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PR00376

Identifier
IL1BCENZYME  [View Relations]  [View Alignment]  
Accession
PR00376
No. of Motifs
7
Creation Date
25-APR-1995  (UPDATE 20-JUN-1999)
Title
Interleukin-1B converting enzyme signature
Database References

INTERPRO; IPR002398
Literature References
1. DINARELLO, C.A.
The interleukin-1 family - 10 years of discovery.
FASEB J. 8(15) 1314-1325 (1994).
 
2. HOWARD, A.D., KOSTURA, M.J., THORNBERRY, N., DING, G.J.F., LIMJUCO, G.,
WEIDNER, J., SALLEY, J.P., HOGQUIST, K.A., CHAPLIN, D.D., MUMFORD, R.A.,
SCHMIDT, J.A. AND TOCCI, M.J.
IL-1-converting enzyme requires aspartic acid residues for processing of
the IL-1B precursor at 2 distinct sites and does not cleave 31kDa IL-1A.
J.IMMUNOL. 147(9) 2964-2969 (1991).
 
3. WANG, L., MIURA, M., BERGERON, L., ZHU, H. AND YUAN, J.Y.
ICH-1, an ICE/CED-3-related gene, encodes both positive and negative
regulators of programmed cell death.
CELL 78(5) 739-750 (1994).
 
4. KUIDA, K., LIPPKE, J.A., KU, G., HARDING, M.W., LIVINGSTONE, D.J.,
S.-S., MICHAEL AND FLAVELL, R.A.
Altered cytokine export and apoptosis in mice deficient in interleukin-1B
converting enzyme.
SCIENCE 267 2000-2003 (1995).

Documentation
Interleukin-1B (IL-1B) converting enzyme (ICE) processes the inactive IL-1B
precursor to the proinflammatory cytokine, which plays a central role in
acute and chronic inflammation, bone resorption, myelogenous leukemia, and
other pathological processes [1]. ICE is a cysteine protease with substrate
cleavage specificity for Asp-X [2]. It is synthesised largely in monocytes
as an inactive proenzyme that autoprocesses to an active tetramer of 2
10kDa and 2 20KDa subunits. The physiological functions of the mammalian
ICE homologues are unknown, but overexpression of ICE and its homologues in
transfected cell lines induces apoptosis [3,4]
 
IL1BCENZYME is a 7-element fingerprint that provides a signature for
interleukin-1B converting enzymes. The fingerprint was derived from an
initial alignment of 6 sequences: the motifs were drawn from short
conserved regions spanning the C-terminal half of the alignment. Two
iterations on OWL25.2 were required to reach convergence, at which point
a true set comprising 8 sequences was identified. Two partial matches
were also found: HSU13022 is a fragment lacking the final 2 motifs,
and NED2_MOUSE is a murine NEDD-2 sequence that lacks the first 5 motifs.
 
