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PR00092

Identifier
TYROSINASE  [View Relations]  [View Alignment]  
Accession
PR00092
No. of Motifs
4
Creation Date
01-AUG-1991  (UPDATE 27-JUN-1999)
Title
Tyrosinase copper-binding domain signature
Database References

PROSITE; PS00497 TYROSINASE_1; PS00498 TYROSINASE_2
PFAM; PF00264 tyrosinase
INTERPRO; IPR002227
Literature References
1. MULLER, G., RUPPERT, S., SCHMID, E. AND SCHUTZ, G.
Functional analysis of alternatively spliced tyrosinase gene transcripts.
EMBO J. 8 2723-2730 (1988).
 
2. LANG, W.H.
cDNA Cloning of the OCTOPUS DOFLEINI haemocyanin: sequence of the
carboxy-terminal domain.
BIOCHEMISTRY 27 7276-7282 (1988).

Documentation
Tyrosinase (monophenol oxygenase) [EC 1.14.18.1] is a copper monooxygenase
that catalyses the hydroxylation of monophenols, and the oxidation of
o-diphenols to o-quinols. These reactions make it a key enzyme in the
formation of pigments such as melanin in both prokaryotes and eukaryotes.
The protein binds 2 copper ions (designated CuA and CuB), each being bound 
by 3 conserved His residues [1]. This is reminiscent of copper binding in 
haemocyanins (copper-containing oxygen carriers found in molluscan and 
arthropodan haemolymph) [2], the second ion-binding site in both proteins 
showing the greatest degree of similarity [1,2]. 
 
It is believed that molluscan and arthropodan haemocyanins have evolved 
independently from a common ancestral copper-containing protein: it has 
been hypothesised [2] that gene duplication may have led to the evolution 
of the arthropod haemocyanins, while fusion with a gene of a different 
structure led to the evolution of tyrosinases and molluscan haemocyanins. 
This hypothesis is partially verified by the fact that although the 2 types
of haemocyanin have similar amino-acid compositions, they vary markedly in 
sequence and structure, the only real sequence similarity being in the 
second copper-binding domain.
 
TYROSINASE is a 4-element fingerprint that provides a signature for copper-
binding motifs in tyrosinases. The fingerprint was derived from an initial
alignment of 5 sequences: motif 1 includes the highly conserved WHR motif,
the His of which binds copper in the first binding site (CuA) (cf. PROSITE
pattern TYROSINASE_1 (PS00497)); and motifs 3 and 4 encode the second
copper-binding domain (CuB) (cf. PROSITE pattern TYROSINASE_2 (PS00498)).
Three iterations on OWL12.0 were required to reach convergence, at which
point a true set comprising 19 sequences was identified, including a number
of molluscan haemocyanins. A subfamily of arthropodan haemocyanins was
found to match just 2 motifs. 
 
