1 -
DSSKPAVYNYPEGAAYDF ESTR_PIG 45 1 -
DSSKPAVYNYPEGAAYEF B6CK23_ATEPA 45 1 -
DSSKPAVYNYPEGAAYEF B6CK24_CEBAP 45 1 -
DGSKPAVYNYPEGAAYDF ESR1_FELCA 45 1 -
DSSKPAVYNYPEGAAYDF ESR1_BOVIN 45 1 -
DNSKPTVFNYPEGAAYEF B3VQI7_MOUSE 45 1 -
DNSKPTVFNYPEGAAYEF Q3UT58_MOUSE 45 1 -
DNSKPTVFNYPEGAAYEF ESTR_MOUSE 45 1 -
DSSKPAMFNYPEGAAYEF ESR1_MESAU 45 1 -
DNSKPAVFNYPEGAAYEF D0FYH4_RAT 45 1 -
DNSKPAVFNYPEGAAYEF ESTR_RAT 45 1 -
ESSKPPVYDYPEGAAYDF ESR1_HORSE 45 1 -
ESNKTGVFNYPEGTTYDF A8QZK3_9SAUR 45 1 -
ESNKTGVFNYPEGTTYDF B6E1V9_9SAUR 45 1 -
ESNKTGVFNYPEGATYDF ESTR_CHICK 45 1 -
ESNKTGVFNYPEGATYDF B6ZK18_9FALC 43 1 -
ESNKTGVFNYPEGATYDF B6ZK19_TORTR 43 1 -
DGSKPAVFNYPESAAYEF Q1EDB6_MICOH 45 1 -
ESNKTGVFNYPEGATYDF Q8AYH0_COTJA 45 1 -
ESNKTGVFNYPEGTTYDF B6CZ21_9SAUR 45 1 -
ESNKTGIFNYPEGTTYDF Q3LGB2_CRONI 45 1 -
ETNKTGVFNYPEGATYDF Q91250 43 1 -
ESNKTGIFNYPEGTTYDF Q765N7_ALLMI 45 1 -
ENNRTGIFNYPEGTTYDF B2NIY0_XENLA 45 1 -
ENNRTGIFNYPEGTTYDF B2NIY1_XENLA 45 1 -
ENNKTGIFNYPEGTTYDF Q8UWB0_CAICR 45 1 -
ENNRTGIFNYPEGTTYDF Q25C14_XENTR 45 1 -
ENNRTGIFNYPEGTTYDF P81559 45 1 -
ENNRTGIFNYPEGTTYDF Q6W5G7_XENLA 45 1 -
ENNRTGIFNYSEGATFDF Q0KKA1_9AMPH 43 1 -
ENSRTGIFSYPEGTTYEF A8VFJ8_PLEWA 43 1 -

Motif 4 width=16
Element Seqn Id St Int Rpt
AQVYGQTGLPYGPGSE A8KAF4_HUMAN 70 7 -
AQVYGQTGLPYGPGSE Q5T5H7_HUMAN 70 7 -
AQVYGQTGLPYGPGSE Q14268 70 7 -
AQVYGQTGLPYGPGSE Q14267 70 7 -
AQVYGQTGLPYGPGSE ESTR_HUMAN 70 7 -
AQVYGQTGLPYGPGSE B6ZGU3_HUMAN 70 7 -
AQVYGQTGLPYGPGSE B6CK22_TRAOB 70 7 -
AQVYGQTGLPYGPGSE B6CK20_CERAE 70 7 -
AQVYGQTGLPYGPGSE B6CK18_HYLLA 70 7 -
AQVYGQTGLPYGPGSE B6CK17_PONPY 70 7 -
AQVYGQTGLPYGPGSE B6CK16_9PRIM 70 7 -
AQVYGQTGLPYGPGSE B6CK15_PANPA 70 7 -
AQVYGQTGLPYGPGSE B6CK21_COLGU 70 7 -
AQVYGQTGLPYGPGSE B6CK19_PAPAN 70 7 -
APVYGQSGLAYGPGSE A2TEV4_PIG 70 7 -
APVYGQSGLAYGPGSE ESTR_PIG 70 7 -
AQVYGQSGLPYGPGSE B6CK23_ATEPA 70 7 -
AQVYGQSGLPYGPGSE B6CK24_CEBAP 70 7 -
APVYGQSGLAYGSGSE ESR1_FELCA 70 7 -
APVYGQSGLPYGPGSE ESR1_BOVIN 70 7 -
APVYGQSGIAYGPGSE B3VQI7_MOUSE 71 8 -
APVYGQSGIAYGPGSE Q3UT58_MOUSE 74 11 -
APVYGQSGIAYGPGSE ESTR_MOUSE 74 11 -
