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PR00418

Identifier
TPI2FAMILY  [View Relations]  [View Alignment]  
Accession
PR00418
No. of Motifs
9
Creation Date
05-DEC-1995  (UPDATE 29-JUL-1999)
Title
DNA topoisomerase II family signature
Database References
PRINTS; PR01159 DNAGYRASEB; PR01098 TOPISMRASE4B; PR01158 TOPISMRASEII

PROSITE; PS00177 TOPOISOMERASE_II
PFAM; PF00204 DNA_topoisoII
INTERPRO; IPR001241
Literature References
1. TSAI-PFLUGFELDER, M., LIU, L.F., LIU, A.A., TEWEY, K.M., WHANG-PENG, J.,
KNUTSEN, T., HUEBNER, K., CRUCE, C.M. AND WANG, J.C.
Cloning and sequencing of cDNA encoding human DNA topoisomerase II and 
localization of the gene to chromosome region 17q21-22.
PROC.NATL.ACAD.SCI.U.S.A. 85 7177-7181 (1988).
 
2. HINDS, M., DEISSEROTH, K., MAYES, J., ALTSCHULER, E., JANSEN, R., 
LEDLEY, F.D. AND ZWELLING, L.A.
Identification of a point mutation in the topoisomerase II gene from a 
human leukemia cell line containing an amscarine-resistant form of
topoisomerase II.
CANCER RES. 51 4729-4731 (1991).
 
3. WIGLEY, D.B., DAVIES, G.J., DODSON, E.J., MAXWELL, A. AND DODSON, G.
Crystal structure of an N-terminal fragment of the DNA gyrase B protein.
NATURE 351 624-629 (1991).

Documentation
Topoisomerases catalyse the interconversion of topological isomers of DNA
and play a key role in DNA metabolism [1]. Topoisomerase I catalyses an ATP-
independent reaction, while topoisomerase II catalyses an ATP-dependent
reaction, resulting in the formation of DNA supercoils [1-3]. The supercoil
is formed by transient cleavage in both strands of double-stranded DNA,
followed by the passage of a segment of DNA through the break, and break
ligation [3]. Eukaryotic enzymes can form both positive and negative
supercoils, while prokaryotic enzymes form only negative supercoils.
 
Eukaryotic topoisomerase II exists as a homodimer; in bacteriophage T4 it 
consists of 3 heterologous subunits; in prokaryotes it exists as a tetramer
of 2 subunits (2 each of gyrA and gyrB); and in E.coli, a second type II
topoisomerase, involved in chromosome segregation (topoisomerase IV),
consists of 2 subunits (parC and parE). GyrB, parE, and the product of 
bacteriophage T4 gene 39, are all similar to the eukaryotic proteins [1-3].
 
Structural studies of E.coli topoisomerase II have shown that the enzyme
binds to DNA, forming a complex in which a DNA strand of approximately 120
base pairs is wound around a protein core [3]. At low resolution, this
complex resembles a flattened sphere, and may be heart-shaped, with the DNA
embedded in the protein. There is evidence for channels or cavities in
the complex, which may have a role in the DNA translocation process [3].
 
The gyrB protein possesses 2 uniquely-folded domains. The N-terminal domain
(domain 1) possesses ATP-binding and hydrolysis functions, and forms an
8-stranded anti-parallel beta-sheet with unusual strand connectivities - the
structure, which is stabilised by a hydrophobic core, can be subdivided
into 6- and 2-stranded anti-parallel sheets, connected by a parallel sheet
[3]. The C-terminal domain (domain 2) contains a 4-stranded mixed parallel
and anti-parallel beta-sheet. Four helices are also present, 2 of which are
rich in arginine residues. The gyrB dimer is punctured by a 20A hole, which
may provide a gateway through which DNA is passed during supercoiling [3].
Every arginine of domain 2 protrudes into this hole, possibly creating a 
DNA-binding surface [3].
 
From this structural information and results of various biochemical studies,
a possible mechanism has been proposed: DNA is first bound by the gyrB
dimer, then cleaved by gyrA. A large conformational change allows passage
of another DNA strand through the double-stranded break and into the protein
complex. This may involve ATP binding, exploiting the energy of association
of ATP to the complex to stabilise an unfavourable protein conformation.
The DNA break is then repaired by ligation, and the whole DNA molecule
released - this possibly involves hydrolysis of ATP to ADP and organic
phosphorous, which can dissociate from the protein, allowing the protein
complex to return to its favoured conformation, and releasing the DNA [3].
 
TPI2FAMILY is a 9-element fingerprint that provides a signature for the type
II DNA topoisomerase family. The fingerprint was derived from an initial 
alignment of 8 sequences: the motifs were drawn from conserved regions 
spanning virtually the full length of the gyrB domain - motif 5 includes the
region encoded by PROSITE pattern TOPOISOMERASE_II (PS0177), which contains
a well-conserved pentapeptide. Two iterations on OWL26.3 were required to 
reach convergence, at which point a true set comprising 47 sequences was
identified. Fifteen partial matches were also found, all of which were
topoisomerase II fragments.
 