An update on SPTR37_9f identified a true set of 49 sequences, and 2
partial matches.
Summary Information
49 codes involving  4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
449494949
30000
20000
1234
True Positives
O01497        O24056        O24057        O42713        
O49960 O57405 O76708 O81103
O93505 P93622 PPOA_LYCES PPOB_LYCES
PPOC_LYCES PPOD_LYCES PPOE_LYCES PPOF_LYCES
PPO_MALDO PPO_SPIOL PPO_VICFA PPO_VITVI
Q00024 Q15675 Q15679 Q15680
Q40774 Q41388 Q41427 Q41428
Q91436 TYR1_CARAU TYR1_HUMAN TYR1_MOUSE
TYR2_HUMAN TYR2_MOUSE TYRO_ASPOR TYRO_CHICK
TYRO_HUMAN TYRO_MOUSE TYRO_NEUCR TYRO_ORYLA
TYRO_PODAN TYRO_RANNI TYRO_RHIME TYRO_STRAL
TYRO_STRAT TYRO_STRGA TYRO_STRLN YKH1_CAEEL
YTQJ_CAEEL
Sequence Titles
O01497      SIMILAR TO THE TYROSINASE FAMILY - CAENORHABDITIS ELEGANS. 
O24056 POLYPHENOL OXIDASE PRECURSOR (EC 1.10.3.1) - MALUS DOMESTICA (APPLE) (MALUS SYLVESTRIS).
O24057 POLYPHENOL OXIDASE PRECURSOR (EC 1.10.3.1) - MALUS DOMESTICA (APPLE) (MALUS SYLVESTRIS).
O42713 TYROSINASE 2 (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) (PHENOLASE) (MONOPHENOL OXIDASE) (CRESOLASE) - AGARICUS BISPORUS (COMMON MUSHROOM).
O49960 POLYPHENOL OXIDASE - SACCHARUM HYBRID (SUGARCANE).
O57405 TYROSINASE-RELATED PROTEIN-1 PRECURSOR - GALLUS GALLUS (CHICKEN).
O76708 Y44E3B.2 PROTEIN - CAENORHABDITIS ELEGANS.
O81103 POLYPHENOL OXIDASE PRECURSOR - PRUNUS ARMENIACA (APRICOT).
O93505 TYROSINASE-RELATED PROTEIN-2 - GALLUS GALLUS (CHICKEN).
P93622 POLYPHENOL OXIDASE (EC 1.10.3.1) (CATECHOL OXIDASE) (DIPHENOL OXIDASE) (O-DIPHENOLASE) (PHENOLASE) (TYROSINASE) - VITIS VINIFERA (GRAPE).
PPOA_LYCES POLYPHENOL OXIDASE A PRECURSOR (EC 1.10.3.1) (PPO) (CATECHOL OXIDASE) - LYCOPERSICON ESCULENTUM (TOMATO).
PPOB_LYCES POLYPHENOL OXIDASE B PRECURSOR (EC 1.10.3.1) (PPO) (CATECHOL OXIDASE) - LYCOPERSICON ESCULENTUM (TOMATO).
PPOC_LYCES POLYPHENOL OXIDASE C PRECURSOR (EC 1.10.3.1) (PPO) (CATECHOL OXIDASE) - LYCOPERSICON ESCULENTUM (TOMATO).
PPOD_LYCES POLYPHENOL OXIDASE D PRECURSOR (EC 1.10.3.1) (PPO) (CATECHOL OXIDASE) - LYCOPERSICON ESCULENTUM (TOMATO).
PPOE_LYCES POLYPHENOL OXIDASE E PRECURSOR (EC 1.10.3.1) (PPO) (CATECHOL OXIDASE) - LYCOPERSICON ESCULENTUM (TOMATO).
PPOF_LYCES POLYPHENOL OXIDASE F PRECURSOR (EC 1.10.3.1) (PPO) (CATECHOL OXIDASE) - LYCOPERSICON ESCULENTUM (TOMATO).
PPO_MALDO POLYPHENOL OXIDASE PRECURSOR (EC 1.10.3.1) (PPO) (CATECHOL OXIDASE) - MALUS DOMESTICA (APPLE) (MALUS SYLVESTRIS).
PPO_SPIOL POLYPHENOL OXIDASE PRECURSOR (EC 1.10.3.1) (PPO) (CATECHOL OXIDASE) - SPINACIA OLERACEA (SPINACH).
PPO_VICFA POLYPHENOL OXIDASE A1 PRECURSOR (EC 1.10.3.1) (PPO) (CATECHOL OXIDASE) - VICIA FABA (BROAD BEAN).
PPO_VITVI POLYPHENOL OXIDASE PRECURSOR (EC 1.10.3.1) (PPO) (CATECHOL OXIDASE) - VITIS VINIFERA (GRAPE).
Q00024 TYROSINASE 1 (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) (PHENOLASE) (MONOPHENOL OXIDASE) (CRESOLASE) - AGARICUS BISPORUS (COMMON MUSHROOM).
Q15675 TYROSINASE - HOMO SAPIENS (HUMAN).
Q15679 TYROSINASE RELATED PROTEIN 1 (TRP-1) - HOMO SAPIENS (HUMAN).
Q15680 TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) - HOMO SAPIENS (HUMAN).
Q40774 POLYPHENOL OXIDASE - PHYTOLACCA AMERICANA (COMMON POKEBERRY) (VIRGINIAN POKEWEED).
