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PR00094

Identifier
ADENYLTKNASE  [View Relations]  [View Alignment]  
Accession
PR00094
No. of Motifs
5
Creation Date
30-JUL-1991  (UPDATE 09-JUN-1999)
Title
Adenylate kinase signature
Database References

PROSITE; PS00113 ADENYLATE_KINASE
PFAM; PF00406 adenylatekinase
INTERPRO; IPR000850
PDB; 3ADK
SCOP; 3ADK
CATH; 3ADK
Literature References
1. WEILAND, B., TOMASSELLI, A.G., NODA, L.H., FRANK, R. AND SCHULZ, G.E.
The amino acid sequence of GTP:AMP phosphotransferase from beef-heart
mitochondria. Extensive homology with cytosolic adenylate kinase.
EUR.J.BIOCHEMISTRY 143 331-339 (1984).
 
2. TOMASSELLI, A.G. AND NODA, L.H. 
Mitochondrial GTP-AMP phosphotransferase. Kinetic and equilibrium
dialysis studies.
EUR.J.BIOCHEMISTRY 93 263-270 (1979).
 
3. COOPER, A.J. AND FRIEDBERG, E.C.
A putative second adenylate kinase-encoding gene from the yeast
Saccharomyces cerevisiae.
GENE 114 145-148 (1992).

Documentation
Adenylate kinases (ADK) are phosphotransferases that catalyse the 
reversible reaction AMP + MgATP = ADP + MgADP, an essential reaction
for many processes in living cells. Two ADK isozymes have been identified
in mammalian cells - these specifically bind AMP and favour binding to ATP 
over other nucleotide triphosphates (AK1 is cytosolic and AK2 is located
in the mitochondria). A third ADK has been identified in bovine heart and 
human cells [1] - this is a mitochondrial GTP:AMP phosphotransferase, also 
specific for the phosphorylation of AMP, but can only use GTP or ITP as 
substrate [2]. ADK has also been identified in different bacterial species
and in yeast [3]. Two further enzymes are known to be related to the ADK 
family, i.e. yeast uridine monophosphokinase and slime mould UMP-CMP kinase.
 
Within the ADK family there are several conserved regions, including the 
ATP-binding domains. One of the most conserved areas includes an Arg
residue, whose modification inactivates the enzyme, together with an Asp
that resides in the catalytic cleft of the enzyme and participates in a 
salt bridge. 
 
ADENYLTKNASE is a 5-element fingerprint that provides a signature for
adenylate kinases. The fingerprint was derived from an initial alignment
of 6 sequences: motif 3 encodes the region containing the conserved Arg
and Asp residues (cf. PROSITE pattern ADENYLATE_KINASE (PS00113)). Five
iterations on OWL17.1 were required to reach convergence, at which point a
true set comprising 25 sequences was identified, including adenylate
kinases, yeast uridine monophosphokinase, slime mould cytidylate kinase
and blood fluke nucleoside-phosphate kinase. 
 
