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PR00082

Identifier
GLFDHDRGNASE  [View Relations]  [View Alignment]  
Accession
PR00082
No. of Motifs
4
Creation Date
03-SEP-1993  (UPDATE 07-JUN-1999)
Title
Glutamate/leucine/phenylalanine/valine dehydrogenase signature
Database References

PROSITE; PS00074 GLFV_DEHYDROGENASE
PFAM; PF00208 GLFV_dehydrog
INTERPRO; IPR001625
Literature References
1. MAVROTHALASSITIS, G., TZIMAGIORGIS, G., MITSIALIS, A., ZANNIS, V.,
PLAITAKIS, A., PAPAMATHEAKIS, J. AND MOSCHONAS, N.
Isolation and characterization of cDNA clones encoding human liver
glutamate dehydrogenase - Evidence for a small gene family.
PROC.NATL.ACAD.SCI.U.S.A. 85(10) 3494-3498 (1988).
 
2. MOYE, W.S., AMURO, N., RAO, J.K.M. AND ZALKIN, H.
Nucleotide sequence of yeast GDH1 encoding nicotinamide adenine dinucleotide
phosphate-dependent glutamate dehydrogenase.
J.BIOL.CHEM. 260(14) 8502-8508 (1985).
 
3. OKAZAKI, N., HIBINO, Y., ASANO, Y., OHMORI, M., NUMAO, N. AND KONDO, K.
Cloning and nucleotide sequencing of phenylalanine dehydrogenase gene of
Bacillus sphaericus.
GENE 63(2) 337-341 (1988).

Documentation
Glutamate, leucine and phenylalanine dehydrogenases are structurally
and functionally related. They contain a Gly-rich region containing a
conserved Lys residue, which has been implicated in the catalytic activity,
in each case a reversible oxidative deamination reaction. Glutamate 
dehydrogenase catalyses the reversible oxidative deamination of L-glutamate
to alpha-ketoglutarate, using NAD and/or NADP as cofactors [1]. Two separate
enzymes are present in yeasts: the NADP-dependent enzyme, which catalyses
the amination of alpha-ketoglutarate to L-glutamate; and the NAD-dependent
enzyme, which catalyses the reverse reaction [2] - this form links the
L-amino acids with the Krebs cycle, which provides a major pathway for
metabolic interconversion of alpha-amino acids and alpha-keto acids [1].
 
Leucine dehydrogenase is an NAD-dependent enzyme that catalyses the 
reversible deamination of leucine and several other aliphatic amino acids to
their keto analogues. Phenylalanine dehydrogenase is also NAD-dependent and
catalyses the reversible oxidative deamination of L-phenylalanine to form
phenyl-pyruvate [3].
 
GLFDHDRGNASE is a 4-element fingerprint that provides a signature for
glutamate, leucine and phenylalanine dehydrogenases. The fingerprint was
derived from an initial alignment of 6 sequences: motif 1 includes part of
the region encoded by PROSITE pattern GLF_DEHYDROGENASE (PS00074), which
contains the conserved Gly-rich region presumed important in the catalytic
mechanism. Two iterations on OWL21.1 were required to reach convergence,
at which point a true set comprising 29 sequences was identified. Two
partial matches were also found, both of which are fragments.
 
