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PR00083

Identifier
HOLDHDRGNASE  [View Relations]  [View Alignment]  
Accession
PR00083
No. of Motifs
9
Creation Date
06-FEB-1995  (UPDATE 10-JUN-1999)
Title
Histidinol dehydrogenase signature
Database References

PROSITE; PS00611 HISOL_DEHYDROGENASE
PFAM; PF00815 Histidinol_dh
INTERPRO; IPR001692
UMBBD; e0432
Literature References
1. GRUBMEYER, C.T. AND GRAY, W.R.
A cysteine residue (cysteine-116) in the histidinol binding site of
histidinol dehydrogenase.
BIOCHEMISTRY 25 4778-4784 (1986).
 
2. LEGERTON, T.L. AND YANOFSKY, C.
Cloning and characterization of the multifunctional his-3 gene of
Neurospora crassa.
GENE 39 129-140 (1985).

Documentation
Histidinol dehydrogenase catalyses the final step in microbial histidine
biosynthesis, the 4-electron oxidation of L-histidinol to histidine [1]. In
4-electron dehydrogenases, a single active site catalyses 2 separate 
oxidation steps: oxidation of the substrate alcohol to an intermediate
aldehyde; and oxidation of the aldehyde to the product acid, in this case
His [1]. The reaction proceeds via a tightly- or covalently-bound inter-
mediate, and requires the presence of 2 NAD molecules [1]. By contrast with
most dehydrogenases, the substrate is bound before the NAD coenzyme [1]. A
Cys residue has been implicated in the catalytic mechanism of the second
oxidative step [1]. Bacterial histidinol dehydrogenase is a distinct single-
chain enzyme [1], but is part of a multifunctional enzyme in fungi [2].
 
HOLDHDRGNASE is a 9-element fingerprint that provides a signature for 
histidinol dehydrogenases. The fingerprint was derived from an initial
alignment of 5 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length, motif 2 including the region
encoded by PROSITE pattern HISOL_DEHYDROGENASE (PS00611), which contains
the catalytically important Cys. Two iterations on OWL25.1 were required
to reach convergence, at which point a true set comprising 12 sequences
was identified. Two partial matches were also found (S24815 and PPPPIC3K),
both of which are C-terminally truncated histidinol dehydrogenase fragments.
 
