SPRINT Home UMBER Home Contents Standard Search Advanced Search Relation Search

==SPRINT==> PRINTS View



  selected as


PR00415

Identifier
ACONITASE  [View Relations]  [View Alignment]  
Accession
PR00415
No. of Motifs
9
Creation Date
13-DEC-1995  (UPDATE 07-JUN-1999)
Title
Aconitase family signature
Database References

PROSITE; PS00450 ACONITASE
PFAM; PF00330 aconitase; PF00694 Aconitase_C
INTERPRO; IPR001030
PDB; 5ACN
SCOP; 5ACN
CATH; 5ACN
Literature References
1. BEINERT, H. AND KENNEDY, M.C.
Engineering of protein bound iron-sulfur clusters. A tool for the study of 
protein and cluster chemistry and mechanism of iron-sulfur enzymes.
EUR.J.BIOCHEMISTRY 186 5-15 (1989).
 
2. LAUBLE, H., KENNEDY, M.C., BEINERT, H. AND STOUT, C.D.
Crystal structures of aconitase with trans-aconitate and nitrocitrate bound.
J.MOL.BIOL. 237 437-451 (1994).
 
3. ROBBINS, A.H. AND STOUT, C.D.
Structure of activated aconitase: formation of the [4Fe-4S] cluster in 
the crystal.
PROC.NATL.ACAD.SCI.U.S.A. 86 3639-3643 (1989).
 
4. HENTZE, M.W. AND ARGOS, P.
Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, 
and isopropylmalate isomerase.
NUCLEIC ACIDS RES. 19 1739-1740 (1991).
 
5. THEIL, E.C.
The IRE (iron regulatory element) family: structures which regulate mRNA 
translation or stability.
BIOFACTORS 4 87-93 (1993).
 
6. HAILE, D., ROUAULT, T.A., HARFORD, J.B., KENNEDY, M.C., BLONDIN, G.A.,
BEINERT, H. AND KLAUSNER, R.D.
Cellular regulation of the iron-responsive element binding protein:
disassembly of the cubane iron-sulfur cluster results in high-affinity
RNA binding.
PROC.NATL.ACAD.SCI.U.S.A. 89 11735-11739 (1992).
 
7. PHILPOTT, C.C., HAILE, D., ROUAULT, T.A. AND KLAUSNER, R.D.
Modification of a free Fe-S cluster cysteine residue in the active 
iron-responsive element-binding protein prevents RNA binding.
J.BIOL.CHEM. 268 17655-17658 (1993).

Documentation
Aconitase (aconitate hydratase) catalyses the stereo-specific isomerisation
of citrate to isocitrate via cis-aconitate in the tricarboxylic acid cycle,
a non-redox active process [1]. By contrast with the majority of iron-
sulphur proteins that function as electron carriers, the Fe-S cluster of
aconitase reacts directly with an enzyme substrate [1,2]. Aconitase has an
active [4Fe-4S](2+) cluster, which may convert to an inactive [3Fe-4S](1+) 
form. Three Cys residues have been shown to be ligands of the [4Fe-4S] 
centre [3]. The iron-responsive element binding protein (IRE-BP) and alpha-
isopropylmalate isomerase, an enzyme catalysing the second step in the
biosynthesis of leucine, are known aconitase homologues [4].
 
Iron regulatory elements (IREs) constitute a family of 28-nucleotide, non-
coding, stem-loop structures that regulate iron storage, haem synthesis
and iron uptake. They also participate in ribosome binding, and control
turnover (degradation). The specific regulator protein, the IRE-BP, binds
to IREs in both 5' and 3' regions [5], but only to RNA in the apo form,
without the Fe-S cluster. Expression of IRE-BP in cultured cells has
revealed that the protein functions either as an active aconitase, when 
cells are iron-replete, or as an active RNA-binding protein, when cells
are iron-depleted [6]. Mutant IRE-BPs, in which any or all of the 3 Cys
residues involved in Fe-S formation are replaced by Ser, have no aconitase
activity, but retain RNA-binding properties [7].
 
The 3D-structure of mitochondrial aconitase has been determined [2], and
has been shown to contain 4 alpha/beta domains: the 3 N-terminal domains
have similar folds, each with 3 alpha-beta-alpha layers; while the 
C-terminal domain forms a beta-barrel. 
 
ACONITASE is a 9-element fingerprint that provides a signature for the
aconitase family. The fingerprint was derived from an initial alignment of
18 sequences: the motifs were drawn from conserved regions spanning the N-
terminal half of the alignment - motif 8 includes the region encoded by
PROSITE pattern ACONITASE (PS00450), which contains the first conserved
Cys of the [4Fe-4S] cluster; and motif 9 includes the second and third 
conserved Cys residues. Two iterations on OWL26.3 were required to reach
convergence, at which point a true set comprising 32 sequences was
identified. Five partial matches were also found.
 
