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PR00173

Identifier
EDTRNSPORT  [View Relations]  [View Alignment]  
Accession
PR00173
No. of Motifs
9
Creation Date
10-FEB-1994  (UPDATE 25-JUN-1999)
Title
Glutamate-aspartate symporter signature
Database References

PROSITE; PS00713 NA_DICARBOXYL_SYMP_1; PS00714 NA_DICARBOXYL_SYMP_2
PFAM; PF00375 SDF
INTERPRO; IPR001991
Literature References
1. PINES, G., DANBOLT, N.C., BJORASS, M., ZHANG, Y.M., BENDAHAN, A., EIDE,
L., KOEPSELL, H., STORMMATHISEN, J., SEEBERG, E. AND KANNER, B.I.
Cloning and expression of a rat brain L-glutamate transporter.
NATURE 360 464-467 (1992).
 
2. KANAI, Y. AND HEDIGER, M.A.
Primary structure and functional characterization of a high affinity
glutamate transporter.
NATURE 360 467-471 (1992).
 
3. TOLNER, B., POOLMAN, B. AND KONINGS, W.N.
Characterization and functional expression in Escherichia coli of the sodium
proton glutamate symport proteins of Bacillus stearothermophilus and Bacillus
caldotenax.
MOL.MICROBIOL. 6(19) 2845-2856 (1992).

Documentation
Synaptic transmission in vertebrates is thought to be terminated by 
rapid transport of the neurotransmitter from the synaptic cleft into 
presynaptic nerve terminals, or neuroglia, before it can reach neurotoxic
levels [1,2]. L-Glutamate, the main excitory transmitter in the brain,
is removed by a stereo-specific transporter that imports both sodium
ions and L-glutamate, and exports potassium ions [1]: it is inhibited by
D-glutamate and high extracellular potassium ion concentration [2].
 
The structure of the transporter protein has been variously reported to
contain from 8 to 10 transmembrane (TM) regions, although 10 now seems to
be the accepted value. Abnormal neurotransmitter transport occurs in some
neurodegenerative diseases (anoxia and ischaemia), and this may reflect
problems with the transporter protein itself [2]. Bacteria have several
different L-glutamate transport systems, one of which uses a protein
similar to the vertebrate brain L-glutamate transporter, greatest
conservation occurring in the TM regions [3]. Both vertebrate brain and
bacterial L-glutamate transporters can also transport L-aspartate.
 
EDTRNSPORT is a 9-element fingerprint that provides a signature for the
glutamate-aspartate transporters. The fingerprint was derived from an
initial alignment of 3 sequences: motifs 1-6 encode the first six TM
regions, and motifs 7-9 encode the final three (TM domain 7 was not
sufficiently well-conserved to be included in the fingerprint) - motifs 3
and 7 include regions encoded by PROSITE patterns NA_DICARBOXYL_SYMP_1
(PS00713) and NA_DICARBOXYL_SYMP_2 (PS00714). Three iterations on OWL22.1
were required to reach convergence, at which point a true set comprising
10 sequences was identified. Three partial matches were also found,
DCTA_RHILE, DCTA_RHIME and DCTA_RHISN, which are members of the sodium
dicarboxylate symporter superfamily of which the glutamate-aspartate
transporters are members.
 
