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PR00179

Identifier
LIPOCALIN  [View Relations]  [View Alignment]  
Accession
PR00179
No. of Motifs
3
Creation Date
05-AUG-1994  (UPDATE 19-JUN-1999)
Title
Lipocalin signature
Database References
PRINTS; PR00708 A1AGLPROTEIN; PR01215 A1MCGLOBULIN; PR01219 APOLIPOPROTD
PRINTS; PR00709 AVIDIN; PR01171 BCTLIPOCALIN; PR01172 BLCTOGLOBULN
PRINTS; PR01220 HISBINDING; PR01273 INVTBRTCOLOR; PR01221 MAJORURINARY
PRINTS; PR01274 MPTASEINHBTR; PR01275 NGELATINASE; PR00788 NITROPHORIN
PRINTS; PR01173 ODORANTBNDNG; PR01254 PGNDSYNTHASE; PR01174 RETINOLBNDNG
PRINTS; PR01175 VNEBNERGLAND
PROSITE; PS00213 LIPOCALIN
PFAM; PF00061 lipocalin
INTERPRO; IPR002345
PDB; 1RBP
SCOP; 1RBP
CATH; 1RBP
Literature References
1. PERVAIS, S. AND BREW, K. 
Homology of beta-lactoglobulin, serum retinol-binding protein and 
protein HC.
SCIENCE 228 335-337 (1985).
 
2. FLOWER, D.R., NORTH, A.C.T. AND ATTWOOD, T.K. 
Mouse oncogene protein 24p3 is a member of the lipocalin protein family.
BIOCHEM.BIOPHYS.RES.COMMUN. 180(1) 69-74 (1991).
 
3. FLOWER, D.R., NORTH, A.C.T. AND ATTWOOD, T.K.
Structural and sequence relationships in the lipocalins and related
proteins.
PROTEIN SCI. 2 753-761 (1993). 
 
4. FLOWER, D.R.
Multiple molecular recognition properties of the lipocalin protein family.
J.MOL.REC. 8 185-195 (1995).

Documentation
The lipocalins are a diverse, interesting, yet poorly understood family of 
proteins composed, in the main, of extracellular ligand-binding proteins
displaying high specificity for small hydrophobic molecules [1]. Functions
of these proteins include transport of nutrients, control of cell regula-
tion, pheromone transport, cryptic colouration, and the enzymatic synthesis
of prostaglandins.
 
The crystal structures of several lipocalins have been solved and show a 
novel 8-stranded anti-parallel beta-barrel fold well conserved within the
family. Sequence similarity within the family is at a much lower level and
would seem to be restricted to conserved disulphides and 3 motifs, which
form a juxtaposed cluster that may act as a common cell surface receptor
site [2,3]. By contrast, at the more variable end of the fold are found an 
internal ligand binding site and a putative surface for the formation of 
macromolecular complexes [4]. The anti-parallel beta-barrel fold is also
exploited by the fatty acid-binding proteins, which function similarly by
binding small hydrophobic molecules. Similarity at the sequence level,
however, is less obvious, being confined to a single short N-terminal motif.
 
LIPOCALIN is a 3-element fingerprint that provides a signature for the
lipocalins. The fingerprint was derived from an initial alignment of 6
sequences: motif 1 includes a GxW triplet, which forms part of the first
beta-strand (cf. PROSITE pattern LIPOCALIN (PS00213)); motif 2 encodes a 
TDY triplet, which lies in a conserved region of the barrel involving the
6th and 7th beta-strands and the loop between them; and motif 3 encodes an
Arg (sometimes a Lys) residue, which lies in a structurally conserved
region involving the final strand and part of the loop linking it to the
C-terminal alpha-helix. Five iterations on OWL11.1 were required to reach 
convergence, at which point a true set comprising 51 sequences was 
identified: these included most of the previously known family members, and
one new one -  mouse 24p3 protein [2,3]. Several members, however, were not
diagnosed, including alpha-1-acid glycoprotein, aphrodisin, probasin, 
several odour binding proteins and kangaroo beta-lactoglobulin-like protein.
Four partial matches were also found, including a now-corrected error in 
sequencing, a fragment lacking the portion of sequence bearing motif 3, and
2 putative family members that lack one of the 3 motifs. The results suggest
that a core, structurally well-conserved and self-consistent family can be
defined, together with a group of outliers, which show some similarity to 
the family but fail to match all motifs well [3].
 
An update on SPTR37_9f identified a true set of 74 sequences, and 19
partial matches.
