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PR00070

Identifier
DHFR  [View Relations]  [View Alignment]  
Accession
PR00070
No. of Motifs
4
Creation Date
11-SEP-1993  (UPDATE 28-JUL-1999)
Title
Dihydrofolate reductase signature
Database References

PROSITE; PS00075 DHFR
PFAM; PF00186 DiHfolate_red
INTERPRO; IPR001796
PDB; 1DRF
SCOP; 1DRF
CATH; 1DRF
Literature References
1. TRIMBLE, J.J., MURTHY, S.C.S., BAKKER, A., GRASSMANN, R. AND
DESROSIERS, R.C.
A gene for dihydrofolate reductase in a herpesvirus.
SCIENCE 239 1145-1147 (1988).
 
2. OFFNER, C., DARCY, A. AND WINKLER, F.K.
Crystal structure of human dihydrofolate reductase complexed with folate.
EUR.J.BIOCHEMISTRY 174(2) 377-385 (1988).
 
3. SMITH, S.L., PATRICK, P., STONE, D., PHILLIPS, A.W. AND BURCHALL, J.J.
Porcine liver dihydrofolate reductase.
J.BIOL.CHEM. 254 11475-11484 (1979).
 
4. COWMAN, A.F. AND LEW, A.M.
Antifolate drug selection results in duplication and rearrangement of 
chromosome 7 in Plasmodium chabaudi.
MOL.CELL.BIOL. 9(11) 5182-5188 (1989).

Documentation
Dihydrofolate reductase (DHFR) catalyses the NADPH-dependent reduction of
dihydrofolate to tetrahydrofolate, an essential step in de novo synthesis
both of glycine and of purines and deoxythymidine phosphate (the precursors
of DNA synthesis) [1], and important also in the conversion of deoxyuridine
monophosphate to deoxythymidine monophosphate. Although DHFR is found
ubiquitously in prokaryotes and eukaryotes, and is found in all dividing
cells, maintaining levels of fully reduced folate coenzymes, the catabolic
steps are still not well understood [2].
 
Bacterial species possesses distinct DHFR enzymes (based on their pattern
of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly
similar [3]. The active site is situated in the N-terminal half of the
sequence, which is the area of least variability. Its central role in DNA
precursor synthesis, coupled with its inhibition by antagonists such as
trimethoprim and methotrexate, which are used as anti-bacterial or anti-
cancer agents, has made DHFR a target of anticancer chemotherapy. However,
resistance has developed against some drugs, as a result of changes in DHFR
itself [4].
 
DHFR is a 4-element fingerprint that provides a signature for DHFRs. The
fingerprint was derived from an initial alignment of 11 sequences: the
motifs line the active site, motif 1 including the region encoded by
PROSITE pattern DHFR (PS00075), in which the conserved Trp is implicated
in substrate binding. Two iterations on OWL21.1 were required to reach
convergence, at which point a true set comprising 55 sequences was
identified. Nine partial matches were also found, all of which are
fragments.
 
