WORKLIST ENTRIES (1):
NEUROKININR View alignment View Structure Neurokinin receptor signature
Type of fingerprint: COMPOUND with 8 elements
Links:
PRINTS; PR00237 GPCRRHODOPSN; PR00247 GPCRCAMP; PR00248 GPCRMGR
PRINTS; PR00249 GPCRSECRETIN; PR00250 GPCRSTE2; PR00899 GPCRSTE3
PRINTS; PR00251 BACTRLOPSIN
PRINTS; PR01024 NEUROKININ1R; PR01025 NEUROKININ2R; PR01026 NEUROKININ3R
INTERPRO; IPR001681
Creation date 14-JUL-1994; UPDATE 03-JUL-1999
1. ATTWOOD, T.K. AND FINDLAY, J.B.C.
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994).
2. ATTWOOD, T.K. AND FINDLAY, J.B.C.
G protein-coupled receptor fingerprints.
7TM, VOLUME 2, EDS. G.VRIEND AND B.BYWATER (1993).
3. BIRNBAUMER, L.
G proteins in signal transduction.
ANNU.REV.PHARMACOL.TOXICOL. 30 675-705 (1990).
4. CASEY, P.J. AND GILMAN, A.G.
G protein involvement in receptor-effector coupling.
J.BIOL.CHEM. 263(6) 2577-2580 (1988).
5. ATTWOOD, T.K. AND FINDLAY, J.B.C.
Design of a discriminating fingerprint for G protein-coupled receptors.
PROTEIN ENG. 6(2) 167-176 (1993).
6. YOKOTA, Y., SASAI, Y., TANAKA, K., FUJIWARA, T, TSUCHIDA, K.,
SHIGEMOTO, R., KAKIZUKA, A., OHKUBO, H. AND NAKANISHI, S.
Molecular characterisation of a functional cDNA for rat substance P
receptor.
J.BIOL.CHEM. 264(30) 17649-17652 (1989).
G protein-coupled receptors (GPCRs) constitute a vast protein family that
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the
sequence level, on the basis of which they can be separated into distinct
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship,
but between which there is no statistically significant similarity in
sequence [1,2]. The currently known clan members include the rhodopsin-like
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
The rhodopsin-like GPCRs themselves represent a widespread protein family
that includes hormone, neurotransmitter and light receptors, all of
which transduce extracellular signals through interaction with guanine
nucleotide-binding (G) proteins. Although their activating ligands vary
widely in structure and character, the amino acid sequences of the
receptors are very similar and are believed to adopt a common structural
framework comprising 7 transmembrane (TM) helices [3-5].
Neuropeptide receptors are present in very small quantities in the cell
and are embedded tightly in the plasma membrane. The neuropeptides exhibit
a high degree of functional diversity through both regulation of peptide
production and through peptide-receptor interaction [6]. The mammalian
tachykinin system consists of 3 distinct peptides: substance P, substance
K and neuromedin K. All possess a common spectrum of biological activities,
including sensory transmission in the nervous system and contraction/
relaxation of peripheral smooth muscles, and each interacts with a
specific receptor type.
NEUROKININR is an 8-element fingerprint that provides a signature for the
neurokinin receptors. The fingerprint was derived from an initial alignment
of 6 sequences: the motifs were drawn from conserved sections within either
loop or TM regions, focusing on those areas of the alignment that
characterise the neurokinin receptors but distinguish them from the
rest of the rhodopsin-like superfamily - motif 1 lies at the N-terminus
leading into TM domain 1; motif 2 spans the C-terminus of TM domain 1 and
part of the first cytoplasmic loop; motif 3 spans part of the first
external loop leading into TM domain 3; motif 4 lies in the second
cytoplasmic loop; motif 5 lies at the N-terminus of TM domain 5; motif 6
spans the C-terminus of TM domain 5 leading into the third cytoplasmic
loop; motif 7 spans part of the third external loop leading into TM domain
7; and motif 8 lies at the C-terminus. Two iterations on OWL23.2 were
required to reach convergence, at which point a true set comprising 16
sequences was identified. Several partial matches were also found, all
of which are neurokinin receptor fragments or close superfamily relatives.
An update on SPTR37_9f identified a true set of 15 sequences, and 5
partial matches.