Q41388 POLYPHENOL OXIDASE - SPINACIA OLERACEA (SPINACH).
Q41427 POLYPHENOL OXIDASE - SOLANUM TUBEROSUM (POTATO).
Q41428 POLYPHENOL OXIDASE - SOLANUM TUBEROSUM (POTATO).
Q91436 TYROSINASE - GALLUS GALLUS (CHICKEN).
TYR1_CARAU 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID OXIDASE PRECURSOR (EC 1.14.18.-) (DHICA OXIDASE) (TYROSINASE-RELATED PROTEIN 1) (TRP-1) (TRP1) - CARASSIUS AURATUS (GOLDFISH).
TYR1_HUMAN 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID OXIDASE PRECURSOR (EC 1.14.18.-) (DHICA OXIDASE) (TYROSINASE-RELATED PROTEIN 1) (TRP-1) (TRP1) (TRP) (CATALASE B) (GLYCOPROTEIN-75) (GP75) - HOMO SAPIENS (HUMAN).
TYR1_MOUSE 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID OXIDASE PRECURSOR (EC 1.14.18.-) (DHICA OXIDASE) (TYROSINASE-RELATED PROTEIN 1) (TRP-1) (TRP1) (TRP) (CATALASE B) (BROWN LOCUS PROTEIN) - MUS MUSCULUS (MOUSE).
TYR2_HUMAN DOPACHROME TAUTOMERASE PRECURSOR (EC 5.3.3.12) (DT) (DCT) (DOPACHROME DELTA-ISOMERASE) (TYROSINASE-RELATED PROTEIN 2) (TRP-2) (TRP2) - HOMO SAPIENS (HUMAN).
TYR2_MOUSE DOPACHROME TAUTOMERASE PRECURSOR (EC 5.3.3.12) (DT) (DCT) (DOPACHROME DELTA-ISOMERASE) (TYROSINASE-RELATED PROTEIN 2) (TRP-2) (TRP2) (SLATY LOCUS PROTEIN) - MUS MUSCULUS (MOUSE).
TYRO_ASPOR TYROSINASE (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) - ASPERGILLUS ORYZAE.
TYRO_CHICK TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) - GALLUS GALLUS (CHICKEN).
TYRO_HUMAN TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) - HOMO SAPIENS (HUMAN).
TYRO_MOUSE TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) (ALBINO LOCUS PROTEIN) - MUS MUSCULUS (MOUSE).
TYRO_NEUCR TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) - NEUROSPORA CRASSA.
TYRO_ORYLA TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) - ORYZIAS LATIPES (MEDAKA FISH).
TYRO_PODAN TYROSINASE (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) - PODOSPORA ANSERINA.
TYRO_RANNI TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) - RANA NIGROMACULATA (JAPANESE POND FROG).
TYRO_RHIME TYROSINASE (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) - RHIZOBIUM MELILOTI.
TYRO_STRAL TYROSINASE (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) - STREPTOMYCES ALBUS G.
TYRO_STRAT TYROSINASE (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) - STREPTOMYCES ANTIBIOTICUS.
TYRO_STRGA TYROSINASE (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) - STREPTOMYCES GLAUCESCENS.
TYRO_STRLN TYROSINASE (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) - STREPTOMYCES LINCOLNENSIS.
YKH1_CAEEL HYPOTHETICAL TYROSINASE-LIKE PROTEIN C02C2.1 IN CHROMOSOME III - CAENORHABDITIS ELEGANS.
YTQJ_CAEEL HYPOTHETICAL TYROSINE-LIKE PROTEIN F21C3.2 IN CHROMOSOME I - CAENORHABDITIS ELEGANS.
Scan History
OWL12_0    3  150  NSINGLE    
OWL17_1 1 100 NSINGLE
OWL18_0 1 105 NSINGLE
OWL19_1 1 120 NSINGLE
SPTR37_9f 3 97 NSINGLE
Initial Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
HEAPGFLPWHRLFLLLWE MUSTYROS 202 202 -
HSSILFITWHRPYLALYE NEUTYRA 97 97 -
HRSPSFLPWHRRYLLEFE TYRO_STRGA 53 53 -
HRSPSFLPWHRRFLLEFE TYRO_STRAT 53 53 -
HEAPAFLPWHRLFLLRWE TYRO_HUMAN 202 202 -