An update on SPTR37_9f identified a true set of 77 sequences, and 9
partial matches.
Summary Information
  77 codes involving  4 elements
6 codes involving 3 elements
3 codes involving 2 elements
Composite Feature Index
477777777
36066
21032
1234
True Positives
DRT1_ARATH    DRT2_ARATH    DRTS_CRIFA    DRTS_DAUCA    
DRTS_LEIAM DRTS_LEIMA DRTS_PARTE DRTS_PLABA
DRTS_PLACH DRTS_PLAFK DRTS_SOYBN DRTS_TOXGO
DRTS_TRYBB DRTS_TRYCR DYR1_ECOLI DYR3_SALTY
DYR5_ECOLI DYR6_PROMI DYR7_ECOLI DYR8_ECOLI
DYR9_ECOLI DYRA_ECOLI DYRA_STAAU DYRC_ECOLI
DYRF_ECOLI DYR_AEDAL DYR_BACSU DYR_BOVIN
DYR_BPT4 DYR_CAEEL DYR_CANAL DYR_CHICK
DYR_CITFR DYR_CRYNE DYR_DROME DYR_ECOLI
DYR_ENTAE DYR_ENTFC DYR_HAEIN DYR_HSVS7
DYR_HSVSA DYR_HSVSC DYR_HUMAN DYR_KLEAE
DYR_LACCA DYR_LACLA DYR_MESAU DYR_MOUSE
DYR_MYCGE DYR_MYCPN DYR_NEIGO DYR_PIG
DYR_PNECA DYR_SCHPO DYR_STAEP DYR_STRPN
DYR_YEAST O15873 O30463 O33305
O40919 O59840 O74408 O81395
O85255 O85258 O85260 O85261
O85262 O85263 P90486 Q05170
Q27552 Q39687 Q46718 Q46750
Q59137
True Positive Partials
Codes involving 3 elements
DYRB_STAAU DYR_HALVO DYR_STAHA O62583
O85802 Q57426
Codes involving 2 elements
DYR_THEMA O84618 Y213_MYCPN
Sequence Titles
DRT1_ARATH  BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE 1 (DHFR-TS) [INCLUDES: DIHYDROFOLATE REDUCTASE (EC 1.5.1.3); THYMIDYLATE SYNTHASE (EC 2.1.1.45)] - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). 
DRT2_ARATH BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE 2 (DHFR-TS) [INCLUDES: DIHYDROFOLATE REDUCTASE (EC 1.5.1.3); THYMIDYLATE SYNTHASE (EC 2.1.1.45)] - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
DRTS_CRIFA BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS) [INCLUDES: DIHYDROFOLATE REDUCTASE (EC 1.5.1.3); THYMIDYLATE SYNTHASE (EC 2.1.1.45)] - CRITHIDIA FASCICULATA.
DRTS_DAUCA BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS) [INCLUDES: DIHYDROFOLATE REDUCTASE (EC 1.5.1.3); THYMIDYLATE SYNTHASE (EC 2.1.1.45)] - DAUCUS CAROTA (CARROT).
DRTS_LEIAM BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS) [INCLUDES: DIHYDROFOLATE REDUCTASE (EC 1.5.1.3); THYMIDYLATE SYNTHASE (EC 2.1.1.45)] - LEISHMANIA AMAZONENSIS.
DRTS_LEIMA BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS) [INCLUDES: DIHYDROFOLATE REDUCTASE (EC 1.5.1.3); THYMIDYLATE SYNTHASE (EC 2.1.1.45)] - LEISHMANIA MAJOR.
DRTS_PARTE BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS) [INCLUDES: DIHYDROFOLATE REDUCTASE (EC 1.5.1.3); THYMIDYLATE SYNTHASE (EC 2.1.1.45)] - PARAMECIUM TETRAURELIA.
DRTS_PLABA BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS) [INCLUDES: DIHYDROFOLATE REDUCTASE (EC 1.5.1.3); THYMIDYLATE SYNTHASE (EC 2.1.1.45)] - PLASMODIUM BERGHEI (STRAIN ANKA).
DRTS_PLACH BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS) [INCLUDES: DIHYDROFOLATE REDUCTASE (EC 1.5.1.3); THYMIDYLATE SYNTHASE (EC 2.1.1.45)] - PLASMODIUM CHABAUDI.
DRTS_PLAFK BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS) [INCLUDES: DIHYDROFOLATE REDUCTASE (EC 1.5.1.3); THYMIDYLATE SYNTHASE (EC 2.1.1.45)] - PLASMODIUM FALCIPARUM (ISOLATE K1 / THAILAND).
DRTS_SOYBN BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS) [INCLUDES: DIHYDROFOLATE REDUCTASE (EC 1.5.1.3); THYMIDYLATE SYNTHASE (EC 2.1.1.45)] - GLYCINE MAX (SOYBEAN).
DRTS_TOXGO BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS) [INCLUDES: DIHYDROFOLATE REDUCTASE (EC 1.5.1.3); THYMIDYLATE SYNTHASE (EC 2.1.1.45)] - TOXOPLASMA GONDII.
DRTS_TRYBB BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS) [INCLUDES: DIHYDROFOLATE REDUCTASE (EC 1.5.1.3); THYMIDYLATE SYNTHASE (EC 2.1.1.45)] - TRYPANOSOMA BRUCEI BRUCEI.
DRTS_TRYCR BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS) [INCLUDES: DIHYDROFOLATE REDUCTASE (EC 1.5.1.3); THYMIDYLATE SYNTHASE (EC 2.1.1.45)] - TRYPANOSOMA CRUZI.
DYR1_ECOLI DIHYDROFOLATE REDUCTASE TYPE I (EC 1.5.1.3) (TRIMETHOPRIM RESISTANCE PROTEIN) - ESCHERICHIA COLI.
DYR3_SALTY DIHYDROFOLATE REDUCTASE TYPE III (EC 1.5.1.3) - SALMONELLA TYPHIMURIUM.
DYR5_ECOLI DIHYDROFOLATE REDUCTASE TYPE V (EC 1.5.1.3) - ESCHERICHIA COLI.
DYR6_PROMI DIHYDROFOLATE REDUCTASE TYPE VI (EC 1.5.1.3) - PROTEUS MIRABILIS.
DYR7_ECOLI DIHYDROFOLATE REDUCTASE TYPE VII (EC 1.5.1.3) - ESCHERICHIA COLI.
DYR8_ECOLI DIHYDROFOLATE REDUCTASE TYPE VIII (EC 1.5.1.3) (DHFR TYPE IIIC) - ESCHERICHIA COLI, AND SHIGELLA SONNEI.
DYR9_ECOLI DIHYDROFOLATE REDUCTASE TYPE IX (EC 1.5.1.3) - ESCHERICHIA COLI.
DYRA_ECOLI DIHYDROFOLATE REDUCTASE TYPE X (EC 1.5.1.3) - ESCHERICHIA COLI.
DYRA_STAAU DIHYDROFOLATE REDUCTASE TYPE I (EC 1.5.1.3) (TN4003) - STAPHYLOCOCCUS AUREUS.
DYRC_ECOLI DIHYDROFOLATE REDUCTASE TYPE XIII (EC 1.5.1.3) - ESCHERICHIA COLI.
DYRF_ECOLI DIHYDROFOLATE REDUCTASE TYPE XV (EC 1.5.1.3) - ESCHERICHIA COLI.
