WORKLIST ENTRIES (1):
KCNECHANNEL View alignment KCNE voltage-gated K+ channel family E signature
Type of fingerprint: COMPOUND with 3 elements
Links:
PRINTS; PR01491 KVCHANNEL; PR01604 KCNE1CHANNEL; PR01605 KCNE2CHANNEL
PRINTS; PR01606 KCNE3CHANNEL
PFAM; PF02060 ISK_Channel
INTERPRO; IPR000369
Creation date 19-MAR-1993; UPDATE 01-DEC-2009
1. MILLER, C.
An overview of the potassium channel family.
GENOME BIOL. 1(4) 1-5 (2000).
2. CONLEY, E.C. AND BRAMMAR, W.J.
MinK.
IN THE ION CHANNEL FACTSBOOK, VOLUME IV, ACADEMIC PRESS, 1999, PP.703-767.
Potassium ion (K+) channels are a structurally diverse group of proteins
that facilitate the flow of K+ ions across cell membranes. They are
ubiquitous, being present in virtually all cell types. Activation of K+
channels tends to hyperpolarise cells, reducing the membrane's electrical
resistance, dampening nervous activity. In eukaryotic cells, K+ channels
are involved in neural signalling and generation of the cardiac rhythm, and
act as effectors in signal transduction pathways involving G protein-
coupled receptors (GPCRs). In prokaryotic cells, they play a role in the
maintenance of ionic homeostasis [1].
Some types of K+ channel are closed at the resting potential of the cell,
but open on membrane depolarisation, and are thus known as voltage-gated
channels. Each of these types of channel typically comprises 4 pore-forming
alpha subunits that may associate with one of a number of different types of
beta subunit. Two types of beta subunit (KCNE and KCNAB) are presently known
to associate with voltage-gated alpha subunits (Kv, KCNQ and eag-like).
However, not all combinations of alpha and beta subunits are possible.
The KCNE family of K+ channel subunits are membrane glycoproteins that
possess a single transmembrane (TM) domain. They share no structural
relationship with the alpha subunit proteins, which possess pore forming
domains. The subunits appear to have a regulatory function, modulating the
kinetics and voltage dependence of the alpha subunits of voltage-dependent
K+ channels [2]. KCNE subunits are formed from short polypeptides of ~130
amino acids, and are divided into five subfamilies: KCNE1 (MinK/IsK),
KCNE2 (MiRP1), KCNE3 (MiRP2), KCNE4 (MiRP3) and KCNE1L (AMMECR2).
KCNECHANNEL is a 3-element fingerprint that provides a signature for the
KCNE voltage-gated K+ channel family E. The fingerprint was derived from an
initial alignment of 9 sequences: the motifs were drawn from conserved
regions spannning the central portion of the alignment: motifs 1 and 2 span
the TM domain; and motif 3 spans the C-terminus of the TM domain and the
N-terminus of the cytoplasmic tail. Two iterations on SPTR39.22_17.3f were
required to reach convergence, at which point a true set comprising 14
sequences was identified.
An update on SPTR57_40f identified a true set of 18 sequences. Two partial
matches were also found, Q8AWZ9_XENLA and Q8AWZ8_XENLA, which are frog
translated mRNA sequences that fail to make a significant match to motif 1.
SUMMARY INFORMATION
18 codes involving 3 elements
2 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
3| 18 18 18
2| 0 2 2
--+----------------
| 1 2 3
True positives..
KCNE1_CAVPO Q545H6_MOUSE KCNE1_RAT KCNE1_PIG
KCNE1_MOUSE KCNE1_FELCA A7LFK5_RABIT KCNE1_RABIT
Q2KHV0_BOVIN B4E2L9_HUMAN KCNE1_PONAB KCNE1_HUMAN
KCNE3_HUMAN Q6IAE6_HUMAN Q545H9_MOUSE KCNE3_RAT
KCNE3_MOUSE Q8MIS1_PIG
Subfamily: Codes involving 2 elements
Subfamily True positives..
