WORKLIST ENTRIES (1):
KCNQ1CHANNEL View alignment KCNQ1 voltage-gated potassium channel signature
Type of fingerprint: COMPOUND with 9 elements
Links:
PRINTS; PR00169 KCHANNEL; PR01459 KCNQCHANNEL; PR01461 KCNQ2CHANNEL
PRINTS; PR01462 KCNQ3CHANNEL
Creation date 14-NOV-2000
1. MILLER, C.
An overview of the potassium channel family.
GENOME BIOL. 1(4) 1-5 (2000).
2. ASHCROFT, F.M.
Voltage-gated K+ channels.
IN ION CHANNELS AND DISEASE, ACADEMIC PRESS, 2000, PP.111-116.
3. SANGUINETTI, M. C.
Maximal function of minimal K+ channel subunits.
TRENDS PHARMACOL.SCI. 21 199-201 (2000).
4. WANG Q., CURRAN, M.E., SPLAWSKI, I., BURN, T.C., MILLHOLLAND, J.M.,
VANRAAY, T.J., SHEN, J., TIMOTHY, K.W., VINCENT, G.M., DE JAGER, T.,
SCHWARTZ, P.J., TOUBIN, J.A., MOSS, A.J., ATKINSON, D.L., LANDES, G.M.,
CONNORS, T.D. AND KEATING, M.T.
Positional cloning of a novel potassium channel gene: KVLQT1 mutations
cause cardiac arrhythmias.
NAT.GENET. 12(1) 17-23 (1996).
5. BIERVERT, C., SCHROEDER, B.C., KUBISCH, C., BERKOVIC, S.F., PROPPING, P.,
JENTSCH, T.J. AND STEINLEIN, O.K.
A potassium channel mutation in neonatal human epilepsy.
SCIENCE 279 403-406 (1998).
6. SANGUINETTI, M.C., CURRAN, M.E., ZOU, A., SHEN, J., SPECTOR, P.S.,
ATKINSON, D.L. AND KEATING, M.T.
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks)
potassium channel.
NATURE 384 80-83 (1996).
7. NEYROUD, N., TESSON, F., DENJOY, I., LEIBOVICI, M., DONGER, C.,
BARHANIN, J., FAURE, S., GARY, F., COUMEL, P., PETIT, C., SCHWARTZ, K.
AND GUICHENEY, P.
A novel mutation in the potassium channel gene KVLQT1 causes the Jervell
and Lange-Nielsen cardioauditory syndrome.
NAT.GENET. 15(2) 186-189 (1997).
Potassium ion (K+) channels are a structurally diverse group of proteins
that facilitate the flow of K+ ions across cell membranes. They are
ubiquitous, being present in virtually all cell types. Activation of K+
channels tends to hyperpolarise cells, reducing the membrane's electrical
resistance, dampening nervous activity. In eukaryotic cells, K+ channels
are involved in neural signalling and generation of the cardiac rhythm, and
act as effectors in signal transduction pathways involving G protein-
coupled receptors (GPCRs). In prokaryotic cells, they play a role in the
maintenance of ionic homeostasis [1].
Structurally, KCNQ channels belong to the subfamily of K+ channels whose
subunits contain 6 transmembrane (TM) domains: these are the voltage-gated
K+ channels, the KCNQ channels, the EAG-like K+ channels and 3 kinds of
Ca2+-activated K+ channel (BK, IK and SK) [2]. All K+ channels share a
characteristic sequence feature: a TMxTVGYG motif that resides between
the 2 C-terminal membrane-spanning helices, and forms the K+-selective
pore domain [1].
KCNQ channels differ from other voltage-gated 6 TM helix channels, chiefly
in that they possess no tetramerisation domain. Consequently, they rely on
interaction with accessory subunits, or form heterotetramers with other
members of the family [3]. Currently, 5 members of the KCNQ family are
known. These have been found to be widely distributed within the body,
having been shown to be expressed in the heart, brain, pancreas, lung,
placenta and ear. They were initially cloned as a result of a search for
proteins involved in cardiac arhythmia. Subsequently, mutations in other
KCNQ family members have been shown to be responsible for some forms of
hereditary deafness [4] and benign familial neonatal epilepsy [5].
KCNQ1 was the first member of the KCNQ channel family to be isolated, and
has been found to be the most common cause of the disease 'long QT syndrome'
a cardiac arhythmia resulting in a prolonged QT interval. In exceptional
cases, this can lead to sudden death, triggered by extreme stress [6].