An update on SPTR37_9f identified a true set of 82 sequences, and 7
partial matches.
Summary Information
  82 codes involving  9 elements
0 codes involving 8 elements
1 codes involving 7 elements
1 codes involving 6 elements
2 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
9828282828282828282
8000000000
7111111001
6000111111
5111121111
4000000000
3000000000
2000001001
123456789
True Positives
GYBR_STRSH    GYBS_STRSH    GYRB_AQUAE    GYRB_BACS5    
GYRB_BACSU GYRB_BARBA GYRB_BORBU GYRB_BUCAP
GYRB_CLOAB GYRB_ECOLI GYRB_HAEIN GYRB_HALSQ
GYRB_HELPY GYRB_MYCCA GYRB_MYCGA GYRB_MYCGE
GYRB_MYCHO GYRB_MYCLE GYRB_MYCPN GYRB_MYCSM
GYRB_MYCTU GYRB_NEIGO GYRB_PSEPU GYRB_SALTY
GYRB_SPICI GYRB_STAAU GYRB_STRCO GYRB_STRPN
GYRB_SYNY3 GYRB_TREDE GYRB_TREPA O41065
O55078 O55079 O59864 O62199
O68071 O69998 O74336 O84193
O84668 O86093 P77993 P95681
PARE_BACSU PARE_BORBU PARE_CAUCR PARE_ECOLI
PARE_HAEIN PARE_MYCGE PARE_MYCPN PARE_SALTY
PARE_STAAU PARE_STRPN Q59526 Q59957
TOP2_ARATH TOP2_ASFB7 TOP2_ASFM2 TOP2_BOMMO
TOP2_CAEEL TOP2_CANAL TOP2_CRIFA TOP2_DROME
TOP2_PEA TOP2_PLAFK TOP2_SCHPO TOP2_TRYBB
TOP2_TRYCR TOP2_YEAST TP2A_CHICK TP2A_CRIGR
TP2A_HUMAN TP2A_MOUSE TP2A_PIG TP2A_RAT
TP2B_CHICK TP2B_CRILO TP2B_HUMAN TP2B_MOUSE
TP2M_CAEEL TP2M_DICDI
True Positive Partials
Codes involving 7 elements
GYRB_MYXXA
Codes involving 6 elements
O29720
Codes involving 5 elements
Q27537 TOPL_BPT4
Codes involving 2 elements
TOPS_BPT4
Sequence Titles
GYBR_STRSH  DNA GYRASE SUBUNIT B, NOVOBIOCIN-RESISTANT (EC 5.99.1.3) - STREPTOMYCES SPHAEROIDES. 
GYBS_STRSH DNA GYRASE SUBUNIT B, NOVOBIOCIN-SENSITIVE (EC 5.99.1.3) - STREPTOMYCES SPHAEROIDES.
GYRB_AQUAE DNA GYRASE SUBUNIT B (EC 5.99.1.3) - AQUIFEX AEOLICUS.
GYRB_BACS5 DNA GYRASE SUBUNIT B (EC 5.99.1.3) - BACILLUS HALODURANS (BACILLUS SP. (STRAIN C-125)).
GYRB_BACSU DNA GYRASE SUBUNIT B (EC 5.99.1.3) - BACILLUS SUBTILIS.
GYRB_BARBA DNA GYRASE SUBUNIT B (EC 5.99.1.3) - BARTONELLA BACILLIFORMIS.
GYRB_BORBU DNA GYRASE SUBUNIT B (EC 5.99.1.3) - BORRELIA BURGDORFERI (LYME DISEASE SPIROCHETE).
GYRB_BUCAP DNA GYRASE SUBUNIT B (EC 5.99.1.3) - BUCHNERA APHIDICOLA.
GYRB_CLOAB DNA GYRASE SUBUNIT B (EC 5.99.1.3) - CLOSTRIDIUM ACETOBUTYLICUM.
GYRB_ECOLI DNA GYRASE SUBUNIT B (EC 5.99.1.3) - ESCHERICHIA COLI.
GYRB_HAEIN DNA GYRASE SUBUNIT B (EC 5.99.1.3) - HAEMOPHILUS INFLUENZAE.
GYRB_HALSQ DNA GYRASE SUBUNIT B (EC 5.99.1.3) - HALOFERAX SP. (STRAIN AA 2.2).
GYRB_HELPY DNA GYRASE SUBUNIT B (EC 5.99.1.3) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
GYRB_MYCCA DNA GYRASE SUBUNIT B (EC 5.99.1.3) - MYCOPLASMA CAPRICOLUM.
GYRB_MYCGA DNA GYRASE SUBUNIT B (EC 5.99.1.3) - MYCOPLASMA GALLISEPTICUM.
GYRB_MYCGE DNA GYRASE SUBUNIT B (EC 5.99.1.3) - MYCOPLASMA GENITALIUM.
GYRB_MYCHO DNA GYRASE SUBUNIT B (EC 5.99.1.3) - MYCOPLASMA HOMINIS.
GYRB_MYCLE DNA GYRASE SUBUNIT B (EC 5.99.1.3) - MYCOBACTERIUM LEPRAE.
GYRB_MYCPN DNA GYRASE SUBUNIT B (EC 5.99.1.3) - MYCOPLASMA PNEUMONIAE.
GYRB_MYCSM DNA GYRASE SUBUNIT B (EC 5.99.1.3) - MYCOBACTERIUM SMEGMATIS.
GYRB_MYCTU DNA GYRASE SUBUNIT B (EC 5.99.1.3) - MYCOBACTERIUM TUBERCULOSIS.
GYRB_NEIGO DNA GYRASE SUBUNIT B (EC 5.99.1.3) - NEISSERIA GONORRHOEAE.
GYRB_PSEPU DNA GYRASE SUBUNIT B (EC 5.99.1.3) - PSEUDOMONAS PUTIDA.
GYRB_SALTY DNA GYRASE SUBUNIT B (EC 5.99.1.3) - SALMONELLA TYPHIMURIUM.
GYRB_SPICI DNA GYRASE SUBUNIT B (EC 5.99.1.3) - SPIROPLASMA CITRI.
GYRB_STAAU DNA GYRASE SUBUNIT B (EC 5.99.1.3) - STAPHYLOCOCCUS AUREUS.
GYRB_STRCO DNA GYRASE SUBUNIT B (EC 5.99.1.3) - STREPTOMYCES COELICOLOR.
GYRB_STRPN DNA GYRASE SUBUNIT B (EC 5.99.1.3) - STREPTOCOCCUS PNEUMONIAE.
GYRB_SYNY3 DNA GYRASE SUBUNIT B (EC 5.99.1.3) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
GYRB_TREDE DNA GYRASE SUBUNIT B - TREPONEMA DENTICOLA.
GYRB_TREPA DNA GYRASE SUBUNIT B (EC 5.99.1.3) - TREPONEMA PALLIDUM.
O41065 PBCV-1 DNA TOPOISOMERASE II - PARAMECIUM BURSARIA CHLORELLA VIRUS 1 (PBCV-1).
O55078 DNA TOPOISOMERASE II ALPHA (EC 5.99.1.3) - CRICETULUS LONGICAUDATUS (LONG-TAILED HAMSTER) (CHINESE HAMSTER).
O55079 DNA TOPOISOMERASE II ALPHA (EC 5.99.1.3) - CRICETULUS LONGICAUDATUS (LONG-TAILED HAMSTER) (CHINESE HAMSTER).
O59864 TYPEII DNA TOPOISOMERASE - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS).
O62199 F32A11.4 PROTEIN - CAENORHABDITIS ELEGANS.
O68071 DNA GYRASE SUBUNIT B (EC 5.99.1.3) - RHODOBACTER CAPSULATUS (RHODOPSEUDOMONAS CAPSULATA).
O69998 PUTATIVE DNA GYRASE SUBUNIT B - STREPTOMYCES COELICOLOR.
O74336 DNA TOPOISOMERASE II - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O84193 DNA GYRASE SUBUNIT B - CHLAMYDIA TRACHOMATIS.
O84668 DNA GYRASE SUBUNIT B - CHLAMYDIA TRACHOMATIS.
O86093 DNA GYRASE B SUBUNIT - METHYLOVORUS SP. STRAIN SS1.
P77993 DNA TOPOISOMERASE II SUBUNIT B - THERMOTOGA MARITIMA.
P95681 DNA TOPOISOMERASE IV GRLB SUBUNIT - STAPHYLOCOCCUS AUREUS.
PARE_BACSU TOPOISOMERASE IV SUBUNIT B (EC 5.99.1.-) - BACILLUS SUBTILIS.
PARE_BORBU TOPOISOMERASE IV SUBUNIT B (EC 5.99.1.-) - BORRELIA BURGDORFERI (LYME DISEASE SPIROCHETE).
PARE_CAUCR TOPOISOMERASE IV SUBUNIT B (EC 5.99.1.-) - CAULOBACTER CRESCENTUS.
PARE_ECOLI TOPOISOMERASE IV SUBUNIT B (EC 5.99.1.-) - ESCHERICHIA COLI.
PARE_HAEIN TOPOISOMERASE IV SUBUNIT B (EC 5.99.1.-) - HAEMOPHILUS INFLUENZAE.
PARE_MYCGE TOPOISOMERASE IV SUBUNIT B (EC 5.99.1.-) - MYCOPLASMA GENITALIUM.
PARE_MYCPN TOPOISOMERASE IV SUBUNIT B (EC 5.99.1.-) - MYCOPLASMA PNEUMONIAE.
PARE_SALTY TOPOISOMERASE IV SUBUNIT B (EC 5.99.1.-) - SALMONELLA TYPHIMURIUM.
PARE_STAAU TOPOISOMERASE IV SUBUNIT B (EC 5.99.1.-) - STAPHYLOCOCCUS AUREUS.
PARE_STRPN TOPOISOMERASE IV SUBUNIT B (EC 5.99.1.-) - STREPTOCOCCUS PNEUMONIAE.
Q59526 TOPOISOMERASE II SUBUNIT B (EC 5.99.1.3) - MYCOPLASMA GALLISEPTICUM.
Q59957 DNA GYRASE - STREPTOCOCCUS PNEUMONIAE.
TOP2_ARATH DNA TOPOISOMERASE II (EC 5.99.1.3) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
TOP2_ASFB7 DNA TOPOISOMERASE II (EC 5.99.1.3) - AFRICAN SWINE FEVER VIRUS (STRAIN BA71V) (ASFV).
TOP2_ASFM2 DNA TOPOISOMERASE II (EC 5.99.1.3) - AFRICAN SWINE FEVER VIRUS (ISOLATE MALAWI LIL 20/1) (ASFV).
TOP2_BOMMO DNA TOPOISOMERASE II (EC 5.99.1.3) (TOPOII) - BOMBYX MORI (SILK MOTH).
TOP2_CAEEL PROBABLE DNA TOPOISOMERASE II (EC 5.99.1.3) - CAENORHABDITIS ELEGANS.
TOP2_CANAL DNA TOPOISOMERASE II (EC 5.99.1.3) - CANDIDA ALBICANS (YEAST).
TOP2_CRIFA DNA TOPOISOMERASE II (EC 5.99.1.3) - CRITHIDIA FASCICULATA.
TOP2_DROME DNA TOPOISOMERASE II (EC 5.99.1.3) - DROSOPHILA MELANOGASTER (FRUIT FLY).
TOP2_PEA DNA TOPOISOMERASE II (EC 5.99.1.3) - PISUM SATIVUM (GARDEN PEA).
TOP2_PLAFK DNA TOPOISOMERASE II (EC 5.99.1.3) - PLASMODIUM FALCIPARUM (ISOLATE K1 / THAILAND).
TOP2_SCHPO DNA TOPOISOMERASE II (EC 5.99.1.3) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
TOP2_TRYBB DNA TOPOISOMERASE II (EC 5.99.1.3) - TRYPANOSOMA BRUCEI BRUCEI.
TOP2_TRYCR DNA TOPOISOMERASE II (EC 5.99.1.3) - TRYPANOSOMA CRUZI.
TOP2_YEAST DNA TOPOISOMERASE II (EC 5.99.1.3) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
TP2A_CHICK DNA TOPOISOMERASE II, ALPHA ISOZYME (EC 5.99.1.3) - GALLUS GALLUS (CHICKEN).
TP2A_CRIGR DNA TOPOISOMERASE II, ALPHA ISOZYME (EC 5.99.1.3) - CRICETULUS GRISEUS (CHINESE HAMSTER).
TP2A_HUMAN DNA TOPOISOMERASE II, ALPHA ISOZYME (EC 5.99.1.3) - HOMO SAPIENS (HUMAN).
TP2A_MOUSE DNA TOPOISOMERASE II, ALPHA (EC 5.99.1.3) - MUS MUSCULUS (MOUSE).
TP2A_PIG DNA TOPOISOMERASE II, ALPHA (EC 5.99.1.3) - SUS SCROFA (PIG).
TP2A_RAT DNA TOPOISOMERASE II, ALPHA (EC 5.99.1.3) - RATTUS NORVEGICUS (RAT).
TP2B_CHICK DNA TOPOISOMERASE II, BETA ISOZYME (EC 5.99.1.3) - GALLUS GALLUS (CHICKEN).
TP2B_CRILO DNA TOPOISOMERASE II, BETA ISOZYME (EC 5.99.1.3) - CRICETULUS LONGICAUDATUS (LONG-TAILED HAMSTER) (CHINESE HAMSTER).
TP2B_HUMAN DNA TOPOISOMERASE II, BETA ISOZYME (EC 5.99.1.3) - HOMO SAPIENS (HUMAN).
TP2B_MOUSE DNA TOPOISOMERASE II, BETA ISOZYME (EC 5.99.1.3) - MUS MUSCULUS (MOUSE).
TP2M_CAEEL PUTATIVE DNA TOPOISOMERASE II, MITOCHONDRIAL PRECURSOR (EC 5.99.1.3) - CAENORHABDITIS ELEGANS.
TP2M_DICDI DNA TOPOISOMERASE II, MITOCHONDRIAL PRECURSOR (EC 5.99.1.3) - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).

GYRB_MYXXA DNA GYRASE SUBUNIT B (EC 5.99.1.3) - MYXOCOCCUS XANTHUS.

O29720 DNA GYRASE, SUBUNIT B (GYRB) - ARCHAEOGLOBUS FULGIDUS.

Q27537 SIMILARITY TO DNA TOPOISOMERASE II - CAENORHABDITIS ELEGANS.
TOPL_BPT4 DNA TOPOISOMERASE LARGE SUBUNIT (EC 5.99.1.3) (PROTEIN GP39) - BACTERIOPHAGE T4.

