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PR00387

Identifier
PDIESTERASE1  [View Relations]  [View Alignment]  
Accession
PR00387
No. of Motifs
6
Creation Date
05-JUL-1995  (UPDATE 22-JUN-1999)
Title
3'5'-cyclic nucleotide phosphodiesterase signature
Database References

PROSITE; PS00126 PDEASE_I
PFAM; PF00233 PDEase
INTERPRO; IPR002073
Literature References
1. WATSON, S. AND ARKINSTALL, S.
G protein linked effector and second messenger systems.
IN THE G PROTEIN-LINKED RECEPTOR FACTSBOOK, ACADEMIC PRESS, 1994, PP.358-416.

Documentation
Retinal 3',5'-cGMP phosphodiesterase (PDE) is located in photoreceptor
outer segments [1]: it is light activated, playing a pivotal role in
signal transduction. In rod cells, PDE is oligomeric, comprising an
alpha-, a beta- and 2 gamma-subunits, while in cones, PDE is a homodimer
of alpha chains, which are associated with several smaller subunits.
Both rod and cone PDEs catalyse the hydrolysis of cAMP or cGMP to the
corresponding nucleoside 5' monophosphates, both enzymes also binding
cGMP with high affinity. The cGMP-binding sites are located in the
N-terminal half of the protein sequence, while the catalytic core 
resides in the C-terminal portion. 
 
PDIESTERASE1 is a 6-element fingerprint that provides a signature for
3',5'-cyclic nucleotide phosphodiesterases. The fingerprint was derived
from an initial alignment of 8 sequences: the motifs were drawn from
short conserved regions within the catalytic core in the C-terminal
half of the alignment. Three iterations on OWL26.0 were required to
reach convergence, at which point a true set comprising 51 sequences
was identified. Several partial matches were also found, largely
fragments and C-terminal truncations lacking one or more of the motifs.
 
