SPRINT Home UMBER Home Contents Standard Search Advanced Search Relation Search

==SPRINT==> PRINTS View



  selected as


PR00420

Identifier
RNGMNOXGNASE  [View Relations]  [View Alignment]  
Accession
PR00420
No. of Motifs
6
Creation Date
16-AUG-1995  (UPDATE 29-JUN-1999)
Title
Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature
Database References

INTERPRO; IPR000733
UMBBD; e0084; e0148; e0195; e0152; e0149; e0208

PDB; 1PBF
SCOP; 1PBF
Literature References
1. HARAYAMA, S., KOK, M. AND NEIDLE, E.L. 
Functional and evolutionary relationships among diverse oxygenases.
ANNU.REV.MICROBIOL. 46 565-601 (1992).
 
2. SCHREUDER, H.A., MATTEVI, A., OBMOLOVA, G., KALK, K.H., HOL, W.G.,
VAN DER BOLT, F.J. AND VAN BERKEL, W.J. 
Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed 
with 4-aminobenzoate, 2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate 
and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate.
Evidence for a proton channel and a new binding mode of the flavin ring.
BIOCHEMISTRY 33 10161-10170 (1994).
 
3. WIERENGA, R.K., TERPSTRA, P. AND HOL, W.G.
Prediction of the occurrence of the ADP-binding beta-alpha-beta-fold 
in proteins, using an amino acid sequence fingerprint.
J.MOL.BIOL. 187 101-107 (1986).

Documentation
Dioxygen can be incorporated directly into organic compounds in reactions 
catalysed by enzymes termed oxygenases or hydroxylases: oxygenases that
catalyse the incorporation of both atoms of dioxygen into substrates are
known as dioxygenases; those that catalyse the incorporation of only one
atom of dioxygen are termed monooxygenases, or mixed-function oxygenases.
The second atom of dioxygen is reduced to H2O either by the substrates
themselves or by a co-substrate reductant [1].
 
One of the first steps in aerobic degradation of aromatic compounds
involves introduction of one or two hydroxyl groups onto the aromatic ring.
Incorporation of single hydroxyl groups (monohydroxylation) is generally
catalysed by monooxygenases. In bacteria, the majority of monooxygenases
catalysing monohydroxylation of aromatic rings of substituted phenols are
single-component flavoenzymes, although multi-component monooxygenases,
such as phenol and toluene-4 monooxygenase, have also been found.
 
The structure and reaction mechanism of a bacterial single-component
aromatic-ring hydroxylase, para-hydroxybenzoate hydroxylase (PHBH), have
been characterised [2]. Monooxygenases of this class can be divided into
several subgroups. Local sequence similarities between the group of PHBH
and salicylate hydroxylase and that of dichlorophenol and phenol
hydroxylases are confined to 2 regions [1]. In the first of these, at the
N-terminus, a conserved ADP-binding motif is found associated with a beta-
alpha-beta fold [3]: in PHBH, this region binds the ADP portion of FAD; in
dichlorophenol and phenol hydroxylases, however, it may be involved in
binding NADPH rather than FAD, since highly-conserved Asp or Glu residues
associated with NADH or FAD binding are absent. The second region of
similarity (residues 276-329 in PHBH), may be involved in FAD binding as,
in the 3D structure of PHBH, this region contains an FAD-binding beta-
strand. With the exception of these 2 regions, the sequences of
flavoprotein monooxygenases vary significantly.
 
RNGMNOXGNASE is a 6-element fingerprint that provides a signature for the
bacterial aromatic-ring hydroxylases (flavoprotein monooxygenases). The 
fingerprint was derived from an initial alignment of 14 sequences: motif 1
corresponds to the ADP binding site; motifs 3-6 were drawn from the region
associated with flavin binding in PHBH (residues 278-344). Two iterations 
on OWL26.0 were required to reach convergence, at which point a true set 
comprising 19 sequences was identified. Several partial matches were also 
found: VISC_ECOLI, YBJ8_YEAST and A55767 match the first 4 motifs; 
BCH3_RHOCA matches the first 3 motifs; UBIH_ECOLI matches motifs 1, 2 and 4;
and most of the sequences matching only 2 motifs (one of which is motif 1)
are FAD-containing oxidoreductases.
 