An update on SPTR37_9f identified a true set of 49 sequences, and 21
partial matches.
Summary Information
  49 codes involving  9 elements
3 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
1 codes involving 5 elements
3 codes involving 4 elements
4 codes involving 3 elements
10 codes involving 2 elements
Composite Feature Index
9494949494949494949
8213333333
7000000000
6000000000
5000111110
4003333000
3004314000
2004221128
123456789
True Positives
ACO1_ECOLI    ACOC_ARATH    ACOC_CAEEL    ACOC_CUCMA    
ACON_BOVIN ACON_BRAJA ACON_CAEEL ACON_GRAVE
ACON_HUMAN ACON_LEGPN ACON_PIG ACON_SCHPO
ACON_YEAST ACOX_YEAST IRE1_HUMAN IRE1_MOUSE
IRE1_RABIT IRE1_RAT IRE2_HUMAN IRE2_RAT
IREB_CHICK LEU2_ACTTI LEU2_BACSU LEU2_BUCAP
LEU2_CANMA LEU2_ECOLI LEU2_HAEIN LEU2_LACLA
LEU2_MYCLE LEU2_PHYBL LEU2_RHINI LEU2_RHIPU
LEU2_RHIRA LEU2_SALTY LEU2_SCHPO LEU2_USTMA
LEU2_YEAST O31293 O50579 O53166
O53237 O74699 O75809 O76934
O76935 O81396 O85065 O85072
O86534
True Positive Partials
Codes involving 8 elements
ACON_BACSU ACON_MYCAV LEU2_SYNY3
Codes involving 5 elements
LEU2_AZOVI
Codes involving 4 elements
LE21_METTH LE22_METTH O67656
Codes involving 3 elements
LE21_ARCFU LE22_ARCFU LE22_METJA O67078
Codes involving 2 elements
ACO2_ECOLI ACO2_HELPY ACO2_SYNY3 LE21_METJA
LYS4_EMENI LYS4_YEAST O53854 O59391
P72236 YBHJ_ECOLI
Sequence Titles
ACO1_ECOLI  ACONITATE HYDRATASE 1 (EC 4.2.1.3) (CITRATE HYDRO-LYASE 1) (ACONITASE 1) - ESCHERICHIA COLI. 
ACOC_ARATH ACONITATE HYDRATASE, CYTOPLASMIC (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
ACOC_CAEEL PROBABLE ACONITATE HYDRATASE, CYTOPLASMIC (EC 4.2.1.3) (CITRATE HYDRO- LYASE) (ACONITASE) - CAENORHABDITIS ELEGANS.
ACOC_CUCMA ACONITATE HYDRATASE, CYTOPLASMIC (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - CUCURBITA MAXIMA (PUMPKIN) (WINTER SQUASH).
ACON_BOVIN ACONITATE HYDRATASE, MITOCHONDRIAL PRECURSOR (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - BOS TAURUS (BOVINE).
ACON_BRAJA ACONITATE HYDRATASE (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - BRADYRHIZOBIUM JAPONICUM.
ACON_CAEEL PROBABLE ACONITATE HYDRATASE, MITOCHONDRIAL PRECURSOR (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - CAENORHABDITIS ELEGANS.
ACON_GRAVE ACONITATE HYDRATASE, MITOCHONDRIAL PRECURSOR (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - GRACILARIA VERRUCOSA.
ACON_HUMAN ACONITATE HYDRATASE, MITOCHONDRIAL PRECURSOR (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - HOMO SAPIENS (HUMAN).
ACON_LEGPN ACONITATE HYDRATASE (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) (MAJOR IRON-CONTAINING PROTEIN) (MICP) (IP210) - LEGIONELLA PNEUMOPHILA.
ACON_PIG ACONITATE HYDRATASE, MITOCHONDRIAL PRECURSOR (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - SUS SCROFA (PIG).
ACON_SCHPO ACONITATE HYDRATASE, MITOCHONDRIAL PRECURSOR (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
ACON_YEAST ACONITATE HYDRATASE, MITOCHONDRIAL PRECURSOR (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
ACOX_YEAST PUTATIVE ACONITASE IN PRP21-UBP12 INTERGENIC REGION (EC 4.2.1.3) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
IRE1_HUMAN IRON-RESPONSIVE ELEMENT BINDING PROTEIN 1 (IRE-BP 1) (IRON REGULATORY PROTEIN 1) (IRP1) (FERRITIN REPRESSOR PROTEIN) (ACONITATE HYDRATASE) (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - HOMO SAPIENS (HUMAN).
IRE1_MOUSE IRON-RESPONSIVE ELEMENT BINDING PROTEIN 1 (IRE-BP 1) (IRON REGULATORY PROTEIN 1) (IRP1) (FERRITIN REPRESSOR PROTEIN) (ACONITATE HYDRATASE) (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - MUS MUSCULUS (MOUSE).
IRE1_RABIT IRON-RESPONSIVE ELEMENT BINDING PROTEIN 1 (IRE-BP 1) (IRON REGULATORY PROTEIN 1) (IRP1) (FERRITIN REPRESSOR PROTEIN) (ACONITATE HYDRATASE) (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - ORYCTOLAGUS CUNICULUS (RABBIT).
IRE1_RAT IRON-RESPONSIVE ELEMENT BINDING PROTEIN 1 (IRE-BP 1) (IRON REGULATORY PROTEIN 1) (IRP1) (FERRITIN REPRESSOR PROTEIN) (ACONITATE HYDRATASE) (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - RATTUS NORVEGICUS (RAT).
IRE2_HUMAN IRON-RESPONSIVE ELEMENT BINDING PROTEIN 2 (IRE-BP 2) (IRON REGULATORY PROTEIN 2) (IRP2) - HOMO SAPIENS (HUMAN).
IRE2_RAT IRON-RESPONSIVE ELEMENT BINDING PROTEIN 2 (IRE-BP 2) (IRON REGULATORY PROTEIN 2) (IRP2) - RATTUS NORVEGICUS (RAT).
IREB_CHICK IRON-RESPONSIVE ELEMENT BINDING PROTEIN (IRE-BP) (IRON REGULATORY PROTEIN) (IRP) (FERRITIN REPRESSOR PROTEIN) (ACONITATE HYDRATASE) (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - GALLUS GALLUS (CHICKEN).
LEU2_ACTTI 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - ACTINOPLANES TEICHOMYCETICUS.
LEU2_BACSU 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) (SUPEROXIDE-INDUCIBLE PROTEIN 10) (SOI10) - BACILLUS SUBTILIS.
LEU2_BUCAP 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - BUCHNERA APHIDICOLA.
LEU2_CANMA 3-ISOPROPYLMALATE DEHYDRATASE (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - CANDIDA MALTOSA (YEAST).
LEU2_ECOLI 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - ESCHERICHIA COLI.
LEU2_HAEIN 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - HAEMOPHILUS INFLUENZAE.
LEU2_LACLA 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - LACTOCOCCUS LACTIS (SUBSP. LACTIS) (STREPTOCOCCUS LACTIS).
LEU2_MYCLE 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - MYCOBACTERIUM LEPRAE.
LEU2_PHYBL 3-ISOPROPYLMALATE DEHYDRATASE (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - PHYCOMYCES BLAKESLEEANUS.
LEU2_RHINI 3-ISOPROPYLMALATE DEHYDRATASE (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - RHIZOPUS NIVEUS.
LEU2_RHIPU 3-ISOPROPYLMALATE DEHYDRATASE (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - RHIZOMUCOR PUSILLUS.
LEU2_RHIRA 3-ISOPROPYLMALATE DEHYDRATASE (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - RHIZOMUCOR RACEMOSUS (MUCOR CIRCINELLOIDES F. LUSITANICUS).
LEU2_SALTY 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - SALMONELLA TYPHIMURIUM.
LEU2_SCHPO 3-ISOPROPYLMALATE DEHYDRATASE (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
LEU2_USTMA 3-ISOPROPYLMALATE DEHYDRATASE (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - USTILAGO MAYDIS (SMUT FUNGUS).
LEU2_YEAST 3-ISOPROPYLMALATE DEHYDRATASE (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
O31293 3-ISOPROPYLMALATE DEHYDRATASE SUBUNIT - BUCHNERA APHIDICOLA.
O50579 ACONITASE (EC 4.2.1.3) (ACONITATE HYDRATASE) (CITRATE HYDRO-LYASE) - XANTHOMONAS CAMPESTRIS.
O53166 ACONITATE HYDRATASE - MYCOBACTERIUM TUBERCULOSIS.
O53237 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT - MYCOBACTERIUM TUBERCULOSIS.
O74699 ACONITASE - ASPERGILLUS TERREUS.
O75809 ACONITATE HYDRATASE - HOMO SAPIENS (HUMAN).
O76934 IRON REGULATORY PROTEIN-1A - DROSOPHILA MELANOGASTER (FRUIT FLY).
O76935 IRON REGULATORY PROTEIN-1B - DROSOPHILA MELANOGASTER (FRUIT FLY).
O81396 ACONITASE-IRON REGULATED PROTEIN 1 - CITRUS LIMON (LEMON).
O85065 ISOPROPYLMALATE ISOMERASE SUBUNIT - BUCHNERA APHIDICOLA.
O85072 3-ISOPROPYLMALATE ISOMERASE SUBUNIT - BUCHNERA APHIDICOLA.
O86534 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT - STREPTOMYCES COELICOLOR.

ACON_BACSU ACONITATE HYDRATASE (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - BACILLUS SUBTILIS.
ACON_MYCAV ACONITATE HYDRATASE (EC 4.2.1.3) (CITRATE HYDRO-LYASE) (ACONITASE) - MYCOBACTERIUM AVIUM.
LEU2_SYNY3 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).

LEU2_AZOVI 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - AZOTOBACTER VINELANDII.

LE21_METTH PUTATIVE 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - METHANOBACTERIUM THERMOAUTOTROPHICUM.
LE22_METTH PUTATIVE 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - METHANOBACTERIUM THERMOAUTOTROPHICUM.
O67656 ACONITASE - AQUIFEX AEOLICUS.

