WORKLIST ENTRIES (1):

PBPGOBP View alignment View Structure         Pheromone/general odorant binding protein signature
 Type of fingerprint: COMPOUND with 6  elements
Links:
   PRINTS; PR00485 MEALWORMBTLB
   INTERPRO; IPR000746

 Creation date 02-APR-1996; UPDATE 07-JUN-1999

   1. MCKENNA, M.P., HEKMAT-SCAFE, D.S., GAINES, P. AND CARLSON, J.R.
   Putative Drosophila pheromone-binding proteins expressed in a subregion
   of the olfactory system.
   J.BIOL.CHEM. 269(23) 16340-16347 (1994).

   Pheromone binding proteins (PBPs) are abundant, secreted antennal proteins 
   present in olfactory sensilla - specifically, they lie in the lymph that
   surrounds the dendrites of olfactory receptor neurons [1]. They are thought
   to transport hydrophobic pheromones across this aqueous fluid to receptor
   molecules in the dendritic membranes. Another group of proteins, the
   so-called general odorant-binding proteins (GOBPs) have also been found
   in moth antennae. They share a high level of sequence similarity with the
   PBPs and are believed to carry odorants rather than pheromones. This
   family is distinct from the vertebrate odorant-binding proteins (OBPs).
   
   PBPGOBP is a 6-element fingerprint that provides a signature for the
   PBP/GOBP family. The fingerprint was derived from an initial alignment of
   7 sequences: the motifs were drawn from short conserved regions spanning
   virtually the full alignment length. Two iterations on OWL27.1 were
   required to reach convergence, at which point a true set comprising 14
   sequences was identified.
  
   An update on SPTR37_9f identified a true set of 17 sequences, and 1
   partial match.

  SUMMARY INFORMATION
     17 codes involving  6 elements
      1 codes involving  5 elements
      0 codes involving  4 elements
      0 codes involving  3 elements
      0 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    6|  17   17   17   17   17   17  
    5|   0    1    1    1    1    1  
    4|   0    0    0    0    0    0  
    3|   0    0    0    0    0    0  
    2|   0    0    0    0    0    0  
   --+-------------------------------
     |   1    2    3    4    5    6  

True positives..
 OBP2_MANSE     PBP_BOMMO      O77227         PBP_HELVI      
 OBP2_HELVI     OBP2_ANTPE     PBP_ANTPO      PBP2_ANTPE     
 OBP1_BOMMO     PBP_MANSE      OBP1_ANTPE     OBP1_MANSE     
 PBP1_ANTPE     OBP2_BOMMO     OBP1_HELVI     O16105         
 O16106         
Subfamily:  Codes involving 5 elements
 Subfamily True positives..
 O61561         


  PROTEIN TITLES
   OBP2_MANSE       GENERAL ODORANT-BINDING PROTEIN 2 PRECURSOR (GOBP 2) - MANDU
   PBP_BOMMO        PHEROMONE-BINDING PROTEIN PRECURSOR (PBP) - BOMBYX MORI (SIL
   O77227           PHEROMONE BINDING PROTEIN - HELIOTHIS ZEA (CORN EARWORM) (BO
   PBP_HELVI        PHEROMONE-BINDING PROTEIN PRECURSOR (PBP) - HELIOTHIS VIRESC
   OBP2_HELVI       GENERAL ODORANT-BINDING PROTEIN 2 PRECURSOR (GOBP 2) - HELIO
   OBP2_ANTPE       GENERAL ODORANT-BINDING PROTEIN 2 PRECURSOR (GOBP 2) (PHEROM
   PBP_ANTPO        PHEROMONE-BINDING PROTEIN PRECURSOR (PBP) - ANTHERAEA POLYPH
   PBP2_ANTPE       PHEROMONE-BINDING PROTEIN 2 PRECURSOR (PBP 2) (APR-2) - ANTH
   OBP1_BOMMO       GENERAL ODORANT-BINDING PROTEIN 1 PRECURSOR (GOBP1) (GOBP2) 
   PBP_MANSE        PHEROMONE-BINDING PROTEIN PRECURSOR (PBP) - MANDUCA SEXTA (T
   OBP1_ANTPE       GENERAL ODORANT-BINDING PROTEIN 1 PRECURSOR (GOBP 1) - ANTHE
   OBP1_MANSE       GENERAL ODORANT-BINDING PROTEIN 1 PRECURSOR (GOBP 1) - MANDU
   PBP1_ANTPE       PHEROMONE-BINDING PROTEIN 1 PRECURSOR (PBP 1) (APR-1) - ANTH
   OBP2_BOMMO       GENERAL ODORANT-BINDING PROTEIN 2 PRECURSOR (GOBP2) (GOBP1) 
   OBP1_HELVI       GENERAL ODORANT-BINDING PROTEIN 1 PRECURSOR (GOBP 1) - HELIO
   O16105           PHEROMONE BINDING PROTEIN 1 PRECURSOR - LYMANTRIA DISPAR (GY
   O16106           PHEROMONE BINDING PROTEIN 2 - LYMANTRIA DISPAR (GYPSY MOTH).
 