An update on SPTR37_9f identified a true set of 30 sequences, and 49
partial matches.
Summary Information
  30 codes involving  6 elements
9 codes involving 5 elements
4 codes involving 4 elements
18 codes involving 3 elements
18 codes involving 2 elements
Composite Feature Index
6303030303030
5489978
4444310
3218181600
201616400
123456
True Positives
HYDL_STRHA    MHPA_ECOLI    O05144        O06647        
O07561 O30873 O68977 O69353
O86481 P71029 P72497 P94134
P95598 P96555 PCPB_FLAS3 PH2M_TRICU
PHEA_PSESP PHHY_PSEAE PHHY_PSEFL Q06519
Q51986 Q52159 Q53552 Q53961
Q54171 Q54530 Q56156 Q59724
TCMG_STRGA TFDB_ALCEU
True Positive Partials
Codes involving 5 elements
NAHG_PSEPU O34025 O48701 P72495
PHHY_ACICA Q53657 Q59700 Q59744
TBUD_BURPI
Codes involving 4 elements
O50491 O81816 O86484 TETX_BACFR
Codes involving 3 elements
CHLP_SYNY3 COQ6_CAEEL COQ6_YEAST O06489
O24844 O30447 O66509 O81360
O81815 O88867 Q01446 Q27577
Q51376 Q92402 VISC_ECOLI YBJ8_YEAST
YD00_SYNY3 YLEB_ECOLI
Codes involving 2 elements
BCHP_RHOCA O06538 O08453 O15229
O31265 O53772 O54177 O57920
O58094 O65936 O81335 P93236
Q21794 Q21795 Q40412 Q96375
UBIH_ECOLI Y08M_MYCTU
Sequence Titles
HYDL_STRHA  PUTATIVE POLYKETIDE HYDROXYLASE (EC 1.14.13.-) - STREPTOMYCES HALSTEDII. 
MHPA_ECOLI 3-(3-HYDROXY-PHENYL)PROPIONATE HYDROXYLASE (EC 1.14.13.-) - ESCHERICHIA COLI.
O05144 3-(3-HYDROXYPHENYL) PROPIONATE HYDROXYLASE - RHODOCOCCUS GLOBERULUS.
O06647 2-HYDROXYBIPHENYL-3-MONOOXYGENASE - PSEUDOMONAS AZELAICA.
O07561 HYPOTHETICAL 54.4 KD PROTEIN - BACILLUS SUBTILIS.
O30873 P-HYDROXYBENZOATE HYDROXYLASE (EC 1.14.13.2) (4-HYDROXYBENZOATE 3-MONOOXYGENASE) - AZOTOBACTER CHROOCOCCUM MCD 1.
O68977 PENTACHLOROPHENOL 4-MONOOXYGENASE - SPHINGOMONAS SP. UG30.
O69353 HYDROXYLASE - RHODOCOCCUS ERYTHROPOLIS.
O86481 OXYGENASE - STREPTOMYCES ARGILLACEUS.
P71029 4-METHYL-5-NITROCATECHOL OXYGENASE - BURKHOLDERIA SP.
P72497 AKLAVINONE C-11 HYDROXYLASE - STREPTOMYCES PEUCETIUS.
P94134 CHLOROPHENOL MONOOXYGENASE - ALCALIGENES EUTROPHUS.
P95598 RIFAMPIN MONOOXYGENASE - CORYNEBACTERIUM EQUII (RHODOCOCCUS EQUI).
P96555 SALICYLATE HYDROXYLASE - SPHINGOMONAS SP.
PCPB_FLAS3 PENTACHLOROPHENOL 4-MONOOXYGENASE (EC 1.14.13.50) (PENTACHLOROPHENOL HYDROXYLASE) - FLAVOBACTERIUM SP. (STRAIN ATCC 39723).
PH2M_TRICU PHENOL 2-MONOOXYGENASE (EC 1.14.13.7) (PHENOL HYDROXYLASE) - TRICHOSPORON CUTANEUM.
PHEA_PSESP PHENOL 2-MONOOXYGENASE (EC 1.14.13.7) (PHENOL HYDROXYLASE) - PSEUDOMONAS SP. (STRAIN EST1001).
PHHY_PSEAE P-HYDROXYBENZOATE HYDROXYLASE (EC 1.14.13.2) (4-HYDROXYBENZOATE 3- MONOOXYGENASE) (PHBH) - PSEUDOMONAS AERUGINOSA.
PHHY_PSEFL P-HYDROXYBENZOATE HYDROXYLASE (EC 1.14.13.2) (4-HYDROXYBENZOATE 3- MONOOXYGENASE) - PSEUDOMONAS FLUORESCENS.
Q06519 P-HYDROXYBENZOATE HYDROXYLASE (EC 1.14.13.2) (4-HYDROXYBENZOATE 3-MONOOXYGENASE) - PSEUDOMONAS FLUORESCENS.
Q51986 2,4-DICHLOROPHENOL HYDROXYLASE - PSEUDOMONAS PUTIDA.
Q52159 PHENOL MONOOXYGENASE - PSEUDOMONAS SP.
Q53552 SALICYLATE HYDROXYLASE - PSEUDOMONAS PUTIDA.
Q53961 PCPB - SPHINGOMONAS CHLOROPHENOLICA.
Q54171 PUTATIVE OXYGENASE - STREPTOMYCES FRADIAE.
Q54530 RDME - STREPTOMYCES PURPURASCENS.
Q56156 C-16 HYDROXYLASE - STREPTOMYCES VIOLACEUS (STREPTOMYCES VENEZUELAE).
Q59724 4-HYDROXYBENZOATE 3-MONOOXYGENASE (EC 1.14.13.2) (P-HYDROXYBENZOATE HYDROXYLASE) - PSEUDOMONAS SP.
TCMG_STRGA TETRACENOMYCIN POLYKETIDE SYNTHESIS HYDROXYLASE TCMG (EC 1.14.13.-) - STREPTOMYCES GLAUCESCENS.
TFDB_ALCEU 2,4-DICHLOROPHENOL 6-MONOOXYGENASE (EC 1.14.13.20) (2,4-DICHLOROPHENOL HYDROXYLASE) (2,4-DCP HYDROXYLASE) - ALCALIGENES EUTROPHUS.

