WORKLIST ENTRIES (1):

TMFOUR View alignment           Transmembrane four family signature
 Type of fingerprint: COMPOUND with 4  elements
Links:
   INTERPRO; IPR000301
   PROSITE; PS00421 TM4
   PFAM; PF00335 transmembrane4

 Creation date 19-JUL-1994; UPDATE 28-JUN-1999

   1. LEVY, S., NGUYEN, Q.V., ANDRIA, M.L. AND TAKAHASHI, S.
   Structure and membrane topology of TAPA-1.
   J.BIOL.CHEM. 266 14597-14602 (1991).

   2. TOMLINSON, M.G., WILLIAMS, A.F. AND WRIGHT, M.D.
   Epitope mapping of anti-rat CD53 monoclonal antibodies. Implications for
   the membrane orientation of the Transmembrane 4 Superfamily.
   EUR.J.IMMUNOL. 23 136-140 (1993).

   A number of eukaryotic cell surface antigens have been shown to be related
   [1], including mammalian leukocyte antigen CD37, mammalian lysosomal 
   membrane protein CD63, human tumour-associated antigen CD-029, and several
   others. These proteins are all type II membrane proteins: they contain an
   N-terminal transmembrane (TM) domain, which acts both as a signal sequence
   and a membrane anchor, and 3 additional TM regions (hence the name 'TM4').
   The sequences contain a number of conserved cysteine residues. 
   
   TMFOUR is a 4-element fingerprint that provides a signature for the
   TM4 proteins. The fingerprint was derived from an initial alignment of 8
   sequences: the motifs were drawn largely from the TM domains, motifs 2 and
   3 spanning the region encoded by PROSITE pattern TM4 (PS00421), which 
   encompasses the intervening loop. Two iterations on OWL23.2 were required
   to reach convergence, at which point a true set comprising 20 sequences was
   identified. A single partial match (B35826) was also found, a fragment
   lacking part of TM domain 4.
  
   An update on SPTR37_9f identified a true set of 47 sequences, and 6
   partial matches.

  SUMMARY INFORMATION
     47 codes involving  4 elements
      3 codes involving  3 elements
      3 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    4|  47   47   47   47  
    3|   2    3    2    2  
    2|   2    3    0    1  
   --+---------------------
     |   1    2    3    4  

True positives..
 CD9_FELCA      CD9_CERAE      CD9_HUMAN      CD9_BOVIN      
 CD9_MOUSE      CD9_RAT        CD81_HUMAN     CD81_MOUSE     
 Q62745         CO02_HUMAN     CD82_HUMAN     O55158         
 O60636         O70352         CD82_MOUSE     O89118         
 C151_HUMAN     CD53_RAT       C151_MOUSE     CD53_MOUSE     
 CD53_HUMAN     O75954         NAG2_HUMAN     O88429         
 A15_MOUSE      A15_HUMAN      O60635         O60745         
 CD63_HUMAN     CD63_RAT       CD63_RABIT     CD63_MOUSE     
 O70401         O43657         CD37_MOUSE     CD37_RAT       
 O60746         CD37_HUMAN     IM23_SCHMA     IM23_SCHHA     
 Q19983         IM23_SCHJA     Q22495         O60637         
 Q18177         SAS_HUMAN      O76137         
Subfamily:  Codes involving 3 elements
 Subfamily True positives..
 O60628         Q17526         YL11_CAEEL     
Subfamily:  Codes involving 2 elements
 Subfamily True positives..
 O46101         O02138         O44582         


  PROTEIN TITLES
   CD9_FELCA        CD9 ANTIGEN - FELIS SILVESTRIS CATUS (CAT).
   CD9_CERAE        CD9 ANTIGEN (27 KD DIPHTHERIA TOXIN RECEPTOR-ASSOCIATED PROT
   CD9_HUMAN        CD9 ANTIGEN (P24) (LEUKOCYTE ANTIGEN MIC3) (MOTILITY-RELATED
   CD9_BOVIN        CD9 ANTIGEN - BOS TAURUS (BOVINE).
