WORKLIST ENTRIES (1):
PBPGOBP View alignment View Structure Pheromone/general odorant binding protein signature
Type of fingerprint: COMPOUND with 6 elements
Links:
PRINTS; PR00485 MEALWORMBTLB
INTERPRO; IPR000746
Creation date 02-APR-1996; UPDATE 07-JUN-1999
1. MCKENNA, M.P., HEKMAT-SCAFE, D.S., GAINES, P. AND CARLSON, J.R.
Putative Drosophila pheromone-binding proteins expressed in a subregion
of the olfactory system.
J.BIOL.CHEM. 269(23) 16340-16347 (1994).
Pheromone binding proteins (PBPs) are abundant, secreted antennal proteins
present in olfactory sensilla - specifically, they lie in the lymph that
surrounds the dendrites of olfactory receptor neurons [1]. They are thought
to transport hydrophobic pheromones across this aqueous fluid to receptor
molecules in the dendritic membranes. Another group of proteins, the
so-called general odorant-binding proteins (GOBPs) have also been found
in moth antennae. They share a high level of sequence similarity with the
PBPs and are believed to carry odorants rather than pheromones. This
family is distinct from the vertebrate odorant-binding proteins (OBPs).
PBPGOBP is a 6-element fingerprint that provides a signature for the
PBP/GOBP family. The fingerprint was derived from an initial alignment of
7 sequences: the motifs were drawn from short conserved regions spanning
virtually the full alignment length. Two iterations on OWL27.1 were
required to reach convergence, at which point a true set comprising 14
sequences was identified.
An update on SPTR37_9f identified a true set of 17 sequences, and 1
partial match.
SUMMARY INFORMATION
17 codes involving 6 elements
1 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
6| 17 17 17 17 17 17
5| 0 1 1 1 1 1
4| 0 0 0 0 0 0
3| 0 0 0 0 0 0
2| 0 0 0 0 0 0
--+-------------------------------
| 1 2 3 4 5 6
True positives..
OBP2_MANSE PBP_BOMMO O77227 PBP_HELVI
OBP2_HELVI OBP2_ANTPE PBP_ANTPO PBP2_ANTPE
OBP1_BOMMO PBP_MANSE OBP1_ANTPE OBP1_MANSE
PBP1_ANTPE OBP2_BOMMO OBP1_HELVI O16105
O16106
Subfamily: Codes involving 5 elements
Subfamily True positives..
O61561
PROTEIN TITLES
OBP2_MANSE GENERAL ODORANT-BINDING PROTEIN 2 PRECURSOR (GOBP 2) - MANDU
PBP_BOMMO PHEROMONE-BINDING PROTEIN PRECURSOR (PBP) - BOMBYX MORI (SIL
O77227 PHEROMONE BINDING PROTEIN - HELIOTHIS ZEA (CORN EARWORM) (BO
PBP_HELVI PHEROMONE-BINDING PROTEIN PRECURSOR (PBP) - HELIOTHIS VIRESC
OBP2_HELVI GENERAL ODORANT-BINDING PROTEIN 2 PRECURSOR (GOBP 2) - HELIO
OBP2_ANTPE GENERAL ODORANT-BINDING PROTEIN 2 PRECURSOR (GOBP 2) (PHEROM
PBP_ANTPO PHEROMONE-BINDING PROTEIN PRECURSOR (PBP) - ANTHERAEA POLYPH
PBP2_ANTPE PHEROMONE-BINDING PROTEIN 2 PRECURSOR (PBP 2) (APR-2) - ANTH
OBP1_BOMMO GENERAL ODORANT-BINDING PROTEIN 1 PRECURSOR (GOBP1) (GOBP2)
PBP_MANSE PHEROMONE-BINDING PROTEIN PRECURSOR (PBP) - MANDUCA SEXTA (T
OBP1_ANTPE GENERAL ODORANT-BINDING PROTEIN 1 PRECURSOR (GOBP 1) - ANTHE
OBP1_MANSE GENERAL ODORANT-BINDING PROTEIN 1 PRECURSOR (GOBP 1) - MANDU
PBP1_ANTPE PHEROMONE-BINDING PROTEIN 1 PRECURSOR (PBP 1) (APR-1) - ANTH
OBP2_BOMMO GENERAL ODORANT-BINDING PROTEIN 2 PRECURSOR (GOBP2) (GOBP1)
OBP1_HELVI GENERAL ODORANT-BINDING PROTEIN 1 PRECURSOR (GOBP 1) - HELIO
O16105 PHEROMONE BINDING PROTEIN 1 PRECURSOR - LYMANTRIA DISPAR (GY
O16106 PHEROMONE BINDING PROTEIN 2 - LYMANTRIA DISPAR (GYPSY MOTH).