Motif 2 width=6
Element Seqn Id St Int Rpt
LPYWDW TYRO_STRGA 82 11 -
APYFDW NEUTYRA 147 32 -
VPYWDW MUSTYROS 233 13 -
IPYWDW TYRO_HUMAN 233 13 -
LPYWDW TYRO_STRAT 82 11 -

Motif 3 width=12
Element Seqn Id St Int Rpt
MHNALHIFMNGT MUSTYROS 362 123 -
LHNRVHVWVGGQ TYRO_STRGA 188 100 -
LHNRVHVWVGGQ TYRO_STRAT 188 100 -
MHNALHIYMNGT TYRO_HUMAN 362 123 -
VHNEIHDRTGGN NEUTYRA 277 124 -

Motif 4 width=19
Element Seqn Id St Int Rpt
FDPLFWLHHVNVDRLWSIW NEUTYRA 299 10 -
NDPIFLLHHAFVDSIFEQW TYRO_HUMAN 382 8 -
NDPVFWLHHAYIDKLWAEW TYRO_STRAT 207 7 -
NDPVFWLHNAYVDKLWAEW TYRO_STRGA 207 7 -
NDPIFLLHHAFVDSIFEQW MUSTYROS 382 8 -
Final Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
HRSPSFLPWHRRYLLEFE TYRO_STRGA 53 53 -
HFSWLFFPFHRWYLYFYE PPOE_LYCES 197 197 -
HFSWLFFPFHRWYLYFYE PPOF_LYCES 197 197 -
HNSWLFFPFHRWYLYFYE PPOD_LYCES 194 194 -
HRSPSFLPWHRRFLLEFE TYRO_STRAT 53 53 -
HFSWLFFPFHRMYLYFYE O81103 209 209 -
HNSWLFFPFHRWYLYFHE Q41427 200 200 -
HNSWLFFPFHRWYLYFYE PPOB_LYCES 199 199 -
HNSWLFFPFHRWYLYFYE Q41428 202 202 -
HRSPSFLPWHRRFLLEFE TYRO_STRLN 52 52 -
HASWLFLPFHRYYLYFNE PPO_VITVI 211 211 -
HNSWLFFPFHRYYLYFFE PPO_MALDO 196 196 -
HNSWLFFPFHRWYLYFYE PPOA_LYCES 198 198 -
HNSWLFFPFHRWYLYFYE PPOC_LYCES 194 194 -
HNSWLFFPFHRYYLYFCE O24056 196 196 -
HASWLFPSFHRWYLYFYE PPO_SPIOL 214 214 -
HASWLFPSFHRWYLYFYE Q41388 214 214 -
HEAPAFLPWHRLFLLRWE Q15675 204 204 -
HEAPAFLPWHRLFLLRWE Q15680 202 202 -
HEAPAFLPWHRLFLLRWE TYRO_HUMAN 202 202 -
HEAPGFLPWHRLFLLLWE TYRO_MOUSE 202 202 -
HEAPGFLPWHRAFLLLWE Q91436 202 202 -
HEAPGFLPWHRAFLLLWE TYRO_CHICK 202 202 -
HGDWWFTSWHRGYLGYFE TYRO_RHIME 44 44 -
HESAAFLPWHRVYLLHWE TYRO_ORYLA 205 205 -
HNSWLFFPLHRYYLYFFE O24057 196 196 -
RLPLPFLPWHRRFLLDFE TYRO_STRAL 56 56 -
HASWLFLPFHRYYLYFNE P93622 211 211 -
HEGPAFLTWHRYHLLRLE Q15679 215 215 -
HEGPAFLTWHRYHLLRLE TYR1_HUMAN 215 215 -
HGSWLFFPFHRWYLYFYE PPO_VICFA 202 202 -
HEGPAFLTWHRYHLLQLE TYR1_MOUSE 215 215 -
HEGPGFLTWHRYHLLQLE TYR1_CARAU 205 205 -
HEAPGFLPWHRFYLLLWE TYRO_RANNI 206 206 -
HQGPAFVTWHRYHLLCLE TYR2_HUMAN 211 211 -
HEGPAFVTWHRYHLLQLE O57405 214 214 -
HFSWLFFPFHRFYLYFFE Q40774 201 201 -
HQGPAFVTWHRYHLLLLE O93505 213 213 -
HSGPAFLPWHREFVKRVE O01497 154 154 -
HQGPAFVTWHRYHLLWLE TYR2_MOUSE 211 211 -
HGSTLFPTWHRPYVLILE Q00024 85 85 -
HYSWIFAPWHRMYIYFYE O49960 198 198 -
HGNILFPTWHRAYLMAVE TYRO_ASPOR 84 84 -
HSSILFITWHRPYLALYE TYRO_NEUCR 96 96 -
HSSILFLTWHRPYLALFE TYRO_PODAN 95 95 -
HSGPGFLVWHREYMKRME YKH1_CAEEL 41 41 -
HGQVLFPTWHRTYLSVLE O42713 81 81 -
HSGPAFLPWHREFVDPSL YTQJ_CAEEL 283 283 -
HSGPAFTLWHREFLKRLE O76708 77 77 -