APVYGQTGIAYGSGSE ESR1_MESAU 69 6 -
APVYGQSSITYGPGSE D0FYH4_RAT 75 12 -
APVYGQSSITYGPGSE ESTR_RAT 75 12 -
ASVYGQSGLAYGPGSE ESR1_HORSE 70 7 -
APVYSSTSLSYAPASE A8QZK3_9SAUR 66 3 -
APVYSSTSLSYAPASE B6E1V9_9SAUR 66 3 -
APVYGSTTLSYAPTSE ESTR_CHICK 66 3 -
APVYSSTTLSYAPTSE B6ZK18_9FALC 64 3 -
APVYSSTTLSYAPTSE B6ZK19_TORTR 64 3 -
APVYGQSGIAYGPGSE Q1EDB6_MICOH 72 9 -
APVYGSTTLSYAPTSE Q8AYH0_COTJA 66 3 -
APVYSSTSLSYAPASE B6CZ21_9SAUR 66 3 -
APVYSSTSLSYAPTSE Q3LGB2_CRONI 66 3 -
APVYSSTTLSYAPTSE Q91250 64 3 -
APVYSSTSLSYAPTSE Q765N7_ALLMI 66 3 -
APVYSSASLSYAPSSE B2NIY0_XENLA 67 4 -
APVYSSASLSYAPSSE B2NIY1_XENLA 67 4 -
APVYSSTSLSYAPTSE Q8UWB0_CAICR 66 3 -
APVYSSASLSYAASSE Q25C14_XENTR 67 4 -
APVYSSASLSYAASSE P81559 67 4 -
APVYSSASLSYAASSE Q6W5G7_XENLA 67 4 -
APIYSSASLNYAASSE Q0KKA1_9AMPH 65 4 -
APIYSSASLSYAASSD A8VFJ8_PLEWA 65 4 -

Motif 5 width=15
Element Seqn Id St Int Rpt
FPPLNSVSPSPLMLL A8KAF4_HUMAN 97 11 -
FPPLNSVSPSPLMLL Q5T5H7_HUMAN 97 11 -
FPPLNSVSPSPLMLL Q14268 97 11 -
FPPLNSVSPSPLMLL Q14267 97 11 -
FPPLNSVSPSPLMLL ESTR_HUMAN 97 11 -
FPPLNSVSPSPLMLL B6ZGU3_HUMAN 97 11 -
FPPLNSVSPSPLMLL B6CK22_TRAOB 97 11 -
FPPLNSVSPSPLMLL B6CK20_CERAE 97 11 -
FPPLNSVSPSPLMLL B6CK18_HYLLA 97 11 -
FPPLNSVSPSPLMLL B6CK17_PONPY 97 11 -
FPPLNSVSPSPLMLL B6CK16_9PRIM 97 11 -
FPPLNSVSPSPLMLL B6CK15_PANPA 97 11 -
FPPLNSVSPSPLMLL B6CK21_COLGU 97 11 -
FPPLNSVSPSPLMLL B6CK19_PAPAN 97 11 -
FQPLNSVSPSPLVLL A2TEV4_PIG 97 11 -
FQPLNSVSPSPLVLL ESTR_PIG 97 11 -
FPPLNSVSPSPLMLL B6CK23_ATEPA 97 11 -
FPTLNSVSPSQLMLL B6CK24_CEBAP 97 11 -
FPPLNSVSPSPLVLL ESR1_FELCA 97 11 -
FPPLNSVSPSPLVLL ESR1_BOVIN 97 11 -
FPQLNSVSPSPLMLL B3VQI7_MOUSE 98 11 -
FPQLNSVSPSPLMLL Q3UT58_MOUSE 101 11 -
FPQLNSVSPSPLMLL ESTR_MOUSE 101 11 -
FPQLNSVSPSPLMLL ESR1_MESAU 96 11 -
FPQLNSVSPSPLMLL D0FYH4_RAT 102 11 -
FPQLNSVSPSPLMLL ESTR_RAT 102 11 -
FPPLNSVSPSQLMLL ESR1_HORSE 97 11 -
FHSLNNVPPSPVVFL A8QZK3_9SAUR 91 9 -
FHSLNNVPPSPVVFL B6E1V9_9SAUR 91 9 -
FHSLNNVPPSPVVFL ESTR_CHICK 91 9 -
FHSLNNVPPSPVVFL B6ZK18_9FALC 89 9 -
FHSLNNVPPSPVVFL B6ZK19_TORTR 89 9 -
