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PR00101

Identifier
ATCASE  [View Relations]  [View Alignment]  
Accession
PR00101
No. of Motifs
6
Creation Date
11-MAR-1992  (UPDATE 22-JUN-1999)
Title
Aspartate carbamoyltransferase signature
Database References
PRINTS; PR00100 AOTCASE
INTERPRO; IPR002082
PDB; 1ACM
SCOP; 1ACM
CATH; 1ACM
Literature References
1. FAURE, M., CAMONIA, J.H. AND JACQUET, M.
Molecular characterisation of a Dictyostelium discoideum gene encoding a
multifunctional enyme of the pyrimidine pathway.
EUR.J.BIOCHEMISTRY 179 345-348 (1989).
 
2. LERNER, C.G. AND SWITZER, R.L.
Cloning and structure of the Bacillus subtilis aspartate transcarbamylase
gene (pyrB).
J.BIOL.CHEM. 261 11156-11165 (1986).
 
3. BECK, D., KEDZIE, K.M. AND WILD, J.R.
Comparison of the aspartate transcarbamylase from Serratia marcescens and
Escherichia coli.
J.BIOL.CHEM. 264 16629-16637 (1989).

Documentation
Aspartate carbamoyltransferase (ATCase) catalyses the formation of 
carbamoyl-aspartate in the pyrimidine biosynthesis pathway, by the 
association of aspartate and carbamoyl-phosphate. This is the commitment 
step in the E.coli pathway and is regulated by feedback inhibition by CTP, 
the final product of the pathway.
 
The structural organisation of the ATCase protein varies considerably 
between different organisms. In bacteria such as E.coli, S.typhimurium and
Serratia marcescens, the ATCase is a dodecamer of 2 catalytic (c) trimers
and 3 regulatory (r) dimers. The catalytic domains are coded for by the
pyrB gene, and the regulatory domains by pyrI. In Gram-positive bacteria
such as B.subillis, ATCase exists as a trimer of catalytic subunits, but
unlike in E.coli, it neither contains nor binds to regulatory subunits. In
eukaryotes, ATCase is found as a single domain in a multifinctional enzyme
that contains activity for glutamine amidotransferase, carbamoylphosphate
synthetase, dihydroorotase, and aspartate carbamoyltransferase.
 
ATCASE is a 6-element fingerprint that provides a signature for aspartate
carbamoyltransferases. The fingerprint was derived from an initial
alignment of 9 sequences: motif 1 encodes a region containing 3 residues
believed to be implicated in binding the phosphoryl group of carbamoyl
phosphate (cf. PROSITE pattern CARBAMOYLTRANSFERASE (PS00097)). Two
iterations on OWL15.0 were required to reach convergence, at which point a
true set comprising 31 sequences was identified. Fourteen partial matches
were also found, all of which are ornithine carbamoyltransferases.
 