An update on SPTR37_9f identified a true set of 33 sequences, and 12
partial matches.
Summary Information
  33 codes involving  7 elements
4 codes involving 6 elements
7 codes involving 5 elements
1 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
733333333333333
64443441
57716770
40100111
30000000
20000000
1234567
True Positives
CED3_CAEEL    CED3_CAEVU    I1BC_HUMAN    I1BC_MOUSE    
I1BC_RAT ICE1_DROME ICE2_CHICK ICE2_HUMAN
ICE2_MOUSE ICE3_CRILO ICE3_HUMAN ICE3_MOUSE
ICE3_RAT ICE3_XENLA ICE4_HUMAN ICE5_HUMAN
ICE6_HUMAN ICE6_MOUSE ICE7_HUMAN ICE7_MESAU
ICE7_MOUSE ICEA_XENLA ICEB_MOUSE ICEB_XENLA
ICEC_MOUSE ICE_DROME O35397 O42284
O55194 O75601 O88550 O93415
O93417
True Positive Partials
Codes involving 6 elements
ICE1_SPOFR ICE9_HUMAN O02229 O18203
Codes involving 5 elements
ICE8_HUMAN ICEA_HUMAN O02433 O14676
O76797 O76798 O89110
Codes involving 4 elements
O89094
Sequence Titles
CED3_CAEEL  CELL DEATH PROTEIN 3 PRECURSOR (EC 3.4.22.-) - CAENORHABDITIS ELEGANS. 
CED3_CAEVU CELL DEATH PROTEIN 3 PRECURSOR (EC 3.4.22.-) - CAENORHABDITIS VULGARIS.
I1BC_HUMAN INTERLEUKIN-1 BETA CONVERTASE PRECURSOR (IL-1BC) (EC 3.4.22.36) (IL-1 BETA CONVERTING ENZYME) (ICE) (INTERLEUKIN-1 BETA CONVERTING ENZYME) (P45) (CASPASE-1) (CASP-1) - HOMO SAPIENS (HUMAN).
I1BC_MOUSE INTERLEUKIN-1 BETA CONVERTASE PRECURSOR (IL-1BC) (EC 3.4.22.36) (IL-1 BETA CONVERTING ENZYME) (ICE) (INTERLEUKIN-1 BETA CONVERTING ENZYME) (P45) (CASPASE-1) (CASP-1) - MUS MUSCULUS (MOUSE).
I1BC_RAT INTERLEUKIN-1 BETA CONVERTASE PRECURSOR (IL-1BC) (EC 3.4.22.36) (IL-1 BETA CONVERTING ENZYME) (ICE) (INTERLEUKIN-1 BETA CONVERTING ENZYME) (P45) (CASPASE-1) (CASP-1) - RATTUS NORVEGICUS (RAT).
ICE1_DROME CASPASE-1 PRECURSOR (EC 3.4.22.-) - DROSOPHILA MELANOGASTER (FRUIT FLY).
ICE2_CHICK CASPASE-2 PRECURSOR (EC 3.4.22.-) (CASP-2) (ICH-1 PROTEASE) (ICH- 1L/1S) - GALLUS GALLUS (CHICKEN).
ICE2_HUMAN CASPASE-2 PRECURSOR (EC 3.4.22.-) (CASP-2) (ICH-1 PROTEASE) (ICH- 1L/1S) - HOMO SAPIENS (HUMAN).
ICE2_MOUSE CASPASE-2 PRECURSOR (EC 3.4.22.-) (CASP-2) (ICH-1 PROTEASE) (NEDD2 PROTEIN) - MUS MUSCULUS (MOUSE).
ICE3_CRILO APOPAIN PRECURSOR (EC 3.4.22.-) (CYSTEINE PROTEASE CPP32) (YAMA PROTEIN) (CPP-32) (CASPASE-3) (CASP-3) (SREBP CLEAVAGE ACTIVITY 1) (SCA-1) - CRICETULUS LONGICAUDATUS (LONG-TAILED HAMSTER) (CHINESE HAMSTER).
ICE3_HUMAN APOPAIN PRECURSOR (EC 3.4.22.-) (CYSTEINE PROTEASE CPP32) (YAMA PROTEIN) (CPP-32) (CASPASE-3) (CASP-3) (SREBP CLEAVAGE ACTIVITY 1) (SCA-1) - HOMO SAPIENS (HUMAN).