An update on SPTR37_9f identified a true set of 50 sequences, and 16
partial matches.
Summary Information
  50 codes involving  6 elements
2 codes involving 5 elements
13 codes involving 4 elements
1 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
6505050505050
5112222
41301313013
3101100
2000000
123456
True Positives
CN1A_BOVIN    CN1A_HUMAN    CN1A_MOUSE    CN1B_BOVIN    
CN1B_HUMAN CN1B_MOUSE CN1B_RAT CN1C_HUMAN
CN1C_MOUSE CN1C_RAT CN2A_BOVIN CN2A_HUMAN
CN2A_RAT CN4A_HUMAN CN4A_RAT CN4B_HUMAN
CN4B_RAT CN4C_HUMAN CN4D_HUMAN CN4D_RAT
CN4Z_RAT CN5A_BOVIN CNA1_DROME CNRA_BOVIN
CNRA_CANFA CNRA_HUMAN CNRA_MOUSE CNRB_BOVIN
CNRB_CANFA CNRB_HUMAN CNRB_MOUSE CNRC_BOVIN
CNRC_CHICK CNRC_HUMAN O35470 O43433
O54735 O75026 O75522 O76074
O76092 O77746 O77747 Q28063
Q29470 Q62037 YBZJ_CAEEL YFGK_CAEEL
YNE6_CAEEL YST1_CAEEL
True Positive Partials
Codes involving 5 elements
O76104 O88502
Codes involving 4 elements
CN3A_HUMAN CN3A_RAT CN3B_HUMAN CN3B_RAT
CN7A_HUMAN CN7A_MOUSE CNA2_YEAST O60865
O70628 O75490 O75491 O76083
REGA_DICDI
Codes involving 3 elements
O45324
Sequence Titles
CN1A_BOVIN  CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1A (EC 3.1.4.17) (CAM-PDE 1A) (61 KD CAM-PDE) - BOS TAURUS (BOVINE). 
CN1A_HUMAN CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1A (EC 3.1.4.17) (CAM-PDE 1A) (61 KD CAM-PDE) (HCAM-1) - HOMO SAPIENS (HUMAN).
CN1A_MOUSE CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1A (EC 3.1.4.17) (CAM-PDE 1A) (61 KD CAM-PDE) - MUS MUSCULUS (MOUSE).
CN1B_BOVIN CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1B (EC 3.1.4.17) (CAM-PDE 1B) (63 KD CAM-PDE) - BOS TAURUS (BOVINE).
CN1B_HUMAN CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1B (EC 3.1.4.17) (CAM-PDE 1B) (63 KD CAM-PDE) - HOMO SAPIENS (HUMAN).
CN1B_MOUSE CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1B (EC 3.1.4.17) (CAM-PDE 1B) (63 KD CAM-PDE) - MUS MUSCULUS (MOUSE).
CN1B_RAT CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1B (EC 3.1.4.17) (CAM-PDE 1B) (63 KD CAM-PDE) - RATTUS NORVEGICUS (RAT).
CN1C_HUMAN CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1C (EC 3.1.4.17) (CAM-PDE 1C) (HCAM-3) - HOMO SAPIENS (HUMAN).
CN1C_MOUSE CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1C (EC 3.1.4.17) (CAM-PDE 1C) - MUS MUSCULUS (MOUSE).
CN1C_RAT CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1C (EC 3.1.4.17) (CAM-PDE 1C) - RATTUS NORVEGICUS (RAT).
CN2A_BOVIN CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) (CYCLIC GMP STIMULATED PHOSPHODIESTERASE) (CGS-PDE) - BOS TAURUS (BOVINE).
CN2A_HUMAN CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) (CYCLIC GMP STIMULATED PHOSPHODIESTERASE) (CGS-PDE) - HOMO SAPIENS (HUMAN).
CN2A_RAT CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) (CYCLIC GMP STIMULATED PHOSPHODIESTERASE) (CGS-PDE) - RATTUS NORVEGICUS (RAT).
CN4A_HUMAN CAMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE 4A (EC 3.1.4.17) (DPDE2) (PDE46) - HOMO SAPIENS (HUMAN).
CN4A_RAT CAMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE 4A, LARGE ISOFORMS (EC 3.1.4.17) (DPDE2) - RATTUS NORVEGICUS (RAT).
CN4B_HUMAN CAMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE 4B (EC 3.1.4.17) (DPDE4) (PDE32) - HOMO SAPIENS (HUMAN).
CN4B_RAT CAMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE 4B (EC 3.1.4.17) (DPDE4) - RATTUS NORVEGICUS (RAT).
CN4C_HUMAN CAMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE 4C (EC 3.1.4.17) (DPDE1) (PDE21) - HOMO SAPIENS (HUMAN).
CN4D_HUMAN CAMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE 4D (EC 3.1.4.17) (DPDE3) (PDE43) - HOMO SAPIENS (HUMAN).
CN4D_RAT CAMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE 4D (EC 3.1.4.17) (DPDE3) - RATTUS NORVEGICUS (RAT).
CN4Z_RAT CAMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE 4A, MEDIUM/SMALL ISOFORMS (EC 3.1.4.17) (DPDE2) (RNPDE4A1) - RATTUS NORVEGICUS (RAT).
CN5A_BOVIN CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) (CGB-PDE) (CGMP-BINDING CGMP-SPECIFIC PHOSPHODIESTERASE) - BOS TAURUS (BOVINE).
CNA1_DROME CAMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) (LEARNING/ MEMORY PROCESS PROTEIN) - DROSOPHILA MELANOGASTER (FRUIT FLY).
CNRA_BOVIN ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE ALPHA-SUBUNIT (EC 3.1.4.17) (GMP-PDE ALPHA) (PDE V-B1) - BOS TAURUS (BOVINE).
CNRA_CANFA ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE ALPHA-SUBUNIT (EC 3.1.4.17) (GMP-PDE ALPHA) - CANIS FAMILIARIS (DOG).
CNRA_HUMAN ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE ALPHA-SUBUNIT (EC 3.1.4.17) (GMP-PDE ALPHA) (PDE V-B1) - HOMO SAPIENS (HUMAN).
CNRA_MOUSE ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE ALPHA-SUBUNIT (EC 3.1.4.17) (GMP-PDE ALPHA) - MUS MUSCULUS (MOUSE).
CNRB_BOVIN ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE BETA-SUBUNIT (EC 3.1.4.17) (GMP-PDE BETA) - BOS TAURUS (BOVINE).
CNRB_CANFA ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE BETA-SUBUNIT (EC 3.1.4.17) (GMP-PDE BETA) - CANIS FAMILIARIS (DOG).
CNRB_HUMAN ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE BETA-SUBUNIT (EC 3.1.4.17) (GMP-PDE BETA) - HOMO SAPIENS (HUMAN).
CNRB_MOUSE ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE BETA-SUBUNIT (EC 3.1.4.17) (GMP-PDE BETA) - MUS MUSCULUS (MOUSE).
CNRC_BOVIN CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE ALPHA'-SUBUNIT (EC 3.1.4.17) (PDE V-C1) - BOS TAURUS (BOVINE).
CNRC_CHICK CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE ALPHA'-SUBUNIT (EC 3.1.4.17) - GALLUS GALLUS (CHICKEN).
CNRC_HUMAN CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE ALPHA'-SUBUNIT (EC 3.1.4.17) - HOMO SAPIENS (HUMAN).
O35470 CAMP-SPECIFIC PHOSPHODIESTERASE - RATTUS NORVEGICUS (RAT).
O43433 CAMP-SPECIFIC PHOSPHODIESTERASE PDE4D5 - HOMO SAPIENS (HUMAN).
O54735 CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) (CGB-PDE) (CGMP-BINDING CGMP-SPECIFIC PHOSPHODIESTERASE) - RATTUS NORVEGICUS (RAT).
O75026 CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) (CGB-PDE) (CGMP-BINDING CGMP-SPECIFIC PHOSPHODIESTERASE) - HOMO SAPIENS (HUMAN).
O75522 PUTATIVE NOVEL CAMP SPECIFIC PHOSPHODIESTERASE 4A VARIANT - HOMO SAPIENS (HUMAN).
O76074 CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) (CGB-PDE) (CGMP-BINDING CGMP-SPECIFIC PHOSPHODIESTERASE) - HOMO SAPIENS (HUMAN).
O76092 CYCLIC AMP SPECIFIC PHOSPHODIESTERASE RD1 - HOMO SAPIENS (HUMAN).
O77746 CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) (CGB-PDE) (CGMP-BINDING CGMP-SPECIFIC PHOSPHODIESTERASE) - CANIS FAMILIARIS (DOG).
O77747 CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) (CGB-PDE) (CGMP-BINDING CGMP-SPECIFIC PHOSPHODIESTERASE) - CANIS FAMILIARIS (DOG).
Q28063 3', 5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE - BOS TAURUS (BOVINE).
Q29470 CGMP-PHOSPHODIESTERASE ALPHA-SUBUNIT (EC 3.1.4.17) (3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE) - CANIS FAMILIARIS (DOG).
Q62037 ROD PHOSPHODIESTERASE BETA SUBUNIT ISOZYME - MUS MUSCULUS (MOUSE).
YBZJ_CAEEL PROBABLE 3',5'-CYCLIC PHOSPHODIESTERASE C32E12.2 (EC 3.1.4.17) - CAENORHABDITIS ELEGANS.
YFGK_CAEEL PROBABLE 3',5'-CYCLIC PHOSPHODIESTERASE T04D3.3 (EC 3.1.4.17) - CAENORHABDITIS ELEGANS.
YNE6_CAEEL PROBABLE 3',5'-CYCLIC PHOSPHODIESTERASE R08D7.6 (EC 3.1.4.17) - CAENORHABDITIS ELEGANS.
YST1_CAEEL PROBABLE 3',5'-CYCLIC PHOSPHODIESTERASE R153.1 (EC 3.1.4.17) - CAENORHABDITIS ELEGANS.