An update on SPTR37_9f identified a true set of 59 sequences, and 10
partial matches.
Summary Information
  59 codes involving  5 elements
7 codes involving 4 elements
2 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
55959595959
476762
320220
200110
12345
True Positives
KAD1_BOVIN    KAD1_CHICK    KAD1_HUMAN    KAD1_PIG      
KAD1_RABIT KAD1_SCHPO KAD1_YEAST KAD2_BOVIN
KAD2_HUMAN KAD2_RAT KAD2_YEAST KAD3_BOVIN
KAD3_HUMAN KAD3_RAT KADA_ORYSA KADB_ORYSA
KADH_TRIVA KADX_CAEEL KADY_CAEEL KAD_BACST
KAD_BACSU KAD_BORPE KAD_CYPCA KAD_ECOLI
KAD_HAEIN KAD_LACLA KAD_MICLU KAD_MYCCA
KAD_MYCPN KAD_NEIGO KAD_NEIME KAD_NEIMU
KAD_PARDE KAD_PRUAR KAD_SALTY KAD_SCHMA
KAD_STRCO KAD_TREPA KAD_YEREN KCY_DICDI
KCY_PIG O17622 O24706 O29581
O33007 O51378 O53796 O58844
O59845 O66490 O69172 O80954
O82514 O84130 P73302 Q20140
Q20230 UMPK_ARATH UMPK_YEAST
True Positive Partials
Codes involving 4 elements
KADC_MAIZE KAD_HELPY KAD_MYCGE O52352
O59771 P72641 Q27254
Codes involving 3 elements
KAD_GIALA O00846
Codes involving 2 elements
O17803
Sequence Titles
KAD1_BOVIN  ADENYLATE KINASE ISOENZYME 1 (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) (AK1) (MYOKINASE) - BOS TAURUS (BOVINE). 
KAD1_CHICK ADENYLATE KINASE ISOENZYME 1 (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) (AK1) (MYOKINASE) - GALLUS GALLUS (CHICKEN).
KAD1_HUMAN ADENYLATE KINASE ISOENZYME 1 (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) (AK1) (MYOKINASE) - HOMO SAPIENS (HUMAN).
KAD1_PIG ADENYLATE KINASE ISOENZYME 1 (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) (AK1) (MYOKINASE) - SUS SCROFA (PIG).
KAD1_RABIT ADENYLATE KINASE ISOENZYME 1 (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) (AK1) (MYOKINASE) - ORYCTOLAGUS CUNICULUS (RABBIT).
KAD1_SCHPO ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
KAD1_YEAST ADENYLATE KINASE CYTOSOLIC (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
KAD2_BOVIN ADENYLATE KINASE ISOENZYME 2, MITOCHONDRIAL (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - BOS TAURUS (BOVINE).
KAD2_HUMAN ADENYLATE KINASE ISOENZYME 2, MITOCHONDRIAL (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - HOMO SAPIENS (HUMAN).
KAD2_RAT ADENYLATE KINASE ISOENZYME 2, MITOCHONDRIAL (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - RATTUS NORVEGICUS (RAT).
KAD2_YEAST ADENYLATE KINASE 2 (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
KAD3_BOVIN GTP:AMP PHOSPHOTRANSFERASE MITOCHONDRIAL (EC 2.7.4.10) (AK3) - BOS TAURUS (BOVINE).
KAD3_HUMAN GTP:AMP PHOSPHOTRANSFERASE MITOCHONDRIAL (EC 2.7.4.10) (AK3) - HOMO SAPIENS (HUMAN).
KAD3_RAT GTP:AMP PHOSPHOTRANSFERASE MITOCHONDRIAL (EC 2.7.4.10) (AK3) - RATTUS NORVEGICUS (RAT).
KADA_ORYSA ADENYLATE KINASE A (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - ORYZA SATIVA (RICE).
KADB_ORYSA ADENYLATE KINASE B (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - ORYZA SATIVA (RICE).
KADH_TRIVA ADENYLATE KINASE PRECURSOR (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) (AK) - TRICHOMONAS VAGINALIS.
KADX_CAEEL PROBABLE ADENYLATE KINASE ISOENZYME C29E4.8 (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - CAENORHABDITIS ELEGANS.
KADY_CAEEL PROBABLE ADENYLATE KINASE ISOENZYME ZK673.2 (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - CAENORHABDITIS ELEGANS.
KAD_BACST ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - BACILLUS STEAROTHERMOPHILUS.
KAD_BACSU ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) (SUPEROXIDE-INDUCIBLE PROTEIN 16) (SOI16) - BACILLUS SUBTILIS.
KAD_BORPE ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - BORDETELLA PERTUSSIS.
KAD_CYPCA ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - CYPRINUS CARPIO (COMMON CARP).
KAD_ECOLI ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - ESCHERICHIA COLI.
KAD_HAEIN ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - HAEMOPHILUS INFLUENZAE.
KAD_LACLA ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - LACTOCOCCUS LACTIS (SUBSP. LACTIS) (STREPTOCOCCUS LACTIS).
KAD_MICLU ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - MICROCOCCUS LUTEUS (MICROCOCCUS LYSODEIKTICUS).
KAD_MYCCA ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - MYCOPLASMA CAPRICOLUM.
KAD_MYCPN ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - MYCOPLASMA PNEUMONIAE.
KAD_NEIGO ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - NEISSERIA GONORRHOEAE.
KAD_NEIME ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - NEISSERIA MENINGITIDIS.
KAD_NEIMU ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - NEISSERIA MUCOSA.
KAD_PARDE ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - PARACOCCUS DENITRIFICANS.
KAD_PRUAR ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - PRUNUS ARMENIACA (APRICOT).
KAD_SALTY ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - SALMONELLA TYPHIMURIUM.
KAD_SCHMA ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) (AK) - SCHISTOSOMA MANSONI (BLOOD FLUKE).
KAD_STRCO ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - STREPTOMYCES COELICOLOR.
KAD_TREPA ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - TREPONEMA PALLIDUM.
KAD_YEREN ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - YERSINIA ENTEROCOLITICA.
KCY_DICDI CYTIDYLATE KINASE (EC 2.7.4.14) (DEOXYCYTIDYLATE KINASE) (UMP-CMP KINASE) - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).
KCY_PIG UMP-CMP KINASE (EC 2.7.4.14) (CYTIDYLATE KINASE) (DEOXYCYTIDYLATE KINASE) - SUS SCROFA (PIG).
O17622 C29F7.3 PROTEIN - CAENORHABDITIS ELEGANS.
O24706 ADENYLATE KINASE - SYNECHOCOCCUS SP.
O29581 ADENYLATE KINASE (ADK) - ARCHAEOGLOBUS FULGIDUS.
O33007 ADENYLATE KINASE - MYCOBACTERIUM LEPRAE.
O51378 ADENYLATE KINASE (ADK) - BORRELIA BURGDORFERI (LYME DISEASE SPIROCHETE).
O53796 ADENYLATE KINASE - MYCOBACTERIUM TUBERCULOSIS.
O58844 220AA LONG HYPOTHETICAL ADENYLATE KINASE - PYROCOCCUS HORIKOSHII.
O59845 UMP-CMP KINASE - LENTINULA EDODES (SHIITAKE MUSHROOM) (LENTINUS EDODES).
O66490 ADENYLATE KINASE - AQUIFEX AEOLICUS.
O69172 ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - YERSINIA PESTIS.
O80954 PUTATIVE ADENYLATE KINASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O82514 ADENYLATE KINASE (EC 2.7.4.3) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O84130 ADENYLATE KINASE - CHLAMYDIA TRACHOMATIS.
P73302 ADENYLATE KINASE - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
Q20140 F38B2.4 PROTEIN - CAENORHABDITIS ELEGANS.
Q20230 F40F8.1 PROTEIN - CAENORHABDITIS ELEGANS.
UMPK_ARATH URIDYLATE KINASE (EC 2.7.4.-) (UK) (URIDINE MONOPHOSPHATE KINASE) (UMP KINASE) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
UMPK_YEAST URIDYLATE KINASE (EC 2.7.4.-) (UK) (URIDINE MONOPHOSPHATE KINASE) (UMP KINASE) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).