TOPS_BPT4 DNA TOPOISOMERASE SMALL SUBUNIT (EC 5.99.1.3) (PROTEIN GP60) - BACTERIOPHAGE T4.
Scan History
OWL26_3    2  100  NSINGLE    
SPTR37_9f 2 250 NSINGLE
Initial Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
ALLKIFDELIVNATDH TOP2_ASFB7 53 53 -
GLYKIFDEILVNAADN TOPA_HUMAN 80 80 -
GLHHLVWEIVDNSIDE GYRB_BACSU 37 37 -
GLHHMVFEVLDNAIDE GYRB_NEIGO 39 39 -
GLHHLVYEVVDNSIDE GYRB_HALSQ 36 36 -
GLLKIFDEILVNAADN TOP2_CAEEL 111 111 -
RPNHLGQEVIDNSVDE PARE_ECOLI 31 31 -
GLFKIFDEILVNAADN TOP2_YEAST 59 59 -

Motif 2 width=14
Element Seqn Id St Int Rpt
TVVDNGRGIPVGIH GYRB_BACSU 72 19 -
SVADNGRGMPTGIH GYRB_NEIGO 74 19 -
SVTDNGRGIPVGTH GYRB_HALSQ 71 19 -
SVWNNGSGLPVEIH TOP2_CAEEL 148 21 -
EVIDDGRGMPVDIH PARE_ECOLI 66 19 -
EVKNDGKGIPIEIH TOP2_YEAST 97 22 -
SCENDGPGIPIAKH TOP2_ASFB7 92 23 -
SIWNNGKGIPVVEH TOPA_HUMAN 116 20 -

Motif 3 width=15
Element Seqn Id St Int Rpt
GGLHGVGASVVNALS GYRB_BACSU 115 29 -
GGLHGVGVTVVNALS GYRB_HALSQ 114 29 -
GGRNGYGAKLCNIFS TOPA_HUMAN 159 29 -
GGTNGVGLKLAMVHS TOP2_ASFB7 141 35 -
GGRNGYGAKLCNIFS TOP2_YEAST 140 29 -
GGLHGVGISVVNALS PARE_ECOLI 109 29 -
GGRNGYGAKLCNIFS TOP2_CAEEL 191 29 -
GGLHGVGVSVVNALS GYRB_NEIGO 117 29 -

Motif 4 width=14
Element Seqn Id St Int Rpt
SIINGVNCVKGEHV TOP2_ASFB7 302 146 -
SFVNSIATSKGGRH TOPA_HUMAN 311 137 -
SFTNNINTYEGGTH GYRB_BACSU 272 142 -
CFTNNIPQRDGGTH GYRB_NEIGO 271 139 -
AFANNINTREGGTH GYRB_HALSQ 272 143 -
SFVNNINTEKGGSH TOP2_CAEEL 347 141 -
SYVNLIPTMQGGTH PARE_ECOLI 266 142 -
SFVNSIATTMGGTH TOP2_YEAST 304 149 -

Motif 5 width=15
Element Seqn Id St Int Rpt
LILTEGDSAKALALA TOP2_CAEEL 493 132 -
LFLVEGDSAGGSAKQ PARE_ECOLI 414 134 -
LVLTEGDSALSLAVA TOP2_YEAST 446 128 -
LLAAEGDSALSLLRT TOP2_ASFB7 434 118 -
LYIVEGDSAGGSAKQ GYRB_BACSU 424 138 -
LILTEGDSAKTLAVS TOPA_HUMAN 456 131 -
LYLVEGNSAGGSAMQ GYRB_NEIGO 423 138 -
LFIVEGDSAGGSAKQ GYRB_HALSQ 425 139 -

Motif 6 width=17
Element Seqn Id St Int Rpt
SLRYGRLLILADQDEDG TOP2_CAEEL 564 56 -
SLRYGHLMIMTDQDHDG TOP2_YEAST 516 55 -
KLRYGCIVACVDQDLDG TOP2_ASFB7 528 79 -
TLRYGKIMIMTDQDQDG TOPA_HUMAN 529 58 -
KARYHKVVIMTDADVDG GYRB_BACSU 490 51 -
KLRYHRIIIMTDADVDG GYRB_NEIGO 476 38 -
KARYQRLILMTDADVDG GYRB_HALSQ 491 51 -
QLRYGKICILADADSDG PARE_ECOLI 479 50 -

Motif 7 width=18
Element Seqn Id St Int Rpt
HIATLLCALFVKHFRALV PARE_ECOLI 497 1 -
KILGLLLAYFHLFWPQLI TOP2_ASFB7 547 2 -
HIKGLLINFIHHNWPSLL TOPA_HUMAN 547 1 -
HIRTLLLTFFYRYMRQII GYRB_BACSU 508 1 -
HIRTLLLTFFYRQMPDLV GYRB_NEIGO 494 1 -
HIRTLLLTLLYRHMRPLI GYRB_HALSQ 509 1 -
HIKGLIVNFIHKFWPSLV TOP2_CAEEL 582 1 -
HIKGLIINFLESSFLGLL TOP2_YEAST 534 1 -

Motif 8 width=13
Element Seqn Id St Int Rpt
GFLLEFITPIIKV TOP2_YEAST 555 3 -
RFLEEFITPIVKV TOPA_HUMAN 567 2 -
GYVYIAQPPLYKV GYRB_BACSU 528 2 -
GYIYIAQPPLYKA GYRB_NEIGO 514 2 -
GYVYAAQPPLYRV GYRB_HALSQ 529 2 -
GFIQSFRTPLLKA TOP2_CAEEL 603 3 -
GHVYVALPPLYRI PARE_ECOLI 517 2 -
GFVKRLLTPLIRV TOP2_ASFB7 567 2 -

Motif 9 width=17
Element Seqn Id St Int Rpt
VQRFKGLGEMNPDQLWD GYRB_HALSQ 571 29 -
VQRFKGLGEMNPMQLRE PARE_ECOLI 560 30 -
QKYYKGLGTSLAQEVRE TOP2_YEAST 600 32 -
VKYYKGLAAHDTHEVKS TOP2_ASFB7 611 31 -
LQRYKGLGEMNATQLWE GYRB_BACSU 570 29 -
VKYYKGLGTSTSKEAKE TOPA_HUMAN 609 29 -
IQRYKGLGEMNPEQLWE GYRB_NEIGO 714 187 -
IKYYKGLGTSTSNEARE TOP2_CAEEL 644 28 -
Final Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
GLHHLVWEIVDNSIDE GYRB_BACS5 37 37 -
GLHHLVWEIVDNSIDE GYRB_SPICI 34 34 -
GLHHLIWEILDNAVDE GYRB_AQUAE 41 41 -
GLHHLVWEIVDNSIDE GYRB_BACSU 37 37 -
GLHHLVYEIVDNSIDE GYRB_CLOAB 37 37 -
GLHHMIWEIIDNSIDE GYRB_MYCPN 39 39 -
GLHHLVYEVVDNSVDE P77993 33 33 -
GLHHMVFEVVDNAIDE GYRB_HAEIN 39 39 -
GLHHMVYEVVDNAVDE GYRB_HELPY 33 33 -
GLHHMVFEVVDNAIDE GYRB_SALTY 34 34 -
GLHHMIWEIVDNSIDE GYRB_MYCGE 39 39 -
GLHHMVFEVVDNAIDE GYRB_ECOLI 34 34 -
GLHHMVFEVVDNSIDE GYRB_PSEPU 37 37 -
GLHHLVYEVVDNSIDE GYRB_BORBU 37 37 -
GLHHMIWEIIDNSVDE GYRB_MYCGA 38 38 -
GLHHLLWEIVDNSVDE GYRB_MYCHO 39 39 -
GLHHLVYEVVDNCIDE GYRB_TREDE 35 35 -
GLHHLVWEIVDNSIDE GYRB_STAAU 42 42 -
GLHHLVYEIVDNSVDE PARE_BACSU 38 38 -
GLHHMVFEIVDNSIDE GYRB_BUCAP 35 35 -
GLHHMVFEVLDNAIDE GYRB_NEIGO 39 39 -
GLHHMVFEVLDNAIDE O86093 34 34 -
GLHHLVWEIVDNAVDE PARE_STRPN 40 40 -
GLHHLIWEVVDNAVDE GYRB_MYCTU 52 52 -
GLHHLVWEIVDNSIDE Q59957 42 42 -
GLHHLIWEVVDNSVDE GYRB_MYCLE 59 59 -
GLHHLVWEIVDNSIDE GYRB_STRPN 42 42 -
GLHHLIWEVVDNAVDE GYRB_MYCSM 41 41 -
GLHHLVYEIVDNSVDE P95681 36 36 -
GLHHLVYEIVDNSVDE PARE_STAAU 36 36 -
GLHHMLWEILANSVDE PARE_MYCGE 34 34 -
GLHHLVWEIVDNAIDE GYRB_MYCCA 36 36 -
GLHHLVYEVVDNSIDE O84193 37 37 -
GLHHLVTEVVDNSVDE GYBS_STRSH 55 55 -
GLHHLVYEVVDNCIDE GYRB_TREPA 34 34 -
GLHHLVQEVVDNSVDE GYRB_STRCO 62 62 -
GLHHLVYEVVDNSIDE GYRB_HALSQ 36 36 -
GFHHLLWEILDNCVDE PARE_MYCPN 34 34 -
GLHHLVWELFDNAVDE Q59526 34 34 -
GLHHLVQELVDNSVDE GYBR_STRSH 55 55 -
GLYKIFDEILVNAADN TP2B_CRILO 89 89 -
GLYKIFDEILVNAADN TP2B_HUMAN 101 101 -
GLYKIFDEILVNAADN TP2B_MOUSE 89 89 -
GLYKIFDEILVNAADN TP2B_CHICK 106 106 -
GLHHLVYEVVDNAIDE GYRB_SYNY3 37 37 -
GLYKIFDEILVNAADN TP2A_CHICK 81 81 -
ALHHLFSEIIDNAMDE GYRB_BARBA 82 82 -
ALHHLFAEVLDNSMDE PARE_CAUCR 56 56 -
GLYKIFDEILVNAADN O55078 79 79 -
GLYKIFDEILVNAADN TP2A_RAT 79 79 -
GLYKIFDEILVNAADN TP2A_PIG 80 80 -
GLYKIFDEILVNAADN TP2A_MOUSE 79 79 -
GLYKIFDEILVNAADN TP2A_HUMAN 80 80 -
GLYKIFDEILVNAADN TP2A_CRIGR 79 79 -
GLYKIFDEILVNAADN O55079 79 79 -
ALHHMVAEILDNAMDE O68071 43 43 -
GLMHCLWEIIDNSVDE O69998 52 52 -
GLYKIFDEILVNAADN TOP2_DROME 61 61 -
GLYKIYDEILVNAADN TOP2_BOMMO 88 88 -
GLLKIFDEILVNAADN TOP2_CAEEL 111 111 -
GLYKIFDEILVNAADN TOP2_ARATH 80 80 -
RPNHLAQEVIDNSVDE PARE_HAEIN 31 31 -
RPNHLGQEVIDNSVDE PARE_SALTY 31 31 -
GLYKIFDEIVVNAADN O59864 107 107 -
RPNHLGQEVIDNSVDE PARE_ECOLI 31 31 -
GLFKIYDEILVNAADN O62199 113 113 -
GLLKIYDEILVNAADN TP2M_DICDI 172 172 -
GLYKIFDEILVNAADN TOP2_CANAL 109 109 -
GLFKIFDEILVNAADN TOP2_YEAST 59 59 -
GLYKIFDEIIVNAADV TOP2_PLAFK 58 58 -
GLYKIFDEILVNAADN TOP2_PEA 68 68 -
GLYKIFDEIIVNAADN O74336 125 125 -
GLYKIFDEIIVNAADN TOP2_SCHPO 71 71 -
GLLKIFDEILVNAADN TP2M_CAEEL 111 111 -
GLLKIVDEILLNASDN TOP2_TRYBB 54 54 -
GIYVLIKEIIDNSIDE PARE_BORBU 40 40 -
GLLKIVDEILLNASDN TOP2_TRYCR 54 54 -
GLLKIVDEILLNAADN TOP2_CRIFA 54 54 -
GIYTLFKEVVDNAIDE O84668 41 41 -
ALLKIFDEIITNSADC O41065 49 49 -
ALLKIFDELIVNATDH TOP2_ASFB7 53 53 -
ALLKIFDELIVNATDH TOP2_ASFM2 53 53 -