DYR_AEDAL DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - AEDES ALBOPICTUS (FOREST DAY MOSQUITO).
DYR_BACSU DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - BACILLUS SUBTILIS.
DYR_BOVIN DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - BOS TAURUS (BOVINE).
DYR_BPT4 DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - BACTERIOPHAGE T4.
DYR_CAEEL PUTATIVE DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - CAENORHABDITIS ELEGANS.
DYR_CANAL DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - CANDIDA ALBICANS (YEAST).
DYR_CHICK DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - GALLUS GALLUS (CHICKEN).
DYR_CITFR DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - CITROBACTER FREUNDII.
DYR_CRYNE DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - CRYPTOCOCCUS NEOFORMANS (FILOBASIDIELLA NEOFORMANS).
DYR_DROME DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - DROSOPHILA MELANOGASTER (FRUIT FLY).
DYR_ECOLI DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - ESCHERICHIA COLI.
DYR_ENTAE DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - ENTEROBACTER AEROGENES (AEROBACTER AEROGENES).
DYR_ENTFC DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - ENTEROCOCCUS FAECIUM (STREPTOCOCCUS FAECIUM).
DYR_HAEIN DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - HAEMOPHILUS INFLUENZAE.
DYR_HSVS7 DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) (DHFR) - HERPESVIRUS SAIMIRI (STRAIN 484-77).
DYR_HSVSA DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) (DHFR) - HERPESVIRUS SAIMIRI (STRAIN 11).
DYR_HSVSC DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - HERPESVIRUS SAIMIRI (SUBGROUP C / STRAIN 488).
DYR_HUMAN DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - HOMO SAPIENS (HUMAN).
DYR_KLEAE DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - KLEBSIELLA AEROGENES.
DYR_LACCA DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - LACTOBACILLUS CASEI.
DYR_LACLA DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - LACTOCOCCUS LACTIS (SUBSP. LACTIS) (STREPTOCOCCUS LACTIS).
DYR_MESAU DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
DYR_MOUSE DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - MUS MUSCULUS (MOUSE).
DYR_MYCGE DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - MYCOPLASMA GENITALIUM.
DYR_MYCPN DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - MYCOPLASMA PNEUMONIAE.
DYR_NEIGO DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - NEISSERIA GONORRHOEAE.
DYR_PIG DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - SUS SCROFA (PIG).
DYR_PNECA DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - PNEUMOCYSTIS CARINII.
DYR_SCHPO DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
DYR_STAEP DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) (DHFR) - STAPHYLOCOCCUS EPIDERMIDIS.
DYR_STRPN DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - STREPTOCOCCUS PNEUMONIAE.
DYR_YEAST DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
O15873 DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHETASE - PLASMODIUM VIVAX.
O30463 DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - MYCOBACTERIUM AVIUM.
O33305 DIHYDROFOLATE REDUCTASE - MYCOBACTERIUM TUBERCULOSIS.
O40919 ORF 02 - KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS (KSHV) (HUMAN HERPESVIRUS 8).
O59840 DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - CANDIDA ALBICANS (YEAST).
O74408 DIHYDROFOLATE REDUCTASE - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O81395 BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE - ZEA MAYS (MAIZE).
O85255 DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - STREPTOCOCCUS PNEUMONIAE.
O85258 DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - STREPTOCOCCUS PNEUMONIAE.
O85260 DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - STREPTOCOCCUS PNEUMONIAE.
O85261 DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - STREPTOCOCCUS PNEUMONIAE.
O85262 DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - STREPTOCOCCUS PNEUMONIAE.
O85263 DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - STREPTOCOCCUS PNEUMONIAE.
P90486 ORF 2 - KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS (KSHV) (HUMAN HERPESVIRUS 8).
Q05170 DIHYDROFOLATE REDUCTASE TYPE XII (EC 1.5.1.3) (TRIMETHOPRIM RESISTANCE PROTEIN) (DHFR) - ESCHERICHIA COLI.
Q27552 BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE - CRYPTOSPORIDIUM PARVUM.
Q39687 DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHETASE PRECURSOR - DAUCUS CAROTA (CARROT).
Q46718 DIHYDROFOLATE REDUCTASE TYPE IB - ESCHERICHIA COLI.
Q46750 DIHYDROFOLATE REDUCTASE TYPE IB - ESCHERICHIA COLI.
Q59137 DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) (TETRAHYDROFOLATE DEHYDROGENASE) - ESCHERICHIA COLI.