An update on SPTR37_9f identified a true set of 37 sequences, and 18
partial matches.
Summary Information
  37 codes involving  9 elements
3 codes involving 8 elements
2 codes involving 7 elements
1 codes involving 6 elements
4 codes involving 5 elements
2 codes involving 4 elements
4 codes involving 3 elements
2 codes involving 2 elements
Composite Feature Index
9373737373737373737
8333330333
7022211222
6011100111
5044400431
4022000220
3041010231
2010010101
123456789
True Positives
AAAT_HUMAN    AAAT_RABIT    AAAX_MOUSE    EAT1_BOVIN    
EAT1_CAEEL EAT1_HUMAN EAT1_MOUSE EAT1_RAT
EAT2_CAEEL EAT2_HUMAN EAT2_MOUSE EAT2_RAT
EAT3_BOVIN EAT3_CAEEL EAT3_HUMAN EAT3_MOUSE
EAT3_RABIT EAT3_RAT EAT4_CAEEL EAT4_HUMAN
EAT4_MOUSE EAT4_RAT EAT5_HUMAN EAT_ONCVO
GLTP_ECOLI O16016 O18210 O54686
O54687 O57321 O57322 O57323
O57324 O57325 O77062 SATT_HUMAN
SATT_MOUSE
True Positive Partials
Codes involving 8 elements
GLTT_BACCA GLTT_BACST O07605
Codes involving 7 elements
O59010 O67349
Codes involving 6 elements
O84406
Codes involving 5 elements
DCTA_ECOLI DCTA_SALTY GLTP_BACSU P96603
Codes involving 4 elements
DCTA_RHILE DCTA_RHIME
Codes involving 3 elements
DCTA_RHISN P71906 P77529 Q54104
Codes involving 2 elements
YB54_HAEIN YGJU_ECOLI
Sequence Titles
AAAT_HUMAN  NEUTRAL AMINO ACID TRANSPORTER B(0) (ATB(0)) - HOMO SAPIENS (HUMAN). 
AAAT_RABIT NEUTRAL AMINO ACID TRANSPORTER B(0) (ATB(0)) - ORYCTOLAGUS CUNICULUS (RABBIT).
AAAX_MOUSE NEUTRAL AMINO ACID TRANSPORTER B (INSULIN-ACTIVATED AMINO ACID TRANSPORTER) (ASC-LIKE NA+ DEPENDENT NEUTRAL AMINO ACID TRANSPORTER ASCT2) - MUS MUSCULUS (MOUSE).
EAT1_BOVIN EXCITATORY AMINO ACID TRANSPORTER 1 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER 1) (GLAST1) - BOS TAURUS (BOVINE).
EAT1_CAEEL EXCITATORY AMINO ACID TRANSPORTER (SODIUM-DEPENDENT GLUTAMATE/ ASPARTATE TRANSPORTER) - CAENORHABDITIS ELEGANS.
EAT1_HUMAN EXCITATORY AMINO ACID TRANSPORTER 1 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER 1) (GLIAL GLUTAMATE TRANSPORTER) (GLAST1) - HOMO SAPIENS (HUMAN).
EAT1_MOUSE EXCITATORY AMINO ACID TRANSPORTER 1 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER) (HIGH-AFFINITY NEURONAL GLUTAMATE TRANSPORTER) (GLIAL HIGH AFFINITY GLUTAMATE TRANSPORTER) (GLAST) - MUS MUSCULUS (MOUSE).
EAT1_RAT EXCITATORY AMINO ACID TRANSPORTER 1 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER 1) (GLAST) - RATTUS NORVEGICUS (RAT).
EAT2_CAEEL PUTATIVE SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER K08F4.4 - CAENORHABDITIS ELEGANS.
EAT2_HUMAN EXCITATORY AMINO ACID TRANSPORTER 2 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER 2) - HOMO SAPIENS (HUMAN).
EAT2_MOUSE EXCITATORY AMINO ACID TRANSPORTER 2 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER 2) - MUS MUSCULUS (MOUSE).
EAT2_RAT EXCITATORY AMINO ACID TRANSPORTER 2 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER 2) (GLUT-R) (GLT-1) - RATTUS NORVEGICUS (RAT).
EAT3_BOVIN EXCITATORY AMINO ACID TRANSPORTER 3 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER 3) (EXCITATORY AMINO-ACID CARRIER 1) (RENAL HIGH AFFINITY GLUTAMATE TRANSPORTER EAAC1) - BOS TAURUS (BOVINE).
EAT3_CAEEL PUTATIVE SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER R05G6.6 - CAENORHABDITIS ELEGANS.
EAT3_HUMAN EXCITATORY AMINO ACID TRANSPORTER 3 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER 3) (EXCITATORY AMINO-ACID CARRIER 1) - HOMO SAPIENS (HUMAN).
EAT3_MOUSE EXCITATORY AMINO ACID TRANSPORTER 3 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER 3) (EXCITATORY AMINO-ACID CARRIER 1) - MUS MUSCULUS (MOUSE).
EAT3_RABIT EXCITATORY AMINO ACID TRANSPORTER 3 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER 3) (EXCITATORY AMINO-ACID CARRIER 1) - ORYCTOLAGUS CUNICULUS (RABBIT).
EAT3_RAT EXCITATORY AMINO ACID TRANSPORTER 3 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER 3) (EXCITATORY AMINO-ACID CARRIER 1) - RATTUS NORVEGICUS (RAT).
EAT4_CAEEL PUTATIVE SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER T22E5.2 - CAENORHABDITIS ELEGANS.
EAT4_HUMAN EXCITATORY AMINO ACID TRANSPORTER 4 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER) - HOMO SAPIENS (HUMAN).
EAT4_MOUSE EXCITATORY AMINO ACID TRANSPORTER 4 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER) (HIGH-AFFINITY NEURONAL GLUTAMATE TRANSPORTER) - MUS MUSCULUS (MOUSE).
EAT4_RAT EXCITATORY AMINO ACID TRANSPORTER 4 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER) (HIGH-AFFINITY NEURONAL GLUTAMATE TRANSPORTER) - RATTUS NORVEGICUS (RAT).
EAT5_HUMAN EXCITATORY AMINO ACID TRANSPORTER 5 (RETINAL GLUTAMATE TRANSPORTER) - HOMO SAPIENS (HUMAN).
EAT_ONCVO EXCITATORY AMINO ACID TRANSPORTER (SODIUM-DEPENDENT GLUTAMATE/ ASPARTATE TRANSPORTER) - ONCHOCERCA VOLVULUS.
GLTP_ECOLI PROTON GLUTAMATE SYMPORT PROTEIN (GLUTAMATE-ASPARTATE CARRIER PROTEIN) - ESCHERICHIA COLI.
O16016 HIGH-AFFINITY NA+-DEPENDENT GLUTAMATE TRANSPORTER - TRICHOPLUSIA NI (CABBAGE LOOPER).
O18210 Y53C12A.2 PROTEIN - CAENORHABDITIS ELEGANS.
O54686 SOLUTE CARRIER FAMILY 1, MEMBER 2 (MGLT-1A) (MGLT-1B) - MUS MUSCULUS (MOUSE).
O54687 SOLUTE CARRIER FAMILY 1, MEMBER 2 (MGLT-1A) (MGLT-1B) - MUS MUSCULUS (MOUSE).
O57321 GLUTAMATE TRANSPORTER 1 - AMBYSTOMA TIGRINUM (TIGER SALAMANDER).
O57322 GLUTAMATE TRANSPORTER 2A - AMBYSTOMA TIGRINUM (TIGER SALAMANDER).
O57323 GLUTAMATE TRANSPORTER 2B - AMBYSTOMA TIGRINUM (TIGER SALAMANDER).
O57324 GLUTAMATE TRANSPORTER 5A - AMBYSTOMA TIGRINUM (TIGER SALAMANDER).
O57325 GLUTAMATE TRANSPORTER 5B - AMBYSTOMA TIGRINUM (TIGER SALAMANDER).
O77062 SODIUM-DEPENDENT GLUTAMATE TRANSPORTER - DROSOPHILA MELANOGASTER (FRUIT FLY).
SATT_HUMAN NEUTRAL AMINO ACID TRANSPORTER A (SATT) (ALANINE/SERINE/CYSTEINE/ THREONINE TRANSPORTER) (ASCT1) - HOMO SAPIENS (HUMAN).
SATT_MOUSE NEUTRAL AMINO ACID TRANSPORTER A (SATT) (ALANINE/SERINE/CYSTEINE/ THREONINE TRANSPORTER) (ASCT1) - MUS MUSCULUS (MOUSE).

