WORKLIST ENTRIES (1):
NTKRECEPTOR View alignment Neurotrophic tyrosine kinase receptor family signature
Type of fingerprint: COMPOUND with 3 elements
Links:
PRINTS; PR00109 TYRKINASE
PRINTS; PR01940 NTKRECEPTOR1; PR01941 NTKRECEPTOR2; PR01942 NTKRECEPTOR3
Creation date 03-APR-2008
1. BOTHWELL, M.
Functional interactions of neurotrophins and neurotrophin receptors.
ANNU.REV.NEUROSCI. 18 223-253 (1995).
2. HUANG, E. AND REICHARDT, L.
Neurotrophins: roles in neuronal development and function.
ANNU.REV.NEUROSCI. 24 677-736 (2001).
Neurotrophins are a family of secreted proteins that regulate development,
maintenance and function of vertebrate nervous systems. They act via two
different classes of receptor: p75NTR (a member of the TNF receptor
superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also
known as tropomyosin-related kinases (Trks) [1].
NTRKs are multi-domain, transmembrane proteins - in addition to their
cytoplasmic kinase domains, members of the family possess a number of
extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand
binding induces them to dimerise, resulting in activation of their
cytoplasmic tyrosine kinase domains. The activated receptors couple to a
variety of intracellular signalling cascades, including the Ras,
phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP)
kinase, and phospholipase C (PLC)-gamma pathways [2].
NTKRECEPTOR is a 3-element fingerprint that provides a signature for the
neurotrophic tyrosine kinase receptor family. The fingerprint was derived
from an initial alignment of 5 sequences: the motifs were drawn from
conserved regions within the N-terminal extracellular domain - motif 1 spans
the first LRR region; and motifs 2 and 3 lie within the first and second
Ig-like C2-type domains, respectively. Two iterations on SPTR55_38f were
required to reach convergence, at which point a true set comprising 34
sequences was identified. A single partial match was also found,
A8WGA3_DANRE, a translated mRNA sequence from zebrafish that fails to match
motif 3.
SUMMARY INFORMATION
34 codes involving 3 elements
1 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
3| 34 34 34
2| 1 1 0
--+----------------
| 1 2 3
True positives..
NTRK3_HUMAN Q96CY4_HUMAN NTRK3_SAIBB NTRK3_PIG
NTRK3_PANTR A4QPD0_MOUSE Q68G04_RAT NTRK3_RAT
NTRK3_MOUSE NTRK3_MACFA NTRK2_HUMAN Q8WXJ7_HUMAN
Q8WXJ5_HUMAN Q5VWE5_HUMAN Q548C2_HUMAN NTRK2_MOUSE
Q3UHE3_MOUSE NTRK2_RAT NTRK3_CHICK Q0VCN4_BOVIN
A6NF12_HUMAN NTRK1_HUMAN A8K3Z4_HUMAN Q7ZXJ8_XENLA
Q9YH44_XENLA Q9YH43_XENLA Q08D53_XENTR NTRK1_MOUSE
NTRK1_RAT NTRK2_CHICK Q5PPW7_XENLA Q90699_CHICK
Q52V39_BRAFL Q52V40_BRAFL
Subfamily: Codes involving 2 elements
Subfamily True positives..
A8WGA3_DANRE
PROTEIN TITLES
NTRK3_HUMAN NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
Q96CY4_HUMAN Neurotrophic tyrosine kinase, receptor, type 3 (Neurotrophic
NTRK3_SAIBB NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
NTRK3_PIG NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
NTRK3_PANTR NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
A4QPD0_MOUSE Neurotrophic tyrosine kinase, receptor, type 3 - Mus musculu
Q68G04_RAT Ntrk3 protein - Rattus norvegicus (Rat).
NTRK3_RAT NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
NTRK3_MOUSE NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
NTRK3_MACFA NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
NTRK2_HUMAN BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (N
Q8WXJ7_HUMAN Tyrosine-protein kinase receptor (EC 2.7.10.1) - Homo sapien
Q8WXJ5_HUMAN Neurotrophin receptor tyrosine kinase type 2 truncated isofo
Q5VWE5_HUMAN Neurotrophic tyrosine kinase, receptor, type 2 (Neurotrophic
Q548C2_HUMAN Neurotrophic tyrosine kinase receptor type 2 - Homo sapiens
NTRK2_MOUSE BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (N
Q3UHE3_MOUSE CDNA, RIKEN full-length enriched library, clone:M5C1042H21 p
NTRK2_RAT BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (N
NTRK3_CHICK NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
Q0VCN4_BOVIN Neurotrophic tyrosine kinase, receptor, type 2 - Bos taurus
A6NF12_HUMAN Tyrosine-protein kinase receptor (EC 2.7.10.1) - Homo sapien
NTRK1_HUMAN High affinity nerve growth factor receptor precursor (EC 2.7
A8K3Z4_HUMAN cDNA FLJ75372, highly similar to Human trk proto-oncogene in
Q7ZXJ8_XENLA Trkb-B-prov protein - Xenopus laevis (African clawed frog).