An update on SPTR37_9f identified a true set of 22 sequences, and 2
partial matches.
Summary Information
  22 codes involving  9 elements
0 codes involving 8 elements
0 codes involving 7 elements
1 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
1 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
9222222222222222222
8000000000
7000000000
6111111000
5000000000
4000000000
3000110100
2000000000
123456789
True Positives
HIS2_KLULA    HIS2_NEUCR    HIS2_PICPA    HIS2_SACBA    
HIS2_YEAST HISX_ARCFU HISX_BACSU HISX_BRAOC
HISX_ECOLI HISX_HAEIN HISX_LACLA HISX_METJA
HISX_METTH HISX_MYCSM HISX_MYCTU HISX_SALTY
HISX_STRCO HISX_SULSO HISX_SYNY3 O59626
O66976 O74712
True Positive Partials
Codes involving 6 elements
Q12201
Codes involving 3 elements
P72946
Sequence Titles
HIS2_KLULA  HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN [INCLUDES: PHOSPHORIBOSYL-AMP CYCLOHYDROLASE (EC 3.5.4.19); PHOSPHORIBOSYL-ATP PYROPHOSPHOHYDROLASE (EC 3.6.1.31); HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH)] - KLUYVEROMYCES LACTIS (YEAST). 
HIS2_NEUCR HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN [INCLUDES: PHOSPHORIBOSYL-AMP CYCLOHYDROLASE (EC 3.5.4.19); PHOSPHORIBOSYL-ATP PYROPHOSPHOHYDROLASE (EC 3.6.1.31); HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH)] - NEUROSPORA CRASSA.
HIS2_PICPA HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN [INCLUDES: PHOSPHORIBOSYL-AMP CYCLOHYDROLASE (EC 3.5.4.19); PHOSPHORIBOSYL-ATP PYROPHOSPHOHYDROLASE (EC 3.6.1.31); HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH)] - PICHIA PASTORIS (YEAST).
HIS2_SACBA HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN [INCLUDES: PHOSPHORIBOSYL-AMP CYCLOHYDROLASE (EC 3.5.4.19); PHOSPHORIBOSYL-ATP PYROPHOSPHOHYDROLASE (EC 3.6.1.31); HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH)] - SACCHAROMYCES BAYANUS (YEAST).
HIS2_YEAST HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN [INCLUDES: PHOSPHORIBOSYL-AMP CYCLOHYDROLASE (EC 3.5.4.19); PHOSPHORIBOSYL-ATP PYROPHOSPHOHYDROLASE (EC 3.6.1.31); HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH)] - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HISX_ARCFU HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - ARCHAEOGLOBUS FULGIDUS.
HISX_BACSU HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - BACILLUS SUBTILIS.
HISX_BRAOC HISTIDINOL DEHYDROGENASE, CHLOROPLAST PRECURSOR (EC 1.1.1.23) (HDH) - BRASSICA OLERACEA VAR. CAPITATA (CABBAGE).
HISX_ECOLI HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - ESCHERICHIA COLI.
HISX_HAEIN HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - HAEMOPHILUS INFLUENZAE.
HISX_LACLA HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - LACTOCOCCUS LACTIS (SUBSP. LACTIS) (STREPTOCOCCUS LACTIS).
HISX_METJA HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - METHANOCOCCUS JANNASCHII.
HISX_METTH HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - METHANOBACTERIUM THERMOAUTOTROPHICUM.
HISX_MYCSM HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - MYCOBACTERIUM SMEGMATIS.
HISX_MYCTU HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - MYCOBACTERIUM TUBERCULOSIS.
HISX_SALTY HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - SALMONELLA TYPHIMURIUM.
HISX_STRCO HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - STREPTOMYCES COELICOLOR.
HISX_SULSO HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - SULFOLOBUS SOLFATARICUS.
HISX_SYNY3 HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
O59626 HISTIDINOL DEHYDROGENASE - PYROCOCCUS FURIOSUS.
O66976 HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - AQUIFEX AEOLICUS.
O74712 HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN [INCLUDES: PHOSPHORIBOSYL-AMP CYCLOHYDROLASE (EC 3.5.4.19); PHOSPHORIBOSYL-ATP PYROPHOSPHOHYDROLASE (EC 3.6.1.31); HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH)] - CANDIDA ALBICANS (YEAST).

Q12201 DNA FOR PPIC9K EXPRESSION VECTOR - PICHIA PASTORIS (YEAST).

P72946 HISTIDINOL DEHYDROGENASE - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
Scan History
OWL25_1    2  100  NSINGLE    
SPTR37_9f 2 24 NSINGLE
Initial Motifs
Motif 1  width=25
Element Seqn Id St Int Rpt
VNPIIENVRDKGNSALLEYTEKFDG HIS2_YEAST 388 388 -
VNDILDNVKARGDEALREYSAKFDK HISX_ECOLI 36 36 -
VSDILDNVKTRGDDALREYSAKFDK HISX_SALTY 36 36 -
IVPIIEDVRKNGDKAVLSYTHKFEK HIS2_NEUCR 462 462 -
VNPIIDAVRSKGDTAVKEYTERFDK HISX_BRAOC 64 64 -

Motif 2 width=28
Element Seqn Id St Int Rpt
VETQPGVLCSRFPRPIEKVGLYIPGGTA HIS2_YEAST 462 49 -
VETQPGVRCQQVTRPVASVGLYIPGGSA HISX_ECOLI 109 48 -
VETQPGVRCQQVTRPVSSVGLYIPGGSA HISX_SALTY 109 48 -
VETMPGVVCSRFSRPIEAVGCYIPGGTA HIS2_NEUCR 536 49 -
VENMKGVRCKRVSRSIGSVGLYVPGGTA HISX_BRAOC 135 46 -