GLTT_BACCA PROTON/SODIUM-GLUTAMATE SYMPORT PROTEIN (GLUTAMATE-ASPARTATE CARRIER PROTEIN) - BACILLUS CALDOTENAX.
GLTT_BACST PROTON/SODIUM-GLUTAMATE SYMPORT PROTEIN (GLUTAMATE-ASPARTATE CARRIER PROTEIN) - BACILLUS STEAROTHERMOPHILUS.
O07605 HYPOTHETICAL 45.9 KD PROTEIN - BACILLUS SUBTILIS.

O59010 425AA LONG HYPOTHETICAL PROTON GLUTAMATE SYMPORT PROTEIN - PYROCOCCUS HORIKOSHII.
O67349 PROTON/SODIUM-GLUTAMATE SYMPORT PROTEIN - AQUIFEX AEOLICUS.

O84406 GLUTAMATE SYMPORT - CHLAMYDIA TRACHOMATIS.

DCTA_ECOLI C4-DICARBOXYLATE TRANSPORT PROTEIN - ESCHERICHIA COLI.
DCTA_SALTY C4-DICARBOXYLATE TRANSPORT PROTEIN - SALMONELLA TYPHIMURIUM.
GLTP_BACSU PROTON GLUTAMATE SYMPORT PROTEIN (GLUTAMATE-ASPARTATE CARRIER PROTEIN) - BACILLUS SUBTILIS.
P96603 PROBABLE C4-DICARBOXYLATE TRANSPORT PROTEIN - BACILLUS SUBTILIS.

DCTA_RHILE C4-DICARBOXYLATE TRANSPORT PROTEIN - RHIZOBIUM LEGUMINOSARUM.
DCTA_RHIME C4-DICARBOXYLATE TRANSPORT PROTEIN - RHIZOBIUM MELILOTI.

DCTA_RHISN C4-DICARBOXYLATE TRANSPORT PROTEIN - RHIZOBIUM SP. (STRAIN NGR234).
P71906 HYPOTHETICAL 51.0 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
P77529 FROM BASES 1808117 TO 1819307 (SECTION 158 OF 400) OF THE COMPLETE GENOME (SECTION 158 OF 400) - ESCHERICHIA COLI.
Q54104 SIMILAR TO GLTP GLUTAMATE TRANSPORTERS - SACCHAROPOLYSPORA ERYTHRAEA (STREPTOMYCES ERYTHRAEUS).

YB54_HAEIN HYPOTHETICAL SYMPORTER HI1154 - HAEMOPHILUS INFLUENZAE.
YGJU_ECOLI HYPOTHETICAL 43.5 KD PROTEIN IN EBGC-UXAA INTERGENIC REGION (O414) - ESCHERICHIA COLI.
Scan History
OWL22_1    3  100  NSINGLE    
OWL26_0 1 100 NSINGLE
SPTR37_9f 2 100 NSINGLE
Initial Motifs
Motif 1  width=21
Element Seqn Id St Int Rpt
NWLLLSTVVAVVLGIVIGVLV GLTE_RABIT 18 18 -
NAFVLLTVSAVIVGTILGFAL GLTP_RAT 48 48 -
IGLAWQIFIGLILGIIVGAIF GLTT_BACCA 4 4 -

Motif 2 width=21
Element Seqn Id St Int Rpt
MLKLVILPLIVSSMITGVAAL GLTE_RABIT 62 23 -
MLQMLVLPLIISSLVTGMAAL GLTP_RAT 91 22 -
LIKMIVIPIVISSLVVGVASV GLTT_BACCA 44 19 -

Motif 3 width=26
Element Seqn Id St Int Rpt
GLRAVLYYFCTTIIAVILGIVLVVSI GLTE_RABIT 91 8 -
GMRAVVYYMTTTIIAVVIGIIIVIII GLTP_RAT 120 8 -
GGKTIIYFEIITTIAIVVGLLAANIF GLTT_BACCA 74 9 -

Motif 4 width=23
Element Seqn Id St Int Rpt
SDGINVLGLIVFCLVFGLVIGKM GLTE_RABIT 207 90 -
VNGVNALGLVVFSMCFGFVIGNM GLTP_RAT 238 92 -
LSTGDMLPIIFFSVMFGLGVAAI GLTT_BACCA 146 46 -

Motif 5 width=20
Element Seqn Id St Int Rpt
IMCYMPLGILFLIAGKIIEV GLTE_RABIT 254 24 -
IMWYAPLGILFLIAGKILEM GLTP_RAT 285 24 -
IMKFAPFGVFALIGVTVSKF GLTT_BACCA 193 24 -

Motif 6 width=20
Element Seqn Id St Int Rpt
LSGLAIHSIVILPLIYFIVV GLTE_RABIT 290 16 -
IVGLLIHAVIVLPLLYFLVT GLTP_RAT 322 17 -
LIPLSKLVIVVYATMLFFIF GLTT_BACCA 217 4 -

Motif 7 width=27
Element Seqn Id St Int Rpt
FVLPVGATINMDGTALYEAVAAVFIAQ GLTE_RABIT 357 47 -
FVLPVGATINMDGTALYEALAAIFIAQ GLTP_RAT 389 47 -
FVIPTGYSFNLDGSTLYQALAAIFIAQ GLTT_BACCA 293 56 -

Motif 8 width=20
Element Seqn Id St Int Rpt
GQIITISVTATAASIGAAGV GLTE_RABIT 392 8 -
GQIITISITATAASIGAAGI GLTP_RAT 424 8 -
SQQISLLLVLMVTSKGIAGV GLTT_BACCA 328 8 -