DYRB_STAAU DIHYDROFOLATE REDUCTASE TYPE I (EC 1.5.1.3) - STAPHYLOCOCCUS AUREUS.
DYR_HALVO DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - HALOBACTERIUM VOLCANII (HALOFERAX VOLCANII).
DYR_STAHA DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) - STAPHYLOCOCCUS HAEMOLYTICUS.
O62583 DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) (TETRAHYDROFOLATE DEHYDROGENASE) - ENCEPHALITOZOON CUNICULI.
O85802 TRIMETHOPRIM RESISTANT DIHYDROFOLATE REDUCTASE - SALMONELLA TYPHIMURIUM.
Q57426 DIHYDROFOLATE REDUCTASE - STAPHYLOCOCCUS HAEMOLYTICUS, AND LISTERIA MONOCYTOGENES.

DYR_THEMA DIHYDROFOLATE REDUCTASE (EC 1.5.1.3) (DHFR) - THERMOTOGA MARITIMA.
O84618 DIHYDROFOLATE REDUCTASE - CHLAMYDIA TRACHOMATIS.
Y213_MYCPN HYPOTHETICAL PROTEIN MG213 HOMOLOG - MYCOPLASMA PNEUMONIAE.
Scan History
OWL21_1    2  100  NSINGLE    
OWL25_2 1 170 NSINGLE
SPTR37_9f 3 120 NSINGLE
Initial Motifs
Motif 1  width=11
Element Seqn Id St Int Rpt
GIGKNGDLPWP DYR_HUMAN 15 15 -
GIGFRGGVPWR DYR_YEAST 20 20 -
GIGDGESIPWR DRTS_LEIAM 38 38 -
VIGNGPDIPWS DYRB_ECOLI 14 14 -
LIGKDGHLPWH N_3DFR 12 12 -
AFGLGDGLPWG DYR_BPT4 21 21 -
GLGNEGGLPWK DRTS_PLACH 36 36 -
CIGAGNAMPWH DYR_NEIGO 15 15 -
GIGRSNSLPWK DYR_PNECA 18 18 -
GIGKQGNLPWP DYR_HSVSA 16 16 -

Motif 2 width=9
Element Seqn Id St Int Rpt
DMAFFKDQT DRTS_LEIAM 52 3 -
DLHYFRAQT N_3DFR 26 3 -
EQLLFKAIT DYRB_ECOLI 28 3 -
EISYFKRVT DYR_PNECA 32 3 -
DFKHFQRMT DYR_HSVSA 31 4 -
EFRYFQRMT DYR_HUMAN 30 4 -
EMKYFRQVT DYR_YEAST 34 3 -
DFAFFKVYT DYR_NEIGO 29 3 -
DMKHFSSVT DRTS_PLACH 51 4 -
DLQNFKART DYR_BPT4 36 4 -

Motif 3 width=12
Element Seqn Id St Int Rpt
MVVGRRTYESFP N_3DFR 39 4 -
VLMGRKTWESIP DYR_PNECA 55 14 -
VIMGKKTWFSIP DYR_HSVSA 51 11 -
VIMGKKTWFSIP DYR_HUMAN 50 11 -
LIMGRKTWESIP DYR_YEAST 54 11 -
VVMGRKTWESVP DRTS_LEIAM 77 16 -
VIMGRKTWESLP DYR_NEIGO 42 4 -
VVMGKASWESIP DRTS_PLACH 100 40 -
MIMGAKTFQSLP DYR_BPT4 49 4 -
LLVGRKTFESMG DYRB_ECOLI 41 4 -