An update on SPTR37_9f identified a true set of 39 sequences, and 6
partial matches.
Summary Information
  39 codes involving  6 elements
0 codes involving 5 elements
0 codes involving 4 elements
1 codes involving 3 elements
5 codes involving 2 elements
Composite Feature Index
6393939393939
5000000
4000000
3101001
2505000
123456
True Positives
O15636        O15804        O25716        O27464        
O52067 O58451 O66726 P96079
P96111 PYB1_PEA PYB2_PEA PYB3_PEA
PYR1_DICDI PYR1_DROME PYR1_HUMAN PYR1_MESAU
PYR1_SCHPO PYR1_SQUAC PYR1_YEAST PYRB_ARATH
PYRB_ARCFU PYRB_BACCL PYRB_BACSU PYRB_ECOLI
PYRB_LACLE PYRB_LACPL PYRB_METJA PYRB_MYCTU
PYRB_PSEAE PYRB_PSEPU PYRB_PYRAB PYRB_SALTY
PYRB_SERMA PYRB_SULSO PYRB_SYNY3 PYRB_TREDE
PYRB_VIBS2 Q18990 Q84489
True Positive Partials
Codes involving 3 elements
OTCA_BACSU
Codes involving 2 elements
OTC1_ECOLI OTC2_ECOLI OTC_METJA OTC_METTH
OTC_PYRFU
Sequence Titles
O15636      ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (CARBAMYLASPARTOTRANSKINASE) (ATCASE) - TRYPANOSOMA CRUZI. 
O15804 ASPARTATE TRANSCARBAMOYLASE (EC 2.1.3.2) - PLASMODIUM FALCIPARUM.
O25716 ASPARTATE TRANSCARBAMOYLASE (PYRB) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O27464 ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - METHANOBACTERIUM THERMOAUTOTROPHICUM.
O52067 ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (CARBAMYLASPARTOTRANSKINASE) (ATCASE) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O58451 308AA LONG HYPOTHETICAL ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN - PYROCOCCUS HORIKOSHII.
O66726 ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN - AQUIFEX AEOLICUS.
P96079 ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (CARBAMYLASPARTOTRANSKINASE) (ATCASE) - THERMUS AQUATICUS.
P96111 ASPARTATE CARBAMOYLTRANSFERASE WITH FUSED CATALYTIC AND REGULATORY CHAINS (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (CARBAMYLASPARTOTRANSKINASE) (ATCASE) - THERMOTOGA MARITIMA.
PYB1_PEA ASPARTATE CARBAMOYLTRANSFERASE 1 PRECURSOR (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE 1) (ATCASE 1) - PISUM SATIVUM (GARDEN PEA).
PYB2_PEA ASPARTATE CARBAMOYLTRANSFERASE 2 PRECURSOR (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE 2) (ATCASE 2) - PISUM SATIVUM (GARDEN PEA).
PYB3_PEA ASPARTATE CARBAMOYLTRANSFERASE 3 PRECURSOR (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE 3) (ATCASE 3) - PISUM SATIVUM (GARDEN PEA).
PYR1_DICDI PROTEIN PYR1-3 [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE SYNTHASE (EC 6.3.5.5); ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2); DIHYDROOROTASE (EC 3.5.2.3)] - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).
PYR1_DROME CAD PROTEIN (RUDIMENTARY PROTEIN) [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE SYNTHASE (EC 6.3.5.5); ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2); DIHYDROOROTASE (EC 3.5.2.3)] - DROSOPHILA MELANOGASTER (FRUIT FLY).
PYR1_HUMAN CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE SYNTHASE (EC 6.3.5.5); ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2); DIHYDROOROTASE (EC 3.5.2.3)] - HOMO SAPIENS (HUMAN).
PYR1_MESAU CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE SYNTHASE (EC 6.3.5.5); ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2); DIHYDROOROTASE (EC 3.5.2.3)] - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
PYR1_SCHPO URA1 PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE SYNTHASE (EC 6.3.5.5); ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2)] - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
PYR1_SQUAC CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE SYNTHASE (EC 6.3.5.5); ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2); DIHYDROOROTASE (EC 3.5.2.3)] - SQUALUS ACANTHIAS (SPINY DOGFISH).
PYR1_YEAST URA2 PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE SYNTHASE (EC 6.3.5.5); ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2)] - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
PYRB_ARATH ASPARTATE CARBAMOYLTRANSFERASE PRECURSOR (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
PYRB_ARCFU ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - ARCHAEOGLOBUS FULGIDUS.
PYRB_BACCL ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - BACILLUS CALDOLYTICUS.
PYRB_BACSU ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - BACILLUS SUBTILIS.
PYRB_ECOLI ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - ESCHERICHIA COLI.
PYRB_LACLE ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - LACTOBACILLUS LEICHMANNII.
PYRB_LACPL ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - LACTOBACILLUS PLANTARUM.
PYRB_METJA ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - METHANOCOCCUS JANNASCHII.
PYRB_MYCTU ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - MYCOBACTERIUM TUBERCULOSIS.
PYRB_PSEAE ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - PSEUDOMONAS AERUGINOSA.
PYRB_PSEPU ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - PSEUDOMONAS PUTIDA.
PYRB_PYRAB ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - PYROCOCCUS ABYSSI.
PYRB_SALTY ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - SALMONELLA TYPHIMURIUM.
PYRB_SERMA ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - SERRATIA MARCESCENS.
PYRB_SULSO ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - SULFOLOBUS SOLFATARICUS.
PYRB_SYNY3 ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
PYRB_TREDE ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - TREPONEMA DENTICOLA.
PYRB_VIBS2 ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - VIBRIO SP. (STRAIN 2693).
Q18990 D2085.1 PROTEIN - CAENORHABDITIS ELEGANS.
Q84489 SIMILAR TO D. DISCOIDEUM ASPARTATE TRANSCARBAMYLASE - PARAMECIUM BURSARIA CHLORELLA VIRUS 1 (PBCV-1).