   CD9_MOUSE        CD9 ANTIGEN - MUS MUSCULUS (MOUSE).
   CD9_RAT          CD9 ANTIGEN - RATTUS NORVEGICUS (RAT).
   CD81_HUMAN       CD81 ANTIGEN (26 KD CELL SURFACE PROTEIN TAPA-1) - HOMO SAPI
   CD81_MOUSE       CD81 ANTIGEN (26 KD CELL SURFACE PROTEIN TAPA-1) - MUS MUSCU
   Q62745           TARGET OF THE ANTIPROLIFERATIVE ANTIBODY - RATTUS NORVEGICUS
   CO02_HUMAN       TUMOR-ASSOCIATED ANTIGEN CO-029 - HOMO SAPIENS (HUMAN).
   CD82_HUMAN       CD82 ANTIGEN (INDUCIBLE MEMBRANE PROTEIN R2) (C33 ANTIGEN) (
   O55158           D6.1A PROTEIN - RATTUS NORVEGICUS (RAT).
   O60636           TSPAN-2 - HOMO SAPIENS (HUMAN).
   O70352           METASTASIS SUPPRESSOR HOMOLOG - RATTUS NORVEGICUS (RAT).
   CD82_MOUSE       CD82 ANTIGEN (INDUCIBLE MEMBRANE PROTEIN R2) (C33 ANTIGEN) (
   O89118           PLATELET ENDOTHELIAL TETRASPAN ANTIGEN-3 - MUS MUSCULUS (MOU
   C151_HUMAN       PLATELET-ENDOTHELIAL TETRASPAN ANTIGEN 3 (PETA-3) (GP27) (ME
   CD53_RAT         LEUKOCYTE SURFACE ANTIGEN CD53 (CELL SURFACE GLYCOPROTEIN CD
   C151_MOUSE       PLATELET-ENDOTHELIAL TETRASPAN ANTIGEN 3 (PETA-3) (GP27) (ME
   CD53_MOUSE       LEUKOCYTE SURFACE ANTIGEN CD53 (CELL SURFACE GLYCOPROTEIN CD
   CD53_HUMAN       LEUKOCYTE SURFACE ANTIGEN CD53 (CELL SURFACE GLYCOPROTEIN CD
   O75954           TETRASPAN NET-5 - HOMO SAPIENS (HUMAN).
   NAG2_HUMAN       NOVEL ANTIGEN 2 (NAG-2) (TSPAN-4) - HOMO SAPIENS (HUMAN).
   O88429           CELL SURFACE GLYCOPROTEIN A15 - MUS MUSCULUS (MOUSE).
   A15_MOUSE        CELL SURFACE GLYCOPROTEIN A15 (PE31) (TALLA HOMOLOG) - MUS M
   A15_HUMAN        CELL SURFACE GLYCOPROTEIN A15 (T-CELL ACUTE LYMPHOBLASTIC LE
   O60635           TSPAN-1 - HOMO SAPIENS (HUMAN).
   O60745           TETRASPAN NET-1 - HOMO SAPIENS (HUMAN).
   CD63_HUMAN       CD63 ANTIGEN (MELANOMA-ASSOCIATED ANTIGEN ME491) (LYSOSOME-A
   CD63_RAT         CD63 ANTIGEN (AD1 ANTIGEN) - RATTUS NORVEGICUS (RAT).
   CD63_RABIT       CD63 ANTIGEN - ORYCTOLAGUS CUNICULUS (RABBIT).
   CD63_MOUSE       CD63 ANTIGEN - MUS MUSCULUS (MOUSE).
   O70401           TETRASPANIN TSPAN-6 - MUS MUSCULUS (MOUSE).
   O43657           T245 PROTEIN - HOMO SAPIENS (HUMAN).