O76104 PDE4C-DELTA109 - HOMO SAPIENS (HUMAN).
O88502 CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 8A (EC 3.1.4.17) - MUS MUSCULUS (MOUSE).

CN3A_HUMAN CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE A (EC 3.1.4.17) (CYCLIC GMP INHIBITED PHOSPHODIESTERASE A) (CGI-PDE A) - HOMO SAPIENS (HUMAN).
CN3A_RAT CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE A (EC 3.1.4.17) (CYCLIC GMP INHIBITED PHOSPHODIESTERASE A) (CGI-PDE A) - RATTUS NORVEGICUS (RAT).
CN3B_HUMAN CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE B (EC 3.1.4.17) (CYCLIC GMP INHIBITED PHOSPHODIESTERASE B) (CGI-PDE B) (CGIPDE1) - HOMO SAPIENS (HUMAN).
CN3B_RAT CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE B (EC 3.1.4.17) (CYCLIC GMP INHIBITED PHOSPHODIESTERASE B) (CGI-PDE B) (CGIPDE1) - RATTUS NORVEGICUS (RAT).
CN7A_HUMAN HIGH-AFFINITY CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) (HCP1) - HOMO SAPIENS (HUMAN).
CN7A_MOUSE HIGH-AFFINITY CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) - MUS MUSCULUS (MOUSE).
CNA2_YEAST 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 2 (EC 3.1.4.17) (PDEASE 2) (HIGH-AFFINITY CAMP PHOSPHODIESTERASE) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
O60865 CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE A (EC 3.1.4.17) (CYCLIC GMP INHIBITED PHOSPHODIESTERASE A) (CGI-PDE A) - HOMO SAPIENS (HUMAN).
O70628 CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE TYPE 9 (EC 3.1.4.17) - MUS MUSCULUS (MOUSE).
O75490 CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE TYPE 9 (EC 3.1.4.17) - HOMO SAPIENS (HUMAN).
O75491 CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE TYPE 9 (EC 3.1.4.17) - HOMO SAPIENS (HUMAN).
O76083 CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE TYPE 9 (EC 3.1.4.17) - HOMO SAPIENS (HUMAN).
REGA_DICDI 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE REGA (EC 3.1.4.17) (PDEASE REGA) - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).

O45324 E01F3.1 PROTEIN - CAENORHABDITIS ELEGANS.
Scan History
OWL26_0    3  100  NSINGLE    
SPTR37_9f 1 100 NSINGLE
Initial Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
RAVTYHNWRHGFNV CNRC_BOVIN 552 552 -
RPVPYHNWSHAFAV YNE6_CAEEL 476 476 -
YKNPYHNLIHAADV CNCM_BOVIN 213 213 -
ADVAYHNSLHAADV CNA2_HUMAN 228 228 -
RRITYHNWRHGFNV CNRA_BOVIN 553 553 -
RKITYHNWRHGFNV CNRA_HUMAN 553 553 -
RRITYHNWRHGFNV CNRB_HUMAN 552 552 -
RRITYHNWRHGFNV CNRB_BOVIN 552 552 -