Q9YH44_XENLA Tyrosine-protein kinase receptor (EC 2.7.10.1) - Xenopus lae
Q9YH43_XENLA Tyrosine-protein kinase receptor (EC 2.7.10.1) - Xenopus lae
Q08D53_XENTR Tyrosine-protein kinase receptor (EC 2.7.10.1) - Xenopus tro
NTRK1_MOUSE High affinity nerve growth factor receptor precursor (EC 2.7
NTRK1_RAT High affinity nerve growth factor receptor precursor (EC 2.7
NTRK2_CHICK BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (N
Q5PPW7_XENLA Ntrk2 protein - Xenopus laevis (African clawed frog).
Q90699_CHICK Tyrosine-protein kinase receptor (EC 2.7.10.1) - Gallus gall
Q52V39_BRAFL Tyrosine-protein kinase receptor (EC 2.7.10.1) - Branchiosto
Q52V40_BRAFL Neurotrophic tyrosine kinase receptor precursor - Branchiost
A8WGA3_DANRE Putative uncharacterized protein - Danio rerio (Zebrafish) (
SCAN HISTORY
SPTR55_38f 2 300 NSINGLE
INITIAL MOTIF SETS
NTKRECEPTOR1 Length of motif = 26 Motif number = 1
Neurotrophic tyrosine kinase receptor family motif I - 1
PCODE ST INT
DVEAYVGLRNLTIVDSGLKFVAHKAF NTRK2_HUMAN 86 86
EVGFYVGLKNLTVVDSGLRFVSRQAF NTRK2_CHICK 85 85
DMELYTGLQKLTIKNSGLRSIQPRAF NTRK3_PANTR 98 98
DMELYTGLQKLTIKNSGLRNIQPRAF NTRK3_MOUSE 98 98
DLRGLGELRNLTIVKSGLRFVAPDAF NTRK1_HUMAN 86 86
NTKRECEPTOR2 Length of motif = 20 Motif number = 2
Neurotrophic tyrosine kinase receptor family motif II - 1
PCODE ST INT
NISSDDSGKQISCVAENLVG NTRK2_HUMAN 254 142
NVSSMDSGLWISCVAENIVG NTRK2_CHICK 253 142
NVTSEDNGFTLTCIAENVVG NTRK3_PANTR 272 148
NVTSEDNGFTLTCIAENVVG NTRK3_MOUSE 272 148
NVTSDLNRKNVTCWAENDVG NTRK1_HUMAN 253 141
NTKRECEPTOR3 Length of motif = 18 Motif number = 3
Neurotrophic tyrosine kinase receptor family motif III - 1
PCODE ST INT
GCLQLDNPTHMNNGDYTL NTRK2_HUMAN 344 70
GCLQLDNPTHLNNGAYTL NTRK2_CHICK 343 70
GCLLFNKPTHYNNGNYTL NTRK3_PANTR 361 69
GCLLFNKPTHYNNGNYTL NTRK3_MOUSE 361 69
GCLRLNQPTHVNNGNYTL NTRK1_HUMAN 344 71
FINAL MOTIF SETS
NTKRECEPTOR1 Length of motif = 26 Motif number = 1
Neurotrophic tyrosine kinase receptor family motif I - 2
PCODE ST INT
DMELYTGLQKLTIKNSGLRSIQPRAF NTRK3_HUMAN 98 98
DMELYTGLQKLTIKNSGLRSIQPRAF Q96CY4_HUMAN 98 98
DMELYTGLQKLTIKNSGLRSIQPRAF NTRK3_SAIBB 98 98
DMELYTGLQKLTIKNSGLRSIQPRAF NTRK3_PIG 98 98