Motif 9 width=21
Element Seqn Id St Int Rpt
MVIVLSAVGLPAEDVTLIIAV GLTE_RABIT 419 7 -
MVIVLTSVGLPTDDITLIIAV GLTP_RAT 451 7 -
LLATLGTVGIPVEGLAFIAGI GLTT_BACCA 355 7 -
Final Motifs
Motif 1  width=21
Element Seqn Id St Int Rpt
NAFVLLTVSAVIVGTILGFAL EAT1_RAT 48 48 -
NAFVLLTVTAVIVGTILGFAL EAT1_MOUSE 48 48 -
NAFVLLTVTAVIVGTILGFTL EAT1_BOVIN 48 48 -
NAFVLLTVTAVIVGTILGFTL EAT1_HUMAN 48 48 -
NLLLSLTVFGVILGAVCGGLL EAT2_MOUSE 44 44 -
NLLLSLTVFGVILGAVCGGLL EAT2_RAT 44 44 -
NLLLSLTVFGVILGAVCGGLL O54686 41 41 -
NLLLSLTVFGVILGAVCGGLL O54687 41 41 -
NLLLTLTVFGVILGAVCGGLL EAT2_HUMAN 44 44 -
NAFILLTVSAVVIGVSLAFAL EAT4_HUMAN 56 56 -
NLLLTLTVLGVIMGALCGGLL O57322 44 44 -
NGFVLFTVIAVVVGSILGFSV O57321 48 48 -
NAFILLTVSAVIIGVSLAFAL EAT4_MOUSE 53 53 -
NWLLLSTVVAVVLGIVIGVLV EAT3_RABIT 18 18 -
HWLLLSTVAAVVLGIVVGVLV EAT3_RAT 18 18 -
HWLLLSTVAAVVLGIVLGVVV EAT3_MOUSE 18 18 -
NAFILLTVSAVIIGVSLAFAL EAT4_RAT 53 53 -
NWVLLSTVAAVVLGITTGVLV EAT3_HUMAN 18 18 -
NLLLILTIGGVILGSVFGTLL O57323 38 38 -
NWLLLSTVVAVVLGIVIGVLV EAT3_BOVIN 18 18 -
NLLLVLTVSSVVLGALCGFLL EAT_ONCVO 8 8 -
NLLLVLTVSSVVLGALCGFLL EAT1_CAEEL 19 19 -
NGLLILSVLSVIVGCLLGFFL EAT5_HUMAN 17 17 -
NGLLILSVLSVIIGCLLGFFL O57324 19 19 -
NGLLTLSMLSVITGCLIGFLL O57325 31 31 -
NLLVLLTVAAVVAGVGLGLGV AAAX_MOUSE 51 51 -
NLLVLLTVVAVVAGVALGLAV AAAT_RABIT 53 53 -
NMLLLMTMAGIVMGVIIGGVL O18210 19 19 -
NLLVLLTVVAVVAGVALGLGV AAAT_HUMAN 52 52 -
QALVLLTVSGVLAGAGLGAAL SATT_HUMAN 42 42 -
HALVLLTVSGVLVGAGMGAAL SATT_MOUSE 42 42 -
NLLLLFTVLGVVVGIGLGFSL EAT4_CAEEL 32 32 -
DLLLVLTIESVVLGVVLGFVI EAT2_CAEEL 6 6 -
NTLLVMTMFSVFLGVVLGFGL EAT3_CAEEL 16 16 -
NLLTIFTIIGVIAGSLLGCGL O16016 17 17 -
NVLTMATVIGVFVGGLIGFII O77062 18 18 -
FSLAWQILFAMVLGILLGSYL GLTP_ECOLI 6 6 -

Motif 2 width=21
Element Seqn Id St Int Rpt
MLQMLVLPLIISSLVTGMAAL EAT1_RAT 91 22 -
MLQMLVLPLIISSLVTGMAAL EAT1_MOUSE 91 22 -
MLQMLVLPLIISSLVTGMAAL EAT1_BOVIN 91 22 -
MLQMLVLPLIISSLVTGMAAL EAT1_HUMAN 91 22 -
MLKMLILPLIISSLITGLSGL EAT2_MOUSE 88 23 -
MLKMLILPLIISSLITGLSGL EAT2_RAT 88 23 -
MLKMLILPLIISSLITGLSGL O54686 85 23 -
MLKMLILPLIISSLITGLSGL O54687 85 23 -
MLKMLILPLIISSLITGLSGL EAT2_HUMAN 88 23 -
MLQMLVLPLIVSSLVTGMASL EAT4_HUMAN 99 22 -
MLKMLILPLVISSLITGLSGL O57322 88 23 -
MLQMLVLPLIVSSLVTGMAAL O57321 91 22 -
MLQMLVLPLIVSSLVTGMASL EAT4_MOUSE 96 22 -
MLKLVILPLIVSSMITGVAAL EAT3_RABIT 62 23 -
MLKLVILPLIISSMITGVAAL EAT3_RAT 62 23 -
MLKLVILPLIVSSMITGVAAL EAT3_MOUSE 62 23 -
MLQMLVLPLIVSSRVTGMASL EAT4_RAT 96 22 -
MLKLIILPLIISSMITGVAAL EAT3_HUMAN 62 23 -
MLKMLILPLVISSLISGLAGL O57323 82 23 -
MLKLVILPLIVSSMITGVATL EAT3_BOVIN 62 23 -
MLKMMILPLIMSSLISGLAQL EAT_ONCVO 51 22 -
MLKMMILPLIMSSLISGLAQL EAT1_CAEEL 62 22 -
MLKMMILPLVFSSLMSGLASL EAT5_HUMAN 60 22 -
MLKMLILPLVVSSLMSGLAAL O57324 62 22 -
MLKMLILPLITSSLMSGLATM O57325 74 22 -
LLKMIILPLVVCSLIGGAASL AAAX_MOUSE 98 26 -
LLKMIILPLVVCSLVGGAASL AAAT_RABIT 100 26 -
MLKAMVLPLIAASIVSGLSQL O18210 62 22 -
LLRMIILPLVVCSLIGGAASL AAAT_HUMAN 99 26 -
MLRMIILPLVVCSLVSGAASL SATT_HUMAN 85 22 -
MLRMIILPLVVCSLVSGAASL SATT_MOUSE 85 22 -
MLKMLILPMIMSSIITSLASL EAT4_CAEEL 77 24 -
IVEMMILPLIMSSVISALAQV EAT2_CAEEL 49 22 -
VLKMMILPLIFSSLISGELKL EAT3_CAEEL 59 22 -
MLKSLIVPLLVSSIVSAIGSL O16016 62 24 -
MLKCLIVPLLVSSITSAIGGL O77062 63 24 -
LIKMIVVPIVISTLVVGIAGV GLTP_ECOLI 51 24 -