OTCA_BACSU ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (EC 2.1.3.3) (OTCASE) - BACILLUS SUBTILIS.

OTC1_ECOLI ORNITHINE CARBAMOYLTRANSFERASE CHAIN I (EC 2.1.3.3) (OTCASE-1) - ESCHERICHIA COLI.
OTC2_ECOLI ORNITHINE CARBAMOYLTRANSFERASE CHAIN F (EC 2.1.3.3) (OTCASE-2) - ESCHERICHIA COLI.
OTC_METJA ORNITHINE CARBAMOYLTRANSFERASE (EC 2.1.3.3) (OTCASE) - METHANOCOCCUS JANNASCHII.
OTC_METTH ORNITHINE CARBAMOYLTRANSFERASE (EC 2.1.3.3) (OTCASE) - METHANOBACTERIUM THERMOAUTOTROPHICUM.
OTC_PYRFU ORNITHINE CARBAMOYLTRANSFERASE (EC 2.1.3.3) (OTCASE) - PYROCOCCUS FURIOSUS.
Scan History
OWL15_0    2  100  NSINGLE    
OWL18_0 1 100 NSINGLE
OWL19_1 1 100 NSINGLE
OWL26_0 1 310 NSINGLE
SPTR37_9f 3 55 NSINGLE
Initial Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
LMKGHVITTIFFEPSTRTCSSFI PYR1_YEAST 1944 1944 -
LLKHKVIASCFFEASTRTRLSFE PYRB_SERMA 38 38 -
LLPGKIMASVFYEVSTRTPCSFA PYR1_DROME 1958 1958 -
LLKHKVIASCFFEASTRTRLSFE PYRB_SALTY 38 38 -
QLTGKFAANLFFEPSTRTRFSFE PYRB_BACSU 33 33 -
LLKHKVIASCFFEASTRTRLSFE DTECC 39 39 -
LLKGKVLATLFYEPSTRTQCSFT PYR1_DICDI 1214 1214 -
ILKGKVMASMFYEVSTRTSSSFA PYR1_HUMAN 208 208 -
ILKGKVMASMFYEVSTRTSSSFA PYR1_MESAU 1959 1959 -

Motif 2 width=10
Element Seqn Id St Int Rpt
LVSSVKKGET PYR1_YEAST 1982 15 -
ITSSVKKGET PYR1_DROME 1996 15 -
NTSLGKKGET DTECC 79 17 -
TSTSVQKGET PYRB_BACSU 71 15 -
NTSLGKKGET PYRB_SALTY 78 17 -
VSSSVAKGES PYR1_DICDI 1252 15 -
ATSSVQKGES PYR1_HUMAN 246 15 -
ATSSVQKGES PYR1_MESAU 1997 15 -
NTSLGKKGET PYRB_SERMA 78 17 -