Motif 2 width=14
Element Seqn Id St Int Rpt
TDLEAFAMLAAAFC CNRC_BOVIN 583 17 -
TDLEAFAMVTAGLC CNRB_BOVIN 583 17 -
TDLEALAMVTAAFC CNRA_BOVIN 584 17 -
TELEILAMVFAAAI CNCM_BOVIN 244 17 -
TDLEAFAMVTAGLC CNRB_HUMAN 583 17 -
TDLEILAALFAAAI CNA2_HUMAN 259 17 -
TDLEALAMVTAAFC CNRA_HUMAN 584 17 -
SDMERLSLLIACLC YNE6_CAEEL 507 17 -

Motif 3 width=16
Element Seqn Id St Int Rpt
HDIDHRGTNNLYQMKS CNRA_BOVIN 598 0 -
HDVDHPGVSNQFLINT CNA2_HUMAN 273 0 -
HDYEHTGTTNNFHIQT CNCM_BOVIN 258 0 -
HDIDHRGTNNLYQMKS CNRA_HUMAN 598 0 -
HDIDHRGTNNLYQMKS CNRB_HUMAN 597 0 -
HDIDHRGTNNLYQMKS CNRB_BOVIN 597 0 -
HDIDHRGTNNLYQMKS CNRC_BOVIN 597 0 -
HDIDHRGTTNSFQMQS YNE6_CAEEL 521 0 -

Motif 4 width=17
Element Seqn Id St Int Rpt
SVLENHHLAVGFKLLQE CNA2_HUMAN 300 11 -
SILERHHLEFGKTLLRD CNRA_BOVIN 624 10 -
SILERHHLEFGKTLLRD CNRA_HUMAN 624 10 -
SILERHHLEFGKFLLSE CNRB_HUMAN 623 10 -
SILERHHLEFGKFLLSE CNRB_BOVIN 623 10 -
SILERHHLEYSKTLLQD CNRC_BOVIN 623 10 -
SVLERHHFAQTIKLLQQ YNE6_CAEEL 551 14 -
SVLENHHVSAAYRLMQE CNCM_BOVIN 285 11 -

Motif 5 width=14
Element Seqn Id St Int Rpt
MTACDLSAITKPWE CNRC_BOVIN 714 74 -
LHAADISHPAKSWK CNCM_BOVIN 361 59 -
VHCADLSNPTKPLE CNA2_HUMAN 387 70 -
MTACDLSAITKPWE CNRA_BOVIN 715 74 -
MTACDLSAITKPWE CNRA_HUMAN 715 74 -
MTACDLSAITKPWE CNRB_HUMAN 714 74 -
MTASDLSDQAKNFH YNE6_CAEEL 631 63 -
MTACDLSAITKPWE CNRB_BOVIN 714 74 -

Motif 6 width=17
Element Seqn Id St Int Rpt
KVALLVAAEFWEQGDLE CNRA_BOVIN 732 3 -
QWTDRIMAEFFQQGDRE CNA2_HUMAN 404 3 -
QVALLVAAEFWEQGDLE CNRA_HUMAN 732 3 -
KVALLVAAEFWEQGDLE CNRB_HUMAN 731 3 -
KVALLVAAEFWEQGDLE CNRB_BOVIN 731 3 -
QVALLVANEFWEQGDLE CNRC_BOVIN 731 3 -
RIAENIYLEFFAQGDLE YNE6_CAEEL 648 3 -
RWTMALMEEFFLQGDKE CNCM_BOVIN 378 3 -
Final Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
ADVAYHNSLHAADV CN4A_HUMAN 428 428 -
ADVAYHNSLHAADV CN4A_RAT 414 414 -
ADVAYHNSLHAADV CN4Z_RAT 180 180 -
ADVAYHNSLHAADV O75522 402 402 -
ADVAYHNSLHAADV O76092 189 189 -
SDVAYHNSLHAADV CN4B_HUMAN 401 401 -
SDVAYHNSLHAADV CN4B_RAT 386 386 -
ADVAYHNNIHAADV CN4D_HUMAN 337 337 -
ADVAYHNNIHAADV CN4D_RAT 321 321 -
ADVAYHNNIHAADV O35470 452 452 -
ADVAYHNNIHAADV O43433 393 393 -
ANVAYHNSLHAADV CN4C_HUMAN 383 383 -
RRITYHNWRHGFNV CNRA_BOVIN 553 553 -
RRITYHNWRHGFNV CNRA_CANFA 553 553 -
RRITYHNWRHGFNV CNRA_MOUSE 553 553 -
RRITYHNWRHGFNV Q29470 554 554 -
RKITYHNWRHGFNV CNRA_HUMAN 553 553 -
RRITYHNWRHGFNV CNRB_HUMAN 552 552 -
RRITYHNWRHGFNV CNRB_CANFA 552 552 -
RRITYHNWRHGFNV CNRB_BOVIN 552 552 -
RRITYHNWRHGFNV CNRB_MOUSE 552 552 -
RRITYHNWRHGFNV Q62037 552 552 -
RAVTYHNWRHGFNV CNRC_BOVIN 552 552 -
RDITYHNWRHGFNV CNRC_CHICK 557 557 -
KDNPFHNSLHAADV CNA1_DROME 242 242 -
RAVTYHNWQHGFNV CNRC_HUMAN 557 557 -
YKNPYHNLIHAADV CN1A_BOVIN 213 213 -
YKNPYHNLIHAADV Q28063 198 198 -
YKNPYHNLIHAADV CN1A_HUMAN 213 213 -
RNNHYHNFIHAADV YST1_CAEEL 277 277 -
KNVAYHNWRHAFNT O77747 566 566 -
KNVAYHNWRHAFNT O77746 598 598 -
KNVAYHNWRHAFNT O76074 608 608 -
KNVAYHNWRHAFNT O75026 598 598 -
KNVAYHNWRHAFNT CN5A_BOVIN 598 598 -
YKNPYHNQIHAADV CN1B_BOVIN 216 216 -
YKNPYHNQIHAADV CN1B_MOUSE 217 217 -
YKNPYHNQIHAADV CN1B_RAT 217 217 -
HKNPYHNLVHAADV CN1A_MOUSE 234 234 -
YKNPYHNQIHAADV CN1B_HUMAN 218 218 -
KNVAYHNWRHAFNT O54735 566 566 -
RPVPYHNWSHAFAV YNE6_CAEEL 476 476 -
HKNPYHNLMHAADV CN1C_RAT 283 283 -
HKNPYHNLMHAADV CN1C_MOUSE 223 223 -
RDPPYHNWMHAFSV CN2A_RAT 639 639 -
RDPPYHNWMHAFSV CN2A_HUMAN 651 651 -
RDPPYHNWMHAFSV CN2A_BOVIN 631 631 -
HKNPYHNLMHAADV CN1C_HUMAN 223 223 -
HNNPYHNVVHAADV YFGK_CAEEL 328 328 -
RRVAYHNWAHGWSV YBZJ_CAEEL 185 185 -

