WORKLIST ENTRIES (1):

NTKRECEPTOR1 View alignment     Neurotrophic tyrosine kinase receptor type 1 signature
 Type of fingerprint: COMPOUND with 3  elements
Links:
   PRINTS; PR00109 TYRKINASE
   PRINTS; PR01939 NTKRECEPTOR; PR01941 NTKRECEPTOR2; PR01942 NTKRECEPTOR3
   PDB; 1HE7 3Dinfo; 1WWA 3Dinfo; 1WWW 3Dinfo; 2IFG 3Dinfo
   SCOP; 1HE7; 1WWA; 1WWW; 2IFG
   CATH; 1HE7; 1WWA; 1WWW; 2IFG
   MIM; 191315

 Creation date 03-APR-2008

   1. BOTHWELL, M.
   Functional interactions of neurotrophins and neurotrophin receptors.
   ANNU.REV.NEUROSCI. 18 223-253 (1995).

   2. HUANG, E. AND REICHARDT, L.
   Neurotrophins: roles in neuronal development and function.
   ANNU.REV.NEUROSCI. 24 677-736 (2001).

   3. LEI, L. AND PARADA, L.
   Transcriptional regulation of Trk family neurotrophin receptors.
   CELL.MOL.LIFE SCI. 64 522-532 (2007).

   4. ADLY, M., ASSAF, H., NADA, E., SOLIMAN, M. AND HUSSEIN, M.
   Expression of nerve growth factor and its high-affinity receptor, tyrosine
   kinase A proteins, in the human scalp skin.
   J.CUTAN.PATHOL. 33 559-568 (2006).

   5. YOON, S., CASACCIA-BONNEFIL, P., CARTER, B. AND CHAO, M.
   Competitive signaling between TrkA and p75 nerve growth factor receptors 
   determines cell survival.
   J.NEUROSCI. 18 3273-3281 (1998).

   Neurotrophins are a family of secreted proteins that regulate development, 
   maintenance and function of vertebrate nervous systems. They act via two 
   different classes of receptor: p75NTR (a member of the TNF receptor 
   superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also 
   known as tropomyosin-related kinases (Trks) [1].
  
   NTRKs are multi-domain, transmembrane proteins - in addition to their
   cytoplasmic kinase domains, members of the family possess a number of
   extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand
   binding induces them to dimerise, resulting in activation of their
   cytoplasmic tyrosine kinase domains. The activated receptors couple to a
   variety of intracellular signalling cascades, including the Ras,
   phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP)
   kinase, and phospholipase C (PLC)-gamma pathways [2].
  
   NTRK1 (also termed TrkA) is a high-affinity receptor for nerve growth 
   factor (NGF). The receptor is expressed in the dorsal root ganglia,
   trigeminal ganglia and sympathetic neurons of the peripheral nervous
   system, and in basal forebrain cholinergic neurons [3]. It is also
   expressed in peripheral sites, such as scalp skin [4]. Whereas p75NTR 
   activation by NGF induces apoptosis, NTRK1 mediates the growth factor's 
   cell survival-promoting effects [5].
   
   NTKRECEPTOR1 is a 3-element fingerprint that provides a signature for 
   neurotrophic tyrosine kinase receptor type 1. The fingerprint was derived
   from an initial alignment of 2 sequences: the motifs were drawn from 
   conserved regions spanning the central portion of the alignment, focusing on 
   those sections that characterise NTRK1 but distinguish it from other members
   of the NTRK family: motif 1 lies within the N-terminal extracellular region; 
   and motifs 2 and 3 reside in the cytoplasmic portion of the receptor. Two
   iterations on SPTR55_38f were required to reach convergence, at which point
   a true set comprising 6 sequences was identified.