LE21_ARCFU PUTATIVE 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - ARCHAEOGLOBUS FULGIDUS.
LE22_ARCFU PUTATIVE 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - ARCHAEOGLOBUS FULGIDUS.
LE22_METJA PUTATIVE 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - METHANOCOCCUS JANNASCHII.
O67078 LARGE SUBUNIT OF ISOPROPYLMALATE ISOMERASE - AQUIFEX AEOLICUS.

ACO2_ECOLI ACONITATE HYDRATASE 2 (EC 4.2.1.3) (CITRATE HYDRO-LYASE 2) (ACONITASE 2) - ESCHERICHIA COLI.
ACO2_HELPY ACONITATE HYDRATASE 2 (EC 4.2.1.3) (CITRATE HYDRO-LYASE 2) (ACONITASE 2) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
ACO2_SYNY3 ACONITATE HYDRATASE 2 (EC 4.2.1.3) (CITRATE HYDRO-LYASE 2) (ACONITASE 2) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
LE21_METJA PUTATIVE 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33) (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) - METHANOCOCCUS JANNASCHII.
LYS4_EMENI HOMOACONITASE PRECURSOR (EC 4.2.1.36) (HOMOACONITATE HYDRATASE) - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS).
LYS4_YEAST HOMOACONITASE PRECURSOR (EC 4.2.1.36) (HOMOACONITATE HYDRATASE) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
O53854 PUTATIVE MEMBRANE PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O59391 380AA LONG HYPOTHETICAL ISOMERASE - PYROCOCCUS HORIKOSHII.
P72236 MONOOXYGENASE SUBUNIT - PSEUDOMONAS SP.
YBHJ_ECOLI HYPOTHETICAL 81.5 KD PROTEIN IN MODC-BIOA INTERGENIC REGION - ESCHERICHIA COLI.
Scan History
OWL26_3    2  500  NSINGLE    
SPTR37_9f 2 500 NSINGLE
Initial Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
LRRAKDINQEVYNF ACON_BOVIN 113 113 -
LRRAKDINQEVYNF ACON_PIG 140 140 -
QCETLEQNIEAFGL LEU2_RHIRA 135 135 -
QCETLETNVKEFEL LEU2_PHYBL 76 76 -
QMQELIKNCKEFGV LEU2_ECOLI 81 81 -
QMQELIKNCNEFGV LEU2_SALTY 81 81 -
QVKTLENNVKQFGV LEU2_YEAST 95 95 -
TKIEIERNKERYEF ACON_LEGPN 148 148 -
VRLEMERNHERYVF ACO1_ECOLI 145 145 -
LARAKDLNKEVFNF ACON_CAEEL 148 148 -
MELEFQRNKERFAF CUCA 147 147 -
MAKAKSQNKEVYDF GVU17709 138 138 -
QDLEFERNKERFEF IREB_MOUSE 143 143 -
QDLEFERNRERFEF IREB_HUMAN 91 91 -
QDLEFERNRERFEF IREB_RABIT 143 143 -
LPSSIATNQEVFDF ACOX_YEAST 137 137 -
QIDTFTKNVKEFDV LEU2_LACLA 82 82 -
LKRAIDLNKEVYDF ACON_YEAST 136 136 -

Motif 2 width=9
Element Seqn Id St Int Rpt
VGFWRPGSG ACON_BOVIN 136 9 -
VGFWRPGSG ACON_PIG 163 9 -
MLVVPPGSG CUCA 171 10 -
LGFWKPGSG GVU17709 161 9 -
MRIIPPGSG IREB_MOUSE 167 10 -
MRIIPPGSG IREB_HUMAN 115 10 -
MRIIPPGSG IREB_RABIT 167 10 -
IQFWGPGSG ACOX_YEAST 160 9 -
VHMVAPESG LEU2_LACLA 108 12 -
VHTIGPEEG LEU2_YEAST 121 12 -
VHVMGPEQG LEU2_SALTY 107 12 -
VHVMGPEQG LEU2_ECOLI 107 12 -
VHVIGPEQG LEU2_PHYBL 102 12 -
VHVIGPEQG LEU2_RHIRA 161 12 -
VGFWKPGSG ACON_CAEEL 171 9 -
FSVVPPGTG ACO1_ECOLI 169 10 -
FQVVPPGTG ACON_LEGPN 172 10 -
MGFWKPGSG ACON_YEAST 159 9 -

Motif 3 width=14
Element Seqn Id St Int Rpt
LPGTTVVCGDSHTS LEU2_PHYBL 113 2 -
LPGMTIVCGDSHTA LEU2_ECOLI 118 2 -
LPGMTIVCGDSHTA LEU2_SALTY 118 2 -
LPGTTVVCGDSHTS LEU2_YEAST 132 2 -
AYPDTLVGTDSHTT ACON_LEGPN 205 24 -
LYPDSVVGTDSHTT CUCA 200 20 -
FPGLLMIGTDSHTP GVU17709 181 11 -
YYPDSLVGTDSHTT IREB_MOUSE 196 20 -
YYPDSLVGTDSHTT IREB_HUMAN 144 20 -
YYPDSLVGTDSHTT IREB_RABIT 196 20 -
APGLMMLGTDSHTP ACOX_YEAST 180 11 -
QPGKTIVCGDSHTA LEU2_LACLA 119 2 -
FPGALIIGTDSHTP ACON_YEAST 179 11 -
YPGVLLIGTDSHTP ACON_BOVIN 156 11 -
YPGVLLIGTDSHTP ACON_PIG 183 11 -
FPGLLLIGTDSHTP ACON_CAEEL 191 11 -
AYPDTLVGTDSHTT ACO1_ECOLI 202 24 -
LPATTVVCGDSHTS LEU2_RHIRA 172 2 -

Motif 4 width=16
Element Seqn Id St Int Rpt
THGAFGALAFGIGTSE LEU2_PHYBL 127 0 -
THGAFGALAFGIGTSE LEU2_ECOLI 132 0 -
THGAFGALAFGIGTSE LEU2_SALTY 132 0 -
THGAFGSLAFGIGTSE LEU2_YEAST 146 0 -
MINGLGVLGWGVGGIE ACON_LEGPN 219 0 -
MINGLGVLGWGVGGIE ACO1_ECOLI 216 0 -
NGGGLGGLCIGVGGAD ACON_CAEEL 205 0 -
NGGGLGGICIGVGGAD ACON_PIG 197 0 -
NGGGLGGICIGVGGAD ACON_BOVIN 170 0 -
NAGGLGQLAIGVGGAD ACON_YEAST 193 0 -
TNGAFGAIAFGIGTSE LEU2_LACLA 133 0 -
NAGGLGAIAIGVGGAD ACOX_YEAST 194 0 -
MIDGLGVLGWGVGGIE IREB_RABIT 210 0 -
MIDGLGILGWGVGGIE IREB_HUMAN 158 0 -
MIDGLGVLGWGVGGIE IREB_MOUSE 210 0 -
NAGGLGACAVGVGGAD GVU17709 195 0 -
MIDGLGVAGWGVGGIE CUCA 214 0 -
THGAFGALAFGIGTSE LEU2_RHIRA 186 0 -