Motif 3 width=18
Element Seqn Id St Int Rpt
EHSHQALLDIFTDPRVGG PYR1_DROME 2048 42 -
QHPTQTLLDLFTIQETEG DTECC 134 45 -
EHPTQALLDVFTIREELG PYR1_DICDI 1306 44 -
EHPTQALLDIFTIREELG PYR1_HUMAN 300 44 -
EHPTQALLDIFTIREELG PYR1_MESAU 2051 44 -
EHPTQAFLDLFTIREEIG PYR1_YEAST 2036 44 -
QHPTQTLLDLFTIQETQG PYRB_SERMA 131 43 -
QHPTQTLLDLFTIQETQG PYRB_SALTY 133 45 -
QHPTQSLLDLMTIYEEFN PYRB_BACSU 126 45 -

Motif 4 width=10
Element Seqn Id St Int Rpt
LYMTRVQKER PYRB_SALTY 226 75 -
LYMTRVQKER DTECC 226 74 -
VMLLRIQNER PYRB_BACSU 207 63 -
LYVTRVQKER PYR1_DICDI 1397 73 -
LYMTRIQKER PYR1_HUMAN 391 73 -
LYMTRIQKER PYR1_MESAU 2142 73 -
LYCTRVQEER PYR1_YEAST 2128 74 -
LYMTRVQKER PYRB_SERMA 223 74 -
ALHDSHSRER PYR1_DROME 2139 73 -

Motif 5 width=6
Element Seqn Id St Int Rpt
VMHPMP PYR1_MESAU 2181 29 -
VMHPLP PYR1_DICDI 1436 29 -
VMHPMP PYR1_HUMAN 430 29 -
IMHPLP PYR1_YEAST 2167 29 -
VLHPLP PYRB_SERMA 259 26 -
VLHPLP PYR1_DROME 2178 29 -
VLHPLP PYRB_SALTY 263 27 -
IMHPAP PYRB_BACSU 246 29 -
VLHPLP DTECC 264 28 -