NAHG_PSEPU SALICYLATE HYDROXYLASE (EC 1.14.13.1) (SALICYLATE 1-MONOOXYGENASE) - PSEUDOMONAS PUTIDA.
O34025 2,4-DICHLOROPHENOL HYDROXYLASE - BURKHOLDERIA CEPACIA (PSEUDOMONAS CEPACIA).
O48701 F3I6.28 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P72495 AKLAVINONE C-11 HYDROXYLASE - STREPTOMYCES PEUCETIUS.
PHHY_ACICA P-HYDROXYBENZOATE HYDROXYLASE (EC 1.14.13.2) (4-HYDROXYBENZOATE 3- MONOOXYGENASE) - ACINETOBACTER CALCOACETICUS.
Q53657 6-HYDROXYLATION ENZYME OF TETRACYCLINE - STREPTOMYCES AUREOFACIENS.
Q59700 SALICYLATE 1-MONOOXYGENASE (EC 1.14.13.1) (SALICYLATE HYDROXYLASE) - PSEUDOMONAS PUTIDA.
Q59744 4-HYDROXYBENZOATE HYDROXYLASE (EC 1.14.13.2) (4-HYDROXYBENZOATE 3-MONOOXYGENASE) (P-HYDROXYBENZOATE HYDROXYLASE) - RHIZOBIUM LEGUMINOSARUM.
TBUD_BURPI PHENOL 2-MONOOXYGENASE (EC 1.14.13.7) (PHENOL HYDROXYLASE) - BURKHOLDERIA PICKETTII (PSEUDOMONAS PICKETTII).

O50491 POSSIBLE MONOOXYGENASE - STREPTOMYCES COELICOLOR.
O81816 MONOOXYGENASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O86484 OXYGENASE - STREPTOMYCES ARGILLACEUS.
TETX_BACFR TETRACYCLINE RESISTANCE PROTEIN (TRANSPOSON TN4351/TN4400) - BACTEROIDES FRAGILIS.

CHLP_SYNY3 GERANYLGERANYL HYDROGENASE - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
COQ6_CAEEL PUTATIVE UBIQUINONE BIOSYNTHESIS MONOOXGENASE COQ6 (EC 1.14.13.-) - CAENORHABDITIS ELEGANS.
COQ6_YEAST UBIQUINONE BIOSYNTHESIS MONOOXGENASE COQ6 (EC 1.14.13.-) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
O06489 YFNL - BACILLUS SUBTILIS.
O24844 HYPOTHETICAL 42.4 KD PROTEIN - ACINETOBACTER SP. ADP1.
O30447 HYPOTHETICAL 45.1 KD PROTEIN - BORDETELLA PERTUSSIS.
O66509 HYPOTHETICAL 42.2 KD PROTEIN - AQUIFEX AEOLICUS.
O81360 ZEAXANTHIN EPOXIDASE PRECURSOR (EC 1.14.-.-) (ZEAEPOX) - PRUNUS ARMENIACA (APRICOT).
O81815 MONOOXYGENASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O88867 KYNURENINE 3-HYDROXYLASE - RATTUS NORVEGICUS (RAT).
Q01446 MAACKIAIN DETOXIFICATION (MAK1) - NECTRIA HAEMATOCOCCA.
Q27577 KYNURENINE 3-MONOOXYGENASE (EC 1.14.13.9) (KYNURENINE 3-HYDROXYLASE) - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q51376 FAD BINDING PROTEIN HOMOLOG - PSEUDOMONAS AERUGINOSA.
Q92402 4-AMINOBENZOATE HYDROXYLASE (EC 1.14.13.27) - AGARICUS BISPORUS (COMMON MUSHROOM).
VISC_ECOLI VISC PROTEIN (EC 1.-.-.-) - ESCHERICHIA COLI.
YBJ8_YEAST HYPOTHETICAL 52.4 KD PROTEIN IN ATP1-ROX3 INTERGENIC REGION PRECURSOR - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
YD00_SYNY3 HYPOTHETICAL 45.6 KD PROTEIN SLR1300 - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
YLEB_ECOLI HYPOTHETICAL 43.0 KD PROTEIN IN CUTE-GLNX INTERGENIC REGION - ESCHERICHIA COLI.