Motif 2 width=14
Element Seqn Id St Int Rpt
TDLEILAALFAAAI CN4A_HUMAN 459 17 -
TDLEILAALFAAAI CN4A_RAT 445 17 -
TDLEILAALFAAAI CN4Z_RAT 211 17 -
TDLEILAALFAAAI O75522 433 17 -
TDLEILAALFAAAI O76092 220 17 -
TDLEILAAIFAAAI CN4B_HUMAN 432 17 -
TDLEILAAIFAAAI CN4B_RAT 417 17 -
TDLEILAAIFASAI CN4D_HUMAN 368 17 -
TDLEILAAIFASAI CN4D_RAT 352 17 -
TDLEILAAIFASAI O35470 483 17 -
TDLEILAAIFASAI O43433 424 17 -
TDLEILAALFASAI CN4C_HUMAN 414 17 -
TDLEALAMVTAAFC CNRA_BOVIN 584 17 -
TDLEALAMVTAAFC CNRA_CANFA 584 17 -
TDLEALAMVTAAFC CNRA_MOUSE 584 17 -
TDLEALAMVTAAFC Q29470 585 17 -
TDLEALAMVTAAFC CNRA_HUMAN 584 17 -
TDLEAFAMVTAGLC CNRB_HUMAN 583 17 -
TDLEAFAMVTAGLC CNRB_CANFA 583 17 -
TDLEAFAMVTAGLC CNRB_BOVIN 583 17 -
TDLEAFAMVTAGLC CNRB_MOUSE 583 17 -
TDLEAFAMVTAGLC Q62037 583 17 -
TDLEAFAMLAAAFC CNRC_BOVIN 583 17 -
TDLEAFAMVAAAFC CNRC_CHICK 588 17 -
TPLEVGGALFAACI CNA1_DROME 273 17 -
TDLEAFAMLAAAFC CNRC_HUMAN 588 17 -
TELEILAMVFAAAI CN1A_BOVIN 244 17 -
TELEILAMVFAAAI Q28063 229 17 -
TELEILAMVFAAAI CN1A_HUMAN 244 17 -
TDLEVLAAIFAGAV YST1_CAEEL 308 17 -
TDLEILALLIAALS O77747 597 17 -
TDLEILALLIAALS O77746 629 17 -
TDLEILALLIAALS O76074 639 17 -
TDLEILALLIAALS O75026 629 17 -
TDLEILALLIAALS CN5A_BOVIN 629 17 -
SEIEVLAIIFAAAI CN1B_BOVIN 247 17 -
SEIEVLAIIFAAAI CN1B_MOUSE 248 17 -
SEIEVLAIIFAAAI CN1B_RAT 248 17 -
TELEILAMVFAAAI CN1A_MOUSE 265 17 -
SEIELLAIIFAAAI CN1B_HUMAN 249 17 -
TDLETLALLIAALS O54735 597 17 -
SDMERLSLLIACLC YNE6_CAEEL 507 17 -
TELEIFAIIFSAAI CN1C_RAT 314 17 -
TELEIFAIIFSAAI CN1C_MOUSE 254 17 -
EDIEIFALFISCMC CN2A_RAT 670 17 -
EDIEIFALFISCMC CN2A_HUMAN 682 17 -
EDMEIFALFISCMC CN2A_BOVIN 662 17 -
TELEIFAIIFSAAI CN1C_HUMAN 254 17 -
GDLELLAVLFGALI YFGK_CAEEL 359 17 -
TKLEALALYVSCLC YBZJ_CAEEL 214 15 -

