WORKLIST ENTRIES (1):

RABAPTIN View alignment         Rabaptin signature
 Type of fingerprint: COMPOUND with 12 elements
Links:
   

 Creation date 30-OCT-2000

   1. NISHIMUNE, H., UYEDA, A., NOGAWA, M., FUJIMORI, K. AND TAGUCHI, T.
   Neurocrescin: a novel neurite-outgrowth factor secreted by muscle after
   denervation. 
   NEUROREPORT 8 3649-3654 (1997). 

   2. STENMARK, H., VITALE, G., ULLRICH, O. AND ZERIAL, M.
   Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic
   membrane fusion.
   CELL 83 423-432 (1995). 

   Regeneration of injured axons at neuromuscular junctions has been assumed
   to be regulated by extra-cellular factors that promote neurite outgrowth.
   A novel neurite outgrowth factor from chick denervated skeletal muscle has 
   been cloned and characterised. The protein, termed neurocrescin (rabaptin),
   has been shown to be secreted in an activity-dependent fashion [1].
  
   Rabaptin is a 100kDa coiled-coil protein that interacts with the GTP form
   of the small GTPase Rab5, a potent regulator of endocytic transport [2]. It
   is mainly cytosolic, but a fraction co-localises with Rab5 to early 
   endosomes [2]. Rab5 recruits rabaptin-5 to purified early endosomes in a
   GTP-dependent manner, demonstrating functional similarities with other
   members of the Ras superfamily [2]. Immunodepletion of rabaptin-5 from 
   cytosol strongly inhibits Rab5-dependent early endosome fusion. Thus, 
   rabaptin-5 is a Rab effector required for membrane docking and fusion [2].
  
   RABAPTIN is a 12-element fingerprint that provides a signature for
   rabaptins. The fingerprint was derived from an initial alignment of 6
   sequences: the motifs were drawn largely from hydrophobic segments spanning
   virtually the full alignment length. A single iteration on SPTR39_14f was 
   required to reach convergence, no further sequences being identified beyond
   the starting set. A single partial match was found, Q62835, a fos-related 
   antigen from Rattus norvegicus that matches motifs 2, 3, 8 and 11.

  SUMMARY INFORMATION
      6 codes involving 12 elements
      0 codes involving 11 elements
      0 codes involving 10 elements
      0 codes involving  9 elements
      0 codes involving  8 elements
      0 codes involving  7 elements
      0 codes involving  6 elements
      0 codes involving  5 elements
      1 codes involving  4 elements
      0 codes involving  3 elements
      0 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
   12|   6    6    6    6    6    6    6    6    6    6    6    6  
   11|   0    0    0    0    0    0    0    0    0    0    0    0  
   10|   0    0    0    0    0    0    0    0    0    0    0    0  
    9|   0    0    0    0    0    0    0    0    0    0    0    0  
    8|   0    0    0    0    0    0    0    0    0    0    0    0  
    7|   0    0    0    0    0    0    0    0    0    0    0    0  
    6|   0    0    0    0    0    0    0    0    0    0    0    0  
    5|   0    0    0    0    0    0    0    0    0    0    0    0  
    4|   0    1    1    0    0    0    0    1    0    0    1    0  
    3|   0    0    0    0    0    0    0    0    0    0    0    0  
    2|   0    0    0    0    0    0    0    0    0    0    0    0  
   --+-------------------------------------------------------------
     |   1    2    3    4    5    6    7    8    9   10   11   12  

True positives..
 O35550         O35551         Q15276         O95369         
 P70609         O42351         
Subfamily:  Codes involving 4 elements
 Subfamily True positives..
 Q62835         


  PROTEIN TITLES
   O35550           RAT RABAPTIN-5 - Rattus norvegicus (Rat).
   O35551           MOUSE RABAPTIN-5 (NEUROCRESCIN) - Mus musculus (Mouse).
   Q15276           RABAPTIN-5 - Homo sapiens (Human).
   O95369           RABAPTIN-4 - Homo sapiens (Human).
   P70609           RABAPTIN - Rattus norvegicus (Rat).
   O42351           CHICKEN RABAPTIN-5 (NEUROCRESCIN) - Gallus gallus (Chicken).
 
   Q62835           FOS-RELATED ANTIGEN - Rattus norvegicus (Rat).