ICE3_MOUSE APOPAIN PRECURSOR (EC 3.4.22.-) (CYSTEINE PROTEASE CPP32) (YAMA PROTEIN) (CPP-32) (CASPASE-3) (CASP-3) (SREBP CLEAVAGE ACTIVITY 1) (SCA-1) (LICE) - MUS MUSCULUS (MOUSE).
ICE3_RAT APOPAIN PRECURSOR (EC 3.4.22.-) (CYSTEINE PROTEASE CPP32) (YAMA PROTEIN) (CPP-32) (CASPASE-3) (CASP-3) (SREBP CLEAVAGE ACTIVITY 1) (SCA-1) (LICE) (IRP) - RATTUS NORVEGICUS (RAT).
ICE3_XENLA APOPAIN PRECURSOR (EC 3.4.22.-) (CYSTEINE PROTEASE CPP32) (CASPASE-3) (CASP-3) (XCPP32) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
ICE4_HUMAN CASPASE-4 PRECURSOR (EC 3.4.22.-) (CASP-4) (ICH-2 PROTEASE) (TX PROTEASE) (ICE(REL)-II) - HOMO SAPIENS (HUMAN).
ICE5_HUMAN CASPASE-5 PRECURSOR (EC 3.4.22.-) (ICH-3 PROTEASE) (TY PROTEASE) (ICE(REL)-III) - HOMO SAPIENS (HUMAN).
ICE6_HUMAN CASPASE-6 PRECURSOR (EC 3.4.22.-) (APOPTOTIC PROTEASE MCH-2) - HOMO SAPIENS (HUMAN).
ICE6_MOUSE CASPASE-6 PRECURSOR (EC 3.4.22.-) (APOPTOTIC PROTEASE MCH-2) - MUS MUSCULUS (MOUSE).
ICE7_HUMAN CASPASE-7 PRECURSOR (EC 3.4.22.-) (ICE-LIKE APOPTOTIC PROTEASE 3) (ICE-LAP3) (APOPTOTIC PROTEASE MCH-3) (CMH-1) - HOMO SAPIENS (HUMAN).
ICE7_MESAU CASPASE-7 PRECURSOR (EC 3.4.22.-) (ICE-LIKE APOPTOTIC PROTEASE 3) (ICE-LAP3) (APOPTOTIC PROTEASE MCH-3) (SREBP CLEAVAGE ACTIVITY 2) (SCA-2) - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
ICE7_MOUSE CASPASE-7 PRECURSOR (EC 3.4.22.-) (LICE2 CYSTEINE PROTEASE) (APOPTOTIC PROTEASE MCH-3) - MUS MUSCULUS (MOUSE).
ICEA_XENLA INTERLEUKIN-1 BETA CONVERTASE HOMOLOG A PRECURSOR (EC 3.4.22.-) (XICE-A) (CASPASE-1A) (CASP-1A) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
ICEB_MOUSE CASPASE-11 PRECURSOR (EC 3.4.22.-) (ICH-3 PROTEASE) - MUS MUSCULUS (MOUSE).
ICEB_XENLA INTERLEUKIN-1 BETA CONVERTASE HOMOLOG B PRECURSOR (EC 3.4.22.-) (XICE-B) (CASPASE-1B) (CASP-1B) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
ICEC_MOUSE CASPASE-12 PRECURSOR (EC 3.4.22.-) - MUS MUSCULUS (MOUSE).
ICE_DROME CASPASE PRECURSOR (EC 3.4.22.-) (DRICE) - DROSOPHILA MELANOGASTER (FRUIT FLY).
O35397 CASPASE 6 - RATTUS NORVEGICUS (RAT).
O42284 CASPASE-1 - GALLUS GALLUS (CHICKEN).
O55194 NEDD2/ICH-1 - RATTUS NORVEGICUS (RAT).
O75601 EVOLUTIONARILY RELATED INTERLEUKIN-1BETA CONVERTING ENZYME - HOMO SAPIENS (HUMAN).
O88550 CASPASE-7 - RATTUS NORVEGICUS (RAT).
O93415 CASPASE-6 - GALLUS GALLUS (CHICKEN).
O93417 CASPASE-3 - GALLUS GALLUS (CHICKEN).