Motif 5 width=14
Element Seqn Id St Int Rpt
GVVGKFVEFYGDGM CUCA 276 46 -
GGTGAIVEYFGEGV GVU17709 257 46 -
GVVGKFVEFFGPGV IREB_MOUSE 272 46 -
GVVGKFVEFFGPGV IREB_HUMAN 220 46 -
GVVGKFVEFFGLGV IREB_RABIT 272 46 -
GGTGCVIEFCGDTI LEU2_RHIRA 248 46 -
GGTRCVIEFCGSAI LEU2_PHYBL 189 46 -
GGTGHVVEFCGEAI LEU2_ECOLI 194 46 -
GGTGHVVEFCGDAI LEU2_SALTY 194 46 -
GGTGCVIEFAGEAI LEU2_YEAST 208 46 -
GVVGKFVEFYGPGL ACON_LEGPN 281 46 -
GVVGKFVEFYGDGL ACO1_ECOLI 278 46 -
GGTGAIVEYFGPGV ACON_CAEEL 267 46 -
GGTGAIVEYHGPGV ACON_PIG 259 46 -
GGTGAIVEYHGPGV ACON_BOVIN 232 46 -
GGTGKIVEYFGDGV ACON_YEAST 255 46 -
AGVGYAVEYSGDAI LEU2_LACLA 195 46 -
GGTGYIVEYFGEGV ACOX_YEAST 256 46 -

Motif 6 width=14
Element Seqn Id St Int Rpt
AQLSIADRATIANM IREB_HUMAN 234 0 -
AQLSIADRATIANM IREB_MOUSE 286 0 -
AALSMESRMSICNM LEU2_RHIRA 262 0 -
ASLSMEARMSICNM LEU2_PHYBL 203 0 -
RDLSMEGRMTLCNM LEU2_ECOLI 208 0 -
RALSMEGRMTLCNM LEU2_SALTY 208 0 -
EALSMEARMSMCNM LEU2_YEAST 222 0 -
NDLPLADRATISNM ACON_LEGPN 295 0 -
DSLPLADRATIANM ACO1_ECOLI 292 0 -
DSISATGMGTICNM ACON_CAEEL 281 0 -
DSISCTGMATICNM ACON_PIG 273 0 -
DSISCTGMATICNM ACON_BOVIN 246 0 -
DTFSATGMGTICNM ACON_YEAST 269 0 -
SDLSMEERMTICNM LEU2_LACLA 209 0 -
STLSCTGMATICNM ACOX_YEAST 270 0 -
DSLSCTGMGTICNM GVU17709 271 0 -
EELSLADRATIANM CUCA 290 0 -
AQLSIADRATIANM IREB_RABIT 286 0 -

Motif 7 width=15
Element Seqn Id St Int Rpt
PQVTWGTNPGQVISV LEU2_ECOLI 284 62 -
PCISGPKRPHDRVPL CUCA 372 68 -
PCCSGPKRPQDKVAV IREB_MOUSE 368 68 -
PCCSGPKRPQDKVAV IREB_HUMAN 316 68 -
PCCSGPKRPQDKVAV IREB_RABIT 368 68 -
PHINGPFTPDLAHPL GVU17709 345 60 -
PHVNGPFTPDLSTPI ACOX_YEAST 347 63 -
PMVTWGTNPGMGLEF LEU2_LACLA 284 61 -
PYINGPFTPDLATPV ACON_YEAST 344 61 -
PHINGPFTPDLAHPV ACON_BOVIN 320 60 -
PHINGPFTPDLAHPV ACON_PIG 347 60 -
PHVNGPFTPDLASSI ACON_CAEEL 355 60 -
ASLAGPKRPQDRVAL ACO1_ECOLI 371 65 -
PSLAGPKRPQDKVNL ACON_LEGPN 375 66 -
PTITWGTSPQDALPI LEU2_YEAST 302 66 -
PTLTWGTSPQDVVPI LEU2_RHIRA 339 63 -
PTITWGTSPQDVAPI LEU2_PHYBL 280 63 -
PQVTWGTNPGQVISV LEU2_SALTY 285 63 -

Motif 8 width=12
Element Seqn Id St Int Rpt
LIGSCTNSSYED ACON_CAEEL 389 19 -
FIGSCTNSRIED LEU2_RHIRA 396 42 -
FIGSCTNSRIED LEU2_PHYBL 337 42 -
FIGSCTNSRIED LEU2_ECOLI 341 42 -
FIGPCTNSRIED LEU2_SALTY 342 42 -
FIGSCTNGRIED LEU2_YEAST 359 42 -
AITSCTNTSNPS ACON_LEGPN 431 41 -
AITSCTNTSNPS ACO1_ECOLI 430 44 -
LIGSCTNSSYED ACON_PIG 381 19 -
LIGSCTNSSYED ACON_BOVIN 354 19 -
LIGSCTNSSYED ACON_YEAST 378 19 -
FIGSCTNARLGD LEU2_LACLA 335 36 -
LIGSCTNSSYQD ACOX_YEAST 381 19 -
AITSCTNTSNPS IREB_RABIT 433 50 -
AITSCTNTSNPS IREB_HUMAN 381 50 -
AITTCTNTSNPS IREB_MOUSE 433 50 -
LIGSCTNSSYED GVU17709 379 19 -
AITSCTNTSNPS CUCA 437 50 -