Motif 2 width=14
Element Seqn Id St Int Rpt
TVTDNGRGIPVGIH GYRB_BACS5 72 19 -
TVIDNGRGIPIEIH GYRB_SPICI 69 19 -
TVEDDGRGIPVDIH GYRB_AQUAE 76 19 -
TVVDNGRGIPVGIH GYRB_BACSU 72 19 -
TVSDDGRGMPIGIH GYRB_CLOAB 72 19 -
IVEDDGRGIPVDIH GYRB_MYCPN 74 19 -
EVEDNGRGIPVDIH P77993 68 19 -
SVQDDGGGIPVDIH GYRB_HAEIN 74 19 -
IVEDNGRGIPVDIH GYRB_HELPY 68 19 -
SVTDDGRGIPTGIH GYRB_SALTY 69 19 -
RVEDDGRGIPVDIH GYRB_MYCGE 74 19 -
SVQDDGRGIPTGIH GYRB_ECOLI 69 19 -
SVRDNGRGIPVDVH GYRB_PSEPU 72 19 -
TVIDNGRGIPTDIH GYRB_BORBU 72 19 -
EVEDDGRGIPVDIH GYRB_MYCGA 73 19 -
EVEDNGRGMPTGIH GYRB_MYCHO 74 19 -
RVEDNGRGIPVDIH GYRB_TREDE 70 19 -
KVTDNGRGIPVDIQ GYRB_STAAU 77 19 -
SVQDRGRGMPTGMH PARE_BACSU 73 19 -
SIKDDGRGIPTDIH GYRB_BUCAP 70 19 -
SVADNGRGMPTGIH GYRB_NEIGO 74 19 -
SISDNGRGIPTDIK O86093 69 19 -
TVQDHGRGMPTGMH PARE_STRPN 75 19 -
EVADDGRGIPVATH GYRB_MYCTU 87 19 -
TVVDDGRGIPVDIQ Q59957 77 19 -
EVADNGRGIPVAVH GYRB_MYCLE 94 19 -
TVVDDGRGIPVGIQ GYRB_STRPN 77 19 -
EVRDDGRGIPVEMH GYRB_MYCSM 76 19 -
SIEDNGRGMPTGIH P95681 71 19 -
SIEDNGRGMPTGIH PARE_STAAU 71 19 -
TVSDDGRGIPYEIH PARE_MYCGE 69 19 -
TVIDNGRGIPTGMH GYRB_MYCCA 71 19 -
SISDNGRGIPIQIH O84193 72 19 -
RVVDNGRGIPVGIV GYBS_STRSH 90 19 -
RVEDNGRGIPVDVH GYRB_TREPA 69 19 -
RVVDNGRGIPVGIV GYRB_STRCO 97 19 -
SVTDNGRGIPVGTH GYRB_HALSQ 71 19 -
TVSDNGRGIPFETH PARE_MYCPN 69 19 -
IVTDNGRGIPVGKN Q59526 69 19 -
RVVDNGRGIPVGMH GYBR_STRSH 90 19 -
SIWNNGKGIPVVEH TP2B_CRILO 126 21 -
SIWNNGKGIPVVEH TP2B_HUMAN 138 21 -
SIWNNGKGIPVVEH TP2B_MOUSE 126 21 -
SIWNNGKGIPVVEH TP2B_CHICK 143 21 -
TVVDNGRGIPTDIH GYRB_SYNY3 72 19 -
SVWNNGKGIPVVEH TP2A_CHICK 118 21 -
TVTDNGRGIPIENH GYRB_BARBA 117 19 -
SVKDDGRGMPVDPH PARE_CAUCR 91 19 -
SIWNNGKGIPVVEH O55078 116 21 -
SIWNNGKGIPVVEH TP2A_RAT 115 20 -
SIWNNGKGIPVVEH TP2A_PIG 117 21 -
SIWNNGKGIPVVEH TP2A_MOUSE 116 21 -
SIWNNGKGIPVVEH TP2A_HUMAN 117 21 -
SIWNNGKGIPVVEH TP2A_CRIGR 116 21 -
SIWNNGKGIPVVEH O55079 116 21 -
TVRDNGRGIPVDPH O68071 78 19 -
EVRDNGRGIPVDVE O69998 87 19 -
SVWNNGQGIPVTMH TOP2_DROME 98 21 -
SVYNNGSGIPVVMH TOP2_BOMMO 125 21 -
SVWNNGSGLPVEIH TOP2_CAEEL 148 21 -
SVCNSGAGVPVEIH TOP2_ARATH 117 21 -
EVTDNGRGMPVDIH PARE_HAEIN 66 19 -
EVIDDGRGMPVDIH PARE_SALTY 66 19 -
SVWNNGKGIPVEMH O59864 144 21 -
EVIDDGRGMPVDIH PARE_ECOLI 66 19 -
SVYNNGKGIPVTQH O62199 150 21 -
SIMNDGKGIPVVMH TP2M_DICDI 209 21 -
EVMNDGKGIPIEMH TOP2_CANAL 146 21 -
EVKNDGKGIPIEIH TOP2_YEAST 97 22 -
SVYNDGEGIPVDIH TOP2_PLAFK 100 26 -
SVYNNGDGVPVEIH TOP2_PEA 105 21 -
SIYNNGKGIPIEIH O74336 162 21 -
SIYNNGKGIPIEIH TOP2_SCHPO 108 21 -
SVWNNGSGLPVEIH TP2M_CAEEL 148 21 -
TIENDGAGIPIVRS TOP2_TRYBB 91 21 -
SIRDYGRGIPLGKV PARE_BORBU 74 18 -
TIENDGAGIPIVRS TOP2_TRYCR 91 21 -
MVENDGAGLPIVKS TOP2_CRIFA 93 23 -
SIRDEGRGIPLGKV O84668 75 18 -
SVHNDGCNIPIEKH O41065 84 19 -
SCENDGPGIPIAKH TOP2_ASFB7 92 23 -
ACENDGPGIPIAKH TOP2_ASFM2 92 23 -