Summary Information
  74 codes involving  3 elements
19 codes involving 2 elements
Composite Feature Index
3747474
218713
123
True Positives
AMBP_BOVIN    AMBP_HUMAN    AMBP_MERUN    AMBP_MESAU    
AMBP_MOUSE AMBP_RAT APOD_HUMAN APOD_MOUSE
APOD_RABIT APOD_RAT BBP_PIEBR CO8G_HUMAN
CRA2_HOMGA ERBP_RAT ESP4_LACVV LACA_CANFA
LACA_EQUAS LACA_FELCA LACA_HORSE LACB_BOVIN
LACB_BUBAR LACB_CAPHI LACB_EQUAS LACB_FELCA
LACB_HORSE LACB_PIG LACB_SHEEP LACC_CANFA
LACC_FELCA LIPO_BUFMA MUP1_MOUSE MUP2_MOUSE
MUP4_MOUSE MUP5_MOUSE MUP6_MOUSE MUPM_MOUSE
MUP_RAT NGAL_HUMAN NGAL_MOUSE NGAL_RAT
O62822 O70160 O88787 P70004
PGHD_BOVIN PGHD_FELCA PGHD_HUMAN PGHD_MOUSE
PGHD_PIG PGHD_RAT PGHD_URSAR PP14_HUMAN
PURP_CHICK Q00629 Q24996 Q28369
Q28679 Q61921 Q63024 Q63025
Q63213 Q91721 Q92136 QSP_CHICK
RET1_ONCMY RET2_ONCMY RETB_BOVIN RETB_CHICK
RETB_HUMAN RETB_MOUSE RETB_PIG RETB_RABIT
RETB_RAT RETB_XENLA
True Positive Partials
Codes involving 2 elements
A1AI_MOUSE ALL1_CANFA ALL1_HORSE APOD_CAVPO
BLC_ECOLI BLC_VIBCH CRC1_HOMGA ICYA_MANSE
ICYB_MANSE LAZA_SCHAM O31025 O35091
OLFA_RANPI Q28388 VEG1_RAT VEG2_RAT
VEGP_HUMAN VEGP_PIG VNS1_MOUSE
Sequence Titles
AMBP_BOVIN  AMBP PROTEIN PRECURSOR [CONTAINS: ALPHA-1-MICROGLOBULIN; INTER-ALPHA- TRYPSIN INHIBITOR LIGHT CHAIN (ITI-LC) (BIKUNIN) (HI-30) (BI-14) (CUMULUS EXTRACELLULAR MATRIX STABILIZING FACTOR) (ESF)] - BOS TAURUS (BOVINE). 
AMBP_HUMAN AMBP PROTEIN PRECURSOR [CONTAINS: ALPHA-1-MICROGLOBULIN (PROTEIN HC) (COMPLEX-FORMING GLYCOPROTEIN HETEROGENEOUS IN CHARGE); INTER-ALPHA- TRYPSIN INHIBITOR LIGHT CHAIN (ITI-LC) (BIKUNIN) (HI-30)] - HOMO SAPIENS (HUMAN).
AMBP_MERUN AMBP PROTEIN PRECURSOR [CONTAINS: ALPHA-1-MICROGLOBULIN; INTER-ALPHA- TRYPSIN INHIBITOR LIGHT CHAIN (ITI-LC) (BIKUNIN) (HI-30)] - MERIONES UNGUICULATUS (MONGOLIAN JIRD).
AMBP_MESAU AMBP PROTEIN PRECURSOR [CONTAINS: ALPHA-1-MICROGLOBULIN; INTER-ALPHA- TRYPSIN INHIBITOR LIGHT CHAIN (ITI-LC) (BIKUNIN) (HI-30)] - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
AMBP_MOUSE AMBP PROTEIN PRECURSOR [CONTAINS: ALPHA-1-MICROGLOBULIN; INTER-ALPHA- TRYPSIN INHIBITOR LIGHT CHAIN (ITI-LC) (BIKUNIN) (HI-30)] - MUS MUSCULUS (MOUSE).
AMBP_RAT AMBP PROTEIN PRECURSOR [CONTAINS: ALPHA-1-MICROGLOBULIN; INTER-ALPHA- TRYPSIN INHIBITOR LIGHT CHAIN (ITI-LC) (BIKUNIN) (HI-30)] - RATTUS NORVEGICUS (RAT).
APOD_HUMAN Apolipoprotein D - Homo sapiens
APOD_MOUSE Apolipoprotein D - Mus musculus
APOD_RABIT Apolipoprotein D - Oryctolagus cuniculus
APOD_RAT Apolipoprotein D - Rattus norvegicus
BBP_PIEBR BILIN-BINDING PROTEIN PRECURSOR (BBP) - PIERIS BRASSICAE (WHITE BUTTERFLY).
CO8G_HUMAN COMPLEMENT COMPONENT C8 GAMMA CHAIN PRECURSOR - HOMO SAPIENS (HUMAN).
CRA2_HOMGA CRUSTACYANIN A2 SUBUNIT - HOMARUS GAMMARUS (EUROPEAN LOBSTER) (HOMARUS VULGARIS).
ERBP_RAT EPIDIDYMAL-RETINOIC ACID BINDING PROTEIN PRECURSOR (E-RABP) (ANDROGEN- DEPENDENT EPIDIDYMAL 18.5 KD PROTEIN) (EPIDIDYMAL SECRETORY PROTEIN I) (ESP-I) - RATTUS NORVEGICUS (RAT).
ESP4_LACVV EPIDIDYMAL SECRETORY PROTEIN IV PRECURSOR (LESP IV) (C731) - LACERTA VIVIPARA (COMMON LIZARD).
LACA_CANFA BETA-LACTOGLOBULIN I - CANIS FAMILIARIS (DOG).
LACA_EQUAS BETA-LACTOGLOBULIN II, MINOR MONOMERIC - EQUUS ASINUS (DONKEY).
LACA_FELCA BETA-LACTOGLOBULIN II - FELIS SILVESTRIS CATUS (CAT).