  SUMMARY INFORMATION
      6 codes involving  3 elements
      0 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    3|   6    6    6  
    2|   0    0    0  
   --+----------------
     |   1    2    3  

True positives..
 NTRK1_HUMAN    NTRK1_MOUSE    NTRK1_RAT      Q90699_CHICK   
 A6NF12_HUMAN   A8K3Z4_HUMAN   


  PROTEIN TITLES
   NTRK1_HUMAN      High affinity nerve growth factor receptor precursor (EC 2.7
   NTRK1_MOUSE      High affinity nerve growth factor receptor precursor (EC 2.7
   NTRK1_RAT        High affinity nerve growth factor receptor precursor (EC 2.7
   Q90699_CHICK     Tyrosine-protein kinase receptor (EC 2.7.10.1) - Gallus gall
   A6NF12_HUMAN     Tyrosine-protein kinase receptor (EC 2.7.10.1) - Homo sapien
   A8K3Z4_HUMAN     cDNA FLJ75372, highly similar to Human trk proto-oncogene in

SCAN HISTORY SPTR55_38f 2 300 NSINGLE INITIAL MOTIF SETS NTKRECEPTOR11 Length of motif = 20 Motif number = 1 Neurotrophic tyrosine kinase receptor type 1 motif I - 1 PCODE ST INT DNPFEFNPEDPIPVSFSPVD NTRK1_HUMAN 380 380 DNPFSFSPEEPIPVSISPLG Q90699_CHICK 373 373 NTKRECEPTOR12 Length of motif = 16 Motif number = 2 Neurotrophic tyrosine kinase receptor type 1 motif II - 1 PCODE ST INT LNKCGRRNKFGINRPA NTRK1_HUMAN 439 39 LNKCGHRSKFGINRSA Q90699_CHICK 433 40 NTKRECEPTOR13 Length of motif = 16 Motif number = 3 Neurotrophic tyrosine kinase receptor type 1 motif III - 1 PCODE ST INT APEDGLAMSLHFMTLG NTRK1_HUMAN 457 2 AQEDDLAMSLHFMNLG Q90699_CHICK 451 2 FINAL MOTIF SETS NTKRECEPTOR11 Length of motif = 20 Motif number = 1 Neurotrophic tyrosine kinase receptor type 1 motif I - 2 PCODE ST INT DNPFEFNPEDPIPVSFSPVD NTRK1_HUMAN 380 380 DNPFEFNPEDPIPVSFSPVD NTRK1_MOUSE 383 383 DNPFEFNPEDPIPVSFSPVD NTRK1_RAT 383 383 DNPFSFSPEEPIPVSISPLG Q90699_CHICK 373 373 DNPFEFNPEDPIPDTNSTSG A6NF12_HUMAN 350 350 DNPFEFNPEDPIPDTNSTSG A8K3Z4_HUMAN 380 380 NTKRECEPTOR12 Length of motif = 16 Motif number = 2 Neurotrophic tyrosine kinase receptor type 1 motif II - 2 PCODE ST INT LNKCGRRNKFGINRPA NTRK1_HUMAN 439 39 LNKCGQRSKFGINRPA NTRK1_MOUSE 442 39 LNKCGQRSKFGINRPA NTRK1_RAT 442 39 LNKCGHRSKFGINRSA Q90699_CHICK 433 40 LNKCGRRNKFGINRPA A6NF12_HUMAN 403 33 LNKCGRRNKFGINRPA A8K3Z4_HUMAN 433 33 NTKRECEPTOR13 Length of motif = 16 Motif number = 3 Neurotrophic tyrosine kinase receptor type 1 motif III - 2 PCODE ST INT APEDGLAMSLHFMTLG NTRK1_HUMAN 457 2 APEDGLAMSLHFMTLG NTRK1_MOUSE 460 2 APEDGLAMSLHFMTLG NTRK1_RAT 460 2 AQEDDLAMSLHFMNLG Q90699_CHICK 451 2 APEDGLAMSLHFMTLG A6NF12_HUMAN 421 2 APEDGLAMSLHFMTLG A8K3Z4_HUMAN 451 2

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