Motif 9 width=14
Element Seqn Id St Int Rpt
GGTVLANACGPCIG GVU17709 438 47 -
GAKVLANACGPCIG ACOX_YEAST 440 47 -
GFEWREPGCSACLG LEU2_LACLA 391 44 -
GGIVLANACGPCIG ACON_YEAST 437 47 -
GGIVLANACGPCIG ACON_BOVIN 413 47 -
GGIVLANACGPCIG ACON_PIG 440 47 -
GGMVLANACGPCIG ACON_CAEEL 448 47 -
GFNLVGYGCTTCIG ACO1_ECOLI 492 50 -
GFNLVGYGCTTCIG ACON_LEGPN 493 50 -
GFEWREAGCSMCLG LEU2_YEAST 416 45 -
GFHIVGYGCTTCIG CUCA 499 50 -
GFDWREAGCSMCLG LEU2_PHYBL 393 44 -
GFDWREAGCSMCLG LEU2_RHIRA 452 44 -
GFEWRLPGCSMCLA LEU2_ECOLI 397 44 -
GFDVVGYGCMTCIG IREB_RABIT 495 50 -
GFDVVGYGCMTCIG IREB_HUMAN 443 50 -
GFDVVGYGCMTCIG IREB_MOUSE 495 50 -
GFEWRLPGCSMCVA LEU2_SALTY 397 43 -
Final Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
QDLEFERNKERFEF IREB_CHICK 143 143 -
QDLEFERNRERFEF IRE1_RAT 143 143 -
QDLEFERNRERFEF IRE1_HUMAN 143 143 -
QDLEFERNRERFEF IRE1_RABIT 143 143 -
QCETLGENIEAFGL LEU2_RHINI 88 88 -
QCETLEQNIEAFGL LEU2_RHIRA 135 135 -
QVLALENNIKEFGL LEU2_SCHPO 94 94 -
QDLEFERNKERFEF IRE1_MOUSE 143 143 -
QCETLETNVKEFEL LEU2_PHYBL 76 76 -
QSLEFERNKERFTF O76935 147 147 -
QVQTLEQNVKDFDV LEU2_CANMA 89 89 -
QMQELIKNCKEFGV LEU2_ECOLI 81 81 -
MELEFQRNKERFAF ACOC_ARATH 147 147 -
QSIEFERNRERFNF ACOC_CAEEL 141 141 -
MELEFQRNKERFAF ACOC_CUCMA 147 147 -
QCMTLEENVKAFGL LEU2_USTMA 89 89 -
QCETLEHNVKEFGL LEU2_RHIPU 88 88 -
ESLEFQRNKERFTF O76934 149 149 -
QVLELDKNTKATGI LEU2_HAEIN 81 81 -
QMQELIKNCNEFGV LEU2_SALTY 81 81 -
QMQQLIKNCEEFNI O85065 82 82 -
QVKTLENNVKQFGV LEU2_YEAST 95 95 -
MEFEFQRNQERFAF O81396 147 147 -
QMQQLIRNCNQFNI LEU2_BUCAP 82 82 -
QVETLRRNCAEFGI O53237 89 89 -
QMQQLINNCKDFNI O31293 82 82 -
QMQQLIKNCKEFHI O85072 82 82 -
TKIEIERNKERYEF ACON_LEGPN 148 148 -
QEVEFGRNRERLQF IRE2_HUMAN 218 218 -
VRLEMERNHERYVF ACO1_ECOLI 145 145 -
QIETLRKNCAEFGV LEU2_ACTTI 102 102 -
QVETLRRNCAEFGV LEU2_MYCLE 92 92 -
QVTALERNCEEFGV LEU2_BACSU 82 82 -
QEVEFGRNRERLQF IRE2_RAT 219 219 -
LARAKDLNKEVFNF ACON_CAEEL 148 148 -
VEIEYQRNGERYQF O53166 144 144 -
LRRAKDINQEVYNF O75809 140 140 -
LRRAKDINQEVYNF ACON_HUMAN 140 140 -
LRRAKDINQEVYNF ACON_PIG 140 140 -
LRRAKDINQEVYNF ACON_BOVIN 113 113 -
QLETLRKNCADFGV O86534 82 82 -
VTEEYKQNQERYEF ACON_BRAJA 147 147 -
LKRAIDLNKEVYDF ACON_YEAST 136 136 -
LERANVTNKEVYDF ACON_SCHPO 136 136 -
QIDTFTKNVKEFDV LEU2_LACLA 82 82 -
MAKAKSQNKEVYDF ACON_GRAVE 138 138 -
LPSSIATNQEVFDF ACOX_YEAST 137 137 -
LARANEINKEVYDF O74699 137 137 -
GKIEFQRNQERYGF O50579 144 144 -

Motif 2 width=9
Element Seqn Id St Int Rpt
MRIIPPGSG IREB_CHICK 167 10 -
MRIIPPGSG IRE1_RAT 167 10 -
MRIIPPGSG IRE1_HUMAN 167 10 -
MRIIPPGSG IRE1_RABIT 167 10 -
VHVIGPEQG LEU2_RHINI 114 12 -
VHVIGPEQG LEU2_RHIRA 161 12 -
VHVIGPEQG LEU2_SCHPO 120 12 -
MRIIPPGSG IRE1_MOUSE 167 10 -
VHVIGPEQG LEU2_PHYBL 102 12 -
MLIVPPGSG O76935 171 10 -
VHVVGPEQG LEU2_CANMA 115 12 -
VHVMGPEQG LEU2_ECOLI 107 12 -
MLVVPPGSG ACOC_ARATH 171 10 -
LLIVPPGSG ACOC_CAEEL 165 10 -
MLVVPPGSG ACOC_CUCMA 171 10 -
VHIIGPEQG LEU2_USTMA 115 12 -
VHVIGPEQG LEU2_RHIPU 114 12 -
MLIVPPGSG O76934 173 10 -
VHVMGPEQG LEU2_HAEIN 107 12 -
VHVMGPEQG LEU2_SALTY 107 12 -
VHVIGPEQG O85065 108 12 -
VHTIGPEEG LEU2_YEAST 121 12 -
MPVVPPGSG O81396 171 10 -
VHVIGPEQG LEU2_BUCAP 108 12 -
VHVVGPQLG O53237 115 12 -
VHVMGPEQG O31293 108 12 -
VHVISPEQG O85072 108 12 -
FQVVPPGTG ACON_LEGPN 172 10 -
VAVIPPGTG IRE2_HUMAN 242 10 -
FSVVPPGTG ACO1_ECOLI 169 10 -
VHVIGPQLG LEU2_ACTTI 128 12 -
VHVVGPQLG LEU2_MYCLE 118 12 -
VHVVGPELG LEU2_BACSU 108 12 -
VAVIPPGTG IRE2_RAT 243 10 -
VGFWKPGSG ACON_CAEEL 171 9 -
FKVVPPGTG O53166 168 10 -
VGFWKPGSG O75809 163 9 -
VGFWSPGSG ACON_HUMAN 163 9 -
VGFWRPGSG ACON_PIG 163 9 -
VGFWRPGSG ACON_BOVIN 136 9 -
VHVVGPQLG O86534 108 12 -
FSVVPPGTG ACON_BRAJA 171 10 -
MGFWKPGSG ACON_YEAST 159 9 -
IGFWRPGSG ACON_SCHPO 159 9 -
VHMVAPESG LEU2_LACLA 108 12 -
LGFWKPGSG ACON_GRAVE 161 9 -
IQFWGPGSG ACOX_YEAST 160 9 -
IGFWKPGSG O74699 160 9 -
FKVVPPNTG O50579 168 10 -

Motif 3 width=14
Element Seqn Id St Int Rpt
YYPDSVVGTDSHTT IREB_CHICK 196 20 -
YYPDSLVGTDSHTT IRE1_RAT 196 20 -
YYPDSLVGTDSHTT IRE1_HUMAN 196 20 -
YYPDSLVGTDSHTT IRE1_RABIT 196 20 -
LPGTTVVCGDSHTS LEU2_RHINI 125 2 -
LPATTVVCGDSHTS LEU2_RHIRA 172 2 -
LPGTTLVCGDSHTS LEU2_SCHPO 131 2 -
YYPDSLVGTDSHTT IRE1_MOUSE 196 20 -
LPGTTVVCGDSHTS LEU2_PHYBL 113 2 -
LYPDSVVGTDSHTT O76935 205 25 -
LPGTTVVCGDSHTS LEU2_CANMA 126 2 -
LPGMTIVCGDSHTA LEU2_ECOLI 118 2 -
LYPDSVVGTDSHTT ACOC_ARATH 200 20 -
LYPDSVVGTDSHTT ACOC_CAEEL 195 21 -
LYPDSVVGTDSHTT ACOC_CUCMA 200 20 -
LPGATIVCGDSHTS LEU2_USTMA 126 2 -
LPGCTVNCGDSHTS LEU2_RHIPU 125 2 -
LYPDSVVGTDSHTT O76934 208 26 -
LPGMTIVCGDSHTA LEU2_HAEIN 118 2 -
LPGMTIVCGDSHTA LEU2_SALTY 118 2 -
LPGSTIVCGDSHTS O85065 119 2 -
LPGTTVVCGDSHTS LEU2_YEAST 132 2 -
LYPDSVGGTDSHTT O81396 200 20 -
LPGMTIVCGDSHTS LEU2_BUCAP 119 2 -
QPGMTIVCGDSHTS O53237 126 2 -
LPGMTIVCGDSHTS O31293 119 2 -
LPGMVIVCGDSHTS O85072 119 2 -
AYPDTLVGTDSHTT ACON_LEGPN 205 24 -
LFPDSVVGTDSHIT IRE2_HUMAN 271 20 -
AYPDTLVGTDSHTT ACO1_ECOLI 202 24 -
QPGMTIVCGDSHTA LEU2_ACTTI 139 2 -
QPGMTIVCGDSHTS LEU2_MYCLE 129 2 -
LPGKTIVCGDSHTS LEU2_BACSU 119 2 -
LFPDSVIGTDSHIT IRE2_RAT 272 20 -
FPGLLLIGTDSHTP ACON_CAEEL 191 11 -
AYPDTCVGTDSHTT O53166 197 20 -
YPGVLLIGTDSHTP O75809 183 11 -
YPGVLLIGTDSHTP ACON_HUMAN 183 11 -
YPGVLLIGTDSHTP ACON_PIG 183 11 -
YPGVLLIGTDSHTP ACON_BOVIN 156 11 -
QPGTTVVCGDSHTS O86534 119 2 -
AYPDSLVGTDSHTT ACON_BRAJA 212 32 -
FPGALIIGTDSHTP ACON_YEAST 179 11 -
FPGGLLIGTDSHTP ACON_SCHPO 179 11 -
QPGKTIVCGDSHTA LEU2_LACLA 119 2 -
FPGLLMIGTDSHTP ACON_GRAVE 181 11 -
APGLMMLGTDSHTP ACOX_YEAST 180 11 -
FPGGLMIGTDSHTP O74699 180 11 -
AYPDTVFGTDSHTT O50579 201 24 -