KADC_MAIZE ADENYLATE KINASE, CHLOROPLAST (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - ZEA MAYS (MAIZE).
KAD_HELPY ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
KAD_MYCGE ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - MYCOPLASMA GENITALIUM.
O52352 ADENYLATE KINASE - MYCOPLASMA GALLISEPTICUM.
O59771 URIDYLATE KINASE - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
P72641 ADENYLATE KINASE - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
Q27254 NUCLEOSIDE MONOPHOSPHATE KINASE - BABESIA BOVIS.

KAD_GIALA ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) (AK) - GIARDIA LAMBLIA (GIARDIA INTESTINALIS).
O00846 PUTATIVE URIDYLATE KINASE (EC 2.7.4.-) - PARAMECIUM PRIMAURELIA.

O17803 F13E6.2 PROTEIN - CAENORHABDITIS ELEGANS.
Scan History
OWL17_1    5  100  NSINGLE    
OWL18_0 1 100 NSINGLE
OWL19_1 1 100 NSINGLE
OWL26_0 1 110 NSINGLE
SPTR37_9f 2 150 NSINGLE
Initial Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
VLIGPPGAGKGTQA KAD1_YEAST 9 9 -
ILLGAPGAGKGTQA KAD_ECOLI 3 3 -
VLLGPPGAGKGTQA KAD2_BOVIN 19 19 -
AIMGAPGSGKGTVS N_1AK3B 4 4 -
AIMGAPGSGKGTVS N_1AK3A 4 4 -
AIMGAPGSGKGTVS KAD3_BOVIN 9 9 -

Motif 2 width=15
Element Seqn Id St Int Rpt
GDMLRAAVKSGSELG KAD_ECOLI 31 14 -
GDLLRDNMLRGTEIG N_1AK3A 32 14 -
GDLLRDNMLRGTEIG N_1AK3B 32 14 -
GDMLRAMVASGSELG KAD2_BOVIN 47 14 -
GDMLRSQIAKGTQLG KAD1_YEAST 37 14 -
GDLLRDNMLRGTEIG KAD3_BOVIN 37 14 -

Motif 3 width=17
Element Seqn Id St Int Rpt
FLLDGFPRTVRQAEMLD KAD2_BOVIN 96 34 -
WLLDGFPRTLPQAEALD N_1AK3B 80 33 -
WLLDGFPRTLPQAEALD KAD3_BOVIN 85 33 -
WLLDGFPRTLPQAEALD N_1AK3A 80 33 -
FILDGFPRTIPQAEKLD KAD1_YEAST 87 35 -
FLLDGFPRTIPQADAMK KAD_ECOLI 80 34 -