Motif 3 width=27
Element Seqn Id St Int Rpt
ILPSTALMLGVPAQVAQCKEIVFASPP HIS2_YEAST 490 0 -
PLFSTVLMLATPARIAGCKKVVLCSPP HISX_ECOLI 137 0 -
PLFSTVLMLATPARIAGCQKVVLCSPP HISX_SALTY 137 0 -
VLPSTALMLGVPAMVAGCNKIVFASPP HIS2_NEUCR 564 0 -
VLPSTALMLAIPAQIAGCKTVVLATPP HISX_BRAOC 163 0 -

Motif 4 width=27
Element Seqn Id St Int Rpt
EVVYVAEKVGASKIVLAGGAQAVAAMA HIS2_YEAST 526 9 -
EILYAAQLCGVQDVFNVGGAQAIAALA HISX_ECOLI 168 4 -
EILYAAQLCGVQEIFNVGGAQAIAALA HISX_SALTY 168 4 -
EIVYVAHKVGAESIVLAGGAQAVAAMV HIS2_NEUCR 599 8 -
EVLYCAKRAGVTHILKAGGAQAIAAMA HISX_BRAOC 198 8 -

Motif 5 width=26
Element Seqn Id St Int Rpt
ETIPKVDKILGPGNQFVTAAKMYVQN HIS2_YEAST 556 3 -
ESVPKVDKIFGPGNAFVTEAKRQVSQ HISX_ECOLI 198 3 -
ESVPKVDKIFGPGNAFVTEAKRQVSQ HISX_SALTY 198 3 -
ESITKVDKILGPGNQFVTAANMFVSN HIS2_NEUCR 628 2 -
DSCPKVEKIFGPGNQYVTAAKMILQN HISX_BRAOC 228 3 -

Motif 6 width=22
Element Seqn Id St Int Rpt
IDMPAGPSEVLVIADEDADVDF HIS2_YEAST 589 7 -
IDMPAGPSEVLVIADSGATPDF HISX_ECOLI 230 6 -
IDMPAGPSEVLVIADSGATPDF HISX_SALTY 230 6 -
IDMPAGPSEVLVIAHKDANPAF HIS2_NEUCR 661 7 -
IDMPAGPSEVLVIADEHASPVY HISX_BRAOC 260 6 -

Motif 7 width=20
Element Seqn Id St Int Rpt
VASDLLSQAEHGIDSQVILV HIS2_YEAST 611 0 -
VASDLLSQAEHGPDSQVILL HISX_ECOLI 252 0 -
VASDLLSQAEHGPDSQVILL HISX_SALTY 252 0 -
VASDLLSRAEHGVDSQVILI HIS2_NEUCR 683 0 -
IAADLLSQAEHGPDSQVVLV HISX_BRAOC 282 0 -

Motif 8 width=26
Element Seqn Id St Int Rpt
SNQYAPEHLILQIANANDYVKLVDNA HIS2_YEAST 681 50 -
SNQYGPEHLIIQTRNARELVDSITSA HISX_ECOLI 320 48 -
SNQYGPEHLIIQTRNARDLVDAITSA HISX_SALTY 320 48 -
SNKYAPEHLILQIKEAEKAVDLVMNA HIS2_NEUCR 753 50 -
SNLYAPEHLIINVKDAEKWEGLIENA HISX_BRAOC 351 49 -