FPQLNSVSPSPLMLL Q1EDB6_MICOH 99 11 -
FHSLNNVPPSPVVFL Q8AYH0_COTJA 91 9 -
FHSLNNVPPSPMVFL B6CZ21_9SAUR 91 9 -
FHSLNNVPPSPVVFL Q3LGB2_CRONI 91 9 -
FHSLNSVPPSPVVFL Q91250 89 9 -
FHSLNNVPPSPVVFL Q765N7_ALLMI 91 9 -
LHTLNNVPPSPVVFL B2NIY0_XENLA 92 9 -
LHTLNNVPPSPVVFL B2NIY1_XENLA 92 9 -
FHSLNNVPPSPVVFL Q8UWB0_CAICR 91 9 -
LHTLNNVPPSPVVFL Q25C14_XENTR 92 9 -
LHTLNNVPPSPVVFL P81559 92 9 -
LHTLNNVPPSPVVFL Q6W5G7_XENLA 92 9 -
LHSLNSVPPSPVVFL Q0KKA1_9AMPH 90 9 -
LHSLNSVPPSPVVFL A8VFJ8_PLEWA 90 9 -

Motif 6 width=17
Element Seqn Id St Int Rpt
PQLSPFLQPHGQQVPYY A8KAF4_HUMAN 115 3 -
PQLSPFLQPHGQQVPYY Q5T5H7_HUMAN 115 3 -
PQLSPFLQPHGQQVPYY Q14268 115 3 -
PQLSPFLQPHGQQVPYY Q14267 115 3 -
PQLSPFLQPHGQQVPYY ESTR_HUMAN 115 3 -
PQLSPFLQPHGQQVPYY B6ZGU3_HUMAN 115 3 -
PQLSPFLQPHGQQVPYY B6CK22_TRAOB 115 3 -
PQLSPFLQPHGQQVPYY B6CK20_CERAE 115 3 -
PQLSPFLQPHGQQVPYY B6CK18_HYLLA 115 3 -
PQLSPFLQPHGQQVPYY B6CK17_PONPY 115 3 -
PQLSPFLQPHGQQVPYY B6CK16_9PRIM 115 3 -
PQLSPFLQPHGQQVPYY B6CK15_PANPA 115 3 -
PQLSPFLQPHGQQVPYY B6CK21_COLGU 115 3 -
PQLSPFLQPHGQQVPYY B6CK19_PAPAN 115 3 -
PQLSPFLHPHGQQVPYY A2TEV4_PIG 115 3 -
PQLSPFLHPHGQQVPYY ESTR_PIG 115 3 -
PQLSPFLQPHGQQVPYY B6CK23_ATEPA 115 3 -
PQLSPFLQPHGQQVPYY B6CK24_CEBAP 115 3 -
PQLSPFLHPHGQQVPYY ESR1_FELCA 115 3 -
QPLSPFLHPHGQQVPYY ESR1_BOVIN 116 4 -
PQLSPFLHPHGQQVPYY B3VQI7_MOUSE 116 3 -
PQLSPFLHPHGQQVPYY Q3UT58_MOUSE 119 3 -
PQLSPFLHPHGQQVPYY ESTR_MOUSE 119 3 -
PQLSPFLHPHGQQVPYY ESR1_MESAU 115 4 -
PQLSPFLHPHGHQVPYY D0FYH4_RAT 120 3 -
PHVSPFLHPHGHQVPYY ESTR_RAT 120 3 -
PQLSPYLHPPGQQVPYY ESR1_HORSE 115 3 -
PQLSPFIHHHSQQVPYY A8QZK3_9SAUR 109 3 -
PQLSPFIHHHSQQVPYY B6E1V9_9SAUR 109 3 -
PQLSPFIHHHSQQVPYY ESTR_CHICK 109 3 -
PQLSPFIHHHSQQVPYY B6ZK18_9FALC 107 3 -
PQLSPFIHHHSQQVPYY B6ZK19_TORTR 107 3 -
PQLSPFLHPHGQQVPYY Q1EDB6_MICOH 118 4 -
PQLSPFIHHHSQQVPYY Q8AYH0_COTJA 109 3 -
PQLSPFIHHHSQQVPYY B6CZ21_9SAUR 109 3 -
PQLSPFIHHHSQQVPYY Q3LGB2_CRONI 109 3 -
PHWSPFIHHHSQQVPYY Q91250 107 3 -
PQLSPFIHHHSQQVPYY Q765N7_ALLMI 109 3 -
PQLSPFIHHHGQQVPYY B2NIY0_XENLA 109 2 -
PQLSPFIHHHGQQVPYY B2NIY1_XENLA 109 2 -