Motif 3 width=16
Element Seqn Id St Int Rpt
HDVDHPGVSNQFLINT CN4A_HUMAN 473 0 -
HDVDHPGVSNQFLINT CN4A_RAT 459 0 -
HDVDHPGVSNQFLINT CN4Z_RAT 225 0 -
HDVDHPGVSNQFLINT O75522 447 0 -
HDVDHPGVSNQFLINT O76092 234 0 -
HDVDHPGVSNQFLINT CN4B_HUMAN 446 0 -
HDVDHPGVSNQFLINT CN4B_RAT 431 0 -
HDVDHPGVSNQFLINT CN4D_HUMAN 382 0 -
HDVDHPGVSNQFLINT CN4D_RAT 366 0 -
HDVDHPGVSNQFLINT O35470 497 0 -
HDVDHPGVSNQFLINT O43433 438 0 -
HDVDHPGVSNQFLINT CN4C_HUMAN 428 0 -
HDIDHRGTNNLYQMKS CNRA_BOVIN 598 0 -
HDIDHRGTNNLYQMKS CNRA_CANFA 598 0 -
HDIDHRGTNNLYQMKS CNRA_MOUSE 598 0 -
HDIDHRGTNNLYQMKS Q29470 599 0 -
HDIDHRGTNNLYQMKS CNRA_HUMAN 598 0 -
HDIDHRGTNNLYQMKS CNRB_HUMAN 597 0 -
HDIDHRGTNNLYQMKS CNRB_CANFA 597 0 -
HDIDHRGTNNLYQMKS CNRB_BOVIN 597 0 -
HDIDHRGTNNLYQMKS CNRB_MOUSE 597 0 -
HDIDHRGTNNLYQMKS Q62037 597 0 -
HDIDHRGTNNLYQMKS CNRC_BOVIN 597 0 -
HDIDHRGTNNLYQMKS CNRC_CHICK 602 0 -
HDVDHPGLTNQFLVNS CNA1_DROME 287 0 -
HDIDHRGTNNLYQMKS CNRC_HUMAN 602 0 -
HDYEHTGTTNNFHIQT CN1A_BOVIN 258 0 -
HDYEHTGTTNNFHIQT Q28063 243 0 -
HDYEHTGTTNNFHIQT CN1A_HUMAN 258 0 -
HDVDHPGFTNQYLINS YST1_CAEEL 322 0 -
HDLDHRGVNNSYIQRS O77747 611 0 -
HDLDHRGVNNSYIQRS O77746 643 0 -
HDLDHRGVNNSYIQRS O76074 653 0 -
HDLDHRGVNNSYIQRS O75026 643 0 -
HDLDHRGVNNSYIQRS CN5A_BOVIN 643 0 -
HDYEHTGTTNSFHIQT CN1B_BOVIN 261 0 -
HDYEHTGTTNSFHIQT CN1B_MOUSE 262 0 -
HDYEHTGTTNSFHIQT CN1B_RAT 262 0 -
HDYEHTGTTNNFHIQT CN1A_MOUSE 279 0 -
HDYEHTGTTNSFHIQT CN1B_HUMAN 263 0 -
HDLDHRGVNNSYIQRS O54735 611 0 -
HDIDHRGTTNSFQMQS YNE6_CAEEL 521 0 -
HDYEHTGTTNNFHIQT CN1C_RAT 328 0 -
HDYEHTGTTNNFHIQT CN1C_MOUSE 268 0 -
HDLDHRGTNNSFQVAS CN2A_RAT 684 0 -
HDLDHRGTNNSFQVAS CN2A_HUMAN 696 0 -
HDLDHRGTNNSFQVAS CN2A_BOVIN 676 0 -
HDYEHTGTTNNFHIQT CN1C_HUMAN 268 0 -
HDYEHTGHTNNFHIQS YFGK_CAEEL 373 0 -
HDLDHRGKNNAYMKTM YBZJ_CAEEL 228 0 -