An update on SPTR37_9f identified a true set of 70 sequences, and 2
partial matches.
Summary Information
  70 codes involving  4 elements
1 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
470707070
31110
21010
1234
True Positives
DHE2_CLODI    DHE2_CLOSY    DHE2_PEPAS    DHE2_PORGI    
DHE3_BOVIN DHE3_CHICK DHE3_DROME DHE3_HUMAN
DHE3_MOUSE DHE3_PYREN DHE3_PYRFU DHE3_PYRHO
DHE3_PYRKO DHE3_RAT DHE3_RHISN DHE3_SULSO
DHE3_THELI DHE3_THEMA DHE3_VITVI DHE4_AGABI
DHE4_BACFR DHE4_BACTN DHE4_CORGL DHE4_DEBOC
DHE4_ECOLI DHE4_EMENI DHE4_GIALA DHE4_HAEIN
DHE4_HALSA DHE4_HELPY DHE4_HUMAN DHE4_LACBI
DHE4_NEUCR DHE4_PRERU DHE4_SALTY DHE4_SYNY3
DHE4_UNKP DHE4_YEAST DHE5_YEAST DHLE_BACST
DHLE_BACSU DHPH_BACSH DHPH_THEIN O02375
O04871 O04872 O04937 O24119
O60995 O60996 O61083 O69056
O74024 O87403 P91624 P93541
P97014 Q23621 Q38946 Q43260
Q43314 Q53560 Q53872 Q59194
Q59224 Q60030 VDH_STRCO VDH_STRFR
YPCA_BACSU YWEB_BACSU
True Positive Partials
Codes involving 3 elements
Q59771
Codes involving 2 elements
O85768
Sequence Titles
DHE2_CLODI  NAD-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.2) (NAD-GDH) - CLOSTRIDIUM DIFFICILE. 
DHE2_CLOSY NAD-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.2) (NAD-GDH) - CLOSTRIDIUM SYMBIOSUM (BACTEROIDES SYMBIOSUS).
DHE2_PEPAS NAD-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.2) (NAD-GDH) - PEPTOSTREPTOCOCCUS ASACCHAROLYTICUS (PEPTOCOCCUS ASACCHAROLYTICUS).
DHE2_PORGI NAD-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.2) (NAD-GDH) (SURFACE-ASSOCIATED PROTEIN PGAG1) - PORPHYROMONAS GINGIVALIS (BACTEROIDES GINGIVALIS).
DHE3_BOVIN GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - BOS TAURUS (BOVINE).
DHE3_CHICK GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - GALLUS GALLUS (CHICKEN).
DHE3_DROME GLUTAMATE DEHYDROGENASE PRECURSOR (EC 1.4.1.3) (GDH) - DROSOPHILA MELANOGASTER (FRUIT FLY).
DHE3_HUMAN GLUTAMATE DEHYDROGENASE 1 PRECURSOR (EC 1.4.1.3) (GDH) - HOMO SAPIENS (HUMAN).
DHE3_MOUSE GLUTAMATE DEHYDROGENASE PRECURSOR (EC 1.4.1.3) (GDH) - MUS MUSCULUS (MOUSE).
DHE3_PYREN GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - PYROCOCCUS ENDEAVORI.
DHE3_PYRFU GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - PYROCOCCUS FURIOSUS.
DHE3_PYRHO GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - PYROCOCCUS HORIKOSHII.
DHE3_PYRKO GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - PYROCOCCUS KODAKARAENSIS.
DHE3_RAT GLUTAMATE DEHYDROGENASE PRECURSOR (EC 1.4.1.3) (GDH) - RATTUS NORVEGICUS (RAT).
DHE3_RHISN PROBABLE GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - RHIZOBIUM SP. (STRAIN NGR234).
DHE3_SULSO GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - SULFOLOBUS SOLFATARICUS.
DHE3_THELI GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - THERMOCOCCUS LITORALIS.
DHE3_THEMA GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - THERMOTOGA MARITIMA.
DHE3_VITVI GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - VITIS VINIFERA (GRAPE).
DHE4_AGABI NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) - AGARICUS BISPORUS (COMMON MUSHROOM).
DHE4_BACFR NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) (NAD(P)H-DEPENDENT GLUTAMATE DEHYDROGENASE) - BACTEROIDES FRAGILIS.
DHE4_BACTN NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) (NAD(P)H-DEPENDENT GLUTAMATE DEHYDROGENASE) - BACTEROIDES THETAIOTAOMICRON.
DHE4_CORGL NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) - CORYNEBACTERIUM GLUTAMICUM (BREVIBACTERIUM FLAVUM).
DHE4_DEBOC NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) - DEBARYOMYCES OCCIDENTALIS (YEAST) (SCHWANNIOMYCES OCCIDENTALIS).
DHE4_ECOLI NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) - ESCHERICHIA COLI.
DHE4_EMENI NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS).
DHE4_GIALA NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) - GIARDIA LAMBLIA (GIARDIA INTESTINALIS).
DHE4_HAEIN NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) - HAEMOPHILUS INFLUENZAE.