Motif 4 width=15
Element Seqn Id St Int Rpt
MVWIVGGSSVYKEAM DYR_HUMAN 111 49 -
EAVIMGGAQIYGQAM DYR_NEIGO 94 40 -
KCFIIGGASVYKEFL DRTS_PLACH 161 49 -
KVSVIGGPALLYAAL DYR_BPT4 123 62 -
RIYVIGGGEVYSQIF DYR_YEAST 118 52 -
RIFVIGGAQLYKAAM DYR_PNECA 119 52 -
HVIVSGGGEIYKSLI DYRB_ECOLI 93 40 -
ELVIAGGAQIFTAFK N_3DFR 93 42 -
TAYCVGGAQVYADAM DRTS_LEIAM 152 63 -
MVWIIGGSSVYKEAM DYR_HSVSA 112 49 -
Final Motifs
Motif 1  width=11
Element Seqn Id St Int Rpt
GIGKDGKLPWR DRTS_DAUCA 35 35 -
GIGKDGKLPWR Q39687 84 84 -
GIGKDGKLPWR DRTS_SOYBN 38 38 -
GIGKDGKLPWN DRT2_ARATH 30 30 -
GIGKDGVLPWK O81395 29 29 -
GIGKDGKLPWN DRT1_ARATH 33 33 -
GIGKNGDLPWP DYR_MOUSE 15 15 -
GIGKNGDLPWP DYR_PIG 15 15 -
GIGKNGDLPWP DYR_BOVIN 15 15 -
GIGRSNSLPWK DYR_PNECA 18 18 -
GIGYKGKMPWR DYR_CANAL 18 18 -
GIGYKGKMPWR O59840 18 18 -
GIGKQGNLPWP DYR_HSVSA 16 16 -
GIGKNGDFPWP DYR_MESAU 15 15 -
LIGKDNLIPWH DYR3_SALTY 14 14 -
GIGDGGTIPWE DRTS_TRYBB 40 40 -
GIGINNGLPWP DRTS_TOXGO 16 16 -
GIGDGRSIPWN DRTS_TRYCR 34 34 -
GIGLNGGLPWR DYR_CRYNE 23 23 -
LIGKDNDLPWH DYR_BACSU 13 13 -
GIGKNGDLPWP DYR_HUMAN 15 15 -
GIGKNGYLPWP DYR_HSVS7 16 16 -
VIGRGGDIPWS O30463 17 17 -
GIGKKGHLPWP DYR_HSVSC 16 16 -
GIGKNGVLPWR DYR_CAEEL 15 15 -
GIGNAGVLPWK DRTS_PLABA 36 36 -
GIGKDGNLPWP DYR_CHICK 15 15 -
GIGKNRCLPWP P90486 16 16 -
GIGKNRCLPWP O40919 16 16 -
VIGMENAMPWN DYR_KLEAE 13 13 -
GIGINGQLPWS Q27552 18 18 -
VIGMENAMPWN DYR_ECOLI 13 13 -
VIGMENAMPWN DYR_CITFR 13 13 -
VIGMENAMPWD DYR_ENTAE 13 13 -
GIGIRGDLPWR DYR_DROME 15 15 -
VIGNGPNIPWK Q05170 19 19 -
GIGFRGGVPWR DYR_YEAST 20 20 -
CIGKDNALPWP DYR8_ECOLI 15 15 -
GIGIKGDLPWR DYR_AEDAL 15 15 -
GIGFENQIPWH DYR9_ECOLI 15 15 -
GIGDGESIPWR DRTS_LEIAM 38 38 -
GLGNKGVLPWK DRTS_PLAFK 39 39 -
GIGYQNRLPWK DRTS_PARTE 18 18 -
GLGNKGTLPWK O15873 38 38 -
VIGRGGDIPWR O33305 13 13 -
GIGDGESIPWR DRTS_LEIMA 38 38 -
VIGKDNQMPWH DYR_HAEIN 14 14 -
CIGAGNAMPWH DYR_NEIGO 15 15 -
VIGNGPDIPWK DYRC_ECOLI 19 19 -
VIGKDNRLPWH O85263 16 16 -
LIGNNNTLPWM DYR_MYCGE 13 13 -
VIGKDNRLPWH O85260 16 16 -
GLGNEGGLPWK DRTS_PLACH 36 36 -
VIGCGPDIPWS Q46750 14 14 -
VIGCGPDIPWS Q46718 14 14 -
VIGKENRLPWH DYR_STRPN 16 16 -
VIGKDNRLPWH O85258 16 16 -
GIGKKNSMPWH DYR_SCHPO 246 246 -
GIGKKNSMPWH O74408 246 246 -
VIGCGPHIPWS DYR5_ECOLI 14 14 -
VIGKDNRLPWY O85255 16 16 -
VIGKDNRLPWH O85262 16 16 -
VIGNGPDIPWS DYR1_ECOLI 14 14 -
VIGNGPDIPWS DYRF_ECOLI 14 14 -
VIGNGPDIPWS Q59137 9 9 -
VIGSGLDIPWH DYR6_PROMI 14 14 -
GIGDGETIPWT DRTS_CRIFA 38 38 -
VIGNGPDIPWS DYR7_ECOLI 14 14 -
VIGKDNRLPWY O85261 16 16 -
LIGKDGLLPWR DYR_ENTFC 13 13 -
LIGNGNSLPWR DYR_MYCPN 13 13 -
VIGYQNQLPWH DYR_STAEP 14 14 -
VIGYQNQLPWH DYRA_STAAU 13 13 -
LIGKDGHLPWH DYR_LACCA 12 12 -
LIGEADKMPWS DYR_LACLA 13 13 -
AFGLGDGLPWG DYR_BPT4 21 21 -
AFGNQGKLPWQ DYRA_ECOLI 15 15 -