LACA_HORSE BETA-LACTOGLOBULIN II PRECURSOR, MINOR MONOMERIC (BLGII) - EQUUS CABALLUS (HORSE).
LACB_BOVIN BETA-LACTOGLOBULIN PRECURSOR (BETA-LG) (ALLERGEN BOS D 5) - BOS TAURUS (BOVINE).
LACB_BUBAR BETA-LACTOGLOBULIN - BUBALUS ARNEE BUBALIS (DOMESTIC WATER BUFFALO).
LACB_CAPHI BETA-LACTOGLOBULIN PRECURSOR - CAPRA HIRCUS (GOAT).
LACB_EQUAS BETA-LACTOGLOBULIN I, MAJOR MONOMERIC - EQUUS ASINUS (DONKEY).
LACB_FELCA BETA-LACTOGLOBULIN I - FELIS SILVESTRIS CATUS (CAT).
LACB_HORSE BETA-LACTOGLOBULIN I PRECURSOR (BLGI) - EQUUS CABALLUS (HORSE).
LACB_PIG BETA-LACTOGLOBULIN IA AND IC PRECURSOR - SUS SCROFA (PIG).
LACB_SHEEP BETA-LACTOGLOBULIN 1/B, 2/A, AND 3/C PRECURSOR - OVIS ARIES (SHEEP), AND OVIS ORIENTALIS MUSIMON (MOUFLON).
LACC_CANFA BETA-LACTOGLOBULIN III - CANIS FAMILIARIS (DOG).
LACC_FELCA BETA-LACTOGLOBULIN III - FELIS SILVESTRIS CATUS (CAT).
LIPO_BUFMA LIPOCALIN PRECURSOR - BUFO MARINUS (GIANT TOAD) (CANE TOAD).
MUP1_MOUSE MAJOR URINARY PROTEIN 1 PRECURSOR (MUP 1) - MUS MUSCULUS (MOUSE).
MUP2_MOUSE MAJOR URINARY PROTEIN 2 PRECURSOR (MUP 2) - MUS MUSCULUS (MOUSE).
MUP4_MOUSE MAJOR URINARY PROTEIN 4 PRECURSOR (MUP 4) - MUS MUSCULUS (MOUSE).
MUP5_MOUSE MAJOR URINARY PROTEIN 5 PRECURSOR (MUP 5) - MUS MUSCULUS (MOUSE).
MUP6_MOUSE MAJOR URINARY PROTEIN 6 PRECURSOR (MUP 6) (ALPHA-2U-GLOBULIN) (GROUP 1, BS6) (ALLERGEN MUS M 1) - MUS MUSCULUS (MOUSE).
MUPM_MOUSE MINOR MAJOR URINARY PROTEIN 15 PRECURSOR (NON-GROUP 1/GROUP 2 MUP15) (MUP3) - MUS MUSCULUS (MOUSE).
MUP_RAT MAJOR URINARY PROTEIN PRECURSOR (MUP) (ALPHA-2U-GLOBULIN) (15.5 KD FATTY ACID BINDING PROTEIN) (15.5 KD FABP) - RATTUS NORVEGICUS (RAT).
NGAL_HUMAN NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN PRECURSOR (NGAL) (P25) (25 KD ALPHA-2-MICROGLOBULIN-RELATED SUBUNIT OF MMP-9) (LIPOCALIN-2) (ONCOGENE 24P3) - HOMO SAPIENS (HUMAN).
NGAL_MOUSE NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN PRECURSOR (NGAL) (P25) (SV-40 INDUCED 24P3 PROTEIN) - MUS MUSCULUS (MOUSE).
NGAL_RAT NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN PRECURSOR (NGAL) (P25) (ALPHA-2-MICROGLOBULIN-RELATED PROTEIN) (ALPHA-2U GLOBULIN-RELATED PROTEIN) - RATTUS NORVEGICUS (RAT).
O62822 BETA-LACTOGLOBULIN - BUBALUS ARNEE BUBALIS (DOMESTIC WATER BUFFALO).
O70160 ALPHA-1-MICROGLOBULIN/BIKUNIN - CAVIA PORCELLUS (GUINEA PIG).
O88787 ME-RABP MINOR FORM PROTEIN - MUS MUSCULUS (MOUSE).
P70004 ALPHA1-MICROGLOBULIN/BIKUNIN PRECURSOR (AMBP) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
PGHD_BOVIN PROSTAGLANDIN-H2 D-ISOMERASE PRECURSOR (EC 5.3.99.2) (PROSTAGLANDIN-D SYNTHASE) (GLUTATHIONE-INDEPENDENT PGD SYNTHETASE) (PROSTAGLANDIN D2 SYNTHASE) (PGD2 SYNTHASE) (PGDS2) - BOS TAURUS (BOVINE).
PGHD_FELCA PROSTAGLANDIN-H2 D-ISOMERASE PRECURSOR (EC 5.3.99.2) (PROSTAGLANDIN-D SYNTHASE) (GLUTATHIONE-INDEPENDENT PGD SYNTHETASE) (PROSTAGLANDIN D2 SYNTHASE) (PGD2 SYNTHASE) (PGDS2) - FELIS SILVESTRIS CATUS (CAT).