ICE1_SPOFR CASPASE-1 PRECURSOR (EC 3.4.22.-) - SPODOPTERA FRUGIPERDA (FALL ARMYWORM).
ICE9_HUMAN CASPASE-9 PRECURSOR (EC 3.4.22.-) (CASP-9) (ICE-LIKE APOPTOTIC PROTEASE 6) (ICE-LAP6) (APOPTOTIC PROTEASE MCH-6) (APOPTOTIC PROTEASE ACTIVATING FACTOR 3) (APAF-3) - HOMO SAPIENS (HUMAN).
O02229 C48D1.2 PROTEIN - CAENORHABDITIS ELEGANS.
O18203 Y48E1B.13 PROTEIN - CAENORHABDITIS ELEGANS.

ICE8_HUMAN CASPASE-8 PRECURSOR (EC 3.4.22.-) (ICE-LIKE APOPTOTIC PROTEASE 5) (MORT1-ASSOCIATED CED-3 HOMOLOG) (MACH) (FADD-HOMOLOGOUS ICE/CED-3- LIKE PROTEASE) (FADD-LIKE ICE) (FLICE) (APOPTOTIC CYSTEINE PROTEASE) (APOPTOTIC PROTEASE MCH-5) (CAP4) - HOMO SAPIENS (HUMAN).
ICEA_HUMAN CASPASE-10 PRECURSOR (EC 3.4.22.-) (ICE-LIKE APOPTOTIC PROTEASE 4) (APOPTOTIC PROTEASE MCH-4) (FAS-ASSOCIATED DEATH DOMAIN PROTEIN INTERLEUKIN-1B-CONVERTING ENZYME 2) (FLICE2) - HOMO SAPIENS (HUMAN).
O02433 DREDD - DROSOPHILA MELANOGASTER (FRUIT FLY).
O14676 APOPTOTIC CASPASE MCH5-BETA - HOMO SAPIENS (HUMAN).
O76797 DREDD ISOFORM DELTA - DROSOPHILA MELANOGASTER (FRUIT FLY).
O76798 DREDD ISOFORM GAMMA - DROSOPHILA MELANOGASTER (FRUIT FLY).
O89110 CASPASE-8 - MUS MUSCULUS (MOUSE).

O89094 CASPASE-14 - MUS MUSCULUS (MOUSE).
Scan History
OWL25_2    2  50   NSINGLE    
SPTR37_9f 3 100 NSINGLE
Initial Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
RTRLALIICNTDFQ RNU14647 160 160 -
EMGLCIIINNKNFH HSU13737 43 43 -
PRGLALVLSNVHFT HSU13021 181 181 -
PRGMCLIINNEHFE A49429 241 241 -
RTRLALIICNEEFD I1BC_HUMAN 161 161 -
RTRLALIICNTEFQ I1BC_MOUSE 160 160 -

Motif 2 width=19
Element Seqn Id St Int Rpt
RSGGDVDHSTLVTLFKLLG HSU13021 202 7 -
RVGADVDLREMKLLLQDLG RNU14647 178 4 -
RSGTDVDAANLRETFRNLK HSU13737 64 7 -
RTGAEVDITGMTMLLQNLG I1BC_HUMAN 179 4 -
RVGAQVDLREMKLLLEDLG I1BC_MOUSE 178 4 -
RNGTKADKDNLTNLFRCMG A49429 259 4 -

Motif 3 width=19
Element Seqn Id St Int Rpt
GYTVKVKENLTALEMVKEV I1BC_MOUSE 196 -1 -
GYTVKVKENLTALEMTKEL RNU14647 196 -1 -
GYTVICKDNLTGRGMLLTI A49429 277 -1 -
GYDVHVLCDQTAQEMQEKL HSU13021 220 -1 -
KYEVRNKNDLTREEIVELM HSU13737 82 -1 -
GYSVDVKKNLTASDMTTEL I1BC_HUMAN 197 -1 -

Motif 4 width=9
Element Seqn Id St Int Rpt
CIVALLSHG HSU13021 253 14 -
AILVILSHG A49429 308 12 -
TFLVFMSHG RNU14647 229 14 -
TFLVFMSHG I1BC_HUMAN 230 14 -
TFLVFMSHG I1BC_MOUSE 229 14 -
FVCVLLSHG HSU13737 114 13 -

Motif 5 width=19
Element Seqn Id St Int Rpt
CPSLKDKPKVIIIQACRGE I1BC_MOUSE 269 31 -
CPSLKDKPKVIIIQACRGE RNU14647 269 31 -
APRLANKPKIVFVQACRGE A49429 343 26 -
CPSLQNKPKMFFIQACRGD HSU13021 288 26 -
CRSLTGKPKLFIIQACRGT HSU13737 148 25 -
CPSLKDKPKVIIIQACRGD I1BC_HUMAN 270 31 -

Motif 6 width=12
Element Seqn Id St Int Rpt
SWRHPVRGSLFI RNU14647 337 49 -
SWRNSKDGSWFI HSU13737 205 38 -
SWRHPVRGSLFI I1BC_MOUSE 337 49 -
SWRHPTMGSVFI I1BC_HUMAN 339 50 -
AMRNTKRGSWYI HSU13021 359 52 -
SWRNSARGSWFI A49429 427 65 -