Motif 6 width=15
Element Seqn Id St Int Rpt
YFQQAGNGIFARSAL PYRB_SERMA 281 16 -
IFKQMKNGVFIRMAV PYRB_BACSU 270 18 -
YFRQMENGLYVRMSL PYR1_DICDI 1458 16 -
YFQQAGNGIFARQAL DTECC 286 16 -
YFQQAGNGIFAAQAL PYRB_SALTY 285 16 -
YFRQAEYGMYIRMAL PYR1_DROME 2200 16 -
YFRQAENGMYIRMAL PYR1_HUMAN 452 16 -
YFRQAENGMYIRMAL PYR1_MESAU 2203 16 -
YFRQMKYGLFVRMAL PYR1_YEAST 2189 16 -
Final Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
YAKGKILATLFFEPSTRTRLSFE PYRB_PYRAB 41 41 -
YAKGKILATLFFEPSTRTRLSFE O58451 41 41 -
ILKGKVMASMFYEVSTRTSSSFR PYR1_SQUAC 1976 1976 -
MLKGYLMATLFYEPSTRTRLSFE PYB1_PEA 116 116 -
ILKGYLMATLFYEPSTRTRLSFE PYB2_PEA 115 115 -
ILKGYLMATLFYEPSTRTRLSFE PYB3_PEA 121 121 -
LLKGKVLATLFYEPSTRTQCSFT PYR1_DICDI 1214 1214 -
ILKGKVMASMFYEVSTRTSSSFA PYR1_HUMAN 208 208 -
ILKGKVMASMFYEVSTRTSSSFA PYR1_MESAU 1959 1959 -
ILKGYLMATLFYEPSTRTRLSFE PYRB_ARATH 120 120 -
LLEGKILATVFYEPSTRTRLSFE PYRB_METJA 37 37 -
ILEGKILGNLFFEPSTRTRMSFE PYRB_ARCFU 38 38 -
ILNGKVLVNLFYEVSTRTSCSFS Q18990 1913 1913 -
LCYGKLLCTMFFEPSTRTSSSFD PYR1_SCHPO 1972 1972 -
ALRGKILGMMFYEPSTRTRLSFE O27464 38 38 -
LMKGHVITTIFFEPSTRTCSSFI PYR1_YEAST 1944 1944 -
LLKHKVIASCFFEASTRTRLSFE PYRB_ECOLI 38 38 -
LLKNKVIASCFFEASTRTRLSFE PYRB_VIBS2 39 39 -
LLKHKVIASCFFEASTRTRLSFE PYRB_SERMA 38 38 -
SLRGKKMLTYFEEPSTRTRLSFE Q84489 54 54 -
LLPGKIMASVFYEVSTRTPCSFA PYR1_DROME 1958 1958 -
LLKHKVIASCFFEASTRTRLSFE PYRB_SALTY 38 38 -
LLQGRIMTPLFFEDSSRTFSSFC O15636 48 48 -
YLENKVFCSVFLEPSTRTRCSFD O15804 57 57 -
QLTGKFAANLFFEPSTRTRFSFE PYRB_BACSU 33 33 -
PAAPMYVANLFFEPSTRTKCSFE PYRB_BACCL 33 33 -
ILSGKTISIAFFEPSTRTYLSFQ PYRB_SULSO 35 35 -
ALQGFTVATVFFEPSTRTRISFE P96079 38 38 -
TLRGRTVVTMFYENSTRTRVSFE PYRB_MYCTU 41 41 -
ALQGQVVTNLFFEPSTRTRSSFE PYRB_SYNY3 46 46 -
LSQPTFAMNLFFENSTRTHTSFE PYRB_LACPL 36 36 -
LLRGKTVCNVFFENSTRTRTTFE PYRB_PSEPU 55 55 -
LLRGKTVCNVFFENSTRTRTTFE PYRB_PSEAE 54 54 -
KMHNKIIVALFFENSTRTVSSFE O25716 43 43 -
KMHNKIIVALFFENSTRTVSSFE O52067 43 43 -
LSRPIFCTNMFFENSTRTHTSFE PYRB_LACLE 71 71 -
ETIKASAVLFFSEPSTRTRLSFE O66726 31 31 -
NDKDFGIYEVFLEPSTRTKESFR PYRB_TREDE 49 49 -
KKRNVGIYIVFVEPSTRTKESFI P96111 47 47 -

Motif 2 width=10
Element Seqn Id St Int Rpt
STSSVKKGES PYRB_PYRAB 80 16 -
STSSVKKGES O58451 80 16 -
ATSSVQKGES PYR1_SQUAC 2014 15 -
EFSSAAKGET PYB1_PEA 156 17 -
EFSSAAKGET PYB2_PEA 155 17 -
EFSSAAKGET PYB3_PEA 161 17 -
VSSSVAKGES PYR1_DICDI 1252 15 -
ATSSVQKGES PYR1_HUMAN 246 15 -
ATSSVQKGES PYR1_MESAU 1997 15 -
EFSSAAKGET PYRB_ARATH 160 17 -
KSSSVAKGES PYRB_METJA 76 16 -
EASSIAKGET PYRB_ARCFU 77 16 -
QSSSVQKGET Q18990 1951 15 -
SASSVNKGES PYR1_SCHPO 2010 15 -
GATSAVKGES O27464 77 16 -
LVSSVKKGET PYR1_YEAST 1982 15 -
NTSLGKKGET PYRB_ECOLI 78 17 -
NTSLAKKGET PYRB_VIBS2 79 17 -
NTSLGKKGET PYRB_SERMA 78 17 -
VNSSKAKGET Q84489 93 16 -
ITSSVKKGET PYR1_DROME 1996 15 -
NTSLGKKGET PYRB_SALTY 78 17 -
EASSINKGET O15636 86 15 -
NSTSFYKGET O15804 96 16 -
TSTSVQKGET PYRB_BACSU 71 15 -
ERSSVQKGET PYRB_BACCL 71 15 -
ESTSVAKGEN PYRB_SULSO 74 16 -
QTSSLQKGES P96079 76 15 -
AGSSVGKGES PYRB_MYCTU 79 15 -
GTSSLTKGET PYRB_SYNY3 84 15 -
KTSSVTKGES PYRB_LACPL 74 15 -
STSSTSKGET PYRB_PSEPU 93 15 -
STSSTSKGET PYRB_PSEAE 92 15 -
QTSSASKGET O25716 81 15 -
QTSSTSKGET O52067 81 15 -
SHSSVNKGEN PYRB_LACLE 109 15 -
SESSTVKGES O66726 69 15 -
ESSSFNKGES PYRB_TREDE 87 15 -
EHSSFNKQES P96111 88 18 -