Motif 4 width=16
Element Seqn Id St Int Rpt
MVDGLGVLGWGVGGIE IREB_CHICK 210 0 -
MIDGLGVLGWGVGGIE IRE1_RAT 210 0 -
MIDGLGILGWGVGGIE IRE1_HUMAN 210 0 -
MIDGLGVLGWGVGGIE IRE1_RABIT 210 0 -
THGAFGALAFGIGTSE LEU2_RHINI 139 0 -
THGAFGALAFGIGTSE LEU2_RHIRA 186 0 -
THGAFGALAFGIGTSE LEU2_SCHPO 145 0 -
MIDGLGVLGWGVGGIE IRE1_MOUSE 210 0 -
THGAFGALAFGIGTSE LEU2_PHYBL 127 0 -
MINGLGVLGWGVGGIE O76935 219 0 -
THGAFGALAFGIGTSE LEU2_CANMA 140 0 -
THGAFGALAFGIGTSE LEU2_ECOLI 132 0 -
MIDGLGVAGWGVGGIE ACOC_ARATH 214 0 -
MIDGSGVLGWGVGGIE ACOC_CAEEL 209 0 -
MIDGLGVAGWGVGGIE ACOC_CUCMA 214 0 -
THGAFGALAFGIGTSE LEU2_USTMA 140 0 -
THGAFGALAFGIGTSE LEU2_RHIPU 139 0 -
MINGLGVLGWGVGGIE O76934 222 0 -
THGAFGALAFGIGTSE LEU2_HAEIN 132 0 -
THGAFGALAFGIGTSE LEU2_SALTY 132 0 -
THGAFGALSFGIGTSE O85065 133 0 -
THGAFGSLAFGIGTSE LEU2_YEAST 146 0 -
MIDGLGVAGWGVGGIE O81396 214 0 -
THGAFGALSFGIGTSE LEU2_BUCAP 133 0 -
THGAFGALAMGIGTSE O53237 140 0 -
THGAFGTLAFGIGTSE O31293 133 0 -
THGAFGALSFGIGTSE O85072 133 0 -
MINGLGVLGWGVGGIE ACON_LEGPN 219 0 -
MVNGLGILGWGVGGIE IRE2_HUMAN 285 0 -
MINGLGVLGWGVGGIE ACO1_ECOLI 216 0 -
THGASGALAFGIGTSE LEU2_ACTTI 153 0 -
THGAFGAIAMGIGTSE LEU2_MYCLE 143 0 -
THGAFGALAFGIGTSE LEU2_BACSU 133 0 -
MVNGLGILGWGVGGIE IRE2_RAT 286 0 -
NGGGLGGLCIGVGGAD ACON_CAEEL 205 0 -
MVNGLGVLGWGVGGIE O53166 211 0 -
NGGGLGGICIGVGGAD O75809 197 0 -
NGGGLGGICIGVGGAD ACON_HUMAN 197 0 -
NGGGLGGICIGVGGAD ACON_PIG 197 0 -
NGGGLGGICIGVGGAD ACON_BOVIN 170 0 -
THGAFGALAFGIGTSQ O86534 133 0 -
MVNGLAVLGWGVGGIE ACON_BRAJA 226 0 -
NAGGLGQLAIGVGGAD ACON_YEAST 193 0 -
NAGGLGMVAIGVGGAD ACON_SCHPO 193 0 -
TNGAFGAIAFGIGTSE LEU2_LACLA 133 0 -
NAGGLGACAVGVGGAD ACON_GRAVE 195 0 -
NAGGLGAIAIGVGGAD ACOX_YEAST 194 0 -
NAGGLAMAAIGVGGAD O74699 194 0 -
MINGIGVLGWGVGGIE O50579 215 0 -

Motif 5 width=14
Element Seqn Id St Int Rpt
GVVGKFVEFFGPGV IREB_CHICK 272 46 -
GVVGKFVEFFGPGV IRE1_RAT 272 46 -
GVVGKFVEFFGPGV IRE1_HUMAN 272 46 -
GVVGKFVEFFGLGV IRE1_RABIT 272 46 -
GGTGCVIEFCGEAN LEU2_RHINI 201 46 -
GGTGCVIEFCGDTI LEU2_RHIRA 248 46 -
GGTGSVIEFCGEAI LEU2_SCHPO 207 46 -
GVVGKFVEFFGPGV IRE1_MOUSE 272 46 -
GGTRCVIEFCGSAI LEU2_PHYBL 189 46 -
GVVGKFVEFYGPGV O76935 281 46 -
GGTGCVIEFAGKAI LEU2_CANMA 202 46 -
GGTGHVVEFCGEAI LEU2_ECOLI 194 46 -
GVVGKFVEFHGEGM ACOC_ARATH 276 46 -
GVVGKFVEFFGTGV ACOC_CAEEL 271 46 -
GVVGKFVEFYGDGM ACOC_CUCMA 276 46 -
GGTGHVIEYAGSTI LEU2_USTMA 202 46 -
GGTGCVIEFCGSAF LEU2_RHIPU 201 46 -
GVVGKFVEFYGPGV O76934 284 46 -
GGTGHVVEFCGEAI LEU2_HAEIN 194 46 -
GGTGHVVEFCGDAI LEU2_SALTY 194 46 -
SGSGYVIEFCGDVI O85065 195 46 -
GGTGCVIEFAGEAI LEU2_YEAST 208 46 -
GVVGKFVEFYGEGM O81396 276 46 -
GGSGYVIEFCGDVI LEU2_BUCAP 195 46 -
GGQGHVIEYRGSAI O53237 202 46 -
FGTGYVVEFSGETI O31293 195 46 -
AGTGYIIEFCGNVI O85072 195 46 -
GVVGKFVEFYGPGL ACON_LEGPN 281 46 -
GVAGKFVEFFGSGV IRE2_HUMAN 347 46 -
GVVGKFVEFYGDGL ACO1_ECOLI 278 46 -
GGNGHIVEYRGEAI LEU2_ACTTI 215 46 -
GGQGYVLEYRGSVI LEU2_MYCLE 205 46 -
FGTGYVIEYTGEVF LEU2_BACSU 195 46 -
GVAGKFVEFFGSGV IRE2_RAT 348 46 -
GGTGAIVEYFGPGV ACON_CAEEL 267 46 -
GVVGKFVEFYGEGV O53166 273 46 -
GGTGAIVEYHGPGV O75809 259 46 -
GGTGAIVEYHGPGV ACON_HUMAN 259 46 -
GGTGAIVEYHGPGV ACON_PIG 259 46 -
GGTGAIVEYHGPGV ACON_BOVIN 232 46 -
GGQGYILEYRGEAI O86534 195 46 -
GVVGKFVEFFGPGL ACON_BRAJA 288 46 -
GGTGKIVEYFGDGV ACON_YEAST 255 46 -
GGTGAIVEYFGPGV ACON_SCHPO 255 46 -
AGVGYAVEYSGDAI LEU2_LACLA 195 46 -
GGTGAIVEYFGEGV ACON_GRAVE 257 46 -
GGTGYIVEYFGEGV ACOX_YEAST 256 46 -
GGTGAIIEYHGPGV O74699 256 46 -
GVVGKFVEFYGEGL O50579 277 46 -