DMELYTGLQKLTIKNSGLRSIQPRAF NTRK3_PANTR 98 98
DMELYTGLQKLTIKNSGLRNIQPRAF A4QPD0_MOUSE 98 98
DMELYTGLQKLTIKNSGLRNIQPRAF Q68G04_RAT 98 98
DMELYTGLQKLTIKNSGLRNIQPRAF NTRK3_RAT 98 98
DMELYTGLQKLTIKNSGLRNIQPRAF NTRK3_MOUSE 98 98
DMELYTGLQKLTIRNSGLRSIQPRAF NTRK3_MACFA 98 98
DVEAYVGLRNLTIVDSGLKFVAHKAF NTRK2_HUMAN 86 86
DVEAYVGLRNLTIVDSGLKFVAHKAF Q8WXJ7_HUMAN 86 86
DVEAYVGLRNLTIVDSGLKFVAHKAF Q8WXJ5_HUMAN 86 86
DVEAYVGLRNLTIVDSGLKFVAHKAF Q5VWE5_HUMAN 86 86
DVEAYVGLRNLTIVDSGLKFVAHKAF Q548C2_HUMAN 86 86
DVEAYVGLRNLTIVDSGLKFVAYKAF NTRK2_MOUSE 86 86
DVEAYVGLRNLTIVDSGLKFVAYKAF Q3UHE3_MOUSE 86 86
DVEAYVGLKNLTIVDSGLKFVAYKAF NTRK2_RAT 86 86
DMELYTGLQRLTIRNSGLRNIQPRAF NTRK3_CHICK 98 98
DLEAYVGLKNLTIVDSGLKSVAHKAF Q0VCN4_BOVIN 86 86
DLRGLGELRNLTIVKSGLRFVAPDAF A6NF12_HUMAN 56 56
DLRGLGELRNLTIVKSGLRFVAPDAF NTRK1_HUMAN 86 86
DLRGLGELRNLTIVKSGLRFVAPDAF A8K3Z4_HUMAN 86 86
DVKIYTGLRNLTVVDSGLQIVSRQAF Q7ZXJ8_XENLA 85 85
DVKIYTGLRNLTVVDSGLQIVSRQAF Q9YH44_XENLA 85 85
DVKIYTGLRNLTVVDSGLQIVSRQAF Q9YH43_XENLA 85 85
DVKIYTGLRNLTVVDSGLQIVSRQAF Q08D53_XENTR 85 85
DLQGLGELRSLTIVKSGLRFVAPDAF NTRK1_MOUSE 86 86
DLQGLGELRSLTIVKSGLRFVAPDAF NTRK1_RAT 86 86
EVGFYVGLKNLTVVDSGLRFVSRQAF NTRK2_CHICK 85 85
DIKIYTGLRNLTVVDSGLQIVSRQAF Q5PPW7_XENLA 82 82
DTRMLWDLRHLTISNSGLQYISDDAF Q90699_CHICK 76 76
QLGHYKGLIKLVIKNSNLSTIEDGAF Q52V39_BRAFL 81 81
QLGHYKGLIKLVIKNSNLSTIEDGAF Q52V40_BRAFL 81 81
NTKRECEPTOR2 Length of motif = 20 Motif number = 2
Neurotrophic tyrosine kinase receptor family motif II - 2
PCODE ST INT
NVTSEDNGFTLTCIAENVVG NTRK3_HUMAN 272 148
NVTSEDNGFTLTCIAENVVG Q96CY4_HUMAN 272 148
NVTSEDNGFTLTCIAENVVG NTRK3_SAIBB 272 148
NVTSEDNGFTLTCIAENVVG NTRK3_PIG 272 148
NVTSEDNGFTLTCIAENVVG NTRK3_PANTR 272 148
NVTSEDNGFTLTCIAENVVG A4QPD0_MOUSE 272 148
NVTSEDNGFTLTCIAENVVG Q68G04_RAT 272 148
NVTSEDNGFTLTCIAENVVG NTRK3_RAT 272 148
NVTSEDNGFTLTCIAENVVG NTRK3_MOUSE 272 148
NVTSEDNGFTLTCIAENVVG NTRK3_MACFA 272 148
NISSDDSGKQISCVAENLVG NTRK2_HUMAN 254 142
NISSDDSGKQISCVAENLVG Q8WXJ7_HUMAN 254 142
NISSDDSGKQISCVAENLVG Q8WXJ5_HUMAN 254 142
NISSDDSGKQISCVAENLVG Q5VWE5_HUMAN 254 142
NISSDDSGKQISCVAENLVG Q548C2_HUMAN 254 142
NISSDDSGKQISCVAENLVG NTRK2_MOUSE 254 142
NISSDDSGKQISCVAENLVG Q3UHE3_MOUSE 254 142