Motif 2 width=6
Element Seqn Id St Int Rpt
LPYWDW TYRO_STRGA 82 11 -
LPYWNW PPOE_LYCES 228 13 -
LPYWNW PPOF_LYCES 228 13 -
LPYWNW PPOD_LYCES 225 13 -
LPYWDW TYRO_STRAT 82 11 -
LPYWNW O81103 240 13 -
LPYWNW Q41427 231 13 -
LPYWNW PPOB_LYCES 230 13 -
LPYWNW Q41428 233 13 -
LPYWDW TYRO_STRLN 81 11 -
LPYWAW PPO_VITVI 242 13 -
LPFWNW PPO_MALDO 227 13 -
LPFWNW PPOA_LYCES 229 13 -
LPFWNW PPOC_LYCES 225 13 -
LPFWNW O24056 227 13 -
LPYWNW PPO_SPIOL 245 13 -
LPYWNW Q41388 245 13 -
IPYWDW Q15675 235 13 -
IPYWDW Q15680 233 13 -
IPYWDW TYRO_HUMAN 233 13 -
VPYWDW TYRO_MOUSE 233 13 -
IPYWDW Q91436 233 13 -
IPYWDW TYRO_CHICK 233 13 -
LPYWDW TYRO_RHIME 75 13 -
IPYWDW TYRO_ORYLA 236 13 -
GPFWNW O24057 227 13 -
LPYWDW TYRO_STRAL 85 11 -
LAYWAW P93622 242 13 -
LPYWNF Q15679 246 13 -
LPYWNF TYR1_HUMAN 246 13 -
LPFWNY PPO_VICFA 233 13 -
LPYWNF TYR1_MOUSE 246 13 -
LPYWDF TYR1_CARAU 236 13 -
IPFWDW TYRO_RANNI 237 13 -
LPYWNF TYR2_HUMAN 242 13 -
LPYWNF O57405 245 13 -
IPFWNW Q40774 232 13 -
LPYWDF O93505 244 13 -
LPYWDS O01497 183 11 -
LPYWNF TYR2_MOUSE 242 13 -
HPYWDW Q00024 132 29 -
LPFWSW O49960 229 13 -
LPYWDE TYRO_ASPOR 113 11 -
APYFDW TYRO_NEUCR 146 32 -
MPYFDW TYRO_PODAN 144 31 -
MPYWDS YKH1_CAEEL 70 11 -
QPYWDW O42713 128 29 -
LPYWDS YTQJ_CAEEL 302 1 -
LPFWDS O76708 108 13 -