Motif 4 width=16
Element Seqn Id St Int Rpt
REDDRPETVVKRLKAY N_1AK3B 154 57 -
RSDDNKKALKIRLEAY KAD2_BOVIN 175 62 -
RKDDQEETVRKRLVEY KAD_ECOLI 155 58 -
RSDDNADALKKRLAAY KAD1_YEAST 166 62 -
REDDRPETVVKRLKAY KAD3_BOVIN 159 57 -
REDDRPETVVKRLKAY N_1AK3A 154 57 -

Motif 5 width=15
Element Seqn Id St Int Rpt
AQTEPVLEYYRKKGV N_1AK3B 171 1 -
AQTEPVLEYYRKKGV KAD3_BOVIN 176 1 -
AQTEPIVDFYKKTGI KAD1_YEAST 183 1 -
QMTAPLIGYYSKEAE KAD_ECOLI 172 1 -
AQTEPVLEYYRKKGV N_1AK3A 171 1 -
TQTTPLVEYYSKRGI KAD2_BOVIN 192 1 -
Final Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
VLLGPPGAGKGTQA KAD2_HUMAN 18 18 -
VLLGPPGAGKGTQA KAD2_RAT 18 18 -
VFLGPPGAGKGTQA O66490 4 4 -
VLLGPPGAGKGTQA KAD2_BOVIN 19 19 -
IFLGPPGAGKGTQA O29581 4 4 -
ILLGAPGAGKGTQA KAD_ECOLI 3 3 -
ILLGAPGAGKGTQA KAD_SALTY 4 4 -
VLVGPPGAGKGTQA KAD_STRCO 4 4 -
IFIGPPGSGKGTQA KADX_CAEEL 30 30 -
FVVGGPGSGKGTQC KAD1_PIG 12 12 -
FVVGGPGSGKGTQC KAD1_BOVIN 12 12 -
FVVGGPGSGKGTQC KAD1_RABIT 12 12 -
LLLGAPGAGKGTQA KAD_NEIGO 4 4 -
LLLGAPGAGKGTQA KAD_NEIME 4 4 -
ILLGAPGAGKGTQA KAD_HAEIN 4 4 -
FVVGGPGSGKGTQC KAD1_CHICK 13 13 -
FVVGGPGSGKGTQC KAD1_HUMAN 12 12 -
ILVGPPGSGKGTQS KADB_ORYSA 34 34 -
ILVGPPGAGKGTQA KAD1_SCHPO 7 7 -
ILLGAPGAGKGTQA O69172 4 4 -
LLLGAPGAGKGTQA KAD_NEIMU 4 4 -
VLIGPPGAGKGTQA KAD1_YEAST 9 9 -
FVVGGPGSGKGTQC KAD_CYPCA 11 11 -
ILLGPPGAGKGTQA KAD_BORPE 4 4 -
VLMGLPGAGKGTQG KAD_BACSU 4 4 -
ILLGAPGAGKGTQA KAD_YEREN 4 4 -
ILVGPPGCGKGTQS KADA_ORYSA 32 32 -
IFIGPPGSGKGTQS O82514 37 37 -
ILLGPPGAGKGTQA KAD_PARDE 5 5 -
VLMGLPGAGKGTQA KAD_BACST 4 4 -
IFLGAPGSGKGTQA P73302 8 8 -
LLLGAPGSGKGTQT KAD2_YEAST 18 18 -
AIMGAPGSGKGTVS KAD3_BOVIN 9 9 -
FVLGGPGAGKGTQC O59845 29 29 -
FIVGGPGSGKGTQC Q20140 24 24 -
VIMGAPGSGKGTGS KAD3_RAT 10 10 -
VFLGPPGSGKGTIS O51378 4 4 -
IFLGPPGAGKGTQA O24706 5 5 -
FVLGGPGSGKGTQC UMPK_ARATH 18 18 -
FVLGGPGSGKGTQC KAD_PRUAR 51 51 -
VFLGCPGVGKGTYA O80954 68 68 -
LLMGPPGSGKGTQA KAD_MICLU 5 5 -
LIMGLPGAGKGTQA KAD_LACLA 4 4 -
VFLGPPGAGKGTLA KAD_TREPA 4 4 -
IIMGAPGSGKGTQS O84130 9 9 -
VFFGPPGVGKGTQA KADH_TRIVA 19 19 -
LLLGPPGAGKGTQA O53796 4 4 -
FVLGGPGSGKGTQC KAD_SCHMA 13 13 -
MLLGAPGCGKGTQA KAD_MYCCA 4 4 -
FVLGGPGSGKGTQC KCY_DICDI 10 10 -
LIFGPPGSGKSTQA O58844 4 4 -
FVLGGPGAGKGTQC UMPK_YEAST 20 20 -
FVLGPPGSGKGTIC Q20230 6 6 -
VILGPPGSGKGTVC KAD3_HUMAN 9 9 -
FVLGPPGSGKGTIC O17622 6 6 -
VLLGPPGAGKGTQA O33007 4 4 -
FVLGGPGAGKGTQC KCY_PIG 7 7 -
LFLGAPGVGKGTLA KAD_MYCPN 8 8 -
LLSGAAGSGKGTIA KADY_CAEEL 5 5 -