NISSDDSGKQISCVAENLVG NTRK2_RAT 254 142
NVTSEDNGFLLTCIAENVVG NTRK3_CHICK 272 148
NISSDDSGKQISCVAENLVG Q0VCN4_BOVIN 254 142
NVTSDLNRKNVTCWAENDVG A6NF12_HUMAN 223 141
NVTSDLNRKNVTCWAENDVG NTRK1_HUMAN 253 141
NVTSDLNRKNVTCWAENDVG A8K3Z4_HUMAN 253 141
NVTSLDNKRIIVCVAENSVG Q7ZXJ8_XENLA 254 143
NVTSLDNKRIIVCVAENSVG Q9YH44_XENLA 254 143
NVTSLDNKRIIVCVAENSVG Q9YH43_XENLA 254 143
NVTSMDNKRVIVCVAENSVG Q08D53_XENTR 253 142
NVTSDLNKKNVTCWAENDVG NTRK1_MOUSE 255 143
NVTSDLNKKNVTCWAENDVG NTRK1_RAT 255 143
NVSSMDSGLWISCVAENIVG NTRK2_CHICK 253 142
NITSLDNKRVILCVAENSVG Q5PPW7_XENLA 251 143
NISSSLNHKDLTCRAENAVG Q90699_CHICK 245 143
HNASEDDNGNWTCIAKNMVG Q52V39_BRAFL 252 145
HNASEDDNGNWTCIAKNMVG Q52V40_BRAFL 252 145
NTKRECEPTOR3 Length of motif = 18 Motif number = 3
Neurotrophic tyrosine kinase receptor family motif III - 3
PCODE ST INT
GCLLFNKPTHYNNGNYTL NTRK3_HUMAN 361 69
GCLLFNKPTHYNNGNYTL Q96CY4_HUMAN 361 69
GCLLFNKPTHYNNGNYTL NTRK3_SAIBB 361 69
GCLLFNKPTHYNNGNYTL NTRK3_PIG 361 69
GCLLFNKPTHYNNGNYTL NTRK3_PANTR 361 69
GCLLFNKPTHYNNGNYTL A4QPD0_MOUSE 361 69
GCLLFNKPTHYNNGNYTL Q68G04_RAT 361 69
GCLLFNKPTHYNNGNYTL NTRK3_RAT 361 69
GCLLFNKPTHYNNGNYTL NTRK3_MOUSE 361 69
GCLLFNKPTHYNNGNYTL NTRK3_MACFA 361 69
GCLQLDNPTHMNNGDYTL NTRK2_HUMAN 344 70
GCLQLDNPTHMNNGDYTL Q8WXJ7_HUMAN 344 70
GCLQLDNPTHMNNGDYTL Q8WXJ5_HUMAN 344 70
GCLQLDNPTHMNNGDYTL Q5VWE5_HUMAN 344 70
GCLQLDNPTHMNNGDYTL Q548C2_HUMAN 344 70
GCLQLDNPTHMNNGDYTL NTRK2_MOUSE 344 70
GCLQLDNPTHMNNGDYTL Q3UHE3_MOUSE 344 70
GCLQLDNPTHMNNGDYTL NTRK2_RAT 344 70
GCLLFNKPTHYNNGNYTI NTRK3_CHICK 361 69
GCLQLDNPTHMNNGDYKL Q0VCN4_BOVIN 344 70
GCLRLNQPTHVNNGNYTL A6NF12_HUMAN 314 71
GCLRLNQPTHVNNGNYTL NTRK1_HUMAN 344 71
GCLRLNQPTHVNNGNYTL A8K3Z4_HUMAN 344 71
GCLQLDSPTHLNNGFYTL Q7ZXJ8_XENLA 346 72
GCLQLDSPTHLNNGFYTL Q9YH44_XENLA 346 72
GCLQLDSPTHLNNGFYTL Q9YH43_XENLA 346 72
GCLQLDSPTHLNNGFYTL Q08D53_XENTR 345 72
GCLRLNQPTHVNNGNYTL NTRK1_MOUSE 347 72
GCLRLNQPTHVNNGNYTL NTRK1_RAT 347 72
GCLQLDNPTHLNNGAYTL NTRK2_CHICK 343 70
GCLQLDSPTHLNNGFYTL Q5PPW7_XENLA 343 72
GCLQLNRPTHVNNGNYTL Q90699_CHICK 337 72
GCLKFEVPSHVDNGNYTL Q52V39_BRAFL 343 71
GCLKFEVPSHVDNGNYTL Q52V40_BRAFL 343 71
User query: Display/Full Code "NTKRECEPTOR"