BCHP_RHOCA GERANYLGERANYL HYDROGENASE - RHODOBACTER CAPSULATUS (RHODOPSEUDOMONAS CAPSULATA).
O06538 HYPOTHETICAL 36.3 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O08453 2-METHYL-3-HYDROXYPYRIDINE-5-CARBOXYLIC ACID OXYGENASE (EC 1.14.12.4) (3-HYDROXY-2-METHYLPYRIDINECARBOXYLATE DIOXYGENASE) (METHYLHYDROXYPYRIDINECARBOXYLATE OXIDASE) - PSEUDOMONAS SP.
O15229 KYNURENINE 3-MONOOXYGENASE (EC 1.14.13.9) - HOMO SAPIENS (HUMAN).
O31265 HYPOTHETICAL 42.2 KD PROTEIN - ARTHROBACTER SP.
O53772 PUTATIVE OXIDOREDUCTASE - MYCOBACTERIUM TUBERCULOSIS.
O54177 PUTATIVE OXIDOREDUCTASE - STREPTOMYCES COELICOLOR.
O57920 393AA LONG HYPOTHETICAL PROTEIN - PYROCOCCUS HORIKOSHII.
O58094 370AA LONG HYPOTHETICAL PROTEIN - PYROCOCCUS HORIKOSHII.
O65936 HYPOTHETICAL 50.4 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O81335 GERANYLGERANYL HYDROGENASE - MESEMBRYANTHEMUM CRYSTALLINUM (COMMON ICE PLANT).
P93236 ZEAXANTHIN EPOXIDASE PRECURSOR (EC 1.14.-.-) - LYCOPERSICON ESCULENTUM (TOMATO).
Q21794 R07B7.4 PROTEIN - CAENORHABDITIS ELEGANS.
Q21795 R07B7.5 PROTEIN - CAENORHABDITIS ELEGANS.
Q40412 ZEAXANTHIN EPOXIDASE PRECURSOR (EC 1.14.-.-) - NICOTIANA PLUMBAGINIFOLIA (LEADWORT-LEAVED TOBACCO).
Q96375 ZEAXANTHIN EPOXIDASE PRECURSOR (XANTHOPHYLL EPOXIDASE) (BETA- CYCLOHEXENYL EPOXIDASE) - CAPSICUM ANNUUM (BELL PEPPER).
UBIH_ECOLI UBIH PROTEIN (EC 1.14.13.-) - ESCHERICHIA COLI.
Y08M_MYCTU HYPOTHETICAL 41.3 KD PROTEIN CY50.22C - MYCOBACTERIUM TUBERCULOSIS.
Scan History
OWL25_3    2  750  NSINGLE    
SPTR37_9f 2 100 NSINGLE
Initial Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
QVAIIGAGPSGLLLGQLLHKAGI PHHY_PSEAE 4 4 -
QVAIIGAGPSGLLLGQLLHKAGI PHHY_PSEFL 4 4 -
DVLIVGAGPAGLMAARVLSEYVR PH2M_TRICU 9 9 -
PVLVVGGSLVGLSTSVFLGRLGV HYDL_STRHA 16 16 -
DVLVVGTGPAGASAGALLARYGV TFDB_ALCEU 8 8 -
EVLIVGSGPAGSSAAMFLSTQGI PHEA_PSESP 37 37 -
PVLIVGGGLTGLSAALFLSQHGV TCMG_STRGA 18 18 -
RIGIVGGGISGVALALELCRYSH NAHG_PSEPU 8 8 -
AVLIVGGGPTGLIAANELLRRGV A40640 16 16 -
DVLIVGAGPAGVMAAAHLLSYGT TBUD_PSEPI 9 9 -
KVAIIGSGPAGLLLGQLLYKAGI PHHY_ACICA 7 7 -
QVGIIGAGPAGLLLSHLLCIAGI S37051 8 8 -
DVLVVGAGLGGLSTAMFLARQGV SPU104053 7 7 -
NVAIIGGGPVGLTMAKLLQQNGI TETX_BACFR 18 18 -