Motif 9 width=19
Element Seqn Id St Int Rpt
YSSGTNHTLPTYGYARQYS HIS2_YEAST 722 15 -
YASGTNHVLPTYGYTATCS HISX_ECOLI 361 15 -
YASGTNHVLPTYGYTATCS HISX_SALTY 361 15 -
YSAGVNHSLPTYGFAKQYS HIS2_NEUCR 791 12 -
YASGTNHVLPTYGYARMYS HISX_BRAOC 392 15 -
Final Motifs
Motif 1  width=25
Element Seqn Id St Int Rpt
VNPIIENVRDRGDSALLEYTEKFDG HIS2_SACBA 388 388 -
VNPIIENVRDKGNSALLEYTEKFDG HIS2_YEAST 388 388 -
VNPIIENVIKNGDKALVELTAKFDG HIS2_KLULA 384 384 -
VKPIVDNVRQNGDKALLELTAKFDG HIS2_PICPA 440 440 -
VNDILDNVKARGDEALREYSAKFDK HISX_ECOLI 36 36 -
VSDILDNVKTRGDDALREYSAKFDK HISX_SALTY 36 36 -
VNAIRENVAYNGDRALFELCEKFDG HISX_HAEIN 33 33 -
VLPIIEKVKSDGDKALIELTSKFDG O74712 430 430 -
IVPIIEDVRKNGDKAVLSYTHKFEK HIS2_NEUCR 462 462 -
VNPIIDAVRSKGDTAVKEYTERFDK HISX_BRAOC 64 64 -
VADIISMVRDGGDDALRELTGRFDG HISX_METTH 31 31 -
VMEILKDVKEKGDEALKYYTKKFDG HISX_METJA 36 36 -
VQQIVADIQKNGDTALFNYAKKFDG HISX_LACLA 33 33 -
VKEILKRVREEGDRAVIEFTKKFDG O66976 35 35 -
VRSIIEDVKANGDQAVRSYTAKFDC HISX_BACSU 29 29 -
VRPIVDAVAQRGAQAALEYGESFDG HISX_MYCSM 42 42 -
VRPIVAAVAERGAEAALDFGASFDG HISX_MYCTU 35 35 -
VKPIVEAVKREGDKAVIRFTRDLDG HISX_ARCFU 20 20 -
VRPICEAVHHRGDAALIDFTEQFDG HISX_STRCO 36 36 -
VREILKDIRERGLEAIREYSKKFDG O59626 7 7 -
VKDIIESVKTKGDNALYELTEKLDK HISX_SULSO 21 21 -
AKEVIEQVKMEGDAGVLHYSRQFDF HISX_SYNY3 33 33 -

Motif 2 width=28
Element Seqn Id St Int Rpt
VETQPGVLCSRFPRPIEKVGLYIPGGTA HIS2_SACBA 462 49 -
VETQPGVLCSRFPRPIEKVGLYIPGGTA HIS2_YEAST 462 49 -
VETQPGVVCSRFPRPIEKVGLYIPGGTA HIS2_KLULA 458 49 -
VETCPGVVCSRFARPIEKVGLYIPGGTA HIS2_PICPA 512 47 -
VETQPGVRCQQVTRPVASVGLYIPGGSA HISX_ECOLI 109 48 -
VETQPGVRCQQVTRPVSSVGLYIPGGSA HISX_SALTY 109 48 -
LEIQEGVRCQVVTRPISCVGLYIPGGSA HISX_HAEIN 106 48 -
VETSPGVYCSRFAKPIENVGLYVPGGTA O74712 504 49 -
VETMPGVVCSRFSRPIEAVGCYIPGGTA HIS2_NEUCR 536 49 -
VENMKGVRCKRVSRSIGSVGLYVPGGTA HISX_BRAOC 135 46 -
SEVRPGVMAGQLVRPIDSVGCYIPGGRA HISX_METTH 104 48 -
NVENNGIILGQVVRAIEKVGCYVPGGRA HISX_METJA 110 49 -
IFKENGVIMGQIARPLERVALYVPGGTA HISX_LACLA 108 50 -
FKEEEGIILGQKVVPLEKVGVYVPGGKA O66976 109 49 -
YHRKDGTMLGQKVTALDSAGVYVPGGTA HISX_BACSU 102 48 -
TTLAPGATVTERWVPVERVGLYVPGGNA HISX_MYCSM 115 48 -
TTLGPGATVTERWVPVERVGLYVPGGNA HISX_MYCTU 108 48 -
KVEFEDCVMGKIYTPIEKVGAYIPGGRA HISX_ARCFU 93 48 -
TQVVPGGSVTEKWVPVERVGLYVPGGRS HISX_STRCO 109 48 -
LYIENGSLYGLIYKPLKRIRIYVPGGKP O59626 78 46 -
GGGYQGISFGVIWRSIEKIGIYVPSGKY HISX_SULSO 93 47 -
AEIEPGVFAGEKITPLPTVGLYVPRGKG HISX_SYNY3 109 51 -

