WORKLIST ENTRIES (1):
PHPHLIPASED View alignment Phospholipase D signature
Type of fingerprint: COMPOUND with 9 elements
Links:
INTERPRO; IPR001028
PFAM; PF00614 PLDc
Creation date 27-MAY-1997; UPDATE 07-JUN-1999
1. SCALLON, B.J., FUNG, W.J., TSANG, T.C., LI, S., KADO-FONG, H.,
HUANG, K.S. AND KOCHAN, J.P.
Primary structure and functional activity of a phosphatidylinositol-
glycan-specific phospholipase D.
SCIENCE 252 446-448 (1991).
2. HOENER M.C., BRODBECK U.
Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic
glycoprotein that in serum is associated with high-density lipoproteins.
EUR.J.BIOCHEM. 206(3) 747-757 (1992).
Phosphatidylinositol-glycan-specific phospholipase D is an extracellular
amphiphilic glycoprotein [1,2]: it hydrolyses the inositol phosphate linkage
in proteins anchored by phosphatidylinositol glycans, releasing these
proteins from the membrane. The enzyme catalyses the reaction: glycoprotein
phosphatidylinositol + H(2)O = phosphatidate + glycoprotein inositol.
PHPHLIPASED is a 9-element fingerprint that provides a signature for
phospholipase D. The fingerprint was derived from an initial alignment
of 3 sequences: the motifs were drawn from short conserved regions
spanning the full alignment length. A single iteration on OWL29.3 was
required to reach convergence, no further sequences being identified
beyond the starting set. A single partial match was found, PHLD_HUMAN,
a composite sequence a phospholipase D fragments.
An update on SPTR37_9f identified a true set of 4 sequences.
SUMMARY INFORMATION
4 codes involving 9 elements
0 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
9| 4 4 4 4 4 4 4 4 4
8| 0 0 0 0 0 0 0 0 0
7| 0 0 0 0 0 0 0 0 0
6| 0 0 0 0 0 0 0 0 0
5| 0 0 0 0 0 0 0 0 0
4| 0 0 0 0 0 0 0 0 0
3| 0 0 0 0 0 0 0 0 0
2| 0 0 0 0 0 0 0 0 0
--+----------------------------------------------
| 1 2 3 4 5 6 7 8 9
True positives..
PHL2_HUMAN PHL1_HUMAN O70362 PHLD_BOVIN
PROTEIN TITLES
PHL2_HUMAN PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D 2 PRECU
PHL1_HUMAN PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D 1 PRECU
O70362 GLYCOSYLPHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE D PRECUR
PHLD_BOVIN PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D PRECURS
SCAN HISTORY
OWL29_3 1 50 NSINGLE
SPTR37_9f 2 5 NSINGLE
INITIAL MOTIF SETS
PHPHLIPASED1 Length of motif = 16 Motif number = 1
Phospholipase D motif I - 1
PCODE ST INT
GLSTHIEIGHRALEFL HUMPHOSPDL 26 26
GISTHIEIGHRALEFL PHLD_BOVIN 25 25
GLSTHVEIGHRALEFL HUMPHOSPDP 25 25
PHPHLIPASED2 Length of motif = 22 Motif number = 2
Phospholipase D motif II - 1
PCODE ST INT
FHDVSESTHWTPFLNASVHYIR HUMPHOSPDL 81 39
FHDVSESTHWTPFLNASVHYIR PHLD_BOVIN 80 39
FHDVSESTHWTPFLNASVHYIR HUMPHOSPDP 80 39
PHPHLIPASED3 Length of motif = 14 Motif number = 3
Phospholipase D motif III - 1
PCODE ST INT
HGSYSEAHSAGDFG HUMPHOSPDL 152 49
HNSYPEAHPAGDFG PHLD_BOVIN 151 49
HGSYSEAHSAGDFG HUMPHOSPDP 151 49
PHPHLIPASED4 Length of motif = 14 Motif number = 4
Phospholipase D motif IV - 1
PCODE ST INT
GGDVLSQFEFNFNY HUMPHOSPDL 165 -1
GGDVLSQFEFKFNY PHLD_BOVIN 164 -1
GGDVLSQFEFNFNY HUMPHOSPDP 164 -1
PHPHLIPASED5 Length of motif = 24 Motif number = 5
Phospholipase D motif V - 1
PCODE ST INT
MTSADLNQDGYGDLVVGAPGYSRP HUMPHOSPDL 386 207