KCNQ1 is expressed in the stria vascularis of the inner ear, and may be
the cause of hereditary deafness [7].
KCNQ1CHANNEL is a 9-element fingerprint that provides a signature for the
KCNQ1 voltage-gated potassium channel subtype. The fingerprint was derived
from an initial alignment of 5 sequences: the motifs were drawn from the
C-terminal portion of the alignment, focusing on those sections that
characterise the KCNQ1 channel but distinguish it from other members of
the K+ channel superfamily - motifs 1-9 span the C-terminal intracellular
region. Two iterations on SPTR39_14f were required to reach convergence,
at which point a true set comprising 7 sequences was identified.
SUMMARY INFORMATION
7 codes involving 9 elements
0 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
9| 7 7 7 7 7 7 7 7 7
8| 0 0 0 0 0 0 0 0 0
7| 0 0 0 0 0 0 0 0 0
6| 0 0 0 0 0 0 0 0 0
5| 0 0 0 0 0 0 0 0 0
4| 0 0 0 0 0 0 0 0 0
3| 0 0 0 0 0 0 0 0 0
2| 0 0 0 0 0 0 0 0 0
--+----------------------------------------------
| 1 2 3 4 5 6 7 8 9
True positives..
CIQ1_HUMAN Q9UMN9 Q9UMN8 O94787
Q9Z0N7 CIQ1_MOUSE O73925
PROTEIN TITLES
CIQ1_HUMAN VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KQT-LIKE 1 (KV1.9) -
Q9UMN9 KVLQT1 PROTEIN - Homo sapiens (Human).
Q9UMN8 KVLQT1 PROTEIN - Homo sapiens (Human).
O94787 KVLQT1 ISOFORM1 PROTEIN - Homo sapiens (Human).
Q9Z0N7 KVLQT-1 POTASSIUM CHANNEL - Rattus norvegicus (Rat).
CIQ1_MOUSE VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KQT-LIKE 1 (KV1.9) -
O73925 KVLQT POTASSIUM CHANNEL - Squalus acanthias (Spiny dogfish).
SCAN HISTORY
SPTR39_14f 2 50 NSINGLE
INITIAL MOTIF SETS
KCNQ1CHANNEL1 Length of motif = 15 Motif number = 1
KCNQ1 voltage-gated potassium channel motif I - 1
PCODE ST INT
KKKKFKLDKDNGVTP O94787 419 419
KKKKFKLDKDNGVTP CIQ1_HUMAN 419 419
KKKKFKLDKDNGLSP Q9Z0N7 419 419
KKKKFKLDKDNGMSP CIQ1_MOUSE 354 354
KRKKLKTDKDNGLNS O73925 410 410
KCNQ1CHANNEL2 Length of motif = 22 Motif number = 2
KCNQ1 voltage-gated potassium channel motif II - 1
PCODE ST INT
EKMLTVPHITCDPPEERRLDHF O94787 435 1
EKMLTVPHITCDPPEERRLDHF CIQ1_HUMAN 435 1
EKIFNVPHITCDPPEDRRPDHF Q9Z0N7 435 1
EKMFNVPHITYDPPEDRRPDHF CIQ1_MOUSE 370 1
EKSLNVPNITYDHVVDKDDRKF O73925 425 0
KCNQ1CHANNEL3 Length of motif = 15 Motif number = 3
KCNQ1 voltage-gated potassium channel motif III - 1
PCODE ST INT
SVDGYDSSVRKSPTL O94787 457 0
SVDGYDSSVRKSPTL CIQ1_HUMAN 457 0
SIDGYDSSVRKSPTL Q9Z0N7 457 0
SIDGYDSSVRKSPTL CIQ1_MOUSE 392 0