Motif 3 width=18
Element Seqn Id St Int Rpt
QHPTQTLLDLYTIKKEFG PYRB_PYRAB 134 44 -
QHPTQTLLDLYTIKKEFG O58451 134 44 -
EHPTQALLDIFTIREELG PYR1_SQUAC 2068 44 -
QHPSQALLDVYTIEREIG PYB1_PEA 210 44 -
QHPSQALLDVYTIEREIG PYB2_PEA 209 44 -
QHPSQALLDVYTIEREIG PYB3_PEA 215 44 -
EHPTQALLDVFTIREELG PYR1_DICDI 1306 44 -
EHPTQALLDIFTIREELG PYR1_HUMAN 300 44 -
EHPTQALLDIFTIREELG PYR1_MESAU 2051 44 -
EHPTQALLDVYTIQSEIG PYRB_ARATH 214 44 -
QHPTQTLLDLYTIMREIG PYRB_METJA 130 44 -
QHPTQTLLDLYTIKKECG PYRB_ARCFU 131 44 -
EHPTQALLDVYTIRQEMG Q18990 2005 44 -
EHPTQAFLDLYTIREELG PYR1_SCHPO 2064 44 -
QHPTQTLLDLYTMKRFFG O27464 131 44 -
EHPTQAFLDLFTIREEIG PYR1_YEAST 2036 44 -
QHPTQTLLDLFTIQETQG PYRB_ECOLI 133 45 -
QHPTQTLLDLFSIYETQG PYRB_VIBS2 133 44 -
QHPTQTLLDLFTIQETQG PYRB_SERMA 131 43 -
QHPTQALLDVYTIYDKFG Q84489 147 44 -
EHSHQALLDIFTDPRVGG PYR1_DROME 2048 42 -
QHPTQTLLDLFTIQETQG PYRB_SALTY 133 45 -
EHPTQALLDTLTIHSELG O15636 140 44 -
EHPTQSLLDFYTIHNYFP O15804 150 44 -
QHPTQSLLDLMTIYEEFN PYRB_BACSU 126 45 -
HHPTQSLLDLLTIRQEFG PYRB_BACCL 126 45 -
EHPTQAVIDIYTINKHFN PYRB_SULSO 128 44 -
AHPTQALLDAYTLLEALG P96079 131 45 -
EHPTQALLDALTIRQRLG PYRB_MYCTU 139 50 -
EHPSQGLLDLFTICSQFA PYRB_SYNY3 144 50 -
QHPSQSLLDMLTIYEEFG PYRB_LACPL 130 46 -
AHPTQGMLDMLTIRRHKG PYRB_PSEPU 150 47 -
AHPTQGMLDMLTIRRHKG PYRB_PSEAE 149 47 -
AHPTQALLDLLTLYQHFG O25716 136 45 -
AHPTQALLDLLTLYQHFG O52067 136 45 -
QHPSQSMLDMMTIYNEFG PYRB_LACLE 169 50 -
QHPSQGLIDFFTIKEHFG O66726 125 46 -
EHPTQELLDEFTFIEDNN PYRB_TREDE 153 56 -
EHPTQELLDEYTFLEQNG P96111 154 56 -

