WORKLIST ENTRIES (1):
LIPOSIGPTASE View alignment Lipoprotein signal peptidase family (A8) signature
Type of fingerprint: COMPOUND with 3 elements
Links:
PRINTS; PR00792 PEPSIN; PR00731 CAULIMOPTASE; PR00977 SCYTLDPTASE
PRINTS; PR00863 NODAVIRPTASE; PR00920 SPUMVIRPTASE
INTERPRO; IPR001872
PROSITE; PS00855 SPASE_II
Creation date 10-JUN-1997; UPDATE 27-JUN-1999
1. RAWLINGS, N.D. AND BARRETT, A.J.
Families of aspartic peptidases, and those of unknown catalytic mechanism.
METHODS ENZYMOL. 248 105-120 (1995).
2. TOKUNAGA, M., LORANGER, J.M. AND WU, H.C.
Prolipoprotein modification and processing enzymes in Escherichia coli.
J.BIOL.CHEM. 259 3825-3830 (1984).
Bacterial cell walls contain large amounts of murein lipoprotein, a small
protein that is both N-terminally bound to lipid and attached to membrane
peptidoglycan (murein) through the epsilon-amino group of its C-terminal
lysine residue [1]. Secretion of this lipoprotein is facilitated by the
action of lipoprotein signal peptidase (also known as leader peptidase II),
located in the inner membrane [1,2]. The enzyme is inhibited by globomycin
and also by pepstatin, suggesting that it is an aspartic peptidase [1].
The catalytic residues have not been identified, but three conserved
aspartates can be identified from sequence alignments.
LIPOSIGPTASE is a 3-element fingerprint that provides a signature for the
lipoprotein signal peptidase family (A8) of aspartate endopeptidases. The
fingerprint was derived from an initial alignment of 7 sequences: the
motifs were drawn from conserved regions spanning virtually the full
alignment length - motif 2 includes the region encoded by PROSITE pattern
SPASE_II (PS00855), which contains one of the conserved aspartate residues;
and motif 3 contains a second conserved Asp. Two iterations on OWL29.3 were
required to reach convergence, at which point a true set comprising 11
sequences was identified. A single partial match was also found, LLU63724,
a fragment that lacks the region of sequence bearing motif 3.
An update on SPTR37_9f identified a true set of 18 sequences, and 1
partial match.
SUMMARY INFORMATION
18 codes involving 3 elements
1 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
3| 18 18 18
2| 0 1 1
--+----------------
| 1 2 3
True positives..
LSPA_ENTAE LSPA_ECOLI LSPA_PSEFL O67692
LSPA_HAEIN O52213 LSPA_STAAU LSPA_BACSU
LSPA_MYCTU LSPA_SYNY3 LSPA_STACA O84413
O83943 LSPA_MYCGE LSPA_MYCPN LSPA_HELPY
O51425 ZNUB_ECOLI
Subfamily: Codes involving 2 elements
Subfamily True positives..
O87781
PROTEIN TITLES
LSPA_ENTAE LIPOPROTEIN SIGNAL PEPTIDASE (EC 3.4.23.36) (PROLIPOPROTEIN
LSPA_ECOLI LIPOPROTEIN SIGNAL PEPTIDASE (EC 3.4.23.36) (PROLIPOPROTEIN
LSPA_PSEFL LIPOPROTEIN SIGNAL PEPTIDASE (EC 3.4.23.36) (PROLIPOPROTEIN
O67692 LIPOPROTEIN SIGNAL PEPTIDASE (EC 3.4.23.36) (PROLIPOPROTEIN
LSPA_HAEIN LIPOPROTEIN SIGNAL PEPTIDASE (EC 3.4.23.36) (PROLIPOPROTEIN
O52213 LSPA - SERRATIA MARCESCENS.
LSPA_STAAU LIPOPROTEIN SIGNAL PEPTIDASE (EC 3.4.23.36) (PROLIPOPROTEIN
LSPA_BACSU LIPOPROTEIN SIGNAL PEPTIDASE (EC 3.4.23.36) (PROLIPOPROTEIN
LSPA_MYCTU PROBABLE LIPOPROTEIN SIGNAL PEPTIDASE (EC 3.4.23.36) (PROLIP
LSPA_SYNY3 LIPOPROTEIN SIGNAL PEPTIDASE (EC 3.4.23.36) (PROLIPOPROTEIN
LSPA_STACA LIPOPROTEIN SIGNAL PEPTIDASE (EC 3.4.23.36) (PROLIPOPROTEIN
O84413 LIPOPROTEIN SIGNAL PEPTIDASE - CHLAMYDIA TRACHOMATIS.
O83943 SIGNAL PEPTIDASE II (LSP) - TREPONEMA PALLIDUM.
LSPA_MYCGE PUTATIVE LIPOPROTEIN SIGNAL PEPTIDASE (EC 3.4.23.36) (PROLIP
LSPA_MYCPN PUTATIVE LIPOPROTEIN SIGNAL PEPTIDASE (EC 3.4.23.36) (PROLIP
LSPA_HELPY LIPOPROTEIN SIGNAL PEPTIDASE (EC 3.4.23.36) (PROLIPOPROTEIN
O51425 SIGNAL PEPTIDASE II (LSP) - BORRELIA BURGDORFERI (LYME DISEA
ZNUB_ECOLI HIGH-AFFINITY ZINC UPTAKE SYSTEM MEMBRANE PROTEIN ZNUB - ESC
O87781 SPASE II - MYXOCOCCUS XANTHUS.
SCAN HISTORY
OWL29_3 2 110 NSINGLE
SPTR37_9f 3 100 NSINGLE
INITIAL MOTIF SETS
LIPOSIGPTASE1 Length of motif = 9 Motif number = 1
Lipoprotein signal peptidase motif I - 1
PCODE ST INT
NYGAAFSFL LSPA_ECOLI 53 53
NTGAAFSFL LSPA_PSEFL 55 55
NKGVGFSLL B64223 72 72
NKGVGFSLL S73868 76 76
NSGAAFSMA LSPA_MYCTU 78 78
NNGAAWGIL LSPA_STAAU 52 52
NTGAAWGIL BSU488702 45 45
LIPOSIGPTASE2 Length of motif = 16 Motif number = 2
Lipoprotein signal peptidase motif II - 1
PCODE ST INT
YALIIGGALGNLFDRL LSPA_ECOLI 101 39
LALVLGGALGNLYDRI LSPA_PSEFL 103 39
ITTLAFGSLGNFFDRL B64223 114 33
ITTLAFGSLGNFFDRL S73868 118 33
LGMILGGAMGNLVDRF LSPA_MYCTU 120 33
ISLLFAGALGNFIDRI LSPA_STAAU 96 35
LGLMLGGAIGNFIDRA BSU488702 89 35
LIPOSIGPTASE3 Length of motif = 17 Motif number = 3
Lipoprotein signal peptidase motif III - 1
PCODE ST INT
FNLADTAICVGAALIVL LSPA_ECOLI 137 20
FNFADSAITVGAIMLAL LSPA_PSEFL 140 21
FNFADCCITFGFIGLFF B64223 149 19
FNLADCCITFSFIGLFL S73868 153 19
FNVADPSVVGGAILLVI LSPA_MYCTU 158 22
FNIADSSLTIGVILIII LSPA_STAAU 132 20
FNIADSSLCVGVMLLFI BSU488702 125 20
FINAL MOTIF SETS
LIPOSIGPTASE1 Length of motif = 9 Motif number = 1
Lipoprotein signal peptidase motif I - 3
PCODE ST INT
NYGAAFSFL LSPA_ENTAE 53 53
NYGAAFSFL LSPA_ECOLI 53 53
NTGAAFSFL LSPA_PSEFL 55 55
NKGVAFGLL O67692 51 51
NYGAAFSFL LSPA_HAEIN 50 50
NTGAAFSLF O52213 54 54
NNGAAWGIL LSPA_STAAU 52 52
NTGAAWGIL LSPA_BACSU 45 45
NSGAAFSMA LSPA_MYCTU 78 78
NTGAAFSAF LSPA_SYNY3 56 56
NNGAAWGIL LSPA_STACA 52 52
NEGAAFGLF O84413 58 58
NVGAAFSIG O83943 67 67
NKGVGFSLL LSPA_MYCGE 72 72
NKGVGFSLL LSPA_MYCPN 76 76
NKGVAFSLL LSPA_HELPY 48 48
NTGILFSMG O51425 54 54
LLGVAFGLL ZNUB_ECOLI 43 43
LIPOSIGPTASE2 Length of motif = 16 Motif number = 2
Lipoprotein signal peptidase motif II - 3
PCODE ST INT
YALIIGGALGNLFDRL LSPA_ENTAE 101 39
YALIIGGALGNLFDRL LSPA_ECOLI 101 39
LALVLGGALGNLYDRI LSPA_PSEFL 103 39
MGLIGGGALGNLYDRL O67692 98 38
YALIIGGALANMVDRA LSPA_HAEIN 98 39
YSLILGGAMGNLIDRV O52213 100 37
ISLLFAGALGNFIDRI LSPA_STAAU 96 35
LGLMLGGAIGNFIDRA LSPA_BACSU 89 35
LGMILGGAMGNLVDRF LSPA_MYCTU 120 33
YGCILAGAVGNGIDRF LSPA_SYNY3 99 34
ISLLFAGALGNFIDRM LSPA_STACA 96 35
LTLILAGALGNVGDIL O84413 103 36
VSGIIGGGIGNLIDRF O83943 116 40
ITTLAFGSLGNFFDRL LSPA_MYCGE 114 33
ITTLAFGSLGNFFDRL LSPA_MYCPN 118 33
FGMVFGAGVSNVLDRF LSPA_HELPY 92 35
LLLIFSGGVGNVIDRL O51425 101 38
VTLLLAGGLVWLEKRP ZNUB_ECOLI 63 11
LIPOSIGPTASE3 Length of motif = 17 Motif number = 3
Lipoprotein signal peptidase motif III - 3
PCODE ST INT
FNLADSAICIGAALIVL LSPA_ENTAE 137 20
FNLADTAICVGAALIVL LSPA_ECOLI 137 20
FNFADSAITVGAIMLAL LSPA_PSEFL 140 21
FNIADASISIGIALLIL O67692 134 20
FNIADIAICIGAGLLVL LSPA_HAEIN 134 20
FNLADIAIVLGALLFVS O52213 136 20
FNIADSSLTIGVILIII LSPA_STAAU 132 20
FNIADSSLCVGVMLLFI LSPA_BACSU 125 20
FNVADPSVVGGAILLVI LSPA_MYCTU 158 22
FNLADVSINIGIAALLW LSPA_SYNY3 133 18
FNGADSSLTIGVILVLI LSPA_STACA 132 20
FNLADAFISIGTLLLIG O84413 139 20
FNIADAVIMTCGLLLII O83943 157 25
FNFADCCITFGFIGLFF LSPA_MYCGE 149 19
FNLADCCITFSFIGLFL LSPA_MYCPN 153 19
FNFADVMIDVGVGVLLL LSPA_HELPY 127 19
FNFADSYVVIGMILFLV O51425 142 25
DTPAGPSVVLCAALLFI ZNUB_ECOLI 236 157
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