Motif 6 width=14
Element Seqn Id St Int Rpt
AQLSIADRATIANM IREB_CHICK 286 0 -
AQLSIADRATIANM IRE1_RAT 286 0 -
AQLSIADRATIANM IRE1_HUMAN 286 0 -
AQLSIADRATIANM IRE1_RABIT 286 0 -
ESLSMESRMSICNM LEU2_RHINI 215 0 -
AALSMESRMSICNM LEU2_RHIRA 262 0 -
EGLSMEARMSMCNM LEU2_SCHPO 221 0 -
AQLSIADRATIANM IRE1_MOUSE 286 0 -
ASLSMEARMSICNM LEU2_PHYBL 203 0 -
AELSIADRATISNM O76935 295 0 -
EDLSMEARMSICNM LEU2_CANMA 216 0 -
RDLSMEGRMTLCNM LEU2_ECOLI 208 0 -
RELSLADRATIANM ACOC_ARATH 290 0 -
ASLSIADRATIANM ACOC_CAEEL 285 0 -
EELSLADRATIANM ACOC_CUCMA 290 0 -
RSLSMEARMSICNM LEU2_USTMA 216 0 -
EQMSMEARMSVCNM LEU2_RHIPU 215 0 -
AELSIADRATISNM O76934 298 0 -
QDLSMEGRMTVCNM LEU2_HAEIN 208 0 -
RALSMEGRMTLCNM LEU2_SALTY 208 0 -
KKMNMEERMTICNM O85065 209 0 -
EALSMEARMSMCNM LEU2_YEAST 222 0 -
GQLPLADRATIANM O81396 290 0 -
KKMNMEERMTVCNM LEU2_BUCAP 209 0 -
ESLSMEGRMTICNM O53237 216 0 -
ENLTMEGRMTICNM O31293 209 0 -
KKMSMEERMTVCNM O85072 209 0 -
NDLPLADRATISNM ACON_LEGPN 295 0 -
SQLSIVDRTTIANM IRE2_HUMAN 361 0 -
DSLPLADRATIANM ACO1_ECOLI 292 0 -
RKLSMEGRMTICNM LEU2_ACTTI 229 0 -
ESMSMEGRMTICNM LEU2_MYCLE 219 0 -
RNMTMDERMTVCNM LEU2_BACSU 209 0 -
SQLSIVDRTTIANM IRE2_RAT 362 0 -
DSISATGMGTICNM ACON_CAEEL 281 0 -
AEVPLANRATLGNM O53166 287 0 -
DSISCTGMATICNM O75809 273 0 -
DSMSCTGMATICNM ACON_HUMAN 273 0 -
DSISCTGMATICNM ACON_PIG 273 0 -
DSISCTGMATICNM ACON_BOVIN 246 0 -
EKLSMEARMTICNM O86534 209 0 -
DHLSVADKATIANM ACON_BRAJA 302 0 -
DTFSATGMGTICNM ACON_YEAST 269 0 -
ESLSCTGMGTICNM ACON_SCHPO 269 0 -
SDLSMEERMTICNM LEU2_LACLA 209 0 -
DSLSCTGMGTICNM ACON_GRAVE 271 0 -
STLSCTGMATICNM ACOX_YEAST 270 0 -
NSLSCTGMGTICNM O74699 270 0 -
QHLPLADRATIGNM O50579 291 0 -

Motif 7 width=15
Element Seqn Id St Int Rpt
PCCSGPKRPQDKVAV IREB_CHICK 368 68 -
PCCSGPKRPQDKVAV IRE1_RAT 368 68 -
PCCSGPKRPQDKVAV IRE1_HUMAN 368 68 -
PCCSGPKRPQDKVAV IRE1_RABIT 368 68 -
PTVTWGTSPQDVAPI LEU2_RHINI 292 63 -
PTLTWGTSPQDVVPI LEU2_RHIRA 339 63 -
PTVTWGTSPQDVIPI LEU2_SCHPO 298 63 -
PCCSGPKRPQDKVAV IRE1_MOUSE 368 68 -
PTITWGTSPQDVAPI LEU2_PHYBL 280 63 -
TSVSGPKRPHDRVSV O76935 377 68 -
PTITWGNSPQDALPI LEU2_CANMA 293 63 -
PQVTWGTNPGQVISV LEU2_ECOLI 284 62 -
PCVSGPKRPHDRVPL ACOC_ARATH 372 68 -
PSVSGPKRPHDRVEL ACOC_CAEEL 367 68 -
PCISGPKRPHDRVPL ACOC_CUCMA 372 68 -
PTVTWGTSPQDVVAI LEU2_USTMA 294 64 -
PTLTWGTSPQDVVAI LEU2_RHIPU 292 63 -
TSVSGPKRPXDRVSV O76934 380 68 -
PQVTWGTNPGQVISV LEU2_HAEIN 285 63 -
PQVTWGTNPGQVISV LEU2_SALTY 285 63 -
PQVTWGTSPDQVLSI O85065 286 63 -
PTITWGTSPQDALPI LEU2_YEAST 302 66 -
PCISGPKRPHDRVPL O81396 372 68 -
PQITWGTSPDQVLSI LEU2_BUCAP 286 63 -
PFVTWGTNPGQGVPL O53237 293 63 -
PQITWGTNPSQTINI O31293 286 63 -
PQVTWGTNPDQVIGI O85072 286 63 -
PSLAGPKRPQDKVNL ACON_LEGPN 375 66 -
PSVSGPKRPQDRVAV IRE2_HUMAN 443 68 -
ASLAGPKRPQDRVAL ACO1_ECOLI 371 65 -
PFITWGTNPGQGAAL LEU2_ACTTI 306 63 -
PFVTWGTNPGQGVPL LEU2_MYCLE 296 63 -
PMVTWGINPGMVLPV LEU2_BACSU 286 63 -
ASVSGPKRPQDRVAV IRE2_RAT 443 67 -
PHVNGPFTPDLASSI ACON_CAEEL 355 60 -
PSIAGPKRPQDRIAL O53166 366 65 -
PHINGPFTPDLAHPV O75809 347 60 -
PHINGPFTPDLAHPV ACON_HUMAN 347 60 -
PHINGPFTPDLAHPV ACON_PIG 347 60 -
PHINGPFTPDLAHPV ACON_BOVIN 320 60 -
PFVTWGTNPGQGAPL O86534 286 63 -
PSMAGPKRPEGRIAL ACON_BRAJA 382 66 -
PYINGPFTPDLATPV ACON_YEAST 344 61 -
PHLNGPFTPDLATPI ACON_SCHPO 343 60 -
PMVTWGTNPGMGLEF LEU2_LACLA 284 61 -
PHINGPFTPDLAHPL ACON_GRAVE 345 60 -
PHVNGPFTPDLSTPI ACOX_YEAST 347 63 -
PHINGPFTPDLATPI O74699 344 60 -
PSLAGPKRPQDRVLL O50579 371 66 -