SCAN HISTORY SPTR39_14f 1 50 NSINGLE INITIAL MOTIF SETS RABAPTIN1 Length of motif = 20 Motif number = 1 Rabaptin motif I - 1 PCODE ST INT DVSLQQRVAELEKINAEFLR O95369 11 11 DVSLQQRVAELEKINAEFLR Q15276 11 11 DVALLQRVAELEKVNAEFLR O42351 11 11 DVSLQQRVAELEKINAEFLR O35551 11 11 DVSLQQRVAELEKINAEFLR P70609 11 11 DVSLQQRVAELEKINAEFLR O35550 11 11 RABAPTIN2 Length of motif = 18 Motif number = 2 Rabaptin motif II - 1 PCODE ST INT LWEAQAEMENIKAIATVS O95369 78 47 LWEAQAEMENIKAIATVS Q15276 78 47 LMEAHAEMENIKAIATVS O42351 78 47 LWEAQAEMENIKAIATVS O35551 78 47 LSEAQADMENIKAIATVS P70609 78 47 LWEAQAEMENIKAIATVS O35550 78 47 RABAPTIN3 Length of motif = 19 Motif number = 3 Rabaptin motif III - 1 PCODE ST INT AEKLRSVVMPMEKEIAALK O95369 181 85 AEKLRSVVMPMEKEIAALK Q15276 181 85 AEKLRSVVMPMEKEIAALK O42351 181 85 AEKLRSVVMPMEKEIAALK O35551 181 85 AEKLRSVVMPMEKEIAALK P70609 181 85 AEKLRSVVMPMEKEIAALK O35550 181 85 RABAPTIN4 Length of motif = 22 Motif number = 4 Rabaptin motif IV - 1 PCODE ST INT CRTDLEMYVAVLNTQKSVLQED O95369 230 30 CRTDLEMYVAVLNTQKSVLQED Q15276 230 30 CRTDLEMYVAVLNTQKSVLQED O42351 230 30 CRTDLEMYVAVLNTQKSVLQED O35551 230 30 CRTDLEMYVAVLNTQKSVLQED P70609 230 30 CRTDLEMYVAVLNTQKSVLQED O35550 230 30 RABAPTIN5 Length of motif = 18 Motif number = 5 Rabaptin motif V - 1 PCODE ST INT HLDSTRGSVHSLDAGLLL O95369 367 115 HLDSTRGSVHSLDAGLLL Q15276 367 115 HLNSTHSSVHSLDADLLL O42351 365 113 HLDSTHGSVHSLDADLML O35551 367 115 HLDSTHGSVHSLDADLLL P70609 367 115 HLDSTHGSVHSLDADLLL O35550 367 115 RABAPTIN6 Length of motif = 19 Motif number = 6 Rabaptin motif VI - 1 PCODE ST INT LQSKALGYNYKAKSAGNLD O95369 417 32 LQSKALGYNYKAKSAGNLD Q15276 417 32 LQSKALGYNNKAKSAGNLD O42351 415 32 LQSKALGYNYKAKSAGNLD O35551 417 32 LQSKALGYNYKAKSAGNLD P70609 417 32 LQSKALGYNYKAKSAGNLD O35550 417 32 RABAPTIN7 Length of motif = 21 Motif number = 7 Rabaptin motif VII - 1 PCODE ST INT SENFDTASLGSLQMPSGFMLT O95369 449 13 SENFDTASLGSLQMPSGFMLT Q15276 449 13 SENYDTASLGSLQMPSGFMLT O42351 447 13 SENFDTVSLGSLQMPSGFMLT O35551 449 13 SENFDTVSLESLQMPSGFMLT P70609 449 13 SENFDTVSLGSLQMPSGFMLT O35550 449 13 RABAPTIN8 Length of motif = 21 Motif number = 8 Rabaptin motif VIII - 1 PCODE ST INT RAIKAMTPEQEETASLLSSVT O95369 474 4 RAIKAMTPEQEETASLLSSVT Q15276 474 4 KAIKAMTPEQEETASLLSSVT O42351 472 4 RAIKAMTPEQEETASLLSSVT O35551 474 4 RAIKAMTPEQEETASLLSSVT P70609 474 4 RAIKAMTPEQEETASLLSSVT O35550 474 