   CD37_MOUSE       LEUKOCYTE ANTIGEN CD37 - MUS MUSCULUS (MOUSE).
   CD37_RAT         LEUKOCYTE ANTIGEN CD37 - RATTUS NORVEGICUS (RAT).
   O60746           TETRASPAN NET-4 - HOMO SAPIENS (HUMAN).
   CD37_HUMAN       LEUKOCYTE ANTIGEN CD37 - HOMO SAPIENS (HUMAN).
   IM23_SCHMA       23 KD INTEGRAL MEMBRANE PROTEIN (SM23) - SCHISTOSOMA MANSONI
   IM23_SCHHA       23 KD INTEGRAL MEMBRANE PROTEIN (SH23) - SCHISTOSOMA HAEMATO
   Q19983           F33C8.3 PROTEIN - CAENORHABDITIS ELEGANS.
   IM23_SCHJA       23 KD INTEGRAL MEMBRANE PROTEIN (SJ23) - SCHISTOSOMA JAPONIC
   Q22495           T14G10.6 PROTEIN - CAENORHABDITIS ELEGANS.
   O60637           TSPAN-3 - HOMO SAPIENS (HUMAN).
   Q18177           SIMILAR TO SMALL TYPE-II MEMBRANE ANTIGEN. NCBI GI: 1086714 
   SAS_HUMAN        SARCOMA AMPLIFIED SEQUENCE - HOMO SAPIENS (HUMAN).
   O76137           TM4SF PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
 
   O60628           TETRASPANIN TSPAN-5 - HOMO SAPIENS (HUMAN).
   Q17526           SIMILAR TO HUMAN INDUCIBLE MEMBRANE PROTEIN R2 - CAENORHABDI
   YL11_CAEEL       HYPOTHETICAL 35.3 KD PROTEIN C02F12.1 IN CHROMOSOME X - CAEN
 
   O46101           EG:8D8.7 PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
   O02138           SIMILAR TO THE FAMILY OF SMALL TYPE-III MEMBRANE ANTIGENS - 
   O44582           F39C12.3 PROTEIN - CAENORHABDITIS ELEGANS.

SCAN HISTORY OWL23_2 2 100 NSINGLE OWL28_0 1 100 NSINGLE SPTR37_9f 3 100 NSINGLE INITIAL MOTIF SETS TMFOUR1 Length of motif = 24 Motif number = 1 Transmembrane four protein motif I - 1 PCODE ST INT YLLFGFNFIFWLAGIAVLAIGLWL CD9_CERAE 11 11 YLLFGFNFIFWLAGIAVLSVGLWL CD9_BOVIN 11 11 YLLFVFNFVFWLAGGVILGVALWL TAPA_HUMAN 12 12 YFLFLFNLIFFILGAVILGFGVWI R2_HUMAN 11 11 YVLFFFNFLFWVCGCCILGFGIHL CD53_RAT 10 10 FLLYVLLLAFCACAVGLIAIGVAV AD1_RAT 11 11 FLLYVLLLAFCACAVGLIAVGVGA CD63_HUMAN 11 11 TMFOUR2 Length of motif = 27 Motif number = 2 Transmembrane four protein motif II - 1 PCODE ST INT FYTGVYILIGAGALMMLVGFLGCCGAV CD9_CERAE 55 20 FYTGVYILIGAGALMMLVGFLGCCGAV CD9_BOVIN 53 18 FYVGIYILIAVGAVMMFVGFLGCYGAI TAPA_HUMAN 58 22 LRMGAYVFIGVGAVTMLMGFLGCIGAV R2_HUMAN 52 17 FLTLGNVLVIVGSIIMVVAFLGCMGSI CD53_RAT 48 14 GSLLPVVIIAVGAFLFLVAFVGCCGAC AD1_RAT 49 14 GSLLPVVIIAVGVFLFLVAFVGCCGAC CD63_HUMAN 49 14 TMFOUR3 Length of motif = 29 Motif number = 3 Transmembrane four protein motif III - 1 PCODE ST INT QESQCMLGLFFGFLLVIFAIEIAAAIWGY CD9_CERAE 82 0 QESQCMLGLFFSFLLVIFAIEVAAAIWGY CD9_BOVIN 80 0 QESQCLLGTFFTCLVILFACEVAAGIWGF TAPA_HUMAN 85 0 NEVRCLLGLYFAFLLLILIAQVTAGALFY R2_HUMAN 79 0 KENKCLLMSFFVLLLLILLAEVTLAILLF CD53_RAT 75 0 KENYCLMITFAIFLSLIMLVEVAVAIAGY AD1_RAT 76 0 KENYCLMITFAIFLSLIMLVEVAAAIAGY CD63_HUMAN 76 0 TMFOUR4 Length of motif = 27 Motif number = 4 Transmembrane four protein motif IV - 1 PCODE ST INT IIGAVGIGIAVVMIFGMIFSMILCCAI CD9_CERAE 194 83 IIGAVGIGIAVVMIFGMVFSMILCCAI CD9_BOVIN 192 83 LIGIAAIVVAVIMIFEMILSMVLCCGI TAPA_HUMAN 204 90 IILGVGVGVAIIELLGMVLSICLCRHV R2_HUMAN 230 122 YIGIVTICVCVIQVLGMSFALTLNCQI CD53_RAT 183 79 LVAGAALGIAFVEVLGIIFSCCLVKSI AD1_RAT 204 99 VVAAAALGIAFVEVLGIVFACCLVKSI CD63_HUMAN 204 99 FINAL MOTIF SETS TMFOUR1 Length of motif = 24 Motif number = 1 Transmembrane four protein motif I - 3 PCODE ST INT YLLFGFNFIFWLAGIAVLAVGLWL CD9_FELCA 11 11 YLLFGFNFIFWLAGIAVLAIGLWL CD9_CERAE 11 11 YLLFGFNFIFWLAGIAVLAIGLWL CD9_HUMAN 11 11 YLLFGFNFIFWLAGIAVLSVGLWL CD9_BOVIN 11 11 YLLFGFNFIFWLAGIAVLAIGLWL CD9_MOUSE 11 11 YLLFGFNFIFWLAGIAVLAIGLWL CD9_RAT 11 11 YLLFVFNFVFWLAGGVILGVALWL CD81_HUMAN 12 12 YLLFVFNFVFWLAGGVILGVALWL CD81_MOUSE 12 12 YLLFVFNFVFWLAGGVILGVALWL Q62745 12 12 YSMFTFNFLFWLCGILILALAIWV CO02_HUMAN 10 10 YFLFLFNLIFFILGAVILGFGVWI CD82_HUMAN 11 11 YSMFFFNFLFWVCGTLILGLAIWL O55158 10 10 YLLLGFNLLFWLAGSAVIAFGLWF O60636 13 13 YFLFLFNLLFFILGAVILGFGVWI O70352 11 11 YFLFLFNLLFFILGAVILGFGVWI CD82_MOUSE 11 11 YLLFTYNCCFWLAGLAVMAVGIWT O89118 18 18 YLLFTYNCCFWLAGLAVMAVGIWT C151_HUMAN 