Motif 3 width=26
Element Seqn Id St Int Rpt
GMRAVVYYMTTTIIAVVIGIIIVIII EAT1_RAT 120 8 -
GMRAVVYYMTTTIIAVVIGIIIVIII EAT1_MOUSE 120 8 -
GMRAVVYYMTTTIIAVVIGIIIVIII EAT1_BOVIN 120 8 -
GMRAVVYYMTTTIIAVVIGIIIVIII EAT1_HUMAN 120 8 -
GTRAMVYYMSTTIIAAVLGVILVLAI EAT2_MOUSE 117 8 -
GTRAMVYYMSTTIIAAVLGVILVLAI EAT2_RAT 117 8 -
GTRAMVYYMSTTIIAAVLGVILVLAI O54686 114 8 -
GTRAMVYYMSTTIIAAVLGVILVLAI O54687 114 8 -
GTRAMVYYMSTTIIAAVLGVILVLAI EAT2_HUMAN 117 8 -
GMRAAVYYMVTTIIAVFIGILMVTII EAT4_HUMAN 128 8 -
GTRAMVYYMVTTVIAAILGVILVLAI O57322 117 8 -
GLRAVVYYMTTTVIAVFIGIVIVIIV O57321 120 8 -
GMRAAVYYMVTTVIAVFIGILMVTII EAT4_MOUSE 125 8 -
GLRAVLYYFCTTIIAVILGIVLVVSI EAT3_RABIT 91 8 -
GLRAVVYYFSTTVIAVILGIVLVVSI EAT3_RAT 91 8 -
GLRAVVYYFSTTVIAVILGIVLVVSI EAT3_MOUSE 91 8 -
GMRAAVYYMVTTVIAVFIGILMVTII EAT4_RAT 125 8 -
GLRAVVYYFCTTLIAVILGIVLVVSI EAT3_HUMAN 91 8 -
GTRAMVYYMSTTILAAVLGVILVLSI O57323 111 8 -
GLRAVVYYFCTTLIAVILGIVLVVSI EAT3_BOVIN 91 8 -
GSLAVTYYMFTTAVAVVTGIFLVLVI EAT_ONCVO 80 8 -
GSLAVTYYMFTTAVAVVTGIFLVLVI EAT1_CAEEL 91 8 -
GVLTVAYYLWTTFMAVIVGIFMVSII EAT5_HUMAN 89 8 -
GIITIAYYLWTTFVAVIVGIVMVSII O57324 91 8 -
GLITITYYLWTTFLAVAVGIILVICI O57325 103 8 -
GAWALLFFLVTTLLASALGVGLALAL AAAX_MOUSE 127 8 -
GAWALLFFLVTTLLASALGVGLALAL AAAT_RABIT 129 8 -
GSRAVMYYAITTTHAVILGIIVVSII O18210 91 8 -
GAWALLFFLVTTLLASALGVGLALAL AAAT_HUMAN 128 8 -
GGIAVAYFGLTTLSASALAVALAFII SATT_HUMAN 114 8 -
GGIAVAYFGLTTLSASALAVALAFII SATT_MOUSE 114 8 -
GMVSMIYYTLTTFFAVFLGIVLVSVI EAT4_CAEEL 106 8 -
GIVTIIYYMITTFLATFTGIILVSSI EAT2_CAEEL 78 8 -
GASTVLYYLSTAVLATILGIFLVTVI EAT3_CAEEL 105 25 -
GLRAIIYYMTTTICAVMLGIALVTTI O16016 91 8 -
ATRAITYYFVTTISAVILGICLVTTL O77062 92 8 -
GAKTIIYFEVITTVAIILGITLANVF GLTP_ECOLI 81 9 -

Motif 4 width=23
Element Seqn Id St Int Rpt
VNGVNALGLVVFSMCFGFVIGNM EAT1_RAT 238 92 -
VNGVNALGLVVFSMCFGFVIGNM EAT1_MOUSE 238 92 -
VNGVNALGLVVFSMCFGFVIGNM EAT1_BOVIN 238 92 -
VNGVNALGLVVFSMCFGFVIGNM EAT1_HUMAN 238 92 -
KDGMNVLGLIGFFIAFGIAMGKM EAT2_MOUSE 236 93 -
KDGMNVLGLIGFFIAFGIAMGKM EAT2_RAT 236 93 -
KDGMNVLGLIGFFIAFGIAMGKM O54686 233 93 -
KDGMNVLGLIGFFIAFGIAMGKM O54687 233 93 -
KDGMNVLGLIGFFIAFGIAMGKM EAT2_HUMAN 237 94 -
ANGINALGLVVFSVAFGLVIGGM EAT4_HUMAN 263 109 -
KDGMNVLGLIGFFIAFGISMGKM O57322 237 94 -
VNGVNALGLVVFSMCFGLVIGNM O57321 239 93 -
ANGINALGLVVFSVAFGLVIGGM EAT4_MOUSE 260 109 -
SDGINVLGLIVFCLVFGLVIGKM EAT3_RABIT 207 90 -
SDGINVLGLIIFCLVFGLVIGKM EAT3_RAT 206 89 -
SDGINVLGLIIFCLVFGLVIGKM EAT3_MOUSE 206 89 -
ANGINALGLVVFSVAFGLVIGGM EAT4_RAT 260 109 -
SDGINVLGLIVFCLVFGLVIGKM EAT3_HUMAN 207 90 -
KAGMNVLGLIGFFIAFGIAMGKM O57323 236 99 -
SDGINVLGLIVFCLVLGIVIGRK EAT3_BOVIN 207 90 -
TSGMNVLGVIVFCIAIGISLSQL EAT_ONCVO 189 83 -
TSGMNVLGVIVFCIAIGISLSQL EAT1_CAEEL 200 83 -
SDGMNVLGIVFFSATMGIMLGRM EAT5_HUMAN 217 102 -
SEGMNVLGIVIFSATMGIMLGRM O57324 219 102 -
NTEMNVLGIVIFSATIGLLLGKM O57325 229 100 -
VEGMNILGLVVFAIVFGVALRKL AAAX_MOUSE 238 85 -
EEGMNILGLVVFAIVFGVALRKL AAAT_RABIT 227 72 -
VDGMNVLGIIVFCIVMGLVVSRI O18210 187 70 -
VEGMNILGLVVFAIVFGVALRKL AAAT_HUMAN 226 72 -
IEGMNILGLVLFALVLGVALKKL SATT_HUMAN 218 78 -
VEGMNILGLVLFALVLGVALKKL SATT_MOUSE 218 78 -
SDGMNILGLVVFSVALGIVIGVI EAT4_CAEEL 219 87 -
TNEMNVLGLIVFCSGFGIILSIL EAT2_CAEEL 183 79 -
TKGMNILGIIVFCTGFGIVISQL EAT3_CAEEL 207 76 -
QSGSNVLGLVCFSIVLGITLGKM O16016 191 74 -
REGSNVLGLVMFSVILGTTIGRM O77062 191 73 -
MAKGEMLPIIFFSVLFGLGLSSL GLTP_ECOLI 155 48 -