SUMMARY INFORMATION
15 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
1 codes involving 5 elements
0 codes involving 4 elements
1 codes involving 3 elements
3 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
8| 15 15 15 15 15 15 15 15
7| 0 0 0 0 0 0 0 0
6| 0 0 0 0 0 0 0 0
5| 1 1 0 0 0 1 1 1
4| 0 0 0 0 0 0 0 0
3| 0 0 0 0 0 1 1 1
2| 1 2 0 1 0 0 0 2
--+-----------------------------------------
| 1 2 3 4 5 6 7 8
True positives..
NK3R_RAT NK3R_HUMAN NK1R_RAT NK1R_MOUSE
NK1R_HUMAN NK1R_CAVPO NK2R_HUMAN NK2R_RAT
NK2R_CAVPO NK2R_MESAU NK2R_MOUSE NK2R_BOVIN
NK4R_HUMAN NK2R_RABIT NK1R_RANCA
Subfamily: Codes involving 5 elements
Subfamily True positives..
Q94736
Subfamily: Codes involving 3 elements
Subfamily True positives..
TLR2_DROME
Subfamily: Codes involving 2 elements
Subfamily True positives..
O44148 YLD1_CAEEL
PROTEIN TITLES
NK3R_RAT NEUROMEDIN K RECEPTOR (NKR) (NEUROKININ B RECEPTOR) (NK-3 RE
NK3R_HUMAN NEUROMEDIN K RECEPTOR (NKR) (NEUROKININ B RECEPTOR) (NK-3 RE
NK1R_RAT SUBSTANCE-P RECEPTOR (SPR) (NK-1 RECEPTOR) (NK-1R) - RATTUS
NK1R_MOUSE SUBSTANCE-P RECEPTOR (SPR) (NK-1 RECEPTOR) (NK-1R) - MUS MUS
NK1R_HUMAN SUBSTANCE-P RECEPTOR (SPR) (NK-1 RECEPTOR) (NK-1R) - HOMO SA
NK1R_CAVPO SUBSTANCE-P RECEPTOR (SPR) (NK-1 RECEPTOR) (NK-1R) - CAVIA P
NK2R_HUMAN SUBSTANCE-K RECEPTOR (SKR) (NEUROKININ A RECEPTOR) (NK-2 REC
NK2R_RAT SUBSTANCE-K RECEPTOR (SKR) (NEUROKININ A RECEPTOR) (NK-2 REC
NK2R_CAVPO SUBSTANCE-K RECEPTOR (SKR) (NEUROKININ A RECEPTOR) (NK-2 REC
NK2R_MESAU SUBSTANCE-K RECEPTOR (SKR) (NEUROKININ A RECEPTOR) (NK-2 REC
NK2R_MOUSE SUBSTANCE-K RECEPTOR (SKR) (NEUROKININ A RECEPTOR) (NK-2 REC
NK2R_BOVIN SUBSTANCE-K RECEPTOR (SKR) (NEUROKININ A RECEPTOR) (NK-2 REC
NK4R_HUMAN NEUROMEDIN K RECEPTOR (NKR) (NEUROKININ B RECEPTOR) (NK-4 RE
NK2R_RABIT SUBSTANCE-K RECEPTOR (SKR) (NEUROKININ A RECEPTOR) (NK-2 REC
NK1R_RANCA SUBSTANCE-P RECEPTOR (SPR) (NK-1 RECEPTOR) (NK-1R) - RANA CA
Q94736 TACHYKININ-LIKE RECEPTOR - STOMOXYS CALCITRANS (STABLE FLY).
TLR2_DROME TACHYKININ-LIKE PEPTIDES RECEPTOR 99D (DTKR) - DROSOPHILA ME
O44148 C49A9.7 PROTEIN - CAENORHABDITIS ELEGANS.