18 18 YVLFFFNFLFWVCGCCILGFGIHL CD53_RAT 10 10 YLLFTYNCCFWLAGLAVMAVGIWT C151_MOUSE 18 18 YVLFIFNLLFWVCGCCILGFGIYF CD53_MOUSE 10 10 YVLFFFNLLFWICGCCILGFGIYL CD53_HUMAN 11 11 YMMFLFNLIFWLCGCGLLGVGIWL O75954 11 11 YLMFAFNLLFWLGGCGVLGVGIWL NAG2_HUMAN 11 11 TLLIIYSFVFWITGVILLAVGVWG O88429 12 12 TLLIIYSFVFWITGVILLAVGVWG A15_MOUSE 12 12 TLLIIYSFVFWITGVILLAVGVWG A15_HUMAN 12 12 TMMILFNLLIFLCGAALLAVGIWV O60635 9 9 TMMILFNLLIFLCGAALLAVGIWV O60745 9 9 FLLYVLLLAFCACAVGLIAVGVGA CD63_HUMAN 11 11 FLLYVLLLAFCACAVGLIAIGVAV CD63_RAT 11 11 FLLYVLLLAFCACAVGLIAVGVGA CD63_RABIT 11 11 FLLYVLLLAFCACAVGLIAIGVAV CD63_MOUSE 11 11 SVLLIYTFIFWITGVILLAVGIWG O70401 19 19 SVLLIYTFIFWITGVILLAVGIWG O43657 19 19 YFLFVFNLFFFVLGGLIFCFGTWI CD37_MOUSE 13 13 YFLFVFNLFFFVLGGLIFCFGTWI CD37_RAT 13 13 YFIFGFNVIFWFLGITFLGIGLWA O60746 17 17 YFLFVFNLFFFVLGSLIFCFGIWI CD37_HUMAN 13 13 SCVFVLNIICLLCSLVLIGAGAYV IM23_SCHMA 13 13 SCVFVLNIICLLCSLVLIGAGAYV IM23_SCHHA 13 13 IVTFLFNFAFWLSGVVVFGLGIWL Q19983 10 10 SCVFILNIICLLCSLVLIGAGAYV IM23_SCHJA 13 13 YSVFSFNVIFFLLGFGLLLFGVWA Q22495 40 40 TVLVFLNLIFWGAAGILCYVGAYV O60637 11 11 LLFFVINFFICIFGALICGFSLWA Q18177 10 10 NALCALNVVYMLVSLLLIGVAAWG SAS_HUMAN 11 11 YLVYSYVVLLALTGAAQIFLGTSL O76137 12 12 TMFOUR2 Length of motif = 27 Motif number = 2 Transmembrane four protein motif II - 3 PCODE ST INT FYTGVYILIGAGALMMLVGFLGCCGAV CD9_FELCA 53 18 FYTGVYILIGAGALMMLVGFLGCCGAV CD9_CERAE 55 20 FYTGVYILIGAGALMMLVGFLGCCGAV CD9_HUMAN 55 20 FYTGVYILIGAGALMMLVGFLGCCGAV CD9_BOVIN 53 18 FYTGVYILIGAGALMMLVGFLGCCGAV CD9_MOUSE 53 18 FYTGVYILIGAGALMMLVGFLGCCGAV CD9_RAT 53 18 FYVGIYILIAVGAVMMFVGFLGCYGAI CD81_HUMAN 58 22 FYVGIYILIAVGAVMMFVGFLGCYGAI CD81_MOUSE 58 22 FYVGIYILIAVGAVMMFVGFLGCYGAI Q62745 58 22 SYVAVDILIAVGAIIMILGFLGCCGAI CO02_HUMAN 52 18 LRMGAYVFIGVGAVTMLMGFLGCIGAV CD82_HUMAN 52 17 PFIAVNILIAVGSIIMVLGFLGCCGAV O55158 52 18 FYVGLYVLVGAGALMMAVGFFGCCGPC O60636 55 18 LQVGAYVFIGVGAITMLMGFLGCIGAV O70352 52 17 LQVGAYVFIGVGAITIVMGFLGCIGAV