Motif 4 width=17
Element Seqn Id St Int Rpt
SVLENHHLAVGFKLLQE CN4A_HUMAN 500 11 -
SVLENHHLAVGFKLLQE CN4A_RAT 486 11 -
SVLENHHLAVGFKLLQE CN4Z_RAT 252 11 -
SVLENHHLAVGFKLLQE O75522 474 11 -
SVLENHHLAVGFKLLQE O76092 261 11 -
SVLENHHLAVGFKLLQE CN4B_HUMAN 473 11 -
SVLENHHLAVGFKLLQE CN4B_RAT 458 11 -
SVLENHHLAVGFKLLQE CN4D_HUMAN 409 11 -
SVLENHHLAVGFKLLQE CN4D_RAT 393 11 -
SVLENHHLAVGFKLLQE O35470 524 11 -
SVLENHHLAVGFKLLQE O43433 465 11 -
SVLENHHLAVGFKLLQA CN4C_HUMAN 455 11 -
SILERHHLEFGKTLLRD CNRA_BOVIN 624 10 -
SILERHHLEFGKTLLRD CNRA_CANFA 624 10 -
SILERHHLEFGKTLLRD CNRA_MOUSE 624 10 -
SILERHHLEFGKTLLRD Q29470 625 10 -
SILERHHLEFGKTLLRD CNRA_HUMAN 624 10 -
SILERHHLEFGKFLLSE CNRB_HUMAN 623 10 -
SILERHHLEFGKFLLSE CNRB_CANFA 623 10 -
SILERHHLEFGKFLLSE CNRB_BOVIN 623 10 -
SILERHHLEFGKFLLAE CNRB_MOUSE 623 10 -
SILERHHLEFGKFLLAE Q62037 623 10 -
SILERHHLEYSKTLLQD CNRC_BOVIN 623 10 -
SILERHHLEYSKTLLQD CNRC_CHICK 628 10 -
SVLENHHLAVAFKLLQN CNA1_DROME 314 11 -
SILERHHLEYSKTLLQD CNRC_HUMAN 628 10 -
SVLENHHVSAAYRLMQE CN1A_BOVIN 285 11 -
SVLENHHVSAAYRLMQE Q28063 270 11 -
SVLENHHVSAAYRLMQE CN1A_HUMAN 285 11 -
SVLEQHHLAVAFKLLQD YST1_CAEEL 349 11 -
SIMEHHHFDQCLMILNS O77747 637 10 -
SIMEHHHFDQCLMILNS O77746 669 10 -
SIMEHHHFDQCLMILNS O76074 679 10 -
SIMEHHHFDQCLMILNS O75026 669 10 -
SIMEHHHFDQCLMILNS CN5A_BOVIN 669 10 -
SVLENHHISSVFRMMQD CN1B_BOVIN 288 11 -
SVLENHHISSVFRMMQD CN1B_MOUSE 289 11 -
SVLENHHISSVFRMMQD CN1B_RAT 289 11 -
SVLENHHVSAAYRLMQE CN1A_MOUSE 306 11 -
SVLENHHISSVFRLMQD CN1B_HUMAN 290 11 -
STMEHHHFDQCLMVLNS O54735 637 10 -
SVLERHHFAQTIKLLQQ YNE6_CAEEL 551 14 -
SVLENHHLSAAYRLLQE CN1C_RAT 355 11 -
SVLENHHLSAAYRLLQE CN1C_MOUSE 295 11 -
SVMERHHFAQAIAILNT CN2A_RAT 712 12 -
SVMERHHFAQAIAILNT CN2A_HUMAN 724 12 -
SVMERHHFAQAIAILNT CN2A_BOVIN 704 12 -
SVLENHHLSAAYRLLQD CN1C_HUMAN 295 11 -
SVLENHHVSSCFRLMKE YFGK_CAEEL 400 11 -
SVMERHHFNQTVTILQQ YBZJ_CAEEL 254 10 -

Motif 5 width=14
Element Seqn Id St Int Rpt
VHCADLSNPTKPLE CN4A_HUMAN 587 70 -
VHCADLSNPTKPLE CN4A_RAT 573 70 -
VHCADLSNPTKPLE CN4Z_RAT 339 70 -
VHCADLSNPTKPLE O75522 561 70 -
VHCADLSNPTKPLE O76092 348 70 -
VHCADLSNPTKSLE CN4B_HUMAN 560 70 -
VHCADLSNPTKSLE CN4B_RAT 545 70 -
VHCADLSNPTKPLQ CN4D_HUMAN 496 70 -
VHCADLSNPTKPLQ CN4D_RAT 480 70 -
VHCADLSNPTKPLQ O35470 611 70 -
VHCADLSNPTKPLQ O43433 552 70 -
VHCADLSNPTKPLP CN4C_HUMAN 542 70 -
MTACDLSAITKPWE CNRA_BOVIN 715 74 -
MTACDLSAITKPWE CNRA_CANFA 715 74 -
MTACDLSAITKPWE CNRA_MOUSE 715 74 -
MTACDLSAITKPWE Q29470 716 74 -
MTACDLSAITKPWE CNRA_HUMAN 715 74 -
MTACDLSAITKPWE CNRB_HUMAN 714 74 -
MTACDLSAITKPWE CNRB_CANFA 714 74 -
MTACDLSAITKPWE CNRB_BOVIN 714 74 -
MTACDLSAITKPWE CNRB_MOUSE 714 74 -
MTACDLSAITKPWE Q62037 714 74 -
MTACDLSAITKPWE CNRC_BOVIN 714 74 -
MTGCDLSAITKPWE CNRC_CHICK 719 74 -
VHCADLSNPTKPLP CNA1_DROME 401 70 -
MTACDLSAITKPWE CNRC_HUMAN 719 74 -
LHAADISHPAKSWK CN1A_BOVIN 361 59 -
LHAADISHPAKSWK Q28063 346 59 -
LHAADISHPAKSWK CN1A_HUMAN 361 59 -
IHLADLSNPTKPIE YST1_CAEEL 436 70 -
MTACDLSAITKPWP O77747 718 64 -
MTACDLSAITKPWP O77746 750 64 -
MTACDLSAITKPWP O76074 760 64 -
MTACDLSAITKPWP O75026 750 64 -
MTACDLSAITKPWP CN5A_BOVIN 750 64 -
LHAADISHPTKQWS CN1B_BOVIN 364 59 -
LHAADISHPTKQWS CN1B_MOUSE 365 59 -
LHAADISHPTKQWS CN1B_RAT 365 59 -
LHAADISHPAKTWK CN1A_MOUSE 382 59 -
LHAADISHPTKQWL CN1B_HUMAN 366 59 -
MTACDLSAITKPWP O54735 718 64 -
MTASDLSDQAKNFH YNE6_CAEEL 631 63 -
LHTADISHPAKAWD CN1C_RAT 432 60 -
LHTADISHPAKAWD CN1C_MOUSE 372 60 -
MTSCDLSDQTKGWK CN2A_RAT 792 63 -
MTSCDLSDQTKGWK CN2A_HUMAN 804 63 -
MTSCDLSDQTKGWK CN2A_BOVIN 784 63 -
LHTADISHPAKAWD CN1C_HUMAN 372 60 -
VHACDISHPAKPWN YFGK_CAEEL 476 59 -
MTGCDLVASAKPWN YBZJ_CAEEL 335 64 -

