WORKLIST ENTRIES (1):

NTKRECEPTOR View alignment      Neurotrophic tyrosine kinase receptor family signature
 Type of fingerprint: COMPOUND with 3  elements
Links:
   PRINTS; PR00109 TYRKINASE
   PRINTS; PR01940 NTKRECEPTOR1; PR01941 NTKRECEPTOR2; PR01942 NTKRECEPTOR3

 Creation date 03-APR-2008

   1. BOTHWELL, M.
   Functional interactions of neurotrophins and neurotrophin receptors.
   ANNU.REV.NEUROSCI. 18 223-253 (1995).

   2. HUANG, E. AND REICHARDT, L.
   Neurotrophins: roles in neuronal development and function.
   ANNU.REV.NEUROSCI. 24 677-736 (2001).

   Neurotrophins are a family of secreted proteins that regulate development, 
   maintenance and function of vertebrate nervous systems. They act via two 
   different classes of receptor: p75NTR (a member of the TNF receptor 
   superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also 
   known as tropomyosin-related kinases (Trks) [1]. 
  
   NTRKs are multi-domain, transmembrane proteins - in addition to their
   cytoplasmic kinase domains, members of the family possess a number of
   extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand
   binding induces them to dimerise, resulting in activation of their
   cytoplasmic tyrosine kinase domains. The activated receptors couple to a
   variety of intracellular signalling cascades, including the Ras,
   phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP)
   kinase, and phospholipase C (PLC)-gamma pathways [2].
  
   NTKRECEPTOR is a 3-element fingerprint that provides a signature for the
   neurotrophic tyrosine kinase receptor family. The fingerprint was derived
   from an initial alignment of 5 sequences: the motifs were drawn from
   conserved regions within the N-terminal extracellular domain - motif 1 spans
   the first LRR region; and motifs 2 and 3 lie within the first and second
   Ig-like C2-type domains, respectively. Two iterations on SPTR55_38f were
   required to reach convergence, at which point a true set comprising 34
   sequences was identified. A single partial match was also found,
   A8WGA3_DANRE, a translated mRNA sequence from zebrafish that fails to match
   motif 3.

  SUMMARY INFORMATION
     34 codes involving  3 elements
      1 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    3|  34   34   34  
    2|   1    1    0  
   --+----------------
     |   1    2    3  

True positives..
 NTRK3_HUMAN    Q96CY4_HUMAN   NTRK3_SAIBB    NTRK3_PIG      
 NTRK3_PANTR    A4QPD0_MOUSE   Q68G04_RAT     NTRK3_RAT      
 NTRK3_MOUSE    NTRK3_MACFA    NTRK2_HUMAN    Q8WXJ7_HUMAN   
 Q8WXJ5_HUMAN   Q5VWE5_HUMAN   Q548C2_HUMAN   NTRK2_MOUSE    
 Q3UHE3_MOUSE   NTRK2_RAT      NTRK3_CHICK    Q0VCN4_BOVIN   
 A6NF12_HUMAN   NTRK1_HUMAN    A8K3Z4_HUMAN   Q7ZXJ8_XENLA   
 Q9YH44_XENLA   Q9YH43_XENLA   Q08D53_XENTR   NTRK1_MOUSE    
 NTRK1_RAT      NTRK2_CHICK    Q5PPW7_XENLA   Q90699_CHICK   
 Q52V39_BRAFL   Q52V40_BRAFL   
Subfamily:  Codes involving 2 elements
 Subfamily True positives..
 A8WGA3_DANRE   