O61561 PHEROMONE BINDING PROTEIN 2 PRECURSOR - MAMESTRA BRASSICAE.
SCAN HISTORY
OWL27_1 2 100 NSINGLE
SPTR37_9f 2 23 NSINGLE
INITIAL MOTIF SETS
PBPGOBP1 Length of motif = 23 Motif number = 1
PBP/GOBP motif I - 1
PCODE ST INT
EVMKNLCLNFGKALDECKAEMNL MOTPBPB 29 29
EVMSHVTAHFGKALEECREESGL OBP2_MANSE 23 23
EVMSHVTAHFGKALEECRDESGL A60292 22 22
QVMKDVTLGFGQALEQCREESQL OBP1_MANSE 25 25
EVMKNLCMNYGKAMDQCKQELNL S14448 25 25
EIMKNLSNNFGKAMDQCKDELSL PBP_ANTPO 24 24
EIIKNLSQNFCKAMDQCKQELNI S14269 24 24
PBPGOBP2 Length of motif = 17 Motif number = 2
PBP/GOBP motif II - 1
PCODE ST INT
KDDFANFWVEGYEVSNR MOTPBPB 56 4
MDEFKHFWREDFEVVHR OBP2_MANSE 50 4
LNEFKHFWSEDFDVVHR A60292 49 4
MEEFFHFWREDFKFEHR OBP1_MANSE 52 4
IADLYNFWKDDYVMTDR S14448 52 4
VADLYNFWKDDYVMTDR PBP_ANTPO 51 4
IADLYNFWKDDYVMTDR S14269 51 4
PBPGOBP3 Length of motif = 16 Motif number = 3
PBP/GOBP motif III - 1
PCODE ST INT
DTGCAILCLSKKLDMI MOTPBPB 73 0
ELGCAIICMSNKFELL OBP2_MANSE 67 0
ELGCAIICMSNKFSLL A60292 66 0
ELGCALQCMSRHFNLL OBP1_MANSE 69 0
LAGCAINCLSTKLDIV S14448 69 0
LAGCAINCLATKLDVV PBP_ANTPO 68 0
LAGCAINCMATKLDVV S14269 68 0
PBPGOBP4 Length of motif = 15 Motif number = 4
PBP/GOBP motif IV - 1
PCODE ST INT
MAKQLLDIVHNCENS MOTPBPB 112 23
LSEKMVQLIHNCEKQ OBP2_MANSE 106 23
LSAKMVNLIHNCEKQ A60292 105 23
LSKTMVELIHNCELQ OBP1_MANSE 108 23
MAHELVDIIHGCEKS S14448 108 23
MAQQLVDIIHGCEKS PBP_ANTPO 107 23
MAQQLVDIIHGCEKS S14269 107 23
PBPGOBP5 Length of motif = 19 Motif number = 5
PBP/GOBP motif V - 1
PCODE ST INT
DACLKTLDIAKCFKKEIHK MOTPBPB 132 5
DDCDRVVKVAACFKKDAKK OBP2_MANSE 126 5
DECDRVVKVAACFKVDAKK A60292 125 5
DHCWRILRVAECFKISCTK OBP1_MANSE 128 5
DKCIKTMDIAMCFKKEIHK S14448 128 5
DKCMKTIDVAMCFKKEIHK PBP_ANTPO 127 5
DKCMKTIDVAMCFKKEIHK S14269 127 5
PBPGOBP6 Length of motif = 10 Motif number = 6
PBP/GOBP motif VI - 1
PCODE ST INT
DLVVGEVLAE MOTPBPB 158 7
EVAMIEAVIE OBP2_MANSE 150 5
EVAMIEAVIE A60292 149 5
EVMMAEFIME OBP1_MANSE 154 7
DLVVGEVLAE S14448 154 7
DLVIGEVLAE PBP_ANTPO 153 7
DVVLGEVLAE S14269 153 7
