WORKLIST ENTRIES (1):
MELIBIASE View alignment Melibiase signature
Type of fingerprint: COMPOUND with 8 elements
Links:
PRINTS; PR00131 GLHYDRLASE1; PR00132 GLHYDRLASE2; PR00133 GLHYDRLASE3
PRINTS; PR00732 GLHYDRLASE4; PR00733 GLHYDRLASE6; PR00734 GLHYDRLASE7
PRINTS; PR00735 GLHYDRLASE8; PR00134 GLHYDRLASE10; PR00911 GLHYDRLASE11
PRINTS; PR00736 GLHYDRLASE15; PR00737 GLHYDRLASE16; PR00738 GLHYDRLASE20
PRINTS; PR00739 GLHYDRLASE26; PR00740 GLHYDRLASE27; PR00741 GLHYDRLASE29
PRINTS; PR00843 GLHYDRLASE30; PR00742 GLHYDRLASE35; PR00743 GLHYDRLASE36
PRINTS; PR00744 GLHYDRLASE37; PR00745 GLHYDRLASE39; PR00746 GLHYDRLASE41
PRINTS; PR00747 GLHYDRLASE47; PR00844 GLHYDRLASE48; PR00845 GLHYDRLASE52
PRINTS; PR00846 GLHYDRLASE56; PR00849 GLHYDRLASE58; PR00850 GLHYDRLASE59
PRINTS; PR00137 LYSOZYME; PR00684 T4LYSOZYME; PR00749 LYSOZYMEG
PRINTS; PR00110 ALPHAAMYLASE; PR00750 BETAAMYLASE
INTERPRO; IPR002287
PROSITE; PS00512 ALPHA_GALACTOSIDASE
Creation date 11-JUN-1997; UPDATE 07-JUN-1999
1. HENRISSAT, B. AND BAIROCH, A.
New families in the classification of glycosyl hydrolases based on amino
acid sequence similarities.
BIOCHEM.J. 293 781-788 (1993).
2. HENRISSAT, B.
A classification of glycosyl hydrolases based on amino acid sequence
similarities.
BIOCHEM.J. 280 309-316 (1991).
3. DAVIES, G. AND HENRISSAT, B.
Structures and mechanisms of glycosyl hydrolases.
STRUCTURE 3 853-859 (1995).
4. HENRISSAT, B. AND BAIROCH, A.
Updating the sequence-based classification of glycosyl hydrolases.
BIOCHEM.J. 316 695-696 (1996).
5. TURAKAINEN, H., KRISTO, P. AND KORHOLA, M.
Consideration of the evolution of the Saccharomyces cerevisiae MEL gene
family on the basis of the nucleotide sequences of the genes and their
flanking regions.
YEAST 10(12) 1559-1568 (1994).
O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that
hydrolyse the glycosidic bond between two or more carbohydrates, or between
a carbohydrate and a non-carbohydrate moiety. A classification system for
glycosyl hydrolases, based on sequence similarity, has led to the definition
of up to 60 different families [1-4] (http://expasy.hcuge.ch/cgi-bin/lists?
glycosid.txt). Family 27 encompasses alpha-galactosidases (melibiase) and
alpha-N-acetylgalactosaminidases.
Melibiase catalyses the hydrolysis of melibiose into galactose and glucose
[5]. In man, deficiency in the enzyme results in Fabry's disease (X-linked
sphingolipidosis).
MELIBIASE is an 8-element fingerprint that provides a signature for
melibiases. The fingerprint was derived from an initial alignment of 4
sequences: the motifs were drawn from conserved regions spanning the
central and C-terminal portions of the alignment. Two iterations on OWL29.3
were required to reach convergence, at which point a true set comprising 8
sequences was identified. A single partial match was also found, S79400, a
related sequence that matches only motifs 1 and 4.
An update on SPTR37_9f identified a true set of 8 sequences.
SUMMARY INFORMATION
8 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
8| 8 8 8 8 8 8 8 8
7| 0 0 0 0 0 0 0 0
6| 0 0 0 0 0 0 0 0
5| 0 0 0 0 0 0 0 0
4| 0 0 0 0 0 0 0 0
3| 0 0 0 0 0 0 0 0
2| 0 0 0 0 0 0 0 0
--+-----------------------------------------
| 1 2 3 4 5 6 7 8
True positives..
MEL2_YEAST MEL5_YEAST MEL6_YEAST MEL1_YEAST
Q11129 Q09187 Q03647 Q99172
PROTEIN TITLES
MEL2_YEAST ALPHA-GALACTOSIDASE 2 PRECURSOR (EC 3.2.1.22) (MELIBIASE 2)
MEL5_YEAST ALPHA-GALACTOSIDASE 5 PRECURSOR (EC 3.2.1.22) (MELIBIASE 5)
MEL6_YEAST ALPHA-GALACTOSIDASE 6 PRECURSOR (EC 3.2.1.22) (MELIBIASE 6)
MEL1_YEAST ALPHA-GALACTOSIDASE 1 PRECURSOR (EC 3.2.1.22) (MELIBIASE 1)
Q11129 ALPHA-GALACTOSIDASE MEL GENE - SACCHAROMYCES SP.