PGHD_HUMAN PROSTAGLANDIN-H2 D-ISOMERASE PRECURSOR (EC 5.3.99.2) (PROSTAGLANDIN-D SYNTHASE) (GLUTATHIONE-INDEPENDENT PGD SYNTHETASE) (PROSTAGLANDIN D2 SYNTHASE) (PGD2 SYNTHASE) (PGDS2) (BETA-TRACE PROTEIN) - HOMO SAPIENS (HUMAN).
PGHD_MOUSE PROSTAGLANDIN-H2 D-ISOMERASE PRECURSOR (EC 5.3.99.2) (PROSTAGLANDIN-D SYNTHASE) (GLUTATHIONE-INDEPENDENT PGD SYNTHETASE) (PROSTAGLANDIN D2 SYNTHASE) (PGD2 SYNTHASE) (PGDS2) - MUS MUSCULUS (MOUSE).
PGHD_PIG PROSTAGLANDIN-H2 D-ISOMERASE PRECURSOR (EC 5.3.99.2) (PROSTAGLANDIN-D SYNTHASE) (GLUTATHIONE-INDEPENDENT PGD SYNTHETASE) (PROSTAGLANDIN D2 SYNTHASE) (PGD2 SYNTHASE) (PGDS2) - SUS SCROFA (PIG).
PGHD_RAT PROSTAGLANDIN-H2 D-ISOMERASE PRECURSOR (EC 5.3.99.2) (PROSTAGLANDIN-D SYNTHASE) (GLUTATHIONE-INDEPENDENT PGD SYNTHETASE) (PROSTAGLANDIN D2 SYNTHASE) (PGD2 SYNTHASE) (PGDS2) - RATTUS NORVEGICUS (RAT).
PGHD_URSAR PROSTAGLANDIN-H2 D-ISOMERASE PRECURSOR (EC 5.3.99.2) (PROSTAGLANDIN-D SYNTHASE) (GLUTATHIONE-INDEPENDENT PGD SYNTHETASE) (PROSTAGLANDIN D2 SYNTHASE) (PGD2 SYNTHASE) (PGDS2) - URSUS ARCTOS (BROWN BEAR) (GRIZZLY BEAR).
PP14_HUMAN PREGNANCY-ASSOCIATED ENDOMETRIAL ALPHA-2 GLOBULIN PRECURSOR (PEG) (PLACENTAL PROTEIN 14) (PROGESTAGEN-ASSOCIATED ENDOMETRIAL PROTEIN) - HOMO SAPIENS (HUMAN).
PURP_CHICK PURPURIN PRECURSOR - GALLUS GALLUS (CHICKEN).
Q00629 INSECTICYANIN A FORM (BLUE BILIPROTEIN) - MANDUCA SEXTA (TOBACCO HAWKMOTH) (TOBACCO HORNWORM).
Q24996 GALLERIN - GALLERIA MELLONELLA (WAX MOTH).
Q28369 RETINOL BINDING PROTEIN PRECURSOR - EQUUS CABALLUS (HORSE).
Q28679 COMPLEMENT COMPONENT C8 GAMMA SUBUNIT PRECURSOR - ORYCTOLAGUS CUNICULUS (RABBIT).
Q61921 MAJOR URINARY PROTEIN - MUS MUSCULUS (MOUSE).
Q63024 RAT ALPHA-2U-GLOBULIN (L TYPE) - RATTUS NORVEGICUS (RAT).
Q63025 RAT ALPHA-2U-GLOBULIN (S TYPE) - RATTUS NORVEGICUS (RAT).
Q63213 ALPHA-2U GLOBULIN (RAT SALIVARY GLAND (ALPHA)2(MU) GLOBULIN, TYPE 1) - RATTUS NORVEGICUS (RAT).
Q91721 CPL-1 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q92136 PROSTAGLANDIN D SYNTHASE (EC 5.3.99.2) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
QSP_CHICK QUIESCENCE-SPECIFIC PROTEIN PRECURSOR (P20K) (CH21 PROTEIN) - GALLUS GALLUS (CHICKEN).
RET1_ONCMY PLASMA RETINOL-BINDING PROTEIN I (PRBP-I) - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI).
RET2_ONCMY PLASMA RETINOL-BINDING PROTEIN II (PRBP-II) - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI).
RETB_BOVIN PLASMA RETINOL-BINDING PROTEIN (PRBP) (RBP) - BOS TAURUS (BOVINE).
RETB_CHICK PLASMA RETINOL-BINDING PROTEIN PRECURSOR (PRBP) - GALLUS GALLUS (CHICKEN).
RETB_HUMAN PLASMA RETINOL-BINDING PROTEIN PRECURSOR (PRBP) (RBP) - HOMO SAPIENS (HUMAN).
RETB_MOUSE PLASMA RETINOL-BINDING PROTEIN PRECURSOR (PRBP) (RBP) - MUS MUSCULUS (MOUSE).
RETB_PIG PLASMA RETINOL-BINDING PROTEIN PRECURSOR (PRBP) (RBP) - SUS SCROFA (PIG).
RETB_RABIT PLASMA RETINOL-BINDING PROTEIN PRECURSOR (PRBP) (RBP) - ORYCTOLAGUS CUNICULUS (RABBIT).
RETB_RAT PLASMA RETINOL-BINDING PROTEIN PRECURSOR (PRBP) (RBP) - RATTUS NORVEGICUS (RAT).