Motif 5 width=20
Element Seqn Id St Int Rpt
IMWYAPLGILFLIAGKILEM EAT1_RAT 285 24 -
IMWYAPLGILFLIAGKILEM EAT1_MOUSE 285 24 -
IMWYAPLGILFLIAGKIVEM EAT1_BOVIN 285 24 -
IMWYAPVGILFLIAGKIVEM EAT1_HUMAN 285 24 -
IMWYSPLGIACLICGKIIAI EAT2_MOUSE 283 24 -
IMWYSPLGIACLICGKIIAI EAT2_RAT 283 24 -
IMWYSPLGIACLICGKIIAI O54686 280 24 -
IMWYSPLGIACLICGKIIAI O54687 280 24 -
IMWYSPLGIACLICGKIIAI EAT2_HUMAN 284 24 -
IIWYAPVGILFLIAGKILEM EAT4_HUMAN 310 24 -
IMWYSPLGIACLICGKIIAI O57322 284 24 -
IMWYAPIGILFLIAGKIAEM O57321 286 24 -
IIWYAPVGILFLIAGKILEM EAT4_MOUSE 307 24 -
IMCYMPLGILFLIAGKIIEV EAT3_RABIT 254 24 -
IMCYMPIGILFLIAGKIIEV EAT3_RAT 253 24 -
IMCYMPIGILFLIAGKIIEV EAT3_MOUSE 253 24 -
IIWYAPVGILFLIAGKILEM EAT4_RAT 307 24 -
IMCYMPLGILFLIAGKIIEV EAT3_HUMAN 254 24 -
IMWYSPFGIACLICGKIAAI O57323 283 24 -
IMCYMPIGILFLIAGKIIEV EAT3_BOVIN 254 24 -
VMWYSPFGILCLIMGKILEI EAT_ONCVO 236 24 -
VMWYSPFGIFCLIMGKILEI EAT1_CAEEL 247 24 -
AVWYFPFGIVFLIAGKILEM EAT5_HUMAN 264 24 -
SVWYFPFGIVFLIAGKILEM O57324 266 24 -
AVWYFPFGIVFLIAGKILDM O57325 276 24 -
IMWYAPVGILFLVASKIVEM AAAX_MOUSE 285 24 -
IMWYAPVGILFLVASKIVEM AAAT_RABIT 274 24 -
IMWLGPIGIPSLIAQKMLEV O18210 234 24 -
IMWYAPVGIMFLVAGKIVEM AAAT_HUMAN 273 24 -
IMWYVPVGIMFLVGSKIVEM SATT_HUMAN 265 24 -
IMWYVPIGIMFLIGSKIVEM SATT_MOUSE 265 24 -
VIIYSPVGITFLIAAQIVGM EAT4_CAEEL 266 24 -
LMWCYPIGILSLVCKNIIDI EAT2_CAEEL 230 24 -
LMWFAPLGITCLICGNLLEL EAT3_CAEEL 254 24 -
VIWLSPLGVFFLVTAKIMEI O16016 238 24 -
VIWISPLGVAFLIAAKIIEM O77062 238 24 -
VMRYAPVGVFALIAVTVANF GLTP_ECOLI 203 25 -