Motif 2 width=15
Element Seqn Id St Int Rpt
GDMLRAMVASGSELG KAD2_HUMAN 46 14 -
GDMLRAMVASGSELG KAD2_RAT 46 14 -
GDILREAVQKGTPLG O66490 32 14 -
GDMLRAMVASGSELG KAD2_BOVIN 47 14 -
GDMLREAVAKGTELG O29581 32 14 -
GDMLRAAVKSGSELG KAD_ECOLI 31 14 -
GDMLRAAVKSGSELG KAD_SALTY 32 14 -
GDLFRANISQQTELG KAD_STRCO 32 14 -
GDLLRAEVASGSEFG KADX_CAEEL 58 14 -
GDLLRAEVSSGSARG KAD1_PIG 40 14 -
GDLLRAEVSSGSARG KAD1_BOVIN 40 14 -
GDLLRAEVSSGSARG KAD1_RABIT 40 14 -
GDMLRAAIKAGTPLG KAD_NEIGO 32 14 -
GDMLRAAIKAGTPLG KAD_NEIME 32 14 -
GDMFRAAIKAGTELG KAD_HAEIN 32 14 -
GDLLRAEVSSGSERG KAD1_CHICK 41 14 -
GDLLRSEVSSGSARG KAD1_HUMAN 40 14 -
GDMLRAAVAAKTPLG KADB_ORYSA 62 14 -
GDMLRSQVARQTELG KAD1_SCHPO 35 14 -
GDMLRAAVKAGSELG O69172 32 14 -
GDMLRAAIKAGAPLG KAD_NEIMU 32 14 -
GDMLRSQIAKGTQLG KAD1_YEAST 37 14 -
GDLLRAEVASGSERG KAD_CYPCA 39 14 -
GDMLRAAVKAGTPLG KAD_BORPE 32 14 -
GDMFRAAMKEETPLG KAD_BACSU 32 14 -
GDMLRAAVKAGSELG KAD_YEREN 32 14 -
GDMLRAAVAAKTPLG KADA_ORYSA 60 14 -
GDMLRAAVASKTPLG O82514 65 14 -
GDMLREARSSGTEMG KAD_PARDE 33 14 -
GDMFRAAMKEGTPLG KAD_BACST 32 14 -
GDMLRQAIADGTELG P73302 36 14 -
GDILRQEIKSESTLG KAD2_YEAST 47 15 -
GDLLRDNMLRGTEIG KAD3_BOVIN 37 14 -
GDLLRAEQHREGSEY O59845 57 14 -
GDLLRDEVKSGSPRG Q20140 52 14 -
GDLLRQNMLQGTEIA KAD3_RAT 38 14 -
GDLFRENILNSTALG O51378 32 14 -
GELLRAAVTAQTPLG O24706 33 14 -
GDLLRAEIKSGSENG UMPK_ARATH 46 14 -
GDLLRREIASGSAYG KAD_PRUAR 79 14 -
GDLVREELSSSGLLS O80954 96 14 -
GDIFRHNVKSMTPLG KAD_MICLU 33 14 -
GDMFRAAMKNETEMG KAD_LACLA 32 14 -
GGILRAAIQKQTALG KAD_TREPA 32 14 -
GDLLRDAVSKDTPLS O84130 37 14 -
GDALRAEIRGQTPLG KADH_TRIVA 47 14 -
GELFRRNIEEGTKLG O53796 32 14 -
GDLLRAEVQSGSPKG KAD_SCHMA 41 14 -
GDLMRKEISLNTTLG KAD_MYCCA 32 14 -
GDLLRQEQQSGSKDG KCY_DICDI 38 14 -
GDIIRAEISSRTPLG O58844 32 14 -
GDLLRAEQGRAGSQY UMPK_YEAST 48 14 -
GDLLRAERQREGSEF Q20230 34 14 -
GHFLRENIKASTEVG KAD3_HUMAN 37 14 -
GDLLRAERERAGSEY O17622 34 14 -
GELFRRNIEKDTKLG O33007 32 14 -
GELLRDERKNPDSQY KCY_PIG 35 14 -
GDIFRSVMQEQGALS KAD_MYCPN 36 14 -
GDFIRDHIARGTEFG KADY_CAEEL 36 17 -