Motif 7 width=10
Element Seqn Id St Int Rpt
SMLTKELYFY HSU13737 267 50 -
SRLLKKFYFW A49429 486 47 -
VTLTKRFYLF RNU14647 390 41 -
VTLTRCFYLF I1BC_HUMAN 392 41 -
VTLTKRFYLF I1BC_MOUSE 390 41 -
STLCRHLYLF HSU13021 420 49 -
Final Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
EMGLCIIINNKNFH ICE3_HUMAN 43 43 -
EMGLCIIINNKNFH ICE3_RAT 43 43 -
EMGVCIIINNKNFH ICE3_CRILO 43 43 -
EMGICIIINNKNFH ICE3_MOUSE 43 43 -
KMGKCIIINNKNFD O88550 66 66 -
KMGKCIIINNKNFD ICE7_MOUSE 66 66 -
KMGKCIIINNKNFD ICE7_MESAU 66 66 -
RTRLALIICNTDFQ I1BC_RAT 160 160 -
EIGVCVIINNKNFH O93417 51 51 -
RTRLALIICNTEFQ I1BC_MOUSE 160 160 -
EMGMCLIINNKNFH ICE3_XENLA 54 54 -
RTRLALIICNEEFD I1BC_HUMAN 161 161 -
KLGKCIIINNKNFD ICE7_HUMAN 66 66 -
RRGVALIFNHEHFF O93415 55 55 -
RKGLALIICNEKFE ICEA_XENLA 142 142 -
RRRLALIICNTKFD ICE5_HUMAN 175 175 -
RRGVALIFNHERFF ICE6_MOUSE 26 26 -
RRGIALIFNHERFF ICE6_HUMAN 43 43 -
RKRLALIICNETFQ ICEB_XENLA 140 140 -
RRGTALIFNHERFF O35397 26 26 -
RTRLALIICNTEFD O75601 134 134 -
PRGMCLIINNEHFE CED3_CAEEL 241 241 -
PRGLALILSNIHFS ICE2_CHICK 169 169 -
PRGLALVLSNVHFT ICE2_HUMAN 181 181 -
RTRLALIICNTEFD ICE4_HUMAN 134 134 -
PRGLALVLSNVHFT ICE2_MOUSE 181 181 -
RTRKALIICNTEFK ICEB_MOUSE 130 130 -
PRGLALVMSNVHFT O55194 198 198 -
PRGLCLIINNEHFE CED3_CAEVU 235 235 -
RTRLALIICNKKFD ICEC_MOUSE 174 174 -
RTRRALLICNTKFK O42284 40 40 -
HRGVALIFNHEFFD ICE1_DROME 77 77 -
NRGMALIFNHEHFE ICE_DROME 92 92 -

Motif 2 width=19
Element Seqn Id St Int Rpt
RSGTDVDAANLRETFRNLK ICE3_HUMAN 64 7 -
RNGTDVDAANLRETFMALK ICE3_RAT 64 7 -
RSGTDVDAAKLRETFMALK ICE3_CRILO 64 7 -
RSGTDVDAANLRETFMGLK ICE3_MOUSE 64 7 -
RNGTDKDAEALFKCFRSLG O88550 87 7 -
RNGTDKDAGALFKCFQNLG ICE7_MOUSE 87 7 -
RNGTDKDAEALFKCFRSLG ICE7_MESAU 87 7 -
RVGADVDLREMKLLLQDLG I1BC_RAT 178 4 -
RSGTDADAASVREVFMKLG O93417 72 7 -
RVGAQVDLREMKLLLEDLG I1BC_MOUSE 178 4 -
RNGTDVDALKLHETFTGLG ICE3_XENLA 74 6 -
RTGAEVDITGMTMLLQNLG I1BC_HUMAN 179 4 -
RNGTDKDAEALFKCFRSLG ICE7_HUMAN 87 7 -
RRGTLADRNNLKRSLTDLG O93415 76 7 -
RHGAKVDLDGMTKLLNELG ICEA_XENLA 160 4 -
RNGAHYDIVGMKRLLQGLG ICE5_HUMAN 193 4 -
RRGTNADRDNLTRRFSDLG ICE6_MOUSE 47 7 -
RRRTCADRDNLTRRFSDLG ICE6_HUMAN 64 7 -
RRGAKLDLEGMNKLLNELG ICEB_XENLA 158 4 -
RRGTNADRDNPTRRFSELG O35397 47 7 -
RNGAALDILGMKQLLEGLG O75601 152 4 -
RNGTKADKDNLTNLFRCMG CED3_CAEEL 259 4 -
RSGGDVDCASLELLFKHLG ICE2_CHICK 190 7 -
RSGGDVDHSTLVTLFKLLG ICE2_HUMAN 202 7 -
RNGADFDITGMKELLEGLD ICE4_HUMAN 152 4 -
RSGGDVDHTTLVTLFKLLG ICE2_MOUSE 202 7 -
RYGAKFDIIGMKGLLEDLG ICEB_MOUSE 148 4 -
RSGGDVDHTTLVTLFKLLG O55194 219 7 -
RNGTKADKDNLTNIFRCMG CED3_CAEVU 253 4 -
RDNADTDILNMQELLENLG ICEC_MOUSE 192 4 -
RDGAEVDVKEMTKLLEGLG O42284 58 4 -
RTGTNVDAQELKKAFENLG ICE1_DROME 97 6 -
RAGTNVDCENLTRVLKQLD ICE_DROME 112 6 -