DHE4_HALSA NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) - HALOBACTERIUM SALINARIUM.
DHE4_HELPY NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
DHE4_HUMAN GLUTAMATE DEHYDROGENASE 2 PRECURSOR (EC 1.4.1.3) (GDH) - HOMO SAPIENS (HUMAN).
DHE4_LACBI NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) - LACCARIA BICOLOR.
DHE4_NEUCR NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) - NEUROSPORA CRASSA.
DHE4_PRERU NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) (NAD(P)H-DEPENDENT GLUTAMATE DEHYDROGENASE) - PREVOTELLA RUMINICOLA (BACTEROIDES RUMINICOLA).
DHE4_SALTY NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) - SALMONELLA TYPHIMURIUM.
DHE4_SYNY3 NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
DHE4_UNKP NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (NADP-GDH) - UNKNOWN PROKARYOTIC ORGANISM.
DHE4_YEAST NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1 (EC 1.4.1.4) (NADP-GDH 1) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
DHE5_YEAST NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 2 (EC 1.4.1.4) (NADP-GDH 2) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
DHLE_BACST LEUCINE DEHYDROGENASE (EC 1.4.1.9) (LEUDH) - BACILLUS STEAROTHERMOPHILUS.
DHLE_BACSU LEUCINE DEHYDROGENASE (EC 1.4.1.9) (LEUDH) - BACILLUS SUBTILIS.
DHPH_BACSH PHENYLALANINE DEHYDROGENASE (EC 1.4.1.20) (PHEDH) - BACILLUS SPHAERICUS.
DHPH_THEIN PHENYLALANINE DEHYDROGENASE (EC 1.4.1.20) (PHEDH) - THERMOACTINOMYCES INTERMEDIUS.
O02375 PUTATIVE GLUTAMATE DEHYDROGENASE - HAEMONCHUS CONTORTUS.
O04871 GLUTAMATE DEHYDROGENASE MUTANT (EC 1.4.1.2) (GLUTAMIC DEHYDROGENASE) - ZEA MAYS (MAIZE).
O04872 GLUTAMATE DEHYDROGENASE (EC 1.4.1.2) (GLUTAMIC DEHYDROGENASE) - ZEA MAYS (MAIZE).
O04937 NADH GLUTAMATE DEHYDROGENASE (EC 1.4.1.2) (GLUTAMIC DEHYDROGENASE) - NICOTIANA PLUMBAGINIFOLIA (LEADWORT-LEAVED TOBACCO).
O24119 NADH GLUTAMATE DEHYDROGENASE (EC 1.4.1.2) - NICOTIANA PLUMBAGINIFOLIA (LEADWORT-LEAVED TOBACCO).
O60995 GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) - TRYPANOSOMA CRUZI.
O60996 GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) - TRYPANOSOMA CRUZI.
O61083 PUTATIVE GLUTAMATE DEHYDROGENASE - TRYPANOSOMA CRUZI.
O69056 VALINE DEHYDROGENASE - STREPTOMYCES ALBUS.
O74024 GLUTAMATE DEHYDROGENASE - THERMOCOCCUS PROFUNDUS.
O87403 NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4) (GLUTAMATE DEHYDROGENASE (NADP+)) (GLUTAMIC DEHYDROGENASE) - BACILLUS LICHENIFORMIS.
P91624 GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GLUTAMATE DEHYDROGENASE (NAD(P)+)) (GLUTAMIC DEHYDROGENASE) - DROSOPHILA MELANOGASTER (FRUIT FLY).
P93541 GLUTAMATE DEHYDROGENASE (EC 1.4.1.2) (GLUTAMIC DEHYDROGENASE) - LYCOPERSICON ESCULENTUM (TOMATO).
P97014 PHENYLALANINE DEHYDROGENASE - SPOROSARCINA UREAE.
Q23621 ZK829.4 PROTEIN - CAENORHABDITIS ELEGANS.
Q38946 GLUTAMATE DEHYDROGENASE 2 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
Q43260 GLUTAMATE DEHYDROGENASE (EC 1.4.1.2) - ZEA MAYS (MAIZE).
Q43314 GLUTAMATE DEHYDROGENASE 1 (EC 1.4.4.2) (GLYCINE DEHYDROGENASE (DECARBOXYLATING)) (GLYCINE DECARBOXYLASE) (GLYCINE CLEAVAGE SYSTEM P-PROTEIN) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
Q53560 LEUCINE DEHYDROGENASE - BACILLUS LICHENIFORMIS.
Q53872 VALINE DEHYDROGENASE - STREPTOMYCES CINNAMONENSIS.
Q59194 LEUCINE DEHYDROGENASE LEUDH (EC 1.4.1.9) - BACILLUS CEREUS.
Q59224 PHENYLALANINE DEHYDROGENASE (EC 1.4.1.20) - BACILLUS BADIUS.
Q60030 LEUCINE DEHYDROGENASE (EC 1.4.1.9) - THERMOACTINOMYCES INTERMEDIUS.
VDH_STRCO VALINE DEHYDROGENASE (EC 1.4.1.-) (VALDH) - STREPTOMYCES COELICOLOR.
VDH_STRFR VALINE DEHYDROGENASE (EC 1.4.1.-) (VALDH) - STREPTOMYCES FRADIAE.
YPCA_BACSU HYPOTHETICAL 46.7 KD OXIDOREDUCTASE IN RECQ-CMK INTERGENIC REGION (EC 1.4.1.-) - BACILLUS SUBTILIS.
YWEB_BACSU HYPOTHETICAL 46.6 KD OXIDOREDUCTASE IN UNG-ROCA INTERGENIC REGION (EC 1.4.1.-) - BACILLUS SUBTILIS.