Motif 2 width=16
Element Seqn Id St Int Rpt
MKDVDENFPGELSTSG TBUD_PSEPI 216 184 -
ECDFIAGCDGYHGVCR PHHY_ACICA 153 123 -
RCDLLIGADGIKSALR NAHG_PSEPU 153 122 -
SPRWVIGADGVRSRVR A40640 165 126 -
VCDYVVGCDGFHGPSR S37051 154 123 -
RAGYLVGADGNRSLVR SPU104053 171 141 -
TADLVILANGGMSKVR TETX_BACFR 160 119 -
RARYLIAADGVRSPVR TCMG_STRGA 189 148 -
RAKYLIGADGARSKVA PHEA_PSESP 199 139 -
RSKYLIGADGANSRVV TFDB_ALCEU 170 139 -
RADYLVAADGPRSPVR HYDL_STRHA 175 136 -
HCKYVIGCDGGHSWVR PH2M_TRICU 217 185 -
DCDYIAGCDGFHGISR PHHY_PSEFL 151 124 -
DCDYIAGCDGFHGISR PHHY_PSEAE 151 124 -

Motif 3 width=16
Element Seqn Id St Int Rpt
PLPITMIGDAAHLMPP TETX_BACFR 303 127 -
HGRLFLAGDAAHIVPP PHHY_PSEAE 278 111 -
HGRLFLAGDAAHIVPP PHHY_PSEFL 278 111 -
DERVFIAGDACHTHSP PH2M_TRICU 349 116 -
AGRVFLAGDSAHEMSP HYDL_STRHA 305 114 -
QGRVFCAGDAVHRHPP TFDB_ALCEU 303 117 -
KGRVCCAGDAIHKHPP PHEA_PSESP 321 106 -
SGRVFLAGDAAHVHPP TCMG_STRGA 325 120 -
FGKLFLAGDAAHIVPP PHHY_ACICA 280 111 -
HGRVVLIGDAAHAMLP NAHG_PSEPU 305 136 -
KGNVFLAGDAAHCHSP A40640 290 109 -
EGRVFLAGDARHRHPP TBUD_PSEPI 296 64 -
YGRLLLAGDAAHIVPP S37051 281 111 -
EGRVFLAGDAAKVTPP SPU104053 300 113 -

Motif 4 width=17
Element Seqn Id St Int Rpt
PTGAKGLNLAASDVSTL PHHY_PSEAE 293 -1 -
PAGAFGANGGIQDAHNL TCMG_STRGA 340 -1 -
PSHGLGSNTSIQDSYNL PHEA_PSESP 336 -1 -
PTNGLGSNTSIQDSFNL TFDB_ALCEU 318 -1 -
PTGAFGSNTGIQDAHNL HYDL_STRHA 320 -1 -
PKAGQGMNTSMMDTYNL PH2M_TRICU 364 -1 -
PTGAKGLNLAASDVSTL PHHY_PSEFL 293 -1 -
PTGAKGLNLAASDIAYL PHHY_ACICA 295 -1 -
PHQGAGAGQGLEDAYFL NAHG_PSEPU 320 -1 -
PSGGSGMNVGMQDAFNL A40640 305 -1 -
PLTGIGKNTSIADCYNL TBUD_PSEPI 311 -1 -
PTGAKGLNLAVNDVRLL S37051 296 -1 -
PTGGMSGNAAVADGFDL SPU104053 315 -1 -
PFAGQGVNSGLVDALIL TETX_BACFR 318 -1 -

Motif 5 width=19
Element Seqn Id St Int Rpt
WKLAAVLKGTAGDALLDTY TCMG_STRGA 358 1 -
SDNLADGKFNSIEEAVKNY TETX_BACFR 335 0 -
WKLAAVLQGQAGAGLLDTY SPU104053 333 1 -
AKAFAELYTTGSQERLLSY S37051 313 0 -
WKLLGVLLGVARADPARTY TBUD_PSEPI 329 1 -
WKIAMVERGEAKPDLLDTY A40640 323 1 -
LLGDTQADAGNLAELLEAY NAHG_PSEPU 339 2 -
WKLACVLKGQAGPELLETY PHEA_PSESP 354 1 -
WKIAMVLNGTADESLLDTY TFDB_ALCEU 336 1 -
WKLAAVLGGWAGDGLLDTY HYDL_STRHA 338 1 -
WKLGLVLTGRAKRDILKTY PH2M_TRICU 382 1 -
YRLLLKAYREGRGELLERY PHHY_PSEFL 310 0 -
YRLLLKAYREGRGELLERY PHHY_PSEAE 310 0 -
SSALIEFYTQGSEQGIDQY PHHY_ACICA 312 0 -