Motif 3 width=12
Element Seqn Id St Int Rpt
LHNRVHVWVGGQ TYRO_STRGA 188 100 -
PHTPVHIWTGDK PPOE_LYCES 327 93 -
PHTPVHIWTGDS PPOF_LYCES 325 91 -
PHGPVHIWSGTV PPOD_LYCES 323 92 -
LHNRVHVWVGGQ TYRO_STRAT 188 100 -
PHNNIHIWVGDP O81103 340 94 -
PHGPVHIWSGTV Q41427 329 92 -
PHIPVHIWAGTV PPOB_LYCES 328 92 -
PHIPVHIWAGTV Q41428 331 92 -
LHNRVHVWVGGQ TYRO_STRLN 187 100 -
PHNIVHKWTGLA PPO_VITVI 341 93 -
PHAPVHLWTGDN PPO_MALDO 326 93 -
PHSPVHIWVGTR PPOA_LYCES 327 92 -
PHSPVHIWVGTR PPOC_LYCES 323 92 -
PHAPVHLWTGDN O24056 326 93 -
PHNSVHVWTRSN PPO_SPIOL 353 102 -
PHNSVHVWTRSN Q41388 353 102 -
MHNALHIYMNGT Q15675 365 124 -
MHNALHIYMNGT Q15680 362 123 -
MHNALHIYMNGT TYRO_HUMAN 362 123 -
MHNALHIFMNGT TYRO_MOUSE 362 123 -
LHNALHIYMNGS Q91436 362 123 -
LHNALHIYMNGS TYRO_CHICK 362 123 -
PHNRVHMSVGGQ TYRO_RHIME 223 142 -
MHNALHVFMNGS TYRO_ORYLA 365 123 -
PHAPVHLWTGDN O24057 326 93 -
LHNRVHVWVGGQ TYRO_STRAL 191 100 -
PHNIVHKWTGLA P93622 341 93 -
LHNLAHLFLNGT Q15679 376 124 -
LHNLAHLFLNGT TYR1_HUMAN 376 124 -
PHAPVHTWTGDN PPO_VICFA 332 93 -
LHNLAHLFLNGT TYR1_MOUSE 376 124 -
LHNLAHLFLNGT TYR1_CARAU 366 124 -
MHNSLHVFLNGS TYRO_RANNI 366 123 -
LHNLVHSFLNGT TYR2_HUMAN 368 120 -
LHNLAHLFLNGT O57405 375 124 -
PHGPVHVWTGDP Q40774 333 95 -
LHNLAHSFLNGT O93505 369 119 -
THGNVHIFVGGD O01497 281 92 -
LHNLAHSFLNGT TYR2_MOUSE 368 120 -
IHDNIHVLVGGN Q00024 256 118 -
AHTAMHVWVGKA O49960 336 101 -
PHNDMHLAIGGV TYRO_ASPOR 289 170 -
VHNEIHDRTGGN TYRO_NEUCR 276 124 -
VHNEIHDRTGGG TYRO_PODAN 274 124 -
THASIHLWMGGD YKH1_CAEEL 171 95 -
VHDDIHVMVGYG O42713 249 115 -
THGNPHIYVGGD YTQJ_CAEEL 401 93 -
SHDYVHFFVNGD O76708 213 99 -