Q59771 L-PHENYLALANINE DEHYDROGENASE (EC 1.4.1.20) - RHODOCOCCUS SP.

O85768 HYPOTHETICAL 38.2 KD PROTEIN - LEGIONELLA PNEUMOPHILA.
Scan History
OWL21_1    2  100  NSINGLE    
OWL25_2 1 100 NSINGLE
SPTR37_9f 2 143 NSINGLE
Initial Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
IFKNALTGLNMGGGK DHE4_EMENI 100 100 -
TFKNALTTLPMGGGK DHE4_ECOLI 114 114 -
TFKNALTTLPMGGGK DHE4_SALTY 114 114 -
ILKNSLTTLPMGGGK DHE4_GIALA 111 111 -
TYKNAAAGLNLGGGK DHLE_BACST 66 66 -
TYKCSLADVDFGGGK DHPH_THEIN 67 67 -

Motif 2 width=23
Element Seqn Id St Int Rpt
VLTGKGGSWGGSLIRPEATGYGV DHE4_EMENI 179 64 -
VFTGKGLSFGGSLIRPEATGYGL DHE4_ECOLI 193 64 -
VFTGKGLSFGGSLIRPEATGYGL DHE4_SALTY 193 64 -
VLTGKNVKWGGSFIRPEATGYGA DHE4_GIALA 190 64 -
YVTGISPEFGSSGNPSPATAYGV DHLE_BACST 132 51 -
SFAGLPKSYGGKGDTSIPTALGV DHPH_THEIN 133 51 -

Motif 3 width=21
Element Seqn Id St Int Rpt
VAISGSGNVAQYAALKVIELG DHE4_EMENI 224 22 -
VSVSGSGNVAQYAIEKAMEFG DHE4_ECOLI 235 19 -
VAVSGSGNVAQYAIEKAMAFG DHE4_SALTY 235 19 -
VLLSGSGNVAQFACEKLIQLG DHE4_GIALA 232 19 -
VAVQGVGNVAYHLCRHLHEEG DHLE_BACST 176 21 -
VAIQGVGKVGERLLQLLVEVG DHPH_THEIN 177 21 -

Motif 4 width=12
Element Seqn Id St Int Rpt
ANAGGVAVSGLE DHE4_EMENI 377 132 -
ANAGGVATSGLE DHE4_ECOLI 372 116 -
ANAGGVATSGLE DHE4_SALTY 372 116 -
SNAGGVSVSGLE DHE4_GIALA 373 120 -
INAGGVINVADE DHLE_BACST 286 89 -
VNAGGLIQVADE DHPH_THEIN 289 91 -
Final Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
TWKTAVADIPYGGAK Q38946 88 88 -
TWKTAVADIPYGGAK O04937 88 88 -
TWKTAVVDIPYGGAK DHE3_VITVI 88 88 -
IFKNALTGLNMGGGK DHE4_EMENI 100 100 -
TWKTAVMNLPFGGGK DHE3_THEMA 91 91 -
TFKNALTTLPMGGGK DHE4_ECOLI 114 114 -
TFKNALTTLPMGGGK DHE4_SALTY 114 114 -
TWKTAVAKIPYGGAK Q43314 88 88 -
TWKTAVANIPYGGAK O04872 88 88 -
TWKTAVANIPYGGAK Q43260 88 88 -
TWKTAVANIPYGGAK P93541 88 88 -
TYKCAVVDVPFGGAK DHE3_HUMAN 169 169 -
TYKCAVVDVPFGGAK DHE4_HUMAN 169 169 -
TYKCAVVDVPFGGAK DHE3_RAT 169 169 -
TYKCAVVDVPFGGAK DHE3_MOUSE 169 169 -