Motif 2 width=9
Element Seqn Id St Int Rpt
DMKFFKDVT DRTS_DAUCA 49 3 -
DMKFFKDVT Q39687 98 3 -
DLKFFKEIT DRTS_SOYBN 52 3 -
DLKFFKDLT DRT2_ARATH 44 3 -
DLKFFKELT O81395 43 3 -
DLKFFKDIT DRT1_ARATH 47 3 -
EFKYFQRMT DYR_MOUSE 30 4 -
EYKYFQRMT DYR_PIG 30 4 -
EFQYFQRMT DYR_BOVIN 30 4 -
EISYFKRVT DYR_PNECA 32 3 -
EIRYFKDVT DYR_CANAL 32 3 -
EIRYFKDVT O59840 32 3 -
DFKHFQRMT DYR_HSVSA 31 4 -
EFKYFQRMT DYR_MESAU 30 4 -
DLRHFKAVT DYR3_SALTY 28 3 -
DMQYFRRVT DRTS_TRYBB 54 3 -
DFKHFSRVT DRTS_TOXGO 31 4 -
DMKFFRDLT DRTS_TRYCR 48 3 -
EMKYFARVT DYR_CRYNE 37 3 -
DLAYFKKIT DYR_BACSU 27 3 -
EFRYFQRMT DYR_HUMAN 30 4 -
DFKYFQRMT DYR_HSVS7 31 4 -
DLTRFKEVT O30463 31 3 -
DFKYFQRMT DYR_HSVSC 31 4 -
DMQYFASVT DYR_CAEEL 29 3 -
DMKYFSSVT DRTS_PLABA 51 4 -
EYKYFQRMT DYR_CHICK 30 4 -
DMRRFRQLT P90486 31 4 -
DMRRFRQLT O40919 31 4 -
DLAWFKRNT DYR_KLEAE 27 3 -
DLKFFSKIT Q27552 32 3 -
DLAWFKRNT DYR_ECOLI 27 3 -
DLAWFKRNT DYR_CITFR 27 3 -
DLAWFKRNT DYR_ENTAE 27 3 -
ELKYFSRTT DYR_DROME 29 3 -
EQKIFRRLT Q05170 33 3 -
EMKYFRQVT DYR_YEAST 34 3 -
DLARFKKLT DYR8_ECOLI 30 4 -
ELKYFSRMT DYR_AEDAL 29 3 -
DLKHFKAVT DYR9_ECOLI 29 3 -
DMAFFKDQT DRTS_LEIAM 52 3 -
DMKYFRAVT DRTS_PLAFK 54 4 -
DLQRFKKIT DRTS_PARTE 32 3 -
DMKYFSSVT O15873 53 4 -
DQAHFREIT O33305 27 3 -
DMTFFKNQT DRTS_LEIMA 52 3 -
DLAWFRQNT DYR_HAEIN 28 3 -
DFAFFKVYT DYR_NEIGO 29 3 -
EQKIFRRLT DYRC_ECOLI 33 3 -
ELQHFKETT O85263 30 3 -
ELAHFKKTT DYR_MYCGE 27 3 -
ELQHFKETT O85260 30 3 -
DMKHFSSVT DRTS_PLACH 51 4 -
EQLLFKALT Q46750 28 3 -
EQLLFKALT Q46718 28 3 -
ELQHFKETT DYR_STRPN 30 3 -
ELQHFKETT O85258 30 3 -
EMAYFANVT DYR_SCHPO 260 3 -
EMAYFANVT O74408 260 3 -
EQLLFKALT DYR5_ECOLI 28 3 -
ELQHFKETT O85255 30 3 -
ELQHFKETT O85262 30 3 -
EQLLFKAIT DYR1_ECOLI 28 3 -
EQLLFKAIT DYRF_ECOLI 28 3 -
EQLLFKAIT Q59137 23 3 -
EQLLFKAMT DYR6_PROMI 28 3 -
TLAFFKDQT DRTS_CRIFA 52 3 -
EQLLFKALT DYR7_ECOLI 28 3 -
ELQHFKETT O85261 30 3 -
DMRFFREHT DYR_ENTFC 27 3 -
ELQHFRQTT DYR_MYCPN 27 3 -
DLKHVKQLT DYR_STAEP 28 3 -
DLKHIKQLT DYRA_STAAU 27 3 -
DLHYFRAQT DYR_LACCA 26 3 -
EQKHFKETT DYR_LACLA 27 3 -
DLQNFKART DYR_BPT4 36 4 -
DMQFFQKTT DYRA_ECOLI 30 4 -