Motif 3 width=27
Element Seqn Id St Int Rpt
ILPSTALMLGVPAQVAQCKEIVFASPP HIS2_SACBA 490 0 -
ILPSTALMLGVPAQVAQCKEIVFASPP HIS2_YEAST 490 0 -
ILPSTALMLGVPAQVAGCKEIVFASPP HIS2_KLULA 486 0 -
ILPSTSLMLGVPAKVAGCKEIVFASPP HIS2_PICPA 540 0 -
PLFSTVLMLATPARIAGCKKVVLCSPP HISX_ECOLI 137 0 -
PLFSTVLMLATPARIAGCQKVVLCSPP HISX_SALTY 137 0 -
PLFSTVLMLAIPAKIAGCKKIVLCSPP HISX_HAEIN 134 0 -
VLPSTAMMLGVPAKVAGCKNIIVASPP O74712 532 0 -
VLPSTALMLGVPAMVAGCNKIVFASPP HIS2_NEUCR 564 0 -
VLPSTALMLAIPAQIAGCKTVVLATPP HISX_BRAOC 163 0 -
VYPSTILMTVIPARIAGVERIVCCTPP HISX_METTH 132 0 -
FYPSTVLMTTIPAKVAGCEEIYITSPP HISX_METJA 138 0 -
AYPSTVIMNAVPALLAGVKEIIMITPV HISX_LACLA 136 0 -
AYPSTVLMNVVPASVAGVEEIIMVSPK O66976 137 0 -
AYPSSVLMNVIPALVAGVERIVLVTPP HISX_BACSU 130 0 -
VYPSSVVMNVVPAQTAGVDSMVIASPP HISX_MYCSM 143 0 -
VYPSSVVMNVVPAQAAGVDSLVVASPP HISX_MYCTU 136 0 -
SYPSTALMIGVPAKIAGVEKLVACTPP HISX_ARCFU 121 0 -
VYPSSVVMNVVPAQEAGVGSIALASPA HISX_STRCO 137 0 -
PLPSTLMMVGVPARVAGVKEIVVTNPP O59626 105 -1 -
SYPSTLLMAGIPAKVAKVKEIYVASPP HISX_SULSO 121 0 -
AFPSMMLMLAVPARVAGVKKIVVCTPP HISX_SYNY3 137 0 -