Motif 3 width=19
Element Seqn Id St Int Rpt
KYEVRNKNDLTREEIVELM ICE3_HUMAN 82 -1 -
KYEVRNKNDLTREEIMELM ICE3_RAT 82 -1 -
KYEVRNKNDLTREEIVELM ICE3_CRILO 82 -1 -
KYQVRNKNDLTREDILELM ICE3_MOUSE 82 -1 -
GFEVTVYNDCSCAKMQDLL O88550 105 -1 -
GFEVTVHNDCSCAKMQDLL ICE7_MOUSE 105 -1 -
GFDVVVYNDCSCAKMQDLL ICE7_MESAU 105 -1 -
GYTVKVKENLTALEMTKEL I1BC_RAT 196 -1 -
GYKVKLNNDLSSRDIFKLL O93417 90 -1 -
GYTVKVKENLTALEMVKEV I1BC_MOUSE 196 -1 -
GYEVMVCNDQKSSDIIGRL ICE3_XENLA 92 -1 -
GYSVDVKKNLTASDMTTEL I1BC_HUMAN 197 -1 -
GFDVIVYNDCSCAKMQDLL ICE7_HUMAN 105 -1 -
GFEVRIFDDLKAEDVLKKV O93415 94 -1 -
GYQVHPHTNLTKTEMVKVM ICEA_XENLA 178 -1 -
GYTVVDEKNLTARDMESVL ICE5_HUMAN 211 -1 -
GFEVKCFNDLRAEELLLKI ICE6_MOUSE 65 -1 -
GFEVKCFNDLKAEELLLKI ICE6_HUMAN 82 -1 -
GYQVQQHTNLTKAEMVKAM ICEB_XENLA 176 -1 -
GFEVKCFNDLRAEELLLKI O35397 65 -1 -
GYTVEVEEKLTARDMESVL O75601 170 -1 -
GYTVICKDNLTGRGMLLTI CED3_CAEEL 277 -1 -
GYQVTVFHDQSAEEMESAL ICE2_CHICK 208 -1 -
GYDVHVLCDQTAQEMQEKL ICE2_HUMAN 220 -1 -
DYSVDVEENLTARDMESAL ICE4_HUMAN 170 -1 -
GYNVHVLHDQTAQEMQEKL ICE2_MOUSE 220 -1 -
GYDVVVKEELTAEGMESEM ICEB_MOUSE 166 -1 -
GYNVHVLYDQTAQEMQEKL O55194 237 -1 -
GYTVICKDNISGRGMLTIR CED3_CAEVU 271 -1 -
GYSVVLKENLTAQEMETEL ICEC_MOUSE 210 -1 -
GYNVECHEDKTSQEMTTVM O42284 76 -1 -
GFAVSVHKDCKLRDILKHV ICE1_DROME 115 -1 -
DFEVTVYKDCRYKDILRTI ICE_DROME 130 -1 -