Motif 6 width=17
Element Seqn Id St Int Rpt
YSAICLRRIWKAERFSW PHHY_PSEAE 328 -1 -
YEQQMFMYGKEAQEEST TETX_BACFR 353 -1 -
YEDERKVAAELVVAEAL SPU104053 351 -1 -
YSHDALRRVWRAEQFSW S37051 331 -1 -
YVAERVYIRMRAATDIA TBUD_PSEPI 347 -1 -
YHTERTPVAQQLLEGTH A40640 341 -1 -
YDDLRRPRACRVQQTSW NAHG_PSEPU 357 -1 -
YEQERLPIGAAVADQAW TCMG_STRGA 376 -1 -
YSTERAPIAKQIVTRAN PHEA_PSESP 372 -1 -
YTIERAPIAKQVVCRAN TFDB_ALCEU 354 -1 -
YDAERRPVAEATTARAA HYDL_STRHA 356 -1 -
YEEERHAFAQALIDFDH PH2M_TRICU 400 -1 -
YSAICLRRIWKAERFSW PHHY_PSEFL 328 -1 -
YSEKCLQRVWKAERFSW PHHY_ACICA 330 -1 -
Final Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
PVLIVGGGLTGLSAALFLSQHGV TCMG_STRGA 18 18 -
DVIIVGAGPTGLMLAGELRLQGV P95598 3 3 -
EVLIVGSGPAGSSAAMFLSTQGI PHEA_PSESP 37 37 -
EVLIVGSGPAGSSAAMFLSTQGI Q52159 37 37 -
DVLIVGAGPAGAMSATLLASLGI O06647 8 8 -
DVLVVGSGPAGAASTLLLATYGV Q51986 11 11 -
DVLVVGTGPAGAASTLLLATYGV P94134 11 11 -
DVLVVGTGPAGASAGALLARYGV TFDB_ALCEU 8 8 -
AVLIVGGGPTGLIAANELLRRGV PCPB_FLAS3 15 15 -
AVLIVGGGPTGLIAANELLRRGV O68977 16 16 -
PVLVVGGSLVGLSTSVFLGRLGV HYDL_STRHA 16 16 -
AVLIVGGGPTGLIAANELLRLRV Q53961 16 16 -
PVLIVGGSMVGLSTALFLSHYGI P71029 14 14 -
DVLVVGAGLGGLSTAMFLARQGV Q54530 7 7 -
SVIVAGAGPTGLMLAGELRLAGV Q54171 4 4 -
RVLVAGAGPVGLTAAHELARRGL O86481 6 6 -
EAVIIGGGPVGFMLASELAIAGV O07561 6 6 -
DVVVIGAGPTGLMLAGELRLGGA Q56156 27 27 -
PVLIVGGGGCGLTTSILLSEHGI O69353 7 7 -
DVLVVGGGLGGLSTALFLARRGA P72497 9 9 -
EVLIVGAGPAGLMLANILGMYGK O05144 8 8 -
DVLIVGAGPAGLMAARVLSEYVR PH2M_TRICU 9 9 -
QVAIAGAGPVGLMMANYLGQMGI MHPA_ECOLI 17 17 -
QVAIIGAGPSGLLLGQLLHKAGI PHHY_PSEFL 4 4 -
QVAIIGAGPSGLLLGQLLHKAGI PHHY_PSEAE 4 4 -
QVAIIGAGPAGLLLGQLLHKAGI O30873 4 4 -
QVAIIGAGPSGLLLGQLLHNAGI Q06519 7 7 -
QVGIIGAGPAGLLLSHLLCIAGI Q59724 8 8 -
NIAIIGAGIGGLALALALRERGI P96555 2 2 -
RVAIVGGGISGLALALSLCKHSH Q53552 12 12 -

Motif 2 width=16
Element Seqn Id St Int Rpt
RARYLIAADGVRSPVR TCMG_STRGA 189 148 -
HARYLVGCDGGRSTVR P95598 143 117 -
RAKYLIGADGARSKVA PHEA_PSESP 199 139 -
RAKYLIGADGARSKVA Q52159 199 139 -
RAKYIIGADGAHSLVA O06647 170 139 -
RAKYLIGADGANSQVV Q51986 173 139 -
RAKYLIGADGANSRIV P94134 173 139 -
RSKYLIGADGANSRVV TFDB_ALCEU 170 139 -
SPRWVIGADGVRSRVR PCPB_FLAS3 164 126 -
APRWVIGADGVRSRVR O68977 165 126 -
RADYLVAADGPRSPVR HYDL_STRHA 175 136 -
NPRWVIGADGVRSRVR Q53961 165 126 -
RSRYLVASDGWRSQRR P71029 172 135 -
RAGYLVGADGNRSLVR Q54530 171 141 -
TAPYLVGCDGGRSTVR Q54171 145 118 -
RVPWLVGCDGGHSTVR O86481 155 126 -
TSKFAVGADGAGSTVR O07561 150 121 -
RARYAVGCDGERTTVR Q56156 168 118 -
HAQYVVAADGGKTVGP O69353 175 145 -
SARYLVAADGPRSAIR P72497 171 139 -
SAQYLVGCEGGKSPTR O05144 161 130 -
HCKYVIGCDGGHSWVR PH2M_TRICU 217 185 -
KAQWLVACDGGASFVR MHPA_ECOLI 166 126 -
DCDYIAGCDGFHGISR PHHY_PSEFL 151 124 -
DCDYIAGCDGFHGISR PHHY_PSEAE 151 124 -
DCDYIAGCDGFHGVSR O30873 151 124 -
ECDYIAGCDGFHGVAR Q06519 154 124 -
VCDYVVGCDGFHGPSR Q59724 154 123 -
IADVVIGADGVRSVIR P96555 149 124 -
RCDLLIGRDGIKSALR Q53552 156 121 -