MTSADLNQDGYGDLVVGAPGYSHP PHLD_BOVIN 384 206
MTSADLNQDGHGDLVVGAPGYSRP HUMPHOSPDP 385 207
PHPHLIPASED6 Length of motif = 23 Motif number = 6
Phospholipase D motif VI - 1
PCODE ST INT
GHVLMNGTLTQVLLVGAPTRDDV HUMPHOSPDL 655 245
GHVMVNGTRTQVLLVGAPTQDVV PHLD_BOVIN 653 245
GHVLMNGTLKQVLLVGAPTYDDV HUMPHOSPDP 654 245
PHPHLIPASED7 Length of motif = 26 Motif number = 7
Phospholipase D motif VII - 1
PCODE ST INT
VAAPLRIADVTSGLIGGEDGRVYVYN HUMPHOSPDL 738 60
VAAPLRITDATAGLMGEEDGRVYVFN PHLD_BOVIN 736 60
MAAPLRIADVTSGLIGGEDGRVYVYN HUMPHOSPDP 737 60
PHPHLIPASED8 Length of motif = 20 Motif number = 8
Phospholipase D motif VIII - 1
PCODE ST INT
DMTGKCKSWMTPCPEEKAQY HUMPHOSPDL 771 7
DVTGKCKSWVTPCPEEKAQY PHLD_BOVIN 769 7
DMTGKCKSWITPCPEEKAQY HUMPHOSPDP 770 7
PHPHLIPASED9 Length of motif = 21 Motif number = 9
Phospholipase D motif IX - 1
PCODE ST INT
VLISPEASSRFGSSLITVRSK HUMPHOSPDL 791 0
VLISPEAGSRFGSSVITVRSK PHLD_BOVIN 789 0
VLISPEASSRFGSSLITVRSK HUMPHOSPDP 790 0
FINAL MOTIF SETS
PHPHLIPASED1 Length of motif = 16 Motif number = 1
Phospholipase D motif I - 2
PCODE ST INT
GLSTHIEIGHRALEFL PHL2_HUMAN 26 26
GLSTHVEIGHRALEFL PHL1_HUMAN 25 25
GLSTHVEIGHRALEFL O70362 25 25
GISTHIEIGHRALEFL PHLD_BOVIN 25 25
PHPHLIPASED2 Length of motif = 22 Motif number = 2
Phospholipase D motif II - 2
PCODE ST INT
FHDVSESTHWTPFLNASVHYIR PHL2_HUMAN 81 39
FHDVSESTHWTPFLNASVHYIR PHL1_HUMAN 80 39
YHDVSERTHWTPFLNASIHYIR O70362 80 39
FHDVSESTHWTPFLNASVHYIR PHLD_BOVIN 80 39
PHPHLIPASED3 Length of motif = 14 Motif number = 3
Phospholipase D motif III - 2
PCODE ST INT
HGSYSEAHSAGDFG PHL2_HUMAN 152 49
HGSYSEAHSAGDFG PHL1_HUMAN 151 49
YNSYSDAHSAGDFG O70362 147 45
HNSYPEAHPAGDFG PHLD_BOVIN 151 49
PHPHLIPASED4 Length of motif = 14 Motif number = 4
Phospholipase D motif IV - 2
PCODE ST INT
GGDVLSQFEFNFNY PHL2_HUMAN 165 -1
GGDVLSQFEFNFNY PHL1_HUMAN 164 -1
GGDVLSQFEFNFNY O70362 160 -1
GGDVLSQFEFKFNY PHLD_BOVIN 164 -1
PHPHLIPASED5 Length of motif = 24 Motif number = 5
Phospholipase D motif V - 2
PCODE ST INT
MTSADLNQDGYGDLVVGAPGYSRP PHL2_HUMAN 386 207
MTSADLNQDGHGDLVVGAPGYSRP PHL1_HUMAN 385 207
MTSADLNQDGHGDLVVGAPGYSHP O70362 382 208
MTSADLNQDGYGDLVVGAPGYSHP PHLD_BOVIN 384 206
PHPHLIPASED6 Length of motif = 23 Motif number = 6
Phospholipase D motif VI - 2
PCODE ST INT
GHVLMNGTLTQVLLVGAPTRDDV PHL2_HUMAN 655 245
GHVLMNGTLKQVLLVGAPTYDDV PHL1_HUMAN 654 245
GYVRVNGTLTQVLLVGAPTHDDV O70362 650 244
GHVMVNGTRTQVLLVGAPTQDVV PHLD_BOVIN 653 245
PHPHLIPASED7 Length of motif = 26 Motif number = 7
Phospholipase D motif VII - 2
PCODE ST INT
VAAPLRIADVTSGLIGGEDGRVYVYN PHL2_HUMAN 738 60
MAAPLRIADVTSGLIGGEDGRVYVYN PHL1_HUMAN 737 60
MAAPLRITDVTSGLLGGEDGRVYIYN O70362 734 61
VAAPLRITDATAGLMGEEDGRVYVFN PHLD_BOVIN 736 60
PHPHLIPASED8 Length of motif = 20 Motif number = 8
Phospholipase D motif VIII - 2
PCODE ST INT
DMTGKCKSWMTPCPEEKAQY PHL2_HUMAN 771 7
DMTGKCKSWITPCPEEKAQY PHL1_HUMAN 770 7
DMTGKCKSWMTPCPEEKAQY O70362 767 7
DVTGKCKSWVTPCPEEKAQY PHLD_BOVIN 769 7
PHPHLIPASED9 Length of motif = 21 Motif number = 9
Phospholipase D motif IX - 2
PCODE ST INT
VLISPEASSRFGSSLITVRSK PHL2_HUMAN 791 0
VLISPEASSRFGSSLITVRSK PHL1_HUMAN 790 0
VLTSPEASSRFGSSLVSVRSK O70362 787 0
VLISPEAGSRFGSSVITVRSK PHLD_BOVIN 789 0
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