Motif 4 width=9
Element Seqn Id St Int Rpt
FVCVLLSHG ICE3_HUMAN 114 13 -
FVCVILSHG ICE3_RAT 114 13 -
FVCVILSHG ICE3_CRILO 114 13 -
FVCVILSHG ICE3_MOUSE 114 13 -
FACVLLSHG O88550 137 13 -
FACVLLSHG ICE7_MOUSE 137 13 -
FACVLLSHG ICE7_MESAU 137 13 -
TFLVFMSHG I1BC_RAT 229 14 -
FVCVLLSHG O93417 122 13 -
TFLVFMSHG I1BC_MOUSE 229 14 -
FVCAILSHG ICE3_XENLA 124 13 -
TFLVFMSHG I1BC_HUMAN 230 14 -
FACILLSHG ICE7_HUMAN 137 13 -
FVCVFLSHG O93415 126 13 -
TFIVLMSHG ICEA_XENLA 211 14 -
TFLVLMSHG ICE5_HUMAN 244 14 -
FICVFLSHG ICE6_MOUSE 97 13 -
FVCVFLSHG ICE6_HUMAN 114 13 -
TFIVLMSHG ICEB_XENLA 209 14 -
FLCVFLSHG O35397 97 13 -
TFLVFMSHG O75601 203 14 -
AILVILSHG CED3_CAEEL 308 12 -
CIVALLSHG ICE2_CHICK 241 14 -
CIVALLSHG ICE2_HUMAN 253 14 -
TFLVLMSHG ICE4_HUMAN 203 14 -
CVVALLSHG ICE2_MOUSE 253 14 -
TFLVLMSHG ICEB_MOUSE 199 14 -
CIVALLSHG O55194 270 14 -
AILVILSHG CED3_CAEVU 301 11 -
TFLVFMSHG ICEC_MOUSE 243 14 -
TFLVFMSHG O42284 109 14 -
LAVAILSHG ICE1_DROME 147 13 -
ILVAILSHG ICE_DROME 162 13 -

Motif 5 width=19
Element Seqn Id St Int Rpt
CRSLTGKPKLFIIQACRGT ICE3_HUMAN 148 25 -
CRSLTGKPKLFIIQACRGT ICE3_RAT 148 25 -
CRSLIGKPKLFIIQACRGT ICE3_CRILO 148 25 -
CRSLTGKPKLFIIQACRGT ICE3_MOUSE 148 25 -
CKTLLEKPKLFFIQACRGT O88550 171 25 -
CKTLLEKPKLFFIQACRGT ICE7_MOUSE 171 25 -
CKTLLEKPKLFFIQACRGT ICE7_MESAU 171 25 -
CPSLKDKPKVIIIQACRGE I1BC_RAT 269 31 -
CRSLAGKPKLFFIQACRGT O93417 156 25 -
CPSLKDKPKVIIIQACRGE I1BC_MOUSE 269 31 -
CKTLVGKPKIFFIQACRGT ICE3_XENLA 159 26 -
CPSLKDKPKVIIIQACRGD I1BC_HUMAN 270 31 -
CKTLLEKPKLFFIQACRGT ICE7_HUMAN 171 25 -
CQSLVGKPKIFIIQACRGD O93415 160 25 -
CSKLRNKPKVIIIQACRGE ICEA_XENLA 259 39 -
CLSLKDKPKVIIVQACRGE ICE5_HUMAN 284 31 -
CQSLVGKPKIFIIQACRGS ICE6_MOUSE 131 25 -
CHSLVGKPKIFIIQACRGN ICE6_HUMAN 148 25 -
CSRLWDKPKVIIIQACRGE ICEB_XENLA 255 37 -
CQSLVGKPKIFIIQACRGS O35397 131 25 -
CLSLKDKPKVIIVQACRGA O75601 243 31 -
APRLANKPKIVFVQACRGE CED3_CAEEL 343 26 -
CPNLQNKPKMFFIQACRGD ICE2_CHICK 276 26 -
CPSLQNKPKMFFIQACRGD ICE2_HUMAN 288 26 -
CLSLKDKPKVIIVQACRGA ICE4_HUMAN 243 31 -
CPSLQNKPKMFFIQACRGD ICE2_MOUSE 288 26 -
CPGLRDKPKVIIVQACRGG ICEB_MOUSE 239 31 -
CPSLQNKPKMFFIQACRGD O55194 305 26 -
APRLANKPKLVFVQACRGE CED3_CAEVU 336 26 -
CRSLRNKPKILIMQACRGR ICEC_MOUSE 283 31 -
CRALMGKPKVVIIQCCRGD O42284 148 30 -
CPSLAGKPKLFFIQACQGD ICE1_DROME 181 25 -
CPSLAGKPKLFFIQACQGD ICE_DROME 196 25 -