   O61561           PHEROMONE BINDING PROTEIN 2 PRECURSOR - MAMESTRA BRASSICAE.

SCAN HISTORY OWL27_1 2 100 NSINGLE SPTR37_9f 2 23 NSINGLE INITIAL MOTIF SETS PBPGOBP1 Length of motif = 23 Motif number = 1 PBP/GOBP motif I - 1 PCODE ST INT EVMKNLCLNFGKALDECKAEMNL MOTPBPB 29 29 EVMSHVTAHFGKALEECREESGL OBP2_MANSE 23 23 EVMSHVTAHFGKALEECRDESGL A60292 22 22 QVMKDVTLGFGQALEQCREESQL OBP1_MANSE 25 25 EVMKNLCMNYGKAMDQCKQELNL S14448 25 25 EIMKNLSNNFGKAMDQCKDELSL PBP_ANTPO 24 24 EIIKNLSQNFCKAMDQCKQELNI S14269 24 24 PBPGOBP2 Length of motif = 17 Motif number = 2 PBP/GOBP motif II - 1 PCODE ST INT KDDFANFWVEGYEVSNR MOTPBPB 56 4 MDEFKHFWREDFEVVHR OBP2_MANSE 50 4 LNEFKHFWSEDFDVVHR A60292 49 4 MEEFFHFWREDFKFEHR OBP1_MANSE 52 4 IADLYNFWKDDYVMTDR S14448 52 4 VADLYNFWKDDYVMTDR PBP_ANTPO 51 4 IADLYNFWKDDYVMTDR S14269 51 4 PBPGOBP3 Length of motif = 16 Motif number = 3 PBP/GOBP motif III - 1 PCODE ST INT DTGCAILCLSKKLDMI MOTPBPB 73 0 ELGCAIICMSNKFELL OBP2_MANSE 67 0 ELGCAIICMSNKFSLL A60292 66 0 ELGCALQCMSRHFNLL OBP1_MANSE 69 0 LAGCAINCLSTKLDIV S14448 69 0 LAGCAINCLATKLDVV PBP_ANTPO 68 0 LAGCAINCMATKLDVV S14269 68 0 PBPGOBP4 Length of motif = 15 Motif number = 4 PBP/GOBP motif IV - 1 PCODE ST INT MAKQLLDIVHNCENS MOTPBPB 112 23 LSEKMVQLIHNCEKQ OBP2_MANSE 106 23 LSAKMVNLIHNCEKQ A60292 105 23 LSKTMVELIHNCELQ OBP1_MANSE 108 23 MAHELVDIIHGCEKS S14448 108 23 MAQQLVDIIHGCEKS PBP_ANTPO 107 23 MAQQLVDIIHGCEKS S14269 107 23 PBPGOBP5 Length of motif = 19 Motif number = 5 PBP/GOBP motif V - 1 PCODE ST INT DACLKTLDIAKCFKKEIHK MOTPBPB 132 5 DDCDRVVKVAACFKKDAKK OBP2_MANSE 126 5 DECDRVVKVAACFKVDAKK A60292 125 5 DHCWRILRVAECFKISCTK OBP1_MANSE 128 5 DKCIKTMDIAMCFKKEIHK S14448 128 5 DKCMKTIDVAMCFKKEIHK PBP_ANTPO 127 5 DKCMKTIDVAMCFKKEIHK S14269 127 5 PBPGOBP6 Length of motif = 10 Motif number = 6 PBP/GOBP motif VI - 1 PCODE ST INT DLVVGEVLAE MOTPBPB 158 7 EVAMIEAVIE OBP2_MANSE 150 5 EVAMIEAVIE A60292 149 5 EVMMAEFIME OBP1_MANSE 154 7 DLVVGEVLAE S14448 154 7 DLVIGEVLAE PBP_ANTPO 153 7 DVVLGEVLAE S14269 