Motif 6 width=17
Element Seqn Id St Int Rpt
QWTDRIMAEFFQQGDRE CN4A_HUMAN 604 3 -
QWTDRIMAEFFQQGDRE CN4A_RAT 590 3 -
QWTDRIMAEFFQQGDRE CN4Z_RAT 356 3 -
QWTDRIMAEFFQQGDRE O75522 578 3 -
QWTDRIMAEFFQQGDRE O76092 365 3 -
QWTDRIMEEFFQQGDKE CN4B_HUMAN 577 3 -
QWTDRIMEEFFQQGDKE CN4B_RAT 562 3 -
QWTDRIMEEFFRQGDRE CN4D_HUMAN 513 3 -
QWTDRIMEEFFRQGDRE CN4D_RAT 497 3 -
QWTDRIMEEFFRQGDRE O35470 628 3 -
QWTDRIMEEFFRQGDRE O43433 569 3 -
QWTDRIMAEFFQQGDRE CN4C_HUMAN 559 3 -
KVALLVAAEFWEQGDLE CNRA_BOVIN 732 3 -
KVALLVAAEFWEQGDLE CNRA_CANFA 732 3 -
KVALLVAAEFWEQGDLE CNRA_MOUSE 732 3 -
KVALLVAAEFWEQGDLE Q29470 733 3 -
QVALLVAAEFWEQGDLE CNRA_HUMAN 732 3 -
KVALLVAAEFWEQGDLE CNRB_HUMAN 731 3 -
KVALLVAAEFWEQGDLE CNRB_CANFA 731 3 -
KVALLVAAEFWEQGDLE CNRB_BOVIN 731 3 -
KVALLVAAEFWEQGDLE CNRB_MOUSE 731 3 -
KVALLVAAEFWEQGDLE Q62037 731 3 -
QVALLVANEFWEQGDLE CNRC_BOVIN 731 3 -
KVALMVANEFWEQGDLE CNRC_CHICK 736 3 -
RWVALLMEEFFLQGDKE CNA1_DROME 418 3 -
QVALMVANEFWEQGDLE CNRC_HUMAN 736 3 -
RWTMALMEEFFLQGDKE CN1A_BOVIN 378 3 -
RWTMALMEEFFLQGDKE Q28063 363 3 -
RWTMALMEEFFLQGDKE CN1A_HUMAN 378 3 -
QWNQRIMEEYWRQGDKE YST1_CAEEL 453 3 -
RIAELVATEFFDQGDRE O77747 735 3 -
RIAELVATEFFDQGDRE O77746 767 3 -
RIAELVATEFFDQGDRE O76074 777 3 -
RIAELVATEFFDQGDRE O75026 767 3 -
RIAELVATEFFDQGDRE CN5A_BOVIN 767 3 -
RWTKALMEEFFRQGDKE CN1B_BOVIN 381 3 -
RWTKALMEEFFRQGDKE CN1B_MOUSE 382 3 -
RWTKALMEEFFRQGDKE CN1B_RAT 382 3 -
RWTMALMEEFFLQGDKE CN1A_MOUSE 399 3 -
RWTKALMEEFFRQGDKE CN1B_HUMAN 383 3 -
RIAELVAAEFFDQGDRE O54735 735 3 -
RIAENIYLEFFAQGDLE YNE6_CAEEL 648 3 -
RWTMSLLEEFFRQGDRE CN1C_RAT 449 3 -
RWTMSLLEEFFRQGDRE CN1C_MOUSE 389 3 -
KIAELIYKEFFSQGDLE CN2A_RAT 809 3 -
KIAELIYKEFFSQGDLE CN2A_HUMAN 821 3 -
KIAELIYKEFFSQGDLE CN2A_BOVIN 801 3 -
RWTMSLLEEFFRQGDRE CN1C_HUMAN 389 3 -
RWTEGVLEEFFRQGDLE YFGK_CAEEL 493 3 -
ETVKVIFEEFYDQGDAE YBZJ_CAEEL 352 3 -