Q8AWZ9_XENLA Q8AWZ8_XENLA
PROTEIN TITLES
KCNE1_CAVPO Potassium voltage-gated channel subfamily E member 1 - Cavia
Q545H6_MOUSE Potassium voltage-gated channel subfamily E member - Mus mus
KCNE1_RAT Potassium voltage-gated channel subfamily E member 1 - Rattu
KCNE1_PIG Potassium voltage-gated channel subfamily E member 1 - Sus s
KCNE1_MOUSE Potassium voltage-gated channel subfamily E member 1 - Mus m
KCNE1_FELCA Potassium voltage-gated channel subfamily E member 1 - Felis
A7LFK5_RABIT Potassium voltage-gated channel subfamily E member - Oryctol
KCNE1_RABIT Potassium voltage-gated channel subfamily E member 1 - Oryct
Q2KHV0_BOVIN Potassium voltage-gated channel subfamily E member - Bos tau
B4E2L9_HUMAN cDNA FLJ61204, highly similar to Potassium voltage-gated cha
KCNE1_PONAB Potassium voltage-gated channel subfamily E member 1 - Pongo
KCNE1_HUMAN Potassium voltage-gated channel subfamily E member 1 - Homo
KCNE3_HUMAN Potassium voltage-gated channel subfamily E member 3 - Homo
Q6IAE6_HUMAN Potassium voltage-gated channel subfamily E member - Homo sa
Q545H9_MOUSE Potassium voltage-gated channel subfamily E member - Mus mus
KCNE3_RAT Potassium voltage-gated channel subfamily E member 3 - Rattu
KCNE3_MOUSE Potassium voltage-gated channel subfamily E member 3 - Mus m
Q8MIS1_PIG Potassium voltage-gated channel subfamily E member - Sus scr
Q8AWZ9_XENLA Potassium voltage-gated channel subfamily E member - Xenopus
Q8AWZ8_XENLA Voltage-gated potassium channel subunit MiRP2 (KCNE3 protein
SCAN HISTORY
SPTR39.22_17.3f 2 210 NSINGLE
SPTR57_40f 3 250 NSINGLE
INITIAL MOTIF SETS
KCNECHANNEL1 Length of motif = 9 Motif number = 1
KCNE voltage-gated K+ channel family E motif I - 1
PCODE ST INT
EALYILMVL MINK_CAVPO 43 43
EALYILMVL MINK_FELCA 43 43
EALYVLMVL MINK_HUMAN 43 43
VILYLMVMI MIR1_HUMAN 49 49
VILYLMVMI MIR1_RAT 49 49
SYMYILFVM MIR2_HUMAN 57 57
SYMYILFVM MIR2_MOUSE 57 57
SYMYILFVM MIR2_RAT 61 61
EYFYILVVM MIR3_MOUSE 35 35
KCNECHANNEL2 Length of motif = 12 Motif number = 2
KCNE voltage-gated K+ channel family E motif II - 1
PCODE ST INT
GFFGFFTLGIML MINK_CAVPO 52 0
GFFGFFTLGIML MINK_FELCA 52 0
GFFGFFTLGIML MINK_HUMAN 52 0
GMFSFIIVAILV MIR1_HUMAN 58 0
GMFAFIVVAILV MIR1_RAT 58 0
FLFAVTVGSLIL MIR2_HUMAN 66 0
FLFAVTVGSLIL MIR2_MOUSE 66 0
FLFAVTVGSLIL MIR2_RAT 70 0