Motif 3 width=16
Element Seqn Id St Int Rpt
SGRVFLAGDAAHVHPP TCMG_STRGA 325 120 -
RDRVFLAGDAAHIHPP P95598 270 111 -
KGRVCCAGDAIHKHPP PHEA_PSESP 321 106 -
KGRVCCAGDAIHKHPP Q52159 321 106 -
SGRVFCMGDAVHRHTP O06647 305 119 -
DNRVFCMGDAVHRHPP Q51986 306 117 -
DKRVFCMGDAVHRHPP P94134 306 117 -
QGRVFCAGDAVHRHPP TFDB_ALCEU 303 117 -
KGNVFLAGDAAHCHSP PCPB_FLAS3 289 109 -
KGGVFLAGDAAHCHSP O68977 290 109 -
AGRVFLAGDSAHEMSP HYDL_STRHA 305 114 -
KGNVFLAGDAAHCHSP Q53961 290 109 -
GGRIFLRGDAAHVVPP P71029 306 118 -
EGRVFLAGDAAKVTPP Q54530 300 113 -
RGRVLLAGDAAHIHLP Q54171 269 108 -
EGRVFVAGDAAHVHSP O86481 277 106 -
DGRIFLAGDAAHIHFP O07561 274 108 -
DGRVLWAGDAAHQQMP Q56156 289 105 -
VGRIFLAGDAAHRHPP O69353 309 118 -
EGPVLLVGDAAKVTPP P72497 300 113 -
KGRQLIAGDAAHLMPV O05144 282 105 -
DERVFIAGDACHTHSP PH2M_TRICU 349 116 -
IDRVLLAGDAAHIMPV MHPA_ECOLI 287 105 -
HGRLFLAGDAAHIVPP PHHY_PSEFL 278 111 -
HGRLFLAGDAAHIVPP PHHY_PSEAE 278 111 -
YGRLFLVGDAAHIVPP O30873 278 111 -
YGRLFLLGDAAHIVPP Q06519 281 111 -
YGRLLLAGDAAHIVPP Q59724 281 111 -
KGPAVLIGDAAHAMLP P96555 285 120 -
HGRVALIGDAAHAMLP Q53552 307 135 -

Motif 4 width=17
Element Seqn Id St Int Rpt
PAGAFGANGGIQDAHNL TCMG_STRGA 340 -1 -
PMGGQGLNLGVQDAFNL P95598 285 -1 -
PSHGLGSNTSIQDSYNL PHEA_PSESP 336 -1 -
PSHGLGSNTSIQDSYNL Q52159 336 -1 -
PMGGLGLNTSVQDAYNL O06647 320 -1 -
PTNGLGSNTSIQDAFNL Q51986 321 -1 -
PTNGLGSNTSIQDAFNL P94134 321 -1 -
PTNGLGSNTSIQDSFNL TFDB_ALCEU 318 -1 -
PSGGSGMNVGMQDAFNL PCPB_FLAS3 304 -1 -
PSGGSGMNVGMQDAFNL O68977 305 -1 -
PTGAFGSNTGIQDAHNL HYDL_STRHA 320 -1 -
PSGGSGMNVGMQDAFNL Q53961 305 -1 -
PYGGFGGNTGVQDAHNL P71029 321 -1 -
PTGGMSGNAAVADGFDL Q54530 315 -1 -
PAGGQGMNTGIQDAVNL Q54171 284 -1 -
PASGRGMNTGVQEAYNL O86481 292 -1 -
PAGGQGLNVGLQDAMNL O07561 289 -1 -
PIGGQALNLGLQDAVNL Q56156 304 -1 -
PTTGLGLNTAIQDAHNL O69353 324 -1 -
PTGGMGGNTAIGDGFDV P72497 315 -1 -
VWMGQGWNSGMRDATNL O05144 297 -1 -
PKAGQGMNTSMMDTYNL PH2M_TRICU 364 -1 -
VWQGQGYNSGMRDAFNL MHPA_ECOLI 302 -1 -
PTGAKGLNLAASDVSTL PHHY_PSEFL 293 -1 -
PTGAKGLNLAASDVSTL PHHY_PSEAE 293 -1 -
PTGAKGLNLAGSDVCYL O30873 293 -1 -
PTGAKGLNLAASDVSTL Q06519 296 -1 -
PTGAKGLNLAVNDVRLL Q59724 296 -1 -
PHHGQGANTSIEDACVL P96555 300 -1 -
PHQGAGAGQGLEDAYFL Q53552 322 -1 -