Motif 8 width=12
Element Seqn Id St Int Rpt
AITSCTNTSNPS IREB_CHICK 433 50 -
AITSCTNTSNPS IRE1_RAT 433 50 -
AITSCTNTSNPS IRE1_HUMAN 433 50 -
AITSCTNTSNPS IRE1_RABIT 433 50 -
FIGSCTNSRIED LEU2_RHINI 349 42 -
FIGSCTNSRIED LEU2_RHIRA 396 42 -
FIGSCTNSRIED LEU2_SCHPO 355 42 -
AITTCTNTSNPS IRE1_MOUSE 433 50 -
FIGSCTNSRIED LEU2_PHYBL 337 42 -
AITSCTNTSNPS O76935 443 51 -
FIGSCTNSRIED LEU2_CANMA 350 42 -
FIGSCTNSRIED LEU2_ECOLI 341 42 -
AITSCTNTSNPS ACOC_ARATH 437 50 -
AITSCTNTSNPS ACOC_CAEEL 432 50 -
AITSCTNTSNPS ACOC_CUCMA 437 50 -
FIGSCTNARIED LEU2_USTMA 351 42 -
FIGSCTNSRIED LEU2_RHIPU 349 42 -
AITSCTNTSNPS O76934 446 51 -
FIGSCTNSRIED LEU2_HAEIN 342 42 -
FIGPCTNSRIED LEU2_SALTY 342 42 -
FIGSCTNSRIED O85065 343 42 -
FIGSCTNGRIED LEU2_YEAST 359 42 -
AITSCTNTSNPS O81396 437 50 -
FIGSCTNSRIED LEU2_BUCAP 343 42 -
FVGSCTNGRIED O53237 350 42 -
FIGSCTNSRIED O31293 343 42 -
FIGSCTNSRIED O85072 343 42 -
AITSCTNTSNPS ACON_LEGPN 431 41 -
AVISCTNNCNPS IRE2_HUMAN 508 50 -
AITSCTNTSNPS ACO1_ECOLI 430 44 -
FVGSCTNGRLED LEU2_ACTTI 363 42 -
FVGSCTNGRIED LEU2_MYCLE 353 42 -
FIGSCTNSRMTD LEU2_BACSU 343 42 -
AVISCTNNCNPS IRE2_RAT 508 50 -
LIGSCTNSSYED ACON_CAEEL 389 19 -
AITSCTNTSNPE O53166 475 94 -
LIGSCTNSSYED O75809 381 19 -
LIGSCTNSSYED ACON_HUMAN 381 19 -
LIGSCTNSSYED ACON_PIG 381 19 -
LIGSCTNSSYED ACON_BOVIN 354 19 -
FVGSCTNGRIED O86534 343 42 -
AITSCTNTSNPS ACON_BRAJA 439 42 -
LIGSCTNSSYED ACON_YEAST 378 19 -
LIGSCTNSSYED ACON_SCHPO 377 19 -
FIGSCTNARLGD LEU2_LACLA 335 36 -
LIGSCTNSSYED ACON_GRAVE 379 19 -
LIGSCTNSSYQD ACOX_YEAST 381 19 -
LIGSCTNSSYED O74699 378 19 -
AITSCTNTSNPA O50579 454 68 -

Motif 9 width=14
Element Seqn Id St Int Rpt
GFDVVGYGCMTCIG IREB_CHICK 495 50 -
GFDVVGYGCMTCIG IRE1_RAT 495 50 -
GFDVVGYGCMTCIG IRE1_HUMAN 495 50 -
GFDVVGYGCMTCIG IRE1_RABIT 495 50 -
GFNWREAGCSMCLG LEU2_RHINI 405 44 -
GFDWREAGCSMCLG LEU2_RHIRA 452 44 -
GFDWREAGCSMCLG LEU2_SCHPO 412 45 -
GFDVVGYGCMTCIG IRE1_MOUSE 495 50 -
GFDWREAGCSMCLG LEU2_PHYBL 393 44 -
GFDIVGYGCMTCIG O76935 505 50 -
GFTWREAGCSMCLG LEU2_CANMA 407 45 -
GFEWRLPGCSMCLA LEU2_ECOLI 397 44 -
GFSIVGYGCTTCIG ACOC_ARATH 499 50 -
GFNIAGYGCMTCIG ACOC_CAEEL 494 50 -
GFHIVGYGCTTCIG ACOC_CUCMA 499 50 -
GFDWREAGCSMCLG LEU2_USTMA 407 44 -
GFDWREAGCSMCLG LEU2_RHIPU 405 44 -
GFDIVGYGCMTCIG O76934 508 50 -
GAEWRNPGCSMCLG LEU2_HAEIN 399 45 -
GFEWRLPGCSMCVA LEU2_SALTY 397 43 -
GFEWRLPGCSMCLG O85065 399 44 -
GFEWREAGCSMCLG LEU2_YEAST 416 45 -
GFHIVGYGCTTCIG O81396 499 50 -
GFEWRLPGCSMCLG LEU2_BUCAP 401 46 -
GAQWRQAGCSMCLG O53237 406 44 -
GFEWRLPGCSMCLA O31293 399 44 -
GFEWRLPGCSMCLG O85072 399 44 -
GFNLVGYGCTTCIG ACON_LEGPN 493 50 -
GFEIVGYGCSTCVG IRE2_HUMAN 570 50 -
GFNLVGYGCTTCIG ACO1_ECOLI 492 50 -
GAEWRFAGCSMCLG LEU2_ACTTI 419 44 -
GAQWRQPGCSMCLG LEU2_MYCLE 409 44 -
GFEWRESGCSMCLS LEU2_BACSU 399 44 -
GFEIVGYGCSTCVG IRE2_RAT 570 50 -
GGMVLANACGPCIG ACON_CAEEL 448 47 -
GFYLVGYGCTTCIG O53166 537 50 -
GGIVLANACGPCIG O75809 440 47 -
GGIVLANACGPCIG ACON_HUMAN 440 47 -
GGIVLANACGPCIG ACON_PIG 440 47 -
GGIVLANACGPCIG ACON_BOVIN 413 47 -
GAEWRHAGCSMCLG O86534 399 44 -
GFNLVGFGCTTCIG ACON_BRAJA 501 50 -
GGIVLANACGPCIG ACON_YEAST 437 47 -
GGIVLANACGPCIG ACON_SCHPO 436 47 -
GFEWREPGCSACLG LEU2_LACLA 391 44 -
GGTVLANACGPCIG ACON_GRAVE 438 47 -
GAKVLANACGPCIG ACOX_YEAST 440 47 -
GGVILANACGPCIG O74699 437 47 -
GFYVVGYGCTTCIG O50579 516 50 -