YLD1_CAEEL PROBABLE G PROTEIN-COUPLED RECEPTOR C38C10.1 - CAENORHABDITI
SCAN HISTORY
OWL30_2 4 100 NSINGLE
SPTR37_9f 1 100 NSINGLE
INITIAL MOTIF SETS
NEUROKININR1 Length of motif = 12 Motif number = 1
Neurokinin receptor motif I - 1
PCODE ST INT
PAWQIVLWAAAY NK1R_CAVPO 28 28
PAWQIVLWAAAY NK1R_HUMAN 28 28
PSWQLALWAPAY NK2R_HUMAN 29 29
PGWQLALWATAY NK2R_MOUSE 29 29
PSWRIALWSLAY NK3R_HUMAN 81 81
PSWRIALWSLAY NK3R_RAT 68 68
NEUROKININR2 Length of motif = 10 Motif number = 2
Neurokinin receptor motif II - 1
PCODE ST INT
MWIILAHKRM NK1R_CAVPO 54 14
MWIILAHKRM NK1R_HUMAN 54 14
IWIILAHRRM NK2R_HUMAN 55 14
IWIILAHERM NK2R_MOUSE 55 14
IWIILAHKRM NK3R_HUMAN 107 14
IWIILAHKRM NK3R_RAT 94 14
NEUROKININR3 Length of motif = 11 Motif number = 3
Neurokinin receptor motif III - 1
PCODE ST INT
FHNFFPIAAVF NK1R_CAVPO 107 43
FHNFFPIAAVF NK1R_HUMAN 107 43
FQNLFPITAMF NK2R_HUMAN 108 43
FQNLFPVTAMF NK2R_MOUSE 108 43
FQNFFPITAVF NK3R_HUMAN 160 43
FQNFFPITAVF NK3R_RAT 147 43
NEUROKININR4 Length of motif = 11 Motif number = 4
Neurokinin receptor motif IV - 1
PCODE ST INT
LQPRLSATATK NK1R_CAVPO 138 20
LQPRLSATATK NK1R_HUMAN 138 20
FQPRLSAPSTK NK2R_HUMAN 139 20
FQPRLSAPSTK NK2R_MOUSE 139 20
LKPRLSATATK NK3R_HUMAN 191 20
LKPRLSATATK NK3R_RAT 178 20
NEUROKININR5 Length of motif = 10 Motif number = 5
Neurokinin receptor motif V - 1
PCODE ST INT
YHICVTVLIY NK1R_CAVPO 196 47
YHICVTVLIY NK1R_HUMAN 196 47
YHLVVIALIY NK2R_HUMAN 197 47
YHLVVFVLIY NK2R_MOUSE 197 47
YHIIVIILVY NK3R_HUMAN 247 45
YHIIVIILVY NK3R_RAT 234 45
NEUROKININR6 Length of motif = 14 Motif number = 6
Neurokinin receptor motif VI - 1
PCODE ST INT
TVVGITLWASEIPG NK1R_CAVPO 217 11
TVVGITLWASEIPG NK1R_HUMAN 217 11
SVIGLTLWRRAVPG NK2R_HUMAN 218 11
SVIGLTLWKRAVPR NK2R_MOUSE 218 11
TIVGITLWGGEIPG NK3R_HUMAN 268 11
TIVGITLWGGEIPG NK3R_RAT 255 11
NEUROKININR7 Length of motif = 12 Motif number = 7
Neurokinin receptor motif VII - 1
PCODE ST INT
KKFIQQVYLAIM NK1R_CAVPO 280 49
KKFIQQVYLAIM NK1R_HUMAN 280 49
HKFIQQVYLALF NK2R_HUMAN 282 50
RKFIQQVYLALF NK2R_MOUSE 282 50
WKYIQQVYLASF NK3R_HUMAN 331 49
WKYIQQVYLASF NK3R_RAT 318 49
NEUROKININR8 Length of motif = 19 Motif number = 8
Neurokinin receptor motif VIII - 1
PCODE ST INT
CCLNDRFRLGFKHAFRCCP NK1R_CAVPO 306 14
CCLNDRFRLGFKHAFRCCP NK1R_HUMAN 306 14
CCLNHRFRSGFRLAFRCCP NK2R_HUMAN 308 14
CCLNHRFRSGFRLAFRCCP NK2R_MOUSE 308 14