RETB_XENLA PLASMA RETINOL-BINDING PROTEIN PRECURSOR (PRBP) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).

A1AI_MOUSE ALPHA-1-ACID GLYCOPROTEIN 3 PRECURSOR (AGP 3) (OROSOMUCOID 3) (OMD 3) - MUS MUSCULUS (MOUSE).
ALL1_CANFA MAJOR ALLERGEN CAN F 1 PRECURSOR (ALLERGEN DOG 1) - CANIS FAMILIARIS (DOG).
ALL1_HORSE MAJOR ALLERGEN EQU C 1 PRECURSOR - EQUUS CABALLUS (HORSE).
APOD_CAVPO Apolipoprotein D - Cavia porcellus
BLC_ECOLI Outer membrane lipoprotein blc - Escherichia coli (strain K12)
BLC_VIBCH Outer membrane lipoprotein blc - Vibrio cholerae
CRC1_HOMGA CRUSTACYANIN C1 SUBUNIT - HOMARUS GAMMARUS (EUROPEAN LOBSTER) (HOMARUS VULGARIS).
ICYA_MANSE INSECTICYANIN A FORM (BLUE BILIPROTEIN) (INS-A) - MANDUCA SEXTA (TOBACCO HAWKMOTH) (TOBACCO HORNWORM).
ICYB_MANSE INSECTICYANIN B FORM PRECURSOR (BLUE BILIPROTEIN) (INS-B) - MANDUCA SEXTA (TOBACCO HAWKMOTH) (TOBACCO HORNWORM).
LAZA_SCHAM LAZARILLO PROTEIN PRECURSOR - SCHISTOCERCA AMERICANA (AMERICAN GRASSHOPPER).
O31025 OUTER MEMBRANE LIPOPROTEIN BLC PRECURSOR (PROTEIN VLP) - VIBRIO CHOLERAE.
O35091 PROSTAGLANDIN D SYNTHETASE - MUS MUSCULUS (MOUSE).
OLFA_RANPI OLFACTORY PROTEIN PRECURSOR - RANA PIPIENS (NORTHERN LEOPARD FROG).
Q28388 P19 LIPOCALIN - EQUUS CABALLUS (HORSE).
VEG1_RAT VON EBNER'S GLAND PROTEIN 1 PRECURSOR (VEG PROTEIN 1) - RATTUS NORVEGICUS (RAT).
VEG2_RAT VON EBNER'S GLAND PROTEIN 2 PRECURSOR (VEG PROTEIN 2) - RATTUS NORVEGICUS (RAT).
VEGP_HUMAN VON EBNER'S GLAND PROTEIN PRECURSOR (VEG PROTEIN) (TEAR PREALBUMIN) (TP) (TEAR LIPOCALIN) (LIPOCALIN-1) - HOMO SAPIENS (HUMAN).
VEGP_PIG VON EBNER'S GLAND PROTEIN PRECURSOR (VEG PROTEIN) (TEAR PREALBUMIN) (TP) (TEAR LIPOCALIN) (LIPOCALIN-1) - SUS SCROFA (PIG).
VNS1_MOUSE VESOMERAL SECRETORY PROTEIN I PRECURSOR (VNSP I) - MUS MUSCULUS (MOUSE).
Scan History
OWL11_1    5  500  NSINGLE    
OWL17_1 1 260 NSINGLE
OWL18_0 1 300 NSINGLE
OWL19_0 2 790 NSINGLE
OWL19_1 1 790 NSINGLE
OWL21_0 1 800 NSINGLE
OWL25_2 1 710 NSINGLE
OWL26_0 1 750 NSINGLE
SPTR37_9f 1 300 NSINGLE
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
QKVAGTWYSLAMA LACB_BUBAR 13 13 -
EQISGYWFSIAEA MUPM_MOUSE 35 35 -
ARFSGTWYAMAKK RETB_HUMAN 34 34 -
NKYLGRWYEIEKI APOD_HUMAN 40 40 -
SNYHGKWWEVAKY BBP_PIEBR 35 35 -
SRIYGKWYNLAIG AMBP_HUMAN 38 38 -

Motif 2 width=13
Element Seqn Id St Int Rpt
ILKTDYDNYIMIH MUPM_MOUSE 114 66 -
IVDTDYDTYAVQY RETB_HUMAN 122 75 -
ILATDYENYALVY APOD_HUMAN 120 67 -
VLSTDNKNYIIGY BBP_PIEBR 116 68 -
VVHTNYDEYAIFL AMBP_HUMAN 121 71 -
VLDTDYKKYLLFC LACB_BUBAR 94 68 -

Motif 3 width=16
Element Seqn Id St Int Rpt
VFSRDPNGLPPEAQKI RETB_HUMAN 152 17 -