CD82_MOUSE 52 17 YLATAYILVVAGVVVMVTGVLGCCATF O89118 57 15 YLATAYILVVAGTVVMVTGVLGCCATF C151_HUMAN 57 15 FLTLGNVLVIVGSIIMVVAFLGCMGSI CD53_RAT 48 14 YLATAYILVVAGVVVMVTGVLGCCATF C151_MOUSE 57 15 FLTLGNILVIVGSIIMVVAFLGCMGSI CD53_MOUSE 48 14 SLTLGNVFVIVGSIIMVVAFLGCMGSI CD53_HUMAN 49 14 SLSAANLVIAIGTIVMVTGFLGCLGAI O75954 50 15 SLSAANLLIITGAFVMAIGFVGCLGAI NAG2_HUMAN 50 15 STNAPYVLIGTGTTIVVFGLFGCFATC O88429 50 14 STNAPYVLIGTGTTIVVFGLFGCFATC A15_MOUSE 50 14 STNAPYVLIGTGTTIVVFGLFGCFATC A15_HUMAN 50 14 FVNVGYFLIAAGVVVFALGFLGCYGAK O60635 53 20 FVNVGYFLIAAGVVVFALGFLGCYGAK O60745 53 20 GSLLPVVIIAVGVFLFLVAFVGCCGAC CD63_HUMAN 49 14 GSLLPVVIIAVGAFLFLVAFVGCCGAC CD63_RAT 49 14 GSLLPVVIIAVGAFLFLVAFVGCCGTC CD63_RABIT 49 14 GSLLPVVIIAVGAFLFLVAFVGCCGAC CD63_MOUSE 49 14 ATNVPFVLIGTGTVIILLGTFGCFATC O70401 57 14 ATNVPFVLIATGTVIILLGTFGCFATC O43657 57 14 LQTWSKVLAVSGVLTMALALLGCVGAL CD37_MOUSE 54 17 LQTWSKVLSVSGVLTMALALLGCVGAL CD37_RAT 54 17 GFDPVWLFLVVGGVMFILGFAGCIGAL O60746 58 17 LQIWSKVLAISGIFTMGIALLGCVGAL CD37_HUMAN 54 17 WQAAPIAIIVVGVIILIVSFLGCCGAI IM23_SCHMA 51 14 WQAAPIAIIVVGVIILIVSFLGCCGAI IM23_SCHHA 51 14 FRYVGWFLVGAGAIIILVGYFGCIGAW Q19983 53 19 WQAAPIAIIVVGVVILIVSFLGCCGAI IM23_SCHJA 51 14 YLDPTWPLLIVGFLTFIIGFSGCVGSL Q22495 81 17 TLIPAVVIIAVGALLFIIGLIGCCATI O60637 50 15 YQASLWILVAVGALLFLVGFFGCCGAG Q18177 64 30 SIHIIGGVIAVGVFLLLIAVAGLVGAV SAS_HUMAN 42 7 LWAPAAILLCLGPVTFILCWMGCQATN O76137 50 14 TMFOUR3 Length of motif = 29 Motif number = 3 Transmembrane four protein motif III - 3 PCODE ST INT QESQCMLGLFFGFLLVIFAIEIAAAIWGY CD9_FELCA 80 0 QESQCMLGLFFGFLLVIFAIEIAAAIWGY CD9_CERAE 82 0 QESQCMLGLFFGFLLVIFAIEIAAAIWGY CD9_HUMAN 82 0 QESQCMLGLFFSFLLVIFAIEVAAAIWGY CD9_BOVIN 80 0 QESQCMLGLFFGFLLVIFAIEIAAAVWGY CD9_MOUSE 80 0 QESQCMLGLFFGFLLVIFAIEIAAAVWGY CD9_RAT 80 0 QESQCLLGTFFTCLVILFACEVAAGIWGF CD81_HUMAN 85 0 QESQCLLGTFFTCLVILFACEVAAGIWGF CD81_MOUSE 85 0 QESQCLLGTFFTCLVILFACEVAAGIWGF Q62745 85 0 KESRCMLLLFFIGLLLILLLQVATGILGA CO02_HUMAN 79 