  PROTEIN TITLES
   NTRK3_HUMAN      NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
   Q96CY4_HUMAN     Neurotrophic tyrosine kinase, receptor, type 3 (Neurotrophic
   NTRK3_SAIBB      NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
   NTRK3_PIG        NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
   NTRK3_PANTR      NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
   A4QPD0_MOUSE     Neurotrophic tyrosine kinase, receptor, type 3 - Mus musculu
   Q68G04_RAT       Ntrk3 protein - Rattus norvegicus (Rat).
   NTRK3_RAT        NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
   NTRK3_MOUSE      NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
   NTRK3_MACFA      NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
   NTRK2_HUMAN      BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (N
   Q8WXJ7_HUMAN     Tyrosine-protein kinase receptor (EC 2.7.10.1) - Homo sapien
   Q8WXJ5_HUMAN     Neurotrophin receptor tyrosine kinase type 2 truncated isofo
   Q5VWE5_HUMAN     Neurotrophic tyrosine kinase, receptor, type 2 (Neurotrophic
   Q548C2_HUMAN     Neurotrophic tyrosine kinase receptor type 2 - Homo sapiens 
   NTRK2_MOUSE      BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (N
   Q3UHE3_MOUSE     CDNA, RIKEN full-length enriched library, clone:M5C1042H21 p
   NTRK2_RAT        BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (N
   NTRK3_CHICK      NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotr
   Q0VCN4_BOVIN     Neurotrophic tyrosine kinase, receptor, type 2 - Bos taurus 
   A6NF12_HUMAN     Tyrosine-protein kinase receptor (EC 2.7.10.1) - Homo sapien
   NTRK1_HUMAN      High affinity nerve growth factor receptor precursor (EC 2.7
   A8K3Z4_HUMAN     cDNA FLJ75372, highly similar to Human trk proto-oncogene in
   Q7ZXJ8_XENLA     Trkb-B-prov protein - Xenopus laevis (African clawed frog).
   Q9YH44_XENLA     Tyrosine-protein kinase receptor (EC 2.7.10.1) - Xenopus lae
   Q9YH43_XENLA     Tyrosine-protein kinase receptor (EC 2.7.10.1) - Xenopus lae
   Q08D53_XENTR     Tyrosine-protein kinase receptor (EC 2.7.10.1) - Xenopus tro
   NTRK1_MOUSE      High affinity nerve growth factor receptor precursor (EC 2.7
   NTRK1_RAT        High affinity nerve growth factor receptor precursor (EC 2.7
   NTRK2_CHICK      BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (N
   Q5PPW7_XENLA     Ntrk2 protein - Xenopus laevis (African clawed frog).
   Q90699_CHICK     Tyrosine-protein kinase receptor (EC 2.7.10.1) - Gallus gall
   Q52V39_BRAFL     Tyrosine-protein kinase receptor (EC 2.7.10.1) - Branchiosto
   Q52V40_BRAFL     Neurotrophic tyrosine kinase receptor precursor - Branchiost
 