Motif 6 width=12
Element Seqn Id St Int Rpt
SWRNSKDGSWFI ICE3_HUMAN 205 38 -
SWRNSRDGSWFI ICE3_RAT 205 38 -
SWRNPKDGSWFI ICE3_CRILO 205 38 -
SWRNSKDGSWFI ICE3_MOUSE 205 38 -
SWRNPGKGSWFV O88550 231 41 -
SWRNPGKGSWFV ICE7_MOUSE 231 41 -
SWRNPGKGSWFV ICE7_MESAU 231 41 -
SWRHPVRGSLFI I1BC_RAT 337 49 -
SWRNAAEGSWFI O93417 212 37 -
SWRHPVRGSLFI I1BC_MOUSE 337 49 -
SWRDKMDGSWFI ICE3_XENLA 216 38 -
SWRHPTMGSVFI I1BC_HUMAN 339 50 -
SWRSPGRGSWFV ICE7_HUMAN 231 41 -
SHRETVNGSWYI O93415 229 50 -
SWRDPTKGSVFI ICEA_XENLA 319 41 -
SWRDRTRGSIFI ICE5_HUMAN 353 50 -
SHRETVNGSWYI ICE6_MOUSE 200 50 -
SHRETVNGSWYI ICE6_HUMAN 218 51 -
SWRNPTKGSVFI ICEB_XENLA 315 41 -
SHRETVNGSWYI O35397 201 51 -
SWRDIKKGSLFI O75601 312 50 -
SWRNSARGSWFI CED3_CAEEL 427 65 -
AMRNTKRGSWYI ICE2_CHICK 347 52 -
AMRNTKRGSWYI ICE2_HUMAN 359 52 -
SWRDSTMGSIFI ICE4_HUMAN 312 50 -
AMRNTKRGSWYI ICE2_MOUSE 359 52 -
SYRDKTGGSYFI ICEB_MOUSE 308 50 -
AMRNTKRGSWYI O55194 376 52 -
SWRNSARGSWFI CED3_CAEVU 418 63 -
SWKVGKTGSLFI ICEC_MOUSE 354 52 -
SWRSPTEGSVFI O42284 220 53 -
SWRNINNGSWYM ICE1_DROME 242 42 -
SWRNTTRGTWFM ICE_DROME 257 42 -

Motif 7 width=10
Element Seqn Id St Int Rpt
SMLTKELYFY ICE3_HUMAN 267 50 -
SMLTKELYFY ICE3_RAT 267 50 -
SMLTKELYFY ICE3_CRILO 267 50 -
SMLTKELYFY ICE3_MOUSE 267 50 -
SMLTKELYFG O88550 293 50 -
SMLTKELYFS ICE7_MOUSE 293 50 -
SMLTKELYFG ICE7_MESAU 293 50 -
VTLTKRFYLF I1BC_RAT 390 41 -
SMLTKEFYFP O93417 273 49 -
VTLTKRFYLF I1BC_MOUSE 390 41 -
SMLTKSFYFF ICE3_XENLA 272 44 -
VTLTRCFYLF I1BC_HUMAN 392 41 -
SMLTKELYFS ICE7_HUMAN 293 50 -
SMLTKKLYFH O93415 291 50 -
CTLTKKFYLF ICEA_XENLA 374 43 -
ATLTRDFYLF ICE5_HUMAN 406 41 -
SMLTKKLHFC ICE6_MOUSE 262 50 -
SMLTKKLHFF ICE6_HUMAN 280 50 -
STMTKKFYLF ICEB_XENLA 370 43 -
SMLTKKLHFC O35397 263 50 -
LSMTRYFYLF O75601 365 41 -
SRLLKKFYFW CED3_CAEEL 486 47 -
STLCRDLYLF ICE2_CHICK 408 49 -
STLCRHLYLF ICE2_HUMAN 420 49 -
LSMTRYFYLF ICE4_HUMAN 365 41 -
STLCQQLYLF ICE2_MOUSE 420 49 -
ATLTRYFYLF ICEB_MOUSE 361 41 -
STLCQQLYLF O55194 437 49 -
SRLLKKFYFW CED3_CAEVU 477 47 -
VSMTRYFYLF ICEC_MOUSE 407 41 -
TTMLKKFYLF O42284 271 39 -
SMLTRILRFG ICE1_DROME 305 51 -
TMLTRILRFS ICE_DROME 320 51 -