TFKNALTTLPMGGGK DHE4_BACFR 110 110 -
IFKNALTGLSMGGGK DHE4_NEUCR 99 99 -
TWKTAVANIPYGGAK O04871 88 88 -
TWKTRVANIPYGGAK O24119 88 88 -
TFKNSLTTLPMGGGK DHE4_BACTN 110 110 -
TFKCSVTGIPYGGGK DHE2_CLODI 93 93 -
TWKTAVMDLPYGGGK DHE3_PYRFU 91 91 -
TWKTAVMDLPYGGGK DHE3_PYREN 91 91 -
TWKTAVMDLPYGGGK DHE3_PYRHO 91 91 -
TFKNALTGLSMGGGK DHE4_LACBI 97 97 -
IFKNALTGLDMGGGK DHE5_YEAST 97 97 -
TFKCALLNLPFGGAK DHE4_SYNY3 90 90 -
TFKNSLTTLPMGGGK O61083 114 114 -
IFKNALTTLPMGGAK DHE4_HAEIN 114 114 -
TFKNSLTTLPMGGAK DHE4_PRERU 110 110 -
TWKCAVMDLPFGGAK DHE4_HALSA 112 112 -
TWKVAVVDLPYGGGK O74024 91 91 -
TFKCACVDVPFGGAK DHE3_DROME 160 160 -
TFKCACVDVPFGGAK P91624 160 160 -
IFKNSLTGLDMGGGK DHE4_YEAST 96 96 -
TYKCAVVDVPFGGAK Q23621 147 147 -
TFKNALTGLSMGGGK DHE4_AGABI 97 97 -
AFKDSLTTLPMGGAK DHE2_CLOSY 111 111 -
IFKNSLTGQPIGGGK O87403 126 126 -
TFKNALTTLPMGGGK DHE4_UNKP 114 114 -
IFKNALTGLSMGGGK DHE4_DEBOC 102 102 -
TWKTAVMDLPYGGGK DHE3_THELI 91 91 -
TLKCSLVDVPFGGSK DHE3_RHISN 72 72 -
TFKNSLTTLPMGGGK O60995 114 114 -
TYKCAVVDVPFGGAK DHE3_BOVIN 112 112 -
TWKNSLLLLPYGGGK DHE3_SULSO 94 94 -
ILKNSLTTLPMGGGK DHE4_GIALA 111 111 -
TFKNSLTTLPMGGGK O60996 114 114 -
TYKCAVVDVPFGGAK DHE3_CHICK 115 115 -
MFKNALTTLPMGGGK DHE2_PORGI 110 110 -
IFKNSLTGLPIGGGK DHE4_CORGL 114 114 -
SLKCGIIDLPYGGGK YPCA_BACSU 104 104 -
TFKGGALGLPYGGGK DHE2_PEPAS 92 92 -
TLKCGIANLPYGGGK YWEB_BACSU 102 102 -
VLKNSLTTLAMGGAK DHE4_HELPY 110 110 -
TWKVAVVDLPYGGGK DHE3_PYRKO 90 90 -
TYKCAAVDVPFGGAK O02375 148 148 -
TYKNAAAGLNLGGGK DHLE_BACST 66 66 -
TYKNAAAGLNLGGGK Q53560 66 66 -
TYKNAAAGLNLGGGK DHLE_BACSU 66 66 -
TYKNAAAGLNLGGAK Q59194 68 68 -
TYKNAAAGLNLGGGK Q60030 66 66 -
SYKNALAGLPHGGGK VDH_STRFR 80 80 -
SYKNAMAGLDHGGGK Q53872 74 74 -
SYKNAMAGLDHGGGK VDH_STRCO 76 76 -
SYKNAMAGLEHGGGK O69056 77 77 -
TYKCAAADIDFGGGK DHPH_BACSH 77 77 -
TYKCSLADVDFGGGK DHPH_THEIN 67 67 -
TYKCAASDVDFGGGK Q59224 76 76 -
TYKCAAADVDFGGGK P97014 78 78 -