ILARNPNLPPETVDSL APOD_HUMAN 148 15 -
VLSRSKVLTGEAKTAV BBP_PIEBR 145 16 -
LYGRAPQLRETLLQDF AMBP_HUMAN 150 15 -
CLVRTPEVDDEALEKF LACB_BUBAR 139 14 -
LYGREPDLSLDIKEKF MUPM_MOUSE 141 14 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
QKVAGTWHSMAMA LACA_CANFA 13 13 -
EQISGYWFSIAEA MUPM_MOUSE 35 35 -
ARFSGTWYAMAKK RETB_HUMAN 34 34 -
AKLNGDWFSIVVA MUP_RAT 32 32 -
DKLNGDWFSIVVA Q63024 32 32 -
DKLNGDWFSIVVA Q63025 32 32 -
DKFLGRWYSAGLA PGHD_RAT 37 37 -
QKVAGTWHSMAMA LACC_FELCA 13 13 -
DKFLGRWFSAGLA PGHD_HUMAN 37 37 -
EKINGEWFSILLA MUP4_MOUSE 29 29 -
QKVAGTWYSLAMA O62822 31 31 -
NRYSGTWYAMAKK RETB_CHICK 39 39 -
ARFSGTWYAMAKK RETB_PIG 36 36 -
QKVAGMWHSMAMA LACB_FELCA 13 13 -
QKVAGTWHSMAMA LACC_CANFA 13 13 -
SKFLGFWYEIAFA ERBP_RAT 31 31 -
ARFAGTWYAMAKK RETB_RABIT 36 36 -
ARFSGTWYAMAKK Q28369 36 36 -
SRYTGRWYAVAKK RET2_ONCMY 17 17 -
SRYTGRWYAVAKK RET1_ONCMY 17 17 -
KRYAGKWYALAKK PURP_CHICK 38 38 -
QEVAGKWHSVAMA LACB_HORSE 31 31 -
SEVAGKWYIVALA QSP_CHICK 28 28 -
ARFAGTWYAMAKK RETB_BOVIN 18 18 -
EKINGEWHTIILA MUP1_MOUSE 31 31 -
EKINGEWHTIILA Q61921 29 29 -
EKINGEWHTIILA MUP2_MOUSE 31 31 -
EKVLGKWYGIGLA Q91721 32 32 -
EKVLGKWYGIGLA Q92136 32 32 -
ERFQGRWFVVGLA NGAL_RAT 45 45 -
SAFAGAWHEIAKL Q00629 38 38 -
RQVAGTWHSMAMA LACA_FELCA 13 13 -
DKFLGRWFTSGLA PGHD_FELCA 37 37 -
EKINGEWHTIILA MUP6_MOUSE 31 31 -
ARFSGLWYAIAKK RETB_MOUSE 36 36 -
QEVAGRWHSVAMV LACA_EQUAS 13 13 -
QEVAGRWHSVAMV LACA_HORSE 31 31 -
DKFLGRWFTSGLA PGHD_URSAR 37 37 -
ERYAGVWYAVAKK RETB_XENLA 38 38 -
QKVAGTWHTVAMA LACB_PIG 31 31 -
DKFLGRWYSAGLA PGHD_MOUSE 37 37 -
ARFSGLWYAIAKK RETB_RAT 36 36 -
DQFRGRWYVVGLA NGAL_MOUSE 45 45 -
QEVAGKWHSVAMA LACB_EQUAS 13 13 -
NKYLGRWYEIEKI APOD_HUMAN 40 40 -
KKYLGRWYEIEKI APOD_MOUSE 40 40 -
PKLAGTWHSMAMA PP14_HUMAN 31 31 -
HKYLGRWYEIEKI APOD_RABIT 41 41 -
KKYLGRWYEIEKI APOD_RAT 40 40 -
DKFLGRWFTSGLA PGHD_BOVIN 37 37 -
NKFLGFWYEIALA O88787 10 10 -
SNYHGKWWEVAKY BBP_PIEBR 35 35 -
NQFQGKWYVVGLA NGAL_HUMAN 45 45 -
DKILGKWYGIGLA LIPO_BUFMA 31 31 -
SRMYGKWYSLAIG O70160 38 38 -
DKFLGRWFTSGLA PGHD_PIG 35 35 -
QQFAGTWLLVAVG CO8G_HUMAN 45 45 -
RRYAGRWYQTHII CRA2_HOMGA 24 24 -
QKTVGKWHPIGMA ESP4_LACVV 32 32 -
TAYQGVWYEISKT Q24996 35 35 -
QRIYGKWYDIAIG P70004 37 37 -
QQFAGTWLLAAVG Q28679 45 45 -
ARIYGKWFNLAVG AMBP_RAT 37 37 -
SRIYGKWFNLAVG AMBP_MESAU 37 37 -
SRIYGKWYNLAVG AMBP_MOUSE 37 37 -
SLIYGKWFNLAVG AMBP_MERUN 37 37 -
SRIYGKWYNLAIG AMBP_HUMAN 38 38 -
SRIYGKWFNVAVG AMBP_BOVIN 38 38 -
QKVAGTWYSLAMA LACB_BUBAR 13 13 -
QKVAGTWYSLAMA LACB_BOVIN 29 29 -
QKVAGTWYSLAMA LACB_CAPHI 31 31 -
EKINGKWFSILLA MUP5_MOUSE 31 31 -
QKVAGTWHSLAMA LACB_SHEEP 31 31 -
DKLNGDWFSIVVA Q63213 32 32 -