Motif 3 width=17
Element Seqn Id St Int Rpt
FLLDGFPRTVRQAEMLD KAD2_HUMAN 95 34 -
FLLDGFPRTVKQAEMLD KAD2_RAT 95 34 -
VIFDGFPRTVKQAEALD O66490 78 31 -
FLLDGFPRTVRQAEMLD KAD2_BOVIN 96 34 -
FILDGFPRTLAQAEALD O29581 81 34 -
FLLDGFPRTIPQADAMK KAD_ECOLI 80 34 -
FLLDGFPRTIPQADAMK KAD_SALTY 81 34 -
FLLDGFPRNVSQAEALD KAD_STRCO 81 34 -
FILDGFPRTSGQAEKLD KADX_CAEEL 107 34 -
FLIDGYPREVKQGEEFE KAD1_PIG 90 35 -
FLIDGYPRQVQQGEEFE KAD1_BOVIN 90 35 -
FLIDGYPRQVQQGEEFE KAD1_RABIT 90 35 -
FLFDGFPRTLAQAEAMV KAD_NEIGO 81 34 -
FLFDGFPRTLAQAEAMV KAD_NEIME 81 34 -
FLLDGFPRTIPQADALK KAD_HAEIN 81 34 -
FLIDGYPREVKQGEEFE KAD1_CHICK 91 35 -
FLIDGYPREVQQGEEFE KAD1_HUMAN 90 35 -
FILDGFPRTVVQAQKLD KADB_ORYSA 111 34 -
FILDGFPRTVVQAEKLT KAD1_SCHPO 85 35 -
FLLDGFPRTIPQADAMK O69172 81 34 -
FLFDGFPRTLAQAEAMV KAD_NEIMU 81 34 -
FILDGFPRTIPQAEKLD KAD1_YEAST 87 35 -
YLIDGYPREVKQGEEFE KAD_CYPCA 89 35 -
YLFDGFPRTIPQADALK KAD_BORPE 81 34 -
FLLDGFPRTVAQAEALE KAD_BACSU 81 34 -
FLLHGFPRTIPQADAMK KAD_YEREN 81 34 -
FILDGFPRTVVQAQKLD KADA_ORYSA 109 34 -
FILDGFPRTVTQAEKLD O82514 114 34 -
FIFDGFPRTLAQADALQ KAD_PARDE 80 32 -
FLLDGFPRTVAQAEALE KAD_BACST 81 34 -
WILDGFPRNVNQAIFLD P73302 85 34 -
WLLDGFPRTTAQASALD KAD2_YEAST 99 37 -
WLLDGFPRTLPQAEALD KAD3_BOVIN 85 33 -
FLIDGFPRKMDQAEKFE O59845 118 46 -
FLIDGYPREVAQGQQFE Q20140 103 36 -
WLLDGFPRTLPQAEALD KAD3_RAT 86 33 -
FILDGFPRNICQAEALD O51378 81 34 -
WILDGFPRNRSQAEALN O24706 82 34 -
FLIDGFPRNEENRAAFE UMPK_ARATH 94 33 -
FLIDGFPRSEENRKAFE KAD_PRUAR 127 33 -
YILDGFPRTVTQAEILE O80954 147 36 -
FLLDGYPRTKGQVEALD KAD_MICLU 82 34 -
FLLDGYPRTIDQAHALD KAD_LACLA 82 35 -
FILDGFPRTVTQARCLE KAD_TREPA 81 34 -
AILDGFPRTVTQAKLLH O84130 99 47 -
YIFDGIPRTIGQVEKLD KADH_TRIVA 96 34 -
FILDGYPRSVEQAKALH O53796 81 34 -
SLSIRYPRELDQGIKFE KAD_SCHMA 91 35 -
LIFDGYPRTLEQAKLLE KAD_MYCCA 79 32 -
FLVDGFPRNEENNNSWE KCY_DICDI 86 33 -
FIMDGYPRTPEQVIALE O58844 79 32 -
FLIDGFPRKMDQAISFE UMPK_YEAST 100 37 -
FLVDGFPRNEDNLQGWN Q20230 84 35 -
WLLDGFPRTLGQAEALD KAD3_HUMAN 85 33 -
FLIDGFPRNEDNWSGWN O17622 84 35 -
FILDGYPRSLEQAKALH O33007 81 34 -
FLIDGFPRNQDNLQGWN KCY_PIG 89 39 -
FILDGYPRTLNQLEFLQ KAD_MYCPN 87 36 -
VVLDGYPRNMSQLKMVE KADY_CAEEL 83 32 -