Motif 3 width=15
Element Seqn Id St Int Rpt
GGLHGVGASVVNALS GYRB_BACS5 115 29 -
GGLHGVGASVVNALS GYRB_SPICI 112 29 -
GGLHGVGASVVNALS GYRB_AQUAE 119 29 -
GGLHGVGASVVNALS GYRB_BACSU 115 29 -
GGLHGVGASVVNALS GYRB_CLOAB 115 29 -
GGLHGVGASVVNALS GYRB_MYCPN 117 29 -
GGLHGVGVSVVNALS P77993 111 29 -
GGLHGVGVSVVNALS GYRB_HAEIN 117 29 -
GGLHGVGVSVVNALS GYRB_HELPY 111 29 -
GGLHGVGVSVVNALS GYRB_SALTY 112 29 -
GGLHGVGASVVNALS GYRB_MYCGE 117 29 -
GGLHGVGVSVVNALS GYRB_ECOLI 112 29 -
GGLHGVGVSVVNALS GYRB_PSEPU 115 29 -
GGLHGVGISVVNALS GYRB_BORBU 115 29 -
GGLHGVGASVVNALS GYRB_MYCGA 116 29 -
GGLHGVGASVVNALS GYRB_MYCHO 117 29 -
GGLHGVGVSVVNALS GYRB_TREDE 113 29 -
GGLHGVGSSVVNALS GYRB_STAAU 120 29 -
GGLHGVGASVVNALS PARE_BACSU 115 28 -
GGLHGVGISVVNALS GYRB_BUCAP 113 29 -
GGLHGVGVSVVNALS GYRB_NEIGO 117 29 -
GGLHGVGVSVVNALS O86093 116 33 -
GGLHGVGSSVVNALS PARE_STRPN 117 28 -
GGLHGVGVSVVNALS GYRB_MYCTU 129 28 -
GGLHGVGSSVVNALS Q59957 120 29 -
GGLHGVGVSVVNALS GYRB_MYCLE 138 30 -
GGLHGVGLSVVNALS GYRB_STRPN 120 29 -
GGLHGVGVSVVNALS GYRB_MYCSM 118 28 -
GGLHGVGASVVNALS P95681 113 28 -
GGLHGVGASVVNALS PARE_STAAU 113 28 -
GGLHGVGASVVNALS PARE_MYCGE 112 29 -
GGLHGVGSSVTNALS GYRB_MYCCA 113 28 -
GGLHGVGVSCVNALS O84193 121 35 -
GGLHGVGVSVVNALS GYBS_STRSH 133 29 -
GGLHGVGVSVVNALS GYRB_TREPA 112 29 -
GGLHGVGVSVVNALS GYRB_STRCO 140 29 -
GGLHGVGVTVVNALS GYRB_HALSQ 114 29 -
GGLHGVGASVVNALS PARE_MYCPN 112 29 -
GGLHGVGASVVNALS Q59526 112 29 -
GGLHGVGLSVVNALS GYBR_STRSH 133 29 -
GGRNGYGAKLCNIFS TP2B_CRILO 169 29 -
GGRNGYGAKLCNIFS TP2B_HUMAN 181 29 -
GGRNGYGAKLCNIFS TP2B_MOUSE 169 29 -
GGRNGYGAKLCNIFS TP2B_CHICK 186 29 -
GGLHGVGVSVVNALS GYRB_SYNY3 115 29 -
GGRNGYGAKLCNIFS TP2A_CHICK 161 29 -
GGLHGVGISVVNALS GYRB_BARBA 161 30 -
GGLHGVGASVVNALS PARE_CAUCR 135 30 -
GGRNGYGAKLCNIFS O55078 159 29 -
GGRNGYGAKLCNIFS TP2A_RAT 158 29 -
GGRNGYGAKLCNIFS TP2A_PIG 160 29 -
GGRNGYGAKLCNIFS TP2A_MOUSE 159 29 -
GGRNGYGAKLCNIFS TP2A_HUMAN 160 29 -
GGRNGYGAKLCNIFS TP2A_CRIGR 159 29 -
GGRNGYGAKLCNIFS O55079 159 29 -
GGLNGVGSSVVNALS O68071 122 30 -
GGLHGVGASVVNALS O69998 130 29 -
GGRNGYGAKLCNIFS TOP2_DROME 141 29 -
GGRNGYGAKLCNIFS TOP2_BOMMO 168 29 -
GGRNGYGAKLCNIFS TOP2_CAEEL 191 29 -
GGRNGYGAKLTNIFS TOP2_ARATH 160 29 -
GGLHGVGISVVNALS PARE_HAEIN 109 29 -
GGLHGVGISVVNALS PARE_SALTY 109 29 -
GGRNGFGAKLCNVFS O59864 187 29 -
GGLHGVGISVVNALS PARE_ECOLI 109 29 -
GGRNGYGAKLCNIFS O62199 193 29 -
GGRNGFGAKLTNIFS TP2M_DICDI 252 29 -
GGRNGFGAKLCNIFS TOP2_CANAL 189 29 -
GGRNGYGAKLCNIFS TOP2_YEAST 140 29 -
GGRNGFGAKLTNIFS TOP2_PLAFK 143 29 -
GGRNGYGAKLTNIFS TOP2_PEA 148 29 -
GGRNGYGAKLCNIFS O74336 205 29 -
GGRNGYGAKLCNIFS TOP2_SCHPO 151 29 -
GGRNGYGAKLCNIFS TP2M_CAEEL 191 29 -
AGRHGYGAKLTNILS TOP2_TRYBB 134 29 -
VGLNGVGTKAVNALS PARE_BORBU 109 21 -
AGRHGYGAKLTNILS TOP2_TRYCR 134 29 -
AGRHGYGAKLTNILS TOP2_CRIFA 136 29 -
VGLNGVGLKAVNALS O84668 110 21 -
AGRNGIGSKATNIFS O41065 127 29 -
GGTNGVGLKLAMVHS TOP2_ASFB7 141 35 -
GGTNGVGLKLAMVHS TOP2_ASFM2 141 35 -

Motif 4 width=14
Element Seqn Id St Int Rpt
SFANNINTHEGGTH GYRB_BACS5 271 141 -
SFCNNINTHEGGTH GYRB_SPICI 271 144 -
SFVNNIKTVEGGTH GYRB_AQUAE 273 139 -
SFTNNINTYEGGTH GYRB_BACSU 272 142 -
SFANNIHTIEGGTH GYRB_CLOAB 270 140 -
SFCNNINTTEGGTH GYRB_MYCPN 285 153 -
SFANTIKTVDGGTH P77993 272 146 -
CFTNNIPQRDGGTH GYRB_HAEIN 271 139 -
SFVNNIKTSEGGTH GYRB_HELPY 268 142 -
CFTNNIPQRDGGTH GYRB_SALTY 267 140 -
SFCNNINTTEGGTH GYRB_MYCGE 285 153 -
CFTNNIPQRDGGTH GYRB_ECOLI 267 140 -
CFTNNIPQRDGGTH GYRB_PSEPU 270 140 -
SFVNNINTREGGTH GYRB_BORBU 271 141 -
SFCNNIHTNQGGTH GYRB_MYCGA 284 153 -
SYANNIQTIDGGTH GYRB_MYCHO 282 150 -
SFVNDINTREGGTH GYRB_TREDE 270 142 -
TYANNIHTYEGGTH GYRB_STAAU 278 143 -
SFVNNVRTKDGGTH PARE_BACSU 269 139 -
CFTNNIPQKDGGTH GYRB_BUCAP 268 140 -
CFTNNIPQRDGGTH GYRB_NEIGO 271 139 -
CFTNNIPQRDGGTH O86093 270 139 -
SFVNNVRTKDGGTH PARE_STRPN 273 141 -
TFANTINTHEGGTH GYRB_MYCTU 314 170 -
SFANNIHTHEGGTH Q59957 277 142 -
TFANTINTHEGGTH GYRB_MYCLE 325 172 -
SFANNIHTHEGGTH GYRB_STRPN 277 142 -
TFANTINTHEGGTH GYRB_MYCSM 303 170 -
SFVNNVRTKDGGTH P95681 270 142 -
SFVNNVRTKDGGTH PARE_STAAU 270 142 -
SFANSIKTFEGGSH PARE_MYCGE 266 139 -
GFANNVKTIDGGTH GYRB_MYCCA 267 139 -
SYANNIPTRQGGTH O84193 281 145 -
SFANTIHTHEGGTH GYBS_STRSH 313 165 -
SFVNDINTREGGTH GYRB_TREPA 269 142 -
SFANIIHTHEGGTH GYRB_STRCO 315 160 -
AFANNINTREGGTH GYRB_HALSQ 272 143 -
SFANSIRTSEGGSH PARE_MYCPN 269 142 -
SFANSVKTSEGGSH Q59526 267 140 -
SYANAIHTHEGGTH GYBR_STRSH 306 158 -
SFVNSIATTKGGRH TP2B_CRILO 321 137 -
SFVNSIATTKGGRH TP2B_HUMAN 333 137 -
SFVNSIATTKGGRH TP2B_MOUSE 321 137 -
SFVNSIATTKGGRH TP2B_CHICK 338 137 -
GFANNIRTIDGGTH GYRB_SYNY3 274 144 -
SFVNSIATTKGGRH TP2A_CHICK 313 137 -
SYCNTIPTEEGGTH GYRB_BARBA 326 150 -
SYCNTVPTPEGGTH PARE_CAUCR 302 152 -
SFVNSIATSKGGRH O55078 311 137 -
SFVNSIATSKGGRH TP2A_RAT 310 137 -
SFVNSIATSKGGRH TP2A_PIG 312 137 -
SFVNSIATSKGGRH TP2A_MOUSE 311 137 -
SFVNSIATSKGGRH TP2A_HUMAN 312 137 -
SFVNSIATSKGGRH TP2A_CRIGR 311 137 -
SFVNSIATSKGGRH O55079 311 137 -
SYCNTVPTPEGGTH O68071 286 149 -
SFVNIIATPKGGTH O69998 326 181 -
SFVNSIATYKGGRH TOP2_DROME 293 137 -
SFVNSIATTKGGKH TOP2_BOMMO 321 138 -
SFVNNINTEKGGSH TOP2_CAEEL 347 141 -
SFVNSIATIKGGTH TOP2_ARATH 315 140 -
SYVNLIPTIQGGTH PARE_HAEIN 266 142 -
SYVNLIPTMQGGTH PARE_SALTY 266 142 -
SFVNSIATTSGGTH O59864 342 140 -
SYVNLIPTMQGGTH PARE_ECOLI 266 142 -
SFANNVSTTKGGRH O62199 344 136 -
SFVNSINTVKGGTH TP2M_DICDI 414 147 -
SFVNSIATTSGGTH TOP2_CANAL 352 148 -
SFVNSIATTMGGTH TOP2_YEAST 304 149 -
SFVNSICTTKGGSH TOP2_PLAFK 347 189 -
SFVNSIATIKGGTH TOP2_PEA 302 139 -
SFVNNISTIRGGTH O74336 358 138 -
SFVNNISTIRGGTH TOP2_SCHPO 304 138 -
SFVNNINTEKGGSH TP2M_CAEEL 347 141 -
GVVNGVVTYNGGTH TOP2_TRYBB 288 139 -
SFVNGQYTNDGGTH PARE_BORBU 251 127 -
GVVNGVVTHNGGTH TOP2_TRYCR 288 139 -
GVVNGVVTYNGGTH TOP2_CRIFA 290 139 -
SFVNGQETTDGGTH O84668 251 126 -
SFVNSVVTRGGTHV O41065 271 129 -
SIINGVNCVKGEHV TOP2_ASFB7 302 146 -
SIINGVNCVKGEHV TOP2_ASFM2 302 146 -