153 7 FINAL MOTIF SETS PBPGOBP1 Length of motif = 23 Motif number = 1 PBP/GOBP motif I - 2 PCODE ST INT EVMSHVTAHFGKALEECREESGL OBP2_MANSE 23 23 EVMKNLSLNFGKALDECKKEMTL PBP_BOMMO 25 25 DVIKNLSMNFAKPLEDCKKEMDL O77227 23 23 DVMKNLSMNFAKPLEDCKKEMDL PBP_HELVI 23 23 EVMSHVTAHFGKALEECREESGL OBP2_HELVI 24 24 EVMSHVTAHFGKALEECRDESGL OBP2_ANTPE 22 22 EIMKNLSNNFGKAMDQCKDELSL PBP_ANTPO 24 24 EVMKNLCMNYGKAMDQCKQELNL PBP2_ANTPE 25 25 EVMSHVTAHFGKTLEECREESGL OBP1_BOMMO 22 22 DVMKNLCLNFGKALDECKAEMNL PBP_MANSE 29 29 NVMKDVTLGFGQALEKCREESQL OBP1_ANTPE 25 25 QVMKDVTLGFGQALEQCREESQL OBP1_MANSE 25 25 EIIKNLSQNFCKAMDQCKQELNI PBP1_ANTPE 24 24 YVMKDVTLGFGQALEQCREESQL OBP2_BOMMO 21 21 NVMKDVTLGFGQALDKCREESQL OBP1_HELVI 22 22 EVMKQMTINFAKPMEACKQELNV O16105 22 22 DVMHQMALKFGKPIKLCQQELGA O16106 23 23 PBPGOBP2 Length of motif = 17 Motif number = 2 PBP/GOBP motif II - 2 PCODE ST INT MDEFKHFWREDFEVVHR OBP2_MANSE 50 4 NEDFYNFWKEGYEIKNR PBP_BOMMO 52 4 TTDFYNFWKEGYEFTNR O77227 50 4 TTDFYNFWKEGYEFTNR PBP_HELVI 50 4 LEEFQHFWREDFEVVHR OBP2_HELVI 51 4 LNEFKHFWSEDFDVVHR OBP2_ANTPE 49 4 VADLYNFWKDDYVMTDR PBP_ANTPO 51 4 IADLYNFWKDDYVMTDR PBP2_ANTPE 52 4 LDEFKHFWSDDFDVVHR OBP1_BOMMO 49 4 KDDFANFWVEGYEVSNR PBP_MANSE 56 4 MEEFFHFWSEDFKFEHR OBP1_ANTPE 52 4 MEEFFHFWREDFKFEHR OBP1_MANSE 52 4 IADLYNFWKDDYVMTDR PBP1_ANTPE 51 4 MEEFFHFWNDDFKFEHR OBP2_BOMMO 48 4 MEEFFHFWRDDFKFEHR OBP1_HELVI 49 4 MQDFFNFWKEGYQITNR O16105 49 4 VKEFLDFWKDGYVMKDR O16106 50 4 PBPGOBP3 Length of motif = 16 Motif number = 3 PBP/GOBP motif III - 2 PCODE ST INT ELGCAIICMSNKFELL OBP2_MANSE 67 0 ETGCAIMCLSTKLNML PBP_BOMMO 69 0 QTGCAILCLSSKLELL O77227 67 0 HTGCASLCLSSKLELL PBP_HELVI 67 0 ELGCAIICMSNKFSLL OBP2_HELVI 68 0 ELGCAIICMSNKFSLL OBP2_ANTPE 66 0 LAGCAINCLATKLDVV PBP_ANTPO 68 0 LAGCAINCLSTKLDIV PBP2_ANTPE 69 0 ELGCAIICMSNKFSLM OBP1_BOMMO 66 0 DTGCAILCLSKKLDMI PBP_MANSE 73 0 ELGCAILCMSRHFNLL OBP1_ANTPE 69 0 ELGCALQCMSRHFNLL OBP1_MANSE 69 0 LAGCAINCMATKLDVV PBP1_ANTPE 68 0 ELGCAIQCMSRHFNLL OBP2_BOMMO 65 0 ELGCAIQCMSRHFNLL OBP1_HELVI 