Motif 2 width=13
Element Seqn Id St Int Rpt
ILKTDYDNYIMFH MUP4_MOUSE 108 66 -
VLDTDYKKYLLFC O62822 112 68 -
VLDTDYKKYLLFC LACB_BUBAR 94 68 -
VLDTDYKKYLLFC LACB_BOVIN 110 68 -
VLDTDYKKYLLFC LACB_CAPHI 112 68 -
ILKTDYDNYIMFH MUP5_MOUSE 110 66 -
VLDTDYKKYLLFC LACB_SHEEP 112 68 -
ILKTDYDNYVMFH Q63213 111 66 -
LLDTDYDNYLFFC LACA_CANFA 94 68 -
ILKTDYDNYIMIH MUPM_MOUSE 114 66 -
IVDTDYDTYAVQY RETB_HUMAN 122 75 -
ILKTDYDRYVMFH MUP_RAT 111 66 -
ILKTDYDRYVMFH Q63024 111 66 -
ILKTDYDRYVMFH Q63025 111 66 -
VVETDYDEYAFLF PGHD_RAT 120 70 -
VLDTDYENYLFFC LACC_FELCA 94 68 -
VVETDYDQYALLY PGHD_HUMAN 120 70 -
VVDTDYDTYALHY RETB_CHICK 127 75 -
IIDTDYDTYAVQY RETB_PIG 124 75 -
VLDTDYENYLFFC LACB_FELCA 94 68 -
LLDTDYDNYLFFC LACC_CANFA 94 68 -
VEATDYLTYAIID ERBP_RAT 111 67 -
IIDTDYDTFAVQY RETB_RABIT 124 75 -
IIDTDYDTYAVQY Q28369 124 75 -
VIDTDYDNYAIHY RET2_ONCMY 105 75 -
VIDTDYDNYAIHY RET1_ONCMY 105 75 -
VIDTDYDNYAITY PURP_CHICK 128 77 -
ALDTDYKNYLFLC LACB_HORSE 112 68 -
VLDTDYKSYAVIF QSP_CHICK 108 67 -
IIDTDYETFAVQY RETB_BOVIN 106 75 -
IPKTDYDNFLMAH MUP1_MOUSE 110 66 -
IPKTDYDNFLMAH Q61921 108 66 -
IPKTDYDNFLMAH MUP2_MOUSE 110 66 -
VVETNYDEYILMY Q91721 115 70 -
VVETNYDEYILMY Q92136 115 70 -
VADTDYDQFAMVF NGAL_RAT 130 72 -
VLATDYKNYAINY Q00629 122 71 -
VLDTDYTHYMFFC LACA_FELCA 94 68 -
VVATDYEEYALLY PGHD_FELCA 120 70 -
IPKTDYDNFLMAH MUP6_MOUSE 110 66 -
IIDTDYDTFALQY RETB_MOUSE 124 75 -
VLDTDYAHYMFFC LACA_EQUAS 94 68 -
VLDTDYAHYMFFC LACA_HORSE 112 68 -
VAMTDYDEYALLY PGHD_URSAR 120 70 -
VVDTDYTTYAITY RETB_XENLA 126 75 -
LLDTDYDSHLLLC LACB_PIG 112 68 -
VVEANYDEYALLF PGHD_MOUSE 120 70 -
IIDTDYDTFALQY RETB_RAT 124 75 -
VATTDYNQFAMVF NGAL_MOUSE 132 74 -
ALDSDYKNYLFLC LACB_EQUAS 94 68 -
ILATDYENYALVY APOD_HUMAN 120 67 -
ILATDYENYALVY APOD_MOUSE 120 67 -
LLDTDYDNFLFLC PP14_HUMAN 112 68 -
VLATDYENYALVY APOD_RABIT 121 67 -
ILATDYESYALVY APOD_RAT 120 67 -
VAETDYETYALLY PGHD_BOVIN 120 70 -
VVATDYMTYTVID O88787 90 67 -
VLSTDNKNYIIGY BBP_PIEBR 116 68 -
VVSTNYNQHAMVF NGAL_HUMAN 130 72 -
VVESNYDEYTLMH LIPO_BUFMA 114 70 -
VVHTNYDEYATVL O70160 122 71 -
VVETDYKNYALLH PGHD_PIG 118 70 -
VAETDYQSFAVLY CO8G_HUMAN 127 69 -
VIETDYETYSCVY CRA2_HOMGA 105 68 -
MMDIDYEKYLIMY ESP4_LACVV 107 62 -
VIATDYQNYAIAY Q24996 117 69 -
IVFTNYNEYVIMQ P70004 121 71 -
AAETDYHSFAVLY Q28679 127 69 -
VVHTNYDEYAIFL AMBP_BOVIN 122 71 -
VVHTNYDEYAIFL AMBP_HUMAN 121 71 -
VVHTNYDEYAIFL AMBP_MERUN 121 71 -
VVHTNYDEYAIFL AMBP_MOUSE 121 71 -
VVHTNYDEYAIFL AMBP_MESAU 121 71 -
VVHTNYDEYAIFL AMBP_RAT 121 71 -

Motif 3 width=16
Element Seqn Id St Int Rpt
LYGRTKDLSSDIKEKF Q63025 138 14 -
LYSRAQLLKEELKEKF PGHD_RAT 148 15 -