Motif 2 width=23
Element Seqn Id St Int Rpt
VVTGKPIDLGGSLGREAATGRGV Q38946 167 64 -
IVTGKPIDLGGSLGREAATGRGV O04937 167 64 -
VVTGKPIALGGSLGREAATGRGV DHE3_VITVI 167 64 -
VLTGKGGSWGGSLIRPEATGYGV DHE4_EMENI 179 64 -
IVTGKPVELGGSKGREEATGRGV DHE3_THEMA 171 65 -
VFTGKGLSFGGSLIRPEATGYGL DHE4_ECOLI 193 64 -
VFTGKGLSFGGSLIRPEATGYGL DHE4_SALTY 193 64 -
VVTGKPIDLGGSLGRDAATGRGV Q43314 167 64 -
VVTGKPVDLGGSLGRDAATGRGV O04872 167 64 -
VVTGKPVDLGGSLGRDAATGRGV Q43260 167 64 -
VVTGKPVDLGGSLGRDAATGRGA P93541 167 64 -
CVTGKPISQGGIHGRISATGRGV DHE3_HUMAN 254 70 -
CVTGKPISQGGIHGRISATGRGV DHE4_HUMAN 254 70 -
CVTGKPISQGGIHGRISATGRGV DHE3_RAT 254 70 -
CVTGKPISQGGIHGRISATGRGV DHE3_MOUSE 254 70 -
TFTGKGLEFGGSLIRPEATGFGG DHE4_BACFR 189 64 -
VLTGKGLSWGGSLIRPEATGYGL DHE4_NEUCR 178 64 -
VVTGKPVDLGGSLGRDAATGRRV O04871 167 64 -
VVTGKPIDLGGSLGRDAATGRGV O24119 167 64 -
TFTGKGREFGGSLIRPEATGYGN DHE4_BACTN 189 64 -
VITGKPVEFGGSLGRTAATGFGV DHE2_CLODI 173 65 -
IITGKPLSIGGSLGRIEATARGA DHE3_PYRFU 173 67 -
IITGKPLSIGGSLGRNEATARGA DHE3_PYREN 173 67 -
IITGKPLSIGGSLGRNEATARGA DHE3_PYRHO 173 67 -
MLTGKGLAWGGSFIRPEATGYGL DHE4_LACBI 176 64 -
VLTGKGLNWGGSLIRPEATGFGL DHE5_YEAST 176 64 -
VVTGKPVTMGGSQGRNTATGTGA DHE4_SYNY3 170 65 -
RFTGKGISFQGSQMRPEATGYGV O61083 193 64 -
VFTGRGLSFGGSLIRPEATGYGL DHE4_HAEIN 193 64 -
ILTGKGLEFGGSLIRPEATGYGN DHE4_PRERU 189 64 -
VVTGKPPVVGGSEGREEAPGRSV DHE4_HALSA 192 65 -
VITGKPLSIGGSLGRGTATAQGA O74024 173 67 -
CVTGKPINQGGIHGRVSATGRGV DHE3_DROME 245 70 -
CVTGKPINQGGIHGRVSATGRGV P91624 245 70 -
VLTGKGLNWGGSLIRPEATGYGL DHE4_YEAST 175 64 -
CITGKPIVSGGIHGRVSATGRGV Q23621 232 70 -
MLTGKGINWGGSFIRPEATGYGL DHE4_AGABI 176 64 -
VLTGKARSFGGSLVRPEATGYGS DHE2_CLOSY 191 65 -
VLTGKGLEYGGSLTRKEATGYGL O87403 206 65 -
VFTGKGLSFGGSLIRPEATGYGL DHE4_UNKP 193 64 -
VLTGKGLTWGGSLIRPEATGYVS DHE4_DEBOC 181 64 -
VITGKPPSVGGIVARMDATARGA DHE3_THELI 173 67 -
CVTGKPLSKGGIAGRAESTGRGV DHE3_RHISN 156 69 -
RFTGKGISFQGSQMRPEATGYGV O60995 193 64 -
CVTKPGISQGGIHGRISATGRGV DHE3_BOVIN 197 70 -
VFTGKPVELGGIGVRLYSTGLGV DHE3_SULSO 174 65 -
VLTGKNVKWGGSFIRPEATGYGA DHE4_GIALA 190 64 -
RFTGKGISFQGSQMRPEATGYGV O60996 193 64 -
CVTKPGISQGGIHGRISATGRGL DHE3_CHICK 200 70 -
TLTGKGFEFGGSRLRPESTGFGA DHE2_PORGI 189 64 -
VLTGKGLTWGGSLVRTEATGYGC DHE4_CORGL 194 65 -
FITGKPLVLGGSHGRESATAKGV YPCA_BACSU 184 65 -
TFTGKPVAFGGSEGRNEATGFGV DHE2_PEPAS 173 66 -
FITGKPLVLGGSQGRETATAQGV YWEB_BACSU 182 65 -
VLTGKGLTYGGSLCRKEATGYGC DHE4_HELPY 189 64 -
VITGKPPGVGGIVARMDATARGA DHE3_PYRKO 172 67 -
ITGKPIGSAGGIHGRVSATGRGV O02375 234 71 -
YVTGISPEFGSSGNPSPATAYGV DHLE_BACST 132 51 -
FVTGISPAFGSSGNPSPVTAYGV Q53560 132 51 -
YVTGISPAFGSSGNPSPVTAYGV DHLE_BACSU 132 51 -
FVTGISPSFGSSGNPSPVTAYGV Q59194 134 51 -
YVTGVSPAFGSSGNPSPVTAYGV Q60030 132 51 -
WTTGRSPENGGAGDSSVLTAFGV VDH_STRFR 151 56 -
WTTGRSPENGGAGDSSVLTAFGV Q53872 140 51 -
WTTGRSPENGGAGDSSVLTSFGV VDH_STRCO 142 51 -
WTTGRSPENGGAGDSSVLTSFGV O69056 143 51 -
FINGIPEQYGGSGDSSIPTAQGV DHPH_BACSH 143 51 -
SFAGLPKSYGGKGDTSIPTALGV DHPH_THEIN 133 51 -
CIVGVPEAYGGGGDSSIPTAMGV Q59224 142 51 -
YIVGKPVEYGGGGDSSIPTALGV P97014 144 51 -