Motif 5 width=15
Element Seqn Id St Int Rpt
IYIVEGDSAGGSAKQ GYRB_BACS5 423 138 -
LYIVEGDSAGGSAKS GYRB_SPICI 425 140 -
IFLVEGDSAGGSAKQ GYRB_AQUAE 425 138 -
LYIVEGDSAGGSAKQ GYRB_BACSU 424 138 -
IYIVEGDSAGGSAKQ GYRB_CLOAB 422 138 -
LYIVEGDSAGGTAKT GYRB_MYCPN 437 138 -
LFIVEGDSAGGSAKQ P77993 423 137 -
LYLVEGDSAGGSAKV GYRB_HAEIN 423 138 -
IFLVEGDSAGGSAKQ GYRB_HELPY 418 136 -
LYLVEGDSAGGSAKQ GYRB_SALTY 419 138 -
LYIVEGDSAGGTAKT GYRB_MYCGE 437 138 -
LYLVEGDSAGGSAKQ GYRB_ECOLI 419 138 -
LYLVEGDSAGGSAKQ GYRB_PSEPU 422 138 -
IYIVEGDSAGGSAKM GYRB_BORBU 423 138 -
LYIVEGDSAGGSAKS GYRB_MYCGA 433 135 -
LFIVEGNSAGGSAKM GYRB_MYCHO 434 138 -
VYIVEGDSAGGSAKK GYRB_TREDE 425 141 -
IFLVEGDSAGGSTKS GYRB_STAAU 430 138 -
LYLVEGDSAGGSAKQ PARE_BACSU 425 142 -
IYLVEGDSAGGSAKQ GYRB_BUCAP 420 138 -
LYLVEGNSAGGSAMQ GYRB_NEIGO 423 138 -
LYLVEGDSAGGSAKQ O86093 422 138 -
LYLVEGDSAGGSAKQ PARE_STRPN 429 142 -
LYVVEGDSAGGSAKS GYRB_MYCTU 466 138 -
LFIVEGDSAGGSAKS Q59957 429 138 -
LYVVEGDSAGGSAKS GYRB_MYCLE 477 138 -
LFIVEGDSAGGSAKS GYRB_STRPN 429 138 -
LYVVEGDSAGGSAKS GYRB_MYCSM 455 138 -
LYLVEGDSAGGSAKL P95681 426 142 -
LYLVEGDSAGGSAKL PARE_STAAU 426 142 -
LFIVEGDSAGGTAKM PARE_MYCGE 421 141 -
LYLVEGDSAGGSAKS GYRB_MYCCA 422 141 -
MYIVEGDSAGGSAKQ O84193 433 138 -
IFIVEGDSAGGSAKS GYBS_STRSH 465 138 -
VYIVEGDSAGGSAKK GYRB_TREPA 424 141 -
IFIVEGDSAGGSAKS GYRB_STRCO 467 138 -
LFIVEGDSAGGSAKQ GYRB_HALSQ 425 139 -
LFVVEGDSAGGTAKM PARE_MYCPN 424 141 -
IFLVEGDSAGGTAKS Q59526 422 141 -
IFIVEGDSAGGSAKA GYBR_STRSH 458 138 -
LILTEGDSAKSLAVS TP2B_CRILO 466 131 -
LILTEGDSAKSLAVS TP2B_HUMAN 478 131 -
LILTEGDSAKSLAVS TP2B_MOUSE 466 131 -
LILTEGDSAKSLAVS TP2B_CHICK 483 131 -
IFIVEGDSAGGCFSG GYRB_SYNY3 426 138 -
LILTEGDSAKTLAVS TP2A_CHICK 458 131 -
LFIVEGDSAGGSAKQ GYRB_BARBA 475 135 -
LFIVEGDSAGGSAKQ PARE_CAUCR 451 135 -
LILTEGDSAKTLAVS O55078 456 131 -
LILTEGDSAKTLAVS TP2A_RAT 455 131 -
LILTEGDSAKTLAVS TP2A_PIG 457 131 -
LILTEGDSAKTLAVS TP2A_MOUSE 456 131 -
LILTEGDSAKTLAVS TP2A_HUMAN 457 131 -
LILTEGDSAKTLAVS TP2A_CRIGR 456 131 -
LILTEGDSAKTLAVS O55079 456 131 -
LFIVEGDSAGGSAKM O68071 435 135 -
LFIVEGDSALGTAKL O69998 482 142 -
LILTEGDSAKSLAVS TOP2_DROME 437 130 -
LILTEGDSAKTLAVS TOP2_BOMMO 465 130 -
LILTEGDSAKALALA TOP2_CAEEL 493 132 -
LILTEGDSAKSLALA TOP2_ARATH 457 128 -
LFLVEGDSAGGSAKQ PARE_HAEIN 414 134 -
LFLVEGDSAGGSAKQ PARE_SALTY 414 134 -
LILTEGESAKGLAMA O59864 486 130 -
LFLVEGDSAGGSAKQ PARE_ECOLI 414 134 -
LIVTEGDSAKTLAIS O62199 485 127 -
LIITEGDSAKSLALA TP2M_DICDI 561 133 -
LILTEGLSAMNLAVA TOP2_CANAL 500 134 -
LVLTEGDSALSLAVA TOP2_YEAST 446 128 -
LILTEGDSAKTSCLA TOP2_PLAFK 495 134 -
LILTEGDSAKALAMA TOP2_PEA 444 128 -
LILTEGDSAKSLAVS O74336 501 129 -
LILTEGDSAKSLAVS TOP2_SCHPO 447 129 -
LILTEGDSAKALALA TP2M_CAEEL 493 132 -
LIVTEGDSAKALAQN TOP2_TRYBB 434 132 -
IFLTEGDSATGSMVS PARE_BORBU 399 134 -
LIVTEGDSAKALAQN TOP2_TRYCR 434 132 -
LIVTEGDSAKALALN TOP2_CRIFA 436 132 -
IFITEGESASASILA O84668 399 134 -
LILTEGDSAATLAIA O41065 410 125 -
LLAAEGDSALSLLRT TOP2_ASFB7 434 118 -
LLAAEGDSALSLVRA TOP2_ASFM2 433 117 -

Motif 6 width=17
Element Seqn Id St Int Rpt
KARYHKIIIMTDADVDG GYRB_BACS5 489 51 -
KLRYQKVIIMTDADVDG GYRB_SPICI 491 51 -
KLRYHKIILMTDADVDG GYRB_AQUAE 491 51 -
KARYHKVVIMTDADVDG GYRB_BACSU 490 51 -
KLRYHKIIIMTDADVDG GYRB_CLOAB 488 51 -
KLRYNKIIIMTDADVDG GYRB_MYCPN 503 51 -
KLRYGRIIIMTDADIDG P77993 489 51 -
KLRYHHIIIMTDADVDG GYRB_HAEIN 490 52 -
RLRYHKIIIMTDADVDG GYRB_HELPY 484 51 -
KLRYHSIIIMTDADVDG GYRB_SALTY 486 52 -
KLRYSKIVIMTDADVDG GYRB_MYCGE 503 51 -
KLRYHSIIIMTDADVDG GYRB_ECOLI 486 52 -
KLRYHNIIIMTDADVDG GYRB_PSEPU 489 52 -
KLRYHKIIIMADADVDG GYRB_BORBU 489 51 -
KIRYNKIIIMTDADVDG GYRB_MYCGA 499 51 -
KLKYHKIIIMTDADVDG GYRB_MYCHO 500 51 -
KLRYHKVIIMADADVDG GYRB_TREDE 491 51 -
KARYHKIVIMTDADVDG GYRB_STAAU 496 51 -
DINYDKIIIMTDADTDG PARE_BACSU 491 51 -
KLRYNHIIIMTDADVDG GYRB_BUCAP 487 52 -
KLRYHRIIIMTDADVDG GYRB_NEIGO 476 38 -
NVRYHRIIIMTDADVDG O86093 489 52 -
DANYDKIIIMTDADTDG PARE_STRPN 495 51 -
KLRYHKIVLMADADVDG GYRB_MYCTU 532 51 -
KARYQKLVLMTDADVDG Q59957 495 51 -
RLRYHKIVLMADADVDG GYRB_MYCLE 543 51 -
KARYQKLVLMTDADVDG GYRB_STRPN 495 51 -
KLRYHKIVLMADADVDG GYRB_MYCSM 521 51 -
DSNYNRVIIMTDADTDG P95681 492 51 -
DSNYNRVIIMTDADTDG PARE_STAAU 492 51 -
DLKYGKIIIMTDADNDG PARE_MYCGE 488 52 -
DINYGKIIIMTDADTDG GYRB_MYCCA 488 51 -
KLRYKRIIIMTDADVDG O84193 500 52 -
KLRYHKIILMADADVDG GYBS_STRSH 531 51 -
RIRYHKVIIMADADVDG GYRB_TREPA 490 51 -
KLRYHKIILMADADVDG GYRB_STRCO 533 51 -
KARYQRLILMTDADVDG GYRB_HALSQ 491 51 -
DRKYDKIIIMTDADNDG PARE_MYCPN 491 52 -
NLKYHKIIIMTDADTDG Q59526 488 51 -
KLRYHKIILMADADVDG GYBR_STRSH 524 51 -
TLRYGKIMIMTDQDQDG TP2B_CRILO 539 58 -
TLRYGKIMIMTDQDQDG TP2B_HUMAN 551 58 -
TLRYGKIMIMTDQDQDG TP2B_MOUSE 539 58 -
SLRYGKIMIMTDQDQDG TP2B_CHICK 556 58 -
SLRYHRVVIMTDADVDG GYRB_SYNY3 928 487 -
SLRYGKIMIMTDQDQDG TP2A_CHICK 531 58 -
DLRYERIIIMTDADVDG GYRB_BARBA 541 51 -
DLRYERIIIMTDADVDG PARE_CAUCR 517 51 -
TLRYGKIMIMTDQDQDG O55078 529 58 -
TLRYGKIMIMTDQDQDG TP2A_RAT 528 58 -
TLRYGKIMIMTDQDQDG TP2A_PIG 530 58 -
TLRYGKIMIMTDQDQDG TP2A_MOUSE 529 58 -
TLRYGKIMIMTDQDQDG TP2A_HUMAN 530 58 -
TLRYGKIMIMTDQDQDG TP2A_CRIGR 529 58 -
TLRYGKIMIMTDQDQDG O55079 529 58 -
DLRYDKIIIMTDADVDG O68071 501 51 -
AARYGKIIMMTDADVDG O69998 548 51 -
TLRYGKVMIMTDQDQDG TOP2_DROME 510 58 -
TLRYGKVMIMADQDQDG TOP2_BOMMO 538 58 -
SLRYGRLLILADQDEDG TOP2_CAEEL 564 56 -
SLRYGQMMIMTDQDHDG TOP2_ARATH 527 55 -
QLRYGKVCILADADSDG PARE_HAEIN 479 50 -
QLRYGKICILADADSDG PARE_SALTY 479 50 -
GLRYGHLMIMTDQDHDG O59864 556 55 -
QLRYGKICILADADSDG PARE_ECOLI 479 50 -
TLRYGKLMIMADQDQDG O62199 558 58 -
DLRYGRVMIMADQDHDG TP2M_DICDI 634 58 -
SLRYGHIMIMTDQDQDG TOP2_CANAL 572 57 -
SLRYGHLMIMTDQDHDG TOP2_YEAST 516 55 -
GLRYGSLMIMTDQDYDG TOP2_PLAFK 566 56 -
SLRYGHLMIMADQDHDG TOP2_PEA 514 55 -
GLRYGHLMIMTDQDHDG O74336 571 55 -
GLRYGHLMIMTDQDHDG TOP2_SCHPO 517 55 -
SLRYGRLLILADQDEDG TP2M_CAEEL 564 56 -
ELRYQRILIMTDQDADG TOP2_TRYBB 504 55 -
NLRYNKVVIATDADFDG PARE_BORBU 461 47 -
ELRYQRLLVMTDQDADG TOP2_TRYCR 504 55 -
ELRYQRLLVMTDQDADG TOP2_CRIFA 506 55 -
NLRYNQVILATDADVDG O84668 462 48 -
SLRYGHVMIMTDADVDG O41065 480 55 -
KLRYGCIVACVDQDLDG TOP2_ASFB7 528 79 -
KLRYGCIVACVDQDLDG TOP2_ASFM2 527 79 -