0 NEVRCLLGLYFAFLLLILIAQVTAGALFY CD82_HUMAN 79 0 KESRCMLLLFFIGLLLILLLQVAAGILGA O55158 79 0 WESQCVLGSFFTCLLVIFAAEVTTGVFAF O60636 82 0 NEVRCLLGLYFVFLLLILIAQVTVEVLFY O70352 79 0 NEVRCLLGLYFVFLLLILIAQVTVGVLFY CD82_MOUSE 79 0 KERRNLLRLYFILLLIIFLLEIIAGILAY O89118 84 0 KERRNLLRLYFILLLIIFLLEIIAGILAY C151_HUMAN 84 0 KENKCLLMSFFVLLLLILLAEVTLAILLF CD53_RAT 75 0 KERRNLLRLYFILLLIIFLLEIIAGILAY C151_MOUSE 84 0 KENKCLLMSFFVLLLIILLAEVTIAILLF CD53_MOUSE 75 0 KENKCLLMSFFILLLIILLAEVTLAILLF CD53_HUMAN 76 0 KENKCLLLSFFIVLLVILLAELILLILFF O75954 77 0 KENKCLLLTFFLLLLLVFLLEATIAILFF NAG2_HUMAN 77 0 RGSPWMLKLYAMFLSLVFLAELVAGISGF O88429 77 0 RGSPWMLKLYAMFLSLVFLAELVAGISGF A15_MOUSE 77 0 RGSPWMLKLYAMFLSLVFLAELVAGISGF A15_HUMAN 77 0 TESKCALVTFFFILLLIFIAEVAAAVVAL O60635 80 0 TESKCALVTFFFILLLIFIAEVAAAVVAL O60745 80 0 KENYCLMITFAIFLSLIMLVEVAAAIAGY CD63_HUMAN 76 0 KENYCLMITFAIFLSLIMLVEVAVAIAGY CD63_RAT 76 0 KENYCLMITFAIFLSLIMLVEVAAAIAGY CD63_RABIT 76 0 KENYCLMITFAIFLSLIMLVEVAVAIAGY CD63_MOUSE 76 0 RTSAWMLKLYAMFLTLIFLVELVAAIVGF O70401 84 0 RASAWMLKLYAMFLTLVFLVELVAAIVGF O43657 84 0 KELRCLLGLYFGMLLLLFATQITLGILIS CD37_MOUSE 81 0 KELRCLLGLYFGMLLLLFATQITLGILIS CD37_RAT 81 0 RENTFLLKFFSVFLGIIFFLELTAGVLAF O60746 85 0 KELRCLLGLYFGMLLLLFATQITLGILIS CD37_HUMAN 81 0 KENVCMLYMYAFFLVVLLIAELAAAIVAV IM23_SCHMA 78 0 KENVCMLYMYAFFLIILLIAELAAAIVAV IM23_SCHHA 78 0 KMNQCALAFFCCILILAFFLELAAAVTLF Q19983 80 0 KENVCMLYMYAFFLIVLLIAELVAAIVAV IM23_SCHJA 78 0 RENTSFLTFYSTLLGLLLIAEFSAGVFAY Q22495 108 0 RESRCGLATFVIILLLVFVTEVVVVVLGY O60637 77 0 CESPVLLGLFIFIIVILTAVELGATVFAM Q18177 91 0 NHHQVLLFFYMIILGLVFIFQFVISCSCL SAS_HUMAN 69 0 QRKRCLLGMFAALLVACICVQFIICGWSL O76137 77 0 TMFOUR4 Length of motif = 27 Motif number = 4 Transmembrane four protein motif IV - 3 PCODE ST INT IIGAVGIGIAVVMIFGMIFSMILCCAI CD9_FELCA 192 83 IIGAVGIGIAVVMIFGMIFSMILCCAI CD9_CERAE 194 83 IIGAVGIGIAVVMIFGMIFSMILCCAI CD9_HUMAN 194 83 IIGAVGIGIAVVMIFGMVFSMILCCAI CD9_BOVIN 192 83 IIGAVGIGIAVVMIFGMIFSMILCCAI