PQLSPFVHHHSQQVPYY Q8UWB0_CAICR 109 3 -
PQLSPFIHHHGQQVPYY Q25C14_XENTR 109 2 -
PQLSPFIHHHGQQVPYY P81559 110 3 -
PQLSPFIHHHGQQVPYY Q6W5G7_XENLA 109 2 -
PQLSPFIHHHGQQVPYY Q0KKA1_9AMPH 108 3 -
PQLSPFIHHHGQQVPYY A8VFJ8_PLEWA 108 3 -

Motif 7 width=20
Element Seqn Id St Int Rpt
LENEPSGYTVREAGPPAFYR A8KAF4_HUMAN 132 0 -
LENEPSGYTVREAGPPAFYR Q5T5H7_HUMAN 132 0 -
LENEPSGYTVREAGPPAFYR Q14268 132 0 -
LENEPSGYTVREAGPPAFYR Q14267 132 0 -
LENEPSGYTVREAGPPAFYR ESTR_HUMAN 132 0 -
LENEPSGYTVREAGPPAFYR B6ZGU3_HUMAN 132 0 -
LENEPSGYTVREAGPPAFYR B6CK22_TRAOB 132 0 -
LENEPSGYTVREAGPPAFYR B6CK20_CERAE 132 0 -
LENEPSGYTVREAGPPAFYR B6CK18_HYLLA 132 0 -
LENEPSGYTVREAGPPAFYR B6CK17_PONPY 132 0 -
LENEPSGYTVREAGPPAFYR B6CK16_9PRIM 132 0 -
LENEPSGYTVREAGPPAFYR B6CK15_PANPA 132 0 -
LENEPSGYTVREAGQPAFYR B6CK21_COLGU 132 0 -
LENEPSGYTVREAGPPAFYR B6CK19_PAPAN 132 0 -
LENEPSGYAVREAGPPAFYR A2TEV4_PIG 132 0 -
LENEPSGYAVREAGPPAFYR ESTR_PIG 132 0 -
LENEPSGYTVREAGQPAFYR B6CK23_ATEPA 132 0 -
LENEPSGYTVREAGPPAFYR B6CK24_CEBAP 132 0 -
LENEPSGYAVREAGPPAFYR ESR1_FELCA 132 0 -
LENESSGYAVREAGPPAYYR ESR1_BOVIN 133 0 -
LENEPSAYAVRDTGPPAFYR B3VQI7_MOUSE 133 0 -
LENEPSAYAVRDTGPPAFYR Q3UT58_MOUSE 136 0 -
LENEPSAYAVRDTGPPAFYR ESTR_MOUSE 136 0 -
LENEPSAYAVRDSGPPAFYR ESR1_MESAU 132 0 -
LENEPSAYAVRDTGPPAFYR D0FYH4_RAT 137 0 -
LENEPSAYAVRDTGPPAFYR ESTR_RAT 137 0 -
LENEPSGYSVCEAGPQAFYR ESR1_HORSE 132 0 -
LENDQSSFGMREAGPPAFYR A8QZK3_9SAUR 126 0 -
LENDQSSFGMREAGPPAFYR B6E1V9_9SAUR 126 0 -
LENEQGSFGMREAAPPAFYR ESTR_CHICK 126 0 -
LENEQGSFGMREAAPPAFYR B6ZK18_9FALC 124 0 -
LENEQGSFGMREAAPPAFYR B6ZK19_TORTR 124 0 -
ENEPSAYAAVRDPGPPAFYR Q1EDB6_MICOH 136 1 -
LENEQGSFGMRETAPPAFYR Q8AYH0_COTJA 126 0 -
LENDQSSFGMREAGPPTFYR B6CZ21_9SAUR 126 0 -
LENDQSGFGMREAAPPTFYR Q3LGB2_CRONI 126 0 -
LENDQGSFGMREAAPPAFYR Q91250 124 0 -
LENDQSGFGMREAAPSTFYR Q765N7_ALLMI 126 0 -
LESEQGTFAVREAPPPTFYR B2NIY0_XENLA 126 0 -
LESEQGTFAVREAPPPTFYR B2NIY1_XENLA 126 0 -
LENDQSGFGMREAASSTFYR Q8UWB0_CAICR 126 0 -
LESEQGTFAVREAAPPTFYR Q25C14_XENTR 126 0 -
LESEQGTFAVREAAPPTFYR P81559 127 0 -