Motif 3 width=12
Element Seqn Id St Int Rpt
VIMGRKTWESIP DRTS_DAUCA 69 11 -
VIMGRKTWESIP Q39687 118 11 -
IVMGRKTWESIP DRTS_SOYBN 72 11 -
VVMGRKTWESIP DRT2_ARATH 64 11 -
VIMGRKTWESIP O81395 63 11 -
VVMGRKTWESIP DRT1_ARATH 67 11 -
VIMGRKTWFSIP DYR_MOUSE 50 11 -
VIMGRKTWFSIP DYR_PIG 50 11 -
VIMGRKTWFSIP DYR_BOVIN 50 11 -
VLMGRKTWESIP DYR_PNECA 55 14 -
VIMGRKTWESIP DYR_CANAL 52 11 -
VIMGRKTWESIP O59840 52 11 -
VIMGKKTWFSIP DYR_HSVSA 51 11 -
VIMGRKTWFSIP DYR_MESAU 50 11 -
VVMGRRTFESIG DYR3_SALTY 41 4 -
VVMGRKTWDSLP DRTS_TRYBB 80 17 -
VVMGRKTWESMP DRTS_TOXGO 77 37 -
VVMGRKTWDSIP DRTS_TRYCR 74 17 -
VIMGRKTWESIP DYR_CRYNE 60 14 -
IIMGRKTFESIG DYR_BACSU 40 4 -
VIMGKKTWFSIP DYR_HUMAN 50 11 -
VIMGKNTWFSIP DYR_HSVS7 50 10 -
VIMGRRTWESLP O30463 44 4 -
VIMGKNTWFSIP DYR_HSVSC 50 10 -
VLMGRKCWESIP DYR_CAEEL 49 11 -
VVMGKKSWESIP DRTS_PLABA 104 44 -
VIMGKKTWFSIP DYR_CHICK 50 11 -
VVMGRRTWLSIP P90486 50 10 -
VVMGRRTWLSIP O40919 50 10 -
VVMGRLTWESIG DYR_KLEAE 40 4 -
LIMGRKTWDSIG Q27552 52 11 -
VIMGRHTWESIG DYR_ECOLI 40 4 -
VVMGRHTWESIG DYR_CITFR 40 4 -
VVMGRLTWESIG DYR_ENTAE 40 4 -
VVMGRKTYFGVP DYR_DROME 49 11 -
VVMGRKTFESIG Q05170 46 4 -
LIMGRKTWESIP DYR_YEAST 54 11 -
VIMGRKTYESLP DYR8_ECOLI 43 4 -
IIMGRKTYFGVP DYR_AEDAL 49 11 -
LIMGRKTFASLP DYR9_ECOLI 42 4 -
VVMGRKTWESVP DRTS_LEIAM 77 16 -
VVMGRTNWESIP DRTS_PLAFK 102 39 -
VIMGRKTFESMN DRTS_PARTE 45 4 -
VVMGRSSWESIP O15873 111 49 -
IVMGRRTWDSLP O33305 40 4 -
VVMGRKTWESVP DRTS_LEIMA 77 16 -
VIMGRKTFESIG DYR_HAEIN 41 4 -
VIMGRKTWESLP DYR_NEIGO 42 4 -
VVMGRKTFESIG DYRC_ECOLI 46 4 -
ILMGRVTFDGMG O85263 43 4 -
LLMGRKTYESLP DYR_MYCGE 40 4 -
ILMGRVTFDGMG O85260 43 4 -
VVMGKASWESIP DRTS_PLACH 100 40 -
LLVGRKTFESMG Q46750 41 4 -
LLVGRKTFESMG Q46718 41 4 -
ILMGRVTFDGMG DYR_STRPN 43 4 -
ILMGRVTFDGIG O85258 43 4 -
VIMGRSCYDSLP DYR_SCHPO 288 19 -
VIMGRSCYDSLP O74408 288 19 -
LLVGRKTFESMG DYR5_ECOLI 41 4 -
ILMGRVTFDGIG O85255 43 4 -
ILMGRVTFDGMG O85262 43 4 -
LLVGRKTFESMG DYR1_ECOLI 41 4 -
LLVGRKTFESMG DYRF_ECOLI 41 4 -
LLVGRKTFESMG Q59137 36 4 -
LLVGRKTFDSMG DYR6_PROMI 41 4 -
VVMGRKTWEVPL DRTS_CRIFA 77 16 -
LLVGRKTFDSMG DYR7_ECOLI 41 4 -
ILMGRVTFDGME O85261 43 4 -
LVMGRKTYEGMG DYR_ENTFC 40 4 -
VLMGSATYLSLP DYR_MYCPN 40 4 -
LVMGRKTFNSIG DYR_STAEP 41 4 -
LVMARKTFNSIG DYRA_STAAU 40 4 -
MVVGRRTYESFP DYR_LACCA 39 4 -
ILMGRKTFEGMN DYR_LACLA 40 4 -
MIMGAKTFQSLP DYR_BPT4 49 4 -
VVMGLNTWRSLP DYRA_ECOLI 43 4 -