NIDGYDSSVKKSLGI O73925 450 3
KCNQ1CHANNEL4 Length of motif = 15 Motif number = 4
KCNQ1 voltage-gated potassium channel motif IV - 1
PCODE ST INT
LEVSMPHFMRTNSFA O94787 472 0
LEVSMPHFMRTNSFA CIQ1_HUMAN 472 0
LEVSTPHFLRTNSFA Q9Z0N7 472 0
LELSTPHFLRTNSFA CIQ1_MOUSE 407 0
LDVNSGALSRANSYA O73925 465 0
KCNQ1CHANNEL5 Length of motif = 17 Motif number = 5
KCNQ1 voltage-gated potassium channel motif V - 1
PCODE ST INT
LEGETLLTPITHISQLR O94787 491 4
LEGETLLTPITHISQLR CIQ1_HUMAN 491 4
LEGETLLTPITHVSQLR Q9Z0N7 491 4
LEGETLLTPITHVSQLR CIQ1_MOUSE 426 4
IEGEPVLAPITHVSQLR O73925 485 5
KCNQ1CHANNEL6 Length of motif = 18 Motif number = 6
KCNQ1 voltage-gated potassium channel motif VI - 1
PCODE ST INT
EHHRATIKVIRRMQYFVA O94787 508 0
EHHRATIKVIRRMQYFVA CIQ1_HUMAN 508 0
DHHRATIKVIRRMQYFVA Q9Z0N7 508 0
DHHRATIKVIRRMQYFVA CIQ1_MOUSE 443 0
ESHRVTVKVIRRMQYFVA O73925 502 0
KCNQ1CHANNEL7 Length of motif = 20 Motif number = 7
KCNQ1 voltage-gated potassium channel motif VII - 1
PCODE ST INT
VSEKSKDRGSNTIGARLNRV O94787 576 50
VSEKSKDRGSNTIGARLNRV CIQ1_HUMAN 576 50
ISEKSKDRGSNTIGARLNRV Q9Z0N7 576 50
ISEKSKDRGSNTIGARLNRV CIQ1_MOUSE 511 50
VSEKSQDRGKNTIGARLNRV O73925 570 50
KCNQ1CHANNEL8 Length of motif = 21 Motif number = 8
KCNQ1 voltage-gated potassium channel motif VIII - 1
PCODE ST INT
EDKVTQLDQRLALITDMLHQL O94787 596 0
EDKVTQLDQRLALITDMLHQL CIQ1_HUMAN 596 0
EDKVTQLDQRLVIITDMLHQL Q9Z0N7 596 0
EDKVTQLDQRLVIITDMLHQL CIQ1_MOUSE 531 0
EEKFVHMDQKLNTITDMLHHL O73925 590 0
KCNQ1CHANNEL9 Length of motif = 14 Motif number = 9
KCNQ1 voltage-gated potassium channel motif IX - 1
PCODE ST INT
PELFLPSNTLPTYE O94787 650 33
PELFLPSNTLPTYE CIQ1_HUMAN 650 33
PELFLPSNSLPTYE Q9Z0N7 643 26
PELFLPSNSLPTYE CIQ1_MOUSE 578 26
THSSLPSYEQLTVR O73925 637 26
FINAL MOTIF SETS
KCNQ1CHANNEL1 Length of motif = 15 Motif number = 1
KCNQ1 voltage-gated potassium channel motif I - 2
PCODE ST INT
KKKKFKLDKDNGVTP CIQ1_HUMAN 419 419
KKKKFKLDKDNGVTP Q9UMN9 419 419
KKKKFKLDKDNGVTP Q9UMN8 292 292
KKKKFKLDKDNGVTP O94787 419 419
KKKKFKLDKDNGLSP Q9Z0N7 419 419
KKKKFKLDKDNGMSP CIQ1_MOUSE 354 354
KRKKLKTDKDNGLNS O73925 410 410
KCNQ1CHANNEL2 Length of motif = 22 Motif number = 2
KCNQ1 voltage-gated potassium channel motif II - 2
PCODE ST INT
EKMLTVPHITCDPPEERRLDHF CIQ1_HUMAN 435 1
EKMLTVPHITCDPPEERRLDHF Q9UMN9 435 1
EKMLTVPHITCDPPEERRLDHF Q9UMN8 308 1
EKMLTVPHITCDPPEERRLDHF O94787 435 1
EKIFNVPHITCDPPEDRRPDHF Q9Z0N7 435 1
EKMFNVPHITYDPPEDRRPDHF CIQ1_MOUSE 370 1
EKSLNVPNITYDHVVDKDDRKF O73925 425 0