LESEQGTFAVREAAPPTFYR Q6W5G7_XENLA 126 0 -
LENEQGTYGAREAAPPAFYR Q0KKA1_9AMPH 125 0 -
LDSDQGSFGAREAAPPAFYR A8VFJ8_PLEWA 125 0 -

Motif 8 width=20
Element Seqn Id St Int Rpt
NSDNRRQGGRERLASTNDKG A8KAF4_HUMAN 153 1 -
NSDNRRQGGRERLASTNDKG Q5T5H7_HUMAN 153 1 -
NSDNRRQGGRERLASTNDKG Q14268 153 1 -
NSDNRRQGGRERLASTNDKG Q14267 153 1 -
NSDNRRQGGRERLASTNDKG ESTR_HUMAN 153 1 -
NSDNRRQGGRERLASTNDKG B6ZGU3_HUMAN 153 1 -
NSDNRRQGGRERLASTNDKG B6CK22_TRAOB 153 1 -
NSDNRRQGGRERLASTNDKG B6CK20_CERAE 153 1 -
NSDNRRQGGRERLASTNDKG B6CK18_HYLLA 153 1 -
NSDNRRQGGRERLASTNDKG B6CK17_PONPY 153 1 -
NSDNRRQGGRERLASTNDKG B6CK16_9PRIM 153 1 -
NSDNRRQGGRERLASTNDKG B6CK15_PANPA 153 1 -
NSDNRRQGGRERLASTNDKG B6CK21_COLGU 153 1 -
NSDNRRQGGRERLASTNDKG B6CK19_PAPAN 153 1 -
NSDNRRQGGRERLASTSDKG A2TEV4_PIG 153 1 -
NSDNRRQGGRERLASTSDKG ESTR_PIG 153 1 -
NSDNRRQGGRERLPSTNDKG B6CK23_ATEPA 153 1 -
NSDNRRQGGRERLASTNDKG B6CK24_CEBAP 153 1 -
TSDNRRQSGRERLASTGDKG ESR1_FELCA 153 1 -
NSDNRRQGGRERLASTSDKG ESR1_BOVIN 154 1 -
NSDNRRQNGRERLSSSNEKG B3VQI7_MOUSE 154 1 -
NSDNRRQNGRERLSSSNEKG Q3UT58_MOUSE 157 1 -
NSDNRRQNGRERLSSSNEKG ESTR_MOUSE 157 1 -
NSDNRRQSGRERLSSSSEKG ESR1_MESAU 153 1 -
NSDNRRQNGRERLSSSSEKG D0FYH4_RAT 158 1 -
NSDNRRQNGRERLSSSSEKG ESTR_RAT 158 1 -
NADNRRQGGRERLASSGDKG ESR1_HORSE 153 1 -
SSDNRRQGSRERMSSTSEKG A8QZK3_9SAUR 147 1 -
SSDNRRQGSRERMSSTSEKG B6E1V9_9SAUR 147 1 -
SSDNRRHSIRERMSSTNEKG ESTR_CHICK 147 1 -
SSDNRRHSIRERMSSTNDKG B6ZK18_9FALC 145 1 -
SSDNRRHSIRERMSSTNDKG B6ZK19_TORTR 145 1 -
NSDNRRQSGRERLSNNGEKG Q1EDB6_MICOH 157 1 -
SSDNRRHSIRERMSSASEKG Q8AYH0_COTJA 147 1 -
SSDNRRQGSRERMSSTSEKG B6CZ21_9SAUR 147 1 -
GADNRRQSGRERMSSTSEKA Q3LGB2_CRONI 147 1 -
NSDNRRHSIRERMSSANEKG Q91250 145 1 -
GADSRRQSGRERMSSTSEKT Q765N7_ALLMI 147 1 -
SSDNRRQSGRERMSSANDKG B2NIY0_XENLA 147 1 -
SSDNRRQSGRERMSSANDKG B2NIY1_XENLA 147 1 -
SADSRHQSGRERMSSTSEKA Q8UWB0_CAICR 147 1 -
SSDNRRQSGRERMTSANDKG Q25C14_XENTR 147 1 -
SSDNRRQSGRERMSSANDKG P81559 148 1 -
SSDNRRQSGRERMSSANDKG Q6W5G7_XENLA 147 1 -
SSDLRRQTGRERISTASEKG Q0KKA1_9AMPH 146 1 -
SSDLRRQPGRERPSTASEKG A8VFJ8_PLEWA 146 1 -