Motif 5 width=19
Element Seqn Id St Int Rpt
WKLAAVLKGTAGDALLDTY TCMG_STRGA 358 1 -
WKLAAEINGWAPVGLLDTY P95598 303 1 -
WKLACVLKGQAGPELLETY PHEA_PSESP 354 1 -
WKLACVLKGQAGPELLETY Q52159 354 1 -
WKLALVLKGTAAPTLLDSY O06647 338 1 -
WKLSHVLQGKAGPELLATY Q51986 339 1 -
WKLSHVLRGKAGPELLATY P94134 339 1 -
WKIAMVLNGTADESLLDTY TFDB_ALCEU 336 1 -
WKIAMVERGEAKPDLLDTY PCPB_FLAS3 322 1 -
WKIALVERGEARPELLDSY O68977 323 1 -
WKLAAVLGGWAGDGLLDTY HYDL_STRHA 338 1 -
WKIAMVERGEQKPDLLDTY Q53961 323 1 -
SKLALVLDGTAGEALLDTY P71029 339 1 -
WKLAAVLQGQAGAGLLDTY Q54530 333 1 -
WKLAAVLRGTASESLLDSY Q54171 302 1 -
WKLALVAEGHAERELLDSY O86481 310 1 -
WKLAAAIKGSAPSWLLDSY O07561 307 1 -
WKLAAVVRGTAPDGLLDTY Q56156 322 1 -
WKLASVINGDADAALLDTY O69353 342 1 -
WKLAAVLRGEAGERLLDSY P72497 333 1 -
WKLAAVLSGQADDALLDTY O05144 315 1 -
WKLGLVLTGRAKRDILKTY PH2M_TRICU 382 1 -
WKLALVIQGKARDALLDTY MHPA_ECOLI 320 1 -
YRLLLKAYREGRGELLERY PHHY_PSEFL 310 0 -
YRLLLKAYREGRGELLERY PHHY_PSEAE 310 0 -
FRILVKVYGEGRTDLLEKY O30873 310 0 -
FRILLKVYREGRVDLLEQY Q06519 313 0 -
AKAFAELYTTGSQERLLSY Q59724 313 0 -
ASLLAGMNTGNRDERLVQY P96555 317 0 -
LLGDSRTETGNLPELLGAY Q53552 341 2 -

Motif 6 width=17
Element Seqn Id St Int Rpt
YEQERLPIGAAVADQAW TCMG_STRGA 376 -1 -
YESERRPVAADVLDNTR P95598 321 -1 -
YSTERAPIAKQIVTRAN PHEA_PSESP 372 -1 -
YSTERAPIAKQIVTRAN Q52159 372 -1 -
YDAERSPVAKQIVERAF O06647 356 -1 -
YNEERAPVARQVVQRAN Q51986 357 -1 -
YDEERAPVARQVVQRAN P94134 357 -1 -
YTIERAPIAKQVVCRAN TFDB_ALCEU 354 -1 -
YHTERTPVAQQLLEGTH PCPB_FLAS3 340 -1 -
YQSERTPVAQQLLEGTH O68977 341 -1 -
YDAERRPVAEATTARAA HYDL_STRHA 356 -1 -
YHTERTPVAQQLLEGTL Q53961 341 -1 -
YEAERRPVGALTVDQAF P71029 357 -1 -
YEDERKVAAELVVAEAL Q54530 351 -1 -
YHSERHAVGERLMMNTK Q54171 320 -1 -
YSLERVPIGERLLGSTK O86481 328 -1 -
YHDERHPAAEGLLRNTE O07561 325 -1 -
YHDERHAVGRQVLGNIR Q56156 340 -1 -
YEPERRLVGMRNVDWAM O69353 360 -1 -
YGAERSLVSRLVVDESL P72497 351 -1 -
YTSERKDHAQAMVDLSL O05144 333 -1 -
YEEERHAFAQALIDFDH PH2M_TRICU 400 -1 -
YQQERRDHAKAMIDLSV MHPA_ECOLI 338 -1 -
YSAICLRRIWKAERFSW PHHY_PSEFL 328 -1 -
YSAICLRRIWKAERFSW PHHY_PSEAE 328 -1 -
YSELALRRVWKGERFSW O30873 328 -1 -
YSAICLRRVWKAERFSW Q06519 331 -1 -
YSHDALRRVWRAEQFSW Q59724 331 -1 -
YEALRRPRTRKIQRSAW P96555 335 -1 -
YDDLRRPHACRVQRTTV Q53552 359 -1 -