Motif 4 width=16
Element Seqn Id St Int Rpt
RSDDNEKALKIRLQAY KAD2_HUMAN 174 62 -
RSDDNEKALKTRLEAY KAD2_RAT 174 62 -
REDDKPEVIKKRLEVY O66490 150 55 -
RSDDNKKALKIRLEAY KAD2_BOVIN 175 62 -
RDDDKEETVRERYRVY O29581 160 62 -
RKDDQEETVRKRLVEY KAD_ECOLI 155 58 -
RKDDQEETVRKRLVEY KAD_SALTY 156 58 -
RDDDSEETVRKRLEVY KAD_STRCO 161 63 -
RSDDNEETLRKRLVQY KADX_CAEEL 186 62 -
RVDDNEETIKKRLETY KAD1_PIG 138 31 -
RVDDNEETIKKRLETY KAD1_BOVIN 138 31 -
RVDDNEETIKKRLETY KAD1_RABIT 138 31 -
RDDDKEETVKKRLAVY KAD_NEIGO 156 58 -
RDDDKEETVKKRLAVY KAD_NEIME 156 58 -
RADDKPETVLDRLAVY KAD_HAEIN 156 58 -
RVDDNEETIKKRLETY KAD1_CHICK 139 31 -
RVDDNEETIKKRLETY KAD1_HUMAN 138 31 -
RKDDTAEVLKSRLEAF KADB_ORYSA 190 62 -
RSDDNADALRKRLVTY KAD1_SCHPO 164 62 -
RKDDQEATVRKRLIEY O69172 156 58 -
RDDDKEETVKKRLAVY KAD_NEIMU 156 58 -
RSDDNADALKKRLAAY KAD1_YEAST 166 62 -
RSDDNEETIKKRLDLY KAD_CYPCA 137 31 -
RDDDREETVRHRLNVY KAD_BORPE 156 58 -
RADDNEETVSKRLEVN KAD_BACSU 160 62 -
RKDDQEATVRKRLVEY KAD_YEREN 156 58 -
RKDDTAAVLKSRLEAF KADA_ORYSA 188 62 -
RKDDNADVLKSRLAAF O82514 193 62 -
RADDNEESLKTRLMEY KAD_PARDE 160 63 -
RADDNEATVANRLEVN KAD_BACST 160 62 -
RADDNETTIRNRLLVY P73302 133 31 -
RLDDTAEVFKKRLEEY KAD2_YEAST 178 62 -
REDDRPETVVKRLKAY KAD3_BOVIN 159 57 -
REDDNVESIKKRFNTY O59845 166 31 -
RADDNADTIKKRLHTF Q20140 151 31 -
REDDKPETVIKRLKAY KAD3_RAT 160 57 -
REDDKEECLKTRLKEY O51378 155 57 -
RADDTESVIRRRLEVY O24706 130 31 -
REDDNIETIRKRFKVF UMPK_ARATH 141 30 -
RVDDNIDTIKKRLEIF KAD_PRUAR 174 30 -
RADDTEEVVKERLRIY O80954 232 68 -
RADDTQEVIEHRLDLY KAD_MICLU 134 35 -
RADDVPETVKNRLDVN KAD_LACLA 162 63 -
REDDKMSAILQRLTAY KAD_TREPA 155 57 -
RSDDTLEVILDRIQTY O84130 173 57 -
RKDDTPEVFNQRMNQY KADH_TRIVA 175 62 -
RADDTDDVILNRMKVY O53796 129 31 -
RVDDNEETIVKRFRTF KAD_SCHMA 139 31 -
RSDDSLDKVKIRLQTY KAD_MYCCA 158 62 -
RSDDNIESIKKRFNTF KCY_DICDI 137 34 -
RPDDRPEIVEKRYDIY O58844 158 62 -
RSDDNIESIKKRFNTF UMPK_YEAST 148 31 -
RTDDNEESLKKRVETY Q20230 133 32 -
QEDDKPEAVAARLRQY KAD3_HUMAN 159 57 -
RTDDNVESLKKRVETY O17622 133 32 -
RADDTDDVVINRMNIY O33007 129 31 -
RSDDNRESLEKRIQTY KCY_PIG 140 34 -
RNDDTEAVILKRLTLY KAD_MYCPN 162 58 -
RSTDQLEVARRRLEVY KADY_CAEEL 157 57 -

