WORKLIST ENTRIES (1): WNT6PROTEIN View alignment Wnt-6 protein signature Type of fingerprint: COMPOUND with 3 elements Links: PRINTS; PR01349 WNTPROTEIN PRINTS; PR01841 WNT1PROTEIN; PR01842 WNT2PROTEIN; PR01843 WNT3PROTEIN PRINTS; PR01844 WNT4PROTEIN; PR01891 WNT7PROTEIN; PR01892 WNT8PROTEIN PRINTS; PR01893 WNT10PROTEIN; PR01894 WNT14PROTEIN; PR01895 WNT16PROTEIN MIM; 604663 Creation date 08-JAN-2003 1. WODARZ, A. AND NUSSE, R. Mechanisms of Wnt signal transduction. ANNU.REV.CELL DEV.BIOL. 14 59-88 (1998). 2. BEJSOVEC, A. Signal transduction: Wnt signalling shows its versatility. CURR.BIOL. 9 R684-R687 (1999). 3. DE FERRARI, G.V. AND INESTROSA, N.C. Wnt signaling function in Alzheimer's disease. BRAIN RES.BRAIN RES.REV. 33 1-12 (2000). 4. SEMENOV, M.V. AND SNYDER, M. Human dishevelled genes constitute a DHR-containing multigene family. GENOMICS 42 302-310 (1997). 5. PEIFER, M. AND POLAKIS, P. Wnt signalling in oncogenesis and embryogenesis - a look outside the nucleus. SCIENCE 287 1606-1609 (2000). 6. MOON, R.T. An introduction to non-canonical Wnt and Frizzled signaling. SEMIN.CELL DEV.BIOL. 13 215 (2002). 7. GAVIN, B.J., MCMAHON, J.A. AND MCMAHON, A.P. Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. GENES DEV. 4 2319-2332 (1990). 8. ITARANTA, P., YANFENG, L., PERASAARI, J., ROEL, G., DESTREE, O. AND VAINIO, S. Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro. GENESIS 32 259-268 (2002). Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) . It is now recognised that Wnt signalling controls many cell fate decisions in a variety of different organisms, including mammals . Wnt signalling has been implicated in tumorigenesis, early mesodermal patterning of the embryo, morphogenesis of the brain and kidneys, regulation of mammary gland proliferation and Alzheimer's disease [3,4]. Wnt-mediated signalling is believed to proceed initially through binding to cell surface receptors of the frizzled family; the signal is subsequently transduced through several cytoplasmic components to B-catenin, which enters the nucleus and activates the transcription of several genes important in development . More recently, however, several non-canonical Wnt signalling pathways have been elucidated that act independently of B-catenin . Members of the Wnt gene family are defined by their sequence similarity to mouse Wnt-1 and Wingless in Drosophila. They encode proteins of ~350-400 residues in length, with orthologues identified in several, mostly vertebrate, species. Very little is known about the structure of Wnts as they are notoriously insoluble; in terms of primary structure, the family is characterised by a signal sequence and an almost invariant pattern of 23-24 conserved cysteines . Fifteen major Wnt gene families have been identified in vertebrates, with multiple subtypes within some classes. Wnt-6 cDNA was isolated from mouse using a PCR-based strategy, where it was found to be expressed in adult tissues, particularly in brain and lung . Furthermore, Wnt-6 is expressed in the ureter bud, where it is believed to activate kidney tubule development . WNT6PROTEIN is a 3-element fingerprint that provides a signature for Wnt-6 proteins. The fingerprint was derived from an initial alignment of 2 sequences: the motifs were drawn from conserved regions spanning the N- terminal half of the alignment, focusing on those sections that characterise Wnt-6 proteins but distinguish them from related Wnt subtypes - motif 1 lies near the N-terminus, preceded by the putative signal peptide; and motifs 2 and 3 reside in regions between conserved cysteine residues. A single iteration on SPTR40_20f was required to reach convergence, no further sequences being identified beyond the starting set. SUMMARY INFORMATION 2 codes involving 3 elements 0 codes involving 2 elements COMPOSITE FINGERPRINT INDEX 3| 2 2 2 2| 0 0 0 --+---------------- | 1 2 3 True positives.. WNT6_HUMAN WNT6_MOUSE PROTEIN TITLES WNT6_HUMAN WNT-6 protein precursor - Homo sapiens (Human). WNT6_MOUSE WNT-6 protein precursor - Mus musculus (Mouse).
SCAN HISTORY SPTR40_20f 1 300 NSINGLE INITIAL MOTIF SETS WNT6PROTEIN1 Length of motif = 11 Motif number = 1 Wnt-6 protein motif I - 1 PCODE ST INT SPLVMDPTSIC WNT6_HUMAN 31 31 SPLVMDPTSIC WNT6_MOUSE 30 30 WNT6PROTEIN2 Length of motif = 12 Motif number = 2 Wnt-6 protein motif II - 1 PCODE ST INT SSHSKAFGRILQ WNT6_HUMAN 88 46 SSHSKAFGRVLQ WNT6_MOUSE 87 46 WNT6PROTEIN3 Length of motif = 26 Motif number = 3 Wnt-6 protein motif III - 1 PCODE ST INT PRPSGLPGTPGPPGPAGSPEGSAAWE WNT6_HUMAN 143 43 PRPSGLLGTPGPPGPTGSPDASAAWE WNT6_MOUSE 142 43 FINAL MOTIF SETS WNT6PROTEIN1 Length of motif = 11 Motif number = 1 Wnt-6 protein motif I - 1 PCODE ST INT SPLVMDPTSIC WNT6_HUMAN 31 31 SPLVMDPTSIC WNT6_MOUSE 30 30 WNT6PROTEIN2 Length of motif = 12 Motif number = 2 Wnt-6 protein motif II - 1 PCODE ST INT SSHSKAFGRILQ WNT6_HUMAN 88 46 SSHSKAFGRVLQ WNT6_MOUSE 87 46 WNT6PROTEIN3 Length of motif = 26 Motif number = 3 Wnt-6 protein motif III - 1 PCODE ST INT PRPSGLPGTPGPPGPAGSPEGSAAWE WNT6_HUMAN 143 43 PRPSGLLGTPGPPGPTGSPDASAAWE WNT6_MOUSE 142 43
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