FINAL MOTIF SETS
PBPGOBP1 Length of motif = 23 Motif number = 1
PBP/GOBP motif I - 2
PCODE ST INT
EVMSHVTAHFGKALEECREESGL OBP2_MANSE 23 23
EVMKNLSLNFGKALDECKKEMTL PBP_BOMMO 25 25
DVIKNLSMNFAKPLEDCKKEMDL O77227 23 23
DVMKNLSMNFAKPLEDCKKEMDL PBP_HELVI 23 23
EVMSHVTAHFGKALEECREESGL OBP2_HELVI 24 24
EVMSHVTAHFGKALEECRDESGL OBP2_ANTPE 22 22
EIMKNLSNNFGKAMDQCKDELSL PBP_ANTPO 24 24
EVMKNLCMNYGKAMDQCKQELNL PBP2_ANTPE 25 25
EVMSHVTAHFGKTLEECREESGL OBP1_BOMMO 22 22
DVMKNLCLNFGKALDECKAEMNL PBP_MANSE 29 29
NVMKDVTLGFGQALEKCREESQL OBP1_ANTPE 25 25
QVMKDVTLGFGQALEQCREESQL OBP1_MANSE 25 25
EIIKNLSQNFCKAMDQCKQELNI PBP1_ANTPE 24 24
YVMKDVTLGFGQALEQCREESQL OBP2_BOMMO 21 21
NVMKDVTLGFGQALDKCREESQL OBP1_HELVI 22 22
EVMKQMTINFAKPMEACKQELNV O16105 22 22
DVMHQMALKFGKPIKLCQQELGA O16106 23 23
PBPGOBP2 Length of motif = 17 Motif number = 2
PBP/GOBP motif II - 2
PCODE ST INT
MDEFKHFWREDFEVVHR OBP2_MANSE 50 4
NEDFYNFWKEGYEIKNR PBP_BOMMO 52 4
TTDFYNFWKEGYEFTNR O77227 50 4
TTDFYNFWKEGYEFTNR PBP_HELVI 50 4
LEEFQHFWREDFEVVHR OBP2_HELVI 51 4
LNEFKHFWSEDFDVVHR OBP2_ANTPE 49 4
VADLYNFWKDDYVMTDR PBP_ANTPO 51 4
IADLYNFWKDDYVMTDR PBP2_ANTPE 52 4
LDEFKHFWSDDFDVVHR OBP1_BOMMO 49 4
KDDFANFWVEGYEVSNR PBP_MANSE 56 4
MEEFFHFWSEDFKFEHR OBP1_ANTPE 52 4
MEEFFHFWREDFKFEHR OBP1_MANSE 52 4
IADLYNFWKDDYVMTDR PBP1_ANTPE 51 4
MEEFFHFWNDDFKFEHR OBP2_BOMMO 48 4
MEEFFHFWRDDFKFEHR OBP1_HELVI 49 4
MQDFFNFWKEGYQITNR O16105 49 4
VKEFLDFWKDGYVMKDR O16106 50 4
PBPGOBP3 Length of motif = 16 Motif number = 3
PBP/GOBP motif III - 2
PCODE ST INT
ELGCAIICMSNKFELL OBP2_MANSE 67 0
ETGCAIMCLSTKLNML PBP_BOMMO 69 0
QTGCAILCLSSKLELL O77227 67 0
HTGCASLCLSSKLELL PBP_HELVI 67 0
ELGCAIICMSNKFSLL OBP2_HELVI 68 0
ELGCAIICMSNKFSLL OBP2_ANTPE 66 0
LAGCAINCLATKLDVV PBP_ANTPO 68 0
LAGCAINCLSTKLDIV PBP2_ANTPE 69 0
ELGCAIICMSNKFSLM OBP1_BOMMO 66 0
DTGCAILCLSKKLDMI PBP_MANSE 73 0
ELGCAILCMSRHFNLL OBP1_ANTPE 69 0
ELGCALQCMSRHFNLL OBP1_MANSE 69 0
LAGCAINCMATKLDVV PBP1_ANTPE 68 0
ELGCAIQCMSRHFNLL OBP2_BOMMO 65 0
ELGCAIQCMSRHFNLL OBP1_HELVI 66 0