Motif 5 width=15
Element Seqn Id St Int Rpt
TQTTPLIEYYRKRGI KAD2_HUMAN 191 1 -
TQTTPLVEYYRKRGI KAD2_RAT 191 1 -
EQTAPLIEYYKKKGI O66490 167 1 -
TQTTPLVEYYSKRGI KAD2_BOVIN 192 1 -
QNTEPLIDYYRKKGI O29581 177 1 -
QMTAPLIGYYSKEAE KAD_ECOLI 172 1 -
QMTAPLIGYYQKEAE KAD_SALTY 173 1 -
TQTEPIIDYYKSQGL KAD_STRCO 178 1 -
QMTVPLVDYYKKHGV KADX_CAEEL 203 1 -
KATEPVIAFYEKRGI KAD1_PIG 155 1 -
KATEPVIAFYEKRGI KAD1_BOVIN 155 1 -
KATEPVIAFYEKRGI KAD1_RABIT 155 1 -
EQTEVLVDFYSKLEG KAD_NEIGO 173 1 -
EQTEVLVDFYSKLEG KAD_NEIME 173 1 -
KQTSPLIDYYQAEAK KAD_HAEIN 173 1 -
KATEPVIAFYKGRGI KAD1_CHICK 156 1 -
KATEPVIAFYEKRGI KAD1_HUMAN 155 1 -
KQTEPVIDYYSKKAL KADB_ORYSA 207 1 -
EQTTPVVEFYKKKGK KAD1_SCHPO 181 1 -
QQTAPLVSYYHKEAD O69172 173 1 -
EQTEVLVDFYSKLEG KAD_NEIMU 173 1 -
AQTEPIVDFYKKTGI KAD1_YEAST 183 1 -
KATEPVIAYYETRGI KAD_CYPCA 154 1 -
NQTRPLVDYYSSWAQ KAD_BORPE 173 1 -
KQTQPLLDFYSEKGY KAD_BACSU 177 1 -
QQTAPLVSYYRKEAD KAD_YEREN 173 1 -
VQTKPVIDYYTKKGI KADA_ORYSA 205 1 -
SQTQPVIDYYAKKAV O82514 210 1 -
KKTSPLIGYYYVKGN KAD_PARDE 177 1 -
KQMKPLVDFYEQKGY KAD_BACST 177 1 -
EQTAPLMAYYQEQGK P73302 150 1 -
KTNEPLKDYYKKSGI KAD2_YEAST 195 1 -
AQTEPVLEYYRKKGV KAD3_BOVIN 176 1 -
EQTMPVIEHYEKLGK O59845 183 1 -
TSTAPVVDYYESKGK Q20140 168 1 -
AQTEPVLQYYQKKGV KAD3_RAT 177 1 -
LQTKPLIEFYSKCSR O51378 172 1 -
EQTAPLIDFFRDRQQ O24706 147 1 -
ESSLPVIHYYEAKGK UMPK_ARATH 158 1 -
ELNWPVINYYSQRGK KAD_PRUAR 191 1 -
KMTQPVEEFYKKRGK O80954 249 1 -
RETESVIQEYVERGI KAD_MICLU 151 1 -
KESAPIIEHYTELGL KAD_LACLA 179 1 -
AQAEPIVHFYSERGK KAD_TREPA 172 1 -
QETQPVLDYYTEKQK O84130 190 1 -
GTFQPCIDYYSKKGI KADH_TRIVA 192 1 -
DETAPLLEYYRDQLK O53796 146 1 -
ELTKPVIEHYKQQNK KAD_SCHMA 156 1 -
EQTLPLIDYFKTNSK KAD_MYCCA 175 1 -
VQTKLVIDHYNKFDK KCY_DICDI 154 1 -
RNMEPIIKFYQKQGI O58844 175 1 -
ETSMPVIEYFETKSK UMPK_YEAST 165 1 -
QQTFPIIEHFEKSGL Q20230 150 1 -
DVAKPVIELYKSRGV KAD3_HUMAN 176 1 -
QSTFPIIEHFEKVGM O17622 150 1 -
DETRSLLEYYSSELK O33007 146 1 -
QSTKPIIDLYEEMGK KCY_PIG 157 1 -
DTVKPLIEAFTKQGI KAD_MYCPN 179 1 -
KTENKVLDYYKKQNK KADY_CAEEL 174 1 -