Motif 4 width=10
Element Seqn Id St Int Rpt
LYVTRIQKER PYRB_PYRAB 225 73 -
LYVTRIQKER O58451 225 73 -
LYMTRIQKER PYR1_SQUAC 2159 73 -
VYQTRIQKER PYB1_PEA 302 74 -
VYQTRIQKER PYB2_PEA 301 74 -
VYQTRIQKER PYB3_PEA 307 74 -
LYVTRVQKER PYR1_DICDI 1397 73 -
LYMTRIQKER PYR1_HUMAN 391 73 -
LYMTRIQKER PYR1_MESAU 2142 73 -
VYQTRIQRER PYRB_ARATH 306 74 -
LYVTRIQKER PYRB_METJA 222 74 -
LYVTRIQKER PYRB_ARCFU 218 69 -
VYVTRIQKER Q18990 2099 76 -
LYCTRVQKER PYR1_SCHPO 2156 74 -
LYVTRIQKER O27464 222 73 -
LYCTRVQEER PYR1_YEAST 2128 74 -
LYMTRVQKER PYRB_ECOLI 225 74 -
LYMTRVQKER PYRB_VIBS2 225 74 -
LYMTRVQKER PYRB_SERMA 223 74 -
VYMTRIQKER Q84489 238 73 -
ALHDSHSRER PYR1_DROME 2139 73 -
LYMTRVQKER PYRB_SALTY 226 75 -
LYTTRLQKER O15636 238 80 -
IYMTRIQKER O15804 255 87 -
VMLLRIQNER PYRB_BACSU 207 63 -
VMLLRIQHER PYRB_BACCL 207 63 -
LYVTRIQKER PYRB_SULSO 217 71 -
VMVLRLQKER P96079 213 64 -
VLMLRVQAER PYRB_MYCTU 223 66 -
VMTLRLQKER PYRB_SYNY3 242 80 -
MMLLRVQHER PYRB_LACPL 212 64 -
VIMLRLQRER PYRB_PSEPU 235 67 -
VIMLRLQRER PYRB_PSEAE 235 68 -
LMSLRTQTER O25716 219 65 -
LMSLRTQTER O52067 219 65 -
LMLLRVQHER PYRB_LACLE 253 66 -
VIWLRLQKER O66726 209 66 -
WYFTRPQLER PYRB_TREDE 249 78 -
WYFTRLQLER P96111 250 78 -

Motif 5 width=6
Element Seqn Id St Int Rpt
IMHPLP PYRB_PYRAB 264 29 -
IMHPLP O58451 264 29 -
VMHPLP PYR1_SQUAC 2198 29 -
VMHPLP PYB1_PEA 342 30 -
IMHPLP PYB2_PEA 341 30 -
IMHPLP PYB3_PEA 347 30 -
VMHPLP PYR1_DICDI 1436 29 -
VMHPMP PYR1_HUMAN 430 29 -
VMHPMP PYR1_MESAU 2181 29 -
IMHPLP PYRB_ARATH 346 30 -
IMHPLP PYRB_METJA 259 27 -
VMHPLP PYRB_ARCFU 257 29 -
VMHPLP Q18990 2152 43 -
VMHPLP PYR1_SCHPO 2195 29 -
VMHPLP O27464 259 27 -
IMHPLP PYR1_YEAST 2167 29 -
VLHPLP PYRB_ECOLI 263 28 -
VLHPLP PYRB_VIBS2 263 28 -
VLHPLP PYRB_SERMA 259 26 -
IMHPLP Q84489 278 30 -
VLHPLP PYR1_DROME 2178 29 -
VLHPLP PYRB_SALTY 263 27 -
VMHPLP O15636 284 36 -
ILHPLP O15804 294 29 -
IMHPAP PYRB_BACSU 246 29 -
ILHPAP PYRB_BACCL 248 31 -
ILHPLP PYRB_SULSO 256 29 -
LLHPGP P96079 253 30 -
VLHPGP PYRB_MYCTU 264 31 -
VLHPGP PYRB_SYNY3 283 31 -
IMHPAP PYRB_LACPL 255 33 -
VMHPGP PYRB_PSEPU 276 31 -
VMHPGP PYRB_PSEAE 276 31 -
ILHPGP O25716 262 33 -
ILHPGP O52067 262 33 -
IMHPGP PYRB_LACLE 299 36 -
YMHPGP O66726 247 28 -
FYHPLP PYRB_TREDE 290 31 -
FYHPLP P96111 291 31 -