66 0 EAGCVILCLAKKLELL O16105 66 0 QTGCMLICMAMKLELL O16106 67 0 PBPGOBP4 Length of motif = 15 Motif number = 4 PBP/GOBP motif IV - 2 PCODE ST INT LSEKMVQLIHNCEKQ OBP2_MANSE 106 23 MAQQLIDIVHGCEKS PBP_BOMMO 108 23 MAKQLVDLIHGCAQS O77227 106 23 MAKQLVDMIHGCSQS PBP_HELVI 106 23 LSEKLVELIHNCEKK OBP2_HELVI 107 23 LSAKMVNLIHNCEKQ OBP2_ANTPE 105 23 MAQQLVDIIHGCEKS PBP_ANTPO 107 23 MAHELVDIIHGCEKS PBP2_ANTPE 108 23 LAEKMVKLIHNCEKQ OBP1_BOMMO 105 23 MAKQLLDIIHNCENS PBP_MANSE 112 23 LSKHMVNLIHSCEQQ OBP1_ANTPE 108 23 LSKTMVELIHNCELQ OBP1_MANSE 108 23 MAQQLVDIIHGCEKS PBP1_ANTPE 107 23 LSQKMIDMIHTCEKT OBP2_BOMMO 104 23 LARQMVELIHSCEKQ OBP1_HELVI 105 23 MAKQLLDIKHSCEKV O16105 105 23 MAQQIIDIVHGCTTT O16106 106 23 PBPGOBP5 Length of motif = 19 Motif number = 5 PBP/GOBP motif V - 2 PCODE ST INT DDCDRVVKVAACFKKDAKK OBP2_MANSE 126 5 DKCIWTLGVATCFKAEIHK PBP_BOMMO 128 5 DPCMKTLNVAKCFKAKIHE O77227 127 6 DPCMKALNVAKCFKAKIHE PBP_HELVI 127 6 DDCDRVVKVAACFKVDAKA OBP2_HELVI 127 5 DECDRVVKVAACFKVDAKK OBP2_ANTPE 125 5 DKCMKTIDVAMCFKKEIHK PBP_ANTPO 127 5 DKCIKTMDIAMCFKKEIHK PBP2_ANTPE 128 5 DDCTRVVKVAACFKKDSRK OBP1_BOMMO 125 5 DACLKTLDIAKCFKKEIHK PBP_MANSE 132 5 DHCWRILRVAECFKRSCQE OBP1_ANTPE 128 5 DHCWRILRVAECFKISCTK OBP1_MANSE 128 5 DKCMKTIDVAMCFKKEIHK PBP1_ANTPE 127 5 DHCWRILRVAECFKDACNK OBP2_BOMMO 124 5 DHCWRISHLADCFKSSCVQ OBP1_HELVI 125 5 DPCQTMLNLAMCFKAEIHK O16105 126 6 DPCQRAVNVAMCFKAHVHK O16106 128 7 PBPGOBP6 Length of motif = 10 Motif number = 6 PBP/GOBP motif VI - 2 PCODE ST INT EVAMIEAVIE OBP2_MANSE 150 5 DVAVGEILAE PBP_BOMMO 154 7 DLVVGEVLAE O77227 153 7 ELVVGEVLAE PBP_HELVI 153 7 EVTMIEAVME OBP2_HELVI 151 5 EVAMIEAVIE OBP2_ANTPE 149 5 DLVIGEVLAE PBP_ANTPO 153 7 DLVVGEVLAE PBP2_ANTPE 154 7 EVAMIEAVIE OBP1_BOMMO 149 5 DLVVGEVLAE PBP_MANSE 158 7 ELLMAEFIME OBP1_ANTPE 154 7 EVMMAEFIME OBP1_MANSE 154 7 DVVLGEVLAE PBP1_ANTPE 153 7 ELILAEFIME OBP2_BOMMO 150 7 ELMMTEFIME OBP1_HELVI 151 7 DVAVGELLAD O16105 152 7 ELLVADFLAE O16106 154 7

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