Motif 6 width=20
Element Seqn Id St Int Rpt
IVGLLIHAVIVLPLLYFLVT EAT1_RAT 322 17 -
IVGLLIHAVIVLPLLYFLVT EAT1_MOUSE 322 17 -
IVGLLIHAVIVLPLLYFLVT EAT1_BOVIN 322 17 -
IVGLLIHAVIVLPLLYFLVT EAT1_HUMAN 322 17 -
IVGLIIHGGIFLPLIYFVVT EAT2_MOUSE 320 17 -
IVGLIIHGGIFLPLIYFVVT EAT2_RAT 320 17 -
IVGLIIHGGIFLPLIYFVVT O54686 317 17 -
IVGLIIHGGIFLPLIYFVVT O54687 317 17 -
IIGLIIHGGIFLPLIYFVVT EAT2_HUMAN 321 17 -
IVGLFLHAGIVLPLIYFLVT EAT4_HUMAN 347 17 -
IVGLIIHGAIFLPLIYFAIT O57322 321 17 -
IIGLLIHAVIVLPLLYFAVT O57321 323 17 -
IVGLFLHAGGVLPLIYFLVT EAT4_MOUSE 344 17 -
LSGLAIHSIVILPLIYFIVV EAT3_RABIT 290 16 -
LSGLAIHSLVVLPLIYFIVV EAT3_RAT 289 16 -
LSGLAIHSLIVLPLLYFIVV EAT3_MOUSE 289 16 -
IVGLFLHAGGVLPLIYFLVT EAT4_RAT 344 17 -
LTGLAIHSIVILPLIYFIVV EAT3_HUMAN 290 16 -
IVGLVIHGGIVLPLIFFSIT O57323 320 17 -
LSGLAIHSIVILPLIYFIIV EAT3_BOVIN 290 16 -
LSGLAIHSLISLPLIFFVTT EAT_ONCVO 273 17 -
LSGLAIHSLISLPLIFFVTT EAT1_CAEEL 284 17 -
VCGLVLHGLFILPLLYFFIT EAT5_HUMAN 301 17 -
VCGLVVHGLFILPMMYLFIT O57324 303 17 -
MAGLFIHGVILLPLLYLIFT O57325 313 17 -
LLGHAIHGLLVLPLIYFLFT AAAX_MOUSE 322 17 -
LLGHAIHGLLVLPLIYFLFT AAAT_RABIT 311 17 -
ILGLAIQAFITLPLIYFIGT O18210 271 17 -
LLGHAIHGLLVLPLIYFLFT AAAT_HUMAN 310 17 -
ILGHVIHGGIVLPLIYFVFT SATT_HUMAN 302 17 -
MLGHVIHGGIVLPLVYFAFT SATT_MOUSE 302 17 -
ILGLLIHAFVVIPLLCVVLA EAT4_CAEEL 303 17 -
ICGLMIHSLLTLPLLYFLVT EAT2_CAEEL 267 17 -
CAGLILHTIITVPLMYFFIT EAT3_CAEEL 291 17 -
LLGLFLHGFGTLRILFILAT O16016 275 17 -
MIGLFLHGFGTIAVIFFLGT O77062 275 17 -
LWPLAKLVLLVHFAILFFAL GLTP_ECOLI 227 4 -

Motif 7 width=27
Element Seqn Id St Int Rpt
FVLPVGATINMDGTALYEALAAIFIAQ EAT1_RAT 389 47 -
FVLPVGATINMDGTALYEALAAIFIAQ EAT1_MOUSE 389 47 -
FVLPVGATINMDGTALYEALAAIFIAQ EAT1_BOVIN 389 47 -
FVLPVGATINMDGTALYEALAAIFIAQ EAT1_HUMAN 389 47 -
FVLPVGATINMDGTALYEAVAAIFIAQ EAT2_MOUSE 387 47 -
FVLPVGATINMDGTALYEAVAAIFIAQ EAT2_RAT 387 47 -
FVLPVGATINMDGTALYEAVAAIFIAQ O54686 384 47 -
FVLPVGATINMDGTALYEAVAAIFIAQ O54687 384 47 -
FVLPVGATINMDGTALYEAVAAIFIAQ EAT2_HUMAN 388 47 -
FVLPVGATVNMDGTALYEALAAIFIAQ EAT4_HUMAN 414 47 -
FVLPVGATINMDGTALYEAVAAIFIAQ O57322 388 47 -
FVLPVGATINMDGTALYEALAAIFIAQ O57321 390 47 -
FVLPVGATVNMDGTALYEALAAIFIAQ EAT4_MOUSE 411 47 -
FVLPVGATINMDGTALYEAVAAVFIAQ EAT3_RABIT 357 47 -
FVLPVGATINMDGTALYEAVAAVFIAQ EAT3_RAT 356 47 -
FVLPVGATINMDGTALYEAVAAVFIAQ EAT3_MOUSE 356 47 -
FVLPVGATVNMDGTALYEALAAIFIAQ EAT4_RAT 411 47 -
FVLPVGATINMDGTALYEAVAAVFIAQ EAT3_HUMAN 357 47 -
FVLPIGATINMDGTALYEAVAAIFIAQ O57323 387 47 -
FVLPVGATINMDGTALYEAVAAVFIAQ EAT3_BOVIN 357 47 -
FVLPVGATINMDGTALYEAVAAIFIAQ EAT_ONCVO 340 47 -
FVLPVGATINMDGTALYEAVAAIFIAQ EAT1_CAEEL 351 47 -
FVLPVGATINMDGTALYEAVAAIFIAQ EAT5_HUMAN 368 47 -
FVLPVGATINMDGTALYEAVAAIFIAQ O57324 370 47 -
FVLPVGATINMDGTALYEAVAAIFIAQ O57325 380 47 -
FILPIGATVNMDGAALFQCVAAVFIAQ AAAX_MOUSE 389 47 -
FVLPIGATVNMDGAALFQCVAAVFIAQ AAAT_RABIT 378 47 -
FVLPVGAMVNMDGTALYEATASIFIAQ O18210 337 46 -
FILPIGATVNMDGAALFQCVAAVFIAQ AAAT_HUMAN 377 47 -
FILPIGATVNMDGAAIFQCVAAVFIAQ SATT_HUMAN 369 47 -
FILPIGATVNMDGAAIFQCVAAVFIAQ SATT_MOUSE 369 47 -
FVLPLGATINMDGTALYEAVAAIYISQ EAT4_CAEEL 370 47 -
FVLPLGATITMDGTALYEAVAVIFIAQ EAT2_CAEEL 334 47 -
FVLPLGSTINMDGNALYEAVAVIFIAQ EAT3_CAEEL 374 63 -
FVIPIGATINMDGTALYEAVAAIFIAQ O16016 341 46 -
FVIPVGATINMDGTALYEAVAALFIAQ O77062 341 46 -
FVVPTGYSFNLDGSTLYQSIAAIFIAQ GLTP_ECOLI 303 56 -