CCLNKRFRAGFKRAFRWCP NK3R_HUMAN 357 14
CCLNKRFRAGFKRAFRWCP NK3R_RAT 344 14
FINAL MOTIF SETS
NEUROKININR1 Length of motif = 12 Motif number = 1
Neurokinin receptor motif I - 1
PCODE ST INT
PSWRIALWSLAY NK3R_RAT 68 68
PSWRIALWSLAY NK3R_HUMAN 81 81
PTWQIVLWAAAY NK1R_RAT 28 28
PTWQIVLWAAAY NK1R_MOUSE 28 28
PAWQIVLWAAAY NK1R_HUMAN 28 28
PAWQIVLWAAAY NK1R_CAVPO 28 28
PSWQLALWAPAY NK2R_HUMAN 29 29
PGWQLALWATAY NK2R_RAT 29 29
PTWQLALWATAY NK2R_CAVPO 29 29
PAWQLALWATAY NK2R_MESAU 29 29
PGWQLALWATAY NK2R_MOUSE 29 29
PGWQLALWTAAY NK2R_BOVIN 29 29
PPWAVALWSLAY NK4R_HUMAN 56 56
PGWQLALWATAY NK2R_RABIT 29 29
PPWQIALWSVAY NK1R_RANCA 29 29
NEUROKININR2 Length of motif = 10 Motif number = 2
Neurokinin receptor motif II - 1
PCODE ST INT
IWIILAHKRM NK3R_RAT 94 14
IWIILAHKRM NK3R_HUMAN 107 14
IWIILAHKRM NK1R_RAT 54 14
IWIILAHKRM NK1R_MOUSE 54 14
MWIILAHKRM NK1R_HUMAN 54 14
MWIILAHKRM NK1R_CAVPO 54 14
IWIILAHRRM NK2R_HUMAN 55 14
IWIILAHERM NK2R_RAT 55 14
TWIILAHQRM NK2R_CAVPO 55 14
IWIILAHERM NK2R_MESAU 55 14
IWIILAHERM NK2R_MOUSE 55 14
IWIILAHQRM NK2R_BOVIN 55 14
IWIVLAHKRM NK4R_HUMAN 82 14
IWIILAHRRM NK2R_RABIT 55 14
MWIIIAHKRM NK1R_RANCA 55 14
NEUROKININR3 Length of motif = 11 Motif number = 3
Neurokinin receptor motif III - 1
PCODE ST INT
FQNFFPITAVF NK3R_RAT 147 43
FQNFFPITAVF NK3R_HUMAN 160 43
FHNFFPIAALF NK1R_RAT 107 43
FHNFFPIAALF NK1R_MOUSE 107 43
FHNFFPIAAVF NK1R_HUMAN 107 43
FHNFFPIAAVF NK1R_CAVPO 107 43
FQNLFPITAMF NK2R_HUMAN 108 43
FQNLFPITAMF NK2R_RAT 108 43
FQNLFPITAMF NK2R_CAVPO 108 43
FQNLFPITAMF NK2R_MESAU 108 43
FQNLFPVTAMF NK2R_MOUSE 108 43
FQNLFPITAMF NK2R_BOVIN 108 43
FQNFFPITAVF NK4R_HUMAN 135 43
FQNLFPITAMF NK2R_RABIT 108 43
FHNFFPISAVF NK1R_RANCA 108 43
NEUROKININR4 Length of motif = 11 Motif number = 4
Neurokinin receptor motif IV - 1
PCODE ST INT
LKPRLSATATK NK3R_RAT 178 20
LKPRLSATATK NK3R_HUMAN 191 20
LQPRLSATATK NK1R_RAT 138 20
LQPRLSATATK NK1R_MOUSE 138 20
LQPRLSATATK NK1R_HUMAN 138 20
LQPRLSATATK NK1R_CAVPO 138 20
FQPRLSAPSTK NK2R_HUMAN 139 20
FQPRLSAPSTK NK2R_RAT 139 20
FQPRLSAPSTK NK2R_CAVPO 139 20
FQPRLSAPITK NK2R_MESAU 139 20
FQPRLSAPSTK NK2R_MOUSE 139 20
FQPRLSAPGTR NK2R_BOVIN 139 20
LKPRLSATATR NK4R_HUMAN 166 20
FQPRLSGPGTK NK2R_RABIT 139 20
LKPRLSATATK NK1R_RANCA 139 20
NEUROKININR5 Length of motif = 10 Motif number = 5
Neurokinin receptor motif V - 1