Motif 4 width=19
Element Seqn Id St Int Rpt
NDPVFWLHNAYVDKLWAEW TYRO_STRGA 207 7 -
LDPIFYCHHANVDRMWNEW PPOE_LYCES 355 16 -
LDPLFYCHHANVDRMWNEW PPOF_LYCES 353 16 -
LDPVFFCHHSNVDRMWSEW PPOD_LYCES 358 23 -
NDPVFWLHHAYIDKLWAEW TYRO_STRAT 207 7 -
RDPLFYAHHANVDRMWNIW O81103 367 15 -
LDPVFFCHHSNVDRMWSEW Q41427 364 23 -
LDPVFYCHHGNVDRMWNEW PPOB_LYCES 363 23 -
LDPVFYCHHGNVDRMWNEW Q41428 366 23 -
NDPVFWLHHAYIDKLWAQW TYRO_STRLN 206 7 -
RDPIFFGHHANVDRMWNIW PPO_VITVI 367 14 -
RDPIFFAHHSNVDRMWSIW PPO_MALDO 353 15 -
LDPLFYCHHSNVDRMWNEW PPOA_LYCES 362 23 -
LDPLFYCHHSNVDRMWNEW PPOC_LYCES 358 23 -
RDPIFFAHHSNVDRMWSIW O24056 353 15 -
RDPLFYCHHSNVDRMWSLW PPO_SPIOL 380 15 -
RDPLFYCHHSNVDRMWSLW Q41388 380 15 -
NDPIFLLHHAFVDSIFEQW Q15675 385 8 -
NDPIFLLHHAFVDSIFEQW Q15680 382 8 -
NDPIFLLHHAFVDSIFEQW TYRO_HUMAN 382 8 -
NDPIFLLHHAFVDSIFEQW TYRO_MOUSE 382 8 -
NDPIFILHHAFVDSIFERW Q91436 382 8 -
NDPIFILHHAFVDSIFERW TYRO_CHICK 382 8 -
LDPIFFLHHCNIDRLWDVW TYRO_RHIME 248 13 -
NDPIFLLHHAFIDSIFERW TYRO_ORYLA 385 8 -
RDPIFFAHHSNVDRMWSIW O24057 353 15 -
NDPVFWLHHAYNRQLWAEW TYRO_STRAL 210 7 -
RDPIFFGHHANVDRMWNIW P93622 367 14 -
NDPIFVLLHTFTDAVFDEW Q15679 396 8 -
NDPIFVLLHTFTDAVFDEW TYR1_HUMAN 396 8 -
RDPIFYSHHSNVDRLWYIW PPO_VICFA 359 15 -
NDPIFVLLHTFTDAVFDEW TYR1_MOUSE 396 8 -
NDPIFVLLHTFTDAVFDEW TYR1_CARAU 386 8 -
NDPIFVLHHAFVDSLFEQW TYRO_RANNI 386 8 -
NDPIFVVLHSFTDAIFDEW TYR2_HUMAN 388 8 -
NDPIFVLLHTFTDAVFDEW O57405 395 8 -
RVPIFYAHHAIVDRMWAIW Q40774 360 15 -
NDPIFVVLHSFTDAIFDEW O93505 389 8 -
NDPSFFLHHAFIDFVWEEW O01497 301 8 -
NDPVFVVLHSFTDAIFDEW TYR2_MOUSE 388 8 -
FDPIFFLHHANVDRLIALW Q00024 278 10 -
NDPLFYSHHSNVDRMWHLW O49960 382 34 -
FDPIFYFHHCFIDYLFWTW TYRO_ASPOR 325 24 -
FDPLFWLHHVNVDRLWSIW TYRO_NEUCR 298 10 -
FDPLFWFHHTNVDRLWAIW TYRO_PODAN 296 10 -
NDPVFFLHHTFVDFIWEMW YKH1_CAEEL 191 8 -
FDPIFWLHHTNVDRLLSLW O42713 274 13 -
NDPIFWMHHSFVDLLWEMY YTQJ_CAEEL 421 8 -
NDVCFVYHHGMIDWIFEHW O76708 233 8 -