Q09187 ALPHA-GALACTOSIDASE MEL GENE - SACCHAROMYCES PARADOXUS (YEAS
Q03647 ALPHA-GALACTOSIDASE PRECURSOR (EC 3.2.1.22) (MELIBIASE) (ALP
Q99172 ALPHA-GALACTOSIDASE - ZYGOSACCHAROMYCES CIDRI.
SCAN HISTORY
OWL29_3 2 100 NSINGLE
SPTR37_9f 2 9 NSINGLE
INITIAL MOTIF SETS
MELIBIASE1 Length of motif = 16 Motif number = 1
Melibiase motif I - 1
PCODE ST INT
NCYNKGQFGTPEISYH MEL1_YEAST 150 150
NCYNKGQFGTPEISYH MEL2_YEAST 150 150
NCYNKGQFGTPDVSYH MEL5_YEAST 150 150
NCYNKGQFGTPDVSYH MEL6_YEAST 150 150
MELIBIASE2 Length of motif = 20 Motif number = 2
Melibiase motif II - 1
PCODE ST INT
EFTRPDSRCPCDGDEYDCKY MEL1_YEAST 213 47
EFTRPDSRCPCDGDEYDCKY MEL2_YEAST 213 47
EFTRPDSRCPCDGDEYDCKY MEL5_YEAST 213 47
EFTRPDSRCPCDGDEYDCKY MEL6_YEAST 213 47
MELIBIASE3 Length of motif = 17 Motif number = 3
Melibiase motif III - 1
PCODE ST INT
RVWRYYVSDTDEYGQGE MEL1_YEAST 326 93
RVWRYYVSDTDEYGQGE MEL2_YEAST 326 93
RVWRYYVSDTDEYGQGE MEL5_YEAST 326 93
RVWRYYVSDTDEYGQGE MEL6_YEAST 326 93
MELIBIASE4 Length of motif = 17 Motif number = 4
Melibiase motif IV - 1
PCODE ST INT
DNGDQVVALLNGGSVSR MEL1_YEAST 351 8
DNGDQVVALLNGGSVPR MEL2_YEAST 351 8
DNGDQVVALLNGGSVAR MEL5_YEAST 351 8
DNGDQVVALLNGGSVAR MEL6_YEAST 351 8
MELIBIASE5 Length of motif = 24 Motif number = 5
Melibiase motif V - 1
PCODE ST INT
EEIFFDSNLGSKKLTSTWDIYDLW MEL1_YEAST 374 6
EEIFFDSNLGSKELTSTWDIYDLW MEL2_YEAST 374 6
EEIFFDSNLGSKELTSTWDIYDLW MEL5_YEAST 374 6
EEIFFDSNLGSKELTSTWDIYDLW MEL6_YEAST 374 6
MELIBIASE6 Length of motif = 23 Motif number = 6
Melibiase motif VI - 1
PCODE ST INT
RVDNSTASAILGRNKTATGILYN MEL1_YEAST 400 2
RVDNSTASAILGQNKTATGILYN MEL2_YEAST 400 2
RVDNSTASAILEQNKAATGILYN MEL5_YEAST 400 2
RVDNSTASAILEQNKAATGILYN MEL6_YEAST 400 2
MELIBIASE7 Length of motif = 17 Motif number = 7
Melibiase motif VII - 1
PCODE ST INT
YKDGLSKNDTRLFGQKI MEL1_YEAST 428 5
YKDGLSKNDTRLFGQKI MEL2_YEAST 428 5
YKDGLSKNDTRLFGQKI MEL5_YEAST 428 5
YKDGLSKNDTRLFGQKI MEL6_YEAST 428 5
MELIBIASE8 Length of motif = 21 Motif number = 8
Melibiase motif VIII - 1
PCODE ST INT
PNAILNTTVPAHGIAFYRLRP MEL1_YEAST 449 4
PNAILNTTVPAHGIAFYRLRP MEL2_YEAST 449 4
PNAILNTTVPAHGIAFYRLRP MEL5_YEAST 449 4
PNAILNTTVPAHGIAFYRLRP MEL6_YEAST 449 4
FINAL MOTIF SETS
MELIBIASE1 Length of motif = 16 Motif number = 1
Melibiase motif I - 2
PCODE ST INT
NCYNKGQFGTPEISYH MEL2_YEAST 150 150
NCYNKGQFGTPDVSYH MEL5_YEAST 150 150
NCYNKGQFGTPDVSYH MEL6_YEAST 150 150
NCYNKGQFGTPEISYH MEL1_YEAST 150 150
NCYNKGKFGTPETSYK Q11129 150 150
NCYNKGRFGTPESSHK Q09187 150 150
NCYNKGQFGAPETSYK Q03647 150 150
NCYNKGEFGTPEISYK Q99172 149 149
MELIBIASE2 Length of motif = 20 Motif number = 2
Melibiase motif II - 2