SFYGVFLIGIML MIR3_MOUSE 44 0
KCNECHANNEL3 Length of motif = 9 Motif number = 3
KCNE voltage-gated K+ channel family E motif III - 1
PCODE ST INT
SYIRSKKLE MINK_CAVPO 64 0
SYIRSKKLE MINK_FELCA 64 0
SYIRSKKLE MINK_HUMAN 64 0
STVKSKRRE MIR1_HUMAN 70 0
STVKSKRRE MIR1_RAT 70 0
GYTRSRKVD MIR2_HUMAN 78 0
GYTRSRKVD MIR2_MOUSE 78 0
GYTRSRKVD MIR2_RAT 82 0
GYMKSKRRE MIR3_MOUSE 56 0
FINAL MOTIF SETS
KCNECHANNEL1 Length of motif = 9 Motif number = 1
KCNE voltage-gated K+ channel family E motif I - 3
PCODE ST INT
EALYILMVL KCNE1_CAVPO 43 43
EALYILMVL Q545H6_MOUSE 43 43
EALYILMVL KCNE1_RAT 44 44
EALYILMVL KCNE1_PIG 44 44
EALYILMVL KCNE1_MOUSE 43 43
EALYILMVL KCNE1_FELCA 43 43
EALYILMVL A7LFK5_RABIT 44 44
EALYILMVL KCNE1_RABIT 44 44
AALYILMVL Q2KHV0_BOVIN 43 43
EALYVLMVL B4E2L9_HUMAN 17 17
EALYVLMVL KCNE1_PONAB 43 43
EALYVLMVL KCNE1_HUMAN 43 43
SYMYILFVM KCNE3_HUMAN 57 57
SYMYILFVM Q6IAE6_HUMAN 57 57
SYMYILFVM Q545H9_MOUSE 57 57
SYMYILFVM KCNE3_RAT 61 61
SYMYILFVM KCNE3_MOUSE 57 57
SYMYILFVM Q8MIS1_PIG 53 53
KCNECHANNEL2 Length of motif = 12 Motif number = 2
KCNE voltage-gated K+ channel family E motif II - 3
PCODE ST INT
GFFGFFTLGIML KCNE1_CAVPO 52 0
GFFGFFTLGIML Q545H6_MOUSE 52 0
GFFGFFTLGIML KCNE1_RAT 53 0
GFFGFFTLGIML KCNE1_PIG 53 0
GFFGFFTLGIML KCNE1_MOUSE 52 0
GFFGFFTLGIML KCNE1_FELCA 52 0
GFFGFFTLGIML A7LFK5_RABIT 53 0
GFFGFFTLGIML KCNE1_RABIT 53 0
GFFGFFTLGIML Q2KHV0_BOVIN 52 0
GFFGFFTLGIML B4E2L9_HUMAN 26 0
GFFGFFTLGIML KCNE1_PONAB 52 0
GFFGFFTLGIML KCNE1_HUMAN 52 0
FLFAVTVGSLIL KCNE3_HUMAN 66 0
FLFAVTVGSLIL Q6IAE6_HUMAN 66 0
FLFAVTVGSLIL Q545H9_MOUSE 66 0
FLFAVTVGSLIL KCNE3_RAT 70 0
FLFAVTVGSLIL KCNE3_MOUSE 66 0
FLFAATVGSLIL Q8MIS1_PIG 62 0
KCNECHANNEL3 Length of motif = 9 Motif number = 3
KCNE voltage-gated K+ channel family E motif III - 3
PCODE ST INT
SYIRSKKLE KCNE1_CAVPO 64 0
SYIRSKKLE Q545H6_MOUSE 64 0
SYIRSKKLE KCNE1_RAT 65 0
SYIRSKKLE KCNE1_PIG 65 0
SYIRSKKLE KCNE1_MOUSE 64 0
SYIRSKKLE KCNE1_FELCA 64 0
SYIRSQKLE A7LFK5_RABIT 65 0
SYIRSQKLE KCNE1_RABIT 65 0
SYIRSKKLE Q2KHV0_BOVIN 64 0
SYIRSKKLE B4E2L9_HUMAN 38 0
SYIRSKKLE KCNE1_PONAB 64 0
SYIRSKKLE KCNE1_HUMAN 64 0
GYTRSRKVD KCNE3_HUMAN 78 0
GYTRSRKVD Q6IAE6_HUMAN 78 0
GYTRSRKVD Q545H9_MOUSE 78 0
GYTRSRKVD KCNE3_RAT 82 0
GYTRSRKVD KCNE3_MOUSE 78 0
GYTRSRKVD Q8MIS1_PIG 74 0
User query: Display/Full Code "KCNECHANNEL"