WORKLIST ENTRIES (1):
KCNQCHANNEL View alignment KCNQ voltage-gated potassium channel family signature
Type of fingerprint: COMPOUND with 3 elements
Links:
PRINTS; PR00169 KCHANNEL; PR01460 KCNQ1CHANNEL; PR01461 KCNQ2CHANNEL
PRINTS; PR01462 KCNQ3CHANNEL
Creation date 29-NOV-2000
1. MILLER, C.
An overview of the potassium channel family.
GENOME BIOL. 1(4) 1-5 (2000).
2. ASHCROFT, F.M.
Voltage-gated K+ channels.
IN ION CHANNELS AND DISEASE, ACADEMIC PRESS, 2000, PP.111-116.
3. SANGUINETTI, M.C.
Maximal function of minimal K+ channel subunits.
TRENDS PHARMACOL.SCI. 21 199-201 (2000).
4. WANG, Q., CURRAN, M.E., SPLAWSKI, I., BURN, T.C., MILLHOLLAND, J.M.,
VANRAAY, T.J., SHEN, J., TIMOTHY, K.W., VINCENT, G.M., DE JAGER, T.,
SCHWARTZ, P.J., TOUBIN, J.A., MOSS, A.J., ATKINSON, D.L., LANDES, G.M.,
CONNORS, T.D. AND KEATING, M.T.
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause
cardiac arrhythmias.
NAT.GENET. 12(1) 17-23 (1996).
5. BIERVERT, C., SCHROEDER, B.C., KUBISCH, C., BERKOVIC, S.F., PROPPING, P.,
JENTSCH, T.J. AND STEINLEIN, O.K.
A potassium channel mutation in neonatal human epilepsy.
SCIENCE 279 403-406 (1998).
Potassium ion (K+) channels are a structurally diverse group of proteins
that facilitate the flow of K+ ions across cell membranes. They are
ubiquitous, being present in virtually all cell types. Activation of K+
channels tends to hyperpolarise cells, reducing the membrane's electrical
resistance, dampening nervous activity. In eukaryotic cells, K+ channels
are involved in neural signalling and generation of the cardiac rhythm, and
act as effectors in signal transduction pathways involving G protein-
coupled receptors (GPCRs). In prokaryotic cells, they play a role in the
maintenance of ionic homeostasis [1].
Structurally, KCNQ channels belong to the subfamily of K+ channels whose
subunits contain 6 transmembrane (TM) domains: these are the voltage-gated
K+ channels, the KCNQ channels, the EAG-like K+ channels and 3 kinds of
Ca2+-activated K+ channel (BK, IK and SK) [2]. All K+ channels share a
characteristic sequence feature: a TMxTVGYG motif that resides between
the 2 C-terminal membrane-spanning helices, and forms the K+-selective
pore domain [1].
KCNQ channels differ from other voltage-gated 6 TM helix channels, chiefly
in that they possess no tetramerisation domain. Consequently, they rely on
interaction with accessory subunits, or form heterotetramers with other
members of the family [3]. Currently, 5 members of the KCNQ family are
known. These have been found to be widely distributed within the body,
having been shown to be expressed in the heart, brain, pancreas, lung,
placenta and ear. They were initially cloned as a result of a search for
proteins involved in cardiac arhythmia. Subsequently, mutations in other
KCNQ family members have been shown to be responsible for some forms of
hereditary deafness [4] and benign familial neonatal epilepsy [5].
KCNQCHANNEL is a 3-element fingerprint that provides a signature for the
KCNQ voltage-gated potassium channel family. The fingerprint was derived
from an initial alignment of 25 sequences: the motifs were drawn from
conserved regions spanning the N-terminal third of the alignment, focusing
on those sections that characterise the KCNQ channels but distinguish them
from other members of the K+ channel superfamily - motifs 1 and 2 span the
putative extracellular loop region between the putative TM domains 1 and 2;
and motif 3 spans the putative intracellular loop between TM domains 3 and
4. Two iterations on SPTR39_14f were required to reach convergence, at
which point a true set comprising 31 sequences was identified.
SUMMARY INFORMATION
31 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
3| 31 31 31
2| 0 0 0
--+----------------
| 1 2 3
True positives..
O43526 Q9Z351 Q9Z350 Q9Z349
Q9Z348 Q9Z347 Q9Z346 Q9Z345
Q9Z344 Q9Z343 Q9Z342 Q9QWN9
Q99454 O95845 O88943 O75580
O43796 CIQ4_HUMAN Q9Z240 O88944
CIQ3_HUMAN CIQ1_HUMAN O94787 CIQ1_MOUSE
Q9Z0N7 O73925 Q9UMN8 Q9UMN9
Q18147 Q9V5H7 Q9XWG9
PROTEIN TITLES
O43526 POTASSIUM CHANNEL - Homo sapiens (Human).