Motif 3 width=21
Element Seqn Id St Int Rpt
FVIQGFGNVGTWAAKLIHEKG Q38946 209 19 -
FAIQGFGNVGAWAAKLIHERG O04937 209 19 -
FVIQGFGNVGSWVARLIGERG DHE3_VITVI 209 19 -
VAISGSGNVAQYAALKVIELG DHE4_EMENI 224 22 -
VAVQGFGNVGQFAALLISQEL DHE3_THEMA 213 19 -
VSVSGSGNVAQYAIEKAMEFG DHE4_ECOLI 235 19 -
VAVSGSGNVAQYAIEKAMAFG DHE4_SALTY 235 19 -
FVIQGFGNVGSWAAKLISEKG Q43314 209 19 -
FVIQGFGNVGSWAAQLISEAG O04872 209 19 -
FVIQGFGNVGSWAAQLISEAG Q43260 209 19 -
FVIQGFGNVGSWAAKLIHEQG P93541 209 19 -
FVVQGFGNVGLHSMRYLHRFG DHE3_HUMAN 304 27 -
FVVQGFGNVGLHSMRYLHRFG DHE4_HUMAN 304 27 -
FVVQGFGNVGLHSMRYLHRFG DHE3_RAT 304 27 -
FVVQGFGNVGLHSMRYLHRFG DHE3_MOUSE 304 27 -
VAISGFGNVAWGAATKATELG DHE4_BACFR 231 19 -
VALSGSGNVAQYAALKLIELG DHE4_NEUCR 221 20 -
FVIQGFGNVGSWAAQLISEAG O04871 209 19 -
FVVQGFGNVGSWAAQLITEQG O24119 209 19 -
CLVSGSGNVAQYTIEKVIELG DHE4_BACTN 231 19 -
IAVQGIGNVGSYTVLNCEKLG DHE2_CLODI 215 19 -
IAIQGYGNAGYYLAKIMSEDF DHE3_PYRFU 216 20 -
IAIQGYGNAGYYLAKIMSEDY DHE3_PYREN 216 20 -
IAIQGYGNAGYYLAKIMSEDY DHE3_PYRHO 216 20 -
VAISGSGNVGQFTALKVIELG DHE4_LACBI 222 23 -
VTISGSGNVAQYAALKVIELG DHE5_YEAST 221 22 -
VAVQGFGNAGMVVAECLYQDG DHE4_SYNY3 212 19 -
VVVSGSGNVAQYAVEKCLQLG O61083 235 19 -
VSVSGSGNVAQYAIEKALSLG DHE4_HAEIN 235 19 -
VLVSGSGNVAQYTIEKLLQLG DHE4_PRERU 231 19 -
VAVQGYGSVGANAARLLDKWG DHE4_HALSA 234 19 -
IAVQGYGNAGYYTAKLAKEQL O74024 215 19 -
FIVQGFGNVGLHTTRYLTRAG DHE3_DROME 295 27 -
FIVQGFGNVGLHTTRYLTRAG P91624 295 27 -
VTISGSGNVAQYAALKVIELG DHE4_YEAST 220 22 -
AIIQGFGNVGLHTHRYLHRAG Q23621 282 27 -
VAISGSGNVSQFTALKVIELG DHE4_AGABI 222 23 -
VALAGFGNVAWGAAKKLAELG DHE2_CLOSY 233 19 -
VVVSGSGNVALYAMEKAAQFG O87403 248 19 -
VAVSGSGNVAQYTIEKALELD DHE4_UNKP 235 19 -
VELSGSGNVAQYAALKVIELG DHE4_DEBOC 226 22 -
IAIQGYGNAGYYMAKIMSEEY DHE3_THELI 215 19 -
TVIQGFGNVGYHAARFLSEED DHE3_RHISN 205 26 -
VVVSGSGNVAQYAVKKCLQLG O60995 235 19 -
FAVQGFGNVGLHSMRYLHRFG DHE3_BOVIN 247 27 -
VIIQGFGNVGYYAGKFLSEMG DHE3_SULSO 217 20 -
VLLSGSGNVAQFACEKLIQLG DHE4_GIALA 232 19 -
VVVSGSGNVAQYPVEKCLQLG O60996 235 19 -
FAVQGFGNVGLHSMRYLHRFG DHE3_CHICK 250 27 -
LAISGFGNVAWGVAQKATELG DHE2_PORGI 231 19 -
IIVSGSGNVATYAIEKAQELG DHE4_CORGL 236 19 -
VVVQGFGNAGSYLAKFMHDAG YPCA_BACSU 226 19 -
IAVQGFGNVGTFTVKNIERQG DHE2_PEPAS 215 19 -
IIIQGFGNAGSFLAKFMHDAG YWEB_BACSU 224 19 -
CSVSGSGNVAIYTIEKLLQIG DHE4_HELPY 231 19 -
IAIQGYGNAGYYLHKIMSEEF DHE3_PYRKO 215 20 -
IIIQGFGNVGLHTMRYLHRAG O02375 284 27 -
VAVQGVGNVAYHLCRHLHEEG DHLE_BACST 176 21 -
VAVQGVGNVAYNLCRHLHEEG Q53560 176 21 -
IAVQGVGNVAYNLCRHLHEEG DHLE_BACSU 176 21 -
IAVQGVGNVAYHLCKHLHAEG Q59194 178 21 -
VAVQGVGHVAYELCKHLHNEG Q60030 176 21 -
VGVAGVGKVGHHLVDHLVEDG VDH_STRFR 195 21 -
VGVAGVGKVGHHLVEHLLEDG Q53872 184 21 -
VGIAGVGKVGHHLVEHLLAEG VDH_STRCO 186 21 -
VGIAGVGKVGHHLVEHLLAEG O69056 187 21 -
YAIQGLGKVGYKVAEQLLKAG DHPH_BACSH 187 21 -
VAIQGVGKVGERLLQLLVEVG DHPH_THEIN 177 21 -
YAIQGLGKVGYKVAEGLLEEG Q59224 186 21 -
YSIQGLGKVGYKVAEHIINEG P97014 188 21 -

