WORKLIST ENTRIES (1):
WNT16PROTEIN View alignment Wnt-16 protein signature
Type of fingerprint: COMPOUND with 6 elements
Links:
PRINTS; PR01349 WNTPROTEIN
PRINTS; PR01841 WNT1PROTEIN; PR01842 WNT2PROTEIN; PR01843 WNT3PROTEIN
PRINTS; PR01844 WNT4PROTEIN; PR01845 WNT6PROTEIN; PR01891 WNT7PROTEIN
PRINTS; PR01892 WNT8PROTEIN; PR01893 WNT10PROTEIN; PR01894 WNT14PROTEIN
MIM; 606267
Creation date 27-MAY-2003
1. WODARZ, A. AND NUSSE, R.
Mechanisms of Wnt signal transduction.
ANNU.REV.CELL DEV.BIOL. 14 59-88 (1998).
2. BEJSOVEC, A.
Signal transduction: Wnt signalling shows its versatility.
CURR.BIOL. 9 R684-R687 (1999).
3. DE FERRARI, G.V. AND INESTROSA, N.C.
Wnt signaling function in Alzheimer's disease.
BRAIN RES.REV. 33 1-12 (2000).
4. SEMENOV, M.V. AND SNYDER, M.
Human dishevelled genes constitute a DHR-containing multigene family.
GENOMICS 42 302-310 (1997).
5. PEIFER, M. AND POLAKIS, P.
Wnt signalling in oncogenesis and embryogenesis - a look outside the
nucleus.
SCIENCE 287 1606-1609 (2000).
6. MOON, R.T.
An introduction to non-canonical Wnt and Frizzled signaling.
SEMIN.CELL DEV.BIOL. 13 215 (2002).
7. MCWHIRTER, J.R., NEUTEBOOM, S.T., WANCEWICZ, E.V., MONIA, B.P.,
DOWNING, J.R. AND MURRE, C.
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel
WNT gene in pre-B acute lymphoblastoid leukemia.
PROC.NATL.ACAD.SCI.U.S.A. 96 11464-11469 (1999).
Wnt proteins constitute a large family of secreted molecules that are
involved in intercellular signalling during development. The name derives
from the first 2 members of the family to be discovered: int-1 (mouse) and
wingless (Drosophila) [1]. It is now recognised that Wnt signalling controls
many cell fate decisions in a variety of different organisms, including
mammals [2]. Wnt signalling has been implicated in tumorigenesis, early
mesodermal patterning of the embryo, morphogenesis of the brain and kidney,
regulation of mammary gland proliferation, and Alzheimer's disease [3,4].
Wnt-mediated signalling is believed to proceed initially through binding to
cell surface receptors of the frizzled family; the signal is subsequently
transduced through several cytoplasmic components to B-catenin, which enters
the nucleus and activates the transcription of several genes important in
development [5]. More recently, however, several non-canonical Wnt
signalling pathways have been elucidated that act independently of
B-catenin [6]. Members of the Wnt gene family are defined by their sequence
similarity to mouse Wnt-1 and Wingless in Drosophila. They encode proteins
of ~350-400 residues in length, with orthologues identified in several,
mostly vertebrate, species. Very little is known about the structure of
Wnts as they are notoriously insoluble; in terms of primary structure, the
family is characterised by a signal sequence and an almost invariant pattern
of 23-24 conserved cysteines [1]. Fifteen major Wnt gene families have been
identified in vertebrates, with multiple subtypes within some classes.
Expression of Wnt-16 is activated by E2A-Pbx1, a fusion protein resulting
from a t(1;19) translocation that occurs in a large proportion of pediatric
pre-B acute lymphoblastoid leukaemias (pre-B ALL) [7]. The Wnt-16
transcript, normally absent in bone marrow, was found to be highly expressed
in the bone marrow of pre-B ALL patients.
WNT16PROTEIN is a 6-element fingerprint that provides a signature for the
Wnt-16 proteins. The fingerprint was derived from an initial alignment of 2
sequences: the motifs were drawn from conserved regions spanning the full
alignment length, focusing on those sections that characterise Wnt-16
proteins but distinguish them from other Wnt subtypes - motif 1 lies at the
N-terminus, within the putative signal peptide; motif 2 resides within the
N-terminal portion, following the signal peptide; motifs 3-5 are located
between highly conserved cysteines; and motif 6 includes conserved Cys16. A
single iteration on SPTR40_22f was required to reach convergence, no further
sequences being identified beyond the starting set.