   A8WGA3_DANRE     Putative uncharacterized protein - Danio rerio (Zebrafish) (

SCAN HISTORY SPTR55_38f 2 300 NSINGLE INITIAL MOTIF SETS NTKRECEPTOR1 Length of motif = 26 Motif number = 1 Neurotrophic tyrosine kinase receptor family motif I - 1 PCODE ST INT DVEAYVGLRNLTIVDSGLKFVAHKAF NTRK2_HUMAN 86 86 EVGFYVGLKNLTVVDSGLRFVSRQAF NTRK2_CHICK 85 85 DMELYTGLQKLTIKNSGLRSIQPRAF NTRK3_PANTR 98 98 DMELYTGLQKLTIKNSGLRNIQPRAF NTRK3_MOUSE 98 98 DLRGLGELRNLTIVKSGLRFVAPDAF NTRK1_HUMAN 86 86 NTKRECEPTOR2 Length of motif = 20 Motif number = 2 Neurotrophic tyrosine kinase receptor family motif II - 1 PCODE ST INT NISSDDSGKQISCVAENLVG NTRK2_HUMAN 254 142 NVSSMDSGLWISCVAENIVG NTRK2_CHICK 253 142 NVTSEDNGFTLTCIAENVVG NTRK3_PANTR 272 148 NVTSEDNGFTLTCIAENVVG NTRK3_MOUSE 272 148 NVTSDLNRKNVTCWAENDVG NTRK1_HUMAN 253 141 NTKRECEPTOR3 Length of motif = 18 Motif number = 3 Neurotrophic tyrosine kinase receptor family motif III - 1 PCODE ST INT GCLQLDNPTHMNNGDYTL NTRK2_HUMAN 344 70 GCLQLDNPTHLNNGAYTL NTRK2_CHICK 343 70 GCLLFNKPTHYNNGNYTL NTRK3_PANTR 361 69 GCLLFNKPTHYNNGNYTL NTRK3_MOUSE 361 69 GCLRLNQPTHVNNGNYTL NTRK1_HUMAN 344 71 FINAL MOTIF SETS NTKRECEPTOR1 Length of motif = 26 Motif number = 1 Neurotrophic tyrosine kinase receptor family motif I - 2 PCODE ST INT DMELYTGLQKLTIKNSGLRSIQPRAF NTRK3_HUMAN 98 98 DMELYTGLQKLTIKNSGLRSIQPRAF Q96CY4_HUMAN 98 98 DMELYTGLQKLTIKNSGLRSIQPRAF NTRK3_SAIBB 98 98 DMELYTGLQKLTIKNSGLRSIQPRAF NTRK3_PIG 98 98 DMELYTGLQKLTIKNSGLRSIQPRAF NTRK3_PANTR 98 98 DMELYTGLQKLTIKNSGLRNIQPRAF A4QPD0_MOUSE 98 98 DMELYTGLQKLTIKNSGLRNIQPRAF Q68G04_RAT 98 98 DMELYTGLQKLTIKNSGLRNIQPRAF NTRK3_RAT 98 98 DMELYTGLQKLTIKNSGLRNIQPRAF NTRK3_MOUSE 98 98 DMELYTGLQKLTIRNSGLRSIQPRAF NTRK3_MACFA 98 98 DVEAYVGLRNLTIVDSGLKFVAHKAF NTRK2_HUMAN 86 86 DVEAYVGLRNLTIVDSGLKFVAHKAF Q8WXJ7_HUMAN 86 86 DVEAYVGLRNLTIVDSGLKFVAHKAF Q8WXJ5_HUMAN 86 86 DVEAYVGLRNLTIVDSGLKFVAHKAF Q5VWE5_HUMAN 86 86 DVEAYVGLRNLTIVDSGLKFVAHKAF Q548C2_HUMAN 86 86 DVEAYVGLRNLTIVDSGLKFVAYKAF NTRK2_MOUSE 86 86 DVEAYVGLRNLTIVDSGLKFVAYKAF Q3UHE3_MOUSE 86 86 DVEAYVGLKNLTIVDSGLKFVAYKAF NTRK2_RAT 86 86 DMELYTGLQRLTIRNSGLRNIQPRAF NTRK3_CHICK 98 98 DLEAYVGLKNLTIVDSGLKSVAHKAF Q0VCN4_BOVIN 86 86 DLRGLGELRNLTIVKSGLRFVAPDAF A6NF12_HUMAN 56 56 DLRGLGELRNLTIVKSGLRFVAPDAF NTRK1_HUMAN 86 86 DLRGLGELRNLTIVKSGLRFVAPDAF A8K3Z4_HUMAN 86 86 DVKIYTGLRNLTVVDSGLQIVSRQAF Q7ZXJ8_XENLA 85 85 DVKIYTGLRNLTVVDSGLQIVSRQAF Q9YH44_XENLA 85 85 DVKIYTGLRNLTVVDSGLQIVSRQAF Q9YH43_XENLA 85 85 DVKIYTGLRNLTVVDSGLQIVSRQAF Q08D53_XENTR 85 85 DLQGLGELRSLTIVKSGLRFVAPDAF NTRK1_MOUSE 86 86 DLQGLGELRSLTIVKSGLRFVAPDAF NTRK1_RAT 86 86 EVGFYVGLKNLTVVDSGLRFVSRQAF NTRK2_CHICK 85 85 DIKIYTGLRNLTVVDSGLQIVSRQAF Q5PPW7_XENLA 82 82 DTRMLWDLRHLTISNSGLQYISDDAF Q90699_CHICK 76 76 QLGHYKGLIKLVIKNSNLSTIEDGAF Q52V39_BRAFL 81 81 QLGHYKGLIKLVIKNSNLSTIEDGAF Q52V40_BRAFL 81 81 NTKRECEPTOR2 Length of motif = 20 Motif number = 2 Neurotrophic tyrosine kinase receptor family motif