Motif 4 width=12
Element Seqn Id St Int Rpt
ANAGGVTVSYFE Q38946 336 106 -
ANAGGVTVSYFE O04937 336 106 -
ANAGGVTVSYFE DHE3_VITVI 336 106 -
ANAGGVAVSGLE DHE4_EMENI 377 132 -
ANAGGVTVSYFE DHE3_THEMA 341 107 -
ANAGGVATSGLE DHE4_ECOLI 372 116 -
ANAGGVATSGLE DHE4_SALTY 372 116 -
ANSGGVTVSYFE Q43314 336 106 -
ANSGGVTVSYFE O04872 336 106 -
ANSGGVTVSYFE Q43260 336 106 -
ANSGGVTVSYFE P93541 337 107 -
LNAGGVTVSYFE DHE3_HUMAN 430 105 -
LNAGGVTVSYFE DHE4_HUMAN 430 105 -
LNAGGVTVSYFE DHE3_RAT 430 105 -
LNAGGVTVSYFE DHE3_MOUSE 430 105 -
VNAGGVATSGLE DHE4_BACFR 369 117 -
ANCGGVAVSGLE DHE4_NEUCR 368 126 -
ANSGGVTVSYFE O04871 336 106 -
ANSGGVTVSYFE O24119 336 106 -
ANAGGVSVSGLE DHE4_BACTN 368 116 -
TNAGGVTVSYFE DHE2_CLODI 347 111 -
CNAGGVTVSYFE DHE3_PYRFU 344 107 -
CNAGGVTVSYFE DHE3_PYREN 344 107 -
CNAGGVTVSYFE DHE3_PYRHO 344 107 -
SNCGGVAVSGLE DHE4_LACBI 366 123 -
ANLGGVAVSGLE DHE5_YEAST 374 132 -
VNAGGVTVSYFE DHE4_SYNY3 348 115 -
ANAGGVAISGLE O61083 372 116 -
ANAGGVATSGLE DHE4_HAEIN 372 116 -
SNAGGVATSGLE DHE4_PRERU 368 116 -
ANAGGVTVSYFE DHE4_HALSA 360 105 -
CNAGGVTVSYFE O74024 343 107 -
INAGGVTVSFFE DHE3_DROME 422 106 -
INAGGVTVSFFE P91624 422 106 -
ANLGGVAVSGLE DHE4_YEAST 373 132 -
VNSGGVTVSYFE Q23621 411 108 -
SNCGGVAVSGLE DHE4_AGABI 368 125 -
VNAGGVLVSGFE DHE2_CLOSY 372 118 -
ANAGGVAVSALE O87403 384 115 -
ANAAGLATSGLE DHE4_UNKP 371 115 -
ANCGGVAVSGLE DHE4_DEBOC 376 129 -
CNAGGVTVSYFE DHE3_THELI 343 107 -
VNAGGVVVSYFE DHE3_RHISN 334 108 -
ANAXGVAISGLE O60995 372 116 -
LNAGGVTVSYFQ DHE3_BOVIN 373 105 -
ANAGGVVGSYVE DHE3_SULSO 344 106 -
SNAGGVSVSGLE DHE4_GIALA 373 120 -
ANARGVAISGLE O60996 372 116 -
LNAGGVTVSAFZ DHE3_CHICK 376 105 -
VNAGGVSCSGLE DHE2_PORGI 370 118 -
VNVGGVATSALE DHE4_CORGL 391 134 -
ASAGGVTVSYFE YPCA_BACSU 352 105 -
TNSGGVLVSYYE DHE2_PEPAS 347 111 -
ASAGGVTVSYFE YWEB_BACSU 350 105 -
ANAGGVSVSGLE DHE4_HELPY 373 121 -
CNTGGVTVSYFE DHE3_PYRKO 344 108 -
INSGGVTVSYFE O02375 413 108 -
INAGGVINVADE DHLE_BACST 286 89 -
INAGGVINVADE Q53560 286 89 -
INAGGVINVADE DHLE_BACSU 286 89 -
INAGGVINVADE Q59194 288 89 -
INAGGVINVADE Q60030 286 89 -
VNAGGVIQVADE VDH_STRFR 307 91 -
VNAGGVIQVADE Q53872 297 92 -
VNAGGVIQVADE VDH_STRCO 299 92 -
VNAGGVIQVADE O69056 300 92 -
VNAGGLIQVADE DHPH_BACSH 302 94 -
VNAGGLIQVADE DHPH_THEIN 289 91 -
VNSGGLIQVADE Q59224 301 94 -
VNGGGLIQVADE P97014 300 91 -