4 RABAPTIN9 Length of motif = 21 Motif number = 9 Rabaptin motif IX - 1 PCODE ST INT SAYVSPSGYRLVSETEWNLLQ O95369 499 4 SAYVSPSGYRLVSETEWNLLQ Q15276 499 4 SAYVSPSGYRLVSETEWNLLQ O42351 497 4 SAYVSPSGYRLVSETEWNLLQ O35551 499 4 SAYVSPSGYRLVSETEWNLLQ P70609 499 4 SAYVSPSGYRLVSETEWNLLQ O35550 499 4 RABAPTIN10 Length of motif = 17 Motif number = 10 Rabaptin motif X - 1 PCODE ST INT QISALVLRAQASEILLE O95369 595 75 QISALVLRAQASEILLE Q15276 595 75 QISLLMVKCQKSENFLN O42351 593 75 QISALVLRAQASEVLLE O35551 595 75 QISALVLRAQASEVLLE P70609 595 75 QISALVLRAQASEVLLE O35550 595 75 RABAPTIN11 Length of motif = 23 Motif number = 11 Rabaptin motif XI - 1 PCODE ST INT VQEQMAVLMQSREQVSEELVRLQ O95369 624 12 VQEQMAVLMQSREQVSEELVRLQ Q15276 624 12 VQEQMAVLTQSREQVSEELVRLQ O42351 622 12 VQEQMAVLMQSREQVSEELVRLQ O35551 624 12 VQEQMAVLMQSREQVSEELVRLQ P70609 624 12 VQEQMAVLMQSREQVSEELVRLQ O35550 624 12 RABAPTIN12 Length of motif = 21 Motif number = 12 Rabaptin motif XII - 1 PCODE ST INT ALRELVLKYREDIINVRTAAD O95369 676 29 ALRELVLKYREDIINVRTAAD Q15276 676 29 ELRELILKYREDIISVRTAAD O42351 674 29 VLRELVLKYRENIVHVRTAAD O35551 676 29 VLRELVLKYRENIVHVRTAAD P70609 676 29 VLRELVLKYRENIVHVRTAAD O35550 676 29 FINAL MOTIF SETS RABAPTIN1 Length of motif = 20 Motif number = 1 Rabaptin motif I - 1 PCODE ST INT DVSLQQRVAELEKINAEFLR O35550 11 11 DVSLQQRVAELEKINAEFLR O35551 11 11 DVSLQQRVAELEKINAEFLR O95369 11 11 DVSLQQRVAELEKINAEFLR Q15276 11 11 DVSLQQRVAELEKINAEFLR P70609 11 11 DVALLQRVAELEKVNAEFLR O42351 11 11 RABAPTIN2 Length of motif = 18 Motif number = 2 Rabaptin motif II - 1 PCODE ST INT LWEAQAEMENIKAIATVS O35550 78 47 LWEAQAEMENIKAIATVS O35551 78 47 LWEAQAEMENIKAIATVS O95369 78 47 LWEAQAEMENIKAIATVS Q15276 78 47 LSEAQADMENIKAIATVS P70609 78 47 LMEAHAEMENIKAIATVS O42351 78 47 RABAPTIN3 Length of motif = 19 Motif number = 3 Rabaptin motif III - 1 PCODE ST INT AEKLRSVVMPMEKEIAALK O35550 181 85 AEKLRSVVMPMEKEIAALK O35551 181 85 AEKLRSVVMPMEKEIAALK O95369 181 85 AEKLRSVVMPMEKEIAALK Q15276 181 85 AEKLRSVVMPMEKEIAALK P70609 181 85 AEKLRSVVMPMEKEIAALK O42351 181 85 RABAPTIN4 Length of motif = 22 Motif number = 4 Rabaptin motif IV - 1 PCODE ST INT CRTDLEMYVAVLNTQKSVLQED O35550 230 30 CRTDLEMYVAVLNTQKSVLQED O35551 230 30 CRTDLEMYVAVLNTQKSVLQED O95369 230 30 CRTDLEMYVAVLNTQKSVLQED Q15276 230 30 CRTDLEMYVAVLNTQKSVLQED P70609 230 30 CRTDLEMYVAVLNTQKSVLQED O42351 230 30 RABAPTIN5 Length