Motif 4 width=27
Element Seqn Id St Int Rpt
EVVYVAEKVGARMIVLAGGAQAVAAMA HIS2_SACBA 526 9 -
EVVYVAEKVGASKIVLAGGAQAVAAMA HIS2_YEAST 526 9 -
EVVYVASKVGASKIVLAGGAQAIAAMA HIS2_KLULA 522 9 -
EVIYVAHKVGAKCIVLAGGAQAVAAMA HIS2_PICPA 575 8 -
EILYAAQLCGVQDVFNVGGAQAIAALA HISX_ECOLI 168 4 -
EILYAAQLCGVQEIFNVGGAQAIAALA HISX_SALTY 168 4 -
EILYTAHLCGVETIYAIGGAQAVFAMA HISX_HAEIN 165 4 -
EVVYVAHKLGAKCIVMAGGAQAVTAMA O74712 568 9 -
EIVYVAHKVGAESIVLAGGAQAVAAMV HIS2_NEUCR 599 8 -
EVLYCAKRAGVTHILKAGGAQAIAAMA HISX_BRAOC 198 8 -
AVLVAADMAGASEIYRVGGAQAVAAMA HISX_METTH 167 8 -
ATLIAGDIVGVSAIYKVGGVQAIGALA HISX_METJA 173 8 -
NILAAAEVCGIETIYKVGGAQGVAAVA HISX_LACLA 171 8 -
YTLAAAYIAGVSRVFQVGGAQAIGALA O66976 167 3 -
GVLVAAAELGIKDIYKMGGAQAIAALA HISX_BACSU 165 8 -
TILAAAALLGVDEVWAVGGAQAVALLA HISX_MYCSM 180 10 -
TILAAARLLGVDEVWAVGGAQAVALLA HISX_MYCTU 173 10 -
LTLVALDIAEFDEVYKAGGAQAIAAMA HISX_ARCFU 156 8 -
TILAACALLGVDEVYAAGGATAVAMFA HISX_STRCO 174 10 -
YILYIAKLLKIEEVYKLGGIQAIAAMA O59626 139 7 -
ALAYVAIKLGVNEVYKIGGAQAIAALA HISX_SULSO 156 8 -
VSLVTARMAGVDEVYKLGGVQALAAIA HISX_SYNY3 172 8 -

Motif 5 width=26
Element Seqn Id St Int Rpt
ETIPKVDKVLGPGNQFVTAAKMYVQN HIS2_SACBA 556 3 -
ETIPKVDKILGPGNQFVTAAKMYVQN HIS2_YEAST 556 3 -
ESVPKVDKILGPGNQFVTAAKMYVQN HIS2_KLULA 552 3 -
ETVPKCDKIFGPGNQFVTAAKMMVQN HIS2_PICPA 605 3 -
ESVPKVDKIFGPGNAFVTEAKRQVSQ HISX_ECOLI 198 3 -
ESVPKVDKIFGPGNAFVTEAKRQVSQ HISX_SALTY 198 3 -
ESVAKVDKIFGPGNAFVTEAKRQVAQ HISX_HAEIN 195 3 -
ESVLKCDKILGPGNQFVTAAKMYVQN O74712 598 3 -
ESITKVDKILGPGNQFVTAANMFVSN HIS2_NEUCR 628 2 -
DSCPKVEKIFGPGNQYVTAAKMILQN HISX_BRAOC 228 3 -
ETIRPVDKIVGPGNIFVTAAKKLVYG HISX_METTH 197 3 -
ETIPKVDIIVGPGNIYVTTAKKMVYG HISX_METJA 203 3 -
ESIPKVDKIVGPGNIFVATAKKICYG HISX_LACLA 201 3 -
EKIPKVDKIVGPGNIYVALAKKLVFG O66976 197 3 -
ETIEPVDKITGPGNIYVALAKREVFG HISX_BACSU 195 3 -
AELAPVDMITGPGNIYVTAAKRICRS HISX_MYCSM 215 8 -
AALTPVDMITGPGNIYVTAAKRLCRS HISX_MYCTU 208 8 -
ETVEKVYKIVGPGNIYVTAAKLLVAK HISX_ARCFU 186 3 -
ESCPPANMVTGPGNIWVAAAKRFFTG HISX_STRCO 204 3 -
IGMKKVQKIFGPGNKFVNEAKRQVFG O59626 168 2 -
ESVKKVYKIVGPGNVYVQAAKYLVSS HISX_SULSO 186 3 -
KTVSKVDKLIGPCSIYGAAAKRLLSG HISX_SYNY3 202 3 -