II - 2 PCODE ST INT NVTSEDNGFTLTCIAENVVG NTRK3_HUMAN 272 148 NVTSEDNGFTLTCIAENVVG Q96CY4_HUMAN 272 148 NVTSEDNGFTLTCIAENVVG NTRK3_SAIBB 272 148 NVTSEDNGFTLTCIAENVVG NTRK3_PIG 272 148 NVTSEDNGFTLTCIAENVVG NTRK3_PANTR 272 148 NVTSEDNGFTLTCIAENVVG A4QPD0_MOUSE 272 148 NVTSEDNGFTLTCIAENVVG Q68G04_RAT 272 148 NVTSEDNGFTLTCIAENVVG NTRK3_RAT 272 148 NVTSEDNGFTLTCIAENVVG NTRK3_MOUSE 272 148 NVTSEDNGFTLTCIAENVVG NTRK3_MACFA 272 148 NISSDDSGKQISCVAENLVG NTRK2_HUMAN 254 142 NISSDDSGKQISCVAENLVG Q8WXJ7_HUMAN 254 142 NISSDDSGKQISCVAENLVG Q8WXJ5_HUMAN 254 142 NISSDDSGKQISCVAENLVG Q5VWE5_HUMAN 254 142 NISSDDSGKQISCVAENLVG Q548C2_HUMAN 254 142 NISSDDSGKQISCVAENLVG NTRK2_MOUSE 254 142 NISSDDSGKQISCVAENLVG Q3UHE3_MOUSE 254 142 NISSDDSGKQISCVAENLVG NTRK2_RAT 254 142 NVTSEDNGFLLTCIAENVVG NTRK3_CHICK 272 148 NISSDDSGKQISCVAENLVG Q0VCN4_BOVIN 254 142 NVTSDLNRKNVTCWAENDVG A6NF12_HUMAN 223 141 NVTSDLNRKNVTCWAENDVG NTRK1_HUMAN 253 141 NVTSDLNRKNVTCWAENDVG A8K3Z4_HUMAN 253 141 NVTSLDNKRIIVCVAENSVG Q7ZXJ8_XENLA 254 143 NVTSLDNKRIIVCVAENSVG Q9YH44_XENLA 254 143 NVTSLDNKRIIVCVAENSVG Q9YH43_XENLA 254 143 NVTSMDNKRVIVCVAENSVG Q08D53_XENTR 253 142 NVTSDLNKKNVTCWAENDVG NTRK1_MOUSE 255 143 NVTSDLNKKNVTCWAENDVG NTRK1_RAT 255 143 NVSSMDSGLWISCVAENIVG NTRK2_CHICK 253 142 NITSLDNKRVILCVAENSVG Q5PPW7_XENLA 251 143 NISSSLNHKDLTCRAENAVG Q90699_CHICK 245 143 HNASEDDNGNWTCIAKNMVG Q52V39_BRAFL 252 145 HNASEDDNGNWTCIAKNMVG Q52V40_BRAFL 252 145 NTKRECEPTOR3 Length of motif = 18 Motif number = 3 Neurotrophic tyrosine kinase receptor family motif III - 3 PCODE ST INT GCLLFNKPTHYNNGNYTL NTRK3_HUMAN 361 69 GCLLFNKPTHYNNGNYTL Q96CY4_HUMAN 361 69 GCLLFNKPTHYNNGNYTL NTRK3_SAIBB 361 69 GCLLFNKPTHYNNGNYTL NTRK3_PIG 361 69 GCLLFNKPTHYNNGNYTL NTRK3_PANTR 361 69 GCLLFNKPTHYNNGNYTL A4QPD0_MOUSE 361 69 GCLLFNKPTHYNNGNYTL Q68G04_RAT 361 69 GCLLFNKPTHYNNGNYTL NTRK3_RAT 361 69 GCLLFNKPTHYNNGNYTL NTRK3_MOUSE 361 69 GCLLFNKPTHYNNGNYTL NTRK3_MACFA 361 69 GCLQLDNPTHMNNGDYTL NTRK2_HUMAN 344 70 GCLQLDNPTHMNNGDYTL Q8WXJ7_HUMAN 344 70 GCLQLDNPTHMNNGDYTL Q8WXJ5_HUMAN 344 70 GCLQLDNPTHMNNGDYTL Q5VWE5_HUMAN 344 70 GCLQLDNPTHMNNGDYTL Q548C2_HUMAN 344 70 GCLQLDNPTHMNNGDYTL NTRK2_MOUSE 344 70 GCLQLDNPTHMNNGDYTL Q3UHE3_MOUSE 344 70 GCLQLDNPTHMNNGDYTL NTRK2_RAT 344 70 GCLLFNKPTHYNNGNYTI NTRK3_CHICK 361 69 GCLQLDNPTHMNNGDYKL Q0VCN4_BOVIN 344 70 GCLRLNQPTHVNNGNYTL A6NF12_HUMAN 314 71 GCLRLNQPTHVNNGNYTL NTRK1_HUMAN 344 71 GCLRLNQPTHVNNGNYTL A8K3Z4_HUMAN 344 71 GCLQLDSPTHLNNGFYTL Q7ZXJ8_XENLA 346 72 GCLQLDSPTHLNNGFYTL Q9YH44_XENLA 346 72 GCLQLDSPTHLNNGFYTL Q9YH43_XENLA 346 72 GCLQLDSPTHLNNGFYTL Q08D53_XENTR 345 72 GCLRLNQPTHVNNGNYTL NTRK1_MOUSE 347 72 GCLRLNQPTHVNNGNYTL NTRK1_RAT 347 72 GCLQLDNPTHLNNGAYTL NTRK2_CHICK 343 70 GCLQLDSPTHLNNGFYTL Q5PPW7_XENLA 343 72 GCLQLNRPTHVNNGNYTL Q90699_CHICK 337 72 GCLKFEVPSHVDNGNYTL Q52V39_BRAFL 343 71 GCLKFEVPSHVDNGNYTL Q52V40_BRAFL 343 71

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