Motif 7 width=18
Element Seqn Id St Int Rpt
HIRTLILTFFYRYMRPLI GYRB_BACS5 507 1 -
HIRILLLTFFYRYMKDLI GYRB_SPICI 509 1 -
HIRTLLLTFFYRFMPKLV GYRB_AQUAE 509 1 -
HIRTLLLTFFYRYMRQII GYRB_BACSU 508 1 -
HIRTLILTFFYRYMTELI GYRB_CLOAB 506 1 -
HIRTLLLTFFFRFMYPLV GYRB_MYCPN 521 1 -
HIRTLLLTLFYRYMRPLI P77993 507 1 -
HIRTLLLTFFYRQMPELI GYRB_HAEIN 508 1 -
HIQTLLMTFFYRYLRPLI GYRB_HELPY 502 1 -
HIRTLLLTFFYRQMPEIV GYRB_SALTY 504 1 -
HIRTLLLTFFFRFMYPLV GYRB_MYCGE 521 1 -
HIRTLLLTFFYRQMPEIV GYRB_ECOLI 504 1 -
HIRTLLLTFFFRQLPELV GYRB_PSEPU 507 1 -
HIRTLLLAFFFRYMRDLI GYRB_BORBU 507 1 -
HIRILLLTFFFRHMFPLI GYRB_MYCGA 517 1 -
HITTLLLTFFYRYMKPLI GYRB_MYCHO 518 1 -
HIRTLLLTFFFRYMPQVI GYRB_TREDE 509 1 -
HIRTLLLTFFYRFMRPLI GYRB_STAAU 514 1 -
HIQVLLLTFFYRYMKPLI PARE_BACSU 509 1 -
HIRTLLLTFFYRQLPELI GYRB_BUCAP 505 1 -
HIRTLLLTFFYRQMPDLV GYRB_NEIGO 494 1 -
HIRTLLLTFFYRQMTELV O86093 507 1 -
HIQTLLLTFFYRYMRPLV PARE_STRPN 513 1 -
HISTLLLTLLFRFMRPLI GYRB_MYCTU 550 1 -
HIRTLLLTLIYRYMKPIL Q59957 513 1 -
HISTLLLTLLFRFMRPLI GYRB_MYCLE 561 1 -
HIRTLLLTLIYRYMKPIL GYRB_STRPN 513 1 -
HISTLLLTLLFRFMKPLV GYRB_MYCSM 539 1 -
HIQVLLLTFFFKYMKPLV P95681 510 1 -
HIQVLLLTFFFKYMKPLV PARE_STAAU 510 1 -
HIQILLLTFFYRYMQPLI PARE_MYCGE 506 1 -
HIQTLLLTFFYRHMKDLI GYRB_MYCCA 506 1 -
HIRTLLLTFFYRHMSALI O84193 518 1 -
HINTLLLTFLFRFMRPLV GYBS_STRSH 549 1 -
HIRTLLLTFFFRYLPQII GYRB_TREPA 508 1 -
HINTLLLTFLFRFMRPLV GYRB_STRCO 551 1 -
HIRTLLLTLLYRHMRPLI GYRB_HALSQ 509 1 -
HIQILLLTFFYRYMKPLI PARE_MYCPN 509 1 -
HIQVLLLTFFYRYMKELI Q59526 506 1 -
HISTLLLTFLFRFMRPLV GYBR_STRSH 542 1 -
HIKGLLINFIHHNWPSLL TP2B_CRILO 557 1 -
HIKGLLINFIHHNWPSLL TP2B_HUMAN 569 1 -
HIKGLLINFIHHNWPSLL TP2B_MOUSE 557 1 -
HIKGLLINFIHHNWPSLL TP2B_CHICK 574 1 -
HIRTLLLTFFYRYQRDLV GYRB_SYNY3 946 1 -
HIKGLLINFIHHNWPSLL TP2A_CHICK 549 1 -
HIASLLITFFFQEIPDLI GYRB_BARBA 559 1 -
HIASLLITFFYRTMPELI PARE_CAUCR 535 1 -
HIKGLLINFIHHNWPSLL O55078 547 1 -
HIKGLLINFIHHNWPSLL TP2A_RAT 546 1 -
HIKGLLINFIHHNWPSLL TP2A_PIG 548 1 -
HIKGLLINFIHHNWPSLL TP2A_MOUSE 547 1 -
HIKGLLINFIHHNWPSLL TP2A_HUMAN 548 1 -
HIKGLLINFIHHNWPSLL TP2A_CRIGR 547 1 -
HIKGLLINFIHHNWPSLL O55079 547 1 -
HIASLLMTFFFTQMRGLI O68071 519 1 -
HIRTLLLTLFHRYMRPMV O69998 566 1 -
HIKGLLINFIHTNWPELL TOP2_DROME 528 1 -
HIKGLIINFIHHNWPELL TOP2_BOMMO 556 1 -
HIKGLIVNFIHKFWPSLV TOP2_CAEEL 582 1 -
HIKGLLINFIHSFWPSLL TOP2_ARATH 545 1 -
HIATLLCALFLRHFPKLV PARE_HAEIN 497 1 -
HIATLLCALFVRHFRALV PARE_SALTY 497 1 -
HIKGLLINFLEAQFPSLL O59864 574 1 -
HIATLLCALFVKHFRALV PARE_ECOLI 497 1 -
HIKGLIISFLHHFWPSLI O62199 576 1 -
HIKGLVMNFIHYFWPNLL TP2M_DICDI 652 1 -
HIKGLIINFLETSFPGLL TOP2_CANAL 590 1 -
HIKGLIINFLESSFLGLL TOP2_YEAST 534 1 -
HIKGLLINMIHKFWPSLL TOP2_PLAFK 584 1 -
HIKGLLINFIHSFWPSLL TOP2_PEA 532 1 -
HIKGLIINYLESSYPSLL O74336 589 1 -
HIKGLIINYLESSYPSLL TOP2_SCHPO 535 1 -
HIKGLIVNFIHKFWPSLV TP2M_CAEEL 582 1 -
HIKGLVINAFESLWPSLL TOP2_TRYBB 522 1 -
HIRNLLLTFFLTFFEDLI PARE_BORBU 479 1 -
HIKGLVINAFEALWPSLL TOP2_TRYCR 522 1 -
HIKGLVINAFESLWPSLL TOP2_CRIFA 524 1 -
HIRNLMITFFLKTFLPLV O84668 480 1 -
HISGLVMNFFHSCFPSLL O41065 498 1 -
KILGLLLAYFHLFWPQLI TOP2_ASFB7 547 2 -
KILGLLLAYFHLFWPQLI TOP2_ASFM2 546 2 -