KCNQ1CHANNEL3 Length of motif = 15 Motif number = 3
KCNQ1 voltage-gated potassium channel motif III - 2
PCODE ST INT
SVDGYDSSVRKSPTL CIQ1_HUMAN 457 0
SVDGYDSSVRKSPTL Q9UMN9 457 0
SVDGYDSSVRKSPTL Q9UMN8 330 0
SVDGYDSSVRKSPTL O94787 457 0
SIDGYDSSVRKSPTL Q9Z0N7 457 0
SIDGYDSSVRKSPTL CIQ1_MOUSE 392 0
NIDGYDSSVKKSLGI O73925 450 3
KCNQ1CHANNEL4 Length of motif = 15 Motif number = 4
KCNQ1 voltage-gated potassium channel motif IV - 2
PCODE ST INT
LEVSMPHFMRTNSFA CIQ1_HUMAN 472 0
LEVSMPHFMRTNSFA Q9UMN9 472 0
LEVSMPHFMRTNSFA Q9UMN8 345 0
LEVSMPHFMRTNSFA O94787 472 0
LEVSTPHFLRTNSFA Q9Z0N7 472 0
LELSTPHFLRTNSFA CIQ1_MOUSE 407 0
LDVNSGALSRANSYA O73925 465 0
KCNQ1CHANNEL5 Length of motif = 17 Motif number = 5
KCNQ1 voltage-gated potassium channel motif V - 2
PCODE ST INT
LEGETLLTPITHISQLR CIQ1_HUMAN 491 4
LEGETLLTPITHISQLR Q9UMN9 491 4
LEGETLLTPITHISQLR Q9UMN8 364 4
LEGETLLTPITHISQLR O94787 491 4
LEGETLLTPITHVSQLR Q9Z0N7 491 4
LEGETLLTPITHVSQLR CIQ1_MOUSE 426 4
IEGEPVLAPITHVSQLR O73925 485 5
KCNQ1CHANNEL6 Length of motif = 18 Motif number = 6
KCNQ1 voltage-gated potassium channel motif VI - 2
PCODE ST INT
EHHRATIKVIRRMQYFVA CIQ1_HUMAN 508 0
EHHRATIKVIRRMQYFVA Q9UMN9 508 0
EHHRATIKVIRRMQYFVA Q9UMN8 381 0
EHHRATIKVIRRMQYFVA O94787 508 0
DHHRATIKVIRRMQYFVA Q9Z0N7 508 0
DHHRATIKVIRRMQYFVA CIQ1_MOUSE 443 0
ESHRVTVKVIRRMQYFVA O73925 502 0
KCNQ1CHANNEL7 Length of motif = 20 Motif number = 7
KCNQ1 voltage-gated potassium channel motif VII - 2
PCODE ST INT
VSEKSKDRGSNTIGARLNRV CIQ1_HUMAN 576 50
VSEKSKDRGSNTIGARLNRV Q9UMN9 576 50
VSEKSKDRGSNTIGARLNRV Q9UMN8 449 50
VSEKSKDRGSNTIGARLNRV O94787 576 50
ISEKSKDRGSNTIGARLNRV Q9Z0N7 576 50
ISEKSKDRGSNTIGARLNRV CIQ1_MOUSE 511 50
VSEKSQDRGKNTIGARLNRV O73925 570 50
KCNQ1CHANNEL8 Length of motif = 21 Motif number = 8
KCNQ1 voltage-gated potassium channel motif VIII - 2
PCODE ST INT
EDKVTQLDQRLALITDMLHQL CIQ1_HUMAN 596 0
EDKVTQLDQRLALITDMLHQL Q9UMN9 596 0
EDKVTQLDQRLALITDMLHQL Q9UMN8 469 0
EDKVTQLDQRLALITDMLHQL O94787 596 0
EDKVTQLDQRLVIITDMLHQL Q9Z0N7 596 0
EDKVTQLDQRLVIITDMLHQL CIQ1_MOUSE 531 0
EEKFVHMDQKLNTITDMLHHL O73925 590 0
KCNQ1CHANNEL9 Length of motif = 14 Motif number = 9
KCNQ1 voltage-gated potassium channel motif IX - 2
PCODE ST INT
PELFLPSNTLPTYE CIQ1_HUMAN 650 33
PELFLPSNTLPTYE Q9UMN9 650 33
PELFLPSNTLPTYE Q9UMN8 523 33
PELFLPSNTLPTYE O94787 650 33
PELFLPSNSLPTYE Q9Z0N7 643 26
PELFLPSNSLPTYE CIQ1_MOUSE 578 26
THSSLPSYEQLTVR O73925 637 26
User query: Display/Full Code "KCNQ1CHANNEL"