Motif 6 width=22
Element Seqn Id St Int Rpt
IDMPAGPSEVLVIADEDADADF HIS2_SACBA 589 7 -
IDMPAGPSEVLVIADEDADVDF HIS2_YEAST 589 7 -
IDMPAGPSEVLVICDEEADVDF HIS2_KLULA 585 7 -
IDMPAGPSEVLVIADKYADPDF HIS2_PICPA 638 7 -
IDMPAGPSEVLVIADSGATPDF HISX_ECOLI 230 6 -
IDMPAGPSEVLVIADSGATPDF HISX_SALTY 230 6 -
IDMPAGPSEVLVIADESADPEF HISX_HAEIN 225 4 -
IDMPAGPSEVLVIADSNADADF O74712 631 7 -
IDMPAGPSEVLVIAHKDANPAF HIS2_NEUCR 661 7 -
IDMPAGPSEVLVIADEHASPVY HISX_BRAOC 260 6 -
IDFPAGPSEVLIIADETASPEY HISX_METTH 226 3 -
IDFLAGPSEVLIIADETANAEF HISX_METJA 232 3 -
IDMIAGPSEVLVIADKTAKPKY HISX_LACLA 230 3 -
IDMIAGPSEVLVIADERANPTW O66976 226 3 -
IDMIAGPSEIVVLADETAIPSE HISX_BACSU 224 3 -
IDAEAGPTEIAILADHTADPVH HISX_MYCSM 244 3 -
IDAEAGPTEIAILADHTADPVH HISX_MYCTU 237 3 -
IDMPAGPSEILVIADETANADF HISX_ARCFU 215 3 -
IDAEAGPTEIAVLADSTADPVH HISX_STRCO 233 3 -
IDSLAGPSEIAVIADESADKDF O59626 197 3 -
IDGIEGPTELVIIADETAKAEY HISX_SULSO 215 3 -
VGLPAGPSESIVLADETTDPKL HISX_SYNY3 231 3 -

Motif 7 width=20
Element Seqn Id St Int Rpt
VASDLLSQAEHGIDSQVILV HIS2_SACBA 611 0 -
VASDLLSQAEHGIDSQVILV HIS2_YEAST 611 0 -
VASDLLSQAEHGIDSQVILV HIS2_KLULA 607 0 -
VVSDLLSQAEHGIDSQVILL HIS2_PICPA 660 0 -
VASDLLSQAEHGPDSQVILL HISX_ECOLI 252 0 -
VASDLLSQAEHGPDSQVILL HISX_SALTY 252 0 -
VASDLLSQAEHGADSQVILV HISX_HAEIN 247 0 -
VASDLLSQAEHGVDSQVILI O74712 653 0 -
VASDLLSRAEHGVDSQVILI HIS2_NEUCR 683 0 -
IAADLLSQAEHGPDSQVVLV HISX_BRAOC 282 0 -
IALEILAQAEHDPQAASVLV HISX_METTH 248 0 -
VALDFIAQAEHDPNASCVIT HISX_METJA 254 0 -
IAADLMAQAEHDKLASAILV HISX_LACLA 252 0 -
VAADMLSQAEHDELAASILL O66976 248 0 -
IAADLLSQAEHDKLSSCVFV HISX_BACSU 246 0 -
VAADLISQAEHDEMAASVLV HISX_MYCSM 266 0 -
VAADLISQAEHDELAASVLV HISX_MYCTU 259 0 -
IACDCLAQLEHDPMAVAVVL HISX_ARCFU 237 0 -
VASDLISLAEHDPLAAAVLV HISX_STRCO 255 0 -
VLYDLLSQLEHGKDSKAWLL O59626 219 0 -
VALDMKAQAEHGPDTYIVLL HISX_SULSO 237 0 -
AALDLLIEAEHGSDSAALLV HISX_SYNY3 253 0 -