Motif 8 width=13
Element Seqn Id St Int Rpt
GYVYIAQPPLYKV GYRB_BACS5 527 2 -
GNIYIAQPPLYKV GYRB_SPICI 529 2 -
GYVYIAEPPLYRV GYRB_AQUAE 529 2 -
GYVYIAQPPLYKV GYRB_BACSU 528 2 -
GHVFIAQPPLYKV GYRB_CLOAB 526 2 -
GNIYIAQPPLYKV GYRB_MYCPN 541 2 -
GRVYIALPPLYRI P77993 527 2 -
GYVYIAQPPLYKV GYRB_HAEIN 528 2 -
GHVYIAQAPLYKY GYRB_HELPY 522 2 -
GHVYIAQPPLYKV GYRB_SALTY 524 2 -
GNIFIAQPPLYKV GYRB_MYCGE 541 2 -
GHVYIAQPPLYKV GYRB_ECOLI 524 2 -
GYIYIAQPPLYKV GYRB_PSEPU 527 2 -
GYIYIAMPPLYKI GYRB_BORBU 527 2 -
GHVYIAQPPLYRV GYRB_MYCGA 537 2 -
GFVYLAQPPLYKI GYRB_MYCHO 538 2 -
GHVYLAMPPLYKI GYRB_TREDE 529 2 -
GYVYIAQPPLYKL GYRB_STAAU 534 2 -
GKVFIALPPLYKV PARE_BACSU 529 2 -
GYVYIAQPPLYKV GYRB_BUCAP 525 2 -
GYIYIAQPPLYKA GYRB_NEIGO 514 2 -
GHIYIAQPPLYKV O86093 527 2 -
GHVYIALPPLYKM PARE_STRPN 533 2 -
GHVFLAQPPLYKL GYRB_MYCTU 570 2 -
GYVYIAQPPIYGV Q59957 533 2 -
GYVFLAQPPLYKL GYRB_MYCLE 581 2 -
GYVYIAQPPIYGV GYRB_STRPN 533 2 -
GHIFLAQPPLYKL GYRB_MYCSM 559 2 -
GRVFIALPPLYKL P95681 530 2 -
GRVFIALPPLYKL PARE_STAAU 530 2 -
GHVYLALPPLYKL PARE_MYCGE 526 2 -
KKVYIALPPLYKI GYRB_MYCCA 526 2 -
ECVYIAQPPLYRV O84193 538 2 -
GHVYLSRPPLYKI GYBS_STRSH 569 2 -
GYVYLAMPPLYRI GYRB_TREPA 528 2 -
GHVYLSRPPLYKI GYRB_STRCO 571 2 -
GYVYAAQPPLYRV GYRB_HALSQ 529 2 -
GHIYLALPPLYKF PARE_MYCPN 529 2 -
GKVYIALAPLYKI Q59526 526 2 -
GHVHLSRPPLYKI GYBR_STRSH 562 2 -
GFLEEFITPIVKA TP2B_CRILO 577 2 -
GFLEEFITPIVKA TP2B_HUMAN 589 2 -
GFLEEFITPIVKA TP2B_MOUSE 577 2 -
GFLEEFITPIVKA TP2B_CHICK 594 2 -
GYIYIACPPLYKL GYRB_SYNY3 966 2 -
NFLEEFITPIIKV TP2A_CHICK 569 2 -
GHLYLAVPPLYRI GYRB_BARBA 579 2 -
GHLFLALPPLYRL PARE_CAUCR 555 2 -
RFLEEFITPIVKV O55078 567 2 -
RFLEEFITPIVKV TP2A_RAT 566 2 -
RFLEEFITPIVKV TP2A_PIG 568 2 -
RFLEEFITPIVKV TP2A_MOUSE 567 2 -
RFLEEFITPIVKV TP2A_HUMAN 568 2 -
RFLEEFITPIVKV TP2A_CRIGR 567 2 -
RFLEEFITPIVKV O55079 567 2 -
GHLYLACPPLYRL O68071 539 2 -
GRVFAAVPPLHRI O69998 586 2 -
PFLEEFITPIVKA TOP2_DROME 548 2 -
PFLEEFITPIVKA TOP2_BOMMO 576 2 -
GFIQSFRTPLLKA TOP2_CAEEL 603 3 -
SFLVEFITPIVKA TOP2_ARATH 566 3 -
GHVYVAMPPLYRI PARE_HAEIN 517 2 -
GHVYVALPPLYRI PARE_SALTY 517 2 -
EFLIEFITPIVKV O59864 595 3 -
GHVYVALPPLYRI PARE_ECOLI 517 2 -
NFVEEFITPIVKA O62199 596 2 -
GFLVEFVTPIIKA TP2M_DICDI 672 2 -
GFLLEFITPIVKV TOP2_CANAL 611 3 -
GFLLEFITPIIKV TOP2_YEAST 555 3 -
GFLSEFVTPIVKV TOP2_PLAFK 605 3 -
SFLVEFTTPVIRA TOP2_PEA 553 3 -
GFLIQFITPIIKC O74336 610 3 -
GFLIQFITPIIKC TOP2_SCHPO 556 3 -
GFIQSFRTPLLKA TP2M_CAEEL 603 3 -
GFISIFSTPIVKA TOP2_TRYBB 544 4 -
GHMYILETPLFRV PARE_BORBU 499 2 -
GFISIFSTPIVKV TOP2_TRYCR 544 4 -
GYISLFSTPIVKI TOP2_CRIFA 546 4 -
NHLFILETPLFKV O84668 500 2 -
GFLKKFITPIVVA O41065 519 3 -
GFVKRLLTPLIRV TOP2_ASFB7 567 2 -
GFVKRLLTPLIRV TOP2_ASFM2 566 2 -

Motif 9 width=17
Element Seqn Id St Int Rpt
IQRYKGLGEMNPSQLWE GYRB_BACS5 569 29 -
IQRYKGLGEMNPEQLWE GYRB_SPICI 572 30 -
VQRYKGLGEMNPEQLWE GYRB_AQUAE 724 182 -
LQRYKGLGEMNATQLWE GYRB_BACSU 570 29 -
IQRYKGLGEMNPEQLWE GYRB_CLOAB 569 30 -
LQRYKGLGEMDAIQLWE GYRB_MYCPN 582 28 -
IQRYKGLGEMNPEQLWE P77993 568 28 -
VQRYKGLGEMNADQLWE GYRB_HAEIN 739 198 -
IQRYKGLGEMNPNDLWE GYRB_HELPY 705 170 -
IQRYKGLGEMNPEQLWE GYRB_SALTY 735 198 -
LQRYKGLGEMDALQLWE GYRB_MYCGE 582 28 -
IQRYKGLGEMNPEQLWE GYRB_ECOLI 735 198 -
IQRYKGLGEMNPDQLWE GYRB_PSEPU 738 198 -
LQRYKGLGEMNPTQLWE GYRB_BORBU 571 31 -
LQRYKGLGEMDDVQLWE GYRB_MYCGA 578 28 -
IQRYKGLGEMDPEQLWE GYRB_MYCHO 580 29 -
VQRYKGLGEMDGTQLWE GYRB_TREDE 571 29 -
IARYKGLGEMNADQLWE GYRB_STAAU 576 29 -
IQRYKGLGEMNADQLWE PARE_BACSU 573 31 -
VQRYKGLGEMNPDQLWN GYRB_BUCAP 735 197 -
IQRYKGLGEMNPEQLWE GYRB_NEIGO 714 187 -
IQRYKGLGEMNPEQLWE O86093 731 191 -
LQRYKGLGEMNADQLWE PARE_STRPN 577 31 -
IQRYKGLGEMDAKELWE GYRB_MYCTU 618 35 -
IQRYKGLGEMDDHQLWE Q59957 581 35 -
IQRYKGLGEMDAKELWE GYRB_MYCLE 629 35 -
IQRYKGLGEMDDHQLWE GYRB_STRPN 581 35 -
IQRYKGLGEMDAKELWE GYRB_MYCSM 607 35 -
LQRYKGLGEMNPEQLWE P95681 574 31 -
LQRYKGLGEMNPEQLWE PARE_STAAU 574 31 -
LQRYKGLGEMNADQLWD PARE_MYCGE 567 28 -
IQRYKGLGEMNADQLWQ GYRB_MYCCA 567 28 -
IQRYKGLGEMNADQLWD O84193 734 183 -
IQRFKGLGEMNAEELRI GYBS_STRSH 616 34 -
VQRYKGLGEMDGTQLWE GYRB_TREPA 570 29 -
VQRFKGLGEMNAEELRI GYRB_STRCO 618 34 -
VQRFKGLGEMNPDQLWD GYRB_HALSQ 571 29 -
VQRYKGLGEMNADQLWE PARE_MYCPN 569 27 -
VQRYKGLGEMNSEQLWT Q59526 567 28 -
IQRFKGLGEMNAEELRV GYBR_STRSH 609 34 -
IKYYKGLGTSTAKEAKE TP2B_CRILO 619 29 -
IKYYKGLGTSTAKEAKE TP2B_HUMAN 631 29 -
IKYYKGLGTSTAKEAKE TP2B_MOUSE 619 29 -
IKYYKGLGTSTAKEAKE TP2B_CHICK 636 29 -
IQRFKGLGEMMPQQLWD GYRB_SYNY3 1008 29 -
IKYYKGLGTSTSKEAKE TP2A_CHICK 611 29 -
IGRFKGLGEMRAEQLKE GYRB_BARBA 622 30 -
IGRFKGLGEMMASQLKE PARE_CAUCR 597 29 -
VKYYKGLGTSTSKEAKE O55078 609 29 -
VKYYKGLGTSTSKEAKE TP2A_RAT 608 29 -
VKYYKGLGTSTSKEAKE TP2A_PIG 610 29 -
VKYYKGLGTSTSKEAKE TP2A_MOUSE 609 29 -
VKYYKGLGTSTSKEAKE TP2A_HUMAN 610 29 -
VKYYKGLGTSTSKEAKE TP2A_CRIGR 609 29 -
VKYYKGLGTSTSKEAKE O55079 609 29 -
VQRFKGLGEMDAKDLKD O68071 582 30 -
IQRYKGLGEMDADQLAE O69998 637 38 -
IKYYKGLGTSTSKEAKE TOP2_DROME 590 29 -
IKYYKGLGTSTSKEAKE TOP2_BOMMO 618 29 -
IKYYKGLGTSTSNEARE TOP2_CAEEL 644 28 -
IKYYKGLGTSTAEEGKE TOP2_ARATH 611 32 -
VQRFKGLGEMNPSQLRE PARE_HAEIN 560 30 -
VQRFKGLGEMNPMQLRE PARE_SALTY 560 30 -
HKYYKGLGTSSTEEAQE O59864 642 34 -
VQRFKGLGEMNPMQLRE PARE_ECOLI 560 30 -
IKYYKGLGTSTAKEAKE O62199 638 29 -
IKYYKGLGTSTSAEAKE TP2M_DICDI 717 32 -
QKYYKGLGTSTPMEARE TOP2_CANAL 659 35 -
QKYYKGLGTSLAQEVRE TOP2_YEAST 600 32 -
IKYYKGLGTSTDREFKQ TOP2_PLAFK 646 28 -
IKYYKGLGTSTPQEGRE TOP2_PEA 597 31 -
IKYYKGLGTSDHDDMKS O74336 652 29 -
IKYYKGLGTSDHDDMKS TOP2_SCHPO 598 29 -
IKYYKGLGTSTSNEARE TP2M_CAEEL 644 28 -
CKYYKGLGTSTTAEGKE TOP2_TRYBB 586 29 -
VTRFKGLGEISPNEFKG PARE_BORBU 539 27 -
AKYYKALGTSTTAEGKE TOP2_TRYCR 586 29 -
AKYYKGLGTSTTAEGKE TOP2_CRIFA 590 31 -
ITRFKGLGEISPKEFKS O84668 543 30 -
IKYYKGLGTSSSTDAKH O41065 561 29 -
VKYYKGLAAHDTHEVKS TOP2_ASFB7 611 31 -
VKYYKGLAAHDTHEVKS TOP2_ASFM2 610 31 -