EAGCVILCLAKKLELL O16105 66 0
QTGCMLICMAMKLELL O16106 67 0
PBPGOBP4 Length of motif = 15 Motif number = 4
PBP/GOBP motif IV - 2
PCODE ST INT
LSEKMVQLIHNCEKQ OBP2_MANSE 106 23
MAQQLIDIVHGCEKS PBP_BOMMO 108 23
MAKQLVDLIHGCAQS O77227 106 23
MAKQLVDMIHGCSQS PBP_HELVI 106 23
LSEKLVELIHNCEKK OBP2_HELVI 107 23
LSAKMVNLIHNCEKQ OBP2_ANTPE 105 23
MAQQLVDIIHGCEKS PBP_ANTPO 107 23
MAHELVDIIHGCEKS PBP2_ANTPE 108 23
LAEKMVKLIHNCEKQ OBP1_BOMMO 105 23
MAKQLLDIIHNCENS PBP_MANSE 112 23
LSKHMVNLIHSCEQQ OBP1_ANTPE 108 23
LSKTMVELIHNCELQ OBP1_MANSE 108 23
MAQQLVDIIHGCEKS PBP1_ANTPE 107 23
LSQKMIDMIHTCEKT OBP2_BOMMO 104 23
LARQMVELIHSCEKQ OBP1_HELVI 105 23
MAKQLLDIKHSCEKV O16105 105 23
MAQQIIDIVHGCTTT O16106 106 23
PBPGOBP5 Length of motif = 19 Motif number = 5
PBP/GOBP motif V - 2
PCODE ST INT
DDCDRVVKVAACFKKDAKK OBP2_MANSE 126 5
DKCIWTLGVATCFKAEIHK PBP_BOMMO 128 5
DPCMKTLNVAKCFKAKIHE O77227 127 6
DPCMKALNVAKCFKAKIHE PBP_HELVI 127 6
DDCDRVVKVAACFKVDAKA OBP2_HELVI 127 5
DECDRVVKVAACFKVDAKK OBP2_ANTPE 125 5
DKCMKTIDVAMCFKKEIHK PBP_ANTPO 127 5
DKCIKTMDIAMCFKKEIHK PBP2_ANTPE 128 5
DDCTRVVKVAACFKKDSRK OBP1_BOMMO 125 5
DACLKTLDIAKCFKKEIHK PBP_MANSE 132 5
DHCWRILRVAECFKRSCQE OBP1_ANTPE 128 5
DHCWRILRVAECFKISCTK OBP1_MANSE 128 5
DKCMKTIDVAMCFKKEIHK PBP1_ANTPE 127 5
DHCWRILRVAECFKDACNK OBP2_BOMMO 124 5
DHCWRISHLADCFKSSCVQ OBP1_HELVI 125 5
DPCQTMLNLAMCFKAEIHK O16105 126 6
DPCQRAVNVAMCFKAHVHK O16106 128 7
PBPGOBP6 Length of motif = 10 Motif number = 6
PBP/GOBP motif VI - 2
PCODE ST INT
EVAMIEAVIE OBP2_MANSE 150 5
DVAVGEILAE PBP_BOMMO 154 7
DLVVGEVLAE O77227 153 7
ELVVGEVLAE PBP_HELVI 153 7
EVTMIEAVME OBP2_HELVI 151 5
EVAMIEAVIE OBP2_ANTPE 149 5
DLVIGEVLAE PBP_ANTPO 153 7
DLVVGEVLAE PBP2_ANTPE 154 7
EVAMIEAVIE OBP1_BOMMO 149 5
DLVVGEVLAE PBP_MANSE 158 7
ELLMAEFIME OBP1_ANTPE 154 7
EVMMAEFIME OBP1_MANSE 154 7
DVVLGEVLAE PBP1_ANTPE 153 7
ELILAEFIME OBP2_BOMMO 150 7
ELMMTEFIME OBP1_HELVI 151 7
DVAVGELLAD O16105 152 7
ELLVADFLAE O16106 154 7
User query: Display/Full Code "PBPGOBP"