Motif 8 width=26
Element Seqn Id St Int Rpt
SNKYAPEHLILQIANANDYVKLVDNA HIS2_SACBA 681 50 -
SNQYAPEHLILQIANANDYVKLVDNA HIS2_YEAST 681 50 -
SNQYAPEHLILQISNAEDYVKDVDHA HIS2_KLULA 677 50 -
SNQYAPEHLILQIENASYVDQVQHAG HIS2_PICPA 730 50 -
SNQYGPEHLIIQTRNARELVDSITSA HISX_ECOLI 320 48 -
SNQYGPEHLIIQTRNARDLVDAITSA HISX_SALTY 320 48 -
SNEYAPEHLIVQTKNARKLLPYLDNA HISX_HAEIN 315 48 -
SNQYAPEHLILQIDDAPSYVPDSIEN O74712 723 50 -
SNKYAPEHLILQIKEAEKAVDLVMNA HIS2_NEUCR 753 50 -
SNLYAPEHLIINVKDAEKWEGLIENA HISX_BRAOC 351 49 -
SNAYAPEHLVIMTDSPEETLEGIRNA HISX_METTH 317 49 -
SNKYAPEHLEILTKNPEEVLNKIKHA HISX_METJA 321 47 -
SNQLAPEHLEVLTSEPLTQLPKIKNA HISX_LACLA 321 49 -
ANYIAPEHLEVMVREPMALLPELKHA O66976 317 49 -
VNTLAPEHLEIITQSPEALLGSIKHA HISX_BACSU 315 49 -
VNAYAAEHLEIQTVDAPGVAGRIRSA HISX_MYCSM 336 50 -
VNAYAAEHLEIQTADAPQVASRIRSA HISX_MYCTU 329 50 -
SNEFAPEHLTVAVKNPEEWLGKVRNA HISX_ARCFU 294 37 -
VDAYGAEHLEIQTADAAAVADRVKNA HISX_STRCO 326 51 -
ANEIAPEHLEIITREPLKLVDLIENA O59626 268 29 -
ANKIAPEHLSLYVKDAYTLMDKIVNA HISX_SULSO 292 35 -
INDYAPEHLQVLTADPLKLVGKIDNA HISX_SYNY3 324 51 -

Motif 9 width=19
Element Seqn Id St Int Rpt
YSSGTNHTLPTYGYARQYS HIS2_SACBA 722 15 -
YSSGTNHTLPTYGYARQYS HIS2_YEAST 722 15 -
YSSGTNHTLPTYGYARQYS HIS2_KLULA 718 15 -
YSSGTNHTLPTYGYARQYS HIS2_PICPA 770 14 -
YASGTNHVLPTYGYTATCS HISX_ECOLI 361 15 -
YASGTNHVLPTYGYTATCS HISX_SALTY 361 15 -
YASGTNHVLPTYGYTKTYS HISX_HAEIN 356 15 -
YSSGTNHTLPTYGYARQYS O74712 765 16 -
YSAGVNHSLPTYGFAKQYS HIS2_NEUCR 791 12 -
YASGTNHVLPTYGYARMYS HISX_BRAOC 392 15 -
YGSGTNHVLPTSGCARMYS HISX_METTH 358 15 -
YASGTNHVLPTSQFARMSS HISX_METJA 362 15 -
YMSGSNHVLPTGGTAKFYS HISX_LACLA 362 15 -
YVLGPNHTLPTGGSTRFFS O66976 358 15 -
YFAGPNHVLPTNGTARFSS HISX_BACSU 356 15 -
YCAGSNHVLPTAGCARHSS HISX_MYCSM 377 15 -
YCAGSNHVLPTAGCARHSS HISX_MYCTU 370 15 -
YASGTNHVLPTAGYAKIYG HISX_ARCFU 335 15 -
YAAGSNHVLPTGGCACHSS HISX_STRCO 367 15 -
YFLGVNHVLPTGGAAKFMG O59626 309 15 -
YVAGPNHILPTNGWAKIRG HISX_SULSO 332 14 -
YAIGVNAVLPTGGFARSYS HISX_SYNY3 365 15 -