PCODE ST INT
EFTRPDSRCPCDGDEYDCKY MEL2_YEAST 213 47
EFTRPDSRCPCDGDEYDCKY MEL5_YEAST 213 47
EFTRPDSRCPCDGDEYDCKY MEL6_YEAST 213 47
EFTRPDSRCPCDGDEYDCKY MEL1_YEAST 213 47
EFDRPDSRCPCDGDQYDCSY Q11129 213 47
EFSRPDSRCPCDGDEYDCKY Q09187 213 47
QFTRPDSRCPCDGDQFDCAY Q03647 213 47
QFDRPDSRCPCSGDEYDCSY Q99172 212 47
MELIBIASE3 Length of motif = 17 Motif number = 3
Melibiase motif III - 2
PCODE ST INT
RVWRYYVSDTDEYGQGE MEL2_YEAST 326 93
RVWRYYVSDTDEYGQGE MEL5_YEAST 326 93
RVWRYYVSDTDEYGQGE MEL6_YEAST 326 93
RVWRYYVSDTDEYGQGE MEL1_YEAST 326 93
RVWRHYVSQTDKYGKGE Q11129 326 93
RVWRYYVPQTDKYGQGE Q09187 326 93
RVWRHQVPQTDKYGQGE Q03647 326 93
RIWKYHVSDKDQYGEGE Q99172 325 93
MELIBIASE4 Length of motif = 17 Motif number = 4
Melibiase motif IV - 2
PCODE ST INT
DNGDQVVALLNGGSVPR MEL2_YEAST 351 8
DNGDQVVALLNGGSVAR MEL5_YEAST 351 8
DNGDQVVALLNGGSVAR MEL6_YEAST 351 8
DNGDQVVALLNGGSVSR MEL1_YEAST 351 8
DNGDQVIALLNGSNKKR Q11129 351 8
ENGDQVIALLNGGMKAR Q09187 351 8
DNGDQVIALLNGGIKPR Q03647 351 8
DNGDHVVALLNGGNNER Q99172 350 8
MELIBIASE5 Length of motif = 24 Motif number = 5
Melibiase motif V - 2
PCODE ST INT
EEIFFDSNLGSKELTSTWDIYDLW MEL2_YEAST 374 6
EEIFFDSNLGSKELTSTWDIYDLW MEL5_YEAST 374 6
EEIFFDSNLGSKELTSTWDIYDLW MEL6_YEAST 374 6
EEIFFDSNLGSKKLTSTWDIYDLW MEL1_YEAST 374 6
EDIFFDSYLGSEELSSSWDIYDLW Q11129 374 6
EDIFFDSYQGSEELSTSWDIYDLW Q09187 374 6
EEIFFDSYLGFEQLSSNWDIYDLW Q03647 374 6
NDIFIDYLADSDELSNTWGLYDLW Q99172 373 6
MELIBIASE6 Length of motif = 23 Motif number = 6
Melibiase motif VI - 2
PCODE ST INT
RVDNSTASAILGQNKTATGILYN MEL2_YEAST 400 2
RVDNSTASAILEQNKAATGILYN MEL5_YEAST 400 2
RVDNSTASAILEQNKAATGILYN MEL6_YEAST 400 2
RVDNSTASAILGRNKTATGILYN MEL1_YEAST 400 2
RIDNTIASNILKNNKVTNSSLYN Q11129 400 2
RIDNATASAILENNKVTNNTLYN Q09187 400 2
RVDNATSANILNNNSVGNATIYN Q03647 400 2
RMSNATAASILSGNMTSAGLNYN Q99172 399 2
MELIBIASE7 Length of motif = 17 Motif number = 7
Melibiase motif VII - 2
PCODE ST INT
YKDGLSKNDTRLFGQKI MEL2_YEAST 428 5
YKDGLSKNDTRLFGQKI MEL5_YEAST 428 5
YKDGLSKNDTRLFGQKI MEL6_YEAST 428 5
YKDGLSKNDTRLFGQKI MEL1_YEAST 428 5
YKEGLSKNDTRLFGVQI Q11129 428 5
YKEGLLNGDSRLFGTKV Q09187 428 5
YKDGMAKNDTRLFGTKI Q03647 428 5
YTAGIARNDSRLFGDRV Q99172 427 5
MELIBIASE8 Length of motif = 21 Motif number = 8
Melibiase motif VIII - 2
PCODE ST INT
PNAILNTTVPAHGIAFYRLRP MEL2_YEAST 449 4
PNAILNTTVPAHGIAFYRLRP MEL5_YEAST 449 4
PNAILNTTVPAHGIAFYRLRP MEL6_YEAST 449 4
PNAILNTTVPAHGIAFYRLRP MEL1_YEAST 449 4
PGGLLNTTVPAHGVALYRLRR Q11129 449 4
PDGIINTTVPAHGIALYRLRS Q09187 449 4
PDGLLNTTVPAHGIAFYRLRR Q03647 449 4
KGESLTATVPGHGVALFRLRP Q99172 448 4
User query: Display/Full Code "MELIBIASE"