SUMMARY INFORMATION
2 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
6| 2 2 2 2 2 2
5| 0 0 0 0 0 0
4| 0 0 0 0 0 0
3| 0 0 0 0 0 0
2| 0 0 0 0 0 0
--+-------------------------------
| 1 2 3 4 5 6
True positives..
WN16_HUMAN WN16_MOUSE
PROTEIN TITLES
WN16_HUMAN WNT-16 protein precursor - Homo sapiens (Human).
WN16_MOUSE WNT-16 protein precursor - Mus musculus (Mouse).
SCAN HISTORY
SPTR40_22f 1 100 NSINGLE
INITIAL MOTIF SETS
WNT16PROTEIN1 Length of motif = 21 Motif number = 1
Wnt-16 protein motif I - 1
PCODE ST INT
AALLGLARLCALWAALLVLFP WN16_HUMAN 4 4
AALLALPSLCALWAAVLSLLP WN16_MOUSE 4 4
WNT16PROTEIN2 Length of motif = 12 Motif number = 2
Wnt-16 protein motif II - 1
PCODE ST INT
IASFGVPEKLGC WN16_HUMAN 36 11
IASFGVPEKLGC WN16_MOUSE 36 11
WNT16PROTEIN3 Length of motif = 14 Motif number = 3
Wnt-16 protein motif III - 1
PCODE ST INT
AAATTAPMGASPLF WN16_HUMAN 96 48
ATTTSTQLATAPLF WN16_MOUSE 95 47
WNT16PROTEIN4 Length of motif = 17 Motif number = 4
Wnt-16 protein motif IV - 1
PCODE ST INT
LDFPIGNTTGKENKVLL WN16_HUMAN 183 73
LDLPIRNTTGKESRVLL WN16_MOUSE 182 73
WNT16PROTEIN5 Length of motif = 14 Motif number = 5
Wnt-16 protein motif V - 1
PCODE ST INT
REKDQRKIPIHKDD WN16_HUMAN 270 70
REKDQRQTPILKDD WN16_MOUSE 269 70
WNT16PROTEIN6 Length of motif = 11 Motif number = 6
Wnt-16 protein motif VI - 1
PCODE ST INT
LLYVNKSPNYC WN16_HUMAN 284 0
LLYVHKSPNYC WN16_MOUSE 283 0
FINAL MOTIF SETS
WNT16PROTEIN1 Length of motif = 21 Motif number = 1
Wnt-16 protein motif I - 1
PCODE ST INT
AALLGLARLCALWAALLVLFP WN16_HUMAN 4 4
AALLALPSLCALWAAVLSLLP WN16_MOUSE 4 4
WNT16PROTEIN2 Length of motif = 12 Motif number = 2
Wnt-16 protein motif II - 1
PCODE ST INT
IASFGVPEKLGC WN16_HUMAN 36 11
IASFGVPEKLGC WN16_MOUSE 36 11
WNT16PROTEIN3 Length of motif = 14 Motif number = 3
Wnt-16 protein motif III - 1
PCODE ST INT
AAATTAPMGASPLF WN16_HUMAN 96 48
ATTTSTQLATAPLF WN16_MOUSE 95 47
WNT16PROTEIN4 Length of motif = 17 Motif number = 4
Wnt-16 protein motif IV - 1
PCODE ST INT
LDFPIGNTTGKENKVLL WN16_HUMAN 183 73
LDLPIRNTTGKESRVLL WN16_MOUSE 182 73
WNT16PROTEIN5 Length of motif = 14 Motif number = 5
Wnt-16 protein motif V - 1
PCODE ST INT
REKDQRKIPIHKDD WN16_HUMAN 270 70
REKDQRQTPILKDD WN16_MOUSE 269 70
WNT16PROTEIN6 Length of motif = 11 Motif number = 6
Wnt-16 protein motif VI - 1
PCODE ST INT
LLYVNKSPNYC WN16_HUMAN 284 0
LLYVHKSPNYC WN16_MOUSE 283 0
User query: Display/Full Code "WNT16PROTEIN"