Motif 6 width=15
Element Seqn Id St Int Rpt
YFRQVFNGVPVRMAL PYRB_PYRAB 286 16 -
YFKQVFNGVPVRMAL O58451 286 16 -
YFRQAENGMYVRMAL PYR1_SQUAC 2220 16 -
YFRQAKNGLYIRMAL PYB1_PEA 364 16 -
YFRQAKYGLYIRMAL PYB2_PEA 363 16 -
YFRQAKYGLYIRMAL PYB3_PEA 369 16 -
YFRQMENGLYVRMSL PYR1_DICDI 1458 16 -
YFRQAENGMYIRMAL PYR1_HUMAN 452 16 -
YFRQAENGMYIRMAL PYR1_MESAU 2203 16 -
YFRQAKNGLFIRMAL PYRB_ARATH 368 16 -
YFKQSFYGIPVRMAI PYRB_METJA 281 16 -
YFQQSFYGVPVRMAI PYRB_ARCFU 279 16 -
YFRQAKNGVFVRMSI Q18990 2174 16 -
YFRQMRYGLYIRMAL PYR1_SCHPO 2218 17 -
YFRQAFYGVPVRMAL O27464 281 16 -
YFRQMKYGLFVRMAL PYR1_YEAST 2189 16 -
YFQQAGNGIFARQAL PYRB_ECOLI 285 16 -
YFQQAENGVYAREAL PYRB_VIBS2 285 16 -
YFQQAGNGIFARSAL PYRB_SERMA 281 16 -
YFDQVERGLEMRKAL Q84489 300 16 -
YFRQAEYGMYIRMAL PYR1_DROME 2200 16 -
YFQQAGNGIFAAQAL PYRB_SALTY 285 16 -
YFRQMRYGMFMRMAI O15636 306 16 -
YFTQAENGLYVRMAL O15804 316 16 -
IFKQMKNGVFIRMAV PYRB_BACSU 270 18 -
IFKQMENGVYVRMAV PYRB_BACCL 272 18 -
YFEQASYGVPVRMSI PYRB_SULSO 278 16 -
VNRQVQNGVAVRMAV P96079 277 18 -
VLQQVSNGVQVRMAV PYRB_MYCTU 288 18 -
IQDQVTSGVAIRMAL PYRB_SYNY3 308 19 -
IFQQMTNGVYIRMAM PYRB_LACPL 279 18 -
ILNQVTYGIAVRMAV PYRB_PSEPU 300 18 -
ILNQVTYGIAIRMAV PYRB_PSEAE 300 18 -
VLEQVKNGVAMRMAV O25716 286 18 -
VLEQVKNGVAMRMAV O52067 286 18 -
YAVQMHNGVFVRMAM PYRB_LACLE 323 18 -
IQEQVKNGIPVRKAI O66726 271 18 -
WERQSINGMYVRMVL PYRB_TREDE 315 19 -
WETQARNGYWVRIVL P96111 316 19 -