PCODE ST INT
YHIIVIILVY NK3R_RAT 234 45
YHIIVIILVY NK3R_HUMAN 247 45
YHICVTVLIY NK1R_RAT 196 47
YHICVTVLIY NK1R_MOUSE 196 47
YHICVTVLIY NK1R_HUMAN 196 47
YHICVTVLIY NK1R_CAVPO 196 47
YHLVVIALIY NK2R_HUMAN 197 47
YHLVVFVLIY NK2R_RAT 197 47
YHLVVIVLIY NK2R_CAVPO 197 47
YHLVVFVLVY NK2R_MESAU 197 47
YHLVVFVLIY NK2R_MOUSE 197 47
YHLIVIALIY NK2R_BOVIN 197 47
YHMIVIVLVY NK4R_HUMAN 222 45
YHLTVIALIY NK2R_RABIT 197 47
YQVLVFCLIY NK1R_RANCA 198 48
NEUROKININR6 Length of motif = 14 Motif number = 6
Neurokinin receptor motif VI - 1
PCODE ST INT
TIVGITLWGGEIPG NK3R_RAT 255 11
TIVGITLWGGEIPG NK3R_HUMAN 268 11
TVVGITLWASEIPG NK1R_RAT 217 11
TVVGITLWASEIPG NK1R_MOUSE 217 11
TVVGITLWASEIPG NK1R_HUMAN 217 11
TVVGITLWASEIPG NK1R_CAVPO 217 11
SVIGLTLWRRAVPG NK2R_HUMAN 218 11
SVIGLTLWKRAVPR NK2R_RAT 218 11
SIIGLTLWRRAVPR NK2R_CAVPO 218 11
SVIGLTLWKRAVPR NK2R_MESAU 218 11
SVIGLTLWKRAVPR NK2R_MOUSE 218 11
SVIGLTLWRRSVPG NK2R_BOVIN 218 11
TIVGITLWGGEIPG NK4R_HUMAN 243 11
SVIGFKLWRRTVPG NK2R_RABIT 218 11
TFIGMTLWASEIPG NK1R_RANCA 219 11
NEUROKININR7 Length of motif = 12 Motif number = 7
Neurokinin receptor motif VII - 1
PCODE ST INT
WKYIQQVYLASF NK3R_RAT 318 49
WKYIQQVYLASF NK3R_HUMAN 331 49
KKFIQQVYLASM NK1R_RAT 280 49
KKFIQQVYLASM NK1R_MOUSE 280 49
KKFIQQVYLAIM NK1R_HUMAN 280 49
KKFIQQVYLAIM NK1R_CAVPO 280 49
HKFIQQVYLALF NK2R_HUMAN 282 50
HKFIQQVYLALF NK2R_RAT 282 50
HKFIQQVYLALF NK2R_CAVPO 282 50
RKFIQQVYLALF NK2R_MESAU 282 50
RKFIQQVYLALF NK2R_MOUSE 282 50
HKFIQQVYLALF NK2R_BOVIN 282 50
WKYIQQVYLASF NK4R_HUMAN 306 49
RKFIQQVYLVLF NK2R_RABIT 282 50
QKFYQQFYLAIM NK1R_RANCA 280 47
NEUROKININR8 Length of motif = 19 Motif number = 8
Neurokinin receptor motif VIII - 1
PCODE ST INT
CCLNKRFRAGFKRAFRWCP NK3R_RAT 344 14
CCLNKRFRAGFKRAFRWCP NK3R_HUMAN 357 14
CCLNDRFRLGFKHAFRCCP NK1R_RAT 306 14
CCLNDRFRLGFKHAFRCCP NK1R_MOUSE 306 14
CCLNDRFRLGFKHAFRCCP NK1R_HUMAN 306 14
CCLNDRFRLGFKHAFRCCP NK1R_CAVPO 306 14
CCLNHRFRSGFRLAFRCCP NK2R_HUMAN 308 14
CCLNHRFRSGFRLAFRCCP NK2R_RAT 308 14
CCLNRRFRSGFRLAFRCCP NK2R_CAVPO 308 14
CCLNHRFRSGFRLAFRCCP NK2R_MESAU 308 14
CCLNHRFRSGFRLAFRCCP NK2R_MOUSE 308 14
CCLNHRFRSGFRLAFRCCP NK2R_BOVIN 308 14
CCLNKRFRAGFKRAFRWCP NK4R_HUMAN 332 14
CCLNHRFRSGFRLAFRCCP NK2R_RABIT 308 14
CCLNDRFRIGFKHVFRWCP NK1R_RANCA 306 14
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