Motif 4 width=15
Element Seqn Id St Int Rpt
KVFVIGGGQIYREAL DRTS_DAUCA 132 51 -
KVFVIGGGQIYREAL Q39687 181 51 -
KVFVIGGGQIFREAL DRTS_SOYBN 135 51 -
KVFVIGGGDILREAL DRT2_ARATH 127 51 -
KVFVIGGGQVLREYL O81395 126 51 -
RVFVIGGGDILREAL DRT1_ARATH 130 51 -
MVWIVGGSSVYQEAM DYR_MOUSE 111 49 -
MVWIVGGSSVYKEAM DYR_PIG 111 49 -
VVWIVGGSSVYKEAM DYR_BOVIN 111 49 -
RIFVIGGAQLYKAAM DYR_PNECA 119 52 -
RVFIIGGAEIYNELI DYR_CANAL 108 44 -
RVFIIGGAEIYNELI O59840 108 44 -
MVWIIGGSSVYKEAM DYR_HSVSA 112 49 -
MVWIVGGSSVYKEAM DYR_MESAU 111 49 -
EAMIIGGGQLYAEAL DYR3_SALTY 92 39 -
TVFCIGGGTIYKQAL DRTS_TRYBB 156 64 -
QIFVVGGAGLYEAAL DRTS_TOXGO 147 58 -
TVYCIGGGSVYAEAL DRTS_TRYCR 150 64 -
RIFLIGGATLYTSSL DYR_CRYNE 122 50 -
ECFVIGGAQLYTDLF DYR_BACSU 91 39 -
MVWIVGGSSVYKEAM DYR_HUMAN 111 49 -
MVWIIGGSSVYKDAM DYR_HSVS7 111 49 -
APWVIGGAQIYLLAL O30463 98 42 -
RVWIIGGSSVYKDAM DYR_HSVSC 111 49 -
TIWNIGGAEIYDLAL DYR_CAEEL 110 49 -
KCFIIGGSSVYKEFL DRTS_PLABA 169 53 -
MVWIVGGTAVYKAAM DYR_CHICK 111 49 -
KVWVIGGGDLYREAL P90486 111 49 -
KVWVIGGGNLYREAL O40919 111 49 -
EIMVIGGGRVYDEFL DYR_KLEAE 90 38 -
NIFVCGGESIYRDAL Q27552 109 45 -
EIMVIGGGRVYEQFL DYR_ECOLI 90 38 -
EIMVIGGGRVYEQFL DYR_CITFR 90 38 -
EIMVIGGGRVYEQFL DYR_ENTAE 90 38 -
NIWIVGGSGVYEEAM DYR_DROME 108 47 -
ELYVAGGAEIYTLAL Q05170 98 40 -
RIYVIGGGEVYSQIF DYR_YEAST 118 52 -
VAYVIGGAEIFKRLA DYR8_ECOLI 102 47 -
NVWIVGGNAVYKEAM DYR_AEDAL 111 50 -
QIFVIGGKSAYENLA DYR9_ECOLI 101 47 -
TAYCVGGAQVYADAM DRTS_LEIAM 152 63 -
KCFIIGGSVVYQEFL DRTS_PLAFK 160 46 -
KLYLIGGKRIFEEGL DRTS_PARTE 97 40 -
KCFIIGGAQVYRECL O15873 169 46 -
ETWVIGGGQVYALAL O33305 90 38 -
TAYCVGGAQVYADAM DRTS_LEIMA 152 63 -
EIMLIGGGELFKQYL DYR_HAEIN 91 38 -
EAVIMGGAQIYGQAM DYR_NEIGO 94 40 -
ELYVARGAEVYALAL DYRC_ECOLI 98 40 -
NLYILGGKQIYQAFE O85263 96 41 -
DLFICGGKSVYEQTI DYR_MYCGE 97 45 -
NLYIIGGKQIFQAFE O85260 96 41 -
KCFIIGGASVYKEFL DRTS_PLACH 161 49 -
HVIVSGGGEIYRETL Q46750 93 40 -
HVIVSGGGEIYRETL Q46718 93 40 -
NLYIIGGKQIFQAFE DYR_STRPN 96 41 -
NLYILGGKQIFQAFE O85258 96 41 -
KVFIIGGSFLYGSAL DYR_SCHPO 360 60 -
KVFIIGGSFLYGSAL O74408 360 60 -
HVIVSGGGEIYRETL DYR5_ECOLI 93 40 -
NLYILGGKQIFQAFE O85255 96 41 -
NLYILGGKQIFQAFE O85262 96 41 -
HVIVSGGGEIYKSLI DYR1_ECOLI 93 40 -
HVIVSGGGEIYKSLI DYRF_ECOLI 93 40 -
HVIVSGGGEIYKSLI Q59137 88 40 -
HIFVSGGGEIYKALI DYR6_PROMI 93 40 -
TAYCIGGARVYTEAM DRTS_CRIFA 150 61 -
HLYVSGGGQIYNSLI DYR7_ECOLI 93 40 -
NLYILGGKQIFQAFE O85261 96 41 -
DIYVSGGSRIFQALL DYR_ENTFC 94 42 -
HLYICGGAQVYEQLI DYR_MYCPN 97 45 -
HVFIFGGQTLFEAMI DYR_STAEP 89 36 -
HVFIFGGQTLYEAMI DYRA_STAAU 88 36 -
ELVIAGGAQIFTAFK DYR_LACCA 93 42 -
DLFITGGAEILALFE DYR_LACLA 95 43 -
KVSVIGGPALLYAAL DYR_BPT4 123 62 -
PINVIGGVGLLSEAI DYRA_ECOLI 99 44 -