Motif 8 width=20
Element Seqn Id St Int Rpt
GQIITISITATAASIGAAGI EAT1_RAT 424 8 -
GQIITISITATAASIGAAGI EAT1_MOUSE 424 8 -
GQIITISITATAASIGAAGI EAT1_BOVIN 424 8 -
GQIITISITATAASIGAAGI EAT1_HUMAN 424 8 -
GQIVTVSLTATLASIGAASI EAT2_MOUSE 422 8 -
GQIVTVSLTATLASIGAASI EAT2_RAT 422 8 -
GQIVTVSLTATLASIGAASI O54686 419 8 -
GQIVTVSLTATLASIGAASI O54687 419 8 -
GQIVTVSLTATLASVGAASI EAT2_HUMAN 423 8 -
GQITTISITATAASVGAAGI EAT4_HUMAN 449 8 -
GQIITVSLTATLASVGAASI O57322 423 8 -
GQILTISITATAASIGAAGI O57321 425 8 -
GQITTISITATAASVGAAGI EAT4_MOUSE 446 8 -
GQIITISVTATAASIGAAGV EAT3_RABIT 392 8 -
GQIITISITATAASIGAAGV EAT3_RAT 391 8 -
GQIVTISITATAASIGAAGV EAT3_MOUSE 391 8 -
GQITTISITATAASVGAAGI EAT4_RAT 446 8 -
GQIITISITATSASIGAAGV EAT3_HUMAN 392 8 -
GQIATVSLTATLASVGAASI O57323 422 8 -
GQIITISVTATAASIGAAGV EAT3_BOVIN 392 8 -
GQVVTVSLTATLASIGAASV EAT_ONCVO 375 8 -
GQVVTVSLTATLASIGAASV EAT1_CAEEL 386 8 -
GQIITISITGTAASIGAAGI EAT5_HUMAN 403 8 -
GQIITISITATAASIGAAGI O57324 405 8 -
GQIITISITATAASIGAAGI O57325 415 8 -
VKIITILVTATASSVGAAGI AAAX_MOUSE 424 8 -
VKIITILVTATASSVGAAGI AAAT_RABIT 413 8 -
GQIVTVSITATLASIGAASI O18210 372 8 -
VKIITILVTATASSVGAAGI AAAT_HUMAN 412 8 -
GQIFTILVTATASSVGAAGV SATT_HUMAN 404 8 -
GQIFTILVTATASSVGAAGV SATT_MOUSE 404 8 -
GEVVLVSLTATLASIGAAGI EAT4_CAEEL 405 8 -
MDLVTISITTTVASIGSGSV EAT2_CAEEL 369 8 -
AEVLTVSITATIASIGLGSV EAT3_CAEEL 409 8 -
GKIIAVSVTATAASIGAAGI O16016 376 8 -
GTIVAVSITATAASIGAAGI O77062 376 8 -
WQEIILVLTLMVTSKGIAGV GLTP_ECOLI 338 8 -

Motif 9 width=21
Element Seqn Id St Int Rpt
MVIVLTSVGLPTDDITLIIAV EAT1_RAT 451 7 -
MVIVLTSVGLPTDDITLIIAV EAT1_MOUSE 451 7 -
MVIVLTSVGLPTDDITLIIAV EAT1_BOVIN 451 7 -
MVIVLTSVGLPTDDITLIIAV EAT1_HUMAN 451 7 -
MLLILTAVGLPTEDISLLVAV EAT2_MOUSE 449 7 -
MLLILTAVGLPTEDISLLVAV EAT2_RAT 449 7 -
MLLILTAVGLPTEDISLLVAV O54686 446 7 -
MLLILTAVGLPTEDISLLVAV O54687 446 7 -
MLLILTAVGLPTEDISLLVAV EAT2_HUMAN 450 7 -
MVIVLTSVGLPTEDITLIIAV EAT4_HUMAN 476 7 -
MLLILTAVGLPTQDISLLVAV O57322 450 7 -
MVIVLTSVGLPTDDITLIIAV O57321 452 7 -
MVIVLTSVGLPTEDITLIIAV EAT4_MOUSE 473 7 -
MVIVLSAVGLPAEDVTLIIAV EAT3_RABIT 419 7 -
MVIVLSAVGLPAEDVTLIIAV EAT3_RAT 418 7 -
MVIVLSAVGLPAEDVTLIIAV EAT3_MOUSE 418 7 -
MVIVLTSVGLPTEDITLIIAV EAT4_RAT 473 7 -
MVIVLSAVGLPAEDVTLIIAV EAT3_HUMAN 419 7 -
MLLILTAVGLPTQDISLLIAV O57323 449 7 -
MVIVLSAVGLPAEDVTLIIAV EAT3_BOVIN 419 7 -
MLLVLTAVGLPVKDVSLIVAV EAT_ONCVO 402 7 -
MLLVLTAVGLPVKDVSLIVAV EAT1_CAEEL 413 7 -
MVIVLTSVGLPTDDITLIIGV EAT5_HUMAN 430 7 -
MVIVLTSVGLPTDDITLIIAV O57324 432 7 -
MVIVLTSVGLPTDDITLIVAV O57325 442 7 -
LAIILEAVSLPVKDISLILAV AAAX_MOUSE 451 7 -
LAIILEAVSLPVSEISLILAV AAAT_RABIT 440 7 -
MLIVLTALGLPANDISLILAV O18210 399 7 -
LAIILEAVNLPVDHISLILAV AAAT_HUMAN 439 7 -
IAIILEAIGLPTHDLPLILAV SATT_HUMAN 431 7 -
IAIILEAIGLPTHDLSLILAV SATT_MOUSE 431 7 -
MIMVLIAIGLPTNLFILIFPV EAT4_CAEEL 432 7 -
IVIVLTTVGLPAKDLSLLLTV EAT2_CAEEL 395 6 -
ILLILNTVGLPVRDVSMLFTV EAT3_CAEEL 435 6 -
MVMVLDTVNLPAEDVSLILAV O16016 403 7 -
MVMVLDTVGLEPKDVSLIIAV O77062 403 7 -
LLATLGSVGIPLEGLAFIAGV GLTP_ECOLI 365 7 -