CLTRTLKADNEVMEKF LACC_FELCA 121 14 -
LYSRTQTPRAELKEKF PGHD_HUMAN 148 15 -
LYGRKADLNSDIKEKF MUP4_MOUSE 135 14 -
VFSRDPKGLPPEAQKI RETB_CHICK 157 17 -
VFARDPHGFSPEVQKI RETB_PIG 154 17 -
CLTRTLKADNEVMEKF LACB_FELCA 121 14 -
CLARTLEVNNEVIGKF LACC_CANFA 121 14 -
LYSRSLDDNGEALYNF ERBP_RAT 138 14 -
VFSRDPHGLPPDVQKL RETB_RABIT 154 17 -
VFARDPNGFPPEVQRI Q28369 154 17 -
IFSRHPTGLRPEDQKI RET2_ONCMY 135 17 -
IFSRHPTGLRPEDQKI RET1_ONCMY 135 17 -
IFSRNPRGLPPAIQRI PURP_CHICK 158 17 -
YLARTQMVDEEIMEKF LACB_HORSE 139 14 -
LYSRSREVSPTAMAIF QSP_CHICK 135 14 -
VFARDPSGFSPEVQKI RETB_BOVIN 136 17 -
LYGREPDLSSDIKERF MUP1_MOUSE 137 14 -
LYGREPDLSSDIKERF Q61921 135 14 -
LYGREPDLSSDIKERF MUP2_MOUSE 137 14 -
LFGRDKDLRPELLDKF Q91721 142 14 -
LFGRDKDLRPELLDKF Q92136 142 14 -
LYGRTKGLSDELKERF NGAL_RAT 157 14 -
VLSRNKVLEGNTKEVV Q00629 151 16 -
YLARTLKADNEVMEKF LACA_FELCA 122 15 -
LYSRTQTPRAEVKEKF PGHD_FELCA 148 15 -
LYGREPDLMSDIKERF MUP6_MOUSE 137 14 -
VFSRDPNGLSPETRRL RETB_MOUSE 154 17 -
YLARTQKVDEEVMEKF LACA_EQUAS 122 15 -
YLARTQKVDEEVMEKF LACA_HORSE 140 15 -
LYSRTQTPRAEIKEKF PGHD_URSAR 148 15 -
VFSRDINGLPSESQRI RETB_XENLA 156 17 -
SLARTLEVDDQIREKF LACB_PIG 139 14 -
LYSRTQTLKDELKEKF PGHD_MOUSE 148 15 -
VFSRDPNGLTPETRRL RETB_RAT 154 17 -
LYGRTKELSPELKERF NGAL_MOUSE 159 14 -
YLARTQMVDEEIMEKF LACB_EQUAS 121 14 -
ILARNPNLPPETVDSL APOD_HUMAN 148 15 -
ILGRNPYLPPETITYL APOD_MOUSE 148 15 -
YLARVLVEDDEIMQGF PP14_HUMAN 139 14 -
ILGRNRYLPPETVTYL APOD_RABIT 149 15 -
ILGRNPYLPPETITYL APOD_RAT 148 15 -
LYSRSQNPRAEVKEHF PGHD_BOVIN 148 15 -
LYSRSLDNNGEALNNF O88787 117 14 -
VLSRSKVLTGEAKTAV BBP_PIEBR 145 16 -
LYGRTKELTSELKENF NGAL_HUMAN 157 14 -
LFGRRKTLSPELLDKF LIPO_BUFMA 141 14 -
LYGREPQLRDSLLQGF O70160 150 15 -
LYSRSQAPGAAVREKF PGHD_PIG 146 15 -
LYARSLPVSDSVLSGF CO8G_HUMAN 150 10 -
VFSRTPQTSGPAVEKT CRA2_HOMGA 132 14 -
LSARGSDVGDDIKEKF ESP4_LACVV 130 10 -
ILSRAKKLEGDAKTAV Q24996 146 16 -
LYGRSPDLRPTLVDEF P70004 148 14 -
LYVRSLPVSDSVLGAF Q28679 150 10 -
LYGREPQLRESLLEEF AMBP_BOVIN 150 15 -
LYGREPQLRDSLLQEF AMBP_MESAU 149 15 -
CLVRTPEVDNEALEKF LACB_SHEEP 139 14 -
LYGRAPQLRETLLQDF AMBP_HUMAN 150 15 -
CLVRTPEVDDEALEKF O62822 139 14 -
LFGREPDLSSDIKEKF MUP5_MOUSE 137 14 -
LYGREPKLRDSLLLEF AMBP_MERUN 149 15 -
CLVRTPEVDDEALEKF LACB_BUBAR 139 14 -
CLVRTPEVDKEALEKF LACB_CAPHI 139 14 -
LYGREPQLRDSLLQEF AMBP_MOUSE 149 15 -
LYGREPQLRDSLLQEF AMBP_RAT 149 15 -
CLVRTPEVDDEALEKF LACB_BOVIN 137 14 -
LYGRTKDLSSDIKEKF Q63213 138 14 -
CLARTLEVDNEVMEKF LACA_CANFA 121 14 -
LYGREPDLSLDIKEKF MUPM_MOUSE 141 14 -
VFSRDPNGLPPEAQKI RETB_HUMAN 152 17 -
LYGRTKDLSSDIKEKF MUP_RAT 138 14 -
LYGRTKDLSSDIKEKF Q63024 138 14 -