of motif = 18 Motif number = 5 Rabaptin motif V - 1 PCODE ST INT HLDSTHGSVHSLDADLLL O35550 367 115 HLDSTHGSVHSLDADLML O35551 367 115 HLDSTRGSVHSLDAGLLL O95369 367 115 HLDSTRGSVHSLDAGLLL Q15276 367 115 HLDSTHGSVHSLDADLLL P70609 367 115 HLNSTHSSVHSLDADLLL O42351 365 113 RABAPTIN6 Length of motif = 19 Motif number = 6 Rabaptin motif VI - 1 PCODE ST INT LQSKALGYNYKAKSAGNLD O35550 417 32 LQSKALGYNYKAKSAGNLD O35551 417 32 LQSKALGYNYKAKSAGNLD O95369 417 32 LQSKALGYNYKAKSAGNLD Q15276 417 32 LQSKALGYNYKAKSAGNLD P70609 417 32 LQSKALGYNNKAKSAGNLD O42351 415 32 RABAPTIN7 Length of motif = 21 Motif number = 7 Rabaptin motif VII - 1 PCODE ST INT SENFDTVSLGSLQMPSGFMLT O35550 449 13 SENFDTVSLGSLQMPSGFMLT O35551 449 13 SENFDTASLGSLQMPSGFMLT O95369 449 13 SENFDTASLGSLQMPSGFMLT Q15276 449 13 SENFDTVSLESLQMPSGFMLT P70609 449 13 SENYDTASLGSLQMPSGFMLT O42351 447 13 RABAPTIN8 Length of motif = 21 Motif number = 8 Rabaptin motif VIII - 1 PCODE ST INT RAIKAMTPEQEETASLLSSVT O35550 474 4 RAIKAMTPEQEETASLLSSVT O35551 474 4 RAIKAMTPEQEETASLLSSVT O95369 474 4 RAIKAMTPEQEETASLLSSVT Q15276 474 4 RAIKAMTPEQEETASLLSSVT P70609 474 4 KAIKAMTPEQEETASLLSSVT O42351 472 4 RABAPTIN9 Length of motif = 21 Motif number = 9 Rabaptin motif IX - 1 PCODE ST INT SAYVSPSGYRLVSETEWNLLQ O35550 499 4 SAYVSPSGYRLVSETEWNLLQ O35551 499 4 SAYVSPSGYRLVSETEWNLLQ O95369 499 4 SAYVSPSGYRLVSETEWNLLQ Q15276 499 4 SAYVSPSGYRLVSETEWNLLQ P70609 499 4 SAYVSPSGYRLVSETEWNLLQ O42351 497 4 RABAPTIN10 Length of motif = 17 Motif number = 10 Rabaptin motif X - 1 PCODE ST INT QISALVLRAQASEVLLE O35550 595 75 QISALVLRAQASEVLLE O35551 595 75 QISALVLRAQASEILLE O95369 595 75 QISALVLRAQASEILLE Q15276 595 75 QISALVLRAQASEVLLE P70609 595 75 QISLLMVKCQKSENFLN O42351 593 75 RABAPTIN11 Length of motif = 23 Motif number = 11 Rabaptin motif XI - 1 PCODE ST INT VQEQMAVLMQSREQVSEELVRLQ O35550 624 12 VQEQMAVLMQSREQVSEELVRLQ O35551 624 12 VQEQMAVLMQSREQVSEELVRLQ O95369 624 12 VQEQMAVLMQSREQVSEELVRLQ Q15276 624 12 VQEQMAVLMQSREQVSEELVRLQ P70609 624 12 VQEQMAVLTQSREQVSEELVRLQ O42351 622 12 RABAPTIN12 Length of motif = 21 Motif number = 12 Rabaptin motif XII - 1 PCODE ST INT VLRELVLKYRENIVHVRTAAD O35550 676 29 VLRELVLKYRENIVHVRTAAD O35551 676 29 ALRELVLKYREDIINVRTAAD O95369 676 29 ALRELVLKYREDIINVRTAAD Q15276 676 29 VLRELVLKYRENIVHVRTAAD P70609 676 29 ELRELILKYREDIISVRTAAD O42351 674 29

User query: Display/Full Code "RABAPTIN"