CD9_MOUSE 192 83 IIGAVGIGIAVVMIFGMIFSMILCCAI CD9_RAT 192 83 LIGIAAIVVAVIMIFEMILSMVLCCGI CD81_HUMAN 204 90 LIGIAAIVVAVIMIFEMILSMVLCCGI CD81_MOUSE 204 90 LIGIAAIVVAVIMIFEMILSMVLCCGI Q62745 204 90 IVIGISFGLAVIEILGLVFSMVLYCQI CO02_HUMAN 208 100 IILGVGVGVAIIELLGMVLSICLCRHV CD82_HUMAN 230 122 IVIGIAFGLAVIEILGLVFSMVLYCQI O55158 206 98 LIGIVGIGIAGLTIFGMIFSMVLCCAI O60636 189 78 ILLGVCAGVAVIELLGLFLSICLCRYI O70352 229 121 ILLGVCAGVAVIELLGLFLSICLCRYI CD82_MOUSE 229 121 VIGAVGIGIACVQVFGMIFTCCLYRSL O89118 222 109 VIGAVGIGIACVQVFGMIFTCCLYRSL C151_HUMAN 222 109 YIGIVTICVCVIQVLGMSFALTLNCQI CD53_RAT 183 79 VIGAVGIGIACVQVFSMIFTCCLYRSL C151_MOUSE 222 109 YIGIITICVCVIQVLGMSFALTLNCQI CD53_MOUSE 183 79 YIGIITICVCVIEVLGMSFALTLNCQI CD53_HUMAN 184 79 VLGTVGMCILIMQILGMAFSMTLFQHI O75954 204 98 AVGIFGLCTALVQILGLTFAMTMYCQV NAG2_HUMAN 204 98 IIAGVAFGIAFSQLIGMLLACCLSRFI O88429 210 104 IIAGVAFGIAFSQLIGMLLACCLSRFI A15_MOUSE 210 104 IIAGVAFGIAFSQLIGMLLACCLSRFI A15_HUMAN 210 104 TVGGVAAGIGGLELAAMIVSMYLYCNL O60635 214 105 TVGGVAAGIGGLELAAMIVSMYLYCNL O60745 214 105 VVAAAALGIAFVEVLGIVFACCLVKSI CD63_HUMAN 204 99 LVAGAALGIAFVEVLGIIFSCCLVKSI CD63_RAT 204 99 VVAAAALGIAFVEVLGIVFACCLVKSI CD63_RABIT 204 99 LVAAAALGIAFVEVLGIIFSCCLVKSI CD63_MOUSE 204 99 VVAGISFGVACFQLIGIFLAYCLSRAI O70401 211 98 VVAGISFGVACFQLIGIFLAYCLSRAI O43657 211 98 SIVGICLGVGLLELGFMTLSIFLCRNL CD37_MOUSE 244 134 SIVGICLGVGLLELGFMTLSIFLCRNL CD37_RAT 244 134 IVAGIFIGIALLQIFGICLAQNLVSDI O60746 235 121 SIVGICLGVGLLELGFMTLSIFLCRNL CD37_HUMAN 244 134 IVACVAFGVCFFQLLSIVIACCLGRQI IM23_SCHMA 186 79 IVACVAFGVCFFQLLSIVIACCLGRQI IM23_SCHHA 186 79 LIVGVCVVLCIVQLLGIVLSMTLCCCK Q19983 251 142 IVACVAFGVCFFQLLSIVIACCLGQRI IM23_SCHJA 186 79 LVAVSMVIIAIIQVLGICFAQNLKSDI Q22495 271 134 HVIWAALAFAAIQLLGMLCACIVLCRR O60637 211 105 SIVVVAFLLLAIELFAILFSCILCRSS Q18177 197 77 ILGGVGLFFSFTEILGVWLAMRFRNQK SAS_HUMAN 174 76 ITAFGAAIIAIFQSLGIFCAVHLTILF O76137 202 96

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