Q9Z351 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB00
Q9Z350 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB00
Q9Z349 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB00
Q9Z348 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB00
Q9Z347 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB00
Q9Z346 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB00
Q9Z345 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB00
Q9Z344 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB00
Q9Z343 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB00
Q9Z342 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB00
Q9QWN9 ALTERNATIVE SPLICING:SEE ACCESSION BETWEEN AB000494 AND AB00
Q99454 NEUROBLASTOMA-SPECIFIC POTASSIUM CHANNEL PROTEIN - Homo sapi
O95845 POTASSIUM CHANNEL - Homo sapiens (Human).
O88943 POTASSIUM CHANNEL - Rattus norvegicus (Rat).
O75580 NEURONAL DELAYED-RECTIFIER VOLTAGE-GATED POTASSIUM CHANNEL S
O43796 VOLTAGE GATED POTASSIUM CHANNEL - Homo sapiens (Human).
CIQ4_HUMAN VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KQT-LIKE 4 - Homo sa
Q9Z240 POTASSIUM CHANNEL - Rattus norvegicus (Rat).
O88944 POTASSIUM CHANNEL - Rattus norvegicus (Rat).
CIQ3_HUMAN VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KQT-LIKE 3 - Homo sa
CIQ1_HUMAN VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KQT-LIKE 1 (KV1.9) -
O94787 KVLQT1 ISOFORM1 PROTEIN - Homo sapiens (Human).
CIQ1_MOUSE VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KQT-LIKE 1 (KV1.9) -
Q9Z0N7 KVLQT-1 POTASSIUM CHANNEL - Rattus norvegicus (Rat).
O73925 KVLQT POTASSIUM CHANNEL - Squalus acanthias (Spiny dogfish).
Q9UMN8 KVLQT1 PROTEIN - Homo sapiens (Human).
Q9UMN9 KVLQT1 PROTEIN - Homo sapiens (Human).
Q18147 HYPOTHETICAL 83.8 KDA PROTEIN C25B8.1 IN CHROMOSOME X - Caen
Q9V5H7 CG12215 PROTEIN - Drosophila melanogaster (Fruit fly).
Q9XWG9 Y54G9A.3 PROTEIN - Caenorhabditis elegans.
SCAN HISTORY
SPTR39_14f 2 300 NSINGLE
INITIAL MOTIF SETS
KCNQCHANNEL1 Length of motif = 20 Motif number = 1
KCNQ voltage-gated potassium channel family motif I - 1
PCODE ST INT
IFGAEFALRIWAAGCCCRYK CIQ3_HUMAN 166 166
IFGAEFALRIWAAGCCCRYK O88944 167 167
IFGAEFALRIWAAGCCCRYK Q9Z240 129 129
VFGVEYFVRIWAAGCCCRYR O75580 136 136
VFGVEYFVRIWAAGCCCRYR O88943 136 136
VFGVEYFVRIWAAGCCCRYR O43526 136 136
VFGVEYFVRIWAAGCCCRYR O95845 136 136
VFGVEYFVRIWAAGCCCRYR O43796 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z351 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z349 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z350 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z348 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z347 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z346 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z345 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z344 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z343 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z342 136 136
VFGVEYFVRIWAAGCCCRYR Q99454 136 136
VFGVEYFVRIWAAGCCCRYR O95845 136 136
VFGLEYIVRVWSAGCCCRYR CIQ4_HUMAN 142 142
FFGTEYIVRLWSAGCRSKYV O73925 159 159
KCNQCHANNEL2 Length of motif = 20 Motif number = 2
KCNQ voltage-gated potassium channel family motif II - 1
PCODE ST INT
GWRGRLKFARKPLCMLDIFV CIQ3_HUMAN 186 0
GWRGRLKFARKPLCMLDIFV O88944 187 0
GWRGRLKFARKPLCMLDIFV Q9Z240 149 0
GWRGRLKFARKPFCVIDIMV O75580 156 0
GWRGRLKFARKPFCVIDIMV O88943 156 0
GWRGRLKFARKPFCVIDIMV O43526 156 0
GWRGRLKFARKPFCVIDIMV O95845 156 0
GWRGRLKFARKPFCVIDIMV O43796 156 0
GWRGRLKFARKPFCVIDIMV Q9Z351 156 0
GWRGRLKFARKPFCVIDIMV Q9Z349 156 0
GWRGRLKFARKPFCVIDIMV Q9Z350 156 0
GWRGRLKFARKPFCVIDIMV Q9Z348 156 0
GWRGRLKFARKPFCVIDIMV Q9Z347 156 0
GWRGRLKFARKPFCVIDIMV Q9Z346 156 0
GWRGRLKFARKPFCVIDIMV Q9Z345 156 0
GWRGRLKFARKPFCVIDIMV Q9Z344 156 0
GWRGRLKFARKPFCVIDIMV Q9Z343 156 0
GWRGRLKFARKPFCVIDIMV Q9Z342 156 0
GWRGRLKFARKPFCVIDIMV Q99454 156 0
GWRGRLKFARKPFCVIDIMV O95845 156 0
GWQGRFRFARKPFCVIDFIV CIQ4_HUMAN 162 0
GFWGRLRFARKPISIIDLIV O73925 179 0
KCNQCHANNEL3 Length of motif = 20 Motif number = 3
KCNQ voltage-gated potassium channel family motif III - 1
PCODE ST INT
WKLLGSAICAHSKELITAWY CIQ3_HUMAN 247 41
WKLLGSAICAHSKELITAWY O88944 248 41
WKLLGSAICAHSKELITAWY Q9Z240 210 41
WKLLGSVVYAHSKELVTAWY O75580 218 42
WKLLGSVVYAHSKELVTAWY O88943 218 42
WKLLGSVVYAHSKELVTAWY O43526 218 42
WKLLGSVVYAHSKELVTAWY O95845 218 42
WKLLGSVVYAHSKELVTAWY O43796 218 42
WKLLGSVVYAHSKELVTAWY Q9Z351 218 42
WKLLGSVVYAHSKELVTAWY Q9Z349 218 42
WKLLGSVVYAHSKELVTAWY Q9Z350 218 42
WKLLGSVVYAHSKELVTAWY Q9Z348 218 42
WKLLGSVVYAHSKELVTAWY Q9Z347 218 42
WKLLGSVVYAHSKELVTAWY Q9Z346 218 42
WKLLGSVVYAHSKELVTAWY Q9Z345 218 42
WKLLGSVVYAHSKELVTAWY Q9Z344 218 42
WKLLGSVVYAHSKELVTAWY Q9Z343 218 42
WKLLGSVVYAHSKELVTAWY Q9Z342 218 42
WKLLGSVVYAHSKELVTAWY Q99454 218 42
WKLLGSVVYAHSKELVTAWY O95845 218 42
WKLLGSVVYAHSKELITAWY CIQ4_HUMAN 224 42
WRLLGSVVFIHRQELITTLY O73925 241 42
FINAL MOTIF SETS
KCNQCHANNEL1 Length of motif = 20 Motif number = 1
KCNQ voltage-gated potassium channel family motif I - 2
PCODE ST INT
VFGVEYFVRIWAAGCCCRYR O43526 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z351 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z350 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z349 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z348 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z347 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z346 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z345 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z344 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z343 136 136
VFGVEYFVRIWAAGCCCRYR Q9Z342 136 136
VFGVEYFVRIWAAGCCCRYR Q9QWN9 136 136
VFGVEYFVRIWAAGCCCRYR Q99454 136 136
VFGVEYFVRIWAAGCCCRYR O95845 136 136
VFGVEYFVRIWAAGCCCRYR O88943 136 136
VFGVEYFVRIWAAGCCCRYR O75580 136 136
VFGVEYFVRIWAAGCCCRYR O43796 136 136
VFGLEYIVRVWSAGCCCRYR CIQ4_HUMAN 142 142
IFGAEFALRIWAAGCCCRYK CIQ3_HUMAN 166 166
IFGAEFALRIWAAGCCCRYK O88944 167 167
IFGAEFALRIWAAGCCCRYK Q9Z240 129 129
FFGTEYVVRLWSAGCRSKYV CIQ1_HUMAN 166 166
FFGTEYVVRLWSAGCRSKYV O94787 166 166
FFGTEYVVRLWSAGCRSKYV CIQ1_MOUSE 101 101
FFGTEYVVRLWSAGCRSKYV Q9Z0N7 166 166
FFGTEYIVRLWSAGCRSKYV O73925 159 159
FFXTEYVVRLWSAGCRSKYV Q9UMN8 39 39
FFXTEYVVRLWSAGCRSKYV Q9UMN9 166 166
WLATEYICRVWSAGCRSRYR Q18147 168 168
WFTMEFGARLWSSGCRSRYQ Q9V5H7 83 83
FFSVEFIVRLWSAGCRSKYI Q9XWG9 63 63
KCNQCHANNEL2 Length of motif = 20 Motif number = 2
KCNQ voltage-gated potassium channel family motif II - 2
PCODE ST INT
GWRGRLKFARKPFCVIDIMV O43526 156 0
GWRGRLKFARKPFCVIDIMV Q9Z351 156 0
GWRGRLKFARKPFCVIDIMV Q9Z350 156 0
GWRGRLKFARKPFCVIDIMV Q9Z349 156 0
GWRGRLKFARKPFCVIDIMV Q9Z348 156 0
GWRGRLKFARKPFCVIDIMV Q9Z347 156 0
GWRGRLKFARKPFCVIDIMV Q9Z346 156 0
GWRGRLKFARKPFCVIDIMV Q9Z345 156 0
GWRGRLKFARKPFCVIDIMV Q9Z344 156 0
GWRGRLKFARKPFCVIDIMV Q9Z343 156 0
GWRGRLKFARKPFCVIDIMV Q9Z342 156 0
GWRGRLKFARKPFCVIDIMV Q9QWN9 156 0
GWRGRLKFARKPFCVIDIMV Q99454 156 0
GWRGRLKFARKPFCVIDIMV O95845 156 0
GWRGRLKFARKPFCVIDIMV O88943 156 0
GWRGRLKFARKPFCVIDIMV O75580 156 0
GWRGRLKFARKPFCVIDIMV O43796 156 0
GWQGRFRFARKPFCVIDFIV CIQ4_HUMAN 162 0
GWRGRLKFARKPLCMLDIFV CIQ3_HUMAN 186 0
GWRGRLKFARKPLCMLDIFV O88944 187 0
GWRGRLKFARKPLCMLDIFV Q9Z240 149 0
GLWGRLRFARKPISIIDLIV CIQ1_HUMAN 186 0
GLWGRLRFARKPISIIDLIV O94787 186 0
GIWGRLRFARKPISIIDLIV CIQ1_MOUSE 121 0
GIWGRLRFARKPISIIDLIV Q9Z0N7 186 0
GFWGRLRFARKPISIIDLIV O73925 179 0
GLWGRLRFARKPISIIDLIV Q9UMN8 59 0
GLWGRLRFARKPISIIDLIV Q9UMN9 186 0
GISGRIRFATSAYCVIDIIV Q18147 188 0
GCLGRLKFVKRPFCIIDIVT Q9V5H7 103 0
GVYGRLKFVRKPITLIGRFG Q9XWG9 83 0
KCNQCHANNEL3 Length of motif = 20 Motif number = 3
KCNQ voltage-gated potassium channel family motif III - 2
PCODE ST INT
WKLLGSVVYAHSKELVTAWY O43526 218 42
WKLLGSVVYAHSKELVTAWY Q9Z351 218 42
WKLLGSVVYAHSKELVTAWY Q9Z350 218 42
WKLLGSVVYAHSKELVTAWY Q9Z349 218 42
WKLLGSVVYAHSKELVTAWY Q9Z348 218 42
WKLLGSVVYAHSKELVTAWY Q9Z347 218 42
WKLLGSVVYAHSKELVTAWY Q9Z346 218 42
WKLLGSVVYAHSKELVTAWY Q9Z345 218 42
WKLLGSVVYAHSKELVTAWY Q9Z344 218 42
WKLLGSVVYAHSKELVTAWY Q9Z343 218 42
WKLLGSVVYAHSKELVTAWY Q9Z342 218 42
WKLLGSVVYAHSKELVTAWY Q9QWN9 218 42
WKLLGSVVYAHSKELVTAWY Q99454 218 42
WKLLGSVVYAHSKELVTAWY O95845 218 42
WKLLGSVVYAHSKELVTAWY O88943 218 42
WKLLGSVVYAHSKELVTAWY O75580 218 42
WKLLGSVVYAHSKELVTAWY O43796 218 42
WKLLGSVVYAHSKELITAWY CIQ4_HUMAN 224 42
WKLLGSAICAHSKELITAWY CIQ3_HUMAN 247 41
WKLLGSAICAHSKELITAWY O88944 248 41
WKLLGSAICAHSKELITAWY Q9Z240 210 41
WRLLGSVVFIHRQELITTLY CIQ1_HUMAN 248 42
WRLLGSVVFIHRQELITTLY O94787 248 42
WRLLGSVVFIHRQELITTLY CIQ1_MOUSE 183 42
WRLLGSVVFIHRQELITTLY Q9Z0N7 248 42
WRLLGSVVFIHRQELITTLY O73925 241 42
WRLLGSVVFIHRQELITTLY Q9UMN8 121 42
WRLLGSVVFIHRQELITTLY Q9UMN9 248 42
WKLLGSVVWAHRQELLTTVY Q18147 250 42
WKLLGSVVYAHRQQELITTM Q9V5H7 165 42
RRLLGSVVFIHRQELITTLY Q